Structural Biology of Fluid-Phase Regulators of Complement Activation & Mechanisms for Evasion of Complement by Pathogen

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Chemistry

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Barlow PN (2008) Complement factor H: using atomic resolution structure to illuminate disease mechanisms. in Advances in experimental medicine and biology

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Dhillon B (2010) Complement factor h autoantibodies and age-related macular degeneration. in Investigative ophthalmology & visual science

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Ferreira VP (2006) Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces. in Journal of immunology (Baltimore, Md. : 1950)

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Herbert AP (2006) Disease-associated sequence variations in factor H: a structural biology approach. in Advances in experimental medicine and biology

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Kuttner-Kondo L (2007) Structure-based mapping of DAF active site residues that accelerate the decay of C3 convertases. in The Journal of biological chemistry

 
Description treatment of aHUS
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact We played a tiny part in policies emanating from Newcastle University (Tim Goodship) on kidney transplants in aHUS/DDD and contributed to paper PMID 17675665
URL http://europepmc.org/abstract/MED/17675665
 
Description CSO funding (Formulation of anticomplement therapy)
Amount £75,000 (GBP)
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 12/2010 
End 11/2011
 
Description Pathfinder - for market analysis
Amount £10,000 (GBP)
Funding ID BB/FOF/PF/2/13 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2013 
End 10/2013
 
Description Sparking Impact
Amount £15,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2013 
End 12/2013
 
Description Structure-function of factor H
Amount £550,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2007 
End 12/2012
 
Title Factor H fragment library 
Description A library of factor h fragments 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2008 
Provided To Others? Yes  
Impact We receive numerous requests for our fragments from around the world - resulted in collaborations and joint publications 
 
Title structures of factor H fragments 
Description structural coordinates 
Type Of Material Database/Collection of Data/Biological Samples 
Provided To Others? No  
Impact Frequently cited and used for modelling etc. 
 
Description Collaboration on staphylococcal complement inhibitor 
Organisation University of Pennsylvania
Country United States 
Sector Academic/University 
PI Contribution Supplied reagents
Collaborator Contribution Better understanding of complement
Impact Paper PMID 19625656
Start Year 2008
 
Description Collaboration with Lund Immunochemistry 
Organisation Lund University
Country Sweden 
Sector Academic/University 
PI Contribution Contribution of molecular models and reagents
Collaborator Contribution Better understanding of factor H biology
Impact Papers PMID 19951950 and 18715646
Start Year 2006
 
Description Parnership with Tim Goodship 
Organisation Newcastle University
Department School of Clinical and Laboratory sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Supplied reagents
Collaborator Contribution Insights into role of factor H in disease
Impact Paper PMID 19861685 and PMID 20592223 and PMID 22721707
Start Year 2008
 
Description Partnership for new anticomplement therapies 
Organisation University of Edinburgh
Department MRC Centre for Inflammation Research
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of intellectual material and development of new methodologies
Collaborator Contribution Better understanding of potential for anticomplement therapies. Avenues for testing therapeutics in mouse models
Impact Patent filing and paper 21146613 Research grant funding from Chief Scientist's Office (Scotland) Joint studentship funding (Heather Kerr)
Start Year 2009
 
Description Partnership for new anticomplement therapies 
Organisation University of Edinburgh
Department Queen's Medical Research Institute Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of intellectual material and development of new methodologies
Collaborator Contribution Better understanding of potential for anticomplement therapies. Avenues for testing therapeutics in mouse models
Impact Patent filing and paper 21146613 Research grant funding from Chief Scientist's Office (Scotland) Joint studentship funding (Heather Kerr)
Start Year 2009
 
Title anticomplement 
Description Recombinant factor H - details under previous section (on IPR) 
Type Therapeutic Intervention - Drug
Current Stage Of Development Initial development
Year Development Stage Completed 2009
Development Status Actively seeking support
Impact Please see previous sections (on IPR) 
 
Description CCP module page 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Health professionals
Results and Impact web-based resource on CCP modules

site visited several dozen times per month
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010,2011,2012
 
Description Dense Deposit Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Health professionals
Results and Impact Two-day discussion on therapies for DDD

New clinical trial under orphan drug status to be established
Year(s) Of Engagement Activity 2008,2010
 
Description Press release AMD 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Articles in Daily Telegraph and BBC online plus local newspapers

Received letters from AMD sufferers asking to participate in clinical trials etc.
Year(s) Of Engagement Activity 2007