Centre for molecular-based causal analyses in health and disease

Lead Research Organisation: University of Bristol
Department Name: Social Medicine

Abstract

Please see case for support, as advised by MRC head office

Technical Summary

The proposed MRC Centre for Molecular-based Causal Analyses in Health and Disease will integrate
evidence from cellular, animal, bio-informatic and large population based studies to determine
causal pathways of relevance to the aetiology, diagnosis, prognosis, progression and
treatment of disease. The anticipated output of the Centre will be knowledge that informs the
development and implementation of clinical and population based strategies to reduce morbidity and
mortality. Specification of causal associations between modifiable risk factors and disease will
determine the optimal interventions for preventing disease. Similarly, identifying causal associations
between modifiable risk factors and disease progression in patients will allow for estimation of
prognosis and determination of the most effective interventions for secondary prevention and
reversal of disease processes. Since biomarkers on causal pathways between disease initiation and
clinical presentation will provide useful diagnostic tools, the work of the Centre will also inform
means of diagnosing common pathologies at an early stage.
Our mission will be achieved through the translational integration of inter-disciplinary research
findings from cellular studies, animal models, bioinformatic investigations, data-mining approaches,
microarray expression data, and genotype and phenotype data from large-scale population-based
cohort studies, case-control studies and clinical cohorts. The elaboration and application of
appropriate data analysis methods that draw strength from all levels of evidence will complement
the collection and compilation of empirical data and will maximise the practical utility of research
findings.

Organisations

Publications

10 25 50

publication icon
Ahmed I (2011) False discovery rate estimation for stability selection: application to genome-wide association studies. in Statistical applications in genetics and molecular biology

 
Description (MJ Brion, Fellow) Public health consequences of modifiable maternal exposures: offspring obesity and cognitive health in two cohorts in the UK and Brazil
Amount £250,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start  
 
Description A Fraser(post doctoral fellow) Obstetric, lifestyle and genetic determinants of vascular and metabolic traits in women in early middle-age. MRC health services and health of the public research fellowship
Amount £336,579 (GBP)
Funding ID G0701594 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description A cluster randomised controlled trial of a primary school-based intervention to increase levels of physical activity, decrease sedentary behaviour and improve diet
Amount £1,464,457 (GBP)
Funding ID 09/3005/04 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description A genome based recall pilot study to compare use of liver enzymes, ultrasound scan and magnetic resonance imaging for identifying non-alcoholic fatty liver disease in epidemiological studies.
Amount £58,413 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description A graphical model approach to pedigree construction using constrained optimisation
Amount £446,718 (GBP)
Funding ID G1002312 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description A systems approach to the classification of genes impacting the cardiovascular phenome
Amount £310,320 (GBP)
Funding ID G1000427 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description A systems approach to the classification of genes impacting the cardiovascular phenome
Amount £310,320 (GBP)
Funding ID G1000427 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Accessible Resource for Integrated Epigenomics Studies
Amount £1,480,134 (GBP)
Funding ID BB/I025751/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description An examination of the association of maternal vitamin D status with abnormal glucose tolerance in pregnancy
Amount £51,473 (GBP)
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description An examination of the association of maternal vitamin D status with abnormal glucose tolerance in pregnancy.
Amount £51,473 (GBP)
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Behavioural and neurophysiological effects of schizophrenia risk genes
Amount £789,477 (GBP)
Funding ID MR/K004360/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Body weight and shape as determinants of risk of NAFLD in adults
Amount £349,873 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description Breastfeeding RCT: Adolescent Neurocognitive Respiratory Function
Amount £1,141,755 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start  
 
Description Bristol NIHR Biomedical Research Centre
Amount £20,858,545 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description British Heart Foundation Project Grant
Amount £130,493 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description British Heart Foundation Project grant
Amount £237,731 (GBP)
Funding ID Not known 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2011 
End 03/2014
 
Description British Women's Heart & Health Study: causes and consequences of cardiovascular disease.
Amount £308,528 (GBP)
Funding ID PG/09/022/26739 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description British Women's Heart & Health Study: the causes and consequences of cardiovascular disease in women
Amount £538,932 (GBP)
Organisation Department for Business, Energy & Industrial Strategy 
Sector Public
Country United Kingdom
Start  
 
Description C Gregson (Fellowship) Investigation of the epidemiology and heritability of high bone mass.
Amount £405,008 (GBP)
Organisation Wings for Life Spinal Cord Research Foundation 
Sector Private
Country Austria
Start  
 
Description CHICOS Developing a Child Cohort Research Strategy for Europe (1.5m euros across 9 participants)
Amount £135,767 (GBP)
Funding ID 241604 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description Characterisation of osteoarthritis phenoptype in a unique multi-centre cohort of individuals with extremely high bone mass
Amount £164,748 (GBP)
Funding ID 19580 
Organisation Versus Arthritis 
Start  
 
Description Colston Research Society Symposium: The New Genomics: Public Health, Social and Clinical Implications
Amount £5,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Department of Biotechnology, India (Genetic Association Study COPD genetics consortium)
Amount £326,737 (GBP)
Organisation Ministry of Science and Technology India 
Sector Public
Country India
Start  
 
Description Determining novel causal risk factors for CVD from early life to adulthood: An original genome-wide Mendelian Randomization approach
Amount € 350,000 (EUR)
Organisation Transatlantic Networks of Excellence in Cardiovascular Research Program 
Sector Academic/University
Country France
Start  
 
Description Development and evaluation of interventions for the prevention of childhood obesity in a multi-ethnic population: the Born in Bradford NHS Research Programme
Amount £1,999,300 (GBP)
Funding ID RP-PG-0407-10044 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description Developmental overnutrition, DNA methylation and offspring cardiovascular health
Amount £100,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Do epigenetic markers contribute to the excess risk of diabetes and coronary heart disease in Indian Asians?
Amount £196,086 (GBP)
Funding ID 082464/Z/07/C 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Do measures in blood cord predict long term offspring phenotype
Amount £497,019 (GBP)
Funding ID 094311 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Does mother's dietary intake during pregnancy influence offspring brain development and therefore cognitive ability?
Amount £167,061 (GBP)
Funding ID 084668 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Dysfunction of insulin signalling in type 2 diabetes and cardiovascular disease: a molecular and genetic pathway approach
Amount £258,834 (GBP)
Funding ID PG/10/008/28186 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description EU FP7 IRSES Genomic and Epigenomic Complex Disease Epidemiology
Amount £757,671 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description Early life determinants of blood pressure patterns in young adults
Amount £495,353 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start  
 
Description Epigenetic pathways to conduct problem trajectories: the role of prenatal and environmental risk exposures
Amount £1,100,000 (GBP)
Organisation National Institute of Child Health (NICH) 
Sector Hospitals
Country Pakistan
Start  
 
Description European Research Council Advanced Grant (Understanding health across the lifecourse: an integrated developmental approach)
Amount £2,162,020 (GBP)
Funding ID 269874 
Organisation European Research Council (ERC) 
Sector Public
Country European Union (EU)
Start  
 
Description Explaining the association between type 2 diabetes and coronary heart disease in older men and women using two linked epidemiological studies: ¬ the role of novel risk factors
Amount £84,075 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Exploiting SNP data in epidemiology and genetics through multivariate analysis of complex traits
Amount $460,517 (AUD)
Organisation National Health and Medical Research Council 
Sector Public
Country Australia
Start  
 
Description Fatty Liver: Inhibition of Progression (FLIP) programme (6m euros across 17 participants)
Amount £2,000,000 (GBP)
Funding ID 241762 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description Funding to establish a capacity building doctoral training centre populations, pathways and molecules: mathematical and statistical approaches (10 four (1+3) year Ph.D. studentships (BCSBmed).
Amount £823,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Galobardes B (Research Fellow) Wellcome Trust Intermediate Clinical Fellowship in life course inequalities in asthma: estimating its burden  and the understanding of its aetiology.
Amount £329,640 (GBP)
Funding ID 089979 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Genetic and epigenetic determinants of obesity in Inda
Amount £195,000 (GBP)
Funding ID 083541 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Genetic predictors of blood antioxidant levels and the risk of AMD
Amount £45,777 (GBP)
Organisation Macular Society 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Genetic risk factors for cardiovascular disease in the British Women's Heart and Health Study
Amount £163,757 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Genetic variation and gene-environmental influences in autistic-like traits
Amount £69,434 (GBP)
Organisation Autistica 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Genome-wide association study of maternal pregnancy phenotypes and later-life maternal and offspring vascular and metabolic phenotypes
Amount £2,306,620 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start  
 
Description Identification and Validation of Epigenetic Variation in ALSPAC.
Amount £155,905 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Identification of normal and at risk trajectories of blood pressure in rpegnancy in relation to offspring perinatal health and childhood development
Amount £345,701 (GBP)
Funding ID MR/J011932/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Inferring Epidemiological Causality using Mendelian Randomisation
Amount £476,228 (GBP)
Funding ID G0601625 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Jago R (Research fellow). Parental and home environment influences on youth physical activity and screen-viewing: Preventing childhood obesity. NIHR Career Development Fellowship
Amount £379,000 (GBP)
Funding ID CDF-2009-02-14 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description Joint UK Research Council Funded as part of the Lifelong Health and Wellbeing - Phase 3 initiative (The menopausal transition and healthy ageing and wellbeing)
Amount £1,502,949 (GBP)
Funding ID G1001357 
Organisation Research Councils UK (RCUK) 
Sector Public
Country United Kingdom
Start  
 
Description Lifelong Health and Wellbeing (joint UKRCs)
Amount £1,502,949 (GBP)
Funding ID G1001357 
Organisation Medical Research Council (MRC) 
Department MRC Regional Centre London
Sector Public
Country United Kingdom
Start 09/2011 
End 08/2016
 
Description Luisa Zuccolo (Post Doctoral  Research Fellow).  Prenatal alcohol exposure, childhood development and teenage drinking: a study of trans-generational effects.
Amount £417,352 (GBP)
Funding ID G0902144 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC Integrative Epidemoilogy Unit.
Amount £12,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2018 
End 03/2023
 
Description MRC Research grant (Mitochondrial DNA)
Amount £384,038 (GBP)
Funding ID MR/K002767/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2013 
End 05/2016
 
Description Mapping phenotypic to genetic variability in the High Bone Mass Study
Amount £355,425 (GBP)
Funding ID 20000 
Organisation Versus Arthritis 
Start 01/2013 
End 12/2018
 
Description Maternal thyroid status and offspring development
Amount £222,383 (GBP)
Funding ID ETM/97 
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start  
 
Description Measurement and modeling of functional trajectories across the life course (cross-unit appointments)
Amount £280,134 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Mitochondrial DNA copy number as a phenotypic trait for human diseases in genetic epidemiological studies
Amount £384,038 (GBP)
Funding ID MR/K002767/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Modifiable early life determinants of adolescent NAFLD and its association with metabolic and vascular traits
Amount £130,493 (GBP)
Funding ID PG/11/33/28794 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Molecular Epidemiology. Postdoctoral fellowships in molecular epidemiology.
Amount £840,000 (GBP)
Funding ID OCAY-12-325 
Organisation Oak Foundation 
Sector Charity/Non Profit
Country Global
Start  
 
Description Molecular, genetic and lifecourse epidemiology. PhD programme to provide 3 PhD students per year for 6 years.
Amount £2,900,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description NHMRC
Amount $674,010 (AUD)
Funding ID APP1043178 
Organisation National Health and Medical Research Council 
Sector Public
Country Australia
Start 01/2013 
End 12/2015
 
Description NIHR Public Health Research Programme (A cluster randomised controlled trial of a primary school-based intervention to increase levels of physical activity, decrease sedentary behaviour and improve diet)
Amount £1,464,457 (GBP)
Funding ID PHR/09/3005/04 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description Obstetric, lifestyle and genetic determinants of atherosclerosis, fat mass, insulin, glucose and lipid levels in early middle-age
Amount £882,350 (GBP)
Funding ID SP/07/008/24066 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Occurrence and determinants of adolescent Non-Alcoholic Fatty Liver Disease (NAFLD)
Amount £185,776 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description Overseas PhD studentship to Osama Al-Ghamdi
Amount £80,700 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description PROACTIV: PaRental influences On physical ACTIVity and screen viewing in young children
Amount £237,731 (GBP)
Funding ID PG/11/51/28986 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Pregnancy changes and future health of mother and offspring
Amount £64,650 (GBP)
Funding ID WT094529MA 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2012 
End 06/2013
 
Description Pregnancy changes and future health of mother and offspring
Amount £64,650 (GBP)
Funding ID WT094529MA 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description R Freathy -Metzger BE, Cox NJ. Maternal and offspring genetics in fetal and childhood growth. Wellcome Trust (Sir Henry Wellcome Postdoctoral Fellowship)
Amount £250,000 (GBP)
Funding ID 085541 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description RES-060-23-0011 An examination of the impact of family socio-economic status on outcomes in late childhood and adolescence
Amount £3,604,228 (GBP)
Funding ID ES/E00234X/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start  
 
Description Santos AC (Postdoctoral Research Fellow). Desenvolvimento da obesidade na infância (Development of obesity in infancy). €225,000/Portugese Research Council
Amount £225,000 (GBP)
Organisation New University of Lisbon 
Department Foundation for Science and Technology
Sector Academic/University
Country Portugal
Start  
 
Description Self-harm with and without suicidal intent in adolescence: causes and consequences - the ALSPAC cohort
Amount £211,248 (GBP)
Funding ID MR/J012661/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Smoking, DNA methylation at F2RL3 and cardiovascular disease risk
Amount £15,540 (GBP)
Organisation University of Bristol 
Department MRC Centre for Causal Analyses in Translational Epidemiology
Sector Public
Country United Kingdom
Start 12/2012 
End 08/2013
 
Description Socioeconomic inequalities in cardiovascular disease risk over the life course and in different generations
Amount £380,000 (GBP)
Organisation Research Council of Norway 
Sector Public
Country Norway
Start  
 
Description Socioeconomic inequalities in cardiovascular disease risk over the life course and in different generations
Amount £360,000 (GBP)
Organisation Research Council of Norway 
Sector Public
Country Norway
Start 07/2012 
End 06/2015
 
Description Specific project: datamining developments to identify members of a newly defined category of QTLs: splice-translational efficiency polymorphisms (STEPS), (capacity building studentship in bioinformatics)
Amount £79,012 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Stability and integrity of microbiome sampling
Amount £24,150 (GBP)
Organisation University of Bristol 
Department MRC Centre for Causal Analyses in Translational Epidemiology
Sector Public
Country United Kingdom
Start 12/2012 
End 08/2013
 
Description The 1958 Birth Cohort Biomedical Resource - faciliating access to data and samples and enhancing future utility
Amount £1,489,639 (GBP)
Funding ID G1001799 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description The Genetic Epidemiology of Atopic Dermatitis
Amount £477,733 (GBP)
Funding ID MR/J012165/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description The Healing Foundation UK Cleft Gene Bank
Amount £2,396,169 (GBP)
Organisation University of Manchester 
Department Healing Foundation (Charity for people with disfigurement and visible loss of function)
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description The causal role of the nutritionally regulated insulin-like growth factor system in prostate cancer: Mendelian randomization study
Amount £224,387 (GBP)
Funding ID 2011/419 
Organisation World Cancer Research Fund 
Sector Charity/Non Profit
Country Global
Start  
 
Description The contribution of maternal obesity and gestational weight gain to preschool child obesity. Long-term follow-up of the LIMIT RCT.
Amount $1,700,000 (AUD)
Organisation National Health and Medical Research Council 
Sector Public
Country Australia
Start  
 
Description The long-term effects of increased alcohol availability: a natural experiment.
Amount 4,030,000 kr (SEK)
Organisation Government of Sweden 
Sector Public
Country Sweden
Start 01/2013 
End 12/2016
 
Description The menopausal transition and healthy ageing and wellbeing
Amount £1,502,949 (GBP)
Funding ID G1001357 
Organisation Medical Research Council (MRC) 
Department Lifelong Health and Wellbeing (LLHW)
Sector Public
Country United Kingdom
Start  
 
Description The public health importance of vitamin D: the causal effect of intrauterine and lifetime exposure to vitamin D on metabolic and vascular traits
Amount £1,382,920 (GBP)
Funding ID G0701603 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description The relationship of the menopausal transition to healthy ageing and chronic disease risk
Amount £1,226,786 (GBP)
Funding ID WT092830M 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description The utility of biomarkers for non-alcoholic fatty liver disease in adolescents
Amount £548,636 (GBP)
Funding ID G0801456 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2009 
End 09/2012
 
Description Twins UK (2012-2015) - An Epidemiological and Genomic resource
Amount £1,500,000 (GBP)
Funding ID 099194 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Using Mendelian Randomisation to Establish the Causal Role of Cigarette Smoking in Anxiety and Depression
Amount £110,594 (GBP)
Funding ID MR/J01351X/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Validation and Replication of Variants in Predicted microRNA Binding Sites and their Effect on mRNA Expression Levels.
Amount £14,516 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Vitamin D as a (causal) determinant of insulin resistance and diabetes? An analysis of three UK based prospective studies
Amount £195,540 (GBP)
Funding ID 10/0004071 
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Vitamin D as a (causal) determinant of insulin resistance and diabetes? An analysis of three UK based prospective studies.
Amount £195,540 (GBP)
Funding ID 10/0004071 
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description WT Resource award B638 SSCM.RJ5193 'ALSPAC: Request for funds to enhance this detailed biomedical resource with obstetric & perinatal data from medical records'
Amount £121,384 (GBP)
Funding ID 087997 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2011
 
Description Wellcome Trust Resources Award
Amount £1,481,389 (GBP)
Funding ID WT101597MA 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2014 
End 01/2018
 
Description Wellcome Trust call for Genome Wide Association Studies (Genome-wide association study of maternal pregnancy phenotypes and later-life maternal and offspring vascular and metabolic phenotypes)
Amount £2,028,579 (GBP)
Funding ID 088806 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description 25(OH)D GWAS in children 
Organisation University of Queensland
Department Genetic Epidemiology Laboratory
Country Australia 
Sector Public 
PI Contribution We are leading this collaboration which includes teams from Australia (QIMR and Perth) and the US (NHANES) who are working with us to identify genetic variants associated with 25(OH)D, calcuim, phosphate and PTH in children.
Collaborator Contribution Replication sample for our GWAS, which will be published Replication of our GWAS analysis, which will be published
Impact Draft first publication currently being circulated amongst co-authors. The collaboration is multidisciplinary including epidemiologists, statisticians, geneticists and bioinformaticians.
Start Year 2010
 
Description 25(OH)D GWAS in children 
Organisation University of Western Australia
Department School of Population Health
Country Australia 
Sector Academic/University 
PI Contribution We are leading this collaboration which includes teams from Australia (QIMR and Perth) and the US (NHANES) who are working with us to identify genetic variants associated with 25(OH)D, calcuim, phosphate and PTH in children.
Collaborator Contribution Replication sample for our GWAS, which will be published Replication of our GWAS analysis, which will be published
Impact Draft first publication currently being circulated amongst co-authors. The collaboration is multidisciplinary including epidemiologists, statisticians, geneticists and bioinformaticians.
Start Year 2010
 
Description A review of life time risk factors for mortality 
Organisation University College London
Department Centre for Longitudinal Studies
Country United Kingdom 
Sector Academic/University 
PI Contribution Aim to review evidence for risk factors for mortality across the life time using evidence from existing birth cohorts. Two leads, one Bristol.
Impact Journal publication accepted Biomedical leads for Joint Forces conference on Mortality & Longevity.
Start Year 2009
 
Description A review of life time risk factors for mortality 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution Aim to review evidence for risk factors for mortality across the life time using evidence from existing birth cohorts. Two leads, one Bristol.
Impact Journal publication accepted Biomedical leads for Joint Forces conference on Mortality & Longevity.
Start Year 2009
 
Description ANDIPOGEN 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Analytical and methodological, through the organisation and undertaking of analyses concerning the genetics of adiponectin levels.
Collaborator Contribution Development of sample collections for the extended analysis of the genetics of circulating adiponectin.
Impact Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, Perry JR et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genetics 2009 5:e1000768. Heid IM, Henneman P, Hicks A, Coassin S, Winkler T, Aulchenko YS et al. Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis 2010;208:412-20. EGG/EAGLE Sovio U, Bennett AJ, Millwood IY, Molitor J, O'Reilly PF, Timpson NJ et al. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. PLoS Genet 2009;5:e1000409. Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ et al. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics. 2010;42:430-5. Sovio U, Mook-Kanamori D, Warrington N, Lawrence R, Briollais L, Palmer C, et al. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: The complex nature of genetic association through growth and development. PLoS Genetics 2010; 7(2):e1001307.
Start Year 2009
 
Description ARIES (Accessible Resource for Integrated Epidemiological Studies) 
Organisation The International Centre for Life
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution CAiTE leads this collaboration.
Collaborator Contribution Data sharingData sharing
Impact The project began quite recently, so none so far.
Start Year 2011
 
Description ARIES (Accessible Resource for Integrated Epidemiological Studies) 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution CAiTE leads this collaboration.
Collaborator Contribution Data sharingData sharing
Impact The project began quite recently, so none so far.
Start Year 2011
 
Description Adolescent onset conduct problems: a biopsychosocial model of risk. 
Organisation King's College London
Department MRC Social Genetic and Developmental Psychiatry Centre (SDGP)
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of Genetic information and data
Impact Publications
Start Year 2009
 
Description Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study 
Organisation Icelandic Heart Association (IHA)
Country Iceland 
Sector Charity/Non Profit 
PI Contribution We designed the study, conducted all statistical analyses and drafted a manuscript.
Collaborator Contribution They made available to us DNA from AGES participants for SNP genotyping. They made also available to us a large number of phenotypes including Hemoglobin A1c, height, weight, body mass index (BMI, defined as weight (kg)/height squared (m2)), waist circumference, fat free mass (measured by bioimpedence), systolic blood pressure, diastolic blood pressure, fasting glucose, fasting insulin, cholesterol, HDL, LDL, triglycerides and coronary calcium. Blood pressure and anthropometric data included BMI, waist circumference and fat-free mass. Fasting blood glucose, total cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides. Fasting insulin and two binary traits, hypertension and type 2 diabetes.
Impact Santiago Rodriguez, Gudny Eiriksdottir, Tom R. Gaunt, Tamara B. Harris, Lenore J. Launer, Vilmundur Gudnason, Ian N. M. Day. 2010. IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetes. Growth Hormone & IGF Research 20: 310-318.
Start Year 2007
 
Description An investigation of genetic epidemiological risk factors for psychotic like symptoms in adolescent birth cohort. 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution ????
Impact Publication
 
Description Association of maternal diabetes genes with offspring adiposity as a test of the developmental overnutrition hypothesis 
Organisation Danish Ministry of Health
Department Danish National Birth Cohort
Country Denmark 
Sector Public 
PI Contribution Analyses completed in ALSPAC. Key aims of the project are to examine independent (of offspring genotype) associations of maternal type 2 diabetes related genetic variants with offspring weight, BMI, waist and fat mass in infancy and childhood
Impact Paper due for submission imminently.
Start Year 2008
 
Description Association of maternal diabetes genes with offspring adiposity as a test of the developmental overnutrition hypothesis 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Analyses completed in ALSPAC. Key aims of the project are to examine independent (of offspring genotype) associations of maternal type 2 diabetes related genetic variants with offspring weight, BMI, waist and fat mass in infancy and childhood
Impact Paper due for submission imminently.
Start Year 2008
 
Description Association of maternal diabetes genes with offspring adiposity as a test of the developmental overnutrition hypothesis 
Organisation Norwegian National Birth Cohort
Country Norway 
Sector Public 
PI Contribution Analyses completed in ALSPAC. Key aims of the project are to examine independent (of offspring genotype) associations of maternal type 2 diabetes related genetic variants with offspring weight, BMI, waist and fat mass in infancy and childhood
Impact Paper due for submission imminently.
Start Year 2008
 
Description Association of maternal diabetes genes with offspring adiposity as a test of the developmental overnutrition hypothesis 
Organisation University of Exeter
Department College of Social Sciences and International Studies
Country United Kingdom 
Sector Academic/University 
PI Contribution Analyses completed in ALSPAC. Key aims of the project are to examine independent (of offspring genotype) associations of maternal type 2 diabetes related genetic variants with offspring weight, BMI, waist and fat mass in infancy and childhood
Impact Paper due for submission imminently.
Start Year 2008
 
Description Association of maternal diabetes genes with offspring adiposity as a test of the developmental overnutrition hypothesis 
Organisation University of Western Australia
Department Raine Medical Research Foundation
Country Australia 
Sector Academic/University 
PI Contribution Analyses completed in ALSPAC. Key aims of the project are to examine independent (of offspring genotype) associations of maternal type 2 diabetes related genetic variants with offspring weight, BMI, waist and fat mass in infancy and childhood
Impact Paper due for submission imminently.
Start Year 2008
 
Description Born in Bradford 
Organisation Bradford Institute for Health Research (BIHR)
Country United Kingdom 
Sector Academic/University 
PI Contribution We are collaborating with the Born in Bradford cohort to examine the association of maternal 25(OH)D in pregnancy with pregnancy complications.
Collaborator Contribution Advances understanding of the relationship of 25(OH)D to pregnancy complications. Output includes research journal publications.
Impact Two papers are currently at advanced darft status. One examines associations with results from oral glucose tolerance tests in pregnancy and the second with hypertensive disorders of pregnancy.
Start Year 2010
 
Description Bristol CaRE collaboration 
Organisation National Heart, Lung, and Blood Institute (NHLBI)
Department Candidate gene Association Resource (CARe)
Country United States 
Sector Academic/University 
PI Contribution Data sharing within consortium.
Collaborator Contribution Data sharing within consortium.
Impact Disciplines: Statistical genetics, Genetic epidemiology, Molecular Genetics, Bioinformatics. Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, M Maloney C, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou C, Boer A, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, J Meyer N, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszweski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmuda JM, Clarke R, Balmforth AJ, Danesh J, Day IN, Schork NJ, de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, D Christie J, Berenson GS, Murray SS, Illig T, Dorn GW 2nd, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, Marz W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ; Hugh Watkins on behalf of PROCARDIS; Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT; Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group; Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet. 2011 Jan 7;88(1):6-18. Epub 2010 Dec 30.
Start Year 2010
 
Description C-Reactive Protein Coronary Heart Disease Genetics Collaboration ( 
Organisation University of Cambridge
Department Department of Public Health and Primary Care
Country United Kingdom 
Sector Academic/University 
PI Contribution Involved in the establishment of the collaboration Intellectual contribution to all papers Contribution of data and analyses from cohorts maintained at University of Bristol
Collaborator Contribution Sharing of intellectual ideas, expertise and data
Impact Three papers published and others currently on going. 1. Danesh J, Hingorani A, Wensley F, Casas JP, Smeeth L, Samani NJ, Hall A, Whincup P, Morris R, Lawlor DA, Davey Smith G, Timpson NJ, Ebrahim S, Brown M, Sandhu M, Reiner A, Psaty B, Lange L, Cushman M, Tracy R, Nordestgaard BG, Tybjaerg-Hansen A, Zacho J, Hung J, Thompson P, Beilby J, Palmer LJ, Fowkes, Lowe G, Tzoulaki I, Kumari M, Overvad K, Khaw KT, Benjamin E, Chiodini B, Franzosi M, Norman PE, Hankey GJ, Jamrozik K, Rimm E, Pai J, Psaty B, Heckbert S, Bis J, Yusuf S, Anand S, Engort J, Collins R, Melander O, Berglund G, Ladenvall P, Johansson L, Jansson J-H, Hallmans G, Humphries S, Manson J, Saleheen D, Danesh J, Frossard P, Sattar N, Robertson M, Shepherd J, Schaefer E, Hofman A, Witteman JCM, Kardys I, de Faire U, Bennet A, O'Reilly D, McMahon A, Packard C, Clarke R, Kumari M, Greenland P, Manson J, Casas JP, Franzosi M, Nordestgaard BG, Smeeth L, Bowden J, Di Angelantonio E, Shah T, Thompson S, Verzilli C, Walker M, Whittaker J, Yusuf S. Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomization. European Journal of Epidemiology 2008;23:531-540 2. Burgess S, Thompson SG, Andrews G, Samani NJ, Hall A, Whincup P, Morris R, Lawlor DA, Davey Smith G, Timpson N, Ebrahim S, Ben-Shlomo Y, Brown M, Ricketts S, Sandhu M, Reiner A, Psaty B, Lange L, Cushman M, Hung J, Thompson P, Beilby J, Warrington N, Palmer LJ, Nordestgaard BG, Tybjaerg-Hansen A, Zacho J, Wu C, Lowe G, Tzoulaki I, Kumari M, Sandhu M, Yamamoto JF, Chiodini B, Franzosi M, Hankey GJ, Jamrozik K, Palmer L, Rimm E, Pai J, Heckbert S, Bis J, Anand S, Engert J, Collins R, Clarke R, Melander O, Berglund G, Ladenvall P, Johansson L, Jansson JH, Hallmans G, Humphries S, Manson J, Watkins H, Clarke R, Hopewell J, Saleheen D, Frossard R, Sattar N, Robertson M, Shepherd J, Schaefer E, Hofman A, Witteman JC, Kardys I de Faire U, Bennet A, Ford I, Packard C, Casas JP, Smeeth L, Wensley F, Bowden J, Di Angelantonio E, Engert J, Gao P, Shah T, Verzilli C, Walker M, Whittaker J, Hingorani A, Danesh J. Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables. Statistics in Medcine 2010; 29:1298-1311 3. C-Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC). Is C-reactive protein causally related to coronary heart disease? Mendelian randomization analyses based on individual participant data. BMJ 2010; in press
Start Year 2008
 
Description CHICOS 
Organisation CHICOS: Developing a Child Cohort Research Strategy for Europe
Country European Union (EU) 
Sector Academic/University 
PI Contribution Overall aim is to improve child health across Europe by developing an integrated strategy for mother-child cohort research in Europe. Methodologically we are working on ways of harmonising data and comparing results between and, where appropriate, pooling data from all European mother-child cohorts. I lead the work on child obesity and cardiometabolic health. I contribute data and/or analyses results for reserach that other partners lead in other research areas.
Collaborator Contribution Partners contribute data or results from analyses for research that I lead on child obesity and cariometabolic health.
Impact Publications currently being drafted
Start Year 2010
 
Description Comparing associations of SEP with change in height from birth to age 9 between a LMIC and HIC cohort 
Organisation Federal University of Pelotas (UFPel)
Department 1982 Pelotas Birth Cohort
Country Brazil 
Sector Academic/University 
PI Contribution Aim to compare the assocations of socioeonomic position with growth in lenght/height between birth and age 9. Bristol led.
Impact Two papers with each cohort, but referring to each other at end, at almost final draft stage.
Start Year 2008
 
Description Comparing growth in cohorts from LMIC and HIC 
Organisation Federal University of Pelotas (UFPel)
Department 1982 Pelotas Birth Cohort
Country Brazil 
Sector Academic/University 
PI Contribution Aim to compare childhood growth curves for height and weight (from birth to age 9) between countries with very different socioeconomic backgrounds. Lead by ALSPAC
Collaborator Contribution Provision of data
Impact Analyses within each cohort complete, paper being drafted.
Start Year 2008
 
Description Copenhagen Heart Study 
Organisation Copenhagen University Hospital
Country Denmark 
Sector Hospitals 
PI Contribution Key contribution in the analysis of data and the writing of research papers pertaining to the undertaking of causal analyses. This has included research papers on blood pressure and BMI, depression, C-reactive protein and BMI.
Collaborator Contribution A huge population based repository of epidemiological and clinical data which has been a crucial contribution to the undertaking and development of Mendelian randomisation studies.
Impact Timpson NJ, Nordestgaard BG, Harbord RM, Zacho J, Frayling TM, Tybjaerg-Hansen A, et al. C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. Int J Obesity 2010, doi: 10.1038/ijo.2010.137. Timpson NJ, Harbord R, Davey Smith G, Zacho J, Tybjaerg-Hansen, Nordestgaard BG. Does Greater Adiposity Increase Blood Pressure And Hypertension Risk? Mendelian Randomization Using Fto/Mc4r Genotype. Hypertension 2009; 54: 84-90. Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53 221 adults. Debbie A. Lawlor1,2, Roger M. Harbord2,1, Anne Tybjaerg-Hansen3,4,5, Tom M. Palmer1,2, Jeppe Zacho4,5,6, Marianne Benn4,5,6, Nicholas J. Timpson1,2, George Davey Smith1,2 & Børge G. Nordestgaard4,5,6 doi: 10.1111/j.1365-2796.2011.02343.x 2011 The Association for the Publication of the Journal of Internal Medicine 525
Start Year 2008
 
Description Developing family based methods for causal analysis in life course epidemiology 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution Aim to review, develop and document the theoretical underpinning and statistical methods for using family based studies to improve causal inference in life course epidemiology. Bristol lead
Impact Family matters - designing, analysing and understanding family-based studies in life course epidemiology (OUP 2009). Several workshops
Start Year 2007
 
Description Developing family based methods for causal analysis in life course epidemiology 
Organisation University of Aberdeen
Department Institute of Applied Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Aim to review, develop and document the theoretical underpinning and statistical methods for using family based studies to improve causal inference in life course epidemiology. Bristol lead
Impact Family matters - designing, analysing and understanding family-based studies in life course epidemiology (OUP 2009). Several workshops
Start Year 2007
 
Description Diet in relation to increasing body fatness in childhood. 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of data
Impact Publications
 
Description Diet, IGF and cancer risk: an inter-generational investigation. 
Organisation University of Bristol
Department School of Social and Community Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of Dietary information and blood samples from Mothers and children.
Impact Publications.
 
Description Disordered eating in adolesence: a longitudinal study of risk factors 
Organisation King's College London
Department Institute of Psychiatry, Psychology & Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of data
Impact Publications and Phd project
Start Year 2006
 
Description EGG/EAGLE 
Organisation University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Contribution to the development and running of the consortium along with leading a series of core projects for this consortium - including the longitudinal analysis of genetic effects on BMI, eczema, sensitisation and allergy, etc.
Collaborator Contribution Development of the largest base of paediatric samples with gwas data for the analysis and exploration of the genetics of growth, development and child base epidemiology.
Impact Sovio U, Bennett AJ, Millwood IY, Molitor J, O'Reilly PF, Timpson NJ et al. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. PLoS Genet 2009;5:e1000409. Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ et al. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics. 2010;42:430-5. Sovio U, Mook-Kanamori D, Warrington N, Lawrence R, Briollais L, Palmer C, et al. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: The complex nature of genetic association through growth and development. PLoS Genetics 2010; 7(2):e1001307.
Start Year 2008
 
Description Examing the causal effects of breast feeding on IQ, obesity and blood pressure 
Organisation Federal University of Pelotas (UFPel)
Department 1982 Pelotas Birth Cohort
Country Brazil 
Sector Academic/University 
PI Contribution To examine the role of cross-cohort comparisons for dealing with confounding and improving causal inference using breast-feeding and later outcomes as an example. Lead by ALSPAC
Impact Paper under review
Start Year 2008
 
Description Examining the causal association of maternal adiposity in pregnancy with offspring cognition & behaviour 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Aim is to compare different methods of examining causality and determine whether variation in maternal BMI in pregnancy is related to offspring cognitive function and behaviours. Led by ALSPAC
Impact Advanced draft with co-authors
Start Year 2009
 
Description Examining the causal association of maternal adiposity in pregnancy with offspring cognition & behaviour 
Organisation Federal University of Pelotas (UFPel)
Department 1982 Pelotas Birth Cohort
Country Brazil 
Sector Academic/University 
PI Contribution Aim is to compare different methods of examining causality and determine whether variation in maternal BMI in pregnancy is related to offspring cognitive function and behaviours. Led by ALSPAC
Impact Advanced draft with co-authors
Start Year 2009
 
Description Functional trajectories Across the Life Course (FALCon) 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution Aim is to develop methods for describing functional trajectories across life course from birth to age 90s and exploring the determinants of these by using UK cohorts that cover different time periods in the life course. Joint Bristol/ lead
Impact MRC funded project grant. 4 papers submitted and 3 conference presentations.
Start Year 2007
 
Description GBPGen - Global BP Genome Wide Collaboration 
Organisation Queen Mary University of London
Department Barts and The London School of Medicine and Dentistry
Country United Kingdom 
Sector Academic/University 
PI Contribution study design, analysis and paper writing
Collaborator Contribution Sharing of intellectual ideas, data and analyses
Impact Papers:- 1) Common variation in the WNK1 gene and blood pressure in childhood: evidence from the Avon Longitudinal Study of Parents and Children. Hypertension 2008; 52:974-979. doi: 10.1161/hybertensioaha.108.118414, PMID:18809789. 2. The International Collaboration for Blood Pressure Genome-wide Association Studies. Common Polymorphisms Impacting Blood Pressure and Cardiovascular Disease in Diverse Populations Highlight Novel Biological Pathways. Nature Genetics 2010 (in press
Start Year 2008
 
Description GEoCoDE 
Organisation European Commission
Country European Union (EU) 
Sector Public 
PI Contribution CAiTE leads GEoCoDE.
Collaborator Contribution Data sharing
Impact 1. G Davey Smith, L Molloy, SM Ring, AR Ness, J MacLeod, D Evans, A Emond, G Lewis, K Tilling, J Donovan, J Tobias, B Glaser, R Burton, CL Relton, N Timpson, AJ Henderson, L Peltonen, J Lynch. The Avon Longitudinal study of parents and children: An international resource for population genomics and lifecourse epidemiology core programme support. Jan 2011-Dec 2013 MRC & Wellcome Trust 2. DA Lawlor, S Nelson, N Sattar, K Tilling, J Tobias, CL Relton, A Owen-Smith, J Donovan, D Kuh, SM Ring, G Davey Smith, C Propper, S Smith, I Beesley, A Fraser. The menopausal transition and healthy ageing and wellbeing. Joint UK Research Council funded as part of the Lifelong Health and Wellbeing - Phase 3 initiative. Sep 2011-Sep 2016 3. DA Lawlor, A Fraser, G Davey Smith, K Tilling, J Tobias, SM Ring, S Nelson, N Sattar, CL Relton, TM Palmer. The relationship of the menopausal transition to healthy ageing and chronic disease risk. May 2011-Apr 2015 Wellcome Trust 4. G Davey Smith, CL Relton, SE Ozanne, T Gaunt, SM Ring, D Evans, A Wipat, T Kirkwood, W Reik. ARIES - Accessible Resource for Integrated Epigenomic Studies. Sep 2011-Aug 2013 BBSRC 6. L Zuccolo. Prenatal alcohol exposure, childhood development and teenage drinking: a study of transgenerational effects. Sep 2010-Aug 2014 MRC Postdoctoral Fellowship, [Relton, Sponsor] 2. Relton CL, Davey Smith G. Future potential for the application of epigenetics in the prevention and treatment of common complex disease. PLoS Med 7(10):e1000356, 2010. 5. Timofeeva M, McKay JD, Davey Smith G, Johansson M, Byrnes G, Chabrier A, Relton CL, Ueland PM, Vollet SE, Midttun Ø, Nygård O, Slimani N, Boffetta P, Clavel-Chapelon F, Boutron-Ruault MC,Fagherazzi G, Kaaks R, Teucher B, Boeing H, Weikert C, Bueno-de-Mesquita HB, van Gils C, Peeters PHM, Agudo A, Barricarte A, Huerta JM, Rodríguez L, Sánchez MJ, Larrañaga N, Khaw KT, Wareham N, Allen NE, Travis RC, Gallo V, Norat T, Krogh V, Masala G, Panico S, Sacerdote C, Tumino R, Trichopoulou A, Lagiou P, Trichopoulos D, Rasmuson T, Hallmans G, Riboli E, Vineis P, Brennan P. Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels and risk of lung cancer in EPIC. Cancer Epidemiol Biomarkers Prev 2011, In Press. 6. Brion MJ, Lawlor DA, Matijasevich A, Horta BL, Anselmi L, Araújo CL, Menezes AM, Victora CG, Davey Smith G. What are the causal effects of breastfeeding on IQ, obesity and blood pressure? Evidence from comparing high-income with middle-income cohorts. Int J Epidemiol, In Press 7. Brion MJ, Victora CG, Matijasevich A, Horta BL, Anselmi L, Steer C, Menezes AM, Lawlor DA, Davey Smith G. Maternal smoking and child psychological problems: disentangling causal and noncausal effects. Pediatrics. 2010 Jul;126(1):e57-65. 16. Timpson NJ, Forouhi NG, Brion M-J, Harbord RM, Cook DG, Johnson P, McConnachie A, Morris RW, Rodriguez S, Luan J, Ebrahim S, Padmanabhan S, Watt G, Bruckdorfer KR, Wareham NJ2, Whincup PH, Chanock S, Sattar N, Lawlor DA, Davey Smith G. Genetic variation at the SLC23A1 locus is associated with circulating levels of Lascorbic acid (Vitamin C). Evidence from 5 independent studies with over 15000 participants. American Journal of Clinical Nutrition 2010;92:375-382. 17. Kinra S, Bowen LJ, Lyngdoh T, Prabhakaran D, Reddy KS, Ramakrishnan L, Gupta R, Bharathi AV, Vaz M, Kurpad AV, Davey Smith G, Ben-Shlomo Y, Ebrahim S. Sociodemographic patterning of non-communicable disease risk factors in rural India: a cross-sectional study. BMJ 2010;341:c4974. doi:10.1136/bmj.c4974. 18. Matijasevich A, Victora CG, Lawlor DA, Golding J, Menezes AMB, Araújo CL, Barros AJD, Santos IS, Barros FC, Davey Smith G. Association of socioeconomic position with maternal pregnancy and infant health outcomes in birth cohort studies from Brazil and the UK. Journal of Epidemiology and Community Health 2010 on line. doi:10.1136/jech.2010.108605. 19. Timpson NJ, Nordestgaard BG, Harbord RM, Zaccho J, Frayling TM, Tybjaerg-Hansen A, Davey Smith G. C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. International Journal of Obesity 2011; 35, 300-308. 20. Davies NM, Windmeijer F, Martin RM, Abdollahi MR, Davey Smith G, Lawlor DA, Ebrahim S, Day INM. Use of genotype frequencies in medicated groups to investigate prescribing: APOE and statins as a proof of principle. Clinical Chemistry 2010; on line. DOI: 10.1373/clinchem.2010.156356. 21. Ebrahim S, Kinra S, Bowen L, Andersen E, Ben-Shlomo Y, Lyngdoh T, Ramakrishnan L, Ahuja RC, Joshi P, Mohan Das S, Mohan M, Davey Smith G, Prabhakaran D, Reddy KS, for the Indian Migration Study Group. The Effect of Rural-to-Urban Migration on Obesity and Diabetes in India: A Cross-Sectional Study. PLoS Medicine 2010;7: DOI: e1000268. 22. Munafo MR, Freathy RM, Ring SM, St Pourcain B, Davey Smith G. Association of COMT Val108/158 MET Genotype and cigarette smoking in pregnant women. Nicotine and Tobacco Research 2010, doi: 10.1093/ntr/ntq209. 23. Brion M-J, Zeegers M, Jaddoe V, Verhulst F, Tiemeier H, Lawlor DA, Davey Smith G. Intrauterine effects of maternal prepregnancy overweight on child cognition and behaviour in 2 cohorts. Pediatrics 2011;127:e202-e211. 24. De Silva NMG , Freathy RM, Palmer TM, Donnelly LA, Luan J, Gaunt T, Langenberg C,, Weedon MN, Shields B, Knight BA, Ward K, Sandhu MS, Harbord RM, McCarthy MI, Davey Smith G, Ebrahim S, Hattersley AT, Wareham N, Lawlor DA, Morris AD, Palmer CNA, Frayling TM. Mendelian Randomization Studies do not Support a Role for Raised Circulating Triglyceride Levels influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance. Diabetes 2011, doi: 10.2337/db10-1317. 25. Barker A, Sharp SJ, Timpson NJ, Bouatia-Naki N, Warrington NM, Kanoni S, Beilin LJ, Brage S, Deloukas P, Evans DM, Grantved A, Hassanali N, Lawlor DA, Lecoeur C, Loos RJF, Lye SJ, McCarthy MI, Mori TA, Ndiaye NC, Newnham JP, Ntalla I, Pennell CE, St Pourcain B, Prokopenko I, Ring SM, Sattar N, Visvikis-Siest S, Dedoussis GV, Palmer LJ, Froguel P, Davey Smith G, Ekelund U, Wareham NJ, Langenberg C. Association of genetic loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes 2011, doi: 10.2337/db10-1575. 26. Sovio U, Mook-Kanamori DO, Warrington NM, Lawrence R, Briollais L, Palmer CNA, Cecil J, Sandling JK, Syvänen AC, Kaakinen M, Beilin LJ, Millwood IY, Bennett AJ, Laitinen J, Pouta A, Molitor J, Davey Smith G, Ben-Shlomo Y, Jaddoe VWV, Palmer LJ, Pennell CE, Cole TJ, McCarthy MI, Järvelin MR, Timpson NJ for the EGG Consortium. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: The complex nature of genetic association through growth and development. PLoS Genetics 2011, February; 7(2): e1001307; doi:10.1371/journal.pgen.1001307 27. Zabaneh D, Gaunt TR, Kumari M, Drenos F, Shah S, Berry D, Power C, Hypponen E, Shah T, Palmen J,Pallas J, Talmud PJ, Casas JP, Sofat R, Lowe G, Rumley A, Morris RW, Whincup PH, Rodriguez S, Ebrahim S, Marmot MG, Davey Smith G, Lawlor DA. Genetic Variants associated with von Willebrand Factor Levels in Health Men and Women Identified Using the Human CVD BeadChip. Annuals of Human Genetics 2011;75:456-467. 28. Kinra S, Andersen E, Ben-Shlomo Y, Bowen L, Lyngdoh T, Prabhakaran D, Reddy KS, Ramakrishnan L, Bharathi A, Vaz M, Kurpad A, Davey Smith G, Ebrahim S. Association between urban life-years and cardio-metabolic risk. Am J Epidemiol 2011, in press. 29. Taylor AE, Sandeep MN, Janipalli C, Giambartolomei C, Evans D, Kranthi Kumar MV, Vinay DG, Smitha P, Gupta V, Aruna M, Kinra S, Sullivan R, Bowen L, Timpson N, Davey Smith G, Dudbridge F, Prabhakaran D, Ben-Shlomo Y, Reddy KS, Ebrahim S. Associations of FTO and MC4R variants with obesity traits in Indians and the role of rural/urban environment as a possible effect modifier, Journal of Obesity 2011; doi:10.1155/2011/307542 30. Soler Artigas M, Wain LV, Repapi E, Obeidat M, Sayers I, Burton PR, Johnson T, Zhao JH, Albrecht E, Dominiczak AF, Kerr SM, Smith BH, Cadby G, Hui J, Palmer LJ, Hingorani AD, Wannamethee SG, Whincup PH, Ebrahim S, Davey Smith G, Barroso I, Loos RJL, Wareham NJ, Cooper C, Dennison E, Shaheen SO, Liu JZ, Marchini J, The NSHD Respiratory Study Team, Dahgam S, Naluai AT, Olin A-C, Karrasch S, Heinrich J, Schulz H, McKeever TM, Pavord ID, Heliövaara M, Ripatti S, Surakka I, Blakey JD, Kähönen M, Britton JR, Nyberg F, Holloway JW, Lawlor DA, Morris RW, James AL, Jackson CM, Hall IP, Tobin MD, and SpiroMeta Consortium. Effect of 5 Genetic Variants Associated with Lung Function on the Risk of COPD, and their Joint Effects on Lung Function. American Journal of Respiratory and Critical Care Medicine 2011, doi:10.1164/rccm.201102-0192OC 31. Freathy RM, Kazeem GR, Morris RW, Johnson PCD, Paternoster LP, Ebrahim S, Hattersley AT, Hill A, Hingorani AD, Holst C, Jefferis BJ, Kring SII, Mooser V, Padmanabhan S, Preisig M, Ring SM, Sattar N, Upton MN, Vollenweider P, Waeber G, Sørensen TIA, Frayling TM, Watt G, Lawlor DA, Whincup PH, Tozzi F, Davey Smith G, Munafò M. Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence BMI. International Journal of Epidemiology 2011; doi:10.1093/ije/dyr077 41. A.E. Taylor, M. N. Sandeep, C. S. Janipalli, C. Giambartolomei, D. M. Evans, M. V. Kranthi Kumar, D. G. Vinay, P. Smitha, V. Gupta, M. Aruna, S. Kinra, R. M. Sullivan, L. Bowen, N. J. Timpson, G. Davey Smith, F. Dudbridge, D. Prabhakaran, Y. Ben-Shlomo, K. S. Reddy, S. Ebrahim, G. R. Chandak. Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier. J Obes. 2011; 2011: 307542. Published online 2011 May 17. doi: 10.1155/2011/307542.
Start Year 2010
 
Description GIANT Consortium 
Organisation University of Oxford
Department Wellcome Trust Centre for Human Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided Data and Analysis from our Cohort Studies
Impact Contribution to Genome Wide Replication. Papers:- 1) Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genetics 2009;5: e1000508 2)Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics 2008; 41: 25 - 34 3)Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics 2008; 40:768-775, PMID: 18454148.
Start Year 2008
 
Description GOYA 
Organisation Danish Ministry of Health
Department Danish National Birth Cohort
Country Denmark 
Sector Public 
PI Contribution Initial formulation of the funding application for this project and then overseeing the collection and analysis of genetic data. Bristol group also largely responsible for the writing and publication of core findings.
Collaborator Contribution The initiation and undertaking of a genetic study within a sample composed of extremes of the BMI distribution. This looks at the genetics of obesity, but leaves behind a valuable genetic resource which is being used in further genetic studies.
Impact Nohr EA, Timpson NJ, Anderson CS, Davey Smith G, Olsen J, Sorensen TI. Severe Obesity in Young Women and Reproductive Health: The Danish National Birth Cohort). PLoS One 4(12) e8444. Doi:10.1371/journal.pone.0008444. Paternoster L, Evans DM, Aagaard Nohr E, Holst C, Gaborieau V, et al. 2011 Genome-Wide Population-Based Association Study of Extremely Overweight Young Adults - The GOYA Study. PLoS ONE 6(9): e24303. doi:10.1371/journal.pone.0024303
Start Year 2008
 
Description HGMD Collaboration 
Organisation Cardiff University
Department Cancer and Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution A PhD student, Hashem Shihab, who is funded from the MRC doctoral training centre, Bristol Centre for Systems Biomedicine, funded under the 2009 Maths and Stats Capacity Building call (PI Ian Day), is developing hidden Markov model based sequence alignment capitalising on the Superfamily resource run in Bristol by Julian Gough (Computer Sciences), to improve prediction of protein sequence mutations.
Collaborator Contribution HGMD is a unique database resource which we need to access for the development of a predictive software for interpreting protein sequence mutations.
Impact Draft manuscript soon to be submitted: Functional Analysis Through Hidden Markov Models: Predicting The Functional, Molecular & Phenotypic Consequences Of Amino Acid Substitutions.
Start Year 2011
 
Description Indian cohort collaborations 
Organisation Public Health Foundation of India
Department South Asia Network for Chronic Disease in India (SANCD)
Country India 
Sector Public 
PI Contribution Intellectual input to establishment of Network Training exchange Prof G Davey Smith spent sabbatical 2009-10 in India, in part working on this Network
Collaborator Contribution Grant Provision for Project undertaking
Impact Network established Sharing of data beginning
Start Year 2009
 
Description Investigation of relationship between habitual levels of physical activity 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Access to participants in order to gain new data
Impact Publications
Start Year 2006
 
Description KSU Population-based Consanguinity Research Study 
Organisation King Saud University
Department Department of Clinical Laboratory Sciences
Country Saudi Arabia 
Sector Academic/University 
PI Contribution We are guiding and leading the development of the programme (Ian Day has a programme grant full application currently under review with MRC MCMB), contribute the molecular and genetic analysis expertise and drive the writing of papers. Two co-applicants, Muslim Alsaadi, Vice Dean of Medicine, and Khalid Alharbi, represent the KSU arm of this proposal.
Collaborator Contribution Access to human genetic material (offspring of first cousin and similar marriages) not available in the UK. Since these departments are investing staff and student time into development of this research resource, there is indirect financial contribution to our research goals.
Impact First paper accepted subject to revisions: From a single whole exome read to notions of clinical screening: primary ciliary dyskinesia and RSPH9 p.Lys268del in the Arabian Peninsula. Muslim M AlSaadi, Tom R Gaunt, Christopher R Boustred, Philip AI Guthrie, Xuan Liu, Luca Lenzi, Lucille Rainbow, Neil Hall, Khalid K Alharbi and Ian NM Day
Start Year 2010
 
Description Liverpool CGR Collaboration 
Organisation University of Liverpool
Department Liverpool Centre for Genomic Research
Country United Kingdom 
Sector Academic/University 
PI Contribution We are guiding and leading the development of the programme (Ian Day has a programme grant full application currently under review with MRC MCMB), contribute the molecular and genetic analysis expertise and drive the writing of papers. A co-applicant (Neil Hall) represents Liverpool CGR.
Collaborator Contribution The CGR have run pilot whole exome sequencing as part of our development of a population-based consanguinity research study involving multiple international partners.
Impact First paper accepted subject to revisions: From a single whole exome read to notions of clinical screening: primary ciliary dyskinesia and RSPH9 p.Lys268del in the Arabian Peninsula. Muslim M AlSaadi, Tom R Gaunt, Christopher R Boustred, Philip AI Guthrie, Xuan Liu, Luca Lenzi, Lucille Rainbow, Neil Hall, Khalid K Alharbi and Ian NM Day.
Start Year 2010
 
Description MAGIC Investigators 
Organisation University of Oxford
Department Wellcome Trust Centre for Human Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided Data and Analysis from our Cohort Studies
Impact Several GWAS publications and others planned: 1. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, et al. (200+ authors). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics 2010; 42:105-116 2. Chen W-M, Erdos MR, Jackson AU, Saxena R, Sanna S, Silver KD, Timpson NJ, Hansen T, Orru M, Piras MG, Bonnycastle LL, Willer CJ, Lyssenko V, Shen H, Kuusisto J, Ebrahim S, Sestu N, Duren WL, Spada MC, Stringham HM, Scott LJ, Olla N, Swift AJ, Najjar S, Mitchell HM, Lawlor DA, Davey Smith G, Ben-Shlomo Y, Andersen G, Borch-Johnsen K, Jorgensen T, Saramies J, Valle TT, Buchanan TA, Shildiner AR, Lakatta E, Bergman RN, Uda M, Toumilehto J, Pedersen O, Cao A, Groop L, Mohlke KL, Laakso M, Schlessinger D, Collins FS, Altshuler D, Abescasis GR, Boeknke M, Scuteri A, Wantanabe RM. Variatoions in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. Journal of Clinical Investigation 2008 ;118:2620-2628 3. Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, Voss LD, Jeffrey AN, Metcalf B, Ferrucci L, Corsi AM, Murray A, Melzer D, Knight B, Shields B, Davey Smith G, Hattersley AT, Di Rienzo A, Frayling T. A common haplotype in the glucokinase gene alters fasting glucose and birth weight: association using 20,902 subjects from 6 studies and assessment of natural selection. American Journal of Human Genetics 2006;79:991-1001
Start Year 2008
 
Description Maternal overnutrition and offspring fat mass and vascular function 
Organisation University of Bristol
Department MRC Centre for Causal Analyses in Translational Epidemiology
Country United Kingdom 
Sector Public 
PI Contribution Provision of data
Impact Publications
Start Year 2006
 
Description Maternal smoking in pregnancy and child psychological problems: disentangling causal & noncausal effects 
Organisation Federal University of Pelotas (UFPel)
Department 1982 Pelotas Birth Cohort
Country Brazil 
Sector Academic/University 
PI Contribution To compare four different methods for assessing causality to explore whether maternal smoking in pregnancy is related to psychological problems.
Impact Pediatrics paper: PubMed ref: 20587678
Start Year 2008
 
Description Obesity and depression in adolescents (B659) 
Organisation University of Bristol
Department School for Policy Studies
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of data
Collaborator Contribution Provision of data
Impact publications
Start Year 2008
 
Description Pelotas 
Organisation Federal University of Pelotas (UFPel)
Department 1982 Pelotas Birth Cohort
Country Brazil 
Sector Academic/University 
PI Contribution Grants, Study Design, analysis and paper writing. Cross cohort comparisons
Collaborator Contribution Analysis and paper writing
Impact GRANS:- 1)Public health consequences of modifiable maternal exposures: offspring obesity and cognitive health in two cohorts in the UK and Brazil. Wellcome Trust (Sir Henry Wellcome Postdoctoral Fellowship). PAPERS:- 1) Maternal smoking in pregnancy and child psychological problems: disentangling causal and noncausal effects. Pediatrics 2010; doi:10.1542/peds.2009-2754. PMID: 20587678 2) Differentials and income-related inequalities in maternal depression during the first two years after childbirth: birth cohort studies from Brazil and the UK. Clinical Practice and Epidemiology in Mental Health 2009;5, 5-12, PMID:19500361. 3) Early life diarrhea and later blood pressure in a developing country: the 1982 Pelotas (Brazil) birth cohort study. Journal of Epidemiol Community Health 2009; 63:163-165, PMID:18801796. 4)Socioeconomic position and overweight among adolescents: data from birth cohort studies in Brazil and the UK. BMC Public Health 2009;9:105. PMID:19368733
Start Year 2007
 
Description Physical activity and childhood obesity 
Organisation University of Bristol
Department School for Policy Studies
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of data
Impact Publications
 
Description Raine Study 
Organisation University of Western Australia
Department Obstetrics and Gynaecology
Country Australia 
Sector Academic/University 
PI Contribution As noted above we have had an exchange of Postdoc/PhD students and via this shared knowledge and expertise and obtained grants and papers together
Collaborator Contribution Post doc fellow - Marie-Jo Brion from MRC CAiTE has been working at UWA helping them to establish expertise in Mendelian Randomization studies Two of their PhD students have spent time at MRC CAiTE learning more about statistical analyses for causal mechanisms
Impact GRANTS:- 1)Palmer L(PI), Pennell C, Beilin L, Lye S, Newnham J. Davey Smith G. A genome-wide search for genes underlying the developmental origins of health and disease. 1st January 2009 for 3 years.  National Health and Medical Research Council (572613), Aus$989,500: 2009-2011. 2. Adams L (PI), Olynyh J, Beilin L, Pennell C, Oddy W, Mccaskie P, Lawlor DA. Risk factors for the development of NAFLD beyond insulin resistance: genetic, development and environmental influences (66445). Australian National Health and Medical Research Council Aus $641,125: 2010-2013 PAPERS:- 1)The association of C-reactive protein and CRP genotype with coronary heart disease: Findings from five studies with 4,610 cases amongst 18,637 participants. PloS One 2008; 3:e3011, PMID: 18714384. A number of others currently being drafted
Start Year 2007
 
Description Ten Towns Heart Health Study 
Organisation St George's University of London
Department Division of Population Health Sciences and Education
Country United Kingdom 
Sector Academic/University 
PI Contribution We designed the study, were involved in the genotypic analyses, contributed to the statistical analyses and drafted the manuscript.
Collaborator Contribution They have contributed DNA from Ten Towns Heart Health Study participants for SNP genotyping. They also contributed relevant phenotypes such as cotinine and also a large number of smoking phenotypes from questionnaires. They conducted statistical tests and contributed to drafting a paper.
Impact Santiago Rodriguez, Derek G. Cook, Tom R. Gaunt, Claire M. Nightingale, Peter H. Whincup, Ian N. M. Day. 2011. Combined analysis of CHRNA5, CHRNA3 and CYP2A6 in relation to adolescent smoking behaviour. Journal of Psychopharmachology 25(7):915-923. Santiago Rodriguez. 2010. Smoking behaviour: contrasts and combinations of CHRNA5 and CYP2A6 genotype. Collaboration Development Workshop. Beijing, 29-30 March 2010. Oral presentation.
Start Year 2006
 
Description The Hertfordshire Cohort Study 
Organisation University of Southampton
Department MRC Lifecourse Epidemiology Unit
Country United Kingdom 
Sector Public 
PI Contribution We participated in the study designs, contributed genotyping data, helped with the statistical analyses and were involved in manuscript writing.
Collaborator Contribution They made available to us DNA from the Hertfordshire participants for SNP genotyping; also a large number of phenotypes including bone and anthropometric phenotypes, as well as blood biomarkers.
Impact Mirjam A Lips, Holly E Syddall, Tom R Gaunt, Santiago Rodriguez, Ian NM Day, Cyrus Cooper, Elaine M Dennison and the Southampton Genetic Epidemiology Research Group. 2007. Interaction between birth-weight and polymorphism in the Calcium Sensing Receptor gene in determination of adult bone mass: The Hertfordshire Cohort Study. Journal of Rheumatology 34: 769-775. Elaine M. Dennison, Holly E. Syddall, Karen A. Jameson, Avan Aihie Sayer, Tom R. Gaunt, Santiago Rodriguez, Ian N.M. Day, Cyrus Cooper and Mirjam A. Lips, the Hertfordshire Cohort Study Group. 2009. A study of relationships between Single Nucleotide Polymorphisms from the Growth Hormone- Insulin Like Growth Factor axis and bone mass: the Hertfordshire Cohort Study. Journal of Rheumatology 36(7):1520-1526. Lips MA, Syddall HE, Day INM, Gaunt TR, Rodriguez S, Cooper C, Dennison EM. 2006. Evidence for an early life Calcium sensing receptor gene polymorphism interaction in determination of adult bone mass: The Hertfordshire cohort study. Abstract published in Osteoporosis International 17 Suppl. 2: S345. EM Dennison, HE Syddall, INM Day, TR Gaunt, S Rodriguez, M Lips, C Cooper. 2006. Early life-calcium sensing receptor gene polymorphism interaction in determination of adult bone mass: The Hertfordshire Cohort Study. Abstract published in the Journal of Bone and Mineral Research 21: 1156.
Start Year 2006
 
Description The functional study of preterm birth 
Organisation Peninsula College of Medicine & Dentistry
Country United Kingdom 
Sector Academic/University 
PI Contribution ALSPAC provided biological samples, in order for new data to be generated.
Impact Publications
Start Year 2008
 
Description The longitudinal courses of depressive symptoms from late childhood to early adolescence and the association with socio-demographic and family factors 
Organisation University of Bristol
Department School of Social and Community Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of data
Impact Publications
Start Year 2007
 
Description The origins and outcomes of persisting phonological impairment. 
Organisation University of the West of England
Department Department of Health and Social Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of data
Impact Publications
 
Description The prevalence of dizziness and balance problems in childhood 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of data
Impact Publications
Start Year 2007
 
Description The role of familial adiposity in explaining associations of hypertensive disorder of pregnancy with offspring blood pressure. 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Aim is to examine the association of gestational hypertension and pre-eclampsia with offspring blood pressure and to explore the extent to which any associations are explained by familial adiposity.
Impact ALSPAC paper under review; Generation R paper drafted
Start Year 2008
 
Description The role of genotype and maternal smoking during pregnancy on offspring smoking initiation 
Organisation University of Bristol
Department School of Experimental Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of existing data, Access to participants for new questionnaires to be sent and new samples taken
Impact Publications
Start Year 2007
 
Description To assess whether age at onset of puberty is influenced by intrauterine exposure to endocrine disrupting chemicals. 
Organisation Centers for Disease Control and Prevention (CDC)
Country United States 
Sector Public 
PI Contribution Access to study participants via questionnaire
Impact Publications
 
Description UCL-Bristol-Leicester-QMUL CardioChip consortium 
Organisation Queen Mary University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data sharing within consortium.
Collaborator Contribution Data sharing within the consortium.Data sharing within consortium.Data sharing within consortium.
Impact Disciplines: Statistical genetics, Genetic epidemiology, Molecular Genetics, Bioinformatics. Shah S*, Nelson CP*, Gaunt TR* [* equal authorship], van der Harst P, Barnes T, Braund PS, Lawlor DA, Casas JP, Padmanabhan S, Drenos F, Kivimaki M, Talmud PJ, Humphries SE, Whittaker J, Morris RW, Whincup PH, Dominiczak A, Munroe PB, Johnson T, Goodall AH, Cambien F, Diemert P, Hengstenberg C, Ouwehand WH, Felix JF, Glazer NL, Tomaszewski M, Burton PR, Tobin MD, van Veldhuisen DJ, de Boer RA, Navis G, van Gilst WH, Mayosi BM, Thompson JR, Kumari M, Macfarlane PW, Day IN*, Hingorani AD*, Samani NJ*. Four Genetic Loci Influencing Electrocardiographic Indices of Left Ventricular Hypertrophy. Circ Cardiovasc Genet. 2011 Sep 30; [Epub ahead of print] International Consortium for Blood Pressure Genome-Wide Association Studies; [Author 61/839: Gaunt TR] Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-9. Zabaneh D*, Gaunt TR* [*equal authors], Kumari M, Drenos F, Shah S, Berry D, Power C, Hypponen E, Shah T, Palmen J, Pallas J, Talmud PJ, Casas JP, Sofat R, Lowe G, Rumley A, Morris RW, Whincup PH, Rodriguez S, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Kivimaki M, Whittaker J, Hingorani AD, Day IN*, Humphries SE*. Genetic Variants Associated with von Willebrand Factor Levels in Healthy Men and Women Identified Using the HumanCVD BeadChip. Ann Hum Genet. 2011 Apr 28; [Epub ahead of print] Talmud PJ, Cooper JA, Gaunt T, Holmes MV, Shah S, Palmen J, Drenos F, Shah T, Kumari M, Kivimaki M, Whittaker J, Lawlor DA, Day IN, Hingorani AD, Casas JP, Humphries SE. Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies. Diabetologia. 2011 Apr 1; [Epub ahead of print] Smart-Halajko MC, Robciuc MR, Cooper JA, Jauhiainen M, Kumari M, Kivimaki M, Khaw KT, Boekholdt SM, Wareham NJ, Gaunt TR, Day IN, Braund PS, Nelson CP, Hall AS, Samani NJ, Humphries SE, Ehnholm C, Talmud PJ. The Relationship Between Plasma Angiopoietinlike Protein 4 Levels, Angiopoietinlike Protein 4 Genotype, and Coronary Heart Disease Risk. Arterioscler Thromb Vasc Biol. 2010 Sep 9; [Epub ahead of print] Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD; ASCOT investigators; NORDIL investigators; BRIGHT Consortium. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet. 2009 Nov;85(5):628-42. ]
Start Year 2009
 
Description UCL-Bristol-Leicester-QMUL CardioChip consortium 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data sharing within consortium.
Collaborator Contribution Data sharing within the consortium.Data sharing within consortium.Data sharing within consortium.
Impact Disciplines: Statistical genetics, Genetic epidemiology, Molecular Genetics, Bioinformatics. Shah S*, Nelson CP*, Gaunt TR* [* equal authorship], van der Harst P, Barnes T, Braund PS, Lawlor DA, Casas JP, Padmanabhan S, Drenos F, Kivimaki M, Talmud PJ, Humphries SE, Whittaker J, Morris RW, Whincup PH, Dominiczak A, Munroe PB, Johnson T, Goodall AH, Cambien F, Diemert P, Hengstenberg C, Ouwehand WH, Felix JF, Glazer NL, Tomaszewski M, Burton PR, Tobin MD, van Veldhuisen DJ, de Boer RA, Navis G, van Gilst WH, Mayosi BM, Thompson JR, Kumari M, Macfarlane PW, Day IN*, Hingorani AD*, Samani NJ*. Four Genetic Loci Influencing Electrocardiographic Indices of Left Ventricular Hypertrophy. Circ Cardiovasc Genet. 2011 Sep 30; [Epub ahead of print] International Consortium for Blood Pressure Genome-Wide Association Studies; [Author 61/839: Gaunt TR] Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-9. Zabaneh D*, Gaunt TR* [*equal authors], Kumari M, Drenos F, Shah S, Berry D, Power C, Hypponen E, Shah T, Palmen J, Pallas J, Talmud PJ, Casas JP, Sofat R, Lowe G, Rumley A, Morris RW, Whincup PH, Rodriguez S, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Kivimaki M, Whittaker J, Hingorani AD, Day IN*, Humphries SE*. Genetic Variants Associated with von Willebrand Factor Levels in Healthy Men and Women Identified Using the HumanCVD BeadChip. Ann Hum Genet. 2011 Apr 28; [Epub ahead of print] Talmud PJ, Cooper JA, Gaunt T, Holmes MV, Shah S, Palmen J, Drenos F, Shah T, Kumari M, Kivimaki M, Whittaker J, Lawlor DA, Day IN, Hingorani AD, Casas JP, Humphries SE. Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies. Diabetologia. 2011 Apr 1; [Epub ahead of print] Smart-Halajko MC, Robciuc MR, Cooper JA, Jauhiainen M, Kumari M, Kivimaki M, Khaw KT, Boekholdt SM, Wareham NJ, Gaunt TR, Day IN, Braund PS, Nelson CP, Hall AS, Samani NJ, Humphries SE, Ehnholm C, Talmud PJ. The Relationship Between Plasma Angiopoietinlike Protein 4 Levels, Angiopoietinlike Protein 4 Genotype, and Coronary Heart Disease Risk. Arterioscler Thromb Vasc Biol. 2010 Sep 9; [Epub ahead of print] Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD; ASCOT investigators; NORDIL investigators; BRIGHT Consortium. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet. 2009 Nov;85(5):628-42. ]
Start Year 2009
 
Description UCL-Bristol-Leicester-QMUL CardioChip consortium 
Organisation University of Leicester
Country United Kingdom 
Sector Academic/University 
PI Contribution Data sharing within consortium.
Collaborator Contribution Data sharing within the consortium.Data sharing within consortium.Data sharing within consortium.
Impact Disciplines: Statistical genetics, Genetic epidemiology, Molecular Genetics, Bioinformatics. Shah S*, Nelson CP*, Gaunt TR* [* equal authorship], van der Harst P, Barnes T, Braund PS, Lawlor DA, Casas JP, Padmanabhan S, Drenos F, Kivimaki M, Talmud PJ, Humphries SE, Whittaker J, Morris RW, Whincup PH, Dominiczak A, Munroe PB, Johnson T, Goodall AH, Cambien F, Diemert P, Hengstenberg C, Ouwehand WH, Felix JF, Glazer NL, Tomaszewski M, Burton PR, Tobin MD, van Veldhuisen DJ, de Boer RA, Navis G, van Gilst WH, Mayosi BM, Thompson JR, Kumari M, Macfarlane PW, Day IN*, Hingorani AD*, Samani NJ*. Four Genetic Loci Influencing Electrocardiographic Indices of Left Ventricular Hypertrophy. Circ Cardiovasc Genet. 2011 Sep 30; [Epub ahead of print] International Consortium for Blood Pressure Genome-Wide Association Studies; [Author 61/839: Gaunt TR] Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-9. Zabaneh D*, Gaunt TR* [*equal authors], Kumari M, Drenos F, Shah S, Berry D, Power C, Hypponen E, Shah T, Palmen J, Pallas J, Talmud PJ, Casas JP, Sofat R, Lowe G, Rumley A, Morris RW, Whincup PH, Rodriguez S, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Kivimaki M, Whittaker J, Hingorani AD, Day IN*, Humphries SE*. Genetic Variants Associated with von Willebrand Factor Levels in Healthy Men and Women Identified Using the HumanCVD BeadChip. Ann Hum Genet. 2011 Apr 28; [Epub ahead of print] Talmud PJ, Cooper JA, Gaunt T, Holmes MV, Shah S, Palmen J, Drenos F, Shah T, Kumari M, Kivimaki M, Whittaker J, Lawlor DA, Day IN, Hingorani AD, Casas JP, Humphries SE. Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies. Diabetologia. 2011 Apr 1; [Epub ahead of print] Smart-Halajko MC, Robciuc MR, Cooper JA, Jauhiainen M, Kumari M, Kivimaki M, Khaw KT, Boekholdt SM, Wareham NJ, Gaunt TR, Day IN, Braund PS, Nelson CP, Hall AS, Samani NJ, Humphries SE, Ehnholm C, Talmud PJ. The Relationship Between Plasma Angiopoietinlike Protein 4 Levels, Angiopoietinlike Protein 4 Genotype, and Coronary Heart Disease Risk. Arterioscler Thromb Vasc Biol. 2010 Sep 9; [Epub ahead of print] Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD; ASCOT investigators; NORDIL investigators; BRIGHT Consortium. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet. 2009 Nov;85(5):628-42. ]
Start Year 2009
 
Description UCLEB 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data sharing within consortium.
Collaborator Contribution Data sharing within consortium.Data sharing within consortium.
Impact Disciplines: Statistical genetics, Genetic epidemiology, Molecular Genetics, Bioinformatics. BHF programme grant funding (PI Aroon Hingorani, UCL)
Start Year 2011
 
Description UCLEB 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Data sharing within consortium.
Collaborator Contribution Data sharing within consortium.Data sharing within consortium.
Impact Disciplines: Statistical genetics, Genetic epidemiology, Molecular Genetics, Bioinformatics. BHF programme grant funding (PI Aroon Hingorani, UCL)
Start Year 2011
 
Description UK10K 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Co-applicants on successful grant application to Wellcome Trust. Will work with Sanger and other cohorts to establish sequence data (including in ALSPAC) and undertake appropriate analyses with these.
Collaborator Contribution Grant Provision for Project undertaking
Impact Successful grant Data collection will start in 2011 for this collaboration
Start Year 2010
 
Description Wellcome Trust Case Control Consortium 
Organisation Peninsula College of Medicine & Dentistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided and Analysis from our cohort studies
Impact Contribution to Genome Wide Replication, Papers:- Genome-wide association analysis identifies 20 loci that influence adult height.Nat Genet. 2008 May;40(5):575-83. Epub 2008 Apr 6 Comment in:- Nat Genet. 2008 May;40(5):489-90. PMID: 18391952 , A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894, PMID:17434869, A common variant of HMGA2 is associated with adult and childhood height in the general population. Nature genetics 2007; 39:1245-1250, PMID: 17767157, Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected, given its effect on BMI. Diabetes 2008;57: 1419-1426, PMID: 18346983, A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. Human Molecular Genetics 2009;18:2922-2927. PMID:19429911, Type 2 Diabetes Risk Alleles are Associated with Reduced Size at Birth. Diabetes 2009; 58:1428-1433, PMID: 19228808, Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight, Nature Genetics 2010,42:430-435. PMID:20372150,
Start Year 2008
 
Description pQCT 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis of genome-wide association data.
Collaborator Contribution Provision of genome-wide association summary statistics for meta-analysis.
Impact PMID: 21124946 ; PMID: 20534768
Start Year 2010
 
Description A seminar by a member of Science Media Centre was organised 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Dr Nicolas Timpson organised a seminar for the department by Dr Helen Jamieson of Science Media Centre whose talk was "Science and the Media: Experience from the front line"

This generated interest to members of the department, and other parts of the faculty about scientists engaging with the public.
Year(s) Of Engagement Activity 2009
 
Description 8th Mackenzie Lecture University of Dundee 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact Invited Speaker - "The Limits of Personalised Medicine: Epidemiological Reflections"

Increased interest in Mendelian Randomization
Year(s) Of Engagement Activity 2013
 
Description Article for Department of Education 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Suzi Gage, the PhD student who wrote the article, was invited to give a seminar on her paper at the Department for Education. This was broadcast across four of their sites.

None so far.
Year(s) Of Engagement Activity 2010
 
Description Article for FutureMorph website 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact FutureMorph is a website for teenagers about the exciting possibilities of studying STEM subjects. The article will have helped generate conversation and debate on this subject.

None so far.
Year(s) Of Engagement Activity 2011
 
Description BBC Radio 4 interview for the programme, 'Sick Society' , as part of the 'Analysis' series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The interview was broadcast as part of an established series on Radio 4 and would have reached a large national audience.

The programme is likely to have provoked thought and stimulated discussion amongst the listeners and to have given rise to feedback.
Year(s) Of Engagement Activity 2012
 
Description CIHR STAGE 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact CIHR STAGE International Speaker Seminar Series. The Hospital for Sick Children, Toronto Canada, 3rd May 2013 - "How Can Genetic Epidemiology Help Identify Causes of Disease?"

Informed discussion
Year(s) Of Engagement Activity 2013
 
Description Conference on diet and coronary heart disease Oslo 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact Conference on diet and coronary heart disease. Hotel Bristol, Oslo, Norway 24-25 January 2013 - 'Causation and causal inference in epidemiology'

Raised discussion on the relationship between epidemiology, diet and coronary heart disease
Year(s) Of Engagement Activity 2013
 
Description Consultant to the Science Musem - update on Epidemiology section of the Health Matters modern medicine gallery 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Professor George Davey Smith to be Consultant to the Science Museum for described activity.

Unknown
Year(s) Of Engagement Activity 2008
 
Description Doc/Fest film festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The member of staff was able to discuss science with members of the public.

A number of people who do not necessarily think about science will have been reached though their attendance at this Festival.
Year(s) Of Engagement Activity 2012
 
Description Helped at MRC stand at the Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Dr Philip Guthrie and Ms Marie Elmhirst helped at the MRC stand in the Discover Zone over 5 days at the Cheltenham Science Festival in 2008.

Unknown
Year(s) Of Engagement Activity 2008
 
Description Helping with MRC stall at one day Oxford Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Many older and primary-school age children and their parents spent time at the stall; the children were able to paint pictures of cells, model different types of cell in clay and have a model of the human body dismantled and explained to them; their parents were able to ask questions about science and the work of the MRC.

Students of GCSE age asked specific questions with a view to choosing science subjects to study at university.
Year(s) Of Engagement Activity 2010
 
Description I'm a Scientist, Get Me Out of Here 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Schools
Results and Impact Suzi Gage, a PhD student, won the Brain Zone; her prize was £500 to spend on science communication.

She received some extra funding from the MRC and is using that and her prize money to make a series of podcasts aimed at teenagers, explaining current evidence on the effects of taking recreational drugs.
Year(s) Of Engagement Activity 2011
 
Description Ian Day gave a lecture to Bristol Enterprise Network 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentation titled, "The potential of genetics to enable personalization of healthcare" for an evening themed, "The Personalised Health Care Revolution".

Unknown
Year(s) Of Engagement Activity 2009
 
Description Integrative Comments 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact University of Sao Paulo Conference, Sao Paulo Brazil, 14-15 March 2013

Informed debate
Year(s) Of Engagement Activity 2013
 
Description Interview as part of an article for 'New Scientist' magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Too early to say, but likely to be discussed on 'New Scientist' letters page and website.

Too early to say, but likely to be feedback through 'New Scientist' letters page and website.
Year(s) Of Engagement Activity 2012
 
Description Interview for BBC Radio 4's programme, 'Science: From Cradle to Grave' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Professor George Davey Smith was able to widen listeners' understanding of longitudinal studies.

None so far.
Year(s) Of Engagement Activity 2011
 
Description Interview for BBC Radio Bristol on ageing and genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Professor Ian Day was interviewed by Dr Phil Hammond on Saturday Surgery and was able to further the local public's understanding of this area of science.

None so far.
Year(s) Of Engagement Activity 2011
 
Description Interview inputs about human genetics to a film documentary 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Film being made by Dan Lewis (3rd year UWE Media and Cultural Studies on the subject of 'Science Ideology and Society'

Unknown
Year(s) Of Engagement Activity 2009
 
Description Lecture to 6th form pupils at Redland School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact The lecture generated discussion and further debate.

Invitations for further involvement with the school.
Year(s) Of Engagement Activity 2010
 
Description MRC CAiTE staff and PhD Students Volunteered on the MRC Stand at the Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Schools
Results and Impact Ms Bhavna Mistry, Ms Anya Burton, Mr Chris Boustred, Mr Dylan Williams volunteered at the MRC Stand on various days throughout the Cheltenham Science Festival June 2010

Unknown
Year(s) Of Engagement Activity 2010
 
Description MRC CAiTE staff and PhD Students Volunteered on the MRC Stand at the Oxfordshire Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Schools
Results and Impact Dr Philip Guthrie and Mr Dylan Williams (PhD student) volunteered on the MRC Stand at the Oxfordshire Science Festival

Unknown
Year(s) Of Engagement Activity 2010
 
Description MRC Population Cohort Strategy Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Health professionals
Results and Impact Portfolio Balance. MRC Population Cohort Strategy Workshop 6th March 2013

Informed discussion
Year(s) Of Engagement Activity 2013
 
Description MRC centenary showcase at M Shed Bristol 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Professor Debbie Lawlor gave a presentation to the entire audience (200) about ALSPAC, and two study participants led two round table sessions (each with 10-12 people) about their role in ALSPAC's teenage advisory panel.

Event generated lots of stimulating discussion and debate.
Year(s) Of Engagement Activity 2013
URL http://www.bristol.ac.uk/news/2013/9471.html and http://www.centenary.mrc.ac.uk/open_days/mrcunivers...
 
Description MRC stall, Cheltenham Science Festival, manned by Chris Boustred and Dylan Williams, PhD students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Schoolchildren of various ages and members of the general public learned about neuroscience through displays, demonstrations and hands-on activities.

Students of GCSE age asked specific questions with a view to choosing science subjects to study at university.
Year(s) Of Engagement Activity 2010
 
Description Manning MRC stand at Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The stand and Festival attracted a large audience from across the region.

School-age children attending with their parents will have been stimulated to study science subjects at school and beyond.
Year(s) Of Engagement Activity 2012
 
Description Media coverage of research paper in Circulation, an American journal 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A press release was sent to specific contacts in the national press, including the science reporter on the Daily Mail; the latter printed a piece about the research on June 2nd. Abigail Fraser, the co-author of the paper, participated in a local radio programme in Bristol.

Unknown
Year(s) Of Engagement Activity 2010
 
Description OMICS 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact OMICS Omics Conference,Bristol 19th June 2013

Discussion of the relationship between omics and nutrition
Year(s) Of Engagement Activity 2013
 
Description PHD student became science correspondent for the University of Bristol's newspaper 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Current questions in science research are being brought to the attention of all staff and students at the University of Bristol by Suzi Gage's articles.

None so far.
Year(s) Of Engagement Activity 2011
 
Description PHRI Rounds Hamilton Canada 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact PHRI Rounds. Population Health Research Institute, Hamilton, Canada - 7th May 2013. "Mendelian randomization in cardiovascular disease: what does the future hold?"

Informed discussion
Year(s) Of Engagement Activity 2013
 
Description Participation in a Science Cafe at the Tobacco Factory in Bristol 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Dr Laura Howe was able to discuss careers in science research with the attendees and to explain her research using the ALSPAC data.

None so far.
Year(s) Of Engagement Activity 2011
 
Description Population Sciences Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact Population Sciences Lecture - Population Health Research Institute, Hamilton, Canada, 7 May 2013. "The limits of personalized medicine: epidemiological reflections"

Informed discussion
Year(s) Of Engagement Activity 2013
 
Description Presentations at the Public Health Grand Round 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Oral Presentations by Professor Debbie Lawlor and Dr Nicolas Timpson

Unknown
Year(s) Of Engagement Activity 2008
 
Description Public Debate on the Future of Genomics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Professor George Davey Smith took part in this public discussion event held at 'Explore @ Bristol' The exhibition called "Inside DNA: A Genomic Revolution" is the UK's first major touring exhibition on genomics.

Unknown
Year(s) Of Engagement Activity 2007
 
Description Queensland Institute of Medical Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact External Seminar Series, Queensland Institute of Medical Research, Australia - 9th April 2013 - Mendelian Randomization: the next ten years

Informed discussion
Year(s) Of Engagement Activity 2013
 
Description SPark in the Science City Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Ms Marie Elmhirst attended the SPark in the Science City conference on 29th April 2008. SPark is the new £300 million science park for Bristol and Bath.

Unknown
Year(s) Of Engagement Activity 2008
 
Description School student was hosted at MRC CAiTE over a summer holiday period 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Professor Ian Day hosted a school student from Wessex Setpoint during summer 2008, and attended and made input to the Wessex Setpoint presentation day event in Bath in September 2008. The student learned about genocopy/phenocopy effects and applied this to analysis of pigmentation effects in age-related macular degeneration and to effects of smoking or nicotine across a wide range of diseases. This was under a Nuffield Bursary.

In March 2009 the student was to present at the national UK Young scientists' and Engineers' Fair 2009. This Centre to a bright and ambitious national cadre of school students.
Year(s) Of Engagement Activity 2008
 
Description Science Alive 2008! 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Schools
Results and Impact Demonstrations and activities/poster displays about the University's research held in the public shopping area of Broadmead in Bristol. This is to allow school children and shoppers to explore the various activities.

Unknown
Year(s) Of Engagement Activity 2008
 
Description TEDx Bristol 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact TEDx are making a film about Dr Rebecca Peason's work on depressogenic cognitive style in the cohort which will be shown at TEDx as part of the 'Psychology of Failure' theme in which George Davey Smith is a key participant. The resulting film will be available on the TEDx website and ALSPAC's YouTube channel.

The event is taking place on 11 November so too earlier to report on impact.
Year(s) Of Engagement Activity 2013
URL http://tedxbristol.com/
 
Description Talk at Summer School for years 11 to 12 students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Schools
Results and Impact Professor Debbie Lawlor gave a talk entitled "Detective Work in Medical Research".

Unknown
Year(s) Of Engagement Activity 2008
 
Description Techniquest lecture, Cardiff 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The lecture contributed to a public discussion about whether weight is destined by genes.

Will have led to further debate.
Year(s) Of Engagement Activity 2011
 
Description The Huxley Debate 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Health professionals
Results and Impact Participant in the Huxley Debate on The Science of Epigenetics

Enlightening the audience in the science of epigenetics
Year(s) Of Engagement Activity 2013
 
Description The Legacy of John Snow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact University of Sao Paulo Conference, Brazil - Cholera Vaccination 1894: the first controlled medical trial. The legacy of John Snow: epidemiology yesterday, today and tomorrow

Informed discussion
Year(s) Of Engagement Activity 2013
 
Description Twilight talk 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 160 members of the public attended. The evening was a series of round table talks with members of the public selecting 3 of these from 'lay abstracts' that were submitted by the academics. After 40 minutes a bell sounded and the member of the public moved on to their next discussion topic. The academic was there to answer questions and facilitate discussion in a pre-specified area. Prof DA Lawlor supported a table discussion on the role of reproductive health in healthy ageing.

Feedback was excellent with 90% reporting that they had enjoyed and learnt from the evening and 85% saying that they would definitely attend another similar event.
Year(s) Of Engagement Activity 2006,2010
 
Description Two Page Spread in Bristol Evening Post 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact A two page spread in the Bristol Evening Post of 4th June 2008 on the work of Professor Debbie Lawlor on the two year study to understand the causes, development and prevention of obesity, diabetes and heart disease in women.

Unknown
Year(s) Of Engagement Activity 2008