Enhancing the propagation of ES cells by regulation of visceral endoderm differentiation

Lead Research Organisation: University of Liverpool
Department Name: Human Anatomy and Cell Biology

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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He X (2010) Rac1 is essential for basement membrane-dependent epiblast survival. in Molecular and cellular biology

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Jakobsson L (2008) Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology

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Kalaskar DM (2013) Characterization of the interface between adsorbed fibronectin and human embryonic stem cells. in Journal of the Royal Society, Interface

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Murray P (2013) The self-renewal of mouse embryonic stem cells is regulated by cell-substratum adhesion and cell spreading. in The international journal of biochemistry & cell biology

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Rak-Raszewska A (2012) Development of embryonic stem cells in recombinant kidneys. in Organogenesis

 
Description Member of the Horizon Scanning Panel of the Human Fertilisation and Embryology Authority
Geographic Reach National 
Policy Influence Type Participation in advisory committee
Impact Provision of information and analysis of new scientific developments that could affect the remit of the HFEA in future
 
Description UK Stem Cell Network
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact Government-instigated organisation to facilitate stem cell research in the UK; Establishment of a framework for the interactions of the National and Regional Stem cells Networks
 
Description BBSRC Equipment Grant
Amount £180,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2007 
End 03/2008
 
Description EPSRC Project Grant
Amount £200,116 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 11/2009 
End 04/2011
 
Description EU Marie Curie Actions RTN
Amount £378,000 (GBP)
Organisation Marie Sklodowska-Curie Actions 
Sector Academic/University
Country Global
Start 09/2006 
End 08/2010
 
Description MRC Project Grant
Amount £255,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2009 
End 03/2011
 
Description Stem Cells for Safer Medicines (SC4SM)
Amount £339,778 (GBP)
Organisation Stem Cells for Safer Medicines (SC4SM) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2008 
End 12/2010
 
Title Synthetic substrates for stem cell culture 
Description We have designed novel polymeric synthetic substrates that we have shown can be used for the tissue culture of embryonic stem cells under defined conditions (see Zhang et al.,Adv. Funct. Mater. 2008, 18, 222-228) 
Type Of Material Technology assay or reagent 
Year Produced 2009 
Provided To Others? Yes  
Impact We are going on to use such substrates as the basis of design for modified polymer and synthetic peptide substrates with which ES cell behaviour can be controlled. The work resulted in the award of an on-going strategic project grant from the BBSRC/EPSRC together with collaborative grants awarded from the Stem Cells for Safer Medicines (SC4SM) initiative 
 
Description Liverpool Echo 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Subsequent to press release by the University of Liverpool, we had several requests for interviews and these resulted in articles appearing in the local press.

Resulting from press articles, we have had phone contacts with members of the public seeking more information
Year(s) Of Engagement Activity 2006
 
Description University of Liverpool Stem Cell Consortium website 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact Our website has a outreach section designed for public viewing which presents an overview and explanation of our work

Over the last few years we have had summer students from local schools gaining work experience in the lab. The work has resulted in the production of posters by these students.
Year(s) Of Engagement Activity 2006