The role of endothelium in regulating stem cell homing to the liver
Lead Research Organisation:
University of Birmingham
Department Name: Clinical and Experimental Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
De Graaf KL
(2018)
NI-0801, an anti-chemokine (C-X-C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid.
in Hepatology communications
Dufton NP
(2017)
Dynamic regulation of canonical TGFß signalling by endothelial transcription factor ERG protects from liver fibrogenesis.
in Nature communications
Fletcher NF
(2014)
Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner.
in Hepatology (Baltimore, Md.)
Heydtmann M
(2009)
Chemokines in the immunopathogenesis of hepatitis C infection.
in Hepatology (Baltimore, Md.)
Hirschfield GM
(2013)
Primary sclerosing cholangitis.
in Lancet (London, England)
Jeffery HC
(2018)
Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis.
in Hepatology communications
Jeffery HC
(2017)
Low-dose interleukin-2 promotes STAT-5 phosphorylation, T survival and CTLA-4-dependent function in autoimmune liver diseases.
in Clinical and experimental immunology
Jeffery HC
(2019)
Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases.
in Journal of immunology (Baltimore, Md. : 1950)
Karim S
(2013)
An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells.
in Toxicological sciences : an official journal of the Society of Toxicology
| Description | NIHR BRU in Cell and Immunotherapy for LIver disease |
| Amount | £6,500,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Birmingham Liver Biomedical Research Unit |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2008 |
| End | 09/2012 |
| Description | Edinburgh |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Inflammation Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have developed a successful local collaboration with my colleague Dr Newsome andPorfs Forbes and Iredale in Edinburgh resulting an ongoing collaboration which ahs contributed to a recent MRC grant awarded in 2009. |
| Collaborator Contribution | We have several ongoing collaborations sharing technology and expertise |
| Impact | Ongoing publications and research collaborations |
| Start Year | 2008 |
| Description | Guardian |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | -Article in the Guardian on liver disease and transplantation www.guardian.co.uk/society/2008/nov/28/organ-donation-health-policy-transplant Incraesed public profile |
| Year(s) Of Engagement Activity | 2008 |
| Description | PPI initiatve |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | 20 members of the public and patients attended a seminar/workshop on liver research in Birmingham Panel agreed to review our research patient information sheets |
| Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014 |
| Description | PSC |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Hosted meeting of the PSC patient group to discuss our research Took on role as Trustee of the Charity in 2013 Asked to host the meeting on an annual basis Helped develop a research funding programme for the charity Helped write guieldlines and provide clinical advice |
| Year(s) Of Engagement Activity | 2009,2010,2011,2012,2013,2014 |
| URL | http://www.pscsupport.org.uk/?gclid=Cj0KEQiAp4yjBRCE_enjmpug944BEiQATCpLvU1wXwOybMo7BSFeWs_AEICLJAiy... |
| Description | Public engagement |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | PSC Trust meeting London Discussion of the potential for stem cell therapy in liver disease. A funding initiative to support genomics in liver disease. |
| Year(s) Of Engagement Activity | 2007 |
| Description | Schools |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | -Students from local schools come to the department to learn about research and to carry out short projects Goldcrest award and Nuffield Bursary award |
| Year(s) Of Engagement Activity | 2007,2008,2009,2010,2011,2012,2013,2014,2015 |
| Description | World hepatitis day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | -Hosted public meeting for World hepatitis day attended by patient groups, politicians, press. Featured on Kerrang Radio & Naked scientist website http://www.thenakedscientists.com/HTML/podcasts/specials/show/2009.06.10/ Increased profile |
| Year(s) Of Engagement Activity | 2009 |