Neuropathological Substrates of Dementia after Stroke
Lead Research Organisation:
Newcastle University
Department Name: Institute for Ageing and Health
Abstract
Dementia is a major health problem which is increasing with the rising numbers of older people. Research effort in this field has focused largely on mechanisms that damage nerve-cells in disorders such as Alzheimer?s disease. Recent evidence suggests that impairments in blood supply to the brain may cause or accelerate these so-called ?neurodegenerative changes?. We have shown that 10% of patients who survive a stroke without severe memory problems, develop dementia in the following year. We have also highlighted possible risk associated with rapid changes in blood supply to the brain caused by disorders of cardiovascular regulation. The relationships between impaired blood supply, neurodegeneration and dementia are poorly understood. We propose to elucidate these, and identify the underlying mechanisms in older people who (a) have had a stroke and experience reduced blood supply to key subcortical regions of the brain. We will perform repeated clinical, psychological, cardiovascular and brain imaging assessments in these patients, to enable us to relate changes in memory and attention to structural damage to the brain. Most patients in our studies consent to brain donation at death, and we will compare pathological features with changes seen on brain imaging, and identify the molecular substrates of this damage. Our studies will advance understanding of the importance of how impariment occurs in stroke patients and in blood supply to the brain in dementia, and how this is affected by age. They will enable us to make more accurate, early diagnoses and identify those at risk of cognitive decline, and inform the development of therapies to slow or prevent such changes.
Our findings will be disseminated in many different ways, including: (i) publication in scientific journals; (ii) development of professional guidelines for the diagnosis and treatment of dementia and related medical conditions; (iii) inclusion in lay information bulletins and ?fact sheets? produced by bodies such as the Alzheimer?s Society, and US Alzheimer Association ;(iv) presentation at public lectures, workshops and carers support groups run by such organisations; and (v) through collaboration with Newcastle University?s Institute for Policy and Ethics in the Life Sciences (PEALS) whose main mission is to promote public engagement. Older people and representative voluntary organisations are involved in the strategic direction of research within the IAH and the management of facilities such as the brain tissue bank.
Our findings will be disseminated in many different ways, including: (i) publication in scientific journals; (ii) development of professional guidelines for the diagnosis and treatment of dementia and related medical conditions; (iii) inclusion in lay information bulletins and ?fact sheets? produced by bodies such as the Alzheimer?s Society, and US Alzheimer Association ;(iv) presentation at public lectures, workshops and carers support groups run by such organisations; and (v) through collaboration with Newcastle University?s Institute for Policy and Ethics in the Life Sciences (PEALS) whose main mission is to promote public engagement. Older people and representative voluntary organisations are involved in the strategic direction of research within the IAH and the management of facilities such as the brain tissue bank.
Technical Summary
Recent advances highlight the importance of vascular factors in the aetiopathogenesis of dementia but the relationships between vascular damage, cerebral hypoperfusion, neurodegenerative changes and cognitive decline remain unclear. We have previously shown (i) considerable overlap between Alzheimer?s disease and cerebrovascular disease, which is most pronounced in those aged over 80; (ii) 10% of older patients who survive a stroke without severe cognitive impairment at 3 months develop incident dementia in the first year; (iii) 30% of older stroke survivors show improvement in cognition over the first year; and (iv) a high proportion of patients with dementia have carotid sinus hypersensitivity (CSH) which correlates with the severity of small vessel disease.
Understanding the mechanisms for delayed dementia following stroke and the contribution of cerebral hypoperfusion to dementia, and the clinical characteristics which predict cognitive decline (or improvement) are essential if effective preventative strategies are to be developed. We will build upon our recent findings in post stroke dementia to address two key problems in a unique post-stroke cohort recruited and prospectively assessed during the last 5 years. Using pathological investigation of post-mortem specimens combined with in vivo imaging in post-stroke survivors, we will elucidate (i) whether cerebrovascular injury leads to increased burden of AD type changes in stroke survivors who become demented and (ii) whether increased burden of microvascular pathology in the subcortical structures (basal ganglia and thalamus) is a substrate for dementia in post-stroke survivors. Thus autopsy cases of post-stroke survivors will be examined for neuronal and microvascular pathology including Alzheimer lesions, cerebral amyloid angiopathy and hippocampal sclerosis and atrophy and subcortical WM pathology. To differentiate between post-stroke patients who decline and remain intact (improvers) we will also assess the expression of oxidative stress mechanisms in temporal lobe. Repeated assessments of clinical and neuropsychological measures prior to death will inform on the physical and cognitive status and be used to correlate with pathological findings and apolipoprotein E genotype. We believe the proposed research project will not only disclose the neuropathological substrates of post-stroke dementia but impact significantly on common dementing disorders in later life and underpin development of novel preventative and treatment strategies based on vascular protection.
Understanding the mechanisms for delayed dementia following stroke and the contribution of cerebral hypoperfusion to dementia, and the clinical characteristics which predict cognitive decline (or improvement) are essential if effective preventative strategies are to be developed. We will build upon our recent findings in post stroke dementia to address two key problems in a unique post-stroke cohort recruited and prospectively assessed during the last 5 years. Using pathological investigation of post-mortem specimens combined with in vivo imaging in post-stroke survivors, we will elucidate (i) whether cerebrovascular injury leads to increased burden of AD type changes in stroke survivors who become demented and (ii) whether increased burden of microvascular pathology in the subcortical structures (basal ganglia and thalamus) is a substrate for dementia in post-stroke survivors. Thus autopsy cases of post-stroke survivors will be examined for neuronal and microvascular pathology including Alzheimer lesions, cerebral amyloid angiopathy and hippocampal sclerosis and atrophy and subcortical WM pathology. To differentiate between post-stroke patients who decline and remain intact (improvers) we will also assess the expression of oxidative stress mechanisms in temporal lobe. Repeated assessments of clinical and neuropsychological measures prior to death will inform on the physical and cognitive status and be used to correlate with pathological findings and apolipoprotein E genotype. We believe the proposed research project will not only disclose the neuropathological substrates of post-stroke dementia but impact significantly on common dementing disorders in later life and underpin development of novel preventative and treatment strategies based on vascular protection.
Organisations
- Newcastle University, United Kingdom (Lead Research Organisation)
- Nanyang Technological University, Singapore (Collaboration)
- University of Southampton, United Kingdom (Collaboration)
- University College London, United Kingdom (Collaboration)
- University of Gothenburg, Sweden (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- University of Florence (Collaboration)
- University of Bristol, United Kingdom (Collaboration)
- University of Sydney, Australia (Collaboration)
- Stroke group Buck Institute (Collaboration)
- University of Glasgow, United Kingdom (Collaboration)
- University of Lille (Collaboration)
- Kyoto University, Japan (Collaboration)
- University of Exeter, United Kingdom (Collaboration)
- National Cerebral and Cardiovascular Centre (Collaboration)
- University of Helsinki, Finland (Collaboration)
- University of Sheffield, United Kingdom (Collaboration)
- National Institute for Longevity Sciences (NILS) (Collaboration)
- King's College London, United Kingdom (Collaboration)
Publications

Adav SS
(2014)
iTRAQ quantitative clinical proteomics revealed role of Na(+)K(+)-ATPase and its correlation with deamidation in vascular dementia.
in Journal of proteome research

Akinyemi RO
(2013)
Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia.
in Current Alzheimer research

Akinyemi RO
(2014)
Profile and determinants of vascular cognitive impairment in African stroke survivors: the CogFAST Nigeria Study.
in Journal of the neurological sciences

Akinyemi RO
(2017)
Hippocampal Neurodegenerative Pathology in Post-stroke Dementia Compared to Other Dementias and Aging Controls.
in Frontiers in neuroscience

Akinyemi RO
(2013)
Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia.
in Current Alzheimer research

Allan LM
(2013)
Long-term incidence of depression and predictors of depressive symptoms in older stroke survivors.
in The British journal of psychiatry : the journal of mental science

Allan LM
(2011)
Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors.
in Brain : a journal of neurology

Allan LM
(2007)
Autonomic dysfunction in dementia.
in Journal of neurology, neurosurgery, and psychiatry

Allan LM
(2009)
Incidence and prediction of falls in dementia: a prospective study in older people.
in PloS one

Banik A
(2015)
Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome?
in Journal of Alzheimer's disease : JAD
Description | DSM V criteria on vascular cognitive impairment |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a advisory committee |
Impact | This input to DSM committee will set new revised guidelines for diagnosis of dementia or cognitive function due to vascular disease. A manuscript resulting from these efforts has now been submitted for publication in Lancet Neurology (Sachdev P, Kalaria R et al, October 2011). |
Description | UK Dementia and Stroke Networks |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
Impact | UK plans to lead the criteria for Vascualar Dementia diagnosis |
Description | VCI Criteria Harmonisation- USA and Canada |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guideline committee |
Impact | Consensus guidelines and criteria for the diagnosis (clinical, radiological, neuropsychological and pathological) of Vascular Cognitive Impairment |
Description | VICCS Classifcation for vascular contributions to dementia |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
Description | ART Emergency Support |
Amount | £29,900 (GBP) |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2010 |
End | 12/2010 |
Description | ART PhD Studentship |
Amount | £88,000 (GBP) |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2009 |
End | 08/2012 |
Description | ART Pilot Project |
Amount | £150,000 (GBP) |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 10/2010 |
End | 09/2011 |
Description | ARUK Major Grant |
Amount | £435,000 (GBP) |
Funding ID | ARUK-PG2013-22 |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2013 |
End | 12/2017 |
Description | CADASIL Trust Research Fellowship |
Amount | £25,000 (GBP) |
Organisation | The CADASIL Research and Support Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2006 |
End | 12/2006 |
Description | Centre in Long Life Well Being Scheme, funded by BBSRC, EPSRC, ESRC and MRC |
Amount | £4,252,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2008 |
End | 10/2013 |
Description | DMT Research Project |
Amount | £250,000 (GBP) |
Funding ID | R2777/0213 |
Organisation | The Dunhill Medical Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2013 |
End | 12/2016 |
Description | IBRO International Fellowship |
Amount | £37,000 (GBP) |
Organisation | International Brain Research Organisation (IBRO) |
Sector | Academic/University |
Country | Global |
Start | 08/2009 |
End | 07/2011 |
Description | MRC Brain Banks Programme- UKCRC Brain Bank Strategy |
Amount | £250,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2011 |
End | 08/2013 |
Description | MRC Brain Banks Programme- UKCRC Brain Bank Strategy |
Amount | £374,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2011 |
End | 08/2013 |
Description | NIH R21 Research Project |
Amount | £150,000 (GBP) |
Organisation | National Institutes of Health (NIH) |
Sector | Public |
Country | United States |
Start | 07/2006 |
End | 06/2008 |
Description | Overseas Research Awards |
Amount | £35,000 (GBP) |
Organisation | Newcastle University |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2009 |
End | 08/2010 |
Description | Project Grant |
Amount | £250,000 (GBP) |
Organisation | The Dunhill Medical Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2007 |
End | 08/2009 |
Description | Project Grant |
Amount | £154,561 (GBP) |
Funding ID | AS-PG-17-007 |
Organisation | Alzheimer's Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2018 |
End | 12/2020 |
Description | Project Grant |
Amount | £561,607 (GBP) |
Funding ID | ARUK-PG2016B-6 |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 10/2016 |
Title | 3D Stereology technique to assess Neurons |
Description | Using post-mortem brain tissues from the post-stroke survivors cohort we have modified currently published methods to assess neuronal denisty and volumes by 3D stereology with light microscopy |
Type Of Material | Technology assay or reagent |
Provided To Others? | No |
Impact | Plan to publish the techinque as a new method. |
Title | Neuropsychological Profile for assessment of Post-Stroke Impairment |
Description | A database has been created to assess the neuropsychological profile and risk factors for post-stroke dementia |
Type Of Material | Database/Collection of Data/Biological Samples |
Provided To Others? | No |
Impact | Some of instruments arebeing used by a parallel study to assess post-stroke dementia in other population samples |
Description | Buck Institute for Age Research |
Organisation | Stroke group Buck Institute |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Sharing of reagents and brain tissue |
Impact | Manuscript for publication near completion (October 2011) |
Start Year | 2007 |
Description | Kings College London, UK |
Organisation | King's College London |
Department | School of Biomedical Sciences KCL |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We have an ongoing collaboration with the CARD at King's College London to evaluate the neurochemistry of post-stroke dementia. Prof Kalaria (lead PI) is also named as a PI on a Dunhill Trust funded project lead by Prof C Ballard att KCL. |
Collaborator Contribution | Exchange of reagents and post-mortem brain tissues |
Impact | There are several publications and one mansucript is in submission: PMID: 18303264, 19433439, 19776575 and 21988073. |
Start Year | 2007 |
Description | Kyoto University, Japan |
Organisation | University of Kyoto |
Department | Department of Neurology |
Country | Japan |
Sector | Academic/University |
PI Contribution | The vascular research group, Department of Neurology, Kyoto University (Prof Hidekazu Tomimoto and Dr Masafumi Ihara) has worked with us to explore the pathogenesis of brain white mater disease by establishing rodent models. |
Collaborator Contribution | We have shared research materials and reagents. |
Impact | Thus far we have published 5 peer-reviewed papers: PMID: 17761909, PMID: 19646974 and PMID: 21305033, PMID: 22133276, PMID: 22170742. |
Start Year | 2006 |
Description | Nanyang Technological University- Proteomic Analysis |
Organisation | Nanyang Technological University |
Country | Singapore |
Sector | Academic/University |
PI Contribution | We provided post-mortem brain tissues for analysis |
Collaborator Contribution | Collaborators performed proteomic analysis using state-of-the-art methods |
Impact | Publications |
Start Year | 2013 |
Description | National Cerebral and Cardiovascular Center Japan |
Organisation | National Cerebral and Cardiovascular Centre |
Department | Department of Stroke and Cerebrovascular Diseases |
Country | Japan |
Sector | Public |
PI Contribution | Developing an animal model of vascular dementia. My team provided the pathological reports on our dementia cases |
Collaborator Contribution | Developing and tesing the model after examing the pathological changes in brains from vascular dementia patients |
Impact | A publication describing a new animal model of vascular dementia [PubMed PMID: 22133276 Kitamura H et al, 2012] |
Start Year | 2012 |
Description | National Institute for Longevity Sciences (NILS), Japan |
Organisation | National Institute for Longevity Sciences (NILS) |
Country | Japan |
Sector | Public |
PI Contribution | The Vascular Dementia Research Department at NILS and the PIs have collaborated on cell molecular studies on the pathogenesis of brain arteriosclerosis using genetically manipulated cells and mouse models. |
Collaborator Contribution | Provided research reagents. |
Impact | There are two manuscripts in progress. Thus far, we have published the following papers: PMID: 16791082 and PMID: 19825845 |
Description | University College London, IoN, UK |
Organisation | University College London |
Department | Institute of Neurology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Institute of Neurology, UCL (Profs Nick Fox and Martin Rossor) collaboration over longitudinal MR data analysis and correlation of radiological findings against autopsy. |
Collaborator Contribution | Assistance in analysis of imaging data from the post-stroke survivor cohort |
Impact | We have used some of the methods developed by the UCL in our publications as PMID: 16934370 and 19022858. One other manuscript is in progress. |
Description | University Exeter |
Organisation | University of Exeter |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We provided cases for joint assessment of neuropathological criteria for vascular dementia |
Collaborator Contribution | In return we have had data on DNA methylation in vascular dementia cases |
Impact | One manuscript has been submitted for publication |
Start Year | 2017 |
Description | University of Bristol |
Organisation | University of Bristol |
Department | School of Clinical Sciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Network consortium to define diagnostic Criteria for vascular cognitive impairment |
Impact | Diagnostic guidelines VICCCS clinical and neuropathology (still in progress Delphi round V) |
Start Year | 2010 |
Description | University of Edinburgh, UK |
Organisation | University of Edinburgh |
Department | MRC Centre for Cognitive Ageing and Cognitive Epidemiology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The vascular research group at Edinurgh University (Dr Karen Horsburgh and Prof Ian Deary) has worked with us to explore the pathogenesis of brain white mater disease and cognition and behaviour in a rodent model. |
Collaborator Contribution | Sharing of new techniques and research materials |
Impact | Thus far one manuscript has been published (PMID: 20961660) and a joint study on Brain White matter Pathology is ongoing. |
Start Year | 2007 |
Description | University of Florence (LADIS), Italy |
Organisation | University of Florence |
Department | Department of Neurology |
Country | Italy |
Sector | Academic/University |
PI Contribution | We have an ongoing collaboration with the LADIS group (10 other EU sites) lead from the University of Florence group (Profs Domenico Inzitari and Leonardo Pantoni). The collaboration (lead by Prof J O'Brien) over LADIS (Leukoaraiosis and Disability in the Elderly Study), has currently produced over 36 peer-reviewed publications, 10 of these since 01/01/2006. |
Collaborator Contribution | Assistance in MR data analysis of white matter disease |
Impact | Several relevant publications have been produced by the joint collaboration. The following have not been provided in the publications list: PMID: 16490940, 16797787, 16866681, 16943684, 16955428, 17001023, 1721183, 17470472, 17766760, 18077477, 18216467, 18323505, 18347315, 18394928, 18556357, 18691285, 18703801, 19161174, 19204027, 19211595, 19218799, 19276621, 19581317, 19671212. |
Description | University of Glasgow, UK |
Organisation | University of Glasgow |
Department | School of Medicine Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Prof David Wyper at Glasgow University, has an active collaboration with us over development and testing of novel SPECT ligands for use in vascular dementia. |
Collaborator Contribution | Exchange of research materials and data anlysis |
Impact | We have used some of the methods developed by the University of Glasgow team in our publication PMID: 19269714 . One other manuscript is in progress. |
Start Year | 2006 |
Description | University of Goteborg, Sweden |
Organisation | University of Gothenburg |
Country | Sweden |
Sector | Academic/University |
PI Contribution | This collaboration with the Psychiatry Department (Dr Anne Borjesson) at the Univeristy of Gothenburg involves the genetic dissections of families with strokes and dementia. The study os dircelty relevant to the analysis of the post-stroke cohort in Newcastle |
Collaborator Contribution | Exchange of research materials |
Impact | One publication thus far (PMID: 17235124). One other manuscript on the neuropathological findings in familial multi-infarct dementia of the Swedish type is in progress. |
Start Year | 2006 |
Description | University of Helsinki, Finland |
Organisation | University of Helsinki |
Country | Finland |
Sector | Academic/University |
PI Contribution | The Vantaa 85+ study team from the Department of Neurology, Helsink and out team has worked together to analyse clinical data and postmortem brain tissue in parallel to the Newcastle post-stroke survivor study. |
Collaborator Contribution | Exchange of research materials and data |
Impact | Thus far one publication has been produced: PMID: 17923614 and PMID: 21048201. Another manuscript is in submission in Neurology entitled "No Association of Cerebral Amyloid Angiopathy with Frontal lobe white matter hyperintensities in the oldest old" by Tanskanen M et al. |
Start Year | 2006 |
Description | University of Lille |
Organisation | University of Lille |
Country | France |
Sector | Academic/University |
PI Contribution | We provided cases for joint assessment of radiological and neuropathological criteria for vascular dementia |
Collaborator Contribution | Partners in Lille (Department of Neurology) provided cases for joint assessment of radiological and neuropathological criteria for vascular dementia |
Impact | We have thus far published 3 peer-reviewed papers |
Start Year | 2011 |
Description | University of Sheffield, UK |
Organisation | University of Sheffield |
Department | School of Clinical Dentistry Sheffield |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We have an ongoing collaboration with the Neuropathology group at University of Sheffield to evaluate white matter pathology in MRC CFAS and current MRC funded project on post-stroke survivors. Prof Kalaria (lead PI) is also a PI on a MRC funded project lead by Prof P Ince in Sheffield. |
Collaborator Contribution | Shared research materials and reagents |
Impact | There are several publications and a couple in progress: PMID: 16627790, 17442062, 17990995 and 19109541. |
Description | University of Southampton |
Organisation | University of Southampton |
Department | Faculty of Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Providing research reagents and biological tissues from cases diagnosed in Newcastle |
Collaborator Contribution | Providing research reagents |
Impact | Joint publication [20122289 Zotova Elina et al (2010) Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy., Alzheimer's research & therapy 2, 1,] and presentations at two scientific meetings (January 2011) |
Start Year | 2009 |
Description | University of Sydney |
Organisation | University of Sydney |
Department | Psychiatry Sydney |
Country | Australia |
Sector | Academic/University |
PI Contribution | Network consortium. DSM V criteria- vascular cognitive component |
Collaborator Contribution | Members of a panel to discuss criteria for vascular cognitive disorders |
Impact | Diagnostic guidelines for Vascular Cognitve Disorder (VCD). Manuscript being revised for publication in The ADAD Journal (Sachdev P, Kalaria R, et al). |
Start Year | 2010 |
Description | 1ST INTERNATIONAL INTERDISCIPLINARY CONGRESS ON BEHAVIORAL HEALTH Qatar University |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | My plenary lecture stimulated interest on how we assess cognitive function in elderly stroke survivors |
Year(s) Of Engagement Activity | 2018 |
Description | ARUK Public meeting |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | Yes |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | There was much interest form the attendees. Questions posed to the panel as well as they too away literature on dementia. The feedback was excellent and there were requests for repeat with different topics in the dementia field. |
Year(s) Of Engagement Activity | 2012,2013,2014,2015 |
URL | http://www.ncl.ac.uk/ion/staff/profile/rajkalaria.html#research |
Description | Action on Dementia - Sunderland |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | About 40 persons including carers of dementia patients attended the lecture with considerable discussion afternwards on prevention and current treatments. Few of the audience attended Summer Dementia conference in Newcastle late rin June (at the Great NE Museum) sponsored by Alzheimer's Research UK. |
Year(s) Of Engagement Activity | 2011 |
Description | Alzheimer Research Trust- Fundraiser meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Gave a lecture to largely lay public and patients on our work and outcomes in dementia and consequences of stroke injury Some of the funds raised went to support local ART network team via the Trust. |
Year(s) Of Engagement Activity | 2007 |
Description | Alzheimer's Assciation International Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | About 500 attended the symposium on vascular cognitive disorders. Developing collaborations with two different laboratories |
Year(s) Of Engagement Activity | 2012 |
Description | Alzheimer's Society Local Chapters- Wallsend and Gateshead |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Gave lectures to largely lay public and patients on our work and outcomes in dementia and consequences of stroke injury More donations of brains for post-mortem analysis |
Year(s) Of Engagement Activity | 2006,2007 |
Description | Alzheimers Research UK |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Type Of Presentation | Workshop Facilitator |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Over 120 attended the Public meeting. There was much discussion during the lay scientific programme and individual visits to the four exhibit stands two of which were about the Brain Bank and Cognitive testing in patients. Few subsequent visits to our Institute where we conduct dementia research. |
Year(s) Of Engagement Activity | 2011 |
Description | BBC Radio Interview |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | This was through two different interviews (BBC local NE UK and World Service) on radio at NE BBC studios. Written to for more information |
Year(s) Of Engagement Activity | 2010 |
Description | BBC1 TV interview |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Gave interview on local news BBC1 about work on dementia and support of Northumberland artist to donate collection to Alzheimer's Research Trust Inquiry about artist and more support (donations) for local chapter of ART in June 2010 |
Year(s) Of Engagement Activity | 2009 |
Description | Familial stroke disorders- Hunters's Moor |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Seminar given to non-expert health professionals and patients Awareness of the long term consequences after stroke injury |
Year(s) Of Engagement Activity | 2007 |
Description | NANTZ Symposium on Alzheimer's Disease Houston Tx USA |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | My talks on cerebral small vessel diseases and post-stroke dementia were of much interest to the representatives from Industry in the audience. |
Year(s) Of Engagement Activity | 2019 |
Description | National Cerebral and Vascular Centre Osaka Japan |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Seminar given to the National Stroke Centre was of much interest to the officers of the Institute for follow up of stroke patients who survive. |
Year(s) Of Engagement Activity | 2018 |
Description | Panel Discussion |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | Yes |
Type Of Presentation | Workshop Facilitator |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | About 100 persons attended with much Q&A discussion. The Challenge of Ageing, 11 September 2013, Northern Stage, Newcastle University, Newcastle upon Tyne Request for more literature on Brain Ageing and Dementia |
Year(s) Of Engagement Activity | 2013 |
Description | Public Lecture at Prince Charles Hospital and Chinese University of Hong Kong |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | My seminar stimulated much interest in dementia diagnosis and treatment of small vessels diseases of the brain |
Year(s) Of Engagement Activity | 2018 |
Description | Public meeting |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | This even was the annual open public meeting to inform about Dementia studies in Newcastle, particularly update audience on developments stemming from the MRC award. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.ncl.ac.uk/ion/staff/profile/rajkalaria.html#research |
Description | Scientific Meeting on Vascular Factors in Dementia |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The Symposium was a great success and attended by approximately 120 people. The scientific programme was enthusiastically received and the intense sessions were delivered by some 40 different speakers and discussants. Sessions topics were timely and up to date with in depth discussions on dementia prevalence in UK and worldwide, risk factors, blood pressure, cardiovascular disease, stroke genetics, inflammation, repurposing of medications and the value of utilising large cohort studies. Numerous attendees commented this was one of the best conferences they had attended in recent months! |
Year(s) Of Engagement Activity | 2017 |
Description | Scientific Workshop on Small Vessels, Dementia and Chronic Diseases |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The MRC DPUK Vascular Disease Mechanisms Experimental Medicine (VEM) group identified a comprehensive assessment of the latest developments in animal models and of their contribution to understanding of cerebral microvascular disease to reduce the translational gap. The workshop brough together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. Presentations were from UK and international researchers with a specific focus on animal models of cerebral microvascular disease and dementia, considering vascular biology, neurovascular coupling, blood-brain barrier function, neuroinflammation, cerebral drainage pathways, and methodological and translational challenges. |
Year(s) Of Engagement Activity | 2017 |
Description | Small Vessel Diseases in Brain- Media |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Information on survival after stroke injury and incident dementia Write up in local Newspaper |
Year(s) Of Engagement Activity | 2008 |
Description | U3A on Vascular Factors- London |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Seminar given to students of U3A and interested public about our work in Newcastle on post-stroke dementia and brain donation Awareness and mention in U3A newsletter |
Year(s) Of Engagement Activity | 2007 |