The modulation of catecholamine-thiol adduct-induced neuronal injury by flavonoids and their metabolites

Lead Research Organisation: University of Reading
Department Name: Food and Nutritional Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Pollard SE (2006) The reaction of flavonoid metabolites with peroxynitrite. in Biochemical and biophysical research communications

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Spencer JP (2008) Flavonoids: modulators of brain function? in The British journal of nutrition

 
Description Diet and Brain Health
Geographic Reach Asia 
Policy Influence Type Influenced training of practitioners or researchers
Impact Greater underdtanding of the influence of flavonoids and brain health and fruit and vegetable intake and prevention of brain disease.
 
Description Alpro Foundation Grant
Amount £150,000 (GBP)
Organisation Alpro Foundation 
Sector Charity/Non Profit
Country Belgium
Start 02/2010 
End 01/2012
 
Description BBSRC DRINC research grant 2008
Amount £367,234 (GBP)
Funding ID BB/G005702/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2008 
End 03/2011
 
Description BBSRC Research Grant 2008
Amount £485,357 (GBP)
Funding ID BB/F008953/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2008 
End 06/2011
 
Description European Union 7th Framework research grant
Amount £366,000 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 07/2009 
End 06/2012
 
Description Mars Nutrition Research Council funding
Amount £86,000 (GBP)
Organisation Mars Nutrition Research Council, Mars Incorporated 
Sector Private
Country United States
Start 08/2008 
End 06/2011
 
Title Cell culture facillity 
Description Dedicated room for cell culture work 
Type Of Material Improvements to research infrastructure 
Year Produced 2008 
Provided To Others? Yes  
Impact Cell biology research has been advanced 
 
Title Flavonoid metabolites 
Description metabolites for use in studying the effects of flavonoids on cells 
Type Of Material Biological samples 
Year Produced 2009 
Provided To Others? Yes  
Impact More physiologically relevant flavonoid studies and papers 
 
Description The effects of Champagne wine consumption on brain health 
Organisation Comité Interprofessionnel du Vin de Champagne (CIVIC)
Country France 
Sector Charity/Non Profit 
PI Contribution Wrote proposals and hosted PhD students
Collaborator Contribution Two Partly funded PhD studentships. Further expands the flavonoid/brain and vascular research programme.
Impact Partly funded PhD studentship. Further expands the flavonoid/brain research programme.
Start Year 2006
 
Description The effects of flavanols on brain and vascular health 
Organisation Mars Incorporated UK
Country United Kingdom 
Sector Private 
PI Contribution Wrote successful grant application and hosted PhD student
Collaborator Contribution Supply of research intervention diets for human clinical trial (£60,000). Fully funded PhD studenship (stipend + fees + runing costs). Enhances my groups work in the flavonoid vascular area.
Impact Greatly expands the flavonoid brain and vascular research programme.
Start Year 2007
 
Description 3rd International Conference on Polyphenols and Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact International conference; 40 min oral presentation

Press release and round table discussions.
Year(s) Of Engagement Activity 2009
 
Description 3rd International Congress on Wine and Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact International conference; 30 min oral presentation

Press release
Year(s) Of Engagement Activity 2008
 
Description 3rd International Congress on Wine and Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact International conference; 20 min oral presentation

Conference press release and individual interviews. French media interest
Year(s) Of Engagement Activity 2008
 
Description Annual Congress Oxidants and Antioxidants in Biology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact International conference; 15 min oral presentation

Collaboration
Year(s) Of Engagement Activity 2007
 
Description BBC2 Gardeners World programme on Superfoods 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Filming at the University and Interviews for broadcast

Interest from the general public, NHS hospitals and private care homes.
Year(s) Of Engagement Activity 2008
 
Description Diet and Brain Health Film 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Recorded and film for the University of Reading regarding the research area. ~15 min and published on the Universities website

Increased recruitment. Increased Industrial funding.
Year(s) Of Engagement Activity 2010
 
Description Fourth European Nutrigenomics Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact European Conference; 20 min oral presentation

Press release for conference and media interest
Year(s) Of Engagement Activity 2008
 
Description Mars Nutrition Research Council 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Industrial Conferenece; 40 min oral presentation

Funding directed towards this research in 2007, 2008 and 2009.
Year(s) Of Engagement Activity 2007
 
Description Oxygen Club California 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact International conference; 45 min oral presentation

Press conference and discussion regarding future research focus in the area.
Year(s) Of Engagement Activity 2009
 
Description Oxygen Club of California 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact International conference; 30 min oral presentation.

media interest in the USA
Year(s) Of Engagement Activity 2007
 
Description Royal Pharmaceutical Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact International conference; 45 min oral presentation

Press release and media interviews
Year(s) Of Engagement Activity 2009
 
Description Science Museum's Dana Centre 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact public event venue for contemporary science debate.

Press conference leading to interviews with The Times, The Observer, The Daily Mail and The Wine Spectator about some of the MRC research outputs. 1h show on Superfoods which aired on BBC2 in August 2007. Interviews with Channel 4 News and BBC radio. The MRC was referred to as funder where possible.
Year(s) Of Engagement Activity 2007
 
Description Scirus Topic Pages 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Design of website

more public awareness of the research area
Year(s) Of Engagement Activity 2012
 
Description Sixth Form Summer School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact organisation and running of the laboratory sessions as part of the School of Food Biosciences 'Sixth Form Open Day'. This course gives A-level students a chance to experience the academic research environment. Experiments related to this MRC grant were used in order to show how certain nutrients may be beneficial to human brain health. June 2005, 2006, 2007 and 2008

Increased recruitment of students.
Year(s) Of Engagement Activity
 
Description Society for Free Radical Research-International 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact International conference; 30 min oral presentation

Media interest
Year(s) Of Engagement Activity 2007
 
Description TV Programme 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Part of a TV programme 'The Food Hospital". Filmed a piece relating to the MRC funded research.

A number of schools have requested lay talks to pupils.
Year(s) Of Engagement Activity 2014
 
Description TV Programme 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Part of TV programme "Britain's Favourite Supermarket Foods". Filmed a section for this programme on the MRC funded research.

Further media interest and school presentations
Year(s) Of Engagement Activity 2012
 
Description The Nutrition Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact International conference; 30 min oral presentation

Press release and significant media interest. Collaborations made and grants applied for.
Year(s) Of Engagement Activity 2008
 
Description The Times, The Observer, The Daily Mail and The Wine Spectator 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Edited Interviews for publication, mainly 2007 and 2008

Interest from the general public and NHS
Year(s) Of Engagement Activity 2009
 
Description The Wye Valley School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Talk to 6th-form students about University level science and research.

Increased recruitment and interest in science in general.
Year(s) Of Engagement Activity 2012
 
Description Third European Nutrigenomics Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact European conference; 20 min oral presentation

Conference press release and media interest
Year(s) Of Engagement Activity 2007
 
Description Website articles - Various 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Usually telephone interviews followed by publication of edited interview on public websites.

Interest from the general public usually by email
Year(s) Of Engagement Activity