The genetic and cellular basis of human to human transmission of influenza virus

Lead Research Organisation: Imperial College London
Department Name: Unlisted

Abstract

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Technical Summary

The trigger for moving from the current level of pandemic alert to the next is the recognition of sustained human to human transmission of a novel influenza virus through the community. Yet we understand little about how these viruses do transmit and why viruses that remain essentially avian-like do not. We hypothesize that a major factor is the cell tropism of influenza virus which differs in human airways between avian and human influenza strains. The ferret is the best animal model to study human influenza. In this project a series of recombinant viruses that differ only their airway tropism will be generated and their transmission properties quantified. The findings will be related to viruses that bear H5N1 surface antigens. The contribution of other viral genes to transmissibility of humanized avian influenza viruses in ferrets will also be assessed.

Publications

10 25 50

 
Description Clinical Research Fellowship
Amount £50,000 (GBP)
Organisation Imperial College London 
Department Imperial College Trust
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 09/2017
 
Description Collaborative Award
Amount £1,266,454 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 03/2020
 
Description Developing an in vitro approach to study transmission of respiratory viruses
Amount £399,896 (GBP)
Funding ID NC/K00042X/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2013 
End 04/2016
 
Description FLUPIG Pathogenesis and transmission of influenza virus in pigs (5m euros across 10 participants)
Amount £324,822 (GBP)
Funding ID 258084 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 05/2010 
End 12/2014
 
Description FLUPIG Pathogenesis and transmission of influenza virus in pigs (5m euros across 10 participants)
Amount £345,000 (GBP)
Funding ID 258084 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 05/2010 
End 12/2014
 
Description Virulence and transmissibility of swine influenza H1N1 virus and options for its control (Imperial College BRC)
Amount £348,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Imperial Biomedical Research Centre
Sector Public
Country United Kingdom
Start 09/2009 
End 09/2011
 
Description Wellcome Trust Programme Grant (Mechanisms and consequences of interferon induction by influenza viruses)
Amount £1,000,345 (GBP)
Funding ID 087039 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2009 
End 05/2015
 
Title Ferrets as research model for human influenza 
Description Development at Imperial College of the ferret model for influenza virus transmission has led to further work to develop the model to study symptoms. This includes constant temperature telemetry via surgical implantd and respirtaory function measurements via plethysmography. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2009 
Provided To Others? Yes  
Impact We are now in process of negotiating a collaboration with a small company housed in the IC bioincubator to test the efficacy of one of their drugs to alleviate influenza symptoms. 
 
Description ANTIFLU 
Organisation Max Planck Society
Country Germany 
Sector Charity/Non Profit 
PI Contribution Providing specialist influenza experience and research
Collaborator Contribution Access ot a large data set pf host genes that may be invovled in influenza replication. Access to new technologies
Impact None yet
Start Year 2011
 
Description FLUPIG 
Organisation Animal Health And Veterinary Laboratories Agency (AHVLA)
Country United Kingdom 
Sector Public 
PI Contribution Investigating teh role of polymerase in restriction of avian influenza in pigs
Collaborator Contribution Investigating the role of pigs in pandemci influenza
Impact Investigation of influenza polymerase activity in pig cells. Moncorgé O, Long JS, Cauldwell AV, Zhou H, Lycett SJ, Barclay WS. J Virol. 2012 Oct 17. [Epub ahead of print]
Start Year 2010
 
Description Media interviews 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The publication of our PLOs One article was accompanied by a press release to which we responded with telephone interviews.

This and other responses has led to Professor Barclay becoming well known to the media and being a frequent communicator on matters of influenza virus emegergence such as the threat posed by the swine flu pandemic of 2009.
Year(s) Of Engagement Activity 2009,2010,2011,2012,2013,2014
 
Description School visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact School talks given both by myself and Dr Roberst to school children ages ranging from 11-18 and their parenst at locations in Berkshire and London sparked many questions on influenza. Particularly pertinent last year 2009 during the early months of the swine influenza pandemic.

School thanked us. Memebr of teh audience has asled to carry out a labortaor project with our lab.
Year(s) Of Engagement Activity 2008,2009,2010