The role of endothelium in regulating stem cell homing to the liver
Lead Research Organisation:
University of Birmingham
Department Name: Clinical and Experimental Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Miles A
(2008)
CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow.
in American journal of physiology. Gastrointestinal and liver physiology
Marttila-Ichihara F
(2017)
Amine oxidase activity regulates the development of pulmonary fibrosis.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Malehmir M
(2019)
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer.
in Nature medicine
Lutz P
(2019)
NK Cells in Ascites From Liver Disease Patients Display a Particular Phenotype and Take Part in Antibacterial Immune Response.
in Frontiers in immunology
Liaskou E
(2013)
Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics.
in Hepatology (Baltimore, Md.)
Liaskou E
(2011)
Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity.
in Hepatology (Baltimore, Md.)
Lalor PF
(2006)
Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo.
in World journal of gastroenterology
Lalor PF
(2013)
Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment.
in American journal of physiology. Gastrointestinal and liver physiology
Lalor PF
(2007)
Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion.
in Hepatology (Baltimore, Md.)
Lalor PF
(2007)
Vascular adhesion protein-1 as a potential therapeutic target in liver disease.
in Annals of the New York Academy of Sciences
King A
(2017)
Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.
in Gastroenterology
Karim S
(2014)
Dysregulated hepatic expression of glucose transporters in chronic disease: contribution of semicarbazide-sensitive amine oxidase to hepatic glucose uptake.
in American journal of physiology. Gastrointestinal and liver physiology
Karim S
(2013)
An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells.
in Toxicological sciences : an official journal of the Society of Toxicology
Jeffery HC
(2017)
Low-dose interleukin-2 promotes STAT-5 phosphorylation, T survival and CTLA-4-dependent function in autoimmune liver diseases.
in Clinical and experimental immunology
Jeffery HC
(2018)
Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis.
in Hepatology communications
Jeffery HC
(2019)
Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases.
in Journal of immunology (Baltimore, Md. : 1950)
Hirschfield GM
(2013)
Primary sclerosing cholangitis.
in Lancet (London, England)
Heydtmann M
(2009)
Chemokines in the immunopathogenesis of hepatitis C infection.
in Hepatology (Baltimore, Md.)
Fletcher NF
(2014)
Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner.
in Hepatology (Baltimore, Md.)
Dufton NP
(2017)
Dynamic regulation of canonical TGFß signalling by endothelial transcription factor ERG protects from liver fibrogenesis.
in Nature communications
De Graaf KL
(2018)
NI-0801, an anti-chemokine (C-X-C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid.
in Hepatology communications
Davies SP
(2019)
Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4 T Cell Engulfment Process.
in Cell reports
Crosby HA
(2009)
Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.
in Journal of hepatology
| Description | NIHR BRU in Cell and Immunotherapy for LIver disease |
| Amount | £6,500,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Birmingham Liver Biomedical Research Unit |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2008 |
| End | 09/2012 |
| Description | Edinburgh |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Inflammation Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have developed a successful local collaboration with my colleague Dr Newsome andPorfs Forbes and Iredale in Edinburgh resulting an ongoing collaboration which ahs contributed to a recent MRC grant awarded in 2009. |
| Collaborator Contribution | We have several ongoing collaborations sharing technology and expertise |
| Impact | Ongoing publications and research collaborations |
| Start Year | 2008 |
| Description | Guardian |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | -Article in the Guardian on liver disease and transplantation www.guardian.co.uk/society/2008/nov/28/organ-donation-health-policy-transplant Incraesed public profile |
| Year(s) Of Engagement Activity | 2008 |
| Description | PPI initiatve |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | 20 members of the public and patients attended a seminar/workshop on liver research in Birmingham Panel agreed to review our research patient information sheets |
| Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014 |
| Description | PSC |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Hosted meeting of the PSC patient group to discuss our research Took on role as Trustee of the Charity in 2013 Asked to host the meeting on an annual basis Helped develop a research funding programme for the charity Helped write guieldlines and provide clinical advice |
| Year(s) Of Engagement Activity | 2009,2010,2011,2012,2013,2014 |
| URL | http://www.pscsupport.org.uk/?gclid=Cj0KEQiAp4yjBRCE_enjmpug944BEiQATCpLvU1wXwOybMo7BSFeWs_AEICLJAiy... |
| Description | Public engagement |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | PSC Trust meeting London Discussion of the potential for stem cell therapy in liver disease. A funding initiative to support genomics in liver disease. |
| Year(s) Of Engagement Activity | 2007 |
| Description | Schools |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | -Students from local schools come to the department to learn about research and to carry out short projects Goldcrest award and Nuffield Bursary award |
| Year(s) Of Engagement Activity | 2007,2008,2009,2010,2011,2012,2013,2014,2015 |
| Description | World hepatitis day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | -Hosted public meeting for World hepatitis day attended by patient groups, politicians, press. Featured on Kerrang Radio & Naked scientist website http://www.thenakedscientists.com/HTML/podcasts/specials/show/2009.06.10/ Increased profile |
| Year(s) Of Engagement Activity | 2009 |