Towards a new high-contrast modality of radiotherapy: resonant combination radiotherapy.

Lead Research Organisation: Queen's University of Belfast
Department Name: Research and Regional Services

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Coulter JA (2012) Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles. in International journal of nanomedicine

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Coulter JA (2013) Radiosensitising nanoparticles as novel cancer therapeutics--pipe dream or realistic prospect? in Clinical oncology (Royal College of Radiologists (Great Britain))

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Jain S (2014) Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions. in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

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Jain S (2011) Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies. in International journal of radiation oncology, biology, physics

 
Description CRUK funding (Characterisation of the Damage Responses Generated By The Presence of Gold Nanoparticles in Irradiated Cells. (CI status))
Amount £137,000 (GBP)
Funding ID C1278/A9901 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2008 
End 04/2011
 
Description EPSRC Public Outreach EP/F06652X/1 Radiation and Us, Visualising the Invisible
Amount £97,156 (GBP)
Funding ID EP/F06652X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2008 
End 02/2010
 
Title Technique to speed up Monte Carlo calculations 
Description As a spin-off from our modeling calculations we have developed a means to speed them up by a factor of between 100 and 1000. A patent has recently been filed regarding this method. 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact None yet although we anticipate this becoming a widely used technique in therapy planning 
 
Description Gold Nanoparticle Dose Enhancement 
Organisation Queen's University Belfast
Department School of Pharmacy
Country United Kingdom 
Sector Academic/University 
PI Contribution Developed means to irradiate biological samples at the Diamond synchrotron with very high efficiency Performed irraditions
Collaborator Contribution Sharing expertise and resourcesProvided biological handling facilities essential for our research
Impact 4 papers are currently under preparation
Start Year 2007
 
Description Gold Nanoparticle Dose Enhancement 
Organisation Rutherford Appleton Laboratory
Country United Kingdom 
Sector Public 
PI Contribution Developed means to irradiate biological samples at the Diamond synchrotron with very high efficiency Performed irraditions
Collaborator Contribution Sharing expertise and resourcesProvided biological handling facilities essential for our research
Impact 4 papers are currently under preparation
Start Year 2007
 
Description Gold nanoparticle dose enhancement 
Organisation Queen's University Belfast
Department Centre for Cancer Research and Cell Biology
Country United Kingdom 
Sector Academic/University 
PI Contribution Detailed Monte Carlo modeling of pertinent radiation transport, studies of DNA damage in plasmid + cell systems, development of bespoke system for dose painting at Diamond synchrotron
Collaborator Contribution Access to facilities to perform assaysJointly held PhD studentships, access to radiation sourcesprovision of bespoke gold nanoparticle preparations Expertise sharing, particularly in Monte Carlo calculations
Impact First radiobiology studies at the Diamond synchrotron (pubs in prep).
Start Year 2006
 
Description Gold nanoparticle dose enhancement 
Organisation Queen's University Belfast
Department School of Pharmacy
Country United Kingdom 
Sector Academic/University 
PI Contribution Detailed Monte Carlo modeling of pertinent radiation transport, studies of DNA damage in plasmid + cell systems, development of bespoke system for dose painting at Diamond synchrotron
Collaborator Contribution Access to facilities to perform assaysJointly held PhD studentships, access to radiation sourcesprovision of bespoke gold nanoparticle preparations Expertise sharing, particularly in Monte Carlo calculations
Impact First radiobiology studies at the Diamond synchrotron (pubs in prep).
Start Year 2006
 
Description Gold nanoparticle dose enhancement 
Organisation University of Bath
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Detailed Monte Carlo modeling of pertinent radiation transport, studies of DNA damage in plasmid + cell systems, development of bespoke system for dose painting at Diamond synchrotron
Collaborator Contribution Access to facilities to perform assaysJointly held PhD studentships, access to radiation sourcesprovision of bespoke gold nanoparticle preparations Expertise sharing, particularly in Monte Carlo calculations
Impact First radiobiology studies at the Diamond synchrotron (pubs in prep).
Start Year 2006
 
Description Gold nanoparticle dose enhancement 
Organisation Vanderbilt University
Country United States 
Sector Academic/University 
PI Contribution Detailed Monte Carlo modeling of pertinent radiation transport, studies of DNA damage in plasmid + cell systems, development of bespoke system for dose painting at Diamond synchrotron
Collaborator Contribution Access to facilities to perform assaysJointly held PhD studentships, access to radiation sourcesprovision of bespoke gold nanoparticle preparations Expertise sharing, particularly in Monte Carlo calculations
Impact First radiobiology studies at the Diamond synchrotron (pubs in prep).
Start Year 2006
 
Description Use of Diamond Light Source/ Research Complex at Harwell 
Organisation Diamond Light Source
Country United Kingdom 
Sector Academic/University 
PI Contribution Developed system to irradiate biological samples at Diamond. Planned and performed experiments
Collaborator Contribution About £300k worth of facility beam time access3 weeks access to tissue culture labs and state of the art microscopy
Impact 2 papers to day, 3 more in prep
Start Year 2008
 
Description Use of Diamond Light Source/ Research Complex at Harwell 
Organisation Diamond Light Source
Country United Kingdom 
Sector Academic/University 
PI Contribution Developed system to irradiate biological samples at Diamond. Planned and performed experiments
Collaborator Contribution About £300k worth of facility beam time access3 weeks access to tissue culture labs and state of the art microscopy
Impact 2 papers to day, 3 more in prep
Start Year 2008
 
Title SYSTEM AND METHODS FOR ACCELERATING SIMULATIONS OF RADIATION TREATMENT 
Description In extending the Monte Carlo calculations we preformed under this grant and after that funding period, we developed a means to speed up Monte Carlo calculations by a factor of between 100 and 1000. Since Monte Carlo is the gold standard by which radiation transport calculations are made, this invention is likely to have a wide impact both in therapy planning and radiation research. 
IP Reference WO2010048074 
Protection Patent granted
Year Protection Granted 2010
Licensed No
Impact N/A
 
Description Radiation + Us project 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact EPSRC outreach project to develop exhibits relating to uses of medical physics in W5, Northern Ireland's premier science interaction centre

Project is ongoing but exciting interactive exhibits have been developed.
Year(s) Of Engagement Activity 2008,2009