The role of phosphorylation in neurofilament function and dysfunction.
Lead Research Organisation:
King's College London
Department Name: Unlisted
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications

Ackerley S
(2003)
Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.
in The Journal of cell biology

Ackerley S
(2004)
p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.
in Molecular and cellular neurosciences

Al-Chalabi A
(2003)
Neurofilaments and neurological disease.
in BioEssays : news and reviews in molecular, cellular and developmental biology

Angeletti B
(2005)
BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.
in The Journal of biological chemistry

Brownlees J
(2002)
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport.
in Human molecular genetics

Chibalina MV
(2007)
Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.
in Journal of cell science

Cullen VC
(2004)
Gigaxonin is associated with the Golgi and dimerises via its BTB domain.
in Neuroreport

De Vos KJ
(2008)
Role of axonal transport in neurodegenerative diseases.
in Annual review of neuroscience

De Vos KJ
(2007)
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
in Human molecular genetics

Kasher PR
(2009)
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
in Journal of neurochemistry

Kesavapany S
(2003)
Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.
in The Journal of neuroscience : the official journal of the Society for Neuroscience

Lau KF
(2008)
Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.
in The Journal of biological chemistry

Lau KF
(2002)
Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.
in Molecular and cellular neurosciences

Lee CW
(2003)
Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines.
in Neuroreport

Lee JH
(2003)
The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.
in The Journal of biological chemistry

Lee JH
(2004)
The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice.
in The Journal of biological chemistry

Manser C
(2008)
Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport.
in FEBS letters

McLoughlin DM
(2008)
The FE65 proteins and Alzheimer's disease.
in Journal of neuroscience research

Miller C
(2014)
Axonal transport of neurofilaments in normal and disease states
in Cellular and Molecular Life Sciences CMLS

Miller CC
(2006)
The X11 proteins, Abeta production and Alzheimer's disease.
in Trends in neurosciences

Mitchell JC
(2009)
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
in Human molecular genetics

Panzeri C
(2006)
The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function.
in Brain : a journal of neurology

Perkinton MS
(2004)
The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
in The Journal of biological chemistry

Rogelj B
(2006)
The X11/Mint family of adaptor proteins.
in Brain research reviews

Saha AR
(2004)
Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons.
in Journal of cell science

Sreedharan J
(2008)
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis.
in Science (New York, N.Y.)

Standen CL
(2003)
The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).
in Molecular and cellular neurosciences

Stevenson A
(2009)
Riluzole protects against glutamate-induced slowing of neurofilament axonal transport.
in Neuroscience letters

Tudor EL
(2005)
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
in The Journal of biological chemistry

Turner MR
(2004)
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.
in Neurobiology of disease

Utton MA
(2002)
The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons.
in The Journal of neuroscience : the official journal of the Society for Neuroscience

Yates DM
(2009)
Neurofilament subunit (NFL) head domain phosphorylation regulates axonal transport of neurofilaments.
in European journal of cell biology
Description | Axonal transport, protein trafficking and Alzheimerâ??s disease |
Amount | £74,142 (GBP) |
Funding ID | ART-PhD2006-2 |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2006 |
End | 10/2009 |
Description | CS -Wellcome Trust/MRC neurodegenerative diseases strategic award |
Amount | £7,372,440 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2010 |
End | 01/2015 |
Description | MRC Programme Grant |
Amount | £1,246,890 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2006 |
End | 08/2014 |
Description | Protein kinase-N (PKN) signalling and neurodegeneration in ALS. |
Amount | £63,021 (GBP) |
Organisation | Motor Neurone Disease Association (MND) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2004 |
End | 09/2007 |
Description | cdk5 signalling and disruption to the Golgi apparatus in amyotrophic lateral sclerosis |
Amount | £73,868 (GBP) |
Organisation | Motor Neurone Disease Association (MND) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2005 |
End | 09/2009 |