The regulation of imprinted genes by non-coding RNAs

Lead Research Organisation: University of Cambridge
Department Name: Anatomy

Abstract

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Publications

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Edwards CA (2007) Mechanisms regulating imprinted genes in clusters. in Current opinion in cell biology

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Ferguson-Smith AC (2007) Epigenetics: perceptive enzymes. in Nature

 
Description 086838/Z/08/Z (Functional genomics of an imprinted domain: an integrated model for the epigenetic control of genome function)
Amount £677,000 (GBP)
Funding ID 086838/Z/08/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2009 
End 12/2012
 
Description Air non-coding RNA 
Organisation Babraham Institute
Country United Kingdom 
Sector Private 
PI Contribution Thp genetic mouse mutants, matings and some dissection
Collaborator Contribution 18988810
Impact 18988810
Start Year 2008
 
Description Dr Martina Paulsen in Germany 
Organisation Saarland University
Country Germany 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution Dr Martina Paulsen in Germany (ex postdoc funded on previous MRC grant) to determine higher resolution analysis of the domains and the extent of the noncoding RNA transcripts in the intergenic regions. This resulted in one publication.
Impact NA
 
Description Prof Michel Georges (Liege) and Dr Jerome Cavaille in Toulouse 
Organisation University of Liege
Country Belgium 
Sector Academic/University 
PI Contribution We identified additional multiple maternally expressed microRNAs at the locus in collaboration with Prof Michel Georges (Liege) and Dr Jerome Cavaille in Toulouse, and showed that they functioned in an RNAi dependent pathway to regulate on of the mRNA genes expressed from the paternally inherited chromosome.
Impact This resulted in two publications.
 
Description Prof Michel Georges (Liege) and Dr Jerome Cavaille in Toulouse 
Organisation University of Toulouse
Department Department of Molecular Biology
Country France 
Sector Academic/University 
PI Contribution We identified additional multiple maternally expressed microRNAs at the locus in collaboration with Prof Michel Georges (Liege) and Dr Jerome Cavaille in Toulouse, and showed that they functioned in an RNAi dependent pathway to regulate on of the mRNA genes expressed from the paternally inherited chromosome.
Impact This resulted in two publications.
 
Description Prof Roger Pedersen in Cambridge 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution Prof Roger Pedersen in Cambridge to determine the epigenetic status of the locus in human ES cells. This resulted in three publications and a collaborative grant for future work.
Impact NA
 
Description Prof Tom Ogata in Japan 
Organisation Tokyo Medical and Dental University
Country Japan 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution Prof Tom Ogata in Japan to determine the importance of the genes and non-coding transcripts at this domain in human disease syndromes. This resulted in one publication.
Impact NA
 
Description Prof Tomohiro Kono in Japan 
Organisation Tokyo University of Agriculture
Department Nodai Research Institute
Country Japan 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution Prof Tomohiro Kono in Japan to assess the contribution of genes and non-coding RNAs at the locus in determining the failure of parthenogenetic conceptuses. This resulted in three publications.
Impact NA