A prototype of a bacterial mitotic spindle: moving DNA molecules apart through a polymerization-based engine

Lead Research Organisation: University of York
Department Name: Biology

Abstract

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Publications

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Barillà D (2007) The tail of the ParG DNA segregation protein remodels ParF polymers and enhances ATP hydrolysis via an arginine finger-like motif. in Proceedings of the National Academy of Sciences of the United States of America

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Derome A (2008) Centromere anatomy in the multidrug-resistant pathogen Enterococcus faecium. in Proceedings of the National Academy of Sciences of the United States of America

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Fothergill TJ (2005) Protein diversity confers specificity in plasmid segregation. in Journal of bacteriology

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Hayes F (2006) Assembling the bacterial segrosome. in Trends in biochemical sciences

 
Description Project Grant
Amount £447,649 (GBP)
Funding ID G0801162 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2009 
End 06/2012
 
Title A collection of TP228 plasmid segregation mutants 
Description A number of mutants impaired in the segregation of the TP228 multidrug resistance plasmids were constructed. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Provided To Others? No  
Impact The constructions of these mutants allowed us to shed light on the mechanism of segregation of the TP228 multidrug resistance plasmid. 
 
Description Finbarr Hayes - Genome segregation mechanisms 
Organisation University of Manchester
Department Manchester Interdisciplinary Biocentre
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing crucial reagents (DNA clones), providing expertise on specialised techniques, intellectual input to design projects and training of staff.
Collaborator Contribution The research sinergy betweeen my collaborator's group and my group resulted in the publication of a number of high profile papers.
Impact A number of significant publications: 16415929 16584885 17261809 17920627 18245388
Start Year 2006
 
Description BA Festival of Science, University of York 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Poster on our work on multidrug resistance bacteria directed to a lay audience

I guess disseminating our work in front of a lay audience.
Year(s) Of Engagement Activity 2007
 
Description EMBO Meeting on Bacterial Cytoskeletal Structures, Copenhagen August 2006 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Poster presentation, ~150 people attended this meeting.

Establishment of new collaborations
Year(s) Of Engagement Activity 2006
 
Description Invited talk (University of Leeds) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact I gave a talk on the recently published work on the stimulation of ParF ATPase activity by ParG.

I guess it promoted my research to colleagues in another university.
Year(s) Of Engagement Activity 2007
 
Description Plasmid Biology 2008 Conference (Gdansk, Poland) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Poster presentation

Disseminating the data generated through my research
Year(s) Of Engagement Activity 2008
 
Description Tromso Meeting on Antibiotic Resistance 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Talk/Poster presentation

Learning more about antibiotic resistance.
Year(s) Of Engagement Activity 2007
 
Description UCAS days for undergraduate recruitment 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Talk to perspective undergraduate students

Trying to enthuse the next generation of microbiologits.
Year(s) Of Engagement Activity 2007,2008,2009,2010,2011,2012