The role of phosphorylation in neurofilament function and dysfunction.
Lead Research Organisation:
King's College London
Department Name: Unlisted
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Ackerley S
(2003)
Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.
in The Journal of cell biology
Ackerley S
(2004)
p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.
in Molecular and cellular neurosciences
Al-Chalabi A
(2003)
Neurofilaments and neurological disease.
in BioEssays : news and reviews in molecular, cellular and developmental biology
Angeletti B
(2005)
BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.
in The Journal of biological chemistry
Brownlees J
(2002)
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport.
in Human molecular genetics
Chibalina MV
(2007)
Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.
in Journal of cell science
Cullen VC
(2004)
Gigaxonin is associated with the Golgi and dimerises via its BTB domain.
in Neuroreport
De Vos KJ
(2008)
Role of axonal transport in neurodegenerative diseases.
in Annual review of neuroscience
De Vos KJ
(2007)
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
in Human molecular genetics
Kasher PR
(2009)
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
in Journal of neurochemistry
Kesavapany S
(2003)
Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Lau KF
(2008)
Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.
in The Journal of biological chemistry
Lau KF
(2002)
Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.
in Molecular and cellular neurosciences
Lee CW
(2003)
Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines.
in Neuroreport
Lee JH
(2003)
The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.
in The Journal of biological chemistry
Lee JH
(2004)
The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice.
in The Journal of biological chemistry
Manser C
(2008)
Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport.
in FEBS letters
McLoughlin DM
(2008)
The FE65 proteins and Alzheimer's disease.
in Journal of neuroscience research
Miller C
(2014)
Axonal transport of neurofilaments in normal and disease states
in Cellular and Molecular Life Sciences CMLS
Miller CC
(2006)
The X11 proteins, Abeta production and Alzheimer's disease.
in Trends in neurosciences
Mitchell JC
(2009)
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
in Human molecular genetics
Panzeri C
(2006)
The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function.
in Brain : a journal of neurology
Perkinton MS
(2004)
The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
in The Journal of biological chemistry
Rogelj B
(2006)
The X11/Mint family of adaptor proteins.
in Brain research reviews
Saha AR
(2004)
Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons.
in Journal of cell science
Sreedharan J
(2008)
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis.
in Science (New York, N.Y.)
Standen CL
(2003)
The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).
in Molecular and cellular neurosciences
Stevenson A
(2009)
Riluzole protects against glutamate-induced slowing of neurofilament axonal transport.
in Neuroscience letters
Tudor EL
(2005)
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
in The Journal of biological chemistry
Turner MR
(2004)
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.
in Neurobiology of disease
Utton MA
(2002)
The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Yates DM
(2009)
Neurofilament subunit (NFL) head domain phosphorylation regulates axonal transport of neurofilaments.
in European journal of cell biology
| Description | Axonal transport, protein trafficking and Alzheimerâ??s disease |
| Amount | £74,142 (GBP) |
| Funding ID | ART-PhD2006-2 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2006 |
| End | 10/2009 |
| Description | CS -Wellcome Trust/MRC neurodegenerative diseases strategic award |
| Amount | £7,372,440 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2010 |
| End | 01/2015 |
| Description | MRC Programme Grant |
| Amount | £1,246,890 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2006 |
| End | 08/2014 |
| Description | Protein kinase-N (PKN) signalling and neurodegeneration in ALS. |
| Amount | £63,021 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2004 |
| End | 09/2007 |
| Description | cdk5 signalling and disruption to the Golgi apparatus in amyotrophic lateral sclerosis |
| Amount | £73,868 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2005 |
| End | 09/2009 |