Neuropathological Substrates of Dementia after Stroke

Lead Research Organisation: Newcastle University
Department Name: Institute for Ageing and Health

Abstract

Dementia is a major health problem which is increasing with the rising numbers of older people. Research effort in this field has focused largely on mechanisms that damage nerve-cells in disorders such as Alzheimer?s disease. Recent evidence suggests that impairments in blood supply to the brain may cause or accelerate these so-called ?neurodegenerative changes?. We have shown that 10% of patients who survive a stroke without severe memory problems, develop dementia in the following year. We have also highlighted possible risk associated with rapid changes in blood supply to the brain caused by disorders of cardiovascular regulation. The relationships between impaired blood supply, neurodegeneration and dementia are poorly understood. We propose to elucidate these, and identify the underlying mechanisms in older people who (a) have had a stroke and experience reduced blood supply to key subcortical regions of the brain. We will perform repeated clinical, psychological, cardiovascular and brain imaging assessments in these patients, to enable us to relate changes in memory and attention to structural damage to the brain. Most patients in our studies consent to brain donation at death, and we will compare pathological features with changes seen on brain imaging, and identify the molecular substrates of this damage. Our studies will advance understanding of the importance of how impariment occurs in stroke patients and in blood supply to the brain in dementia, and how this is affected by age. They will enable us to make more accurate, early diagnoses and identify those at risk of cognitive decline, and inform the development of therapies to slow or prevent such changes.
Our findings will be disseminated in many different ways, including: (i) publication in scientific journals; (ii) development of professional guidelines for the diagnosis and treatment of dementia and related medical conditions; (iii) inclusion in lay information bulletins and ?fact sheets? produced by bodies such as the Alzheimer?s Society, and US Alzheimer Association ;(iv) presentation at public lectures, workshops and carers support groups run by such organisations; and (v) through collaboration with Newcastle University?s Institute for Policy and Ethics in the Life Sciences (PEALS) whose main mission is to promote public engagement. Older people and representative voluntary organisations are involved in the strategic direction of research within the IAH and the management of facilities such as the brain tissue bank.

Technical Summary

Recent advances highlight the importance of vascular factors in the aetiopathogenesis of dementia but the relationships between vascular damage, cerebral hypoperfusion, neurodegenerative changes and cognitive decline remain unclear. We have previously shown (i) considerable overlap between Alzheimer?s disease and cerebrovascular disease, which is most pronounced in those aged over 80; (ii) 10% of older patients who survive a stroke without severe cognitive impairment at 3 months develop incident dementia in the first year; (iii) 30% of older stroke survivors show improvement in cognition over the first year; and (iv) a high proportion of patients with dementia have carotid sinus hypersensitivity (CSH) which correlates with the severity of small vessel disease.
Understanding the mechanisms for delayed dementia following stroke and the contribution of cerebral hypoperfusion to dementia, and the clinical characteristics which predict cognitive decline (or improvement) are essential if effective preventative strategies are to be developed. We will build upon our recent findings in post stroke dementia to address two key problems in a unique post-stroke cohort recruited and prospectively assessed during the last 5 years. Using pathological investigation of post-mortem specimens combined with in vivo imaging in post-stroke survivors, we will elucidate (i) whether cerebrovascular injury leads to increased burden of AD type changes in stroke survivors who become demented and (ii) whether increased burden of microvascular pathology in the subcortical structures (basal ganglia and thalamus) is a substrate for dementia in post-stroke survivors. Thus autopsy cases of post-stroke survivors will be examined for neuronal and microvascular pathology including Alzheimer lesions, cerebral amyloid angiopathy and hippocampal sclerosis and atrophy and subcortical WM pathology. To differentiate between post-stroke patients who decline and remain intact (improvers) we will also assess the expression of oxidative stress mechanisms in temporal lobe. Repeated assessments of clinical and neuropsychological measures prior to death will inform on the physical and cognitive status and be used to correlate with pathological findings and apolipoprotein E genotype. We believe the proposed research project will not only disclose the neuropathological substrates of post-stroke dementia but impact significantly on common dementing disorders in later life and underpin development of novel preventative and treatment strategies based on vascular protection.

Publications

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Allan LM (2007) Autonomic dysfunction in dementia. in Journal of neurology, neurosurgery, and psychiatry

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Allan LM (2013) Long-term incidence of depression and predictors of depressive symptoms in older stroke survivors. in The British journal of psychiatry : the journal of mental science

 
Description DSM V criteria on vascular cognitive impairment
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact This input to DSM committee will set new revised guidelines for diagnosis of dementia or cognitive function due to vascular disease. A manuscript resulting from these efforts has now been submitted for publication in Lancet Neurology (Sachdev P, Kalaria R et al, October 2011).
 
Description UK Dementia and Stroke Networks
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact UK plans to lead the criteria for Vascualar Dementia diagnosis
 
Description VCI Criteria Harmonisation- USA and Canada
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Consensus guidelines and criteria for the diagnosis (clinical, radiological, neuropsychological and pathological) of Vascular Cognitive Impairment
 
Description VICCS Classifcation for vascular contributions to dementia
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description ART Emergency Support
Amount £29,900 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2010 
End 12/2010
 
Description ART PhD Studentship
Amount £88,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2009 
End 08/2012
 
Description ART Pilot Project
Amount £150,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2010 
End 09/2011
 
Description ARUK Major Grant
Amount £435,000 (GBP)
Funding ID ARUK-PG2013-22 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2013 
End 12/2017
 
Description CADASIL Trust Research Fellowship
Amount £25,000 (GBP)
Organisation The CADASIL Research and Support Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2006 
End 12/2006
 
Description Centre in Long Life Well Being Scheme, funded by BBSRC, EPSRC, ESRC and MRC
Amount £4,252,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2008 
End 10/2013
 
Description DMT Research Project
Amount £250,000 (GBP)
Funding ID R2777/0213 
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2013 
End 12/2016
 
Description IBRO International Fellowship
Amount £37,000 (GBP)
Organisation International Brain Research Organisation (IBRO) 
Sector Academic/University
Country Global
Start 08/2009 
End 07/2011
 
Description MRC Brain Banks Programme- UKCRC Brain Bank Strategy
Amount £250,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2011 
End 08/2013
 
Description MRC Brain Banks Programme- UKCRC Brain Bank Strategy
Amount £374,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2011 
End 08/2013
 
Description NIH R21 Research Project
Amount £150,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 07/2006 
End 06/2008
 
Description Overseas Research Awards
Amount £35,000 (GBP)
Organisation Newcastle University 
Sector Academic/University
Country United Kingdom
Start 09/2009 
End 08/2010
 
Description Project Grant
Amount £561,607 (GBP)
Funding ID ARUK-PG2016B-6 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2016 
 
Description Project Grant
Amount £250,000 (GBP)
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2007 
End 08/2009
 
Description Project Grant
Amount £154,561 (GBP)
Funding ID AS-PG-17-007 
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 12/2020
 
Title 3D Stereology technique to assess Neurons 
Description Using post-mortem brain tissues from the post-stroke survivors cohort we have modified currently published methods to assess neuronal denisty and volumes by 3D stereology with light microscopy 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Plan to publish the techinque as a new method. 
 
Title Neuropsychological Profile for assessment of Post-Stroke Impairment 
Description A database has been created to assess the neuropsychological profile and risk factors for post-stroke dementia 
Type Of Material Database/Collection of Data/Biological Samples 
Provided To Others? No  
Impact Some of instruments arebeing used by a parallel study to assess post-stroke dementia in other population samples 
 
Description Buck Institute for Age Research 
Organisation Stroke group Buck Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution Sharing of reagents and brain tissue
Impact Manuscript for publication near completion (October 2011)
Start Year 2007
 
Description Kings College London, UK 
Organisation King's College London
Department School of Biomedical Sciences KCL
Country United Kingdom 
Sector Academic/University 
PI Contribution We have an ongoing collaboration with the CARD at King's College London to evaluate the neurochemistry of post-stroke dementia. Prof Kalaria (lead PI) is also named as a PI on a Dunhill Trust funded project lead by Prof C Ballard att KCL.
Collaborator Contribution Exchange of reagents and post-mortem brain tissues
Impact There are several publications and one mansucript is in submission: PMID: 18303264, 19433439, 19776575 and 21988073.
Start Year 2007
 
Description Kyoto University, Japan 
Organisation University of Kyoto
Department Department of Neurology
Country Japan 
Sector Academic/University 
PI Contribution The vascular research group, Department of Neurology, Kyoto University (Prof Hidekazu Tomimoto and Dr Masafumi Ihara) has worked with us to explore the pathogenesis of brain white mater disease by establishing rodent models.
Collaborator Contribution We have shared research materials and reagents.
Impact Thus far we have published 5 peer-reviewed papers: PMID: 17761909, PMID: 19646974 and PMID: 21305033, PMID: 22133276, PMID: 22170742.
Start Year 2006
 
Description Nanyang Technological University- Proteomic Analysis 
Organisation Nanyang Technological University
Country Singapore 
Sector Academic/University 
PI Contribution We provided post-mortem brain tissues for analysis
Collaborator Contribution Collaborators performed proteomic analysis using state-of-the-art methods
Impact Publications
Start Year 2013
 
Description National Cerebral and Cardiovascular Center Japan 
Organisation National Cerebral and Cardiovascular Centre
Department Department of Stroke and Cerebrovascular Diseases
Country Japan 
Sector Hospitals 
PI Contribution Developing an animal model of vascular dementia. My team provided the pathological reports on our dementia cases
Collaborator Contribution Developing and tesing the model after examing the pathological changes in brains from vascular dementia patients
Impact A publication describing a new animal model of vascular dementia [PubMed PMID: 22133276 Kitamura H et al, 2012]
Start Year 2012
 
Description National Institute for Longevity Sciences (NILS), Japan 
Organisation National Institute for Longevity Sciences (NILS)
Country Japan 
Sector Public 
PI Contribution The Vascular Dementia Research Department at NILS and the PIs have collaborated on cell molecular studies on the pathogenesis of brain arteriosclerosis using genetically manipulated cells and mouse models.
Collaborator Contribution Provided research reagents.
Impact There are two manuscripts in progress. Thus far, we have published the following papers: PMID: 16791082 and PMID: 19825845
 
Description University College London, IoN, UK 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Institute of Neurology, UCL (Profs Nick Fox and Martin Rossor) collaboration over longitudinal MR data analysis and correlation of radiological findings against autopsy.
Collaborator Contribution Assistance in analysis of imaging data from the post-stroke survivor cohort
Impact We have used some of the methods developed by the UCL in our publications as PMID: 16934370 and 19022858. One other manuscript is in progress.
 
Description University Exeter 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution We provided cases for joint assessment of neuropathological criteria for vascular dementia
Collaborator Contribution In return we have had data on DNA methylation in vascular dementia cases
Impact One manuscript has been submitted for publication
Start Year 2017
 
Description University of Bristol 
Organisation University of Bristol
Department School of Clinical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Network consortium to define diagnostic Criteria for vascular cognitive impairment
Impact Diagnostic guidelines VICCCS clinical and neuropathology (still in progress Delphi round V)
Start Year 2010
 
Description University of Edinburgh, UK 
Organisation University of Edinburgh
Department MRC Centre for Cognitive Ageing and Cognitive Epidemiology
Country United Kingdom 
Sector Public 
PI Contribution The vascular research group at Edinurgh University (Dr Karen Horsburgh and Prof Ian Deary) has worked with us to explore the pathogenesis of brain white mater disease and cognition and behaviour in a rodent model.
Collaborator Contribution Sharing of new techniques and research materials
Impact Thus far one manuscript has been published (PMID: 20961660) and a joint study on Brain White matter Pathology is ongoing.
Start Year 2007
 
Description University of Florence (LADIS), Italy 
Organisation University of Florence
Department Department of Neurology
Country Italy 
Sector Academic/University 
PI Contribution We have an ongoing collaboration with the LADIS group (10 other EU sites) lead from the University of Florence group (Profs Domenico Inzitari and Leonardo Pantoni). The collaboration (lead by Prof J O'Brien) over LADIS (Leukoaraiosis and Disability in the Elderly Study), has currently produced over 36 peer-reviewed publications, 10 of these since 01/01/2006.
Collaborator Contribution Assistance in MR data analysis of white matter disease
Impact Several relevant publications have been produced by the joint collaboration. The following have not been provided in the publications list: PMID: 16490940, 16797787, 16866681, 16943684, 16955428, 17001023, 1721183, 17470472, 17766760, 18077477, 18216467, 18323505, 18347315, 18394928, 18556357, 18691285, 18703801, 19161174, 19204027, 19211595, 19218799, 19276621, 19581317, 19671212.
 
Description University of Glasgow, UK 
Organisation University of Glasgow
Department School of Medicine Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Prof David Wyper at Glasgow University, has an active collaboration with us over development and testing of novel SPECT ligands for use in vascular dementia.
Collaborator Contribution Exchange of research materials and data anlysis
Impact We have used some of the methods developed by the University of Glasgow team in our publication PMID: 19269714 . One other manuscript is in progress.
Start Year 2006
 
Description University of Goteborg, Sweden 
Organisation University of Gothenburg
Country Sweden 
Sector Academic/University 
PI Contribution This collaboration with the Psychiatry Department (Dr Anne Borjesson) at the Univeristy of Gothenburg involves the genetic dissections of families with strokes and dementia. The study os dircelty relevant to the analysis of the post-stroke cohort in Newcastle
Collaborator Contribution Exchange of research materials
Impact One publication thus far (PMID: 17235124). One other manuscript on the neuropathological findings in familial multi-infarct dementia of the Swedish type is in progress.
Start Year 2006
 
Description University of Helsinki, Finland 
Organisation University of Helsinki
Country Finland 
Sector Academic/University 
PI Contribution The Vantaa 85+ study team from the Department of Neurology, Helsink and out team has worked together to analyse clinical data and postmortem brain tissue in parallel to the Newcastle post-stroke survivor study.
Collaborator Contribution Exchange of research materials and data
Impact Thus far one publication has been produced: PMID: 17923614 and PMID: 21048201. Another manuscript is in submission in Neurology entitled "No Association of Cerebral Amyloid Angiopathy with Frontal lobe white matter hyperintensities in the oldest old" by Tanskanen M et al.
Start Year 2006
 
Description University of Lille 
Organisation University of Lille
Country France 
Sector Academic/University 
PI Contribution We provided cases for joint assessment of radiological and neuropathological criteria for vascular dementia
Collaborator Contribution Partners in Lille (Department of Neurology) provided cases for joint assessment of radiological and neuropathological criteria for vascular dementia
Impact We have thus far published 3 peer-reviewed papers
Start Year 2011
 
Description University of Sheffield, UK 
Organisation University of Sheffield
Department School of Clinical Dentistry Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution We have an ongoing collaboration with the Neuropathology group at University of Sheffield to evaluate white matter pathology in MRC CFAS and current MRC funded project on post-stroke survivors. Prof Kalaria (lead PI) is also a PI on a MRC funded project lead by Prof P Ince in Sheffield.
Collaborator Contribution Shared research materials and reagents
Impact There are several publications and a couple in progress: PMID: 16627790, 17442062, 17990995 and 19109541.
 
Description University of Southampton 
Organisation University of Southampton
Department Faculty of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research reagents and biological tissues from cases diagnosed in Newcastle
Collaborator Contribution Providing research reagents
Impact Joint publication [20122289 Zotova Elina et al (2010) Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy., Alzheimer's research & therapy 2, 1,] and presentations at two scientific meetings (January 2011)
Start Year 2009
 
Description University of Sydney 
Organisation University of Sydney
Department Psychiatry Sydney
Country Australia 
Sector Academic/University 
PI Contribution Network consortium. DSM V criteria- vascular cognitive component
Collaborator Contribution Members of a panel to discuss criteria for vascular cognitive disorders
Impact Diagnostic guidelines for Vascular Cognitve Disorder (VCD). Manuscript being revised for publication in The ADAD Journal (Sachdev P, Kalaria R, et al).
Start Year 2010
 
Description 1ST INTERNATIONAL INTERDISCIPLINARY CONGRESS ON BEHAVIORAL HEALTH Qatar University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact My plenary lecture stimulated interest on how we assess cognitive function in elderly stroke survivors
Year(s) Of Engagement Activity 2018
 
Description ARUK Public meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact There was much interest form the attendees. Questions posed to the panel as well as they too away literature on dementia.

The feedback was excellent and there were requests for repeat with different topics in the dementia field.
Year(s) Of Engagement Activity 2012,2013,2014,2015
URL http://www.ncl.ac.uk/ion/staff/profile/rajkalaria.html#research
 
Description Action on Dementia - Sunderland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact About 40 persons including carers of dementia patients attended the lecture with considerable discussion afternwards on prevention and current treatments.

Few of the audience attended Summer Dementia conference in Newcastle late rin June (at the Great NE Museum) sponsored by Alzheimer's Research UK.
Year(s) Of Engagement Activity 2011
 
Description Alzheimer Research Trust- Fundraiser meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Gave a lecture to largely lay public and patients on our work and outcomes in dementia and consequences of stroke injury

Some of the funds raised went to support local ART network team via the Trust.
Year(s) Of Engagement Activity 2007
 
Description Alzheimer's Assciation International Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact About 500 attended the symposium on vascular cognitive disorders.

Developing collaborations with two different laboratories
Year(s) Of Engagement Activity 2012
 
Description Alzheimer's Society Local Chapters- Wallsend and Gateshead 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Gave lectures to largely lay public and patients on our work and outcomes in dementia and consequences of stroke injury

More donations of brains for post-mortem analysis
Year(s) Of Engagement Activity 2006,2007
 
Description Alzheimers Research UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Over 120 attended the Public meeting. There was much discussion during the lay scientific programme and individual visits to the four exhibit stands two of which were about the Brain Bank and Cognitive testing in patients.

Few subsequent visits to our Institute where we conduct dementia research.
Year(s) Of Engagement Activity 2011
 
Description BBC Radio Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact This was through two different interviews (BBC local NE UK and World Service) on radio at NE BBC studios.

Written to for more information
Year(s) Of Engagement Activity 2010
 
Description BBC1 TV interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Gave interview on local news BBC1 about work on dementia and support of Northumberland artist to donate collection to Alzheimer's Research Trust

Inquiry about artist and more support (donations) for local chapter of ART in June 2010
Year(s) Of Engagement Activity 2009
 
Description Familial stroke disorders- Hunters's Moor 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Seminar given to non-expert health professionals and patients

Awareness of the long term consequences after stroke injury
Year(s) Of Engagement Activity 2007
 
Description NANTZ Symposium on Alzheimer's Disease Houston Tx USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact My talks on cerebral small vessel diseases and post-stroke dementia were of much interest to the representatives from Industry in the audience.
Year(s) Of Engagement Activity 2019
 
Description National Cerebral and Vascular Centre Osaka Japan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Seminar given to the National Stroke Centre was of much interest to the officers of the Institute for follow up of stroke patients who survive.
Year(s) Of Engagement Activity 2018
 
Description Panel Discussion 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact About 100 persons attended with much Q&A discussion. The Challenge of Ageing, 11 September 2013, Northern Stage, Newcastle University, Newcastle upon Tyne

Request for more literature on Brain Ageing and Dementia
Year(s) Of Engagement Activity 2013
 
Description Public Lecture at Prince Charles Hospital and Chinese University of Hong Kong 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact My seminar stimulated much interest in dementia diagnosis and treatment of small vessels diseases of the brain
Year(s) Of Engagement Activity 2018
 
Description Public meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact This even was the annual open public meeting to inform about Dementia studies in Newcastle, particularly update audience on developments stemming from the MRC award.
Year(s) Of Engagement Activity 2016
URL http://www.ncl.ac.uk/ion/staff/profile/rajkalaria.html#research
 
Description Scientific Meeting on Vascular Factors in Dementia 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Symposium was a great success and attended by approximately 120 people. The scientific programme was enthusiastically received and the intense sessions were delivered by some 40 different speakers and discussants. Sessions topics were timely and up to date with in depth discussions on dementia prevalence in UK and worldwide, risk factors, blood pressure, cardiovascular disease, stroke genetics, inflammation, repurposing of medications and the value of utilising large cohort studies. Numerous attendees commented this was one of the best conferences they had attended in recent months!
Year(s) Of Engagement Activity 2017
 
Description Scientific Workshop on Small Vessels, Dementia and Chronic Diseases 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The MRC DPUK Vascular Disease Mechanisms Experimental Medicine (VEM) group identified a comprehensive assessment of the latest developments in animal models and of their contribution to understanding of cerebral microvascular disease to reduce the translational gap. The workshop brough together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. Presentations were from UK and international researchers with a specific focus on animal models of cerebral microvascular disease and dementia, considering vascular biology, neurovascular coupling, blood-brain barrier function, neuroinflammation, cerebral drainage pathways, and methodological and translational challenges.
Year(s) Of Engagement Activity 2017
 
Description Small Vessel Diseases in Brain- Media 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Information on survival after stroke injury and incident dementia

Write up in local Newspaper
Year(s) Of Engagement Activity 2008
 
Description U3A on Vascular Factors- London 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Seminar given to students of U3A and interested public about our work in Newcastle on post-stroke dementia and brain donation

Awareness and mention in U3A newsletter
Year(s) Of Engagement Activity 2007