Flu watch:Community study of behavioral & biological determinants of transmission to inform seasonal & pandemic planning

Lead Research Organisation: University College London
Department Name: Unlisted

Abstract

The current concern about bird flu is because very occasionally new strains of influenza can emerge from animals and adapt to spread rapidly from person to person. In the past this has led to worldwide epidemics (pandemics) of severe influenza. The most dramatic event was in 1917/1918 when an influenza pandemic killed more people than the second world war. A strain of influenza which can spread from birds to humans and which leads to very severe illness has emerged and is beginning to spread globally. Fortunately it does not spread easily from person to person so the number of cases are small. If the virus mutates to spread easily amongst humans then there could be another pandemic. Every year strains of influenza that can spread very easily between humans (seasonal influenza) cause many people to become unwell and lead to many extra hospitalisations and deaths particularly in elderly people and those with chronic illnesses. We need to understand how flu spreads through society and how our immune system fights the infection. This large community-based study of influenza in households will increase our understanding of seasonal influenza. A better understanding of how seasonal influenza spreads and how our immune system responds will also help us understand how pandemic influenza might spread and may help us develop strategies to reduce the impact of a pandemic. If a pandemic does happen we will need to respond quickly with studies that will help us to understand how the virus is affecting humans and what treatments are most effective. This proposal will increase our understanding of seasonal influenza, help us prepare for a pandemic and ensure that we are ready to study a pandemic if it does occur.

Technical Summary

During an influenza pandemic studies of antiviral effectiveness, transmission dynamics, immunological and clinical response will need immediate implementation. It will be impossible to set up such studies without having a pre-enrolled cohort and established data collection methodologies.

Current empirical understanding of influenza transmission dynamics primarily rests on studies from the 1950s-1970s and limited data from previous pandemics. These studies were undertaken without the benefits of modern molecular technology at a time when social structures and mobility patterns were very different from today. Many of our mathematical models which inform planning are based on these historical data.

Studies of immunological correlates of protection have focused on neutralizing antibodies but there are no data on T-cell mediated protection in humans in natural respiratory infection. T-cells responses exhibit cross-reactivity between different virus subtypes so if pandemic influenza was imminent, it would be possible to enhance this type of immunity by vaccination.

In a collaboration between the UCL Centre for Infectious Disease Epidemiology, the MRC Human Immunology Unit, the MRC General Practice Research Framework (GPRF) and the Health Protection Agency we propose to establish a preparedness cohort of 2000 enrolled participants enabling timely study of a pandemic and to use this cohort in the pre-pandemic period to conduct a series of behavioral, virological, immunological and clinical studies of seasonal influenza. Through the GPRF we will recruit 1000 individuals in 2006/7 and a further 1000 in 2007/8 in households throughout the UK. We will follow each cohort through the following influenza season. In the event of a pandemic the entire cohort will be re-instated. Cases of influenza infection will be defined through pre-and post season serology and divided into symptomatic and asymptomatic cases based on symptom diaries. Viral shedding will be identified through self-submitted nasal swabs for RT-PCR identification of influenza. Information on patient contact patterns will be collected providing empirical data to inform models of pandemic and seasonal influenza transmission. In nested case control studies pre and post season blood samples from patients with confirmed influenza and controls will be used to assess the T cell response to influenza using a validated interferon-gamma elispot assay. We hypothesize that pre-existing T cell immunity will be greater in those with symptomatic influenza infection and in confirmed viral shedders than in those with asymptomatic infection.

We will use methodology and data from the study to enable the development of empirical trials of antiviral and behavioural interventions.

Publications

10 25 50
 
Description Development of HPA Community influenza surveillance
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description HPA estimates of burden of pandemic influenza
Geographic Reach UK 
Policy Influence Type Citation in other policy documents
Impact The Flu Watch work fed into the HPA modelling group that estimated the number of cases of pandemic influenza. This informed policy decisions on the response to the pandemic.
 
Description Invited to be member of Joint Committee on Vaccination and Immunisation Influenza Subcommittee
Geographic Reach UK 
Policy Influence Type Participation in advisory committee
Impact Evidence on incidence of influenza has been important in continuing considerations about whether to immunise children against influenza
 
Description JCVI decision to recommend routine influenza immunisation of children
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
 
Description JCVI influenza vaccination committee
Geographic Reach UK 
Policy Influence Type Membership of a guidance committee
Impact Results of Flu Watch Data influenced decisions on national panjdemic vaccination strategy by demonstrating low level of severity of pandemic strain.
 
Description JCVI review of effectiveness and cost effectiveness of the national influenza vaccination programme
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
 
Description JCVI review of whether to introduce routine childhood vaccination for influenza
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
 
Description NERV-TAG
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description SPI-M
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Clinical Research and Development Committee Research Funding from the BRC/UCLH Charities - Fast Track Grant - Charlotte Warren-Gash
Amount £37,890 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 12/2014 
End 03/2016
 
Description EPSRC IRC in Early-Warning Sensing Systems for Infectious Diseases
Amount £20,285 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 02/2016 
End 01/2017
 
Description Exploratory Project Funding call 'Early Warning Sensing Systems for Influenza'
Amount £113,040 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Department Flusurvey
Sector Public
Country United Kingdom
Start 08/2014 
End 07/2015
 
Description NIH/CDC call for funding on influenza transmission
Amount £6,900,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start  
 
Description NIHR 2011 call for Pandemic Research
Amount £431,356 (GBP)
Funding ID 11/46/09 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2013 
End 08/2016
 
Description NIHR methods fellowship
Amount £150,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2014 
End 03/2016
 
Description NIHR research training fellowship - Dr Logan Manikam
Amount £180,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description UCLH CBRC Clinical Research and Development Committee
Amount £30,000 (GBP)
Organisation National Institute for Health Research 
Department UCLH/UCL Biomedical Research Centre
Sector Public
Country United Kingdom
Start  
 
Description Wellcome Doctoral Training Award - Nischay Mehtha - variations in adult tonsillectomy rates
Amount £180,000 (GBP)
Organisation University of Oxford 
Department Wellcome Trust Doctoral Training Fellowship
Sector Academic/University
Country United Kingdom
Start  
 
Description Wellcome Mosaic extension
Amount £19,052 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Title HPA serosurveillance 
Description Contributing to plans for ongoing HPA serosurveillance of influenza 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2011 
Provided To Others? Yes  
Impact Informing design of future national surveillance 
 
Title Use of Health Survey for England as a tool for monitoring population infection 
Description HSE is a national rolling household study including taking of blood. We have added influenza serology to this and can compare results to Flu Watch. THe HSE provides a way forward for obtaining some of the key parameters measured in Flu Watch more efficiently 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact NIHR funded grant exploring use of HSE as a tool for pandemic preparedness 
 
Title Weekly automated telephone calls for collection of data on illnesses in households 
Description We have developed (via subcontractors) tools for the automated monitoring of illnesses in household on a weekly basis using automated telphone calls 
Type Of Material Improvements to research infrastructure 
Year Produced 2009 
Provided To Others? Yes  
Impact We have provided ths to the Swine Flu Initiative BBSRC grant to monitor rates of illness in Pig Workers 
 
Title weekly automated online surveys for collection of household level data 
Description We developed the use of weekly online surveys for monitoring the incidence of illness in households 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Enabled subsequent development of similar methodologies for monitoring pandemnic influenza We propose to use this methodology in a Phase IIb Trial testing the efficacy of an improved influenza vaccine in older adults. We have submitted an itial funding application for this through the MRC's EME programme. 
 
Description COSI 
Organisation University of Cambridge
Department Department of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Organsation of collection of sera from Pig Farmers and Pig Workers
Collaborator Contribution Understanding of burden of influenza in populations working with pigs.Testing of human sera for evidence of range of swine flu viruses.
Impact Level of serologically confirmed influenza in pig workers. Paper in preparation outlining increased risk of influenza in pig workers compared to community controls
Start Year 2009
 
Description COSI 
Organisation University of Cambridge
Department Department of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Collection of serological samples from pig workers - provision of non pig worker controls from Flu Watch
Collaborator Contribution Investigation of exposure to pigs as a risk factor for infection with influenza
Impact Immune responses in pigs vaccinated with adjuvanted and non-adjuvanted A(H1N1)pdm/09 influenza vaccines used in human immunization programmes. Lefevre EA, Carr BV, Inman CF, Prentice H, Brown IH, Brookes SM, Garcon F, Hill ML, Iqbal M, Elderfield RA, Barclay WS, Gubbins S, Bailey M, Charleston B; COSI. PLoS One. 2012;7(3):e32400. Epub 2012 Mar 9.
Start Year 2009
 
Description COSI 
Organisation Veterinary Laboratories Agency
Country United Kingdom 
Sector Public 
PI Contribution Organsation of collection of sera from Pig Farmers and Pig Workers
Collaborator Contribution Understanding of burden of influenza in populations working with pigs.Testing of human sera for evidence of range of swine flu viruses.
Impact Level of serologically confirmed influenza in pig workers. Paper in preparation outlining increased risk of influenza in pig workers compared to community controls
Start Year 2009
 
Description EMIT 
Organisation Nottingham University Hospitals NHS Trust
Department Division of Epidemiology and Public Health
Country United Kingdom 
Sector Academic/University 
PI Contribution EMIT: Evaluating Modes of Influenza Transmission using a Human Challenge $10,849,395 Model. Data annd expertisre from Flu Watch has been used to inform the design of this human challenge study to understand the role of earosols in transmission.
Collaborator Contribution Use of Human Challenge studies to study influenza transmission and immunity is complementary approach to observational studies of Influenza
Impact Multidisciplinary research project involving epidemiologisy, public health, aerobiology, virology, modelling.
Start Year 2011
 
Description EVIDENT 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution 1) co-supervision of a Wellcome Doctoral Training award student (Nishay Mehtha) - Variations in adult tonsillectomy rates. 2) co-supervision of an NIHR research training fellow (Dr Logan Manikam) - respiratory infections in children with Down's syndrome.
Collaborator Contribution 1) co-supervision of a Wellcome Doctoral Training award student (Nishay Mehtha) - Variations in adult tonsillectomy rates. 2) co-supervision of an NIHR research training fellow (Dr Logan Manikam) - respiratory infections in children with Down's syndrome.
Impact none yet
Start Year 2013
 
Description Health Survey for England 
Organisation Department of Health (DH)
Country United Kingdom 
Sector Public 
PI Contribution Design of Influenza questions to include in the Health Survey for England in the pandemic year
Collaborator Contribution Use of HSE as a tool to monitor population infection rates in vaccinated and unvaccinated
Impact Recently awarded NIHR grant to explore use of Health Survey for England as a tool to monitor population levels of infection during a pandemic.
Start Year 2009
 
Description Health Survey for England 
Organisation National Centre for Social Research
Country United Kingdom 
Sector Academic/University 
PI Contribution Design of Influenza questions to include in the Health Survey for England in the pandemic year
Collaborator Contribution Use of HSE as a tool to monitor population infection rates in vaccinated and unvaccinated
Impact Recently awarded NIHR grant to explore use of Health Survey for England as a tool to monitor population levels of infection during a pandemic.
Start Year 2009
 
Description ICONIC 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Andrew Hayward is leading the epidemiological aspects of the grant which focuses on sequencing of all influenza isolates across 4 london trust as well as selected PHE samples.
Collaborator Contribution working with Wellcome Sanger Institute (sequencing side) and PHE (specimens and data)
Impact grant started autumn 2013
Start Year 2013
 
Description ICONIC 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Andrew Hayward is leading the epidemiological aspects of the grant which focuses on sequencing of all influenza isolates across 4 london trust as well as selected PHE samples.
Collaborator Contribution working with Wellcome Sanger Institute (sequencing side) and PHE (specimens and data)
Impact grant started autumn 2013
Start Year 2013
 
Description Influenza Mortality 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Flu Watch data on influenza occurrence provided to contribute to modelling of seasonal and pandemic case fatality rates.
Collaborator Contribution Bayesian approach to modelling of mortality
Impact Analysis ongoing
Start Year 2012
 
Description Influenza Mortality 
Organisation University of Cambridge
Department MRC Biostatistics Unit
Country United Kingdom 
Sector Public 
PI Contribution Flu Watch data on influenza occurrence provided to contribute to modelling of seasonal and pandemic case fatality rates.
Collaborator Contribution Bayesian approach to modelling of mortality
Impact Analysis ongoing
Start Year 2012
 
Description Influenza and Myocardial Infarction 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Department Primary Care PHC
Country United Kingdom 
Sector Academic/University 
PI Contribution Research into the triggering effect of influenza on MI using surveillance trends and contextualised using Flu Watch Data.
Collaborator Contribution Supervision of MRC Clinical Research Fellow Charlotte Warren Gash
Impact Influenza infection and acute myocardial infarction risk. C. Warren-Gash, A.Hayward, S.Thomas, H.Whitaker, L.Smeeth. Journal of Infectious Diseases. Warren-Gash C, Smeeth L, Hayward A. Influenza and myocardial infarction. Expert Rev Cardiovasc Ther. 2010 Feb;8(2):143-6. Warren-Gash C, Smeeth L, Hayward AC. Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review. Lancet Infect Dis. 2009 Oct;9(10):601-10.
Start Year 2007
 
Description Influenza and Myocardial Infarction 
Organisation University of Hong Kong
Department School of Public Health and Department of Community Medicine
Country Hong Kong 
Sector Academic/University 
PI Contribution Research into the triggering effect of influenza on MI using surveillance trends and contextualised using Flu Watch Data.
Collaborator Contribution Supervision of MRC Clinical Research Fellow Charlotte Warren Gash
Impact Influenza infection and acute myocardial infarction risk. C. Warren-Gash, A.Hayward, S.Thomas, H.Whitaker, L.Smeeth. Journal of Infectious Diseases. Warren-Gash C, Smeeth L, Hayward A. Influenza and myocardial infarction. Expert Rev Cardiovasc Ther. 2010 Feb;8(2):143-6. Warren-Gash C, Smeeth L, Hayward AC. Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review. Lancet Infect Dis. 2009 Oct;9(10):601-10.
Start Year 2007
 
Description Influenza in Homeless 
Organisation University College London Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Provision of Flu Watch data on general population eligibility and uptake to influenza vaccine to compare with equivalent data in homeless people
Collaborator Contribution Collection of data on influenza vaccine eligibility and uptake in homeless people
Impact Paper submitted to BMJ
Start Year 2012
 
Description MOSAIC 
Organisation Imperial College Healthcare NHS Trust
Department Respiratory Medicine
Country United Kingdom 
Sector Hospitals 
PI Contribution Collection of genetic samples from community controls to compare to severe cases of influenza
Collaborator Contribution Genetic analyses of determinants of severe influenza
Impact IFITM3 restricts the morbidity and mortality associated with influenza. Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB; GenISIS Investigators; MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. Nature. 2012 Mar 25;484(7395):519-23. doi: 10.1038/nature10921. Multidisciplinary collaboration. Geneticists, clinicians, epidemiologists
Start Year 2010
 
Description MOSAIC 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Collection of genetic samples from community controls to compare to severe cases of influenza
Collaborator Contribution Genetic analyses of determinants of severe influenza
Impact IFITM3 restricts the morbidity and mortality associated with influenza. Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB; GenISIS Investigators; MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. Nature. 2012 Mar 25;484(7395):519-23. doi: 10.1038/nature10921. Multidisciplinary collaboration. Geneticists, clinicians, epidemiologists
Start Year 2010
 
Description NIHR Health Protection Research Unit in Respiratory Infection 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Andrew Hayward is the proposed director of this unit and led the bid. Bid focuses on public health research on influenza and TB and builds extensively on the Flu Watch methodology.
Collaborator Contribution UoN and RCGP are contributing primarily to the emergency response theme which focuses on pandemic response.
Impact short-listed and interviewed. awaiting result.
Start Year 2013
 
Description NIHR Health Protection Research Unit in Respiratory Infection 
Organisation Royal College of General Practitioners
Department RCGP Research and Surveillance Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution Andrew Hayward is the proposed director of this unit and led the bid. Bid focuses on public health research on influenza and TB and builds extensively on the Flu Watch methodology.
Collaborator Contribution UoN and RCGP are contributing primarily to the emergency response theme which focuses on pandemic response.
Impact short-listed and interviewed. awaiting result.
Start Year 2013
 
Description NIHR Health Protection Research Unit in Respiratory Infection 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Andrew Hayward is the proposed director of this unit and led the bid. Bid focuses on public health research on influenza and TB and builds extensively on the Flu Watch methodology.
Collaborator Contribution UoN and RCGP are contributing primarily to the emergency response theme which focuses on pandemic response.
Impact short-listed and interviewed. awaiting result.
Start Year 2013
 
Description Tcell Vaccine Trial full grant application to MRC-EME scheme 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributed to trial design, particularly in the area of measuring outcomes and sample size.
Collaborator Contribution Led the application
Impact Awaiting to hear funding decision
Start Year 2013
 
Description Tcell Vaccine Trial outline grant application to MRC-EME 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Flu Watch data used to develop power calculations for the trail. Flu Watch methodology will be used to collect outcome data being led by UCL.
Collaborator Contribution Oxford University has developed the Tcell vaccine and will lead the trial if funded.
Impact Tcell Vaccine Trial outline grant application submitted to MRC-EME
Start Year 2013
 
Description Trial of a T-cell vaccine 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution We are presently arranging a collaboration with the University of Oxford regarding a trial of a T-cell Vaccine.
Collaborator Contribution The contributions we will make are still be arranged
Impact .
Start Year 2016
 
Description UKCRC Translational Infection Research Initiative Strategy Development Grant - Influenza Transmission Strategy Development Group November 2007-November 2008 £80,000 
Organisation Imperial College London
Department Department of Epidemiology and Biostatistics
Country United Kingdom 
Sector Academic/University 
PI Contribution Working group to identify means of studying influenza transmission. Our data on household transmission rates were used to help design further work on human experimental models of influenza transmission.
Impact DH funded grant to assess the feasability of using human volunteers in studies of influenza transmission. The final report has been made to DH and this demonstrates that human volunteer studies have potential to be used for transmission studies. Further frunding for such studies is being sought.
Start Year 2008
 
Description UKCRC Translational Infection Research Initiative Strategy Development Grant - Influenza Transmission Strategy Development Group November 2007-November 2008 £80,000 
Organisation University of Nottingham
Department School of Community Health Sciences Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Working group to identify means of studying influenza transmission. Our data on household transmission rates were used to help design further work on human experimental models of influenza transmission.
Impact DH funded grant to assess the feasability of using human volunteers in studies of influenza transmission. The final report has been made to DH and this demonstrates that human volunteer studies have potential to be used for transmission studies. Further frunding for such studies is being sought.
Start Year 2008
 
Description i-sense exploratory grant 
Organisation Google
Country United States 
Sector Private 
PI Contribution Designing and running the patient and public engagement part of the project. Providing Flu Watch data for calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Collaborator Contribution LSHTM is running flusurvey surveillance project and piloting the diagnostic testing component. Public Health England is conducting PCR analysis of samples. Exploring with google possible collaboration on surveillance recruitment methods. Calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Impact 1) currently developing a smartphone app for participatory surveillance of influenza-like-illness 2) currently running flusurvey study for another year
Start Year 2014
 
Description i-sense exploratory grant 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Designing and running the patient and public engagement part of the project. Providing Flu Watch data for calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Collaborator Contribution LSHTM is running flusurvey surveillance project and piloting the diagnostic testing component. Public Health England is conducting PCR analysis of samples. Exploring with google possible collaboration on surveillance recruitment methods. Calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Impact 1) currently developing a smartphone app for participatory surveillance of influenza-like-illness 2) currently running flusurvey study for another year
Start Year 2014
 
Description i-sense exploratory grant 
Organisation Microsoft Research
Country Global 
Sector Private 
PI Contribution Designing and running the patient and public engagement part of the project. Providing Flu Watch data for calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Collaborator Contribution LSHTM is running flusurvey surveillance project and piloting the diagnostic testing component. Public Health England is conducting PCR analysis of samples. Exploring with google possible collaboration on surveillance recruitment methods. Calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Impact 1) currently developing a smartphone app for participatory surveillance of influenza-like-illness 2) currently running flusurvey study for another year
Start Year 2014
 
Description i-sense exploratory grant 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Designing and running the patient and public engagement part of the project. Providing Flu Watch data for calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Collaborator Contribution LSHTM is running flusurvey surveillance project and piloting the diagnostic testing component. Public Health England is conducting PCR analysis of samples. Exploring with google possible collaboration on surveillance recruitment methods. Calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Impact 1) currently developing a smartphone app for participatory surveillance of influenza-like-illness 2) currently running flusurvey study for another year
Start Year 2014
 
Description Decipher My Data 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact DECIPHER MY DATA!
A research project conducted by Farr London through
scientific engagement with schools, promoting the idea
that students benefit from performing real science using
real data in the classroom. Findings from Decipher my
data! Flu! based on data from 27 schools show that
school sickness absence data are correlated with influenza
surveillance data and may provide a good warning
system for spotting flu outbreaks .
Year(s) Of Engagement Activity 2015
 
Description I'm a scientist Decipher my Data 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact As part of a Wellcome trust funded public Engagement award we helped to design data collection from schools on school sickness absence. This was used to compare with trends in influenza surveillance with data provided in real time to schools. Flu Watch info included in educational materials,

http://flu.deciphermydata.org.uk/
40 schools partcipated in 2011/12

60 have expressed interest in participating for 2012/13
Year(s) Of Engagement Activity 2010,2011,2012
URL http://flu.deciphermydata.org.uk/
 
Description Pulse Magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Article in Pulse Magazine on levels of Flu inthe Community - target audience General Practice

Better awareness of how common influenza is and that most patients do not consult their GP when ill
Year(s) Of Engagement Activity 2007