Detecting Susceptibility Genes for Late-Onset Alzheimer s Disease
Lead Research Organisation:
University of Wales
Department Name: UNLISTED
Abstract
Alzheimer s disease (AD) is a serious debilitating disorder which costs society more than stroke, heart disease and cancer combined. As more people survive to a greater age, the number of AD sufferers is likely to grow considerably. In recent years the identification of some of the genes involved in AD has resulted in a deeper understanding of how the disease develops. However, there are more genes involved, especially in the common forms of AD with onset in later life. This programme of research aims to identify a gene or genes in a region of chromosome 10 showing very strong evidence of containing at least one susceptibility gene for late-onset AD. We will screen this region intensively using a large sample of over 3000 individuals (MRC Genetic Resource for AD) with AD and without. We will also look for relationships between AD and genes showing compelling evidence of functional involvement in other chromosomal regions likely to contain genes. Finally, we will follow-up the MRC Genetic Resource to produce a sample capable of detecting genes which modify disease symptoms (e.g. Psychosis) and course, as well as those that increase disease risk. The knowledge gained from identifying new genes for AD will provide an important platform for future therapeutic developments.
Technical Summary
Alzheimer?s disease (AD) is a common debilitating disorder with a prevalence that rises steeply with age from below 1% at 65 years to as high as 40% after the age of 90. Current projections suggest that the number of elderly will double in the next generation, resulting in more than a billion people over the age of 60 by 2025 in Europe alone. In the UK the direct costs of AD are between 7 and 14 billion pounds per year, approximately the same as those of stroke, heart disease and cancer combined. The predicted increase in the prevalence of AD will undoubtedly have an enormous impact on society. Therefore, gaining a more complete understanding of the genetic contribution to AD must be a priority, as it will provide a strong platform for the development of future preventative and therapeutic strategies. There is no doubt that genes play an important role in the aetiology of late-onset AD, the most common form of Alzheimer s disease (LOAD). This research programme seeks to identify novel genes contributing to the risk and/or the course of LOAD. There is compelling evidence for a gene or genes on chromosome 10. We will localize the peak/s within this region using high density linkage in a large series of families with AD.
We will identify the susceptibility genes in the peak/s, using linkage disequilibrium mapping and direct gene analysis. In addition, we will test for association between AD and functional candidate genes in other regions of linkage throughout the genome. Finally, we will maintain and consolidate the largest case-control sample available to the AD genetics research community and create a resource capable of identifying disease modifying, as well as disease susceptibility genes.
We will identify the susceptibility genes in the peak/s, using linkage disequilibrium mapping and direct gene analysis. In addition, we will test for association between AD and functional candidate genes in other regions of linkage throughout the genome. Finally, we will maintain and consolidate the largest case-control sample available to the AD genetics research community and create a resource capable of identifying disease modifying, as well as disease susceptibility genes.
Organisations
- University of Wales, United Kingdom (Lead Research Organisation)
- University College London, United Kingdom (Collaboration)
- VU University Medical Center (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- University of Bonn, Germany (Collaboration)
- Grants Admin Office (Collaboration)
- University of Cambridge, United Kingdom (Collaboration)
- Medical Research Council (Collaboration)
- University of Exeter, United Kingdom (Collaboration)
- Pasteur Institute, Lille (Collaboration)
- Hospital de Sant Pau (Collaboration)
- Quest Diagnostics (Collaboration)
- Erasmus University Medical Center, Netherlands (Collaboration)
- Genomics England (Collaboration)
- National Center for Biotechnology Information (NCBI) (Collaboration)
- National Institute of Health and Medical Research (INSERM) (Collaboration)
- University of Pennsylvania, United States (Collaboration)
- King's College London, United Kingdom (Collaboration)
Publications
Proitsi P
(2012)
Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia.
in Neurobiology of aging
Reitz C
(2011)
Meta-analysis of the association between variants in SORL1 and Alzheimer disease.
in Archives of neurology
Schürmann B
(2011)
Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.
in Journal of Alzheimer's disease : JAD
Seshadri S
(2010)
Genome-wide analysis of genetic loci associated with Alzheimer disease.
in JAMA
Sims R
(2017)
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
in Nature genetics
Sims R
(2009)
Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease.
in Neuroscience letters
Smemo S
(2006)
Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease.
in Annals of neurology
Staley LA
(2016)
Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels.
in BMC genomics
Staley LA
(2016)
Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid.
in BMC genomics
Thomas RS
(2016)
Decreasing the expression of PICALM reduces endocytosis and the activity of ß-secretase: implications for Alzheimer's disease.
in BMC neuroscience
| Description | Academy Medical Sciences Council Member |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | Academy Medical Sciences Fellow |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Description | Academy Medical Sciences Wales Ambassador |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | Chief Scientific Advisor to Alzheimer's Research Trust |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in advisory committee |
| Description | Department of Health Advisory Group on Dementia |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guidance committee |
| Description | Department of Health Advisory Group on Dementia |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | EPAD LCS sample access committe |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Description | Medicines Discovery Institute MDI |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | NMHRI management |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | Welsh Assembly Government Advisory Group on Dementia |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in a advisory committee |
| Description | A high content analysis platform for analysing dementia-associated genetic variation |
| Amount | £108,300 (GBP) |
| Funding ID | ARUK-EG2017A-1 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 09/2017 |
| Description | ABBUK Brains for Dementia Research Programme (extension) |
| Amount | £404,390 (GBP) |
| Funding ID | 504291 |
| Organisation | Alzheimer’s Brain Bank UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2013 |
| End | 03/2018 |
| Description | Brains for dementia research |
| Amount | £161,915 (GBP) |
| Funding ID | ART-RF2009-3 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Centre for Ageing and Dementia Research - 2 Year Extension |
| Amount | £1,200,000 (GBP) |
| Funding ID | 514840 |
| Organisation | Government of Wales |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2020 |
| Description | Clinical collection supply agreement to investigate the genetics of Alzheimer's disease/Glaxosmithkline Research & Development |
| Amount | £532,000 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | |
| Description | Dyslexia genes and neurobiological pathways (NEURODYS) |
| Amount | £251,460 (GBP) |
| Funding ID | 18696 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Evaluation of candidate genomic regions to determine genetic pedisposition in populations of Alzheimer's patients |
| Amount | £168,514 (GBP) |
| Funding ID | 092008 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Grant for the establishment of an ART AD research centre |
| Amount | £203,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | In vivo imaging of Tau distribution in the brain |
| Amount | £44,743 (GBP) |
| Organisation | Welsh Local Government Association |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 03/2017 |
| Description | Industrial Collaborative Studentship - A novel approach to identifying new susceptibility genes for late on-set Alzheimer's disease and its sub components |
| Amount | £52,645 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | NEURODEM/National Assembly for Wales via Bangor University |
| Amount | £41,674 (GBP) |
| Organisation | Health and Care Research Wales |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | The development and implementation of polygenic risk algorithms for stratifying individuals for future cognitive decline due to Alzheimers disease |
| Amount | £298,040 (GBP) |
| Funding ID | 2018/20180222 |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2020 |
| Description | Therapeutic targeting of impaired lysosomal flux in Alzheimer's disease |
| Amount | £136,502 (GBP) |
| Funding ID | MR/P007651/1 |
| Organisation | Network of Centres of Excellence in Neurodegeneration (COEN) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 10/2017 |
| Description | Translating new susceptibility genes for Alzheimer's Disease through clinical characterisation and epidemiology/Welsh Assembly Government |
| Amount | £148,348 (GBP) |
| Organisation | Health and Care Research Wales |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Wellcome Trust Project Grant (A Powerful, Genome-Wide Association Scan for Susceptibility Genes for late-onset Alzheimer's disease) |
| Amount | £286,504 (GBP) |
| Funding ID | 082604/B/07/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Title | AD Genetics Scotland |
| Description | Blood samples are collected from participants and sent directly from research sites to European Collection of Authenticated Cell Cultures (ECACC), a Culture Collection of Public Health England. Upon arrival, ECACC process the blood and transform into cell lines- peripheral blood lymphocytes (PBLs) and Lymphoblastoid cell lines (LCLs). Cell lines are frozen and stored at ECACC until they are required by the team at Cardiff. |
| Type Of Material | Biological samples |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | Ongoing collection of samples, no publications to date. |
| Title | Brain Bank - Alzheimers |
| Description | We have recently created a brain bank based upon the longitudinal sample, to provide the wider research community with multiple tissue samples on well characterised individuals. |
| Type Of Material | Biological samples |
| Year Produced | 2007 |
| Provided To Others? | Yes |
| Impact | Multiple publications and media coverage |
| Title | DLB Genetics |
| Description | Blood samples are collected from participants and sent directly from research sites to European Collection of Authenticated Cell Cultures (ECACC), a Culture Collection of Public Health England. Upon arrival, ECACC process the blood and transform into cell lines- peripheral blood lymphocytes (PBLs) and Lymphoblastoid cell lines (LCLs). Cell lines are frozen and stored at ECACC until they are required by the team at Cardiff |
| Type Of Material | Biological samples |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | Ongoing collection of samples, no publications to date |
| Title | Plcg2 animal models |
| Description | To establish a functional pipeline for the study of disease associated genes and polymorphism in microglia and MØ in the context of dementia-related disease in vivo. The initial concentration is on the impact of coding mutations of PLCG2. In parallel, studies were initated on SPI1 and ABI3. Large scale 'omic and functional assay data derived from these studies will be used to bioinformatically identify potential causative abnormalities, by association with patient data |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | n/a |
| Title | Polygenic score |
| Description | With 80,000 variants included to create a measure of risk of Alzheimer's disease, the polygenic score is an excellent predictive tool to determine case/control status with high accuracy. The polygenic score encompasses the majority of genetic risk of disease, and can be fine-tuned to identify the pathways involved in disease, for example, immune cell activity or endocytosis. |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | We are working to translate this method from the basic science environment in which it was created into a predictive tool used to select participants for clinical trials, based on their disease status and type. We are currently in discussions with a number of potential collaborators to take this forward. |
| Title | GERAD GWAS |
| Description | Genome-wide association study data of over 3,000 AD cases and 7,000 controls |
| Type Of Material | Database/Collection of data |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | multiple publications |
| Title | IGAP dataset |
| Description | Mega-meta analysis data of over 17,000 AD cases and 30,000 controls |
| Type Of Material | Database/Collection of data |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | Lambert et al. 2013 (PMID:24162737), Escott-Price et al. 2014(in press), Farrer et al. 2014 (submitted) |
| Description | ADES Collaboration |
| Organisation | Erasmus University Medical Center |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this. |
| Collaborator Contribution | as above |
| Impact | n/a |
| Start Year | 2016 |
| Description | ADES Collaboration |
| Organisation | Hospital de Sant Pau |
| Country | Spain |
| Sector | Hospitals |
| PI Contribution | A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this. |
| Collaborator Contribution | as above |
| Impact | n/a |
| Start Year | 2016 |
| Description | ADES Collaboration |
| Organisation | National Institute of Health and Medical Research (INSERM) |
| Country | France |
| Sector | Public |
| PI Contribution | A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this. |
| Collaborator Contribution | as above |
| Impact | n/a |
| Start Year | 2016 |
| Description | ADES Collaboration |
| Organisation | Pasteur Institute, Lille |
| Country | France |
| Sector | Charity/Non Profit |
| PI Contribution | A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this. |
| Collaborator Contribution | as above |
| Impact | n/a |
| Start Year | 2016 |
| Description | ADES Collaboration |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this. |
| Collaborator Contribution | as above |
| Impact | n/a |
| Start Year | 2016 |
| Description | ADES Collaboration |
| Organisation | University of Bonn |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this. |
| Collaborator Contribution | as above |
| Impact | n/a |
| Start Year | 2016 |
| Description | ADES Collaboration |
| Organisation | University of Pennsylvania |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this. |
| Collaborator Contribution | as above |
| Impact | n/a |
| Start Year | 2016 |
| Description | ADES Collaboration |
| Organisation | VU University Medical Center |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this. |
| Collaborator Contribution | as above |
| Impact | n/a |
| Start Year | 2016 |
| Description | Clinical collection supply agreement to investigate the genetics of Alzheimer's disease |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | We collected 200 AD cases with full clinical work up including volumetric neuroimaging and DNA sampling. |
| Collaborator Contribution | GSK funded the collection and storage of DNA samples and clinical and neuroimaging measures on 200 Alzheimer's disease cases in the early stages of disease. |
| Impact | 17998437 19013250 |
| Description | Finding genes for late onset Alzheimer's disease: Collaboration between Washington University, NIMH, Cardiff University and Celera Diagnostics |
| Organisation | Quest Diagnostics |
| Department | Celera Diagnostics |
| Country | United States |
| Sector | Private |
| PI Contribution | We undertook a genomewide association study of Alzheimer's disease using genetic pooling and also tested associations with candidate genes. The Celera Diagnostics through a sub-contract with MERCK paid for the genomewide association genotyping. Our group took the lead on some studies and contributed samples and intellectual input on others but at all stages all decisions about research design etc were undertaken jointly in a full collaborative fashion. This built on a previous collaboration between ourselves and Allison Goates group from Washington University which spanned over a decade. |
| Collaborator Contribution | Our collaborative group including Celera Diagnostics, Allison Goate and John Hardys research groups undertook a genomewide association study of Alzheimer's disease using genetic pooling and also tested associations with candidate genes. Celera Diagnostics through a sub-contract with MERCK paid for the genomewide association genotyping. Our group took the lead on some studies and contributed samples and intellectual input on others but at all stages all decisions about research design etc were undertaken jointly in a full collaborative fashion. This built on a previous collaboration between ourselves and Allison Goates group from Washington University which spanned over a decade. |
| Impact | 17949987 17492769 17725986 18063669 16161859 16385451 16278862 16847012 17317784 |
| Description | Genome-wide Association Studies |
| Organisation | National Center for Biotechnology Information (NCBI) |
| Country | United States |
| Sector | Public |
| PI Contribution | Led and co-ordinated the study that involved the work of the following collaborators: 1 MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. 2 NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Kings College, London, UK. 3 Department of Neuroscience, Institute of Psychiatry, Kings College, London, UK. 4 Institute of Public Health, University of Cambridge, Cambridge, UK. 5 Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. 6 Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland. 7 Institute of Genetics, Queen's Medical Centre, University of Nottingham, NG7 2UH, UK. 8 Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK. 9 Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK. 10 Clinical Neuroscience Research Group, Greater Manchester Neurosciences Centre, University of Manchester, Salford, UK. 11 Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK. 12 Dementia Research Group, University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK. 13 Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, UK. 14 MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. 15 Dementia Research Centre, Department of Neurodegenerative Diseases, University College London, Institute of Neurology, London, UK. 16 Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany. 17 Institute of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Germany. 18 Department of Psychiatry, Charité Berlin, Germany. 19 Department of Psychiatry and Psychotherapy, University of Erlangen-Nüremberg, Germany. 20 LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, University Duisburg-Essen, Germany. 21 Institute for Stroke and Dementia Reserach, Klinikum der Universität München, Marchioninistr. 15, 81377, Munich, Germany. 22 Department of Neurology, Klinikum der Universität München, Marchioninistr. 15, 81377, Munich, Germany. 23 Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, D-68161 Mannheim, Germany. 24 Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Laboratory of Neuroimaging & Biomarker Research, Trinity College, University of Dublin, Ireland. 25 Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany. 26 Centre for Geriatric Medicine and Section of Gerontopsychiatry and Neuropsychology, Medical School, University of Freiburg, Germany. 27 Departments of Psychiatry, Neurology and Genetics, Washington University School of Medicine, St Louis, MO 63110, US. 28 Department of Biology, Brigham Young University, Provo, UT, 84602, USA. 29 Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerpen, Belgium. 30 Institute Born-Bunge and University of Antwerp; Antwerpen, Belgium. 31 Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium. 32 Department of Mental Health Sciences, University College London, UK. 33 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. 34 MRC Centre for Neurodegeneration Research, Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London, SE5 8AF, UK. 35 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece. 36 Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA. 37 Department of Genomics, Life & Brain Center, University of Bonn, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany. 38 Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, D-53111 Bonn, Germany. 39 Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Hufelandstr. 55, D-45147 Essen, Germany. 40 Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany. 41 Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany. 42 Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA. 43 Division of Biomedical Statistics and Informatics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA |
| Collaborator Contribution | This group of 45 collaborators all contributed towards the centres Genome-wide association study |
| Impact | The study, published in Nature Genetics (PubMed ID 19734902), has uncovered two new genes associated with Alzheimer's disease. Previously only one gene, APOE4, had been shown to be a risk factor for Alzheimer's disease. The study reveals, for the first time, that two further genes, CLU and PICALM, are related to Alzheimer's disease. This has led to worldwide media coverage. The data produced is still used in new studies with requests coming in to the host institution every few weeks. |
| Start Year | 2009 |
| Description | Genomics England |
| Organisation | Genomics England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | We are in the very early stages of discussion with Genomics England, but we hope to be able to use their facilities for whole Genome sequencing. This will mean that we generate valuable data on the largest EOAD cohort world-wide. |
| Collaborator Contribution | Genomics England have the equipment and infrastructure set up for the very expensive and technical whole exome sequencing. |
| Impact | None yet |
| Start Year | 2015 |
| Description | MRC AD Cohort |
| Organisation | King's College London |
| Department | Institute of Psychiatry, Psychology & Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We contributed DNA, clinical follow up information, genotyping and other laboratory work and complex data analysis. |
| Collaborator Contribution | The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. |
| Impact | 16970641 17322133 17530621 17440948 17440933 17373700 17999207 18163421 |
| Description | MRC AD Cohort |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Centre for Developmental Neurobiology |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | We contributed DNA, clinical follow up information, genotyping and other laboratory work and complex data analysis. |
| Collaborator Contribution | The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. |
| Impact | 16970641 17322133 17530621 17440948 17440933 17373700 17999207 18163421 |
| Description | MRC AD Cohort |
| Organisation | Trinity College Dublin |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | We contributed DNA, clinical follow up information, genotyping and other laboratory work and complex data analysis. |
| Collaborator Contribution | The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. |
| Impact | 16970641 17322133 17530621 17440948 17440933 17373700 17999207 18163421 |
| Description | MRC AD Cohort |
| Organisation | University of Cambridge |
| Department | Department of Medical Genetics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We contributed DNA, clinical follow up information, genotyping and other laboratory work and complex data analysis. |
| Collaborator Contribution | The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. |
| Impact | 16970641 17322133 17530621 17440948 17440933 17373700 17999207 18163421 |
| Description | MRC AD Cohort |
| Organisation | University of Cambridge |
| Department | Department of Public Health and Primary Care |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We contributed DNA, clinical follow up information, genotyping and other laboratory work and complex data analysis. |
| Collaborator Contribution | The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. |
| Impact | 16970641 17322133 17530621 17440948 17440933 17373700 17999207 18163421 |
| Description | PROTECT / CHARIOT-Pro / Cardiff DPUK |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Genotyping of 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be completed by Cardiff Univ as part of a collaboration funded by Dementias Platform UK. Polygenic risk scores will be calculated for these individuals and data made available via DPUK Platform. |
| Collaborator Contribution | DNA samples from 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be sent to Cardiff Univ for genotyping |
| Impact | None to date - work in progress. Collaboration is multi-disciplinary - Neurology, Neuroepidemiology & Ageing; Genetics & Genomics; Psychiatry |
| Start Year | 2018 |
| Description | PROTECT / CHARIOT-Pro / Cardiff DPUK |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Genotyping of 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be completed by Cardiff Univ as part of a collaboration funded by Dementias Platform UK. Polygenic risk scores will be calculated for these individuals and data made available via DPUK Platform. |
| Collaborator Contribution | DNA samples from 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be sent to Cardiff Univ for genotyping |
| Impact | None to date - work in progress. Collaboration is multi-disciplinary - Neurology, Neuroepidemiology & Ageing; Genetics & Genomics; Psychiatry |
| Start Year | 2018 |
| Description | PROTECT / CHARIOT-Pro / Cardiff DPUK |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Genotyping of 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be completed by Cardiff Univ as part of a collaboration funded by Dementias Platform UK. Polygenic risk scores will be calculated for these individuals and data made available via DPUK Platform. |
| Collaborator Contribution | DNA samples from 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be sent to Cardiff Univ for genotyping |
| Impact | None to date - work in progress. Collaboration is multi-disciplinary - Neurology, Neuroepidemiology & Ageing; Genetics & Genomics; Psychiatry |
| Start Year | 2018 |
| Title | Diagnosis of Alzheimer's Disease |
| Description | The work has also been published and has achieved a huge amount of media coverage. This discovery of three further genes associated with Alzheimer's disease could provide valuable new leads in the race to find treatments and possibly cures for the devastating condition. This patent application resulted from Julie Williams, Professor of Neuropsychological Genetics and Professor Mike Owen, Professor and Head of MRC Centre, completing the largest-ever joint Alzheimer's disease genome-wide association study (GWAS) involving 16,000 individuals. The patenting of theseSNPS is still in progress and a reveiew is currently underway to identify the best route to exploitation of the technology. |
| IP Reference | WO2011001135 |
| Protection | Patent granted |
| Year Protection Granted | 2012 |
| Licensed | No |
| Impact | This has had huge worldwide impact through media coverage and was originally highlighted in the press with the discovery of an additional 5 genes. We are currently in the process of seeking a licencee for the patented technology which encompasses a diagnostic test for the protected gene SNPs. Recent advances include generation of a polygenic score including the licensed SNPs for the detection of AD risk. We are working together with industry on basic genetic testing, cohort studies, cognitive test providers and pathway specific therapies for new ways in which to combat Alzheimer's disease. |
| Description | "Novel Approach to gene-based analysis of Alzheimer's Disease Informed by Genetics of Psychiatric Disorders" Presentation by Emily Baker, Alzheimer's Association International Conference, London 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation to discuss novel approaches to the genetic analysis of Alzheimer's Disease, subsequently presenting data obtained using these methods to fellow geneticists, Alzheimer's Disease researchers and clinicians. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.alzheimersanddementia.com/article/S1552-5260(17)30993-7/abstract |
| Description | "POLARIS: Polygenic LD-Adjusted Risk Score approach for analysis of GWAS data" Presentation by Emily Baker, American Society of Human Genetics, Orlando 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation to discuss novel approaches to the genetic analysis of Alzheimer's Disease, subsequently presenting data obtained using these methods to fellow geneticists, Alzheimer's Disease researchers and clinicians. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://ep70.eventpilotadmin.com/web/page.php?page=IntHtml&project=ASHG17&id=170120507 |
| Description | 2 new genetic variations linked with Alzheimer's |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | An international collaboration of scientists, including expertise from Cardiff University, has uncovered two new genetic variations linked with Alzheimer's, opening up new research avenues into the disease. The two newly discovered genetic variations do not predict a person's risk of developing Alzheimer's, but the authors of the paper, which appears in The Journal of the American Medical Association (JAMA) speak of new valuable insights for scientists working on the disease. Professor Julie Williams, Cardiff University, is a principal investigator of the study, led by Professor Monique Breteler, University Medical Center Rotterdam. The research also builds on the discovery led by Professor Williams last year of the first new genes associated with Alzheimer's in a generation. Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | ART - Westminster |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Dissemination of research findings to parliamentarians not known |
| Year(s) Of Engagement Activity | 2010 |
| Description | ART Event - Bournemouth |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Disseminating research findings to research participants not know |
| Year(s) Of Engagement Activity | 2009 |
| Description | ART Public Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented research findings as part of the ART public lecture "New Alzheimer's genes: What do they mean?" Not Known |
| Year(s) Of Engagement Activity | 2010 |
| Description | ARUK 2014 Annual Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Julie Williams took part in a debate at the 2014 ARUK conference titled: Alzheimer's disease: The relative importance of Genes and Environment The conference audience took part in the debate and positive feedback was recieved about this part of the conference. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.alzheimersresearchuk.org/conference-programme/ |
| Description | ARUK Iceland donation press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A press release was issued announcing new funding from ARUK raised by Iceland foods The press release mentioned research investigating Early Onset AD, this resulted in an increase in enquiries about research |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.alzheimersresearchuk.org/news-detail/10984/Cardiff-researchers-lead-global-hunt-for-early... |
| Description | ARUK Public Engagement open day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Public engagement |
| Year(s) Of Engagement Activity | 2015 |
| Description | ARUK Scientific meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Scientific meeting |
| Year(s) Of Engagement Activity | 2015 |
| Description | Alzheimer's gene study achieves landmark breakthrough |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Cardiff University publicised publication in Nature Genetics "Genetic meta-analysis of diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing" - aiming to raise public awareness of research being undertaken at UK Dementia Research Institute Cardiff |
| Year(s) Of Engagement Activity | 2019 |
| Description | Alzheimers Society Visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Health professionals |
| Results and Impact | presented research findings to representatives of ART at a visit hosted by the Dean of Medicine, Cardiff University not known |
| Year(s) Of Engagement Activity | 2010 |
| Description | Annual ART Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Attended and presented at the annual ART conference not known |
| Year(s) Of Engagement Activity | 2010 |
| Description | Awarded £800K to lead new genetic research into Alzheimer's |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Professor Julie Williams, School of Medicine, has been awarded £800K to lead new genetic research into Alzheimer's (Business Weekly, 14.10.10) Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | BBC (online and local news) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof Julie Williams on AD gene study |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.co.uk/news/uk-wales-36286847 |
| Description | BBC Panorama |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof Julie Williams Research Team were approached to be involved in a BBC documentary. The documentary followed one of our research participants and his family through everyday life with Alzheimer's disease. Field workers and laboratory staff were also filmed in their roles. The documentary was screened on BBC1 in Panorama on 2nd June 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | BBC Wales Dementia Week 2016 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Filming with BBC Wales's Owain Clarke on Thursday (12th May, 10-12). Interview is part of a package he's doing for Alzheimer's Awareness Week. Owain will be asking Prof Williams about Wales's research contribution; her own specific research and; look ahead at what's next. Various excerpts were screened on BBC news throughout the week, featuring a number of different staff from the team at Cardiff. This raised awareness of our work and the profile of the team. |
| Year(s) Of Engagement Activity | 2016 |
| Description | BBC Wales evening news UK DRI Cardiff official opening |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview of Professor Julie Williams to publicise official opening of UK DRI Cardiff. Prof Williams explained the purpose of the DRI, its multi-targeted approach, and the funding that had enabled attraction of world class scientists to Cardiff. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.bbc.co.uk/iplayer/episode/b0bp0k0t/bbc-wales-today-evening-news-25102018# |
| Description | BBC panorama |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | BBC Panorama are following an EOAD participant. The initial interview was filmed by the BBC |
| Year(s) Of Engagement Activity | 2016 |
| Description | BBC radio interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Radio interview BBC Forty research groups led by scientists in Cardiff, France and the United States have been working more closely together and have now pooled a worldwide database of 90,000 samples. "We're about to submit a paper that is enormously exciting and which I think will really change, without a doubt, what we think of Alzheimer's disease going forward," Professor Julie Williams, head of the research team at Cardiff University, said. "Over the last five or six years we've been successful in identifying 30 genes that increase - or decrease - your risk for Alzheimer's disease. Now this is telling us what some of the major components in disease development are. It's new, it's exciting; it's a different perspective on what Alzheimer's disease is." |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.bbc.co.uk/news/uk-wales-36286847 |
| Description | British Science Festival 2016 Workshops |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | We used VR tools to demonstrate the impact of dementia on people's everyday lives. These included using the experiences "A Walk Through Dementia", our citizen science game "Sea Hero Quest", some activities from out children's website, as well as hands on activities and memory games. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.britishsciencefestival.org/ |
| Description | CADR Annual Public Conference, 5th October 2016 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The Centre for Aging and Dementia Research (CADR) annual public meeting was held on 5th October in City Hall, Cardiff. A variety of individuals attended including the general public, and NHS staff working in dementia. Feedback received indicated that the event was regarded as training for NHS staff. Discussion groups were lively, and focused on clinical dementia. A number of information stands were manned during the meeting, including an ARUK stand, a Cardiff University Alzheimer's Team Recruitment stand, a Join Dementia Research (JDR) Stand, and a variety of others. The Cardiff research team have had an increased number of volunteer queries. We have also furthered collaborations with CFAS Wales, Dr John Hindle (DLB/PD expert) and others as a direct result of this meeting. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.cadr.cymru/en/ |
| Description | CADR Presentation to Minister |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | The Welsh Assembly Government Minister for Health visited Swansea University on 15th August, 2016. CADR staff/scientific leads were asked to prepare short presentations to inform the Minister of the on-going work of the research teams involved in CADR. Prof Julie Williams gave a brief presentation about the research of her team |
| Year(s) Of Engagement Activity | 2016 |
| Description | Cardiff Scientific Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk entitled - The Genetics underlying late-onset Alzheimer's Disease Not Known |
| Year(s) Of Engagement Activity | 2010 |
| Description | Cardiff experts call for Alzheimer's action |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Cardiff experts have been at the forefront of calls to step up the battle against Alzheimer's Disease in the press and on national television following a leading international conference on the disease. Nationwide media coverage including the BBC news Will lead to increased public awareness |
| Year(s) Of Engagement Activity | 2010 |
| Description | Defining the genetic architecture of AD |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Rome 28th February 2011 - Invited speaker Unknown |
| Year(s) Of Engagement Activity | 2011 |
| Description | Defining the genetic architecture of Alzheimer's disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | Alzheimer's Research Trust Research Day - Manchester ART Centre, Chancellors conference centre 27th January 2011 - Keynote speaker Unknown |
| Year(s) Of Engagement Activity | 2011 |
| Description | Distribution of news letter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | We distribute a 4-8 page newsletter annually to participants in our research, their families and healthcare professionals At present just over 1000 people receive our newsletter. The newsletter helps engage the public in our research and we receive a large amount of positive feedback from it. We also hope that the newsletter has a positive impact on retention of participants in longitudinal aspects of our research. |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | EISA Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Delivered talk entitled - Dementia and Cognitive Dysfunction Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | Funding for Alzheimer's research |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Scientists in Wales researching the causes of dementia are at a "major disadvantage" because the nation does not fund such projects says Professor Julie Williams, School of Medicine. (Western Mail, 4/2/10, p14) Professor Williams is also interviewed about funding for Alzheimer's research. (BBC Wales News, 4/2/10) Unknown |
| Year(s) Of Engagement Activity | 2009 |
| Description | Funding for Alzheimer's research |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Professor Julie Williams, School of Medicine, is interviewed regarding funding for Alzheimer's research. (BBC Radio Wales, 2.2.10) Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | Genome wide association study of Alzheimer's disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Invited Plenary - International Conference on Alzheimer's disease (ICAD) - Vienna - July 2009 Unknown |
| Year(s) Of Engagement Activity | 2009 |
| Description | Global media coverage |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | In September 2009 we published evidence of two new genes which are associated with susceptibility to Alzheimer's disease. This research generated substantial media interest both nationally and internationally. To see the BBC coverage of this story please visit: http://news.bbc.co.uk/1/hi/wales/8239773.stm. The story was covered in over 70 high quality publications (a full list is provided at the bottom this text). In addition, these findings have recently been recognised as one of the world's top 10 scientific breakthroughs of 2009 by Time magazine. See: http://www.time.com/time/specials/packages/article/0,28804,1945379_1944376_1944408,00.html Publications: Sky News Channel 4 News BBC Wales News ITV Wales Pittsburgh post - Gazette Daily Express Swansea Sound Washington Post New York Times Daily Telegraph Western Mail South Wales Echo The Independent The Irish Times Financial Times Sydney Morning Herald Ottawa Citizen Daily Mail Guardian The Mirror Nottingham Journal The Money Times The Sun Sindh Today Science Daily Belfast Telegraph Emax Health Malaysia News net Digital Journal Cambridge News Online Alzheimer's Society Real Radio Red Dragon Boston Globe Calgary Sun Norwich Evening News The Gov Monitor The Spokesman Review Food consumer Times of India Science News Medical News Today Top News NHS News Nature.com Blog Efitness.now Merinews Science Alert Pulse Today AHN Richmond Times - Dispatch The Birmingham News, Alabama Newsday, Melville NY The San Diego Union - Tribune, California El Nuevo Herald The Daily Gazette, New York St Paul's Pioneer Press Valley News Dispatch Chattanooga Times Free Press St Petersburg Times The Virginian - Pilot The Providence Journal The Gainsville Sun San Jose Mercury News The Journal Gazette Daily Times - Call The Tribune Visit Bulgaria Australian Ageing Agenda The News - Enterprise Ethiopian Review The Times - Tribune, PA South Florida Sun Sentinel ABC7 St Charles County Business Record The St Louis Countian Such extensive media coverage has raised the profile of Alzheimer's disease and dementia research. Since the articles were published we have received numerous enquiries from members of the public wanting to contribute to our research. It has also promoted our own research nationally and internationally and we have developed collaborations as a direct result of this media coverage. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Health and Care Research Wales Public Engagement talk 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Institute of Psychological Medicine and Clinical Neurosciences staff at Cardiff University School of Medicine were required to attend a one hour presentation on the importance of engaging with the public in scientific research. The aim was to give staff a greater appreciation of public involvement, and the benefits of this in research. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.healthandcareresearch.gov.wales/involving-the-public-in-your-research |
| Description | ITV Wales - DRI interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor Julie Williams from the Dementia Research Institute and Dr Claudia Metzler-Baddeley and Umesh Rudrapatna from CUBRIC were featured on Wales This Week: Memory Matters (ITV Wales) |
| Year(s) Of Engagement Activity | 2018 |
| Description | ITV Wales interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with James Crichton-Smith at ITV Wales - ITV Wales are running a piece on early onset Alzheimers. |
| Year(s) Of Engagement Activity | 2015 |
| Description | ITV Wales interview Dec. 2015 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with James Crichton-Smith at ITV Wales - ITV Wales are running a piece on early onset Alzheimers. |
| Year(s) Of Engagement Activity | 2015 |
| Description | IWA's Agenda magazine |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Professor Julie Williams' Alzheimer's research is featured in the summer edition of IWA's Agenda magazine (Agenda, No 41 Agenda, Front Page and Pgs 48-49) Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | Interview for national news |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview on national TV which is broadcast worldwide describing set up of Cardiff Univ receiving funding to set up as a UK dementia centre |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.bbc.co.uk/news/uk-wales-south-east-wales-39646667 |
| Description | Interview for national news |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Official opening of UK DRI Cardiff, attended by 300+ guests, including funders, Welsh government officials, members of the public taking part in dementia research studies, postgraduates. Widely publicised on national BBC and ITV news and radio |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.bbc.co.uk/news/uk-wales-45942094 |
| Description | Interview for regional news |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview on regional news to discuss setting up of new DRI UK laboratories in Cardiff and work on dementia research |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.itv.com/news/wales/2017-04-20/dementia-centre-to-offer-step-change-in-research/ |
| Description | Interview with ITV news |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Julie Williams was interviewed by ITV news in the HEB labs regarding Alzheimer's disease research |
| Year(s) Of Engagement Activity | 2015 |
| Description | It is time to make mental health research a funding priority |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Professor Julie Williams, School of Medicine, argues in an essay that it is time to make mental health research a funding priority. Cardiff University has committed to this in creating the new Neuroscience and Mental Health Research Institute - and Professor Williams calls on other decision makers and funders to do likewise. (W.Mail, 9.8.10 p26) Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | Keynote speech Sutcliffe Kerr Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Keynote speech at annual Walton Centre, Sutcliffe Kerr Lecture |
| Year(s) Of Engagement Activity | 2019 |
| Description | Kings College London Seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | Delivered talk entitled - Psychiatric Genetics: Everything you always wanted to know but were afraid to ask Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | Llandough Hospital |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Health professionals |
| Results and Impact | Dissemination of recent findings not known |
| Year(s) Of Engagement Activity | 2009 |
| Description | Local news item on brain donation for dementia research |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Older people in Wales are being urged to think about donating their brains after they die to help scientists researching dementia. This has sparked questions and debates - 80 comments within 24 hours. It will definitely influence people by raising awareness of the disease, the process of donation, benefits of donation/research and also opting in/out law change. We are confident this will increase the number of healthy/diseased donations and positively impact research field. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.bbc.co.uk/news/uk-wales-43084710 |
| Description | MRC CNGG/NCMH/CADR stand at the Wales Gene park's Genetics and Genomics Conference |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Representatives from the Alzheimer's Genetics Team manned a stand at the Wales Gene Park's Genetics and Genomics Conference on 22nd June, 2016. A number of individuals were interested in discussing the research environment, and how participants could help with discovery science. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.eventbrite.co.uk/e/genetics-and-genomics-for-the-3rd-generation-tickets-24871582573 |
| Description | Marshall Scholars |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | A talk entitled "New genetic findings in Alzheimers Disease" was presented to a group of Marshall Scholars not known |
| Year(s) Of Engagement Activity | 2010 |
| Description | Medical Women's Federation Spring Conference 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on 'Finding the causes of Alzheimer's disease' |
| Year(s) Of Engagement Activity | 2018 |
| Description | NGFN Symposium - Bonn |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Delivered talk entitled - Molecular Genetics in Alzheimer's Dementia Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | New Alzheimer's genes revealed |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Two potentially key genes linked to the development of Alzheimer's disease have been uncovered by UK researchers. Covered by major news channels including the BBC Nationwide media coverage will lead to increased public knowledge |
| Year(s) Of Engagement Activity | 2010 |
| Description | New susceptibility genes for Alzheimer's disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Invited speaker - Eisai Symposium in Neuroscience (Dementia and Cognitive Dysfunction) - May 2010 Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | Oxford Seminar Series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | Invited speaker - Seminar Series,University of Oxford - June 2010 Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | Plenary Speaker at the Alzheimer's Association International Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The plenary speech described our scientific advances in gene discovery and AD risk prediction. This reached an audience of several thousand researchers, clinicians, families, policy makers and funders in the dementia area. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation and Questions at Carers Group. Participant = Alun Meggy (AD Team) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Carers attend weekly groups that cover a variety or topics about dementia. We were invited to talk about research. The group organiser asked for a further talk in the future |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation and Questions at Torfaen Carers Centre. Participants = Alun Meggy, Jack Beaumont (AD Team) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Study participants or study members |
| Results and Impact | People with dementia and their carers/ families attended a talk to understand why research is important in the field of dementia |
| Year(s) Of Engagement Activity | 2017 |
| Description | Public Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | We hosted a public meeting, supported by the Alzheimer's Research Trust, in September 2007. In addition to events hosted within the University we have also presented our research findings to carers, and individuals with AD at Alzheimer's Society regional meetings in Cardiff, Swansea, Blackwood and Caerleon and to the members of the Newport Carers Group and County Hosptial Carers Group, Pontypool. These meetings contribute substantially to engaging the public in our research. |
| Year(s) Of Engagement Activity | 2007 |
| Description | Quote for This is Wales publication |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Quotation provided on the subject of innovation in Wales for trade magazine, emphasising research focus on dementia, specifically Alzheimer's disease |
| Year(s) Of Engagement Activity | 2018 |
| Description | Radio Cymru Discussion on Alzheimer's disease. Participant = Alun Meggy, AD Team |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Mr Alun Meggy took part in a Welsh discussion group broadcast live on Radio Cymru on 17th February 2017. Alun spoke in Welsh regarding Alzhiemer's disease research, and how we are working hard to develop our knowledge of this debilitating disease. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Recorded interview ARUK conference March 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | An interview with Video Journal Dementia at ARUK Conference 2018 discussing work at Cardiff DRI UK - online publication aimed at healthcare professionals |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://vjdementia.com/speaker/julie-williams |
| Description | Researchers Find Two More Genetic Risk Factors For Alzheimer's Disease |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Widespread worldwide broadcast, press and online coverage of a major new study into Alzheimer's led by researchers at Cardiff University. Including BBC, Channel 4, SKY and ABC news, The Telegraph, The Times, The Telegraph, The New York Times and all over major news channels / papers. "The MRC Centre and research like this is changing our understanding of what causes the common form of Alzheimer's disease and provides valuable new leads in the race to find treatments and possibly cures. "It also shows that other genes can be identified using this method, and we are already planning a larger study involving 60,000 people, which can be achieved within the next year. "It is also important to recognise the contribution many Welsh people who have acted as subjects for this research over the years." |
| Year(s) Of Engagement Activity | 2009,2010 |
| Description | SciScreen Dementia Event |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Rebecca Sims gave a public presentation on Dementia research before a free screening of the film "Away from Her", post-film discussion and free drinks reception. The purpose of the event is for scientists to engage with the general public for mutual benefit. The presentation was well received, and the discussions were lively. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Science Cafe talk 10th May 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | A talk was given by PhD student and Neurologist, Dr Jude Harrison. Science Cafe events are designed to encourage the general public to engage with science in an informal environment. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Scientists at Cardiff University say they are a step closer to understanding the causes of dementia |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Scientists at Cardiff University say they are a step closer to understanding the causes of dementia, thanks to a grant of nearly £250,000. The money will fund its brain bank, a centre which encourages people to donate their brains for medical research. Professor Julie Williams comments (BBC Wales On-line, 04.07.2013 Unknown |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.bbc.co.uk/news/uk-wales-22288025 |
| Description | Tenby Observer |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk by Prof Julie Williams (at Oriel y Parc, 5 Aug) advertised |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.tenby-today.co.uk/article.cfm?id=105748&headline=Oriel%20y%20Parc%20to%20host%20second%20... |
| Description | The International Genomics of Alzheimer's Project (IGAP) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A leading University expert in identifying genes that cause Alzheimer's disease will meet with some of the world's other figures for the first-time in Paris (Friday 19th November) in a bid help share knowledge and speed-up the genetic fight against the disease. The International Genomics of Alzheimer's Project (IGAP) is a major international consortium which brings together for the first time four of the world's leading research centres - including Professor Julie Williams, School of Medicine, who leads the Genetic and Environmental Risk in Alzheimer's Disease (GERAD). Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | The Today Programme |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | JW on BBC Radio 4's Today programme talking about her discovery of two new genes associated with Alzheimer's disease which could provide valuable new leads in the race to find treatments and possibly cures for the devastating condition Unknown |
| Year(s) Of Engagement Activity | 2009 |
| Description | Time Magazine - Medical breakthroughs of 2009 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A key University study which helped uncover two new genes associated with Alzheimer's disease has been recognised as one of the top 10 medical breakthroughs of 2009 by TIME Magazine. International acknowledgement of research findings. |
| Year(s) Of Engagement Activity | 2009 |
| Description | U3A Brecon |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Dissemination of Alzheimers research findings not known |
| Year(s) Of Engagement Activity | 2010 |
| Description | UN Older Persons Day - Cardiff |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Delivered talk entitled - Will identifying susceptibility genes for Alzheimer's Disease increase healthy aging? Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | WAG Seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presented recent research findings to policy makers not known |
| Year(s) Of Engagement Activity | 2010 |
| Description | Welsh language champions in NHS health boards |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Professor Julie Williams, School of Medicine comments on plans to appoint Welsh language champions in NHS health boards. (Western Mail, 7/6/10, p25) Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | Welsh presentation (Cardiff Science Society) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | A presentation was given in Welsh, by Alzheimer's Field Worker, Alun Meggy to the Cardiff Science Society on 21st November 2016. This was followed by questions and a discussion. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.cymdeithaswyddonolcaerdydd.org |
| Description | Westminster visit - Dementia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Dissemination of research findings to parliamentarians not known |
| Year(s) Of Engagement Activity | 2009 |
| Description | Will identifying susceptibility genes for Alzheimer's disease increase healthy ageing? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited speaker - United Nations Older Person's Day - Promoting active and healthy ageing - Cardiff, 30th September 2010 Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | Will members of my family develop Alzheimers disease?' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Rebecca Sims presented "Will members of my family develop Alzheimer's disease?" at CADR Meeting Swansea, 2/8/2018. This reached an audience of 50 persons including general public, medical professionals, researchers and carers. This generated a number of questions and discussion after the talk, and was part of a wider discussion following other presentations focusing on similar topics. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Young Onset Dementia: Different impact, positive solutions conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | This public meeting was held on 27th September, 2016. This was a recruitment opportunity. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.youngdementiauk.org/sites/default/files/Young%20Dementia%202016%20programme.pdf |
| Description | Zeurs Austria - Drugs Genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presented talk entitled - Defining the genetic architecture for AD not known |
| Year(s) Of Engagement Activity | 2009 |
| Description | alt.Cardiff blog entry |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Journalist Jessica Phillips interviews Julie Williams for an article on her blog |
| Year(s) Of Engagement Activity | 2015 |