Wolfson Brain Imaging Centre (WBIC) COGG
Lead Research Organisation:
University of Cambridge
Department Name: Wolfson Brain Imaging Centre
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- University of Cambridge, United Kingdom (Lead Research Organisation)
- University of Oxford, United Kingdom (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- Chemnitz Academic Teaching Hospital (Collaboration)
- University of Bath, Bath (Collaboration)
- Kiel University, Germany (Collaboration)
- Newcastle University, United Kingdom (Collaboration)
- Cornell University (Collaboration)
- Medical Research Council (Collaboration)
- Memphis University (Collaboration)
- Intensive Care Society (Collaboration)
- University of Groningen (Collaboration)
- Royal College of Physicians of London (Collaboration)
- The Royal College of Anaesthetists (Collaboration)
- Albert Ludwig University of Freiburg (Collaboration)
- Queen's Medical Centre (Collaboration)
- University of Cambridge (Collaboration)
- University of Lisbon (Collaboration)
- University of Liege, Belgium (Collaboration)
- Siemens Healthcare (Collaboration)
- Charité - University of Medicine Berlin (Collaboration)
- University of Melbourne, Australia (Collaboration)
- University of Otago, New Zealand (Collaboration)
Publications
Abate MG
(2008)
Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity.
in Neurocritical care
Absalom AR
(2009)
BIS and spectral entropy monitoring during sedation with midazolam/remifentanil and dexmedetomidine/remifentanil.
in Critical care (London, England)
Achard S
(2007)
Efficiency and cost of economical brain functional networks.
in PLoS computational biology
Achard S
(2006)
A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Acosta-Cabronero J
(2010)
Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease.
in Brain : a journal of neurology
Acosta-Cabronero J
(2008)
The impact of skull-stripping and radio-frequency bias correction on grey-matter segmentation for voxel-based morphometry.
in NeuroImage
Allin D
(2008)
Laboratory testing of the Pressio intracranial pressure monitor.
in Neurosurgery
Allin DM
(2006)
In vitro hydrodynamic properties of the Miethke ProGAV hydrocephalus shunt.
in Cerebrospinal fluid research
Allin DM
(2008)
Investigation of the hydrodynamic properties of a new MRI-resistant programmable hydrocephalus shunt.
in Cerebrospinal fluid research
| Description | Brain Death Guidelines |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | JDP - Brain Death Guidelines Working Party (Royal College of Anaesthetists); liason with Official Solicitor over implications of advances in functional brain imaging for the management of patients in the vegetative state. |
| Description | Home Office Animal Procedures Commitee and Primate Subcommittee |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | JDP - Home Office Animal Procedures Committee and Primate Subcommittee [Chairman]. Chairman of 'Pickard Report on Cumulative Severity and lifetime experience in non-human primates used in neuroscience research' published November 2013. |
| Description | Management of incidentalomas identified in research brain scans of volunteers. |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| Impact | This ethical problem has now become a major issue - see recent Wellcome/SINAPSE ,meeting 2010 and Wardlaw report in BMJ 2015 referenced above |
| Description | Mental Health Capacity |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Impact | • DKM - Intensive care society: development of new legislation and regulations concerning Mental Capacity, Human Tissue Act, Clinical Trials Directive, data Protection Act. |
| Description | A new collaborative ultra-high field MRI facility for dementia and neuroscience research - 7T MRI MRC Award: MR/M008983/1 PI: Prof J Rowe Total Award: £6,950,000 |
| Amount | £6,950,000 (GBP) |
| Funding ID | MR/M008983/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2015 |
| End | 03/2016 |
| Description | British Journal of Anaesthesia/Royal College of Anaesthetists project grant: Imaging |
| Amount | £52,856 (GBP) |
| Organisation | The Royal College of Anaesthetists |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Cambridge PET Neurochemist Programme |
| Amount | £745,000 (GBP) |
| Funding ID | G0900903 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Cerebral Energy Metabolism in Injured and Uninjured Brain |
| Amount | £504,688 (GBP) |
| Funding ID | G1002277 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Department of Health Technology Platform |
| Amount | £1,896,880 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | EU Fellowship for Dr Jeroen Hermanides € |
| Amount | € 97,727 (EUR) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | EU Multicentre Project grant |
| Amount | £300,000 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Engineering and Physical Science High Resolution Simultaneous PET-MR Scanner. Awarded |
| Amount | £1,082,585 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Evelyn Trust - Role of inflammation and neovasculatirsation in expansion of small AAA. |
| Amount | £72,000 (GBP) |
| Organisation | The Evelyn Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | IMAGEN Reinforcement-related behaviour in normal brain function and psychopathology |
| Amount | £600,000 (GBP) |
| Funding ID | 37286 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Imaging Theme co-applicant |
| Amount | £6,700,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Cambridge Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Imaging inflammation in atherosclerosis: An integrated multimodality approach |
| Amount | £1,139,380 (GBP) |
| Funding ID | RG/10/007/28300 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Imaging inflammation in atherosclerosis: an integrated multimodality approach |
| Amount | £591,252 (GBP) |
| Funding ID | RG/10/007/28300 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Imaging mechanisms of energy failure following head injury. |
| Amount | £220,000 (GBP) |
| Funding ID | 093267 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Imaging the surviving penumbra and recovery after stroke |
| Amount | £843,000 (GBP) |
| Funding ID | G0500874 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MICA: Detecting ictogenicity and epileptogenesis |
| Amount | £1,635,366 (GBP) |
| Funding ID | MR/L013215/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 03/2019 |
| Description | MICA: Training and Novel Probes Programme in PET Neurochemistry - PET Call |
| Amount | £1,016,892 (GBP) |
| Funding ID | MR/K02308X/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2013 |
| End | 11/2017 |
| Description | MRC - Decompressive Craniectomy Study |
| Amount | £1,006,309 (GBP) |
| Funding ID | G0601025 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MRC Acute Brain Imaging Collaborative Grant |
| Amount | £1,357,662 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MRC Cambridge Centre for Behavioural and Clinical Neuroscience |
| Amount | £1,815,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MRC programme Grant |
| Amount | £775,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Multi-level patient-specific artery and athero-genesis model for outcome prediction, decision support treatment, and virtual hands-on training. |
| Amount | £425,753 (GBP) |
| Funding ID | 224297 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | NIHR Biomedical research Centre |
| Amount | £1,600,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Cambridge Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | NIHR HTC for Brain Injury |
| Amount | £800,000 (GBP) |
| Organisation | Barts Health NHS Trust |
| Department | NIHR Biomedical Research Unit |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 12/2017 |
| Description | Neurobiological correlates of trait impulsifvity an ddrug abuse vulnerability |
| Amount | £1,134,962 (GBP) |
| Funding ID | G0701500 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | New drugs for addiction: focus on attenuating core behavioural component of heroin, cocaine and alcohol addiction and relapse prevention. |
| Amount | £1,774,000 (GBP) |
| Funding ID | G1000018 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Novel Mitochondria-targeted PET probe |
| Amount | £82,500 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | The British Oxygen Professorship: Imaging anaesthetic action in the brain. |
| Amount | £320,943 (GBP) |
| Organisation | The Royal College of Anaesthetists |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | The Evelyn Trust. Cognitive disfunction after head injury:Neuroanatomical correlates and drug therapy/Evelyn Trust |
| Amount | £120,400 (GBP) |
| Organisation | The Evelyn Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | The HIF system in traumatic brain injury. |
| Amount | £188,599 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Theme 1: Innovative Technologies for Stratified and Experimental Medicine MRC Award: MR/M009041/1 PI: Regius Professor P Maxwell Molecular Imaging Centre - £7,821,704 Sub-total: HPHI Informatics (WBIC) - £795,974 |
| Amount | £14,621,436 (GBP) |
| Funding ID | MR/M009041/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2015 |
| End | 03/2016 |
| Description | Towards a biomechanics-based vulnerability assessment tool for carotid atherosclerotic plaque: mechanical property testing and MRI-based computaional modelling |
| Amount | £193,818 (GBP) |
| Funding ID | PG/11/74/29100 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Vegetative State |
| Amount | $500,000 (USD) |
| Organisation | James S. McDonnell Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 08/2013 |
| End | 07/2017 |
| Title | MICL |
| Description | Establishment of the Molecular Imaging Chemistry Laboratory at Forvie Site, Cambridge Biomedical Campus, Cambridge (2008): a dedicated facility for the development, synthesis and evaluation of novel imaging probes. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | Major new grants to support dementia initiative |
| Title | Microfluidic methods for PET radiopharmaceuticals |
| Description | Development of microfluidic methods for the preparation of PET radiopharmaceuticals |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | TBD |
| Title | Novel 11C-METHIONINE PET for pituitary micro adenomas |
| Description | Functioning pituitary micro adenomas can be very difficult to identify on conventional MR scanning. Dr Mark Gurnell, Dr Franklin AIgbirhio and Professor Pickard in collaboration with colleagues have developed a PET imaging technique based on 11C-Methionine based on an initial contribution of £10000 from JDP's Senior Investigator Award.The Cambridge Pituitary MDT Clinic now attracts tertiary referrals from throughout the UK and abroad for this technique. Oral/pleanry presentations have been given in San Francisco, Sydney and Munich. 3 major papers are in preparation. |
| Type Of Material | Model of mechanisms or symptoms - human |
| Provided To Others? | No |
| Impact | A very difficult group of patients with refractory functioning pituitary micoadenomas are now being offered highly selective endoscopic re-do pituitary operations thereby improving outcomes and reducing the need for expensive and ineffective drug therapies. |
| Title | functional MR and EEG paradigms for assessment of covert awareness |
| Description | Study of patients in low awareness states requires the development of psychological paradigms that can be applied in brain scanners including PET and MR. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Major papers in Science, NEJM and worldwide publicity |
| Description | Altered States of Consciousness - International Collaborations |
| Organisation | Cornell University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Pickard JD: Collaobrations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor. |
| Impact | See publications lists and new grants. |
| Description | Altered States of Consciousness - International Collaborations |
| Organisation | Royal College of Physicians of London |
| Country | United Kingdom |
| Sector | Learned Society |
| PI Contribution | Pickard JD: Collaobrations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor. |
| Impact | See publications lists and new grants. |
| Description | Altered States of Consciousness - International Collaborations |
| Organisation | The Royal College of Anaesthetists |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Pickard JD: Collaobrations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor. |
| Impact | See publications lists and new grants. |
| Description | Altered States of Consciousness - International Collaborations |
| Organisation | University of Liege |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | Pickard JD: Collaobrations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor. |
| Impact | See publications lists and new grants. |
| Description | Altered States of Consciousness - International Collaborations |
| Organisation | University of Melbourne |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Pickard JD: Collaborations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor |
| Impact | See publications lists and new grants. |
| Description | Application of PET in addiction research |
| Organisation | University of Cambridge |
| Department | Department of Psychology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Application of PET in addiction research. |
| Impact | n/a |
| Start Year | 2010 |
| Description | Council of Intensive Care Society |
| Organisation | Intensive Care Society |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | D.K Menon: Council of the Intensive Care Society - special respnsibility for the development of new legislation and regulations concerning Menal Capacity, Human Tissue Act, Clinical trials Directive and Data Protection Act. 2003 - 2009 |
| Impact | Submission of input into grant from Department of Constitutional Affairs which led to a booklet being provided on the Society for Intensive Care Website. |
| Description | Development of novel fluorination method |
| Organisation | Newcastle University |
| Department | School of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of novel fluorination method using iodonium compounds |
| Impact | tba |
| Start Year | 2009 |
| Description | ERASMUS Exchange Programme |
| Organisation | University of Groningen |
| Department | Department of Biomedical Engineering |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We provided human resources and research infrastructure for MSc students |
| Collaborator Contribution | MSc students |
| Impact | Publications |
| Start Year | 2011 |
| Description | ERASMUS Exchange Programme |
| Organisation | University of Lisbon |
| Department | Institute of Biophysics and Biomedical Engineering |
| Country | Portugal |
| Sector | Academic/University |
| PI Contribution | We provided human resources and research infrastructure for MSc students |
| Collaborator Contribution | MSc students |
| Impact | Publications |
| Start Year | 2011 |
| Description | ICNARC and NCCnet |
| Organisation | Queen's Medical Centre |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | ICNARC and NCCnet: Professor of Anaesthesia serves on the Management Board of the UK Intensive Care National Audit and Research Centre (ICNARC), and is Project Lead for NCCNet (http://www.nccnet.org.uk) - a research collaborative of UK neurocritical care units. |
| Impact | A collaboration that included ICNARC and NCCNet was recently awarded a £595,000 grant from the HTA. |
| Start Year | 2011 |
| Description | International Fellows |
| Organisation | University of Melbourne |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Steiner (Basal), Abate (Milan), Owler (Sydney), Zegan (Calgary), Gallagher (Calgary), Lewis (Melbourne) University of Melbeurne (Phil Lewis), Eric Schmidt (Toulouse), Jager (Leipzig), Momjian (Geneva), Lavinio (Brescia), Petrella (Rome), Balestreri (Pavia), Soehle (Bonn). |
| Impact | See publication listing |
| Start Year | 2006 |
| Description | MR Elastography |
| Organisation | Charité - University of Medicine Berlin |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We implemented and tested MRE equipment and methods on a 3T system. Developed an add-on for the image acquisition that allows automatic in-line analysis. |
| Collaborator Contribution | Delivered the concept for equipment and method and offered expertise in the clinical use of the methods |
| Impact | Constant improve of image acquisition and analysis methods. |
| Start Year | 2009 |
| Description | MR Elastography |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We implemented and tested MRE equipment and methods on a 3T system. Developed an add-on for the image acquisition that allows automatic in-line analysis. |
| Collaborator Contribution | Delivered the concept for equipment and method and offered expertise in the clinical use of the methods |
| Impact | Constant improve of image acquisition and analysis methods. |
| Start Year | 2009 |
| Description | Mitochondrial PET Probes |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Mitochondrial Biology Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Radiosynthesis and biological evaluation of the PET radioligands |
| Collaborator Contribution | Novel PET probes. Synthesis and biological evaluation of novel chemical entities. |
| Impact | PMID: 20621583 |
| Start Year | 2008 |
| Description | Non-invasive assessment of intracranial pressure |
| Organisation | Albert Ludwig University of Freiburg |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang). |
| Impact | See publications listing |
| Start Year | 2006 |
| Description | Non-invasive assessment of intracranial pressure |
| Organisation | Chemnitz Academic Teaching Hospital |
| Department | Department of Neurology |
| Country | Germany |
| Sector | Hospitals |
| PI Contribution | Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang). |
| Impact | See publications listing |
| Start Year | 2006 |
| Description | Non-invasive assessment of intracranial pressure |
| Organisation | University of Kiel |
| Department | Department of Neurosurgery |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang). |
| Impact | See publications listing |
| Start Year | 2006 |
| Description | Non-invasive assessment of intracranial pressure |
| Organisation | University of Memphis |
| Department | Medical Engineering Memphis |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang). |
| Impact | See publications listing |
| Start Year | 2006 |
| Description | Novel Copper-64 |
| Organisation | University of Bath |
| Department | Department of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Novel Copper-65 molecular imaging probes |
| Impact | tba |
| Start Year | 2008 |
| Description | Novel PET probes |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Clinical Sciences Centre (CSC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Development of novel PET probes of mitochondirial dysfunction |
| Impact | tba |
| Start Year | 2009 |
| Description | Novel PET probes |
| Organisation | University of Otago |
| Country | New Zealand |
| Sector | Academic/University |
| PI Contribution | Development of novel PET probes of mitochondirial dysfunction |
| Impact | tba |
| Start Year | 2009 |
| Description | Novel copper-64 |
| Organisation | University of Oxford |
| Department | Department of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of Copper-64 hypoxia markers |
| Impact | tba |
| Start Year | 2007 |
| Description | PET in stroke research |
| Organisation | University of Cambridge |
| Department | School of Clinical Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Application of PET in Stroke Research with Prof Jean-Claude Baron of Neurology/Stroke |
| Impact | see publications listing |
| Description | Siemens MRI |
| Organisation | Siemens Healthcare |
| Department | Siemens Medical Solutions |
| Country | Germany |
| Sector | Private |
| PI Contribution | Development of pulse sequences for use on Siemens MRI systems |
| Collaborator Contribution | Provision of the software development environment. Access to collaboration manager. |
| Impact | Improved pulse sequences for diffusion modelling and real-time fMRI |
| Start Year | 2006 |
| Description | Siemens Molecular Imaging |
| Organisation | Siemens Healthcare |
| Department | Siemens Medical Solutions |
| Country | Germany |
| Sector | Private |
| PI Contribution | Research collaboration in the development of PET probes for neurodegeneration. |
| Impact | tba |
| Start Year | 2009 |
| Title | ICM+ software |
| Description | Software that allows the collection of data from multimodlaity bedside monitors in neurointensive care and subsequent analysis in real time. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | |
| Licensed | Yes |
| Impact | ICM+ is the basis of a multinational collaboration of worldclass neurointensive care units. |
| Title | 18F labelled endothelin and urotensin-II |
| Description | Automated synthesis of the generic peptide labelling agent N-succinimidyl 4-[(18)F]fluorobenzoate for synthesis of 18F labelled peptides for clinical use and application to (18)F-label to vasoactive transmitters endothelin and urotensin-II as ligands for positron emission tomography. |
| Type | Diagnostic Tool - Imaging |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2007 |
| Development Status | On hold |
| Impact | Publication of method has been adopted by others for synthesis of peptides for clinical use. |
| Title | ICMplus |
| Description | ICM+ software [www.neurosurg.cam.ac.uk/icmplus]. ICM+ captures the enormous quantities of physiological data from each patient in an neurointensive care environment form which information about cerebral auto regulation, cerebral compensatory reserve, oxygenation, metabolite production and function can be obtained. Minute to minute decisions about appropriate management can be made based on detection of changing cerebrovacular haemodynaamics. The same software has a major role in tyne management of hydrocephalus and other csf disorders. |
| Type Of Technology | Software |
| Year Produced | 2006 |
| Impact | ICM+ (http://www.neurosurg.cam.ac.uk/icmplus), which is by now used in many clinical centres worldwide, attempts to bridge the gap between laboratory and clinical application. It collects data from bedside monitors, calculates in real time 'secondary' parameters defined using highly configurable signal processing formulae and produces continuously updated charts. This way complex information coming off the bedside monitors can be summarized in a concise fashion and presented to medical staff in a simple way that alerts them to the development of various pathological processes. ICM+ software licensed by University of Cambridge Enterprise Ltd. [www.neurosurg.cam.ac.uk/icmplus |
| URL | http://www.neurosurg.cam.ac.uk/icm+home |
| Company Name | Technicam and Medicam |
| Description | www.technicam.co.uk Technicam Limited, a British company, was established in 2000 by a group of neurosurgeons and Centrax Limited of Newton Abbot, a precision engineering company. The aim of the company is the development of innovative advances in the field of surgical devices. All Technicam products are patent protected and CE marked. The Technicam Cranial Access Device has received an award as a Millenium Product for innovatio |
| Impact | The indications for skull burr-holes include insertion of intra-cranial bolts, insertion of exterior ventricular drains(ventriculostomies) , insertion of ventricular catheters for shunts , drainage of chronic subdural haematomas and access for brain biopsies. Burr-holes have been traditionally performed either by using air-powered drills or by hand using a brace, perforator and spherical burr. Recently the demand for cranial access via burr-holes has increased due to the application of monitoring probes, (intra-cranial) pressure transducers, oxygen and multi-parameter sensors and micro-dialysis catheters, and the increasing use of external ventricular drains in patients with head injury and subarachnoid haemorrhage. Traditionally, burr-holes have been performed in the operating theatre. By undertaking them on the intensive care unit, however, the complications of transferring the patient to the operating theatre can be avoided. Technicam have therefore developed a new cranial access system designed to simplify burr-holes, and facilitate the insertion of monitoring probes and external ventricular drains for use in the intensive care unit or the operating theatre - the Technicam Cranial Access System. |
| Website | http://www.technicam.co.uk |
| Description | Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Over 30,000 members of the public attend. Open to families and school groups etc. B.Sahakian - patron 2007 Very successful event as it combines fun and education. The support of the MRC is emphasised ast every appropriate opportunity. |
| Year(s) Of Engagement Activity | 2007,2008,2009,2010 |
| Description | Headway support groups |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | TBI patients attended lectures by DKM, JDP and PJAH. Mind your head i a crowd sourcing pilot that involvs the general public, business angels and the new University Technical College Headway invited patient groups to the lectures the outcomes of Mind your head is under review |
| Year(s) Of Engagement Activity | 2006,2007,2008,2010,2014 |
| Description | National Science Week |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 25 students from Cambridge school attended open- day talks on MRI and PET. School reported high interest. |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | National debates |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | DKM contributed substantially to the debate on the Mental Capacity Act, the EU Clinical trials Directive, the Data Protection Act and the Human Tissue Act. JDP has contributed to the Royal College Working Parties on Brain Death, Vegetative State and Mental Incapacity as well as providing advice to the Official Solicitor. All amendments, suggested at the committee stage have been incorporated into the respective acts and regulations, ensuring that acute brain injury research can continue. |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009 |
| Description | New Frontiers in Science Exhibition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | national exhibition Press release for WBIC |
| Year(s) Of Engagement Activity | 2006 |
| Description | Open Days |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Cambridgeshire schools attended one day presentations of MRI and PET by the WBIC N/A |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | Physics at Work |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | over 200 students from Cambridge area schools participate high participation from high schools |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010,2011,2012 |
| Description | Physics at Work programme |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | More than 200 pupils from Cambridge high schools attend. n/a |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010,2011,2012 |
| Description | Physics at Work programme |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | More than 200 pupils from Cambridge high schools attend. n/a |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010,2011 |
| Description | SCIENCE publication |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Our breakthrough publication (in Science) in collaboration with the MRC Cognition and Brain Sciences Unit demonstrated that it was possible to detect conscious awareness in patients suffering from persistent vegetative state (PVS) using neuro-imaging techniques (fMRI). This publication attracted an astonishing level of international attention from the news media and was widely discussed on TV, radio, in print and on line. Articles describing the work appeared in over 350 newspapers around the world and on multiple TV and radio reports. According to the MRC Press Office, this was the largest media response ever recorded to an MRC-funded scientific achievement Editorial commentaries on the work were published in several scientific journals, including Science and Nature |
| Year(s) Of Engagement Activity | 2006 |
| Description | Society of British Neurological Surgeons |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | JD Pickard Presicent and National Selection Working Party; Formerly member of Council, Proceedings Editor, WFNS/EANS representative, formerly Chairman, Intercollegiate Board in Surgical Neurology, member Joint Committee of Intercollegiate Examinations, Surgical Advisory Committee for Neurosurgery (Royal College of Surgeons Representative), Higher Surgical Training Committee (Royal College of Surgeons of England). as above |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009 |
| Description | Specialised Print media |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Contributed articles in the popular press and children's science magazines as well as more specialised print media including MRC News, television, raido and press interviews - often prompted by scientific publications, released by the University and Addenbrookes Press Offices and University website. Schools and media ask to visit. |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |