Biochemical characterisation of pivotal enzymes involved in mycobacterial mycolic acid biosynthesis
Lead Research Organisation:
University of Birmingham
Department Name: Sch of Biosciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Alderwick LJ
(2007)
Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new drug targets.
in Biochemical Society transactions
Bhatt A
(2007)
The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development.
in Molecular microbiology
Bhatt A
(2007)
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.
in Proceedings of the National Academy of Sciences of the United States of America
Brown AK
(2007)
Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex.
in Microbiology (Reading, England)
Brown AK
(2007)
Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.
in Microbiology (Reading, England)
Dover LG
(2007)
Regulation of cell wall synthesis and growth.
in Current molecular medicine
Gande R
(2007)
The two carboxylases of Corynebacterium glutamicum essential for fatty acid and mycolic acid synthesis.
in Journal of bacteriology
Ghadbane H
(2007)
Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT).
in Acta crystallographica. Section F, Structural biology and crystallization communications
Sridharan S
(2007)
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).
in Journal of molecular biology
| Description | Research Grant |
| Amount | £420,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2006 |
| End | 10/2009 |
| Description | Research Grant |
| Amount | £404,224 (GBP) |
| Funding ID | G0901690 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2010 |
| End | 05/2013 |
| Description | The Mycobacterium tuberculosis Cell Envelope: unravelling complex cell wall assembly, degradation and re-cycling pathways |
| Amount | £1,720,866 (GBP) |
| Funding ID | MR/S000542/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 02/2024 |
| Description | BCG Vaccine and problems? |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | BBC Inside Out None |
| Year(s) Of Engagement Activity | 2007 |
| Description | New TB Drugs |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview for BBC Inside Out. None |
| Year(s) Of Engagement Activity | 2007 |
| Description | New TB drug targets and vaccines |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | An interview with the BBC Inside Out show. None |
| Year(s) Of Engagement Activity | 2007 |
| Description | New TB drugs and vaccines? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with the BBC and Inside Out Show for the West Midlands. None |
| Year(s) Of Engagement Activity | 2007 |
| Description | New TB drugs? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview and presentation for the BBC Inside Out None |
| Year(s) Of Engagement Activity | 2007 |