Wolfson Brain Imaging Centre (WBIC) COGG

Lead Research Organisation: University of Cambridge
Department Name: Wolfson Brain Imaging Centre

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50

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Achard S (2006) A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs. in The Journal of neuroscience : the official journal of the Society for Neuroscience

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Achard S (2007) Efficiency and cost of economical brain functional networks. in PLoS computational biology

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Allin DM (2006) In vitro hydrodynamic properties of the Miethke ProGAV hydrocephalus shunt. in Cerebrospinal fluid research

 
Description Brain Death Guidelines
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact JDP - Brain Death Guidelines Working Party (Royal College of Anaesthetists); liason with Official Solicitor over implications of advances in functional brain imaging for the management of patients in the vegetative state.
 
Description Home Office Animal Procedures Commitee and Primate Subcommittee
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact JDP - Home Office Animal Procedures Committee and Primate Subcommittee [Chairman]. Chairman of 'Pickard Report on Cumulative Severity and lifetime experience in non-human primates used in neuroscience research' published November 2013.
 
Description Management of incidentalomas identified in research brain scans of volunteers.
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact This ethical problem has now become a major issue - see recent Wellcome/SINAPSE ,meeting 2010 and Wardlaw report in BMJ 2015 referenced above
 
Description Mental Health Capacity
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact • DKM - Intensive care society: development of new legislation and regulations concerning Mental Capacity, Human Tissue Act, Clinical Trials Directive, data Protection Act.
 
Description A new collaborative ultra-high field MRI facility for dementia and neuroscience research - 7T MRI MRC Award: MR/M008983/1 PI: Prof J Rowe Total Award: £6,950,000
Amount £6,950,000 (GBP)
Funding ID MR/M008983/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2015 
End 03/2016
 
Description British Journal of Anaesthesia/Royal College of Anaesthetists project grant: Imaging
Amount £52,856 (GBP)
Organisation The Royal College of Anaesthetists 
Sector Academic/University
Country United Kingdom
Start  
 
Description Cambridge PET Neurochemist Programme
Amount £745,000 (GBP)
Funding ID G0900903 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Cerebral Energy Metabolism in Injured and Uninjured Brain
Amount £504,688 (GBP)
Funding ID G1002277 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Department of Health Technology Platform
Amount £1,896,880 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description EU Fellowship for Dr Jeroen Hermanides €
Amount € 97,727 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description EU Multicentre Project grant
Amount £300,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description Engineering and Physical Science High Resolution Simultaneous PET-MR Scanner. Awarded
Amount £1,082,585 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Evelyn Trust - Role of inflammation and neovasculatirsation in expansion of small AAA.
Amount £72,000 (GBP)
Organisation The Evelyn Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description IMAGEN Reinforcement-related behaviour in normal brain function and psychopathology
Amount £600,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description Imaging Theme co-applicant
Amount £6,700,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Cambridge Biomedical Research Centre
Sector Public
Country United Kingdom
Start  
 
Description Imaging inflammation in atherosclerosis: An integrated multimodality approach
Amount £1,139,380 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Imaging inflammation in atherosclerosis: an integrated multimodality approach
Amount £591,252 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Imaging mechanisms of energy failure following head injury.
Amount £220,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Imaging the surviving penumbra and recovery after stroke
Amount £843,000 (GBP)
Funding ID G0500874 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MICA: Detecting ictogenicity and epileptogenesis
Amount £1,635,366 (GBP)
Funding ID MR/L013215/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 03/2019
 
Description MICA: Training and Novel Probes Programme in PET Neurochemistry - PET Call
Amount £1,016,892 (GBP)
Funding ID MR/K02308X/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 12/2013 
End 11/2017
 
Description MRC - Decompressive Craniectomy Study
Amount £1,006,309 (GBP)
Funding ID G0601025 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC Acute Brain Imaging Collaborative Grant
Amount £1,357,662 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC Cambridge Centre for Behavioural and Clinical Neuroscience
Amount £1,815,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC programme Grant
Amount £775,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Multi-level patient-specific artery and athero-genesis model for outcome prediction, decision support treatment, and virtual hands-on training.
Amount £425,753 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description NIHR Biomedical research Centre
Amount £1,600,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Cambridge Biomedical Research Centre
Sector Public
Country United Kingdom
Start  
 
Description NIHR HTC for Brain Injury
Amount £800,000 (GBP)
Organisation Barts Health NHS Trust 
Department NIHR Biomedical Research Unit
Sector Academic/University
Country United Kingdom
Start 01/2013 
End 12/2017
 
Description Neurobiological correlates of trait impulsifvity an ddrug abuse vulnerability
Amount £1,134,962 (GBP)
Funding ID G0701500 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description New drugs for addiction: focus on attenuating core behavioural component of heroin, cocaine and alcohol addiction and relapse prevention.
Amount £1,774,000 (GBP)
Funding ID G1000018 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Novel Mitochondria-targeted PET probe
Amount £82,500 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description The British Oxygen Professorship: Imaging anaesthetic action in the brain.
Amount £320,943 (GBP)
Organisation The Royal College of Anaesthetists 
Sector Academic/University
Country United Kingdom
Start  
 
Description The Evelyn Trust. Cognitive disfunction after head injury:Neuroanatomical correlates and drug therapy/Evelyn Trust
Amount £120,400 (GBP)
Organisation The Evelyn Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description The HIF system in traumatic brain injury.
Amount £188,599 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Theme 1: Innovative Technologies for Stratified and Experimental Medicine MRC Award: MR/M009041/1 PI: Regius Professor P Maxwell Molecular Imaging Centre - £7,821,704 Sub-total: HPHI Informatics (WBIC) - £795,974
Amount £14,621,436 (GBP)
Funding ID MR/M009041/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2015 
End 03/2016
 
Description Towards a biomechanics-based vulnerability assessment tool for carotid atherosclerotic plaque: mechanical property testing and MRI-based computaional modelling
Amount £193,818 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Vegetative State
Amount $500,000 (USD)
Organisation James S. McDonnell Foundation 
Sector Charity/Non Profit
Country United States
Start 08/2013 
End 07/2017
 
Title MICL 
Description Establishment of the Molecular Imaging Chemistry Laboratory at Forvie Site, Cambridge Biomedical Campus, Cambridge (2008): a dedicated facility for the development, synthesis and evaluation of novel imaging probes. 
Type Of Material Improvements to research infrastructure 
Year Produced 2013 
Provided To Others? Yes  
Impact Major new grants to support dementia initiative 
 
Title Microfluidic methods for PET radiopharmaceuticals 
Description Development of microfluidic methods for the preparation of PET radiopharmaceuticals 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact TBD 
 
Title Novel 11C-METHIONINE PET for pituitary micro adenomas 
Description Functioning pituitary micro adenomas can be very difficult to identify on conventional MR scanning. Dr Mark Gurnell, Dr Franklin AIgbirhio and Professor Pickard in collaboration with colleagues have developed a PET imaging technique based on 11C-Methionine based on an initial contribution of £10000 from JDP's Senior Investigator Award.The Cambridge Pituitary MDT Clinic now attracts tertiary referrals from throughout the UK and abroad for this technique. Oral/pleanry presentations have been given in San Francisco, Sydney and Munich. 3 major papers are in preparation. 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact A very difficult group of patients with refractory functioning pituitary micoadenomas are now being offered highly selective endoscopic re-do pituitary operations thereby improving outcomes and reducing the need for expensive and ineffective drug therapies. 
 
Title functional MR and EEG paradigms for assessment of covert awareness 
Description Study of patients in low awareness states requires the development of psychological paradigms that can be applied in brain scanners including PET and MR. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2006 
Provided To Others? Yes  
Impact Major papers in Science, NEJM and worldwide publicity 
 
Description Altered States of Consciousness - International Collaborations 
Organisation Cornell University
Country United States 
Sector Academic/University 
PI Contribution Pickard JD: Collaobrations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor.
Impact See publications lists and new grants.
 
Description Altered States of Consciousness - International Collaborations 
Organisation Royal College of Physicians of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Pickard JD: Collaobrations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor.
Impact See publications lists and new grants.
 
Description Altered States of Consciousness - International Collaborations 
Organisation The Royal College of Anaesthetists
Country United Kingdom 
Sector Academic/University 
PI Contribution Pickard JD: Collaobrations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor.
Impact See publications lists and new grants.
 
Description Altered States of Consciousness - International Collaborations 
Organisation University of Liege
Country Belgium 
Sector Academic/University 
PI Contribution Pickard JD: Collaobrations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor.
Impact See publications lists and new grants.
 
Description Altered States of Consciousness - International Collaborations 
Organisation University of Melbourne
Country Australia 
Sector Academic/University 
PI Contribution Pickard JD: Collaborations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor
Impact See publications lists and new grants.
 
Description Application of PET in addiction research 
Organisation University of Cambridge
Department Department of Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Application of PET in addiction research.
Impact n/a
Start Year 2010
 
Description Council of Intensive Care Society 
Organisation Intensive Care Society
Country United Kingdom 
Sector Learned Society 
PI Contribution D.K Menon: Council of the Intensive Care Society - special respnsibility for the development of new legislation and regulations concerning Menal Capacity, Human Tissue Act, Clinical trials Directive and Data Protection Act. 2003 - 2009
Impact Submission of input into grant from Department of Constitutional Affairs which led to a booklet being provided on the Society for Intensive Care Website.
 
Description Development of novel fluorination method 
Organisation Newcastle University
Department School of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Development of novel fluorination method using iodonium compounds
Impact tba
Start Year 2009
 
Description ERASMUS Exchange Programme 
Organisation University of Groningen
Department Department of Biomedical Engineering
Country Netherlands 
Sector Academic/University 
PI Contribution We provided human resources and research infrastructure for MSc students
Collaborator Contribution MSc students
Impact Publications
Start Year 2011
 
Description ERASMUS Exchange Programme 
Organisation University of Lisbon
Department Institute of Biophysics and Biomedical Engineering
Country Portugal 
Sector Academic/University 
PI Contribution We provided human resources and research infrastructure for MSc students
Collaborator Contribution MSc students
Impact Publications
Start Year 2011
 
Description ICNARC and NCCnet 
Organisation Queen's Medical Centre
Country United Kingdom 
Sector Hospitals 
PI Contribution ICNARC and NCCnet: Professor of Anaesthesia serves on the Management Board of the UK Intensive Care National Audit and Research Centre (ICNARC), and is Project Lead for NCCNet (http://www.nccnet.org.uk) - a research collaborative of UK neurocritical care units.
Impact A collaboration that included ICNARC and NCCNet was recently awarded a £595,000 grant from the HTA.
Start Year 2011
 
Description International Fellows 
Organisation University of Melbourne
Country Australia 
Sector Academic/University 
PI Contribution Steiner (Basal), Abate (Milan), Owler (Sydney), Zegan (Calgary), Gallagher (Calgary), Lewis (Melbourne) University of Melbeurne (Phil Lewis), Eric Schmidt (Toulouse), Jager (Leipzig), Momjian (Geneva), Lavinio (Brescia), Petrella (Rome), Balestreri (Pavia), Soehle (Bonn).
Impact See publication listing
Start Year 2006
 
Description MR Elastography 
Organisation Charité - University of Medicine Berlin
Country Germany 
Sector Academic/University 
PI Contribution We implemented and tested MRE equipment and methods on a 3T system. Developed an add-on for the image acquisition that allows automatic in-line analysis.
Collaborator Contribution Delivered the concept for equipment and method and offered expertise in the clinical use of the methods
Impact Constant improve of image acquisition and analysis methods.
Start Year 2009
 
Description MR Elastography 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution We implemented and tested MRE equipment and methods on a 3T system. Developed an add-on for the image acquisition that allows automatic in-line analysis.
Collaborator Contribution Delivered the concept for equipment and method and offered expertise in the clinical use of the methods
Impact Constant improve of image acquisition and analysis methods.
Start Year 2009
 
Description Mitochondrial PET Probes 
Organisation Medical Research Council (MRC)
Department MRC Mitochondrial Biology Unit
Country United Kingdom 
Sector Public 
PI Contribution Radiosynthesis and biological evaluation of the PET radioligands
Collaborator Contribution Novel PET probes. Synthesis and biological evaluation of novel chemical entities.
Impact PMID: 20621583
Start Year 2008
 
Description Non-invasive assessment of intracranial pressure 
Organisation Albert Ludwigs University of Freiburg
Country Germany 
Sector Hospitals 
PI Contribution Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang).
Impact See publications listing
Start Year 2006
 
Description Non-invasive assessment of intracranial pressure 
Organisation Chemnitz Academic Teaching Hospital
Department Department of Neurology
Country Germany 
Sector Hospitals 
PI Contribution Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang).
Impact See publications listing
Start Year 2006
 
Description Non-invasive assessment of intracranial pressure 
Organisation University of Kiel
Department Department of Neurosurgery
Country Germany 
Sector Academic/University 
PI Contribution Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang).
Impact See publications listing
Start Year 2006
 
Description Non-invasive assessment of intracranial pressure 
Organisation University of Memphis
Department Medical Engineering Memphis
Country United States 
Sector Academic/University 
PI Contribution Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang).
Impact See publications listing
Start Year 2006
 
Description Novel Copper-64 
Organisation University of Bath
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Novel Copper-65 molecular imaging probes
Impact tba
Start Year 2008
 
Description Novel PET probes 
Organisation Medical Research Council (MRC)
Department MRC Clinical Sciences Centre (CSC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Development of novel PET probes of mitochondirial dysfunction
Impact tba
Start Year 2009
 
Description Novel PET probes 
Organisation University of Otago
Country New Zealand 
Sector Academic/University 
PI Contribution Development of novel PET probes of mitochondirial dysfunction
Impact tba
Start Year 2009
 
Description Novel copper-64 
Organisation University of Oxford
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Development of Copper-64 hypoxia markers
Impact tba
Start Year 2007
 
Description PET in stroke research 
Organisation University of Cambridge
Department School of Clinical Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Application of PET in Stroke Research with Prof Jean-Claude Baron of Neurology/Stroke
Impact see publications listing
 
Description Siemens MRI 
Organisation Siemens Healthcare
Department Siemens Medical Solutions
Country Germany 
Sector Private 
PI Contribution Development of pulse sequences for use on Siemens MRI systems
Collaborator Contribution Provision of the software development environment. Access to collaboration manager.
Impact Improved pulse sequences for diffusion modelling and real-time fMRI
Start Year 2006
 
Description Siemens Molecular Imaging 
Organisation Siemens Healthcare
Department Siemens Medical Solutions
Country Germany 
Sector Private 
PI Contribution Research collaboration in the development of PET probes for neurodegeneration.
Impact tba
Start Year 2009
 
Title ICM+ software 
Description Software that allows the collection of data from multimodlaity bedside monitors in neurointensive care and subsequent analysis in real time. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted
Licensed Yes
Impact ICM+ is the basis of a multinational collaboration of worldclass neurointensive care units.
 
Title 18F labelled endothelin and urotensin-II 
Description Automated synthesis of the generic peptide labelling agent N-succinimidyl 4-[(18)F]fluorobenzoate for synthesis of 18F labelled peptides for clinical use and application to (18)F-label to vasoactive transmitters endothelin and urotensin-II as ligands for positron emission tomography. 
Type Diagnostic Tool - Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2007
Development Status On hold
Impact Publication of method has been adopted by others for synthesis of peptides for clinical use. 
 
Title ICMplus 
Description ICM+ software [www.neurosurg.cam.ac.uk/icmplus]. ICM+ captures the enormous quantities of physiological data from each patient in an neurointensive care environment form which information about cerebral auto regulation, cerebral compensatory reserve, oxygenation, metabolite production and function can be obtained. Minute to minute decisions about appropriate management can be made based on detection of changing cerebrovacular haemodynaamics. The same software has a major role in tyne management of hydrocephalus and other csf disorders. 
Type Of Technology Software 
Year Produced 2006 
Impact ICM+ (http://www.neurosurg.cam.ac.uk/icmplus), which is by now used in many clinical centres worldwide, attempts to bridge the gap between laboratory and clinical application. It collects data from bedside monitors, calculates in real time 'secondary' parameters defined using highly configurable signal processing formulae and produces continuously updated charts. This way complex information coming off the bedside monitors can be summarized in a concise fashion and presented to medical staff in a simple way that alerts them to the development of various pathological processes. ICM+ software licensed by University of Cambridge Enterprise Ltd. [www.neurosurg.cam.ac.uk/icmplus 
URL http://www.neurosurg.cam.ac.uk/icm+home
 
Company Name Technicam and Medicam 
Description www.technicam.co.uk Technicam Limited, a British company, was established in 2000 by a group of neurosurgeons and Centrax Limited of Newton Abbot, a precision engineering company. The aim of the company is the development of innovative advances in the field of surgical devices. All Technicam products are patent protected and CE marked. The Technicam Cranial Access Device has received an award as a Millenium Product for innovatio 
Impact The indications for skull burr-holes include insertion of intra-cranial bolts, insertion of exterior ventricular drains(ventriculostomies) , insertion of ventricular catheters for shunts , drainage of chronic subdural haematomas and access for brain biopsies. Burr-holes have been traditionally performed either by using air-powered drills or by hand using a brace, perforator and spherical burr. Recently the demand for cranial access via burr-holes has increased due to the application of monitoring probes, (intra-cranial) pressure transducers, oxygen and multi-parameter sensors and micro-dialysis catheters, and the increasing use of external ventricular drains in patients with head injury and subarachnoid haemorrhage. Traditionally, burr-holes have been performed in the operating theatre. By undertaking them on the intensive care unit, however, the complications of transferring the patient to the operating theatre can be avoided. Technicam have therefore developed a new cranial access system designed to simplify burr-holes, and facilitate the insertion of monitoring probes and external ventricular drains for use in the intensive care unit or the operating theatre - the Technicam Cranial Access System.
Website http://www.technicam.co.uk
 
Description Cambridge Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Over 30,000 members of the public attend. Open to families and school groups etc.
B.Sahakian - patron 2007

Very successful event as it combines fun and education. The support of the MRC is emphasised ast every appropriate opportunity.
Year(s) Of Engagement Activity 2007,2008,2009,2010
 
Description Headway support groups 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact TBI patients attended lectures by DKM, JDP and PJAH.
Mind your head i a crowd sourcing pilot that involvs the general public, business angels and the new University Technical College

Headway invited patient groups to the lectures
the outcomes of Mind your head is under review
Year(s) Of Engagement Activity 2006,2007,2008,2010,2014
 
Description National Science Week 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 25 students from Cambridge school attended open- day talks on MRI and PET.

School reported high interest.
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description National debates 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact DKM contributed substantially to the debate on the Mental Capacity Act, the EU Clinical trials Directive, the Data Protection Act and the Human Tissue Act.
JDP has contributed to the Royal College Working Parties on Brain Death, Vegetative State and Mental Incapacity as well as providing advice to the Official Solicitor.

All amendments, suggested at the committee stage have been incorporated into the respective acts and regulations, ensuring that acute brain injury research can continue.
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description New Frontiers in Science Exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact national exhibition

Press release for WBIC
Year(s) Of Engagement Activity 2006
 
Description Open Days 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Schools
Results and Impact Cambridgeshire schools attended one day presentations of MRI and PET by the WBIC

N/A
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description Physics at Work 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact over 200 students from Cambridge area schools participate

high participation from high schools
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description Physics at Work programme 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact More than 200 pupils from Cambridge high schools attend.

n/a
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description Physics at Work programme 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact More than 200 pupils from Cambridge high schools attend.

n/a
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description SCIENCE publication 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Our breakthrough publication (in Science) in collaboration with the MRC Cognition and Brain Sciences Unit demonstrated that it was possible to detect conscious awareness in patients suffering from persistent vegetative state (PVS) using neuro-imaging techniques (fMRI). This publication attracted an astonishing level of international attention from the news media and was widely discussed on TV, radio, in print and on line. Articles describing the work appeared in over 350 newspapers around the world and on multiple TV and radio reports. According to the MRC Press Office, this was the largest media response ever recorded to an MRC-funded scientific achievement

Editorial commentaries on the work were published in several scientific journals, including Science and Nature
Year(s) Of Engagement Activity 2006
 
Description Society of British Neurological Surgeons 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact JD Pickard Presicent and National Selection Working Party; Formerly member of Council, Proceedings Editor, WFNS/EANS representative, formerly Chairman, Intercollegiate Board in Surgical Neurology, member Joint Committee of Intercollegiate Examinations, Surgical Advisory Committee for Neurosurgery (Royal College of Surgeons Representative), Higher Surgical Training Committee (Royal College of Surgeons of England).

as above
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description Specialised Print media 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Contributed articles in the popular press and children's science magazines as well as more specialised print media including MRC News, television, raido and press interviews - often prompted by scientific publications, released by the University and Addenbrookes Press Offices and University website.

Schools and media ask to visit.
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010