The role of phosphorylation in neurofilament function and dysfunction.
Lead Research Organisation:
King's College London
Department Name: Unlisted
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Tudor EL
(2005)
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
in The Journal of biological chemistry
Miller C
(2014)
Axonal transport of neurofilaments in normal and disease states
in Cellular and Molecular Life Sciences CMLS
Angeletti B
(2005)
BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.
in The Journal of biological chemistry
Brownlees J
(2002)
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport.
in Human molecular genetics
Lau KF
(2002)
Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.
in Molecular and cellular neurosciences
Manser C
(2008)
Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport.
in FEBS letters
Lau KF
(2008)
Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.
in The Journal of biological chemistry
Kasher PR
(2009)
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
in Journal of neurochemistry
Turner MR
(2004)
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.
in Neurobiology of disease
De Vos KJ
(2007)
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
in Human molecular genetics
| Description | Axonal transport, protein trafficking and Alzheimerâ??s disease |
| Amount | £74,142 (GBP) |
| Funding ID | ART-PhD2006-2 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2006 |
| End | 10/2009 |
| Description | CS -Wellcome Trust/MRC neurodegenerative diseases strategic award |
| Amount | £7,372,440 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2010 |
| End | 01/2015 |
| Description | MRC Programme Grant |
| Amount | £1,246,890 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2006 |
| End | 08/2014 |
| Description | Protein kinase-N (PKN) signalling and neurodegeneration in ALS. |
| Amount | £63,021 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2004 |
| End | 09/2007 |
| Description | cdk5 signalling and disruption to the Golgi apparatus in amyotrophic lateral sclerosis |
| Amount | £73,868 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2005 |
| End | 09/2009 |