Lipotoxicity, a common patogenic mechanism of the Metabolic Syndrome

Lead Research Organisation: University of Cambridge
Department Name: Clinical Biochemist

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Huang-Doran I (2017) Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease. in Trends in endocrinology and metabolism: TEM

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Lage R (2008) AMPK: a metabolic gauge regulating whole-body energy homeostasis. in Trends in molecular medicine

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López M (2007) Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intake. in BioEssays : news and reviews in molecular, cellular and developmental biology

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López M (2008) Brain lipogenesis and regulation of energy metabolism. in Current opinion in clinical nutrition and metabolic care

 
Description Organisation of conferences/Courses
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact It is expected these training schemes have contributed to better care and scientifc developments. Member of the Scientific Organising Committee 1. Cambridge, United Kingdom. 30th June - 2nd July 2015. EAS Advanced Course in Cardiometabolic Phenotyping in Rodents. 2. Boston, USA. 5th - 9th June 2015. ADA Scientific Sessions Insulin Action/Molecular Metabolism. 3. Colorado, USA. 9th - 13th February 2015. Keystone Symposia - Systems Biology of Lipid Metabolism. 4. Madrid, Spain. 7th - 8th November 2014. CNIC Conference "Energy homeostasis and metabolic disease". 5. Madrid, Spain. 7th-8th November 2014. Energy homeostasis and metabolic disease. CNIC. 6. Cambridge, UK. 30th September 2014. 14th Annual Cambridge Immunology Forum Meeting. • Member of the Scientific Organising Committee Keystone meeting on Nuclear receptors. (http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=1235?Tab=travel) Austria (2013) • Member of the Scientific Organising Committee 15th European Congress of Endocrinology 27th April - 1st May 2013. Copenhagen, Denmark (http://www.ece2013.org/committees.aspx) • Director of The European Atherosclerosis Society Advanced Course IV: Murine Genetics and Cardiometabolic Phenotyping 11th - 14th July 2012. Cambridge, United Kingdom (http://www.eas-society.org/advanced-course-iv,-cambridge.aspx • Member of the Organising Scientific Committee of The Royal Society and Academy of Medical Sciences symposium on "Brown adipose tissue: a new human organ?" London (2012) (http://www.physoc.org/me2012) • Member of the Organising Scientific Committee The Obese Species Workshop Sicily, Italy. 21st - 26th October (2011) http://theobesespecies.unipr.it/. • Member of the Organising Scientific Committee for the meeting of the EAS in Hamburg. Germany (2010) • Member of the Organising Scientific Committee of the 49th International Conference on the Bioscience of Lipids. Maastrich (2008)
 
Description • International Scientific Advisory Board Danish Academy of Diabetes (2018-)
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact • International Scientific Advisory Board Danish Academy of Diabetes (2018-) Advice on training and research priorities.
URL https://www.danishdiabetesacademy.dk/news/dda-appoints-strong-new-international-advisory-board
 
Description BBSRC Project Grant (The role of wnt signalling network in adipose tissue development and plasticity)
Amount £379,685 (GBP)
Funding ID BB/E011950/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2007 
End 02/2009
 
Description BHF Project Grant
Amount £145,520 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2008 
End 12/2009
 
Description HEPADIP (11.7m euros across 24 participants)
Amount £1,500,000 (GBP)
Funding ID 18734 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 03/2005 
End 02/2010
 
Description MRC Programme Grant
Amount £1,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2009 
End 06/2013
 
Description MRC Translational Research Grant (Metabolic and cardiovascular Disease)
Amount £665,546 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2009 
End 02/2010
 
Description NIH RO1
Amount $3,000,000 (USD)
Funding ID R01DK107786 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2017 
End 06/2021
 
Title Development of methodology for microarray and lipidomic analysis 
Description We have contributed to develop methods for lipid analysis 
Type Of Material Technology assay or reagent 
Year Produced 2007 
Provided To Others? Yes  
Impact 1) Oresic M, H?nninen VA, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers.Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23PMID: 18951641 2)Tang J, Tan CY, Oresic M, Vidal-Puig A. Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med. 2009 Mar 30;1(3):35. [Epub ahead of print] PMID: 19341506 3) Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M. Informatics and computational strategies for the study of lipids.Mol Biosyst. 2008 Feb;4(2):121-7. Epub 2007 Dec 18. Review. 4).Oresic M, Vidal-Puig A, H?nninen V.Metabolomic approaches to phenotype characterization and applications to complex diseases.Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. 
URL http://europepmc.org/abstract/MED/18951641
 
Title Development of the Phenomics center 
Description Development of three core facilities, a) Murine phenotyping, b) Murine Biochemistry and c) Murine Histopathology 
Type Of Material Improvements to research infrastructure 
Year Produced 2006 
Provided To Others? Yes  
Impact Development of MRC CORD murine metabolic programme Development and expansion vreating the Cambridge Phenomics centre. 
 
Title Differentiation of ES cells 
Description Protocols do differentiation of Human PSC to brown, white and macrophage phenotype 
Type Of Material Cell line 
Provided To Others? No  
Impact Competitiveness in our research and funding acquisition e.g. ERC grant 
 
Title Microarray/lipidomic data bases 
Description Microarray and lipidomic data form in vivo experiments using animal models 
Type Of Material Biological samples 
Year Produced 2007 
Provided To Others? Yes  
Impact This material has been utilised by other EU groups focused in modelling and development of tools for nutritional research 
 
Title Tools for data quatification 
Description LEM-PCR: a method for determining relative transcript isoform proportions using real-time PCR without a standard curve.Virtue S, Dale M, Sethi JK, Vidal-Puig A. Genome. 2010 Aug;53(8):637-42. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2010 
Provided To Others? Yes  
Impact Improved accuracy of data analysis 
 
Title Bionash 
Description Data base of human liver biopsies 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact Contribution to International consortiums such fp7 Epos and FP7 IMI LItmus 
URL http://www.epos-nafld.eu/
 
Description Brown fat 
Organisation The Wenner-Gren Institute
Department Phsyiology
Country Sweden 
Sector Academic/University 
PI Contribution We have developed a new area of research focused on BAT
Collaborator Contribution Knowledge and technology
Impact Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C, Burling K, Campbell M, Eguchi N, Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A. A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 61(12):3139-47 (2012).Virtue S, F.H., Christian M, Tan CY, Masoodi M, Dale M, et al (10 authors) Vidal-Puig A. Diabetes in press (2012), Virtue, S., M. Christian, C. Tan, M. Masoodi, M. Dale, ( 10 authors) A. Vidal-Puig, A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes (in press) 2012. Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85.
Start Year 2006
 
Description Flies as a disease model to study metabolic disease 
Organisation German Cancer Research Center
Country Germany 
Sector Public 
PI Contribution provide hypothesis for validation in flies and also perform experiments in mammalian systems with insights coming from flies.
Collaborator Contribution generation of genetically modified flies mimicking mouse or cell genetic modification.
Impact Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601. Dietary stearic acid regulates mitochondria in vivo in humans. Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA. Nat Commun. 2018 Aug 7;9(1):3129. doi: 10.1038/s41467-018-05614-6. PMID: 30087348 Free PMC Article
Start Year 2015
 
Description LPGD2S KO MOUSe 
Organisation Osaka University
Country Japan 
Sector Academic/University 
PI Contribution Phenotyping of mouse models
Collaborator Contribution provided animal models for MRC funded project.
Impact Papers still under submission expected to be published during 2010
Start Year 2007
 
Description Lipidomic technology 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Unit
Country United Kingdom 
Sector Public 
PI Contribution provided intellectual framework, experimental design and biological samples.
Collaborator Contribution Providing lipidomic analysis from biological samples.
Impact 1.Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. Epub 2009 Oct 19. PMID: 19841237 2.Tang J, Tan CY, Oresic M, Vidal-Puig A.Integrating post-genomic approaches as a strategy to advance our understanding of health and disease.Genome Med. 2009 Mar 30;1(3):35.PMID: 19341506 3.Oresic M, Hänninen VA, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23. PMID: 18951641 4.Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M.Informatics and computational strategies for the study of lipids. Mol Biosyst. 2008 Feb;4(2):121-7. PMID: 18213405 5.Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A.PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.PLoS Genet. 2007 Apr 27;3(4):e64. PMID: 17465682 6.Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M.Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis.BMC Syst Biol. 2007 Feb 15;1:12. PMID: 17408502 7.Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.PLoS Biol. 2006 Nov;4(11):e369.PMID: 17090215 8.Oresic M, Vidal-Puig A, Hänninen V. Metabolomic approaches to phenotype characterization and applications to complex diseases.Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. PMID: 16824031 15. Virtue S, F.H., Christian M, Tan CY, Masoodi M, Dale M, et al (10 authors) Vidal-Puig A. Diabetes in press (2012), A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes, (2012.) Virtue, S., M. Christian, C. Tan, M. Masoodi, M. Dale, C. ( 10 authors) A. Vidal-Puig, A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 2012. Griffin, J.L. and A. Vidal-Puig, Current challenges in metabolomics for diabetes research: a vital functional genomic tool or just a ploy for gaining funding? Physiol Genomics, 2008. 34(1): p. 1-5. Pietilainen, K.H., T. Rog, T. Seppanen-Laakso, S. Virtue, P. Gopalacharyulu, J.(16 authors), A. Vidal-Puig, and M. Oresic, Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol, 2011. 9(6): p. e1000623. 19. Prieur, X., C.Y. Mok, V.R. Velagapudi, V. Nunez, L. Fuentes, D. (9 authors), A. Vidal-Puig, Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 2011. 60(3): p. 797-809. 20. Kilpelainen, T.O., M.C. Zillikens, A. Stancakova, F.M. Finucane, J.S. Ried, C. Langenberg, (65 authors) A. Vidal-Puig, (40 authors) R.J. Loos, Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet, 2011. 43(8): p. 753-60. 21. Medina-Gomez, G., L. Yetukuri, V. Velagapudi, M. Campbell, M. Blount,et al (3 authors), A. Vidal-Puig, Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech, 2009. 2(11-12): p. 582-92. 22. Vivas, Y., C. Martinez-Garcia, A. Izquierdo, F. Garcia-Garcia, S. Callejas, (4 authors), A. Vidal-Puig, and G. Medina-Gomez, Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. BMC Med Genomics, 2012. 4: p. 86. Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C, Burling K, Campbell M, Eguchi N, Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A. A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 61(12):3139-47 (2012). 4. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes 2013 Aug 6. [Epub ahead of print] 12. Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešic M, Urade Y, Griffin JL, Vidal-Puig A. Lipocalin Prostaglandin D Synthase and PPAR?2 Coordinate to Regulate Carbohydrate and Lipid Metabolism In Vivo. PLoS One 7(7):e39512. (2012) Rodriguez-Cuenca S, Carobbio S, Velagapudi VR, Barbarroja N, Moreno-Navarrete JM, Tinahones FJ, Fernandez-Real JM, Oresic M, Vidal-Puig A. PPAR? DEPENDENT REGULATION OF LIPOLYTIC NODES AND METABOLIC FLEXIBILITY. Moll Cell Biol. 2012 Feb 6.
Start Year 2006
 
Description Lipidomic technology 
Organisation Technical Research Centre of Finland (VTT)
Department Matej Oresic VTT
Country Finland 
Sector Academic/University 
PI Contribution provided intellectual framework, experimental design and biological samples.
Collaborator Contribution Providing lipidomic analysis from biological samples.
Impact 1.Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. Epub 2009 Oct 19. PMID: 19841237 2.Tang J, Tan CY, Oresic M, Vidal-Puig A.Integrating post-genomic approaches as a strategy to advance our understanding of health and disease.Genome Med. 2009 Mar 30;1(3):35.PMID: 19341506 3.Oresic M, Hänninen VA, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23. PMID: 18951641 4.Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M.Informatics and computational strategies for the study of lipids. Mol Biosyst. 2008 Feb;4(2):121-7. PMID: 18213405 5.Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A.PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.PLoS Genet. 2007 Apr 27;3(4):e64. PMID: 17465682 6.Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M.Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis.BMC Syst Biol. 2007 Feb 15;1:12. PMID: 17408502 7.Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.PLoS Biol. 2006 Nov;4(11):e369.PMID: 17090215 8.Oresic M, Vidal-Puig A, Hänninen V. Metabolomic approaches to phenotype characterization and applications to complex diseases.Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. PMID: 16824031 15. Virtue S, F.H., Christian M, Tan CY, Masoodi M, Dale M, et al (10 authors) Vidal-Puig A. Diabetes in press (2012), A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes, (2012.) Virtue, S., M. Christian, C. Tan, M. Masoodi, M. Dale, C. ( 10 authors) A. Vidal-Puig, A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 2012. Griffin, J.L. and A. Vidal-Puig, Current challenges in metabolomics for diabetes research: a vital functional genomic tool or just a ploy for gaining funding? Physiol Genomics, 2008. 34(1): p. 1-5. Pietilainen, K.H., T. Rog, T. Seppanen-Laakso, S. Virtue, P. Gopalacharyulu, J.(16 authors), A. Vidal-Puig, and M. Oresic, Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol, 2011. 9(6): p. e1000623. 19. Prieur, X., C.Y. Mok, V.R. Velagapudi, V. Nunez, L. Fuentes, D. (9 authors), A. Vidal-Puig, Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 2011. 60(3): p. 797-809. 20. Kilpelainen, T.O., M.C. Zillikens, A. Stancakova, F.M. Finucane, J.S. Ried, C. Langenberg, (65 authors) A. Vidal-Puig, (40 authors) R.J. Loos, Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet, 2011. 43(8): p. 753-60. 21. Medina-Gomez, G., L. Yetukuri, V. Velagapudi, M. Campbell, M. Blount,et al (3 authors), A. Vidal-Puig, Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech, 2009. 2(11-12): p. 582-92. 22. Vivas, Y., C. Martinez-Garcia, A. Izquierdo, F. Garcia-Garcia, S. Callejas, (4 authors), A. Vidal-Puig, and G. Medina-Gomez, Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. BMC Med Genomics, 2012. 4: p. 86. Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C, Burling K, Campbell M, Eguchi N, Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A. A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 61(12):3139-47 (2012). 4. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes 2013 Aug 6. [Epub ahead of print] 12. Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešic M, Urade Y, Griffin JL, Vidal-Puig A. Lipocalin Prostaglandin D Synthase and PPAR?2 Coordinate to Regulate Carbohydrate and Lipid Metabolism In Vivo. PLoS One 7(7):e39512. (2012) Rodriguez-Cuenca S, Carobbio S, Velagapudi VR, Barbarroja N, Moreno-Navarrete JM, Tinahones FJ, Fernandez-Real JM, Oresic M, Vidal-Puig A. PPAR? DEPENDENT REGULATION OF LIPOLYTIC NODES AND METABOLIC FLEXIBILITY. Moll Cell Biol. 2012 Feb 6.
Start Year 2006
 
Description Molecular mechanisms of mitochondrial biogenesis 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution Provided biological samples for platform development
Collaborator Contribution Providing animal models generated by AZaccess to lipidomic platforms
Impact Integration in FP7 Etherpath grant
Start Year 2008
 
Description Molecular mechanisms of mitochondrial biogenesis 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Provided biological samples for platform development
Collaborator Contribution Providing animal models generated by AZaccess to lipidomic platforms
Impact Integration in FP7 Etherpath grant
Start Year 2008
 
Description Molecular mechanisms of mitochondrial biogenesis 
Organisation Zora Biosciences Oy
Country Finland 
Sector Private 
PI Contribution Provided biological samples for platform development
Collaborator Contribution Providing animal models generated by AZaccess to lipidomic platforms
Impact Integration in FP7 Etherpath grant
Start Year 2008
 
Title Development of New equipment for mouse phenotyping. 
Description Improved equipment for simultaneous measurement of food intake, energy expnditure, activity, drinking behaviour. 
Type Support Tool - For Fundamental Research
Current Stage Of Development Initial development
Year Development Stage Completed 2009
Development Status Actively seeking support
Impact In the process of trying to get patent. 
 
Description Bilbao, Spain. 1st March 2017. Seminar at Biofisika, Basque Centre for Biophysics. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Bilbao, Spain. 1st March 2017. Seminar at Biofisika, Basque Centre for Biophysics. Lecture. Networking with engineers.
Year(s) Of Engagement Activity 2017
URL http://biofisika.org/
 
Description Dusseldorf, Germany. 10th October 2017. Universitäts Klinikum Lecture Series - CRC1116 "master switches after myocardial infarction" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dusseldorf, Germany. 10th October 2017. Universitäts Klinikum Lecture Series - CRC1116 "master switches after myocardial infarction"
Year(s) Of Engagement Activity 2017
URL http://www.irtg1902.hhu.de/schedule/schedule-single-view.html?tx_cal_controller%5Bgetdate%5D=2017101...
 
Description Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Keystone Conference Lecture. Colorado, USA. 22nd - 27th January 2017.
Year(s) Of Engagement Activity 2017
URL http://healthdocbox.com/amp/69735120-Diabetes/Diabetes-january-22-26-2017-keystone-conference-center...
 
Description Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact . Colorado, USA. 22nd - 27th January 2017. Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology.
Year(s) Of Engagement Activity 2016
 
Description Lisbon, Portugal. 11th-15th September 2017. 53rd EASD Annual Meeting. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lisbon, Portugal. 11th-15th September 2017. 53rd EASD Annual Meeting. >150 attendants to symposium on Obesity associated metabolic complications.
Year(s) Of Engagement Activity 2017
URL https://d-net.idf.org/en/events/369-53rd-easd-annual-meeting-in-lisbon-portugal.html
 
Description Majorca, Spain. 16th October 2017. Seminar at Illes Balears Institute for Health Research. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Majorca, Spain. 16th October 2017. Seminar at Illes Balears Institute for Health Research. Research seminar. >80 attendees.
Year(s) Of Engagement Activity 2017
URL https://www.arabalears.cat/balears/Antonio-Vidal-Puig-nostres-estalviadors-lluitar_0_1892210855.html
 
Description Mexico. 13th-14th February 2019. Nutrition Forum 2019 Danone Institute of Mexico. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on obesity and nutrition
Year(s) Of Engagement Activity 2018
URL https://www.danoneinstitute.org/nutrition-health/local-initiatives
 
Description Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). Lecture on the Adipose tissue expandability, lipotoxicity and metabolic syndrome.
Year(s) Of Engagement Activity 2018
 
Description Vienna, Austria. 15th-19th October 2016. UEG Week. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 2. Vienna, Austria. 15th-19th October 2016. UEG Week. Main meeting on gastroenterology in Europe.
Year(s) Of Engagement Activity 2016
 
Description Vienna, Austria. 2nd February 2018. Seminar at Vienna Biocenter 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Vienna, Austria. 2nd February 2018. Seminar at Vienna Biocenter. Lecture to postcs in this institute and meetings with specific students to discuss their projects
Year(s) Of Engagement Activity 2018
URL https://cluster.meduniwien.ac.at/index.php?id=3732&tx_ttnews%5Btt_news%5D=3280&tx_ttnews%5Bpointer%5...
 
Description World Forum on Scientific & Technological Innovation in London. Looking for solutions to the emerging epidemic of ageing related health problems in China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Highlights from the World Forum on Scientific & Technological Innovation in London. Looking for solutions to the emerging epidemic of ageing related health problems in China
Year(s) Of Engagement Activity 2018
URL https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity...
 
Description Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. Role of lipidomics in metabolic research
Opening keynote lecture
Antonio Vidal-Puig (University of Cambridge, UK)
"Adipose tissue expandability, lipotoxicity and the metabolic syndrome"
Year(s) Of Engagement Activity 2018
URL https://www.oru.se/english/about-us/conferences/nordic-metabolomics-conference/program/
 
Description . Cambridge, UK. 11th April 2016. British Heart Foundation Cardiovascular Research Excellence Annual Event. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact 4. Cambridge, UK. 11th April 2016. British Heart Foundation Cardiovascular Research Excellence Annual Event.
Year(s) Of Engagement Activity 2016
 
Description . London, UK. 11th January 2017. Seminar at the MRC Clinical Sciences Centre, Imperial College London. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact . London, UK. 11th January 2017. Seminar at the MRC Clinical Sciences Centre, Imperial College London.
Year(s) Of Engagement Activity 2016
 
Description 23/01/2017 Invited Talk, Meeting "Bile Acids, Nuclear Receptors and Nutrition" (Metabolic Control of Liver Regeneration and Hepatocellular Carcinogenesis: Nuclear Receptors and Beyond), University Medical Centre Utrecht, NL 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 23/01/2017 Invited Talk, Meeting "Bile Acids, Nuclear Receptors and Nutrition" (Metabolic Control of Liver Regeneration and Hepatocellular Carcinogenesis: Nuclear Receptors and Beyond), University Medical Centre Utrecht, NL
Year(s) Of Engagement Activity 2017
 
Description 28/07/2017 Faculty Speaker, NEEDPRO Summer School in Applied Human Nutrition (Diet and Fatty Liver: A Case Study), Cambridge, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 28/07/2017 Faculty Speaker, NEEDPRO Summer School in Applied Human Nutrition (Diet and Fatty Liver: A Case Study), Cambridge, UK This is an annual summer course on Nutrition
Year(s) Of Engagement Activity 2017
 
Description 29/06/2017 Faculty Speaker, University Rey Juan Carlos (URJC) Summer School for University students and Working Professionals (Molecular basis of NASH development and progression; lipids and beyond). Madrid, ES 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 29/06/2017 Faculty Speaker, University Rey Juan Carlos (URJC) Summer School for University students and Working Professionals (Molecular basis of NASH development and progression; lipids and beyond). Madrid, ES
Year(s) Of Engagement Activity 2017
 
Description 3. Tsukuba, Japan. 17th-19th September 2016. Tsukuba Global Science Week. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Tsukuba, Japan. 17th-19th September 2016. Tsukuba Global Science Week.
Year(s) Of Engagement Activity 2016
 
Description 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK).
Year(s) Of Engagement Activity 2018
URL https://www.eventbrite.co.uk/e/v-christmas-seminar-science-of-healthy-diet-sports-wellbeing-tickets-...
 
Description 5. London, UK. 30th October 2018. California Walnut Commission Scientific & Health Research Meeting. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 5. London, UK. 30th October 2018. California Walnut Commission Scientific & Health Research Meeting.
Year(s) Of Engagement Activity 2018
URL https://www.bighospitality.co.uk/News/Promotional-Features/California-Walnut-Culinary-Institute-of-A...
 
Description ADA 2016. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact New Orleans, USA. 10th - 14th June 2016. American Diabetes Association's Scientific Session's 76th Scientific Sessions.
Year(s) Of Engagement Activity 2016
 
Description Barcelona, Spain. 24th-25th November 2017. AstraZeneca - Diabetter: The implications of the adipocyte in T2D 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Barcelona, Spain. 24th-25th November 2017. AstraZeneca - Diabetter: The implications of the adipocyte in T2D. Symposia organised by Astra Zeneca addressed to Spanish Endocrinologists
Year(s) Of Engagement Activity 2017
 
Description Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2. Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life.
Year(s) Of Engagement Activity 2018
URL https://www.basellife.org/basel-life-2018.html
 
Description Bilbao, Spain. 8th June 2018. Seminar at Biogune. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 7. Bilbao, Spain. 8th June 2018. Seminar at Biogune.
Year(s) Of Engagement Activity 2018
URL https://twitter.com/CICbioGUNE
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk
 
Description Blog BAT 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events
 
Description Cambridge Metabolic Network/Danish Diabetes Association Course for PhD Students. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Course sponsored by NOVO foundation from Denmark, 35 PhD students from Cambridge and Denmark.
Year(s) Of Engagement Activity 2017
URL https://www.danishdiabetesacademy.dk/events/lipid-metabolism-new-methods-and-translational-aspects
 
Description Cambridge, United Kingdom. 2nd November 2017. Cardio-metabolic meeting for Early Career Researchers 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Cambridge, United Kingdom. 2nd November 2017. Cardio-metabolic meeting for Early Career Researchers. This is a meeting organised by the Junior scientists directed to promote networking and exchange
Year(s) Of Engagement Activity 2017
URL http://www.metabolism.cam.ac.uk/event/cardiometabolic-early-career-researchers-event-encouraging-col...
 
Description Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Edmonton, Canada. 2nd May 2016. Distinguished Speaker Lecture, University of Alberta. !50 approx. students and post docts attended lecture.
Year(s) Of Engagement Activity 2016
 
Description EPOS2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Wehosted the 2020 Horizon EPoS project Steering commitee meeting at St Catherine College in Cambridge to discuss the latest results on the pathogenesis, diagnostic and treatment of fatty liver and NASH.
Year(s) Of Engagement Activity 2019
URL https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity...
 
Description Form the future Careers Carousel at Sawston Village College 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Form the future Careers Carousel at Sawston Village College
Year(s) Of Engagement Activity 2017
 
Description Geneva, Switzerland. 23rd January 2018. Symposium: Neuroendocrine regulation of metabolism and dysfunctions in obesity/type 2 diabetes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Geneva, Switzerland. 23rd January 2018. Symposium: Neuroendocrine regulation of metabolism and dysfunctions in obesity/type 2 diabetes
Year(s) Of Engagement Activity 2018
URL http://www.unige.ch/medecine/diabetescentre/fr/actualites/sym/
 
Description Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium.
Year(s) Of Engagement Activity 2018
 
Description Harrogate, United Kingdom. 6th-8th November 2017. Society for Endocrinology BES Conference. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Harrogate, United Kingdom. 6th-8th November 2017. Society for Endocrinology BES Conference. Lecture related to Medal award.
Year(s) Of Engagement Activity 2017
URL https://www.endocrinology.org/events/sfe-bes-conference/sfe-bes-2017/
 
Description Heidelberg, Germany. 12th May 2016. Seminar at German Cancer Research Center (DKFZ) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Heidelberg, Germany. 12th May 2016. Seminar at German Cancer Research Center (DKFZ)
Year(s) Of Engagement Activity 2016
 
Description Lisbon, Portugal. 21st-23rd May 2017. Aegerion ECE Symposium. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lisbon, Portugal. 21st-23rd May 2017. Aegerion ECE Symposium. This was a symposia with clear clinical translational implications addressed to practitioners that had implications on their practice.
Year(s) Of Engagement Activity 2017
URL http://www.ece2017.org/media/1123/ece-2017-satellite-programmes_280317.pdf
 
Description MIddle EaSt obesity 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Professors Toni Vidal-Puig MD PhD FRCP FMedSci EMBA and Meis Moukayed have honoured us by writing the fascinating article, People with obesity: Their heroic battle to defeat their genes in a hostile hypercaloric sedentary environment. The professors explain why more than 50 human genes, the environment and lifestyle culture all contribute to why it is not so easy as the doctor telling the patient to lose weight. In addition to looking at the 'why' of obesity,
Year(s) Of Engagement Activity 2018
URL https://www.middleeastmedicalportal.com/product/november-december-2018/
 
Description Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium.
Year(s) Of Engagement Activity 2018
URL https://www.ciberobn.es/en
 
Description Malaga, Spain. 19th - 21st October 2016. Congress of the Spanish Society of Endocrinology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Malaga, Spain. 19th - 21st October 2016. Congress of the Spanish Society of Endocrinology
Year(s) Of Engagement Activity 2016
 
Description Malaga, Spain. 20th-23rd March 2017. Danish Diabetes Academy Postdoc Winter School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact On March 19-24, 2017, a total of 99 Post Doc fellows, third-year PhD students and prominent national and international speakers attended Danish Diabetes Academy's 3rd Winter School in Malaga with focus on different aspects of prevention and treatment of diabetes as well as career development. Malaga, Spain. 20th-23rd March 2017. Danish Diabetes Academy Postdoc Winter School. .
Year(s) Of Engagement Activity 2017
URL https://www.danishdiabetesacademy.dk/node/1087
 
Description Members of the TVP lab recently attended the 1st ICAN conference series in Cardiometabolic Disease in Paris. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact TVP Lab members give presentations and posters at 1st ICAN conference series in Cardiometabolic Disease

Members of the TVP lab recently attended the 1st ICAN conference series in Cardiometabolic Disease in Paris. Vanessa Pellegrinelli was selected to give a presentation, and Camilla Ingvorsen, Guillaume Bidault, and Vivian Peirce were selected to present posters. Vivian Peirce was a joint-winner of Young Investigator poster award.



Projection of our lab
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Mexico Instituto Zubiran de Nutricion 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Seminar evaluation PhD students projects
Year(s) Of Engagement Activity 2019
URL https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity...
 
Description Nanjing, China. 8th May 2017. Lecture at Nanjing Biomedical Research Institute. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Nanjing, China. 8th May 2017. Lecture at Nanjing Biomedical Research Institute. Talk at this institute in China in front of > 100 students.
Year(s) Of Engagement Activity 2017
 
Description Oxford, UK. 18th January 2019. Seminar in Department of Physiology, Anatomy & Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Oxford, UK. 18th January 2019. Seminar in Department of Physiology, Anatomy & Genetics
Date: 18 January 2019, 13:00 (Friday, 1st week, Hilary 2019)
Venue:
Sherrington Building
off Parks Road OX1 3PT
See location on maps.ox

Details: Large Lecture Theatre
Speaker: Professor Antonio Vidal-Puig (University of Cambridge)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser contact email address: ana.domingos@dpag.ox.ac.uk
Host: Dr Ana Domingos (University of Oxford, DPAG)
Part of: DPAG Head of Department Seminar Series
Topics: Inflammation, Diabetes, Adipose tissues, Metabolic syndrome, Obesity
Year(s) Of Engagement Activity 2018
URL https://new.talks.ox.ac.uk/talks/id/f6ae26ed-6a85-4ea6-8236-0be648588540/
 
Description Paris, France. 11th-15th April 2018. EASL International Liver Congress. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at the Paris, France. 11th-15th April 2018. EASL International Liver Congress focused on the pathogenesis of fatty liver and the effect of Lipotoxicty
Year(s) Of Engagement Activity 2018
URL https://easl.eu/discover/events/detail/2018/the-international-liver-congress-2018
 
Description Prof Vidal-Puig. radio Interview EITB Basque Country 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact http://www.eitb.com/es/audios/detalle/841034/audio-obesos-saludables-anillamiento-aves-nuevas-tecnologias/

Prof. Vidal-Puig discussed for the EITB radio (Basque country, Spain) the impact of the environmental factors contributing to the obesity pandemic in the last half century; the concepts of adipose tissue expandability and the paradox of the "healthy obese" as well as the possibility of developing new strategies aimed to increase energy expenditure to fight against obesity and associated metabolic diseases.
Year(s) Of Engagement Activity 2012
 
Description Royal Swedish Academy of Sciences, Journal of Internal Medicine - Key Symposium "Metabolic complications of obesity" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Organisation of symposia with 150 attendants, 28 speakers from EU, USA, JAPAN, CHINA. Top symposium supported by the Swedish Academy of Sciences and the Journal of Internal Medicine.
Year(s) Of Engagement Activity 2017
URL http://www.mrl.ims.cam.ac.uk/event/metabolic-complications-obesity/
 
Description Science News Study inMice suggests drug to turn fat brown could help fight obesity 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact https://www.sciencedaily.com/releases/2018/11/181126123416.htm
Study in mice suggests drug to turn fat 'brown' could help fight obesity
Date:November 26, 2018 Source:University of Cambridge Summary:Our bodies contain two types of fat: white fat and brown fat. While white fat stores calories, brown fat burns energy and could help us lose weight. Now, scientists have found a way of making the white fat 'browner' and increasing the efficiency of brown fat. While their study was carried out in mice, they hope that this finding will translate into humans and provide a potential new drug to help fight obesity.
Year(s) Of Engagement Activity 2018
URL https://www.sciencedaily.com/releases/2018/11/181126123416.htm
 
Description Southern Furen, Denmark 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Schools
Results and Impact Teaching to PhD students from Denmark

Disseminating Science and attracting some of these excellent student to post doctoral training in UK.
Year(s) Of Engagement Activity 2009
 
Description Toulouse, France. 28th April 2017. Seminar at INSERM. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Toulouse, France. 28th April 2017. Seminar at INSERM. Dissemination of research outcomes to research commnity
Year(s) Of Engagement Activity 2017
URL https://www.stromalab.fr/actualites/pr-toni-vidal-puig-university-of-cambridge-uk/
 
Description Tye 2 Diabetes; Atherapeutic avenue is emerging 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Date:December 5, 2018 Source:INSERM (Institut national de la santé et de la recherche médicale) Summary:Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers are developing a therapeutic strategy that uses the properties of an enzyme (hormone-sensitive lipase) which, when stimulating fatty-acid synthesis in the fat cells, has a beneficial effect on insulin action.
Year(s) Of Engagement Activity 2018
URL https://www.sciencedaily.com/releases/2018/12/181205134014.htm
 
Description University of Santiago (Spain) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Teaching science to undergraduates

Extend the impact of UK research abroad.
Year(s) Of Engagement Activity 2008
 
Description https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283
November 27, 2018
Could this be a solution for the obesity crisis?
Samuel Virtue, University of Cambridge; Antonio Vidal-Puig, University of Cambridge, and Vanessa Pellegrinelli, University of Cambridge
Scientists manage to boost brown fat in mice with a molecule called BMP8b. Could this be the future for treating obesity?
Year(s) Of Engagement Activity 2018
URL https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283
 
Description wide audience publishing 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Publication in Journals without impact factor for general publisc with interest in science.

Communicating science to young individuals
Year(s) Of Engagement Activity 2008,2009