Cognitive impairment in schizophrenia - a clinical, imaging and genetic study of co-morbidity

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Molecular. Genetics & Pop Health

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Harris JM (2008) Autistic traits and cognitive performance in young people with mild intellectual impairment. in Journal of autism and developmental disorders

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Johnstone EC (2007) Schizotypal cognitions as a predictor of psychopathology in adolescents with mild intellectual impairment. in The British journal of psychiatry : the journal of mental science

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Lawrie SM (2012) Predicting first episode psychosis in those at high risk for genetic or cognitive reasons. in Epidemiology and psychiatric sciences

 
Description Dorothy Hodgkin Fellowship
Amount £475,016 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Dr Mortimer and Theresa Sackler Foundation
Amount £750,000 (GBP)
Organisation Dr Mortimer and Theresa Sackler Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description R.S.Macdonald Trust
Amount £27,500 (GBP)
Organisation RS Macdonald Charitable Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Title Automated Region of Interest 
Description In our assessment of the presentation of brain structure in the cognitive impairment cohort we have extended our automated techniques to the extraction lobar and sub-lobar volumes. These allow us to assess for large cohorts volumes of the prefrontal and temporal lobes and sub divisions of these lobes. 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact We are applying these automated ROI measures to the large cohorts acquired by the Division of Psychiatry. These cohorts are well characterised and the records that are diligently maintained. In due course we will report on the longitudinal changes in lobar volumes that are associated with increased risk of psychosis. 
 
Title Cluster Based Inference 
Description We developed non-isotropic smoothness correction for VBM reporting. This allows for cluster based inferences in structural imaging reports, and extends the established VBM methods which were otherwise restricted to maximal voxel reports. This was an important factor in our reporting of the cross-sectional differences on the cognitive impairment cohort. 
Type Of Material Data analysis technique 
Year Produced 2006 
Provided To Others? Yes  
Impact We were the first group to apply and report on this technique to structural MRI and the method has been developed by Hayasaka into an SPM Toolbox. http://fmri.wfubmc.edu/cms/NS-General. We have applied this technique to our continuing studies of schizophrenia and bipolar disorder. 
URL http://fmri.wfubmc.edu/cms/NS-General
 
Title Tensor Based Morphometry 
Description The Division of Psychiatry in Edinburgh is one of the groups world-wide who are leading the introduction of new automated means to assess MRI brain scans. Our Automated-Gyrification Index (A-GI) software allows us to assess cortical folding. This employs Artificial Intelligence (AI) methods to replicate the gold-standard of hand tracings but with automated techniques that are quicker and more reliable 
Type Of Material Data analysis technique 
Year Produced 2008 
Provided To Others? Yes  
Impact In our current research we have found that measures of the folding characteristics in the frontal lobes of the brain are strongly predictive of schizophrenia onset and are sensitive to disease progression. These measures also demonstrate separation between controls and autistic spectrum disorder and obsessive compulsive disorder and bipolar disorder, and each condition has a different profile within the pre-frontal lobes. Our latest findings using a development of this method reveal the mechanism by which schizophrenia develops in some symptomatic high risk subjects and not others. 
 
Title Voxelwise inter subject co-registration 
Description The cognitive impairment cohort exhibited high variability in the structural brain presentations, and established VBM registration techniques gave poor co-registration. Thus we developed our extracted brain normalisation technique and this was applied throughout our reports from the cohort. In order to run this normalisation we developed an automated brain extraction tool that applied a manual protocol in a machine process. This gave an efficient implementation of a high quality brain extraction which was equivalent to that obtainable through manual tracing. 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact The technical developments that improved brain co-registration have been applied to our continuing studies of psychosis that employ VBM. These developments have been applied to our analyses of genes and psychosis and to our study of bipolar disorder over time. 
 
Description Thirty Plus Years of Schizophrenia Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Invited speaker at principle meeting on schizophrenia in Venice. Audience scientists dealing with schizophrenia.

Numerous requests for further details of study.
Year(s) Of Engagement Activity 2008
 
Description WHAT CAN THE EDINBURGH COHORT STUDIES TELL US ABOUT NEURODEVELOPMENTAL AND PSYCHIATRIC DISORDERS? 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Winter Conference on Brain Research, Snowbird 2008-Neurodevelopmental features of schizophrenia, genetic, molecular and clinical studies.

Offer from Sackler Foundation to submit for futher funding.
Year(s) Of Engagement Activity 2008