Molecular mechanisms of monogenic epilepsies and related movement disorders

Lead Research Organisation: University College London
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description Action Research training fellowship for TG
Amount £150,000 (GBP)
Organisation Action Medical Research 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2007 
End 07/2008
 
Description Engineered Potassium Channel gene therapy for epilepsy
Amount £2,200,000 (GBP)
Funding ID MR/R015333/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 04/2022
 
Description Innovator Award: Glutamate-gated chloride channel treatment of epilepsy
Amount £456,266 (GBP)
Funding ID 209807/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2018 
End 09/2020
 
Description MRC Centre Grant: Centre for Neuromuscular Disease
Amount £3,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2008 
End 09/2012
 
Description MRC grant: Lentiviral potassium channel expression to treat focal neocortical epilepsy
Amount £1,008,392 (GBP)
Funding ID G0802158 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2009 
End 08/2012
 
Description Wellcome Trust training fellowship for SR
Amount £150,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2007 
End 07/2009
 
Description Wellcome trust grant: Virally-delivered shRNA for focal epilepsy
Amount £242,321 (GBP)
Funding ID 086882 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2009 
End 07/2012
 
Title Clones, viral constructs 
Description Several cDNAs were generated 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2008 
Provided To Others? Yes  
Impact The viral vectors have allowed manipulation of neuronal activity 
 
Description Creation of MRC Centre for Neuromuscular Diseases 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution I am on the steering committee and help to co-ordinate the seminar programme and the use of animals. My laboratory offers rotations to students on the PhD programme.
Collaborator Contribution The MRC Centre for Neuromuscular Diseases has capitalised on the channelopathy research that was sponsored by the grant, and has facilitated interactions across a wide community of researchers across UCL and the University of Newcastle
Impact Several papers have resulted
Start Year 2008
 
Title Sequencing DNA analysis for CACNA1A, CLCN1 mutations 
Description Sequencing analysis is now offered for mutations through the channelopathy service at the National Hospital/UCL Institute of Neurology 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2008
Development Status Under active development/distribution
Impact Improved diagnosis of patients with channelopathies 
 
Description School visits 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Pupils at schools sponsored by the Worshipful Company of Pewterers participated in several Science Days run by one of the researchers funded by the grant.

Repeated invitations, nomination for public engagement awards
Year(s) Of Engagement Activity 2006,2007,2008,2009