Centre for Stem Cell Research
Lead Research Organisation:
University of Edinburgh
Department Name: Sch of Biological Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- University of Edinburgh, United Kingdom (Collaboration, Lead Research Organisation)
- University College London, United Kingdom (Collaboration)
- University of California, Berkeley (Collaboration)
- Institute for Research on the Spinal Cord and Brain (IRME) (Collaboration)
- Utrecht University (Collaboration)
- Peter MacCallum Cancer Centre, Australia (Collaboration)
- Syntaxin (Collaboration)
- Lamellar Biomedical Ltd, United Kingdom (Collaboration)
- Royal Netherlands Academy of Arts and Sciences (Collaboration)
- Life Technologies (Collaboration)
- Stem Cell Technologies (Collaboration)
- Helmholtz Association of German Research Centres (Collaboration)
- University of Liverpool, United Kingdom (Collaboration)
- Novartis (Collaboration)
- Multiple Sclerosis Society (Collaboration)
- Babraham Institute (Collaboration)
- Stanford University, United States (Collaboration)
- Stem Cells for Safer Medicines (SC4SM) (Collaboration)
- Pasteur Institute, Paris (Collaboration)
- European Commission, Belgium (Collaboration)
- Mount Sinai Hospital (Canada) (Collaboration)
- University of Nottingham (Collaboration)
- Primorigen Biosciences (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- University of South Australia, Australia (Collaboration)
- Uppsala University (Collaboration)
- Erasmus University Rotterdam (EUR) (Collaboration)
- University of Texas at San Antonio, United States (Collaboration)
- University of Cambridge, United Kingdom (Collaboration)
- Medical Research Council (Collaboration)
- National Institutes of Health, United States (Collaboration)
- San Raffaele del Monte Tabor Foundation (Collaboration)
- University of Surrey, United Kingdom (Collaboration)
- McGill University, Canada (Collaboration)
- Bristol-Myers Squibb (Collaboration)
- Cellartis AB (Collaboration)
- Pfizer Ltd (Collaboration)
- Multicell Technologies (Collaboration)
- Hull York Medical School (Collaboration)
- King's College London, United Kingdom (Collaboration)
- University of Leicester, United Kingdom (Collaboration)
Publications
Blelloch R
(2006)
Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus.
in Stem cells (Dayton, Ohio)
Bredenkamp N
(2014)
An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts.
in Nature cell biology
Bredenkamp N
(2014)
Regeneration of the aged thymus by a single transcription factor.
in Development (Cambridge, England)
Chambers I
(2007)
Nanog safeguards pluripotency and mediates germline development.
in Nature
Depreter MG
(2008)
Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells.
in Proceedings of the National Academy of Sciences of the United States of America
Foster K
(2008)
Contribution of neural crest-derived cells in the embryonic and adult thymus.
in Journal of immunology (Baltimore, Md. : 1950)
Foukas LC
(2006)
Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.
in Nature
Garrick D
(2006)
Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.
in PLoS genetics
| Description | BMJ Editorial on stem cells in MS, 2010 |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | NK |
| Description | Book chapter on human-animal chimeras, collaboration with Neville Cobbe. |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | NK |
| Description | Characterisation of large pre-existing hybridoma panel on human and zebrafish embryonic tissue, funding in place from Bioquarter (UoE/SE) to characterise antibodies particularly with regard to those recognising lineage markers in zebrafish, antibodies to be freely available to zebrafish community and hybridomas to be licensed by UoE. |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | antibodies to be freely available to zebrafish community and hybridomas to be licensed by UoE. Possible contribution to spin-out company from UoE |
| Description | Development of multi-modal contrast agents for imaging and gene delivery |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | available to research community, collaborators in Edinburgh include CVS, CRB |
| Description | Inverkeithing High School and others very keen to repeat the SSCN roadshow and for it to become a regular part of the school's commitment to the curriculum for excellence |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Public outreach |
| Description | Monthly MS Discussion Group for Neurologists in SE Scotland |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Discussion of clinical cases, current research etc. 2008-continues. Very successful in providing clinical support, propagating important research findings and general clinical policies throughout our catchment area. |
| Description | Myelinating co-culture technologies |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Myelinating co-culture technologies, for which we receive at least one request/month for protocols or training |
| Description | Participation in British Council funded Latin America PhD student course 'ES cells as a model system for embryonic development' in Sao Paulo, Brazil [February 2009]. |
| Geographic Reach | North America |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | NK |
| Description | Prevalence register for patients in Scotland. |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Impact | Have contributed to the momentum that led to the Scottish Governments agreement to fund a prevalence register for patients in Scotland. |
| Description | Research materials. |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Research materials. |
| Description | Scientific Advisory Board for the Scottish Universities Environmental Research Centre (SUERC) |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in advisory committee |
| Impact | Appointed to the Scientific Advisory Board for the Scottish Universities Environmental Research Centre (SUERC) from 2010. |
| Description | 089000/Z/09/Z Wellcome Trust Programme Grant (Axoglial interactions during myelination in the CNS) PIs Brophy and French-Constant |
| Amount | £1,610,619 (GBP) |
| Funding ID | 089000/Z/09/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2008 |
| End | 07/2013 |
| Description | AHMRC CJ Martin Fellowship /AHMRC |
| Amount | £1 (GBP) |
| Organisation | National Health and Medical Research Council |
| Sector | Public |
| Country | Australia |
| Start | 05/2009 |
| End | 04/2012 |
| Description | ALLOSTEM: The Development of Immunotherapeutic Strategies to Treat Haematological and Neoplastic diseases on the Baiss of Optimised Allogeneic Stem Cell Transplantation (8m euros across 29 participants) |
| Amount | £13,000 (GBP) |
| Funding ID | 503319 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 04/2004 |
| End | 03/2008 |
| Description | Analysis of cellular mechanisms underlying haematopoietic |
| Amount | £1 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | BBSRC Stem Cells Initiative Project Grant |
| Amount | £1 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | BBSRC funding (Generating models of nurtitional programming) |
| Amount | £1,300,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2014 |
| Description | BEST-Stem Cells: Bio-chemically Equivalent Substitutive Technology for Stem Cells (MGMT-budget CMVM) |
| Amount | £300,000 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 07/2009 |
| End | 06/2012 |
| Description | BEST-Stem Cells: Bio-chemically Equivalent Substitutive Technology for Stem Cells (RTD-budget CMVM) |
| Amount | £650,000 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 07/2009 |
| End | 06/2012 |
| Description | BHF Project Grant |
| Amount | £1 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | BHF Project Grant PG/05/077/18240 (Mechanisms of acclerated atherogenesis and sudden death in an ApoE-/- / 11HSD2-/- double knockout mouse) PI Dr Y V Kotelevtsev |
| Amount | £184,858 (GBP) |
| Funding ID | PG/05/077/18240 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2004 |
| End | 12/2006 |
| Description | Biotechnology and Biological Sciences Research Council (BBSRC)-Identification of Functional Domains in the AGM Region linked to the hierarchical organisation of the developing haematopoietic stem cell lineage |
| Amount | £1,600,000 (GBP) |
| Organisation | CHDI Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 09/2010 |
| End | 08/2013 |
| Description | Biotechnology and Biological Sciences Research Council (BBSRC)-Integrating developmental pathways and chromatin structure during lineage specification |
| Amount | £460,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Biotechnology and Biological Sciences Research Council (BBSRC)-Steroid Receptors and transcriptional control of thymic rebound |
| Amount | £600,000 (GBP) |
| Funding ID | BB/H021183/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2010 |
| End | 08/2013 |
| Description | CASE Studentship (Stem Cell Sciences)/stem cell sciences |
| Amount | £1 (GBP) |
| Organisation | Babraham Institute |
| Department | Stem Cell Sciences UK Ltd |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Cancer Research UK-Function of the C/EBPâ-CyclinD1 complex in epithelial cancers |
| Amount | £275,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | Cancer Research UK-Identification of genes required for the maintenance of AML cancer stem cells |
| Amount | £300,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2013 |
| Description | Daphne Jackson Trust-Fellowship for Joanna Brzeszcyzynska: miRNAs role in muscle pathphysiology of cancer cachexia |
| Amount | £41,000 (GBP) |
| Organisation | University of Surrey |
| Department | Daphne Jackson Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2013 |
| Description | EPSRC funding (Screening polymer libraries using hESC-derived hepatic endoderm) |
| Amount | £250,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | ESTOOLS (12m euros across 23 participants) |
| Amount | £427,826 (GBP) |
| Funding ID | 18739 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 07/2006 |
| End | 07/2010 |
| Description | EU Consortium for Stem Cell Biology |
| Amount | £1 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 05/2009 |
| End | 04/2012 |
| Description | EU Consortium for Stem Cell Biology/EU Consortium |
| Amount | £1 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 05/2009 |
| End | 04/2012 |
| Description | EUROSTEMCELL-European consortium for communication of stem cell research/eurostemcell (0.8m euros across 11 participants) |
| Amount | £61,890 (GBP) |
| Funding ID | 241878 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 03/2010 |
| End | 02/2014 |
| Description | Engineering and Physical Sciences Research Council (EPSRC)-Bio-Active Polymer Driven Cell Based Systems - Predicting Human Drug Toxicity |
| Amount | £130,000 (GBP) |
| Funding ID | EP/H029680/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | European Commission (EC)-EuroStemCell: European Consortium for Communicating Stem Cell Research/euorpean commission (EC) |
| Amount | £516,000 (GBP) |
| Funding ID | 241878 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 09/2010 |
| End | 08/2013 |
| Description | European Commission/Marie Curie - Intra-European Fellowship-GRNES: Analysis of the gene regulatory network controlling ES cell identity/European Commission/Marie Curie - Intra-European Fellowship |
| Amount | £140,000 (GBP) |
| Funding ID | 254979 |
| Organisation | Marie Sklodowska-Curie Actions |
| Sector | Academic/University |
| Country | Global |
| Start | |
| Description | Foreign & Commonwealth Office-UK-US Stem Cell Collaboration Award/Foreign & Commonwealth Office |
| Amount | £2,400 (GBP) |
| Organisation | Foreign and Commonwealth Office (FCO) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Gamma irradiation sources for studies on stem cell and immune cell function |
| Amount | £1 (GBP) |
| Funding ID | 084537 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Generating models of hepatic endoderm from hESCs suitable for industrial application |
| Amount | £180,000 (GBP) |
| Organisation | Stem Cells for Safer Medicines (SC4SM) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | JDRF Pilot Project |
| Amount | £1 (GBP) |
| Organisation | Juvenile Diabetes Research Foundation (JDRF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | JDRF Pilot Project |
| Amount | £1 (GBP) |
| Organisation | Juvenile Diabetes Research Foundation (JDRF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Knowledge Transfer Partnership-Estimate of 2 year project between Roslin Cellab and University of Edinburgh/knowledge transfer partnership |
| Amount | £95,000 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2012 |
| Description | LRF Project Grant |
| Amount | £1 (GBP) |
| Organisation | Leukaemia and Lymphoma Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | LRF Senior Fellowship |
| Amount | £1 (GBP) |
| Organisation | Leukaemia and Lymphoma Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Leukaemia Research (Directing differentiation of Mouse and human embryonic stem cells into haematopoietic stem cells (HSC) using engineered embryonic HSC niches) |
| Amount | £1,350,000 (GBP) |
| Organisation | Leukaemia and Lymphoma Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Leukaemia Research (Ex vivo expansion of human haematopoietic stem cells from the embryonic AGM region) |
| Amount | £219,600 (GBP) |
| Organisation | Leukaemia and Lymphoma Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2008 |
| End | 04/2011 |
| Description | Leukaemia Research Foundation-In vitro propagation of mouse and human fetal thymic epithelial progenitor cells/Leukaemia Research Foundation |
| Amount | £190,000 (GBP) |
| Organisation | Leukaemia and Lymphoma Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | Leukaemia Research Foundation-Molecular and Cellular Analysis of Thymic Epithelial Progenitor Cells |
| Amount | £40,000 (GBP) |
| Organisation | Leukaemia and Lymphoma Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | MRC Collaborative Studentship (partner Stem Cell Sciences) |
| Amount | £1 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | MRC Project Grant (G0400690) |
| Amount | £1 (GBP) |
| Funding ID | G0400690 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | MRC Research Grant (Studying transplantation of hESC-derived hepatic endoderm into animal models) |
| Amount | £500,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | MRC iPS supplemental award |
| Amount | £50,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | MS Hope For A Cure-Autologous cell therapy - a neuroprotective strategy for MS/MS Hope for a Cure |
| Amount | £51,500 (GBP) |
| Organisation | MS Hope for a Cure |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Marie Curie Initial Training Network NotchIT |
| Amount | £310,000 (GBP) |
| Funding ID | 215761 |
| Organisation | Marie Sklodowska-Curie Actions |
| Sector | Academic/University |
| Country | Global |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Medical Research Council (MRC)-ANALYSIS OF MECHANISMS OF EARLY HAEMATOPOIETIC STEM CELL DEVELOPMENT CONTROLLED BY FLK1/SCL REGULATORY NETWORK |
| Amount | £300,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2013 |
| Description | Medical Research Council (MRC)-ANALYSIS OF MECHANISMS OF EARLY HAEMATOPOIETIC STEM CELL DEVELOPMENT CONTROLLED BY FLK1/SCL REGULATORY NETWORK |
| Amount | £1,530,000 (GBP) |
| Funding ID | G0900962 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | Medical Research Council (MRC)-Centre Grant: MRC UoE Centre for Inflammation Research |
| Amount | £1,510,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | Medical Research Council (MRC)-Characterisation and culture of neuromesodermal stem cells |
| Amount | £650,000 (GBP) |
| Funding ID | G0802097 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Medical Research Council (MRC)-Clinical Training Fellowship for Mike Williams: Defining the functional role of the progenitor cell-laminin interaction during liver regeneration |
| Amount | £290,000 (GBP) |
| Funding ID | G0900446 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | Medical Research Council (MRC)-Development of Retinal Transplantation as an Animal Model to Test Stem Cell Therapies for Myelin Diseases |
| Amount | £330,000 (GBP) |
| Funding ID | G0802545 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Medical Research Council (MRC)-Development of a non-invasive strategy enhancing haematopoietic stem cell (HSC) potential of human umbilical cord cells |
| Amount | £870,000 (GBP) |
| Funding ID | G0901577 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2013 |
| Description | Medical Research Council (MRC)-Strategic Appointment of Dr Nerlov |
| Amount | £620,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Medical Research Council (MRC)-Transcriptional regulation of hematopoietic self-renewal, lineage specification and leukemogenesis |
| Amount | £2,100,000 (GBP) |
| Funding ID | G0900892 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | Medical Research Council (MRC)-Transfer of Millstein Award from the University of Cambri |
| Amount | £190,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 05/2012 |
| Description | Motor Neurone Disease Association-Modelling motor neuron disease using induced pluripotential stem cells. |
| Amount | £800,000 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2010 |
| End | 08/2013 |
| Description | Multiple Sclerosis Society-Autologous adult human mesenchymal stem cells: a neuroprotective therapy for MS - supplement |
| Amount | £49,000 (GBP) |
| Organisation | Multiple Sclerosis Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | Multiple Sclerosis Society-Identification of Inflammatory Cytokines that Promote Myelination and Remyelination |
| Amount | £410,000 (GBP) |
| Funding ID | 891 |
| Organisation | Multiple Sclerosis Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | NIH Program Project Grant PO1/NIH |
| Amount | £1 (GBP) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 05/2009 |
| End | 04/2012 |
| Description | NIH Programme Project-Mechanisms Controlling Thymic Homeostasis, Involution, and Rebound.(co applicant potion given)/NIH Programme Project |
| Amount | £32,000 (GBP) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Notch signalling in developmental specification of haematopoietic stem cells |
| Amount | £490,000 (GBP) |
| Organisation | Melville Trust for Care and Cure of Cancer |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Ontogeny of haematopoietic stem cells |
| Amount | £1 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Optistem - Optimization of Stem Cell therapy for clinical trials degenerative skin and muscle disease (12m euros across 18 participants) |
| Amount | £1,100,000 (GBP) |
| Funding ID | 223098 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2009 |
| End | 12/2013 |
| Description | Parkinson's Disease UK-Generation of induced pluripotent stem cells from people with Parkinson's disease. |
| Amount | £370,000 (GBP) |
| Funding ID | H-1002 |
| Organisation | Parkinson's UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Parkinson's Disease UK-Role of FGF signalling in maintenance and differentiation of human pluripotent cells. |
| Amount | £31,500 (GBP) |
| Organisation | Parkinson's UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Pfizer Ltd-Neural induction of mouse and embryonic stem cells - studentship Agnieszka Paca |
| Amount | £25,500 (GBP) |
| Organisation | Pfizer Ltd |
| Sector | Private |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | RCUK Fellowship |
| Amount | £1 (GBP) |
| Organisation | Research Councils UK (RCUK) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Role fo AML1/Runx1 isoforms in development |
| Amount | £1 (GBP) |
| Funding ID | G0500950 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Royal Society/Newton International Fellowship-Pablo Navarro's Newton International Fellowship: Analysis of the gene regulatory network controlling ES cell identity |
| Amount | £100,000 (GBP) |
| Organisation | The Royal Society |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Scottish Biomedical Research Trust-Studentship in Biomedical Research/Scottish Biomedical Research Trust |
| Amount | £400 (GBP) |
| Organisation | SB Drug Discovery |
| Sector | Private |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | Scottish Biomedical Research Trust-Studentship in Biomedical Research/Scottish Biomedical Turst |
| Amount | £3,000 (GBP) |
| Organisation | SB Drug Discovery |
| Sector | Private |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Scottish Executive Pilot Study |
| Amount | £1 (GBP) |
| Organisation | Government of Scotland |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | Scottish Motor Neurone Disease Association-Scottish MND register - a prospective and collaborative platform for improved care, prognostic modelling, research and clinical trials./Scottish Motor Neurone Disease Association |
| Amount | £199,000 (GBP) |
| Organisation | MND Scotland |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | Scottish National Blood Transfusion Service-Proof of principle: human embryonic stem cell derived red cell concentrates for clinical transfusion/Scottish National Blood Transfusion Service |
| Amount | £340,000 (GBP) |
| Organisation | NHS National Services Scotland (NSS) |
| Department | Scottish National Blood Transfusion Service |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2013 |
| Description | Sir Jules Thorn Trust Award (£1.1M National reseach competition), 2007 |
| Amount | £1,100,000 (GBP) |
| Organisation | Sir Jules Thorn Charitable Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2007 |
| End | 04/2010 |
| Description | Stem Cell Research Foundation (USA) |
| Amount | £1 (GBP) |
| Organisation | Bedford Stem Cell Research Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 05/2009 |
| End | 04/2012 |
| Description | The Order of Malta "France"-Insights from m. Leprae-induced early demyelination: towards predictive and therapeutic targets for leprosy nerve damage/The Order of Malta "France" |
| Amount | £29,000 (GBP) |
| Organisation | Order of Malta |
| Department | French Association of the Order of Malta |
| Sector | Public |
| Country | France |
| Start | 05/2010 |
| End | 04/2013 |
| Description | University College London-Comparing and contrasting the gene expression phenotype of dopamine neurons derived from stem cells with that from the human substantia nigra/University College London |
| Amount | £10,000 (GBP) |
| Organisation | University College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | University of Cambridge-Transfer of Funds - David Hampton/University of Cambridge |
| Amount | £72,000 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2013 |
| Description | University of Cambridge-Transfer of MRC Award from Cambridge: Integrin Engineering to Promote Axon Regeneration and Schwann Cell Migration/University of Cambridge |
| Amount | £410,000 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | University of Cambridge-Transfer of MS Society Grant from Cambridge: Costs for A Jarjour/University of Cambridge |
| Amount | £220,000 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | University of Cambridge-Transfer of MS Society Grant from Cambridge: Costs for A Jarjour/University of Cambridge |
| Amount | £72,000 (GBP) |
| Organisation | Multiple Sclerosis Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | University of Georgia-Mechanisms controlling theymic homeostasis, involution and rebound. Core Grant/University of Georgia |
| Amount | £15,000 (GBP) |
| Organisation | University of Georgia |
| Sector | Academic/University |
| Country | United States |
| Start | 09/2010 |
| End | 08/2013 |
| Description | University of Georgia-Mechanisms controlling theymic homeostasis, involution and rebound. Core Grant/University of Georgia |
| Amount | £31,000 (GBP) |
| Organisation | University of Georgia |
| Sector | Academic/University |
| Country | United States |
| Start | 05/2009 |
| End | 04/2012 |
| Description | VIP Award |
| Amount | £1 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | WT Society Award |
| Amount | £1 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | WT Studentship |
| Amount | £1 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | WT Studentship |
| Amount | £1 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | WT VIP award |
| Amount | £1 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2010 |
| End | 04/2013 |
| Description | WT Vacation Scholarship |
| Amount | £1 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Wellcome Trust-Advanced FACS equipment for stemcell research |
| Amount | £830,000 (GBP) |
| Funding ID | 087371 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Wellcome Trust-CAT: Morley: Novel Ligands for Fluorescent Imaging of Breast and Ovarian Cancer in Mouse Models (Brunton) |
| Amount | £290,000 (GBP) |
| Funding ID | 094416 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Wellcome Trust-Comparative genomics of the inflammatory response |
| Amount | £270,000 (GBP) |
| Funding ID | 090385 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Wellcome Trust-ECAT - Support for Piloting Virtual and Face to face Catalysts to Enthuse, Recruit and Retain the Most Able Clinical Academic Trainees |
| Amount | £16,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Wellcome Trust-ECAT: Aldridge: The Role of CDK11 - Mediated Autophagy in Tumour Cells and the Impact of Dysregulation on Tumourgenesis (Frame) |
| Amount | £240,000 (GBP) |
| Funding ID | 094414 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2010 |
| End | 08/2013 |
| Description | Wellcome Trust-ECAT: Lucas: Modulation of Inflammatory Cell Apoptosis in Infectious Lung Injury (Rossi) |
| Amount | £225,000 (GBP) |
| Funding ID | 094415 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2013 |
| Description | Wellcome Trust-ECAT: O'Neill: Can Mitotic Kinases be Expolited as Drug Targets in Oseophageal Adenocarcinoma? (Hupp) |
| Amount | £230,000 (GBP) |
| Funding ID | 094417 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2010 |
| End | 08/2013 |
| Description | Wellcome Trust-ECAT: Sokhi: Developmental Genetics Analysis of Post-Axial Transverse Limb Reduction deformity (PATLRD) (FitzPatrick, MRC HGU) |
| Amount | £230,000 (GBP) |
| Funding ID | 094418 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2010 |
| End | 08/2013 |
| Description | Wellcome Trust-Structural and functional changes in the distal convoluted tubules of the kidney in mouse models of hypertension |
| Amount | £250,000 (GBP) |
| Funding ID | 090387 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Wellcome Trust-The Src and FAK families of non-receptor tyrosine kinases in primary brain tumours |
| Amount | £260,000 (GBP) |
| Funding ID | 090386 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Wellcome Trust-Vacation Scholarship for James Beggs: |
| Amount | £1,500 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Wellcome Trust-Vacation Scholarship for Jayanthi Sethunarayanan: of â-globin expression in HoxB4 overexpressed muring and human embryonic stem |
| Amount | £1,400 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2010 |
| End | 08/2013 |
| Description | Wellcome Trust-Vacation Scholarship for Susanne Maxwell: |
| Amount | £1,500 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Description | Wellcome Trust-WT1 in the kidney: Regulation of the epithelial - mesenchymal balance |
| Amount | £270,000 (GBP) |
| Funding ID | 090388 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2012 |
| Title | DNA vectors |
| Description | DNA vectors |
| Type Of Material | Cell line |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | NK |
| Title | Development of a Fourier domain optical coherence tomography instrument |
| Description | Development of a Fourier domain optical coherence tomography instrument (available at SEE, Used by prof. Davis group, Prof. Tabrizian group) |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | available at SEE, Used by prof. Davis group, Prof. Tabrizian group |
| Title | Development of optical coherence phase microscope |
| Description | Development of optical coherence phase microscope (available at SEE) |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | available at SEE, |
| Title | Gene targeted Human ES cell reporter lines (OC-4, SOX-2, KLF-4) |
| Description | Gene targeted Human ES cell reporter lines (OC-4, SOX-2, KLF-4) provided to Sheffield (Peter Andrews) and Cambridge (Austin Smith) as part of ESTOOLS Consortium Project. |
| Type Of Material | Cell line |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | provided to Sheffield (Peter Andrews) and Cambridge (Austin Smith) |
| Title | IHMED MS database |
| Description | Involved in setting up of the IHMED MS database for both research and clinical care of MS patients. |
| Type Of Material | Database/Collection of Data/Biological Samples |
| Provided To Others? | No |
| Impact | nk |
| Title | Methods for label-free real-time monitoring of stem cell differentiation with electric-cell impedance sensing |
| Description | Methods for label-free real-time monitoring of stem cell differentiation with electric-cell impedance sensing (available in the centre, provided to Paul de Sousa Group, Dr Hay group) |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | available in the centre, provided to Paul de Sousa Group, Dr Hay group |
| Title | Microarray gene expression profile of inflammation in retina |
| Description | Microarray gene expression profile of inflammation in retina, provided to myelin biology consortium based in San Francisco, part of submitted manuscript |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | provided to myelin biology consortium based in San Francisco, part of submitted manuscript |
| Title | Myelinating co-culture systems to analyse effects of signalling molecules on myelination |
| Description | Myelinating co-culture systems to analyse effects of signalling molecules on myelination, have trained visiting scientists from Holland and Portugal, essential part of work in Nature Neuroscience |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | have trained visiting scientists from Holland and Portugal, essential part of work in Nature Neuroscience |
| Title | Non-viral iPSC lines |
| Description | mouse iPS cell lines, generated via pCAG2LMKOSimO |
| Type Of Material | Cell line |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | ecause reprogramming factors(Oct4, Sox2, Klf4 and c-Myc) had been excised from the iPSC lines using Cre-recombinase, we do not need to worry about influence of exogenous factors which remain in iPSCs generated with retroviral vectors. |
| Title | Novel ex vivo HSC generation system |
| Description | We developed a culture system of embryonic AGM region cells which after reaggregation resume generation of the HSC development. This enables analysis of of individual cell populations in HSC development to be performed. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Provided To Others? | No |
| Impact | Elucidating the mechanisms underlying HSC specification and expansion in the embryo have been hampered by the lack of analytical cell culture systems that recapitulate in vivo development. We developed a novel ex vivo model that facilitates a rapid and robust emergence of multipotent longterm repopulating HSCs in the embryonic AGM region and enables analysis of individual cell populations involved in this process to be performed. Using this model, we established the identity of preHSCs which mature into definitive HSCs. The importance of this study is dual i) it will shed light on one of the central problems of HSC biology, namely, genetic regulation of early HSC development and ii) provide mechanistic data for potential development of clinically relevant protocols aiming to enhance production of haematopoietic progenitors and stem cells in vitro. |
| Title | Remyelinating CNS slice culture system |
| Description | Remyelinating CNS slice culture system. Semi-automated system to study and measure remyelination in CNS ex vivo cultures. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | Paper submitted to the journal "Brain". Method taught to lab in Glasgow. Interest from company called Vaccinex, in the US. |
| Title | Runx1 reversible knockout/ reporter mouse |
| Description | A multifunctional reversible knockout/ reporter system enabling fully functional reconstitution of the AML1/Runx1 locus and rescue of haematopoiesis |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Analysis of these mice was an important tool used in publication: N. Stifaniet al(2008) "Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1. Proc Natl Acad Sci USA 105, No 17, 64516456 |
| Title | Tetracyclineinducible Runx1 (short and long isoform) transgenic mice |
| Description | These transgenic mice allow upregulation of short and long Runx1 isoforms in mice |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2007 |
| Provided To Others? | Yes |
| Impact | These mice were analysed by our collaborators which resulted in publication: Aldskogius, et al . "Regulation of Boundary Cap Neural Crest Stem Cell Differentiation after Transplantation" Stem Cells 27, 15921603 |
| Title | pCAF2LMKOSimO |
| Description | a single non-viral reprogramming vector, encoding c-Myc, Klf4, Oct4, Sox2 and mOrange |
| Type Of Material | Cell line |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | It allowed the generation of induced pluripotent stem cells without viral vectors |
| Title | purification of transcription factors |
| Description | the method for purification of transcription factors developed in collaboration with R.Poot and detailed in paper van den Berg, D.L.C., Snoek, T., Mullin, N.P., Yates, A., Bezstarosti, K., Demmers, J. Chambers, I. and Poot, R.A. (2010) An Oct4-centred protein interaction network in embryonic stem cells. Cell Stem Cell, 6, 369-381. is a major advance in the field and we expect this to be widely taken up. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | Expectation that this will be widely taken up |
| Description | AM Collaboration with NIMR |
| Organisation | Medical Research Council (MRC) |
| Department | MRC National Institute for Medical Research (NIMR) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | NK |
| Collaborator Contribution | Research output |
| Impact | NK |
| Description | AM Collaboration with Uppsala |
| Organisation | Uppsala University |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | NK |
| Impact | NK |
| Start Year | 2007 |
| Description | AM collaboration with McGill University |
| Organisation | McGill University |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | NK |
| Collaborator Contribution | Research output |
| Impact | NK |
| Description | AS Collaboration with MRC MHU |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Molecular Haematology Unit |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | NK |
| Collaborator Contribution | Research output |
| Impact | NK |
| Description | Analysis of use of alternative promoters for Runx1 |
| Organisation | University of Oxford |
| Department | Oxford Stem Cell Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provided our Runx1 reactivatable knockout mouse model to Dr Marella de Bruijn |
| Collaborator Contribution | Use of different Runx1 promoters is related to production of short and long Runx1 isoforms |
| Impact | This collaboration resulted in publication: T. Bee, et al. (2009). Alternative Runx1 promoter usage in mouse developmental hematopoiesis. Blood Cells Mol. Dis. 43, 3542 |
| Start Year | 2007 |
| Description | Bernard Roelen (Utrecht)-Investigation of Nanog expression in testes. |
| Organisation | Utrecht University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Investigation of Nanog expression in testes. Supported by funding from WT. |
| Collaborator Contribution | Research output |
| Impact | Kuijk, E.W., de Gier, J., Chuva de Sousa Lopes, S.M., Chambers, I., van Pelt, A.M.M., Colenbrander, B., Roelen, B.A.J. (2010) A distinct pattern in mammalian testes indicates a conserved role for Nanog in spermatogenesis. PloS One, 5, e10987. |
| Start Year | 2009 |
| Description | CB Collaboration with Erasmus Rotterdam |
| Organisation | Erasmus University Rotterdam |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | NK |
| Impact | NK |
| Description | CB Collaboration with Hull/York |
| Organisation | Hull York Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NK |
| Impact | NK |
| Start Year | 2007 |
| Description | CB Collaboration with ISCR Edinburgh |
| Organisation | University of Edinburgh |
| Department | Institute of Stem Cell Research Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NK |
| Collaborator Contribution | Research output |
| Impact | NK |
| Description | CB Collaboration with MD Anderson Cancer Centre |
| Organisation | University of Texas |
| Department | M. D. Anderson Cancer Center |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Development of joint research project. Participation in closed symposia for award holders. |
| Collaborator Contribution | Development of joint research project. |
| Impact | NK |
| Start Year | 2006 |
| Description | CB Collaboration with NIMR |
| Organisation | Medical Research Council (MRC) |
| Department | MRC National Institute for Medical Research (NIMR) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | NK |
| Impact | NK |
| Start Year | 2007 |
| Description | CB Collaboration with Stem Cell Sciences |
| Organisation | Babraham Institute |
| Department | Stem Cell Sciences UK Ltd |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | BBSRC CASE studentship (entered under further funding) |
| Impact | NK |
| Description | CCBS, University of Edinburgh -Second supervisor to PhD student, . Funding from CCBS. |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Second supervisor to PhD student, . Funding from CCBS. |
| Collaborator Contribution | Research output |
| Impact | paper in "Multiple Sclerosis" |
| Start Year | 2009 |
| Description | CIR, University of Edinburgh -Shared PhD student on Tregs in CNS remyelinations, with PhD studentship from the SCRM. |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Shared PhD student on Tregs in CNS remyelinations, with PhD studentship from the SCRM. |
| Collaborator Contribution | Research output |
| Impact | NK |
| Start Year | 2010 |
| Description | CNR, University of Edinburgh-Shared PhD student on the "MS zebrafish", funded by the CCBS. |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Shared PhD student on the "MS zebrafish", funded by the CCBS. |
| Collaborator Contribution | Research output |
| Impact | NK |
| Start Year | 2010 |
| Description | Cambridge University-Biology of Nanog. |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Biology of Nanog. Supported by funding from WT. |
| Collaborator Contribution | Research output |
| Impact | Silva, J., Nichols, J., Theunissen, T.W., Guo, G., van Oosten, A.L., Barrandon, O., Wray, J., Yamanaka, S., Chambers, I. and Smith, A. (2009) Nanog is the gateway to the pluripotent ground state. Cell 138, 722-737. |
| Description | Cellartis-Petter Bjorquist |
| Organisation | Cellartis AB |
| Country | Sweden |
| Sector | Private |
| PI Contribution | Petter Bjorquist |
| Collaborator Contribution | research output |
| Impact | Work in progress |
| Start Year | 2010 |
| Description | Daphne Jackson Fellowship-Joanna Brzeszczynska (2010-2012) sponsored by the Leverhulme Trust. Role of miRNAs in muscle pathophysiology. |
| Organisation | University of Surrey |
| Department | Daphne Jackson Trust |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Joanna Brzeszczynska (2010-2012) sponsored by the Leverhulme Trust. Role of miRNAs in muscle pathophysiology. |
| Collaborator Contribution | Research output |
| Impact | NK |
| Start Year | 2010 |
| Description | Development of AGM reaggregation system |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Developed a new powerful analytical system enabling generation of HSCs ex vivo |
| Collaborator Contribution | Novel protocol for thymus reaggregation technique was provided to us which further refined by us resulted in development of a new powerful ex vivo HSC expansion analytical system |
| Impact | Two publications in prestigeous Cell Stem Cell magazine and Genesis: 1. S. Taoudi et al. (2008) Extensive hematopoietic stem cell (HSC) generation in the AGM region via maturation of VEcadherin+ CD45+ predefinitive HSCs. Cell Stem Cell 3, 99108 2. J. Sheridan et al., "A novel method for the generation of reaggregated organotypic cultures that permits juxtaposition of defined cell populations" Genesis 47, 34651 |
| Start Year | 2006 |
| Description | EU FP6 Consortium Project 'ESTOOLS' -'Recombination Tools and Genetic Switches' |
| Organisation | European Commission |
| Department | EC FP6 Collaborative Projects |
| Country | European Union (EU) |
| Sector | Academic/University |
| PI Contribution | Human ES Cell Genetic Manipulation - 'Recombination Tools and Genetic Switches'. EU involving collaborations with groups in Bonn (Frank Edenhofer), Dresden (Konstantinos Anastassiadis), Sheffield (Peter Andrews). Entirely EU funded but involved expertise and participation FP6 Consortium Project 'ESTOOLS' [August 2006 - August 2010] of MRC Centre Human ES Cell Facility Manager (Judy Flertcher) for work done in Edinburgh University. |
| Collaborator Contribution | Research output |
| Impact | NK |
| Start Year | 2006 |
| Description | Erasmus, Rotterdam-Investigation of protein-protein interactions in pluripotent cells. |
| Organisation | Erasmus University Rotterdam |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Begun approximately 2005. Investigation of protein-protein interactions in pluripotent cells. Supported by funding from WT. |
| Collaborator Contribution | Research output |
| Impact | van den Berg, D.L.C., Zhang, W., Yates, A., Engelen, E., Takacs, K., Bezstarosti, K., Demmers, J. Chambers, I. and Poot, R.A. (2008) The Estrogen Related Receptor Beta interacts with Oct4 to positively regulate Nanog gene expression. Mol. Cell. Biol., 28, 5986-5995 & van den Berg, D.L.C., Snoek, T., Mullin, N.P., Yates, A., Bezstarosti, K., Demmers, J. Chambers, I. and Poot, R.A. (2010) An Oct4-centred protein interaction network in embryonic stem cells. Cell Stem Cell, 6, 369-381. |
| Description | Further development of proteomic and molecular markers of muscle loss. |
| Organisation | Novartis |
| Country | Global |
| Sector | Private |
| PI Contribution | further development of proteomic and molecular markers of muscle loss. |
| Collaborator Contribution | Research output |
| Impact | Contract under discussion |
| Start Year | 2010 |
| Description | Generating models of hepatic endoderm from hESCs suitable for industrial application |
| Organisation | Stem Cells for Safer Medicines (SC4SM) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Collaboration with Josh Brickman in generating models of hepatic endoderm from hESCs suitable for industrial application |
| Collaborator Contribution | Collaboration in generating models of hepatic endoderm from hESCs suitable for industrial application |
| Impact | Grant awarded 2009 £180k - Stem Cells for Safer Medicine |
| Start Year | 2008 |
| Description | Generating models of nutritional programming |
| Organisation | University of Nottingham |
| Department | School of Clinical Sciences Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with Lorraine Young generating models of nutritional programming |
| Collaborator Contribution | Collaboration in generating models of nutritional programming |
| Impact | BBSRC grant awarded 2009 £1.3m |
| Start Year | 2009 |
| Description | Hellmholtz, Munich-Live cell imaging analysis of pluripotent cells. |
| Organisation | Helmholtz Association of German Research Centres |
| Department | Helmholtz Centre for Infection Research (HZI) |
| Country | Germany |
| Sector | Public |
| PI Contribution | Live cell imaging analysis of pluripotent cells. Supported by funding from HFSP. |
| Collaborator Contribution | Research output |
| Impact | Grant funded; 2010-2013 HFSP Programme grant (IC, lead PI) "A microfluidic, small molecule approach to perturbation of the pluripotency transcription network." I.Chambers, T.Schroeder, T.Wandless & L.Lee. $1,200,000 US |
| Start Year | 2010 |
| Description | IRME, Paris, France -Catherine Lubetzki, IRME, Paris, France - started 2006. |
| Organisation | Institute for Research on the Spinal Cord and Brain (IRME) |
| Country | France |
| Sector | Public |
| PI Contribution | Catherine Lubetzki, IRME, Paris, France - started 2006. |
| Collaborator Contribution | Research output |
| Impact | Paper under review at the journal "Brain." |
| Start Year | 2006 |
| Description | IRME, Paris, France-Paper accepted in Annals of Neurology. |
| Organisation | Institute for Research on the Spinal Cord and Brain (IRME) |
| Country | France |
| Sector | Public |
| PI Contribution | Paper accepted in Annals of Neurology. |
| Collaborator Contribution | Research output |
| Impact | Paper accepted in Annals of Neurology. |
| Start Year | 2008 |
| Description | Ian Wark institute, Adelaide, Australia-Assessing nanoparticles cytotoxicity on stem cells with impedance sensing. |
| Organisation | University of South Australia |
| Department | Ian Wark Institute |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Ongoing: Assessing nanoparticles cytotoxicity on stem cells with impedance sensing. |
| Collaborator Contribution | Research output |
| Impact | Work presented at Biosensors 2010, Glagow. Manuscript in preparation. |
| Start Year | 2010 |
| Description | Institut Pasteur, Paris-Investigation of pluripotency factor function in epigenetic mechanisms of X-inactivation. |
| Organisation | Pasteur Institute, Paris |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Begun approximately 2005. Investigation of pluripotency factor function in epigenetic mechanisms of X-inactivation. Supported by funding from WT & EuroSyStem. |
| Collaborator Contribution | Research output |
| Impact | Navarro, P., Chambers, I., Karwacki-Neisius, V., Chureau, C., Morey, C., Rougelle, C. and Avner, P. (2008) Direct molecular coupling of Xist regulation and pluripotency. Science, 321, 1693-1695 Cited in Faculty of 1000: http://www.f1000biology.com/article/id/1124285/evaluation & Navarro, P., Oldfield, A., Legoupi, J., Festuccia, N., Dubois, A., Attia, M., Rougeulle, C., Chambers, I. and Avner, P. Molecular coupling of Tsix regulation and pluripotency. Accepted at Nature. |
| Description | Jacqueline Deschamps- Cdx2 and axial progenitors. |
| Organisation | Royal Netherlands Academy of Arts and Sciences |
| Department | Hubrecht Institute |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Collaboration with Jacqueline Deschamps on Cdx2 and axial progenitors. Started 2006, Funded by BBSRC and MRC. |
| Collaborator Contribution | Research output |
| Impact | paper in Dev Biol 2010. |
| Start Year | 2006 |
| Description | Jean-François Nicolas and Elena Tzouanacou -clonal lineage analysis, |
| Organisation | Pasteur Institute, Paris |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Collaboration with Jean-Francois Nicolas and Elena Tzouanacou on clonal lineage analysis, Funded by FPV network Eurostemcell and BBSRC |
| Collaborator Contribution | Research output |
| Impact | paper in Dev Cell 2009. |
| Start Year | 2009 |
| Description | Lamellar Biomedical Ltd.-Consultancy, progress toward clinical trials, treatment for secretory disorders. |
| Organisation | Lamellar Biomedical Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Consultancy, progress toward clinical trials, treatment for secretory disorders. |
| Collaborator Contribution | CSO bid being asembled |
| Impact | CSO bid being asembled |
| Start Year | 2009 |
| Description | Leicester-analysis of cytoskeletal function in myelination, |
| Organisation | University of Leicester |
| Department | Department of Molecular and Cell Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | David Critchley (Leicester), analysis of cytoskeletal function in myelination, 2008, work ongoing |
| Collaborator Contribution | Research output |
| Impact | NK |
| Start Year | 2008 |
| Description | Life Technologies-Joydeep Guswami |
| Organisation | Life Technologies |
| Country | Global |
| Sector | Private |
| PI Contribution | Joydeep Guswami |
| Collaborator Contribution | Research output |
| Impact | Work in progress |
| Start Year | 2010 |
| Description | MRC -Development of multi-modal contrast agents for imaging and gene delivery, funding from BHF and Wellcome Trust - Carmel Moran, Keith Fox, Dave Newby, Ian Marshall, John Mullins, etc (UoE), 2005,2008. |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of multi-modal contrast agents for imaging and gene delivery, funding from BHF and Wellcome Trust - Carmel Moran, Keith Fox, Dave Newby, Ian Marshall, John Mullins, etc (UoE), 2005,2008. |
| Collaborator Contribution | Research output |
| Impact | NK |
| Description | MRC funded A genetic approach to develop novel mouse models of liver disease |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Characterisation of disease models |
| Collaborator Contribution | Several mouse models of liver disease have been established and are now being validated |
| Impact | Mouse models will be made available to the community once validation is complete |
| Start Year | 2008 |
| Description | MRC funded project to enhance axon regeneration in spinal cord injury. |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | MRC funded project to enhance axon regeneration in spinal cord injury. With Fawcett (Cambridge) Co-PI responsible for integrin engineering |
| Collaborator Contribution | MRC funded project to enhance axon regeneration in spinal cord injury. Co-PI responsible for integrin engineering |
| Impact | J Neurosci paper in 2009 |
| Start Year | 2008 |
| Description | MRC-Differentiation of hepatocytes from hES and hiPS cells Dave Hay (CRM) and Gareth Sullivan & Ian Wilmut (CRM), |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Differentiation of hepatocytes from hES and hiPS cells Dave Hay (CRM) and Gareth Sullivan & Ian Wilmut (CRM), |
| Collaborator Contribution | several publications |
| Impact | NK |
| Start Year | 2009 |
| Description | MRC-Exocytosis in hepatocytes - Rory Duncan, Centre for Integrative Physiology, UoE |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Exocytosis in hepatocytes - Rory Duncan, Centre for Integrative Physiology, UoE |
| Collaborator Contribution | Research output |
| Impact | NK |
| Start Year | 2009 |
| Description | MRC-Heparan sulfate in human liver and pancreas development, Cathy Merry, University of Manchester, 2010 |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Heparan sulfate in human liver and pancreas development, Cathy Merry, University of Manchester, 2010 |
| Collaborator Contribution | Research output |
| Impact | preliminary work underway |
| Start Year | 2010 |
| Description | MRC-MRC clinical training fellowship (2008) for Janet Kung [CRM liver grouping]. co-supervisors Stuart Forbes (CRM) & Paddy Hadoke (CVS) |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | MRC clinical training fellowship (2008) for Janet Kung [CRM liver grouping]. co-supervisors Stuart Forbes (CRM) & Paddy Hadoke (CVS) |
| Collaborator Contribution | Research output |
| Impact | NK |
| Start Year | 2009 |
| Description | MRC-MRC clinical training fellowship (2010) for Robert Drummond on pancreas development - P Shiels, University of Glasgow (co-supervisor), Kevin Docherty (collaborator), University of Aberdeen. [CRM liver grouping & external collaborators]. |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | MRC clinical training fellowship (2010) for Robert Drummond on pancreas development - P Shiels, University of Glasgow (co-supervisor), Kevin Docherty (collaborator), University of Aberdeen. [CRM liver grouping & external collaborators]. |
| Collaborator Contribution | Research support |
| Impact | NK |
| Start Year | 2009 |
| Description | MRC-Tissue scaffolds - Richard Black, University of Strathclyde |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Tissue scaffolds - Richard Black, University of Strathclyde |
| Impact | application in progress |
| Start Year | 2009 |
| Description | MRc-iPS creation and stem cell differentiation via small molecules - Dave Adams, Heriot-Watt, |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | iPS creation and stem cell differentiation via small molecules - Dave Adams, Heriot-Watt, |
| Collaborator Contribution | Research output |
| Impact | Prelimary work underway |
| Start Year | 2009 |
| Description | McGill, Montreal, Canada-Assessing stem cell viability in 3D scaffold with FDOCT. |
| Organisation | McGill University |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Ongoing: 6 Months Ph. D. student exchange, 2010 and 2011. Assessing stem cell viability in 3D scaffold with FDOCT. |
| Collaborator Contribution | Research output |
| Impact | Work accepted for Photonics West, BIOS 2011, San Francisco, manuscript published in JBO (2011) Work to be presented at FSB 2012. 1st PhD visit: 2011 2nd PhD Visit from January to March 2012 |
| Start Year | 2009 |
| Description | Melbourne-analysis of Scribble function in meylination, |
| Organisation | Peter MacCallum Cancer Centre |
| Country | Australia |
| Sector | Hospitals |
| PI Contribution | Patrick Humbert (Melbourne) analysis of Scribble function in meylination, work ongoing |
| Collaborator Contribution | Research output |
| Impact | Work ongoing |
| Start Year | 2010 |
| Description | Milan_ analysis of neuregulin function in myelination |
| Organisation | San Raffaele del Monte Tabor Foundation |
| Country | Italy |
| Sector | Hospitals |
| PI Contribution | Carla Taveggia (Milan) analysis of neuregulin function in myelination, 2008, |
| Collaborator Contribution | research output |
| Impact | paper in preparation |
| Start Year | 2008 |
| Description | Multicell Technologies-Maertin Schroeder |
| Organisation | Multicell Technologies |
| Country | United States |
| Sector | Private |
| PI Contribution | Maertin Schroeder |
| Collaborator Contribution | Research output |
| Impact | Work in progress |
| Start Year | 2010 |
| Description | NIH funded Quantum project to develop artifical niches for stroke repair |
| Organisation | National Institutes of Health (NIH) |
| Country | United States |
| Sector | Public |
| PI Contribution | NIH funded Quantum project to develop artifical niches for stroke repair With Hirschi/Dickinson/Brenner/Rice (Baylor), Price/Modo (Kings), Lovell-Badge (NIMR) Co-PI responsible for Mapping CNS stem cell niche in normal adult and following injury |
| Collaborator Contribution | Collaborated on NIH funded Quantum project to develop artifical niches for stroke repair. Co-PI responsible for Mapping CNS stem cell niche in normal adult and following injury |
| Impact | Paper submitted to Stem Cells |
| Start Year | 2006 |
| Description | National Multiple Sclerosis Society funded translational research project funded under Promise 2010 initiative. |
| Organisation | Multiple Sclerosis Society |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | National Multiple Sclerosis Society funded translational research project funded under Promise 2010 initiative. With Franklin (Cambridge), Baron (Paris), Martino (Milan), Rowitch (UCSF), Goldman (Rochester), Antel (Montreal), Weiss (Calgary). Lead PI responsible for project coordination and identification of new targets for remyelination. |
| Collaborator Contribution | National Multiple Sclerosis Society funded translational research project funded under Promise 2010 initiative. Lead PI responsible for project coordination and identification of new targets for remyelination. |
| Impact | 2 papers in 2009 - JCB, J Neurosci. |
| Description | Primorigen -Chuck Ohler |
| Organisation | Primorigen Biosciences |
| Country | United States |
| Sector | Private |
| PI Contribution | Chuck Ohler |
| Collaborator Contribution | Research output |
| Impact | Work in progress |
| Start Year | 2010 |
| Description | Role of Runx1 in differentiation of doundary cap neural crest stem cell differentiation |
| Organisation | Uppsala University |
| Department | Department of Neuroscience |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Provided Runx1 (short and long isoforms) inducible constructs and transgenic mice |
| Collaborator Contribution | We learned how our Runx1 tetracyclineinducible constructs work in primary cells |
| Impact | Publication in prestigeous stem cell magazine: Aldskogius, et al., "Regulation of Boundary Cap Neural Crest Stem Cell Differentiation after Transplantation" Stem Cells 27, 15921603 |
| Start Year | 2007 |
| Description | Role of Runx1 in neural development |
| Organisation | McGill University |
| Department | Montreal Neurological Institute and Hospital |
| Country | Canada |
| Sector | Hospitals |
| PI Contribution | We provided our Runx1 reactivatable knockout mouse model to Prof. S. Stifani |
| Collaborator Contribution | We learned about the role of Runx1 in neural development which may have parallels with haematopoietic development and performed complex genotyping of compound transgenic embryos |
| Impact | Publication in prestigeous scientific magazine PNAS: N. Stifani et al. (2008) "Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1. Proc Natl Acad Sci USA 105, No 17, 64516456 |
| Start Year | 2006 |
| Description | Single vector reprogramming system |
| Organisation | Mount Sinai Hospital (Canada) |
| Department | Samuel Lunenfeld Research Institute |
| Country | Canada |
| Sector | Hospitals |
| PI Contribution | We developed a system with which we can generate non-genetically modified induced pluripotent stem cells |
| Collaborator Contribution | By combining their piggyBac system and our single vector system we developped a system with which we can generate non-genetically modified induced pluripotent stem cells. |
| Impact | Using the system we published two Nature papers. |
| Start Year | 2008 |
| Description | Stanford-Using destabilising domain fusions to probe protein function in pluripotent cells. |
| Organisation | Stanford University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Using destabilising domain fusions to probe protein function in pluripotent cells. Supported by funding from WT & HFSP. |
| Collaborator Contribution | Research output |
| Impact | Grant funded; 2010-2013 HFSP Programme grant (IC, lead PI) "A microfluidic, small molecule approach to perturbation of the pluripotency transcription network." I.Chambers, T.Schroeder, T.Wandless & L.Lee. $1,200,000 US |
| Start Year | 2007 |
| Description | Stem Cell Technologies-George White |
| Organisation | Stem Cell Technologies |
| Country | Canada |
| Sector | Private |
| PI Contribution | George White |
| Collaborator Contribution | Research output |
| Impact | Work in progress |
| Start Year | 2010 |
| Description | Studying transplantation of hESC-derived hepatic endoderm into animal models |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with Philip Newsome and David Adams in studying transplantation of hESC-derived hepatic endoderm into animal models |
| Collaborator Contribution | Collaboration in studying transplantation of hESC-derived hepatic endoderm into animal models |
| Impact | MRC Grant awarded (£500k) |
| Start Year | 2008 |
| Description | Syntaxin-basis for exocytosis blocking project in 2010, treatment for secretory disorders |
| Organisation | Syntaxin |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | basis for exocytosis blocking project in 2010, treatment for secretory disorders |
| Collaborator Contribution | NK |
| Impact | NK |
| Start Year | 2009 |
| Description | TMRI/Wyeth - completion of translational studies of biomarkers of muscle loss, large cohort study for molecular and proteomic biomarker identification in muscle loss and regeneration (sarcopenia & cancer cachexia), |
| Organisation | Pfizer Ltd |
| Department | Wyeth Pharmaceuticals |
| Country | United States |
| Sector | Private |
| PI Contribution | completion of translational studies of biomarkers of muscle loss, large cohort study for molecular and proteomic biomarker identification in muscle loss and regeneration (sarcopenia & cancer cachexia), |
| Collaborator Contribution | Research output |
| Impact | Publications in progress |
| Start Year | 2009 |
| Description | UC, Berkeley-Bio-engineering applications for the study of pluripotent cells. |
| Organisation | University of California, Berkeley |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Bio-engineering applications for the study of pluripotent cells. Supported by funding from UK FCO & HFSP. |
| Collaborator Contribution | Research output |
| Impact | Grants funded; 2010-2013 HFSP Programme grant (IC, lead PI) "A microfluidic, small molecule approach to perturbation of the pluripotency transcription network." I.Chambers, T.Schroeder, T.Wandless & L.Lee. $1,200,000 US & 2009 Foreign & Commonwealth Office, UK-US Stem Cell Collaboration Development Award. I.Chambers and L. Lee (UC Berkeley) £2,782 |
| Start Year | 2009 |
| Description | UK Multiple Sclerosis Society funded Centre for Repair in Cambridge. |
| Organisation | Multiple Sclerosis Society |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | UK Multiple Sclerosis Society funded Centre for Repair in Cambridge. With Franklin, Compston, Chandran, Fawcett, Spillantini (all Cambridge originally, Chandran now moved to Edinburgh) Co-PI responsible for target discovery based on array profiling remyelination and inflammation |
| Collaborator Contribution | UK Multiple Sclerosis Society funded Centre for Repair in Cambridge. Co-PI responsible for target discovery based on array profiling remyelination and inflammation |
| Impact | Paper submitted to Nature Neurosci (and sent out for review) |
| Start Year | 2006 |
| Description | University College London-Humphrey Hodgson |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Humphrey Hodgson |
| Collaborator Contribution | Research output |
| Impact | Work in progress |
| Start Year | 2010 |
| Description | University of Edinburgh-Analysis of the perdurance of the pluripotent state in vivo and in vitro. |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Analysis of the perdurance of the pluripotent state in vivo and in vitro. Supported by funding from WT and CONACYT (I.C.) and MRC (V.W.). |
| Collaborator Contribution | Research output |
| Impact | Tsakiridis, A., Tzouanacou, E.,Rahman, A., Colby, D., Axton, R., Chambers, I., Wilson, V., Forrester, L. and Brickman, J. (2009) Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells. Nucleic Acids Res. 37, e129. & Osorno, R., Tsakiridis, A., Cambray, N., Economou, C., Wymeersch, F., Wilkie, R., Scotting, P., Chambers, I. and Wilson, V. The developmental extinction of pluripotency is reversed by ectopic Oct4 expression. In preparation for re-submission to Nature. I.C. & V.W. are joint senior authors. |
| Start Year | 2007 |
| Description | University of Edinburgh-Bioinformatic analysis of gene expression and chromatin binding in pluripotent cells. |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Bioinformatic analysis of gene expression and chromatin binding in pluripotent cells. Supported by funding from WT and EuroSyStem. |
| Collaborator Contribution | Researh output |
| Impact | Paper: Chambers, I. and Tomlinson, S. (2009) The transcriptional foundation of pluripotency. Development, 136, 2311-2322, Grant submitted; MRC programme grant application "Transcription factor dynamics in control of pluripotent cell function and identity" (I. Chambers, P.I.) submitted 01/09/10; decision due Feb 2012. |
| Start Year | 2007 |
| Description | University of Edinburgh-Novel gene trap vectors. |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Novel gene trap vectors. Supported by funding from WT. |
| Collaborator Contribution | Research output |
| Impact | Tsakiridis, A., Tzouanacou, E.,Rahman, A., Colby, D., Axton, R., Chambers, I., Wilson, V., Forrester, L. and Brickman, J. (2009) Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells. Nucleic Acids Res. 37, e129. |
| Start Year | 2009 |
| Description | University of Edinburgh-Structure-function investigations of Nanog and partner proteins |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Begun 2005. Structure-function investigations of Nanog and partner proteins. Supported by funding from BBSRC & WT. |
| Collaborator Contribution | Research output |
| Impact | Papers: Mullin, N.P., Yates, A., Rowe, A., Nijmeijer, B. Barlow, P.N., Walkinshaw, M.D. and Chambers, I. (2008) The pluripotency rheostat Nanog functions as a dimer. Biochem. J. , 411, 227-231 Cited in Faculty of 1000: http://f1000biology.com/article/id/1137963/evaluation & van den Berg, D.L.C., Snoek, T., Mullin, N.P., Yates, A., Bezstarosti, K., Demmers, J. Chambers, I. and Poot, R.A. (2010) An Oct4-centred protein interaction network in embryonic stem cells. Cell Stem Cell, 6, 369-381. Grants funded; 2008-2011 Wellcome Trust Project 'Biochemical Interactions of the Pluripotency Rheostat, Nanog'. I. Chambers, (P.I.). M. Walkinshaw & P. Barlow, £267,873 & 2005-2007 BBSRC project 'Structure-function relationship of the novel ES cell transcriptional determinant Nanog'. I. Chambers, (P.I.), M. Walkinshaw & P. Barlow, £359,327. |
| Description | University of Edinburgh-analysing cell adhesion molecules in myelination |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Peter Brophy (Edinburgh), shared Wellcome Trust programme grant analysing cell adhesion molecules in myelination, 2008, work ongoing |
| Collaborator Contribution | Research output |
| Impact | NK |
| Start Year | 2008 |
| Description | University of Edinburgh-analysis of the stem cell response in animal models of schizophrenia and bipolar disorder, |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Andrew McIntosh and David Porteus (Edinburgh), analysis of the stem cell response in animal models of schizophrenia and bipolar disorder, 2009 |
| Collaborator Contribution | Research results |
| Impact | paper submitted to Molecular Psychiatry |
| Start Year | 2009 |
| Description | University of Edinburgh-using zebrafish to examine molecular mechanisms of myelination |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | David Lyons (Edinburgh) using zebrafish to examine molecular mechanisms of myelination, 2009, paper in preparation |
| Collaborator Contribution | Research output |
| Impact | paper in preparation |
| Start Year | 2009 |
| Description | University of Liverpool-Kevin Park |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Kevin Park |
| Collaborator Contribution | Research output |
| Impact | Work in progress |
| Start Year | 2010 |
| Description | Unviersity of Utrecht -Jan Schrickx |
| Organisation | Utrecht University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Jan Schrickx |
| Collaborator Contribution | Research output |
| Impact | Work in progress |
| Start Year | 2010 |
| Description | Use of iPS cells to study ALS |
| Organisation | King's College London |
| Department | Institute of Psychiatry, Psychology & Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Derive iPS cells from patients with inherited cases of ALS along with age and geneder matched controls |
| Collaborator Contribution | Tisse samples from patients and an understanding of the genetics of the disease |
| Impact | Neural populations of different genotype for further detailed study |
| Start Year | 2008 |
| Description | YK Collaboration with Edinburgh |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NK |
| Collaborator Contribution | Research output |
| Impact | NK |
| Description | iPerian-Mike Venuti |
| Organisation | Bristol-Myers Squibb |
| Department | iPerian |
| Country | United States |
| Sector | Private |
| PI Contribution | Mike Venuti |
| Collaborator Contribution | Research output |
| Impact | Work in progress |
| Start Year | 2010 |
| Description | screening polymer libraries using hESC-derived hepatic endoderm |
| Organisation | University of Edinburgh |
| Department | School of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | screening polymer libraries using hESC-derived hepatic endoderm |
| Collaborator Contribution | Collaboration in screening polymer libraries using hESC-derived hepatic endodermProvided library of compoounds |
| Impact | Compounds were identified that provide effective support for human hepatic endoderm |
| Start Year | 2008 |
| Description | screening polymer libraries using hESC-derived hepatic endoderm |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | screening polymer libraries using hESC-derived hepatic endoderm |
| Collaborator Contribution | Collaboration in screening polymer libraries using hESC-derived hepatic endodermProvided library of compoounds |
| Impact | Compounds were identified that provide effective support for human hepatic endoderm |
| Start Year | 2008 |
| Title | Anterior definitive endoderm 11 |
| Description | Anterior definitive endoderm 11 |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Apoptotic bodies for the generation of noval Abs for monoclaonal therapy |
| Description | Apoptotic bodies for the generation of noval Abs for monoclaonal therapy |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | CULTURE MEDIUM CONTAINING KINASE INHIBITORS, AND USES THEREOF |
| Description | Pluripotent cells are maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and, optionally, an antagonist of an FGF receptor. Pluripotent cells are also maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor and an antagonist of an FGF receptor. Also published as EP1999249 |
| IP Reference | US2010041137 |
| Protection | Patent granted |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | Not known |
| Title | Cell Culture Methods to Produce ADE Cells |
| Description | Production of an efficient and effective culture method for purifying intermediate in vitro-derived ADE cells from embryonic stem cells |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | Currently available to companies |
| Title | Cellular therapy to treat cirrhosis of the liver |
| Description | Cellular therapy to treat cirrhosis of the liver |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Control of ES Cell Self Renewal and Lineage Specification, and Medium Therefor |
| Description | Self renewal of pluripotent cells in culture is promoted using a combination of an activator of a signalling pathway downstream of a receptor of the TGF-beta superfamily and an activator of a gp130 downstream signalling pathway. Also published as KR20070030164 |
| IP Reference | JP2008228742 |
| Protection | Patent granted |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | Not known |
| Title | Dextransulphate a novel reagent for stem cell differentiation |
| Description | Dextransulphate a novel reagent for stem cell differentiation |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Disclosure |
| Description | Biodegradable Encapsulates for Affinity Targeted (BEAT) Technology in Stem Cell Culture and Regenerative Medicine |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Disclosure |
| Description | Frzb role in hematopoietic differentiation |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Disclosure |
| Description | Glycocalyx |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Disclosure |
| Description | MRCT (CRB): Anti-mullerian Hormone |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Disclosure |
| Description | Novel Relaxin Mimetic |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Disclosure |
| Description | Retinoid independent and accelerated generation of functional motor neurons from human embryonic stem cells |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Disclosure |
| Description | Transgenic mice for studying the haemotpoetic system |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | ES Cell self renewal factor |
| Description | ES Cell self renewal factor |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Embedded licence in SC4SM contract |
| Description | Embedded licence in SC4SM contract |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Embedded licence: HESC Blood project |
| Description | Embedded licence: HESC Blood project |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Expression of heterologous genes according to a targeted expression profile |
| Description | A gene trap vector comprises a DNA construct containing an expression unit of an internal ribosome binding site (IRES) coupled to a heterologous gene sequence; this expression unit is used in gene trap protocols to obtain expression of the heterologous gene in the host. |
| IP Reference | JP2007306942 |
| Protection | Patent granted |
| Year Protection Granted | 2007 |
| Licensed | No |
| Impact | Not known |
| Title | Glioma-dervided Neuronal Stem Cell Lines for Screening |
| Description | New method of production of glioma neural stem cell lines from tumours |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | Commercial In Confidence |
| Impact | Discussion with commercial companies in progress |
| Title | HA (800 000 D) as hESC substrate supports renewal |
| Description | HA (800 000 D) as hESC substrate supports renewal |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | HUMANISATION OF ANIMALS |
| Description | The present invention relates to the generation of transgenic animal cells and/or animals in which a large portion of a host animal's genome has been replaced with an equivalent syntenic portion of nucleic acid from the genome of a different organism. |
| IP Reference | EP2099289 |
| Protection | Patent granted |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | Not known |
| Title | Hepatocyte differentiation media |
| Description | Hepatocyte differentiation media |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | High throughput method for screening gene target |
| Description | High throughput method for screening gene target |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Human platelet lysates for human cartilage formation |
| Description | Human platelet lysates for human cartilage formation |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Improving options for bone marrow transplants |
| Description | Development of a novel mehof of culture and differentiaation of embryonic stem cells that will enable derivation and exapansion of HSCs in vitro. |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Licence - tech ID 1023 - Andrew Smith |
| Description | Licence - tech ID 1023 - Andrew Smith - Astra Zeneca Non-exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence - tech ID 1023 - Andrew Smith |
| Description | Licence - tech ID 1023 - Andrew Smith - Charles River Laboratories, Inc. Field Exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Licence - tech ID 1023 - Andrew Smith |
| Description | Licence - tech ID 1023 - Andrew Smith - Novartis AG Non-exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence - tech ID 1084 - Josh Brickman |
| Description | Licence - tech ID 1084 - Josh Brickman - Geron Corporation Evaluation |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence - tech ID 2048 - Keisuke Kaji |
| Description | Licence - tech ID 2048 - Keisuke Kaji - Active Motif Non Exclusive April 2010 |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Licence - tech ID 2048 - Keisuke Kaji |
| Description | Licence - tech ID 2048 - Keisuke Kaji - Active Motif Non Exclusive Feb 2010 |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Licence - tech ID 2048 - Keisuke Kaji |
| Description | Licence - tech ID 2048 - Keisuke Kaji - Adgene Non-exlcusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence - tech ID 2048 - Keisuke Kaji |
| Description | Licence - tech ID 2048 - Keisuke Kaji - Hematech Inc Evaluation |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence - tech ID 2048 - Keisuke Kaji |
| Description | Licence - tech ID 2048 - Keisuke Kaji - iPerian, Inc Evaluation |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | NK |
| Title | Licence - tech ID 2119 - Clare Blackburn |
| Description | Licence - tech ID 2119 - Clare Blackburn - Millipore Corporation Non-Exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence - tech ID 2127 - Josh Brickman |
| Description | Licence - tech ID 2127 - Josh Brickman - Stem Cells 4 Safer Medicine Limited Non-Exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence - tech ID 223 & 254 - J A Ross |
| Description | Licence - tech ID 223 & 254 - J A Ross - Millipore Corporation Non-Exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence - tech ID 223 - J A Ross |
| Description | Licence - tech ID 223 - J A Ross - Santa Cruz Non-Exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence - tech ID 2317 - Lesley Forrester |
| Description | Licence - tech ID 2317 - Lesley Forrester - SNBTS Exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence - tech ID 2388 - Brendon Noble |
| Description | Licence - tech ID 2388 - Brendon Noble - Gernon Corporation - Field Exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Licence - tech ID 254 - J A Ross |
| Description | Licence - tech ID 254 - J A Ross - Santa Cruz Non-exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence - tech ID 928 - Keisuke Kaji |
| Description | Licence - tech ID 928 - Keisuke Kaji - European Collection of Cell Cultures - Non-Exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Licence under negotiation - tech ID 1084 - Josh Brickman |
| Description | Licence under negotiation - tech ID 1084 - Josh Brickman - evaluate use to make research reagents with view to take an exclusive licence - Evaluation |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Licence under negotiation - tech ID 2048 - Brendon Noble |
| Description | Licence under negotiation - tech ID 2048 - Brendon Noble - To make therapeutics - Exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Licence under negotiation - tech ID 2048 - Keisuke Kaji |
| Description | Licence under negotiation - tech ID 2048 - Keisuke Kaji - Company requested exclusive licence for research reagents and therapeutics. UoE thinks non-exclusive is more appropriate. Scope of licence and field of use under discussion.- Non-Exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Licence under negotiation - tech ID 2048 - Keisuke Kaji |
| Description | Licence under negotiation - tech ID 2048 - Keisuke Kaji - Evaluation of iPS cell lines- Non-Exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Licence under negotiation - tech ID 2048 - Keisuke Kaji |
| Description | Licence under negotiation - tech ID 2048 - Keisuke Kaji - Stemgent Non-Exclusive Feild of use - Research reagents |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence under negotiation - tech ID 2048 - Keisuke Kaji |
| Description | Licence under negotiation - tech ID 2048 - Keisuke Kaji - to humanise mouse models.- Non-Exclusive |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Licence under negotiation - tech ID 2048 - Keisuke Kaji |
| Description | Licence under negotiation - tech ID 2048 - Keisuke Kaji Active Motif Non-exclusive Field of use - Development of research reagents |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence under negotiation - tech ID 2048 - Keisuke Kaji |
| Description | Licence under negotiation - tech ID 2048 - Keisuke Kaji Mitergy LLC Evaluation licence Field of use - internal evaluation |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence under negotiation - tech ID 2048 - Keisuke Kaji |
| Description | Licence under negotiation - tech ID 2048 - Keisuke Kaji iPerian, Inc Evaluation licence Field of use - internal evaluation |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence under negotiation - tech ID 2198 - Mark Bradley |
| Description | Licence under negotiation - tech ID 2198 - Mark Bradley Stemgent Evaluation licence Field of use - in discussion |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Licence under negotiation - tech ID 2398 - David Hay/John Iredale |
| Description | Licence under negotiation - tech ID 2398 - David Hay/John Iredale - Cellartis AB - Evaluation |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Licence under negotiation - tech ID 2398 - David Hay/John Iredale |
| Description | Licence under negotiation - tech ID 2398 - David Hay/John Iredale - Primorigen Biosciences - Evaluation |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Lineage specific cells and progenitor cells |
| Description | A method for generating a culture that is purified or enriched in respect of cells of a selected lineage is described in which selectable marker, which is differentially expressed in cells of the selected lineage compared with its expression in other cells, is introduced into a multipotential cell and the multipotential cell is cultured to induce differentiation of the multipotential cell into a cell of the selected lineage, or into a mixture of cells including cells of the selected lineage, or is cultured to induce preferential survival of cells of the selected lineage. Those cells that express the selectable marker are then selected for. Progenitors of selected lineage are also described as is the use of the method in assay techniques. |
| IP Reference | US2007264709 |
| Protection | Patent granted |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | None known |
| Title | Lithium Chloride as a novel reagent to promote stem cell differentiation into bone |
| Description | Lithium Chloride as a novel reagent to promote stem cell differentiation into bone |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Method for differentiating stem cells |
| Description | Method for differentiating stem cells |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Novel Polymers for culturing liver cells |
| Description | Identification of a novel polymer which provides a solution to poor quality cells |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | Commercial In Confidence |
| Impact | Discussion with commercial companies in progress |
| Title | Novel method for producing hepatocytes from IPS cells |
| Description | Novel method for producing hepatocytes from IPS cells |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Novel method of hepatocyte differentiation form IPS cells |
| Description | Novel method of hepatocyte differentiation form IPS cells |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Patent - tech ID 1084 - Josh Brickman |
| Description | Patent - tech ID 1084 - Josh Brickman - Endoderm Culture Type PCT |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Patent - tech ID 1084 - Josh Brickman |
| Description | Patent - tech ID 1084 - Josh Brickman - Regionalised endoderm cells and uses thereof - National |
| IP Reference | EP2195417 |
| Protection | Patent granted |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Patent - tech ID 2048 - Keisuke Kaji |
| Description | Patent - tech ID 2048 - Kaji Keisuke - Induced Pluripotent Stem Cells Type - PCT |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Patent - tech ID 2108 - Paul de Sousa |
| Description | Patent - tech ID 2108 - Paul de Sousa - Method for differentiating stem cells Type - National |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Patent - tech ID 2108 - Paul de Sousa |
| Description | Patent - tech ID 2108 - Paul de Sousa - Method for differentiating stem cells Type - PCT |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Patent - tech ID 2108 - Paul de Sousa |
| Description | Patent - tech ID 2108 - Paul de Sousa - Method for differentiating stem cells Type - Priority |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Patent - tech ID 2110 - Paul de Sousa |
| Description | Patent - tech ID 2110 - Paul de Sousa - HA (800 000 D) as hESC substrate supports renenwal Type - Priority |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Patent - tech ID 2110 - Paul de Sousa |
| Description | Patent - tech ID 2110 - Paul de Sousa - HA (800 000 D) as hESC substrate supports renewal Type - PCT |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Patent - tech ID 2198 - Dave Hay/John Iredale |
| Description | Patent - tech ID 2198 - Dave Hay/John Iredale - Polymer for hepatocyte culture - PCT |
| IP Reference | WO2010106345 |
| Protection | Patent granted |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Patent - tech ID 2388 - Brendon Noble |
| Description | Patent - tech ID 2388 - Brendon Noble -Novel method for chondrocyte formation - Priority |
| IP Reference | US2011256109 |
| Protection | Patent granted |
| Year Protection Granted | 2011 |
| Licensed | No |
| Impact | NK |
| Title | Patent - tech ID 490 - Ian Chambers |
| Description | Patent - tech ID 490 - Ian Chambers - Pluripotency determining factors (Nanog) - National |
| IP Reference | WO2003064463 |
| Protection | Patent granted |
| Year Protection Granted | |
| Licensed | No |
| Impact | NK |
| Title | Patent - tech ID 859 - Andrew Smith |
| Description | Patent - tech ID 859 - Andrew Smith - Genome replacement technology Type - National |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Patent - tech ID 859 - Andrew Smith |
| Description | Patent - tech ID 859 - Andrew Smith - Humanisation of Animals - National |
| IP Reference | US20100122361 |
| Protection | Patent granted |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | NK |
| Title | Plet 1 Antibodies |
| Description | Plet 1 Antibodies |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Pluripotent cells from rat and other species |
| Description | Pluripotent cells are derived and maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and an antagonist of an FGF receptor. Also published as EP2049654 |
| IP Reference | US2008066197 |
| Protection | Patent granted |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | Not known |
| Title | Polymers for joint capping |
| Description | Polymers for joint capping |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Primary screen to identify compounds to treat cirrhosis of the liver |
| Description | Primary screen to identify compounds to treat cirrhosis of the liver |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Production of transplantable haematopoietic stem cells |
| Description | Production of transplantable haematopoietic stem cells |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | REPROGRAMMING AND GENETIC MODIFICATION OF CELLS |
| Description | Methods for reprogramming and optional genetic modification of cells are provided. A pluripotent genome is obtained from a differentiated genome by fusing a pluripotent cell with a differentiated cell in the presence of Nanog or a MEK inhibitor. A cell is genetically modified by providing first and second cells, each containing chromosomes, fusing the first cell and the second cell, and culturing the fused cell so as to obtain a diploid cell containing at least one chromosome from the first cell and at least one chromosome form the second cell. A method of cell fusion comprises fusing a first cell and a second cell in the presence of Nanog or a MEK inhibitor. Cells obtained thereby and their uses are also described. |
| IP Reference | WO2007054720 |
| Protection | Patent granted |
| Year Protection Granted | 2007 |
| Licensed | No |
| Impact | Not known |
| Title | RXR agonists to promote remylination |
| Description | RXR agonists to promote remylination |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Regionalised Endoderm cells and uses thereof |
| Description | Regionalised Endoderm cells and uses thereof |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Safely creating induced pluirpotent stem cells |
| Description | Development of creation of induced Pluripotent Stem Cells by introducing the apporiate genes using a non-viral plasmid -based method, which can be removed once the pluripotent cells have been generated. |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | Interest from commercial companies |
| Title | Use of sonication enhancement (contrast) agents for killing bacteria |
| Description | Use of sonication enhancement (contrast) agents for killing bacteria James Ross |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | No subsequent impact |
| Title | Using embryonic stem cells to generate red blood cells for clinical transfusion |
| Description | Stimulation of human embryonic stem ES cells to generate a limitless source of mature, oxygen-carrying red blood cells |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2010 |
| Licensed | No |
| Impact | Working with SNBTS, Unviersity of Glasgow, NHS Blood & transplant, the Irish Blood transfusion Service and Roslin Cells Ltd. |
| Description | Activity 'Making PlayDoh Stem Cells' |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | Activity part of the MRC Lab 'What are scientists made of, the same as you'. One of 6 stalls on making PlayDoh cells from stem cells. 15 days, total children participated in one or more activities 1,300 (MRC statistics). Organised by MRC, small contribution to development of Stem Cell activity by CRM comms officer Ingrid Heersche. Three CRM staff/studensts helped out as demonstrators at the event. Part of a general objective of disseminating infomration concerning regenerative medicine |
| Year(s) Of Engagement Activity | 2010 |
| Description | BBSRC student guide on stem cell research - May 09 - ongoing |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Primary Audience | Schools |
| Results and Impact | BBSRC is updating a booklet for secondary school students. This will be published in 2010. Scientists of the Centre (Dr Anna Williams, Dr Lesley Forrester and Dr Keisuke Kaji) have contributed a case study about their work. Post Doc Dr Nina Bauer has written part of the scientific content. Various staff have contributed to the editing process. Remains to be seen, will be published in 2010 by the BBSRC. |
| Year(s) Of Engagement Activity | 2009 |
| Description | CRM Media activity - 2008 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Various press releases & expert comments. Exposure in local, regional, national and international newspapers as well as TV (BBC news). Most important ones: - PubMed 18593562, Prof Alexander Medvinsky reports on a paper published in cell stem cell (July 08). - PubMed 18802003, Dr Ian Chambers reports on a paper published in Science (Nov 08). - Opening of the Centre (Nov 08). - Appointment of Dr Siddharthan Chandran (Nov 08). - MRC / UK Stem Cell Foundation / Scottish Enterprise £3.6M grant to find ways to repair bone & cartilage. Prof Brendon Noble (May 08). - Launch of Prof Charles ffrench-Constant's MS Centre with donation of JK Rowling (Apr 08), Emphasis on importance of research on MS by JK Rowling (July 08, newspapers as well as documentary on BBC 1 Scotland) - Schools Stem Cell Tour (Oct 08) national exposure to the general public about the work done at the centre as well as showing the importance of research on stem cell & regenerative medicine. |
| Year(s) Of Engagement Activity | 2008 |
| Description | CRM Media activity - 2009 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Various press releases & expert comments. Exposure in local, regional, national and international newspapers as well as BBC TV. Most important ones: - PubMed 19252477 and 19252478. Dr Keisuke Kaji explains about his work published in two Nature papers (March 09). - PubMed 19877180. Dr Gareth Sullivan and Prof Sir Ian Wilmut explain about the work published in Hepatology (October 09). - Collaboration between Scotland/UK and China on stem cell research and regenerative medicine (April 09). - Opening of the Euan MacDonald Centre, Prof Siddharthan Chandran (August 09). - £2.9M funding by Wellcome Trust for Prof Marc Turner on using stem cells to generate red blood cells for use in transfusions (Apr 09). - £0.4M funding by PD Society for Dr Tilo Kunath. National exposure to the general public about the work done at the centre as well as showing the importance of research on stem cell & regenerative medicine. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Centre visits |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | 12 secondary school teachers for a lab-tour, documentary films and lectures. EuroStemCell comms manager Emma Kemp and researchers Tilo Kunath and Ian Chambers involved for the day. Better equipped teachers (up to date content on stem cell research), to pass on to their secondary school students |
| Year(s) Of Engagement Activity | 2010 |
| Description | Chair of organising committee |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Primary Audience | Health professionals |
| Results and Impact | Neurology Symposium at the Royal College of Physicians, Edinburgh, October 2010 - chair of organising committee. Audience - general physicians, neurologists and students from the UK. CRM Researcher Anna Williams involved. Better informed health professionals about advances and future of regenerative medicine. |
| Year(s) Of Engagement Activity | 2010 |
| Description | Contribution to hard print booklet |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Contribution to the joint Institute of Physics and EPSRC report, "Optics and photonics: Physics enhancing our lives" available as a hard print booklet and on the web http://www.iop.org/publications/iop/2009/page_38205.html. CRM researcher Pierre Bagnaninchi involved. Book publication |
| Year(s) Of Engagement Activity | 2009 |
| URL | http://www.iop.org/publications/iop/2009/page_38205.html |
| Description | Contribution to the redevelopment of a 16+ student BBSRC booklet 'Stem Cells Science & Ethics' |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Primary Audience | Schools |
| Results and Impact | Contribution to the redevelopment of a 16+ student BBSRC booklet 'Stem Cells Science & Ethics'. Case studies from CRM researchers Anna Williams, Keisuke Kaji, Lesley Forrester. Science chapter written by CRM PostDoc Nina Bauer, edited by CRM researcher Clare Blackburn and Comms officer Ingrid Heersche. Pictures also provided. Better understanding of basic stem cell science and ethics by 16+ secondary school students. |
| Year(s) Of Engagement Activity | 2010 |
| Description | Development of teacher resources |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Development of teacher resources for secondary schools, worksheets on stem cells which can be downloaded from the EuroStemCell.org website. EuroStemCell comms manager Emma Kemp and CRM comms officer Ingrid Heersche involved. Better equipped teachers (up to date content on stem cell research), to pass on to their secondary school students |
| Year(s) Of Engagement Activity | 2010 |
| Description | Edinburgh International Science Festival - April 2008 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Keisuke Kaji explained about his recently published work in Nature at the well established Science Festival in Edinburgh. He gave a presentation and participated in workshops. Information dissemination and raising awareness. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Edinburgh University Stem Cell Science Course - April to June 2009 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | 10 week evening course on Stem Cell Science organised by Dr Clare Blackburn, Dr Sally Lowell and Dr Tilo Kunath. Classes included lectures, discussions and seeing stem cells in the laboratory. Ten other Centre researchers (all PIs) were involved and gave lectures. There were 11 students enrolled in 2008/9. We may run this course again in 2010/11. More knowledge on stem cell research in general as well as knowledge about the research done at the Centre. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Edinburgh neuroscience Christmas lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | Edinburgh neuroscience Christmas lecture, public and interested staff, overview of regenerative medicine and stem cells December 2009. CRM researchers Charles ffrench-Constant and Siddharthan Chandran involved. Awareness and understanding of degenerative diseases & regenerative medicine |
| Year(s) Of Engagement Activity | 2009 |
| Description | EuroStemCell project 2010-2014 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Start of the 2nd EuroStemCell project 2010-2014, a large European consortium of researchers that reach out to the general public via a portal website www.eurostemcell.org, public engagement component is coordinated by CRM researcher Clare Blackburn. Outreach manager Emma Kemp and Webmanager Kate Doherty are also hosted within CRM, ongoing. The eurostemcell.org website had over 95,000 unique visitors in 2009. Development of teacher resources, films & patient information, to be translated in 9 European languages. Awareness and understanding of stem cell research & regenerative medicine. |
| Year(s) Of Engagement Activity | 2010 |
| URL | http://www.eurostemcell.org |
| Description | Exhibit 'Stem Cells for Blood Transfusion?' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | Development and delivery of this exhibit together with Glasgow University and Irish and Scottish Blood Transfusion Service. Researchers Marc Turner & Lesley Forrester involved as well as CRM comms officer Ingrid Heersche. In addition 12 additional demonstrators (staff & students) for actual delivery at the event. 13,000 visitors to the exhibit (49,946 total visitors to festival). Raising awareness of stem cell applications in the future, discussing ethical issues surrounding research. |
| Year(s) Of Engagement Activity | 2010 |
| Description | Family Day - 23 November 2008 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Approximately 500 people attended this event. Many of our scientists of the Centre were involved. We hosted a free Stem Cells Family Day event at Our Dynamic Earth (ODE) in Edinburgh, as a prelude to our Launch Symposium the day after. An introduction to some of the current work being undertaken in stem cell research. Events and exhibits included the following: • stem cell and life science hands-on exhibits and presentations; • a "meet the scientist" session; • the announcement of the winners of the Stem Cell school poster competition, and the display of all of the finalists' posters; • screening of the award-winning 19 minute film, "A Stem Cell Story"; • a mini-lab, giving visitors a chance to try out some of their laboratory skills, with the following tasks: o using an ultrasound scanner to identify the contents of pre-loaded boxes (a variety of shapes and figures were embedded in opaque gel); o a microscope and flasks of stem cells - embryoid bodies, cardiomyocytes and undifferentiated stem cells - giving the lab "assistants" an opportunity to see stem cells "in the flesh"; o a simulated drug screening exercise (adding weak acid to phenol red solution, which changed colour); o loading agarose gel wells with coloured dye using real lab pipettes: this was a representation of how DNA and RNA are actually analysed in the lab. We raised awareness in the local community of Edinburgh for stem cell research and regenerative medicine in general as well for the opening of the Centre. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Four Inagural Lectures |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | Four one hour lectures by Prof Charles ffrench-Constant, Prof Jim Ross, Prof Siddharthan Chandran and Prof Marc Turner Dissemination and raising awareness at local community level on stem cells & regenerative medicine |
| Year(s) Of Engagement Activity | 2010 |
| Description | ISSCR public symposium - 07 July 2009 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | Approximately 150 people attended the ISSCR Public Symposium, organised at the CosmoCaixa science museum in Barcelona. The event included: - A 'Smile of a Stem Cell' photographic exhibition - Two short films: the award-winning film 'A Stem Cell Story' and a first-ever viewing of a soon-to-be-released film on iPS cells. - an audience-panel discussion with a group of stem cell scientists. It was co-organised by EuroSyStem, Dr Clare Blackburn and Ms Emma Kemp of the Centre were involved. More knowledge and awareness for stem cell research. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Launch Day - 24 November 2008 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | The day was organised at Our Dynamic Earth in Edinburgh. 300 invited guests from all over the world; scientific community as well as politicians and members of the MRC. The day started at 8.30am and finished at 8.00pm. After a welcome reception, the day kicked off with four scientific sessions led by our scientists Ian Wilmut, Claus Nerlov, Marc Turner, and Charles ffrench-Constant. All our PIs presented their work in a poster session, some also in separate presentations. The official launch of the Centre happened at lunchtime, the day ended with an informal networking event during a wine and canapé reception. Raising the Centre profile in the international scientific community, the life sciences sector in Scotland as well as amongst the key politicians and policy makers in Scotland. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Lecture in University "Changing World" series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | Public lecture 'The Future of Regenerative Medicine' as part of the Unversity's "Our Changing World" series. Public: general audience, students and schoolchildren, 9 November 2010, CRM researchers Charles ffrench-Constant & Siddharthan Chandran. 120 (?) attendees. Awareness and understanding of degenerative diseases & regenerative medicine |
| Year(s) Of Engagement Activity | 2010 |
| Description | Lecture to Christians in Science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Lecture to Christians in Sceince on stem cells 2009. Primary audience, Christians interested in science. CRM researcher Val Wilson involved. Awareness and understanding of basic stem cell science & ethics |
| Year(s) Of Engagement Activity | 2009 |
| Description | Lecture to Scottish MS Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Invited lecture to Scottish MS conference Perth 2010. Overview of MS and ongoing research, health professionals and patients Part of a general objective of disseminating infomration concerning regenerative medicine |
| Year(s) Of Engagement Activity | 2010 |
| Description | Presentation at Scottish Stem Cell Network |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | Public debate on the ethics of the use of embryonic stem cells Part of a general objective of disseminating infomration concerning regenerative medicine |
| Year(s) Of Engagement Activity | 2008 |
| Description | Presentation to Church group |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Description of potential uses of stem cells to derive new treatments and discussion with audience No specific outcomes |
| Year(s) Of Engagement Activity | 2009 |
| Description | Public lecture - Mexico |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | Public lecture on stem cell banking to mark opening of stem cell facility, Guadalajara , Mexico. Physicians, members of the public. CRM researcher Josh Brickman involved. Awareness and understanding of basic stem cell science & ethics |
| Year(s) Of Engagement Activity | 2010 |
| Description | Public lecture - Sofia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Schools |
| Results and Impact | Public lecture in Sofia, Bulgaria, [November 2009] as part of ESTOOLS 'Telescope' programme (for education of EU secondary students). CRM researcher Andrew Smith involved. Awareness and understanding of basic stem cell science & ethics |
| Year(s) Of Engagement Activity | 2009 |
| Description | Public lecture / event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | Part of the Big Ideas Programme. 'A Stem Cell Dream: can iPS technology be used to treat Parkinson's Disease'. Evening event where public had to vote if fictional trial had to go ahead or not. CRM researchers Tilo Kunath, Ian Wilmut and Siddharthan Chandran involved. Organised by Ingrid Heersche, chaired by BBC journalist Eleanor Bradford. 91 attendees, 14 April 2010. Part of a general objective of disseminating infomration concerning regenerative medicine |
| Year(s) Of Engagement Activity | 2010 |
| Description | Public meeting at a church |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | Public meeting at a church for 50 people, including showing the films 'A Stem Cell Story' and 'Ethics, Science and Stem Cells' as well as a lively discussion. EuroStemCell comms manager Emma Kemp and CRM researcher Clare Blackburn involved. Part of a general objective of disseminating infomration concerning regenerative medicine |
| Year(s) Of Engagement Activity | 2010 |
| Description | Response to patient enquiries - 2009 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | The Centre receives approximately 60 - 80 patient enquiries per year. Patients are looking general information on stem cell research, information about stem cell trials and clinics, and medical advice about their treatment. Due to the sensitive and specific nature of these enquiries, they are always dealt with on an individual basis by the Centre's scientific communication officer or, occasionally, by the Centre's researchers. More knowledge on stem cell research in general. The Centre has adopted a policy not to give advice regarding a specific stem cell treatment or clinical trial. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Response to patient enquiries - 2010 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | CRM receives approximately 60 - 80 patient enquiries per year that are always dealt with on an individual basis due to the sensitive and specific nature of these enquiries; we also answer approx 20 student queries per year. CRM comms officer Ingrid Heersche involved. Better informed patients & relatives about advances and future of regenerative medicine. |
| Year(s) Of Engagement Activity | 2009,2010 |
| Description | School Stem Cell Poster Competition - November 2008 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | The Stem Cell Poster Competition 2008 3 schools entered the poster competition. 2 teams from each school (S2 and senior) entered a poster. The work of the finalists and winners of was on display at the Family Day, the Launch Symposium and the Royal Society of Edinburgh's discussion forum: "Regenerative Medicine: how will it change my life?" Each S2 and senior team consisted of between two and four students, with a supervising teacher. The teams provided content and initial artwork, while the graphics and printing facilities of the University were used to realise the final posters. Engaged awareness in schools about Stem Cell Research that goes on at the Centre. |
| Year(s) Of Engagement Activity | 2008 |
| Description | School visit - 16/17 November 2009 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | Two day workshop at a local school (Liberton High School), involving 60 kids and 3 teachers (as part of a collaborative European project). Six Centre students and staff involved, including Dr Tilo Kunath. Part of the workshop was exchanging ideas with another European school. More knowledge on stem cell research in general, encouraging future scientists to work in the area of regenerative medicine, exposure for the Centre. |
| Year(s) Of Engagement Activity | 2009 |
| Description | School visits |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Schools |
| Results and Impact | Development of a stem cell lesson for use by educators as part of the EuroSyStem and EuroStemCell project. Piloted at 3 schools (368 students in total). Development done by of EuroSyStem / EuroStemCell outreach manager Emma Kemp with one CRM researcher Ian Chambers. To be finalised in 2011. Schools included Tynecastle High School (Edinburgh) and The Derby School (Lancashire) Awareness and understanding of basic stem cell science & ethics |
| Year(s) Of Engagement Activity | 2010 |
| Description | Schools Tour September - September / October 2008 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | The activity was organised together with The University of Edinburgh's SCI-Fun team. 8 local secondary schools were visited: •Peebles HS (Scottish Borders) •St George's School (Edin) •Tynecastle HS (Edin) •Newbattle CHS (Midlothian) •Preston Lodge HS (East Lothian) •Liberton HS (Edin) •St Margaret's Ac (West Lothian) •Queensferry HS (Edin) It was a morning or afternoon programme for the whole year group (S1 or S2, school decided) that consisted of: -two presentations (a stem cell show and a senses show) -a hands-on exhibit -a career show -a meet-the-scientist session (of the Centre) Total number of S1 / S2 students 1136 Total number of senior students 245 Total number of teachers 60 Engaged schools in the research that goes on at the Centre. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Stem Cell Roadshow |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Primary Audience | Schools |
| Results and Impact | Set up of SSCN Stem Cell Roadshow to secondary school pupils in Scotland as well as delivery of one of the events. 4 schools, 100 pupils in total. Researcher Dave Hay involved. Raising awareness of stem cell applications in the future, discussing ethical issues surrounding research. |
| Year(s) Of Engagement Activity | 2010 |
| Description | TickTock Media Ltd student guide on stem cell research - Sept 09 - ongoing |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | TickTock MEDIA LTD, a publisher of educational materials, are producing a booklet for secondary school students on Stem Cell Technology. This will be published in 2010. Professor Sir Ian Wilmut has contributed a case study about his work. Various staff have contributed to the editing process. Remains to be seen, will be published in 2010. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Various press releases & expert comments |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Various press releases & expert comments with exposure in local, regional, national and international newspapers as well as TV (STV news). Part of a general objective of disseminating infomration concerning regenerative medicine |
| Year(s) Of Engagement Activity | 2010 |
| Description | Visits / talks / written interviews for patient groups |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Several lectures to patient groups by several researchers, total number of patients involved approx 100 (MS branches in Perth and Irvine; Leukaemia and Lymphoma Research Scotland, Parkinson's UK). Researchers Charles ffrench-Constant, Anna Williams, Tilo Kunath and Clare Blackburn involved. Better informed patients & relatives about advances and future of regenerative medicine |
| Year(s) Of Engagement Activity | 2010 |
| Description | Visits / talks / written interviews for patient groups - 2009 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Various visits and talks to patient groups, including: - Dr Anna Williams hosted a stem cell workshop at MS Myspace conference for MS patients and their families in Perth. - Dr Anna Williams gave a lecture and Q&A meeting at Craighall MS Community Group. - Following a donation of £10k for the Kinross branch of the MS Society Dr Anna Williams hosted a visit of the group at the Centre. - Dr Tilo Kunath has had visits from various individual Parkinsons patients. - Dr Tilo Kunath hosted a visit at the Centre for the PD Society's branch Edinburgh Young Parkinson's. - Several interviews in (local) patient group magazines, including MS Society and PD Society. dissemination and raising awareness at local community level as well as national level. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Visits / talks/ written inteviews for patient groups - 2008 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Various visits and talks to patient groups, including: - MS Life lecture 2008 (Glasgow) - a meeting of the MS Society for patients and families - Hosted a visit by our principal donor JK Rowling. dissemination and raising awareness at local community level as well as national level. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Visits for students and secondary school children - 2009 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | Various activities, including: - An afternoon programme for 20 American exchange students, involving two lectures by Prof Sir Ian Wilmut and Prof Stuart Forbes as well as a lab tour (Oct 09). - A visit from 3 secondary school students from a local school. Hosted by Dr Tilo Kunath and Dr Keisuke Kaji. More knowledge on stem cell research in general, encouraging future scientists to work in the area of regenerative medicine, exposure for the Centre. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Workshop on stem cells & resources |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Primary Audience | Schools |
| Results and Impact | Workshop on stem cells & resources for secondary school teachers as part of the annual ASE conference, 16 participants. EuroStemCell comms manager Emma Kemp and CRM comms officer Ingrid Heersche involved. Better equipped teachers (up to date content on stem cell research), to pass on to their secondary school students |
| Year(s) Of Engagement Activity | 2010 |
| Description | X-mas lecture at University of Edinburgh - 04 December 2009 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof Charles ffrench-Constant and Prof Siddharthan Chandran on 'Stem Cells for Neurological Disorders - where now' (Dec 09). Approx 300 people attended this lecture, which was followed by a short Q&A session and a drink. Available online: http://www.edinburghneuroscience.ed.ac.uk/christmaslecture/2009/ More knowledge on stem cell research in general as well as exposure for all the Centres involved (CRM, MS Centre, Euan MacDonald Centre). |
| Year(s) Of Engagement Activity | 2009 |