The role of endothelium in regulating stem cell homing to the liver
Lead Research Organisation:
University of Birmingham
Department Name: Clinical and Experimental Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Palmer DH
(2009)
A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma.
in Hepatology (Baltimore, Md.)
Fletcher NF
(2014)
Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner.
in Hepatology (Baltimore, Md.)
Lalor PF
(2007)
Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion.
in Hepatology (Baltimore, Md.)
Crosby HA
(2009)
Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.
in Journal of hepatology
Marttila-Ichihara F
(2017)
Amine oxidase activity regulates the development of pulmonary fibrosis.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Karim S
(2013)
An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells.
in Toxicological sciences : an official journal of the Society of Toxicology
Jeffery HC
(2019)
Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases.
in Journal of immunology (Baltimore, Md. : 1950)
Parker R
(2018)
CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease.
in American journal of physiology. Gastrointestinal and liver physiology
Miles A
(2008)
CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow.
in American journal of physiology. Gastrointestinal and liver physiology
Wadkin JCR
(2017)
CD151 supports VCAM-1-mediated lymphocyte adhesion to liver endothelium and is upregulated in chronic liver disease and hepatocellular carcinoma.
in American journal of physiology. Gastrointestinal and liver physiology
Weston CJ
(2013)
Cellular localization and trafficking of vascular adhesion protein-1 as revealed by an N-terminal GFP fusion protein.
in Journal of neural transmission (Vienna, Austria : 1996)
Jeffery HC
(2018)
Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis.
in Hepatology communications
Trivedi PJ
(2018)
Chemokines and Chemokine Receptors as Therapeutic Targets in Inflammatory Bowel Disease; Pitfalls and Promise.
in Journal of Crohn's & colitis
Trivedi PJ
(2018)
Chemokines and Chemokine Receptors as Therapeutic Targets in Inflammatory Bowel Disease; Pitfalls and Promise.
in Journal of Crohn's & colitis
Heydtmann M
(2009)
Chemokines in the immunopathogenesis of hepatitis C infection.
in Hepatology (Baltimore, Md.)
Shetty S
(2011)
Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium.
in Journal of immunology (Baltimore, Md. : 1950)
Adams DH
(2018)
Could endothelial TGFß signaling be a promising new target for liver disease?
in Expert review of gastroenterology & hepatology
Aspinall AI
(2010)
CX(3)CR1 and vascular adhesion protein-1-dependent recruitment of CD16(+) monocytes across human liver sinusoidal endothelium.
in Hepatology (Baltimore, Md.)
Oo YH
(2012)
CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver.
in Journal of hepatology
Dufton NP
(2017)
Dynamic regulation of canonical TGFß signalling by endothelial transcription factor ERG protects from liver fibrogenesis.
in Nature communications
Karim S
(2014)
Dysregulated hepatic expression of glucose transporters in chronic disease: contribution of semicarbazide-sensitive amine oxidase to hepatic glucose uptake.
in American journal of physiology. Gastrointestinal and liver physiology
Than NN
(2019)
Efficacy of rituximab in difficult-to-manage autoimmune hepatitis: Results from the International Autoimmune Hepatitis Group.
in JHEP reports : innovation in hepatology
Ward ST
(2014)
Evaluation of serum lysyl oxidase as a blood test for colorectal cancer.
in European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Chauhan A
(2018)
Exercise alters the hepatic immunophenotype to protect against inflammatory liver disease.
in Hepatology (Baltimore, Md.)
Weston CJ
(2011)
Hepatic consequences of vascular adhesion protein-1 expression.
in Journal of neural transmission (Vienna, Austria : 1996)
Lalor PF
(2013)
Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment.
in American journal of physiology. Gastrointestinal and liver physiology
Davies SP
(2019)
Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4 T Cell Engulfment Process.
in Cell reports
Lalor PF
(2006)
Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo.
in World journal of gastroenterology
Patten DA
(2017)
Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: A new step in migration.
in Hepatology (Baltimore, Md.)
Resheq YJ
(2017)
Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13.
in Journal of immunology (Baltimore, Md. : 1950)
Chen YY
(2019)
Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis.
in JHEP reports : innovation in hepatology
Oo YH
(2019)
Liver homing of clinical grade Tregs after therapeutic infusion in patients with autoimmune hepatitis.
in JHEP reports : innovation in hepatology
Jeffery HC
(2017)
Low-dose interleukin-2 promotes STAT-5 phosphorylation, T survival and CTLA-4-dependent function in autoimmune liver diseases.
in Clinical and experimental immunology
Shetty S
(2008)
Lymphocyte recruitment to the liver: molecular insights into the pathogenesis of liver injury and hepatitis.
in Toxicology
Adams DH
(2010)
Mechanisms of immune-mediated liver injury.
in Toxicological sciences : an official journal of the Society of Toxicology
Triantafyllou E
(2018)
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure.
in Gut
Liaskou E
(2013)
Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics.
in Hepatology (Baltimore, Md.)
Trivedi PJ
(2013)
Mucosal immunity in liver autoimmunity: a comprehensive review.
in Journal of autoimmunity
De Graaf KL
(2018)
NI-0801, an anti-chemokine (C-X-C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid.
in Hepatology communications
Lutz P
(2019)
NK Cells in Ascites From Liver Disease Patients Display a Particular Phenotype and Take Part in Antibacterial Immune Response.
in Frontiers in immunology
Rowe IA
(2014)
Paracrine signals from liver sinusoidal endothelium regulate hepatitis C virus replication.
in Hepatology (Baltimore, Md.)
Malehmir M
(2019)
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer.
in Nature medicine
Chauhan A
(2017)
Platelets Are Critical Drivers of Illness Behaviors During Liver Inflammation.
in Gastroenterology
Hirschfield GM
(2013)
Primary sclerosing cholangitis.
in Lancet (London, England)
Liaskou E
(2011)
Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity.
in Hepatology (Baltimore, Md.)
Oo YH
(2012)
Regulatory T cells and autoimmune hepatitis: defective cells or a hostile environment?
in Journal of hepatology
| Description | NIHR BRU in Cell and Immunotherapy for LIver disease |
| Amount | £6,500,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Birmingham Liver Biomedical Research Unit |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2008 |
| End | 09/2012 |
| Description | Edinburgh |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Inflammation Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have developed a successful local collaboration with my colleague Dr Newsome andPorfs Forbes and Iredale in Edinburgh resulting an ongoing collaboration which ahs contributed to a recent MRC grant awarded in 2009. |
| Collaborator Contribution | We have several ongoing collaborations sharing technology and expertise |
| Impact | Ongoing publications and research collaborations |
| Start Year | 2008 |
| Description | Guardian |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | -Article in the Guardian on liver disease and transplantation www.guardian.co.uk/society/2008/nov/28/organ-donation-health-policy-transplant Incraesed public profile |
| Year(s) Of Engagement Activity | 2008 |
| Description | PPI initiatve |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | 20 members of the public and patients attended a seminar/workshop on liver research in Birmingham Panel agreed to review our research patient information sheets |
| Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014 |
| Description | PSC |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Hosted meeting of the PSC patient group to discuss our research Took on role as Trustee of the Charity in 2013 Asked to host the meeting on an annual basis Helped develop a research funding programme for the charity Helped write guieldlines and provide clinical advice |
| Year(s) Of Engagement Activity | 2009,2010,2011,2012,2013,2014 |
| URL | http://www.pscsupport.org.uk/?gclid=Cj0KEQiAp4yjBRCE_enjmpug944BEiQATCpLvU1wXwOybMo7BSFeWs_AEICLJAiy... |
| Description | Public engagement |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | PSC Trust meeting London Discussion of the potential for stem cell therapy in liver disease. A funding initiative to support genomics in liver disease. |
| Year(s) Of Engagement Activity | 2007 |
| Description | Schools |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | -Students from local schools come to the department to learn about research and to carry out short projects Goldcrest award and Nuffield Bursary award |
| Year(s) Of Engagement Activity | 2007,2008,2009,2010,2011,2012,2013,2014,2015 |
| Description | World hepatitis day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | -Hosted public meeting for World hepatitis day attended by patient groups, politicians, press. Featured on Kerrang Radio & Naked scientist website http://www.thenakedscientists.com/HTML/podcasts/specials/show/2009.06.10/ Increased profile |
| Year(s) Of Engagement Activity | 2009 |