Centre for molecular-based causal analyses in health and disease
Lead Research Organisation:
University of Bristol
Department Name: Social Medicine
Abstract
Please see case for support, as advised by MRC head office
Technical Summary
The proposed MRC Centre for Molecular-based Causal Analyses in Health and Disease will integrate
evidence from cellular, animal, bio-informatic and large population based studies to determine
causal pathways of relevance to the aetiology, diagnosis, prognosis, progression and
treatment of disease. The anticipated output of the Centre will be knowledge that informs the
development and implementation of clinical and population based strategies to reduce morbidity and
mortality. Specification of causal associations between modifiable risk factors and disease will
determine the optimal interventions for preventing disease. Similarly, identifying causal associations
between modifiable risk factors and disease progression in patients will allow for estimation of
prognosis and determination of the most effective interventions for secondary prevention and
reversal of disease processes. Since biomarkers on causal pathways between disease initiation and
clinical presentation will provide useful diagnostic tools, the work of the Centre will also inform
means of diagnosing common pathologies at an early stage.
Our mission will be achieved through the translational integration of inter-disciplinary research
findings from cellular studies, animal models, bioinformatic investigations, data-mining approaches,
microarray expression data, and genotype and phenotype data from large-scale population-based
cohort studies, case-control studies and clinical cohorts. The elaboration and application of
appropriate data analysis methods that draw strength from all levels of evidence will complement
the collection and compilation of empirical data and will maximise the practical utility of research
findings.
evidence from cellular, animal, bio-informatic and large population based studies to determine
causal pathways of relevance to the aetiology, diagnosis, prognosis, progression and
treatment of disease. The anticipated output of the Centre will be knowledge that informs the
development and implementation of clinical and population based strategies to reduce morbidity and
mortality. Specification of causal associations between modifiable risk factors and disease will
determine the optimal interventions for preventing disease. Similarly, identifying causal associations
between modifiable risk factors and disease progression in patients will allow for estimation of
prognosis and determination of the most effective interventions for secondary prevention and
reversal of disease processes. Since biomarkers on causal pathways between disease initiation and
clinical presentation will provide useful diagnostic tools, the work of the Centre will also inform
means of diagnosing common pathologies at an early stage.
Our mission will be achieved through the translational integration of inter-disciplinary research
findings from cellular studies, animal models, bioinformatic investigations, data-mining approaches,
microarray expression data, and genotype and phenotype data from large-scale population-based
cohort studies, case-control studies and clinical cohorts. The elaboration and application of
appropriate data analysis methods that draw strength from all levels of evidence will complement
the collection and compilation of empirical data and will maximise the practical utility of research
findings.
Organisations
- University of Bristol, United Kingdom (Collaboration, Lead Research Organisation)
- University of Southampton, United Kingdom (Collaboration)
- Norwegian National Birth Cohort (Collaboration)
- University College London, United Kingdom (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- The International Centre for Life (Collaboration)
- Public Health Foundation of India (Collaboration)
- University of Amsterdam (Collaboration)
- Icelandic Heart Association (IHA) (Collaboration)
- Harvard University (Collaboration)
- Federal University of Pelotas (Collaboration)
- Queen Mary, University of London, United Kingdom (Collaboration)
- University of Liverpool, United Kingdom (Collaboration)
- Cardiff University, United Kingdom (Collaboration)
- National Heart, Lung, and Blood Institute (NHLBI) (Collaboration)
- University of Queensland, Australia (Collaboration)
- European Commission, Belgium (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- King Saud University (Collaboration)
- Centers for Disease Control and Prevention (CDC) (Collaboration)
- CHICOS: Developing a Child Cohort Research Strategy for Europe (Collaboration)
- St George's University of London, United Kingdom (Collaboration)
- Center for Research in Environmental Epidemiology (Collaboration)
- The Wellcome Trust Sanger Institute (Collaboration)
- Erasmus University Rotterdam (EUR) (Collaboration)
- University of the West of England, United Kingdom (Collaboration)
- University of Cambridge, United Kingdom (Collaboration)
- University of Exeter, United Kingdom (Collaboration)
- McGill University, Canada (Collaboration)
- Danish Ministry of Health (Collaboration)
- University of Aberdeen, United Kingdom (Collaboration)
- Bradford Institute for Health Research (Collaboration)
- Copenhagen University Hospital (Collaboration)
- Peninsula College Of Medecine and Dentistry Foundation, Plymouth (Collaboration)
- University of Western Australia, Australia (Collaboration)
- King's College London, United Kingdom (Collaboration)
- University of Leicester, United Kingdom (Collaboration)
Publications
Howe LD
(2009)
Accuracy of height and weight data from child health records.
in Archives of disease in childhood
Kipping RR
(2008)
Randomised controlled trial adapting US school obesity prevention to England.
in Archives of disease in childhood
Fraser A
(2007)
Gamma-glutamyltransferase is associated with incident vascular events independently of alcohol intake: analysis of the British Women's Heart and Health Study and Meta-Analysis.
in Arteriosclerosis, thrombosis, and vascular biology
Smart-Halajko MC
(2010)
The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk.
in Arteriosclerosis, thrombosis, and vascular biology
Joshi R
(2012)
Is there a higher genetic load of susceptibility loci in familial ankylosing spondylitis?
in Arthritis care & research
Jefferis BJ
(2010)
Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women.
in Atherosclerosis
Ferrie JE
(2013)
Job insecurity and incident coronary heart disease: the Whitehall II prospective cohort study.
in Atherosclerosis
| Description | (MJ Brion, Fellow) Public health consequences of modifiable maternal exposures: offspring obesity and cognitive health in two cohorts in the UK and Brazil |
| Amount | £250,000 (GBP) |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | A Fraser(post doctoral fellow) Obstetric, lifestyle and genetic determinants of vascular and metabolic traits in women in early middle-age. MRC health services and health of the public research fellowship |
| Amount | £336,579 (GBP) |
| Funding ID | G0701594 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | A cluster randomised controlled trial of a primary school-based intervention to increase levels of physical activity, decrease sedentary behaviour and improve diet |
| Amount | £1,464,457 (GBP) |
| Funding ID | 09/3005/04 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | A genome based recall pilot study to compare use of liver enzymes, ultrasound scan and magnetic resonance imaging for identifying non-alcoholic fatty liver disease in epidemiological studies. |
| Amount | £58,413 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | A graphical model approach to pedigree construction using constrained optimisation |
| Amount | £446,718 (GBP) |
| Funding ID | G1002312 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | A systems approach to the classification of genes impacting the cardiovascular phenome |
| Amount | £310,320 (GBP) |
| Funding ID | G1000427 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | A systems approach to the classification of genes impacting the cardiovascular phenome |
| Amount | £310,320 (GBP) |
| Funding ID | G1000427 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Accessible Resource for Integrated Epigenomics Studies |
| Amount | £1,480,134 (GBP) |
| Funding ID | BB/I025751/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | An examination of the association of maternal vitamin D status with abnormal glucose tolerance in pregnancy |
| Amount | £51,473 (GBP) |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | An examination of the association of maternal vitamin D status with abnormal glucose tolerance in pregnancy. |
| Amount | £51,473 (GBP) |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Behavioural and neurophysiological effects of schizophrenia risk genes |
| Amount | £789,477 (GBP) |
| Funding ID | MR/K004360/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Body weight and shape as determinants of risk of NAFLD in adults |
| Amount | £349,873 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Breastfeeding RCT: Adolescent Neurocognitive Respiratory Function |
| Amount | £1,141,755 (GBP) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | |
| Description | Bristol NIHR Biomedical Research Centre |
| Amount | £20,858,545 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 03/2022 |
| Description | British Heart Foundation Project Grant |
| Amount | £130,493 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | British Heart Foundation Project grant |
| Amount | £237,731 (GBP) |
| Funding ID | Not known |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2011 |
| End | 03/2014 |
| Description | British Women's Heart & Health Study: causes and consequences of cardiovascular disease. |
| Amount | £308,528 (GBP) |
| Funding ID | PG/09/022/26739 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | British Women's Heart & Health Study: the causes and consequences of cardiovascular disease in women |
| Amount | £538,932 (GBP) |
| Organisation | Department for Business, Energy & Industrial Strategy |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | C Gregson (Fellowship) Investigation of the epidemiology and heritability of high bone mass. |
| Amount | £405,008 (GBP) |
| Organisation | Wings for Life Spinal Cord Research Foundation |
| Sector | Private |
| Country | Austria |
| Start | |
| Description | CHICOS Developing a Child Cohort Research Strategy for Europe (1.5m euros across 9 participants) |
| Amount | £135,767 (GBP) |
| Funding ID | 241604 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Characterisation of osteoarthritis phenoptype in a unique multi-centre cohort of individuals with extremely high bone mass |
| Amount | £164,748 (GBP) |
| Funding ID | 19580 |
| Organisation | Versus Arthritis |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Colston Research Society Symposium: The New Genomics: Public Health, Social and Clinical Implications |
| Amount | £5,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Department of Biotechnology, India (Genetic Association Study COPD genetics consortium) |
| Amount | £326,737 (GBP) |
| Organisation | Ministry of Science and Technology India |
| Sector | Public |
| Country | India |
| Start | |
| Description | Determining novel causal risk factors for CVD from early life to adulthood: An original genome-wide Mendelian Randomization approach |
| Amount | € 350,000 (EUR) |
| Organisation | Transatlantic Networks of Excellence in Cardiovascular Research Program |
| Sector | Charity/Non Profit |
| Country | France |
| Start | |
| Description | Development and evaluation of interventions for the prevention of childhood obesity in a multi-ethnic population: the Born in Bradford NHS Research Programme |
| Amount | £1,999,300 (GBP) |
| Funding ID | RP-PG-0407-10044 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Developmental overnutrition, DNA methylation and offspring cardiovascular health |
| Amount | £100,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Do epigenetic markers contribute to the excess risk of diabetes and coronary heart disease in Indian Asians? |
| Amount | £196,086 (GBP) |
| Funding ID | 082464/Z/07/C |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Do measures in blood cord predict long term offspring phenotype |
| Amount | £497,019 (GBP) |
| Funding ID | 094311 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Does mother's dietary intake during pregnancy influence offspring brain development and therefore cognitive ability? |
| Amount | £167,061 (GBP) |
| Funding ID | 084668 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Dysfunction of insulin signalling in type 2 diabetes and cardiovascular disease: a molecular and genetic pathway approach |
| Amount | £258,834 (GBP) |
| Funding ID | PG/10/008/28186 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | EU FP7 IRSES Genomic and Epigenomic Complex Disease Epidemiology |
| Amount | £757,671 (GBP) |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Early life determinants of blood pressure patterns in young adults |
| Amount | £495,353 (GBP) |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Epigenetic pathways to conduct problem trajectories: the role of prenatal and environmental risk exposures |
| Amount | £1,100,000 (GBP) |
| Organisation | National Institute of Child Health (NICH) |
| Sector | Academic/University |
| Country | Pakistan |
| Start | |
| Description | European Research Council Advanced Grant (Understanding health across the lifecourse: an integrated developmental approach) |
| Amount | £2,162,020 (GBP) |
| Funding ID | 269874 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | |
| Description | Explaining the association between type 2 diabetes and coronary heart disease in older men and women using two linked epidemiological studies: ¬ the role of novel risk factors |
| Amount | £84,075 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Exploiting SNP data in epidemiology and genetics through multivariate analysis of complex traits |
| Amount | $460,517 (AUD) |
| Organisation | National Health and Medical Research Council |
| Sector | Public |
| Country | Australia |
| Start | |
| Description | Fatty Liver: Inhibition of Progression (FLIP) programme (6m euros across 17 participants) |
| Amount | £2,000,000 (GBP) |
| Funding ID | 241762 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Funding to establish a capacity building doctoral training centre populations, pathways and molecules: mathematical and statistical approaches (10 four (1+3) year Ph.D. studentships (BCSBmed). |
| Amount | £823,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Galobardes B (Research Fellow) Wellcome Trust Intermediate Clinical Fellowship in life course inequalities in asthma: estimating its burden and the understanding of its aetiology. |
| Amount | £329,640 (GBP) |
| Funding ID | 089979 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Genetic and epigenetic determinants of obesity in Inda |
| Amount | £195,000 (GBP) |
| Funding ID | 083541 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Genetic predictors of blood antioxidant levels and the risk of AMD |
| Amount | £45,777 (GBP) |
| Organisation | Macular Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Genetic risk factors for cardiovascular disease in the British Women's Heart and Health Study |
| Amount | £163,757 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Genetic variation and gene-environmental influences in autistic-like traits |
| Amount | £69,434 (GBP) |
| Organisation | Autistica |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Genome-wide association study of maternal pregnancy phenotypes and later-life maternal and offspring vascular and metabolic phenotypes |
| Amount | £2,306,620 (GBP) |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Identification and Validation of Epigenetic Variation in ALSPAC. |
| Amount | £155,905 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Identification of normal and at risk trajectories of blood pressure in rpegnancy in relation to offspring perinatal health and childhood development |
| Amount | £345,701 (GBP) |
| Funding ID | MR/J011932/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Inferring Epidemiological Causality using Mendelian Randomisation |
| Amount | £476,228 (GBP) |
| Funding ID | G0601625 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Jago R (Research fellow). Parental and home environment influences on youth physical activity and screen-viewing: Preventing childhood obesity. NIHR Career Development Fellowship |
| Amount | £379,000 (GBP) |
| Funding ID | CDF-2009-02-14 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Joint UK Research Council Funded as part of the Lifelong Health and Wellbeing - Phase 3 initiative (The menopausal transition and healthy ageing and wellbeing) |
| Amount | £1,502,949 (GBP) |
| Funding ID | G1001357 |
| Organisation | Research Councils UK (RCUK) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Lifelong Health and Wellbeing (joint UKRCs) |
| Amount | £1,502,949 (GBP) |
| Funding ID | G1001357 |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Regional Centre London |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2011 |
| End | 08/2016 |
| Description | Luisa Zuccolo (Post Doctoral Research Fellow). Prenatal alcohol exposure, childhood development and teenage drinking: a study of trans-generational effects. |
| Amount | £417,352 (GBP) |
| Funding ID | G0902144 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MRC Integrative Epidemoilogy Unit. |
| Amount | £12,000,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2023 |
| Description | MRC Research grant (Mitochondrial DNA) |
| Amount | £384,038 (GBP) |
| Funding ID | MR/K002767/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2013 |
| End | 05/2016 |
| Description | Mapping phenotypic to genetic variability in the High Bone Mass Study |
| Amount | £355,425 (GBP) |
| Funding ID | 20000 |
| Organisation | Versus Arthritis |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 12/2018 |
| Description | Maternal thyroid status and offspring development |
| Amount | £222,383 (GBP) |
| Funding ID | ETM/97 |
| Organisation | Chief Scientist Office |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Measurement and modeling of functional trajectories across the life course (cross-unit appointments) |
| Amount | £280,134 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Mitochondrial DNA copy number as a phenotypic trait for human diseases in genetic epidemiological studies |
| Amount | £384,038 (GBP) |
| Funding ID | MR/K002767/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Modifiable early life determinants of adolescent NAFLD and its association with metabolic and vascular traits |
| Amount | £130,493 (GBP) |
| Funding ID | PG/11/33/28794 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Molecular Epidemiology. Postdoctoral fellowships in molecular epidemiology. |
| Amount | £840,000 (GBP) |
| Funding ID | OCAY-12-325 |
| Organisation | Oak Foundation |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | |
| Description | Molecular, genetic and lifecourse epidemiology. PhD programme to provide 3 PhD students per year for 6 years. |
| Amount | £2,900,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | NHMRC |
| Amount | $674,010 (AUD) |
| Funding ID | APP1043178 |
| Organisation | National Health and Medical Research Council |
| Sector | Public |
| Country | Australia |
| Start | 01/2013 |
| End | 12/2015 |
| Description | NIHR Public Health Research Programme (A cluster randomised controlled trial of a primary school-based intervention to increase levels of physical activity, decrease sedentary behaviour and improve diet) |
| Amount | £1,464,457 (GBP) |
| Funding ID | PHR/09/3005/04 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Obstetric, lifestyle and genetic determinants of atherosclerosis, fat mass, insulin, glucose and lipid levels in early middle-age |
| Amount | £882,350 (GBP) |
| Funding ID | SP/07/008/24066 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Occurrence and determinants of adolescent Non-Alcoholic Fatty Liver Disease (NAFLD) |
| Amount | £185,776 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Overseas PhD studentship to Osama Al-Ghamdi |
| Amount | £80,700 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | PROACTIV: PaRental influences On physical ACTIVity and screen viewing in young children |
| Amount | £237,731 (GBP) |
| Funding ID | PG/11/51/28986 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Pregnancy changes and future health of mother and offspring |
| Amount | £64,650 (GBP) |
| Funding ID | WT094529MA |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Pregnancy changes and future health of mother and offspring |
| Amount | £64,650 (GBP) |
| Funding ID | WT094529MA |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2012 |
| End | 06/2013 |
| Description | R Freathy -Metzger BE, Cox NJ. Maternal and offspring genetics in fetal and childhood growth. Wellcome Trust (Sir Henry Wellcome Postdoctoral Fellowship) |
| Amount | £250,000 (GBP) |
| Funding ID | 085541 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | RES-060-23-0011 An examination of the impact of family socio-economic status on outcomes in late childhood and adolescence |
| Amount | £3,604,228 (GBP) |
| Funding ID | ES/E00234X/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Santos AC (Postdoctoral Research Fellow). Desenvolvimento da obesidade na infância (Development of obesity in infancy). €225,000/Portugese Research Council |
| Amount | £225,000 (GBP) |
| Organisation | New University of Lisbon |
| Department | Foundation for Science and Technology |
| Sector | Academic/University |
| Country | Portugal |
| Start | |
| Description | Self-harm with and without suicidal intent in adolescence: causes and consequences - the ALSPAC cohort |
| Amount | £211,248 (GBP) |
| Funding ID | MR/J012661/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Smoking, DNA methylation at F2RL3 and cardiovascular disease risk |
| Amount | £15,540 (GBP) |
| Organisation | University of Bristol |
| Department | MRC Centre for Causal Analyses in Translational Epidemiology |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 12/2012 |
| End | 08/2013 |
| Description | Socioeconomic inequalities in cardiovascular disease risk over the life course and in different generations |
| Amount | £380,000 (GBP) |
| Organisation | Research Council of Norway |
| Sector | Public |
| Country | Norway |
| Start | |
| Description | Socioeconomic inequalities in cardiovascular disease risk over the life course and in different generations |
| Amount | £360,000 (GBP) |
| Organisation | Research Council of Norway |
| Sector | Public |
| Country | Norway |
| Start | 07/2012 |
| End | 06/2015 |
| Description | Specific project: datamining developments to identify members of a newly defined category of QTLs: splice-translational efficiency polymorphisms (STEPS), (capacity building studentship in bioinformatics) |
| Amount | £79,012 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Stability and integrity of microbiome sampling |
| Amount | £24,150 (GBP) |
| Organisation | University of Bristol |
| Department | MRC Centre for Causal Analyses in Translational Epidemiology |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 12/2012 |
| End | 08/2013 |
| Description | The 1958 Birth Cohort Biomedical Resource - faciliating access to data and samples and enhancing future utility |
| Amount | £1,489,639 (GBP) |
| Funding ID | G1001799 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | The Genetic Epidemiology of Atopic Dermatitis |
| Amount | £477,733 (GBP) |
| Funding ID | MR/J012165/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | The Healing Foundation UK Cleft Gene Bank |
| Amount | £2,396,169 (GBP) |
| Organisation | University of Manchester |
| Department | Healing Foundation (Charity for people with disfigurement and visible loss of function) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | The causal role of the nutritionally regulated insulin-like growth factor system in prostate cancer: Mendelian randomization study |
| Amount | £224,387 (GBP) |
| Funding ID | 2011/419 |
| Organisation | World Cancer Research Fund |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | |
| Description | The contribution of maternal obesity and gestational weight gain to preschool child obesity. Long-term follow-up of the LIMIT RCT. |
| Amount | $1,700,000 (AUD) |
| Organisation | National Health and Medical Research Council |
| Sector | Public |
| Country | Australia |
| Start | |
| Description | The long-term effects of increased alcohol availability: a natural experiment. |
| Amount | 4,030,000 kr (SEK) |
| Organisation | Government of Sweden |
| Sector | Public |
| Country | Sweden |
| Start | 01/2013 |
| End | 12/2016 |
| Description | The menopausal transition and healthy ageing and wellbeing |
| Amount | £1,502,949 (GBP) |
| Funding ID | G1001357 |
| Organisation | Medical Research Council (MRC) |
| Department | Lifelong Health and Wellbeing (LLHW) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | The public health importance of vitamin D: the causal effect of intrauterine and lifetime exposure to vitamin D on metabolic and vascular traits |
| Amount | £1,382,920 (GBP) |
| Funding ID | G0701603 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | The relationship of the menopausal transition to healthy ageing and chronic disease risk |
| Amount | £1,226,786 (GBP) |
| Funding ID | WT092830M |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | The utility of biomarkers for non-alcoholic fatty liver disease in adolescents |
| Amount | £548,636 (GBP) |
| Funding ID | G0801456 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2009 |
| End | 09/2012 |
| Description | Twins UK (2012-2015) - An Epidemiological and Genomic resource |
| Amount | £1,500,000 (GBP) |
| Funding ID | 099194 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Using Mendelian Randomisation to Establish the Causal Role of Cigarette Smoking in Anxiety and Depression |
| Amount | £110,594 (GBP) |
| Funding ID | MR/J01351X/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Validation and Replication of Variants in Predicted microRNA Binding Sites and their Effect on mRNA Expression Levels. |
| Amount | £14,516 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Vitamin D as a (causal) determinant of insulin resistance and diabetes? An analysis of three UK based prospective studies |
| Amount | £195,540 (GBP) |
| Funding ID | 10/0004071 |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Vitamin D as a (causal) determinant of insulin resistance and diabetes? An analysis of three UK based prospective studies. |
| Amount | £195,540 (GBP) |
| Funding ID | 10/0004071 |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | WT Resource award B638 SSCM.RJ5193 'ALSPAC: Request for funds to enhance this detailed biomedical resource with obstetric & perinatal data from medical records' |
| Amount | £121,384 (GBP) |
| Funding ID | 087997 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 04/2011 |
| Description | Wellcome Trust Resources Award |
| Amount | £1,481,389 (GBP) |
| Funding ID | WT101597MA |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2014 |
| End | 01/2018 |
| Description | Wellcome Trust call for Genome Wide Association Studies (Genome-wide association study of maternal pregnancy phenotypes and later-life maternal and offspring vascular and metabolic phenotypes) |
| Amount | £2,028,579 (GBP) |
| Funding ID | 088806 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | 25(OH)D GWAS in children |
| Organisation | University of Queensland |
| Department | Genetic Epidemiology Laboratory |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | We are leading this collaboration which includes teams from Australia (QIMR and Perth) and the US (NHANES) who are working with us to identify genetic variants associated with 25(OH)D, calcuim, phosphate and PTH in children. |
| Collaborator Contribution | Replication sample for our GWAS, which will be published Replication of our GWAS analysis, which will be published |
| Impact | Draft first publication currently being circulated amongst co-authors. The collaboration is multidisciplinary including epidemiologists, statisticians, geneticists and bioinformaticians. |
| Start Year | 2010 |
| Description | 25(OH)D GWAS in children |
| Organisation | University of Western Australia |
| Department | School of Population Health |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | We are leading this collaboration which includes teams from Australia (QIMR and Perth) and the US (NHANES) who are working with us to identify genetic variants associated with 25(OH)D, calcuim, phosphate and PTH in children. |
| Collaborator Contribution | Replication sample for our GWAS, which will be published Replication of our GWAS analysis, which will be published |
| Impact | Draft first publication currently being circulated amongst co-authors. The collaboration is multidisciplinary including epidemiologists, statisticians, geneticists and bioinformaticians. |
| Start Year | 2010 |
| Description | A review of life time risk factors for mortality |
| Organisation | University College London |
| Department | Centre for Longitudinal Studies |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Aim to review evidence for risk factors for mortality across the life time using evidence from existing birth cohorts. Two leads, one Bristol. |
| Impact | Journal publication accepted Biomedical leads for Joint Forces conference on Mortality & Longevity. |
| Start Year | 2009 |
| Description | A review of life time risk factors for mortality |
| Organisation | University College London |
| Department | MRC Unit for Lifelong Health and Ageing |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Aim to review evidence for risk factors for mortality across the life time using evidence from existing birth cohorts. Two leads, one Bristol. |
| Impact | Journal publication accepted Biomedical leads for Joint Forces conference on Mortality & Longevity. |
| Start Year | 2009 |
| Description | ANDIPOGEN |
| Organisation | McGill University |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Analytical and methodological, through the organisation and undertaking of analyses concerning the genetics of adiponectin levels. |
| Collaborator Contribution | Development of sample collections for the extended analysis of the genetics of circulating adiponectin. |
| Impact | Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, Perry JR et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genetics 2009 5:e1000768. Heid IM, Henneman P, Hicks A, Coassin S, Winkler T, Aulchenko YS et al. Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis 2010;208:412-20. EGG/EAGLE Sovio U, Bennett AJ, Millwood IY, Molitor J, O'Reilly PF, Timpson NJ et al. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. PLoS Genet 2009;5:e1000409. Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ et al. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics. 2010;42:430-5. Sovio U, Mook-Kanamori D, Warrington N, Lawrence R, Briollais L, Palmer C, et al. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: The complex nature of genetic association through growth and development. PLoS Genetics 2010; 7(2):e1001307. |
| Start Year | 2009 |
| Description | ARIES (Accessible Resource for Integrated Epidemiological Studies) |
| Organisation | The International Centre for Life |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | CAiTE leads this collaboration. |
| Collaborator Contribution | Data sharingData sharing |
| Impact | The project began quite recently, so none so far. |
| Start Year | 2011 |
| Description | ARIES (Accessible Resource for Integrated Epidemiological Studies) |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | CAiTE leads this collaboration. |
| Collaborator Contribution | Data sharingData sharing |
| Impact | The project began quite recently, so none so far. |
| Start Year | 2011 |
| Description | Adolescent onset conduct problems: a biopsychosocial model of risk. |
| Organisation | King's College London |
| Department | MRC Social Genetic and Developmental Psychiatry Centre (SDGP) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of Genetic information and data |
| Impact | Publications |
| Start Year | 2009 |
| Description | Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study |
| Organisation | Icelandic Heart Association (IHA) |
| Country | Iceland |
| Sector | Charity/Non Profit |
| PI Contribution | We designed the study, conducted all statistical analyses and drafted a manuscript. |
| Collaborator Contribution | They made available to us DNA from AGES participants for SNP genotyping. They made also available to us a large number of phenotypes including Hemoglobin A1c, height, weight, body mass index (BMI, defined as weight (kg)/height squared (m2)), waist circumference, fat free mass (measured by bioimpedence), systolic blood pressure, diastolic blood pressure, fasting glucose, fasting insulin, cholesterol, HDL, LDL, triglycerides and coronary calcium. Blood pressure and anthropometric data included BMI, waist circumference and fat-free mass. Fasting blood glucose, total cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides. Fasting insulin and two binary traits, hypertension and type 2 diabetes. |
| Impact | Santiago Rodriguez, Gudny Eiriksdottir, Tom R. Gaunt, Tamara B. Harris, Lenore J. Launer, Vilmundur Gudnason, Ian N. M. Day. 2010. IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetes. Growth Hormone & IGF Research 20: 310-318. |
| Start Year | 2007 |
| Description | An investigation of genetic epidemiological risk factors for psychotic like symptoms in adolescent birth cohort. |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | ???? |
| Impact | Publication |
| Description | Association of maternal diabetes genes with offspring adiposity as a test of the developmental overnutrition hypothesis |
| Organisation | Danish Ministry of Health |
| Department | Danish National Birth Cohort |
| Country | Denmark |
| Sector | Public |
| PI Contribution | Analyses completed in ALSPAC. Key aims of the project are to examine independent (of offspring genotype) associations of maternal type 2 diabetes related genetic variants with offspring weight, BMI, waist and fat mass in infancy and childhood |
| Impact | Paper due for submission imminently. |
| Start Year | 2008 |
| Description | Association of maternal diabetes genes with offspring adiposity as a test of the developmental overnutrition hypothesis |
| Organisation | Erasmus University Rotterdam |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Analyses completed in ALSPAC. Key aims of the project are to examine independent (of offspring genotype) associations of maternal type 2 diabetes related genetic variants with offspring weight, BMI, waist and fat mass in infancy and childhood |
| Impact | Paper due for submission imminently. |
| Start Year | 2008 |
| Description | Association of maternal diabetes genes with offspring adiposity as a test of the developmental overnutrition hypothesis |
| Organisation | Norwegian National Birth Cohort |
| Country | Norway |
| Sector | Public |
| PI Contribution | Analyses completed in ALSPAC. Key aims of the project are to examine independent (of offspring genotype) associations of maternal type 2 diabetes related genetic variants with offspring weight, BMI, waist and fat mass in infancy and childhood |
| Impact | Paper due for submission imminently. |
| Start Year | 2008 |
| Description | Association of maternal diabetes genes with offspring adiposity as a test of the developmental overnutrition hypothesis |
| Organisation | University of Exeter |
| Department | College of Social Sciences and International Studies |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Analyses completed in ALSPAC. Key aims of the project are to examine independent (of offspring genotype) associations of maternal type 2 diabetes related genetic variants with offspring weight, BMI, waist and fat mass in infancy and childhood |
| Impact | Paper due for submission imminently. |
| Start Year | 2008 |
| Description | Association of maternal diabetes genes with offspring adiposity as a test of the developmental overnutrition hypothesis |
| Organisation | University of Western Australia |
| Department | Raine Medical Research Foundation |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Analyses completed in ALSPAC. Key aims of the project are to examine independent (of offspring genotype) associations of maternal type 2 diabetes related genetic variants with offspring weight, BMI, waist and fat mass in infancy and childhood |
| Impact | Paper due for submission imminently. |
| Start Year | 2008 |
| Description | Born in Bradford |
| Organisation | Bradford Institute for Health Research (BIHR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are collaborating with the Born in Bradford cohort to examine the association of maternal 25(OH)D in pregnancy with pregnancy complications. |
| Collaborator Contribution | Advances understanding of the relationship of 25(OH)D to pregnancy complications. Output includes research journal publications. |
| Impact | Two papers are currently at advanced darft status. One examines associations with results from oral glucose tolerance tests in pregnancy and the second with hypertensive disorders of pregnancy. |
| Start Year | 2010 |
| Description | Bristol CaRE collaboration |
| Organisation | National Heart, Lung, and Blood Institute (NHLBI) |
| Department | Candidate gene Association Resource (CARe) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data sharing within consortium. |
| Collaborator Contribution | Data sharing within consortium. |
| Impact | Disciplines: Statistical genetics, Genetic epidemiology, Molecular Genetics, Bioinformatics. Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, M Maloney C, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou C, Boer A, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, J Meyer N, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszweski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmuda JM, Clarke R, Balmforth AJ, Danesh J, Day IN, Schork NJ, de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, D Christie J, Berenson GS, Murray SS, Illig T, Dorn GW 2nd, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, Marz W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ; Hugh Watkins on behalf of PROCARDIS; Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT; Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group; Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet. 2011 Jan 7;88(1):6-18. Epub 2010 Dec 30. |
| Start Year | 2010 |
| Description | C-Reactive Protein Coronary Heart Disease Genetics Collaboration ( |
| Organisation | University of Cambridge |
| Department | Department of Public Health and Primary Care |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Involved in the establishment of the collaboration Intellectual contribution to all papers Contribution of data and analyses from cohorts maintained at University of Bristol |
| Collaborator Contribution | Sharing of intellectual ideas, expertise and data |
| Impact | Three papers published and others currently on going. 1. Danesh J, Hingorani A, Wensley F, Casas JP, Smeeth L, Samani NJ, Hall A, Whincup P, Morris R, Lawlor DA, Davey Smith G, Timpson NJ, Ebrahim S, Brown M, Sandhu M, Reiner A, Psaty B, Lange L, Cushman M, Tracy R, Nordestgaard BG, Tybjaerg-Hansen A, Zacho J, Hung J, Thompson P, Beilby J, Palmer LJ, Fowkes, Lowe G, Tzoulaki I, Kumari M, Overvad K, Khaw KT, Benjamin E, Chiodini B, Franzosi M, Norman PE, Hankey GJ, Jamrozik K, Rimm E, Pai J, Psaty B, Heckbert S, Bis J, Yusuf S, Anand S, Engort J, Collins R, Melander O, Berglund G, Ladenvall P, Johansson L, Jansson J-H, Hallmans G, Humphries S, Manson J, Saleheen D, Danesh J, Frossard P, Sattar N, Robertson M, Shepherd J, Schaefer E, Hofman A, Witteman JCM, Kardys I, de Faire U, Bennet A, O'Reilly D, McMahon A, Packard C, Clarke R, Kumari M, Greenland P, Manson J, Casas JP, Franzosi M, Nordestgaard BG, Smeeth L, Bowden J, Di Angelantonio E, Shah T, Thompson S, Verzilli C, Walker M, Whittaker J, Yusuf S. Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomization. European Journal of Epidemiology 2008;23:531-540 2. Burgess S, Thompson SG, Andrews G, Samani NJ, Hall A, Whincup P, Morris R, Lawlor DA, Davey Smith G, Timpson N, Ebrahim S, Ben-Shlomo Y, Brown M, Ricketts S, Sandhu M, Reiner A, Psaty B, Lange L, Cushman M, Hung J, Thompson P, Beilby J, Warrington N, Palmer LJ, Nordestgaard BG, Tybjaerg-Hansen A, Zacho J, Wu C, Lowe G, Tzoulaki I, Kumari M, Sandhu M, Yamamoto JF, Chiodini B, Franzosi M, Hankey GJ, Jamrozik K, Palmer L, Rimm E, Pai J, Heckbert S, Bis J, Anand S, Engert J, Collins R, Clarke R, Melander O, Berglund G, Ladenvall P, Johansson L, Jansson JH, Hallmans G, Humphries S, Manson J, Watkins H, Clarke R, Hopewell J, Saleheen D, Frossard R, Sattar N, Robertson M, Shepherd J, Schaefer E, Hofman A, Witteman JC, Kardys I de Faire U, Bennet A, Ford I, Packard C, Casas JP, Smeeth L, Wensley F, Bowden J, Di Angelantonio E, Engert J, Gao P, Shah T, Verzilli C, Walker M, Whittaker J, Hingorani A, Danesh J. Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables. Statistics in Medcine 2010; 29:1298-1311 3. C-Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC). Is C-reactive protein causally related to coronary heart disease? Mendelian randomization analyses based on individual participant data. BMJ 2010; in press |
| Start Year | 2008 |
| Description | CHICOS |
| Organisation | CHICOS: Developing a Child Cohort Research Strategy for Europe |
| Country | European Union (EU) |
| Sector | Academic/University |
| PI Contribution | Overall aim is to improve child health across Europe by developing an integrated strategy for mother-child cohort research in Europe. Methodologically we are working on ways of harmonising data and comparing results between and, where appropriate, pooling data from all European mother-child cohorts. I lead the work on child obesity and cardiometabolic health. I contribute data and/or analyses results for reserach that other partners lead in other research areas. |
| Collaborator Contribution | Partners contribute data or results from analyses for research that I lead on child obesity and cariometabolic health. |
| Impact | Publications currently being drafted |
| Start Year | 2010 |
| Description | Comparing associations of SEP with change in height from birth to age 9 between a LMIC and HIC cohort |
| Organisation | Federal University of Pelotas (UFPel) |
| Department | 1982 Pelotas Birth Cohort |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Aim to compare the assocations of socioeonomic position with growth in lenght/height between birth and age 9. Bristol led. |
| Impact | Two papers with each cohort, but referring to each other at end, at almost final draft stage. |
| Start Year | 2008 |
| Description | Comparing growth in cohorts from LMIC and HIC |
| Organisation | Federal University of Pelotas (UFPel) |
| Department | 1982 Pelotas Birth Cohort |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Aim to compare childhood growth curves for height and weight (from birth to age 9) between countries with very different socioeconomic backgrounds. Lead by ALSPAC |
| Collaborator Contribution | Provision of data |
| Impact | Analyses within each cohort complete, paper being drafted. |
| Start Year | 2008 |
| Description | Copenhagen Heart Study |
| Organisation | Copenhagen University Hospital |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Key contribution in the analysis of data and the writing of research papers pertaining to the undertaking of causal analyses. This has included research papers on blood pressure and BMI, depression, C-reactive protein and BMI. |
| Collaborator Contribution | A huge population based repository of epidemiological and clinical data which has been a crucial contribution to the undertaking and development of Mendelian randomisation studies. |
| Impact | Timpson NJ, Nordestgaard BG, Harbord RM, Zacho J, Frayling TM, Tybjaerg-Hansen A, et al. C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. Int J Obesity 2010, doi: 10.1038/ijo.2010.137. Timpson NJ, Harbord R, Davey Smith G, Zacho J, Tybjaerg-Hansen, Nordestgaard BG. Does Greater Adiposity Increase Blood Pressure And Hypertension Risk? Mendelian Randomization Using Fto/Mc4r Genotype. Hypertension 2009; 54: 84-90. Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53 221 adults. Debbie A. Lawlor1,2, Roger M. Harbord2,1, Anne Tybjaerg-Hansen3,4,5, Tom M. Palmer1,2, Jeppe Zacho4,5,6, Marianne Benn4,5,6, Nicholas J. Timpson1,2, George Davey Smith1,2 & Børge G. Nordestgaard4,5,6 doi: 10.1111/j.1365-2796.2011.02343.x 2011 The Association for the Publication of the Journal of Internal Medicine 525 |
| Start Year | 2008 |
| Description | Developing family based methods for causal analysis in life course epidemiology |
| Organisation | University College London |
| Department | MRC Unit for Lifelong Health and Ageing |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Aim to review, develop and document the theoretical underpinning and statistical methods for using family based studies to improve causal inference in life course epidemiology. Bristol lead |
| Impact | Family matters - designing, analysing and understanding family-based studies in life course epidemiology (OUP 2009). Several workshops |
| Start Year | 2007 |
| Description | Developing family based methods for causal analysis in life course epidemiology |
| Organisation | University of Aberdeen |
| Department | Institute of Applied Health Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Aim to review, develop and document the theoretical underpinning and statistical methods for using family based studies to improve causal inference in life course epidemiology. Bristol lead |
| Impact | Family matters - designing, analysing and understanding family-based studies in life course epidemiology (OUP 2009). Several workshops |
| Start Year | 2007 |
| Description | Diet in relation to increasing body fatness in childhood. |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data |
| Impact | Publications |
| Description | Diet, IGF and cancer risk: an inter-generational investigation. |
| Organisation | University of Bristol |
| Department | School of Social and Community Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of Dietary information and blood samples from Mothers and children. |
| Impact | Publications. |
| Description | Disordered eating in adolesence: a longitudinal study of risk factors |
| Organisation | King's College London |
| Department | Institute of Psychiatry, Psychology & Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data |
| Impact | Publications and Phd project |
| Start Year | 2006 |
| Description | EAGLE |
| Organisation | Center for Research in Environmental Epidemiology |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Early Genetics and Lifecourse Epidemiology Consortium (EAGLE) is a large collaboration of cohorts interested in genetic and early life determinants of childhood phenotypes. I make key contributions using data from ALSPAC and BiB in relation to determinants of cardiometabolic phenotypes and in relation to pregnancy phenotypes. |
| Collaborator Contribution | For projects that I lead partners to the collaborations follow analyses plans if they are contributing to discovery analyses and, where appropriate, help by obtaining new data (e.g. SNP data) and completing analyses for replication. |
| Impact | Formed in 2010 and ALSPAC has been a key contributing discovery cohort (unique in being the only cohort with GWAS in mothers and offspring) from the start. Large number of publications (see EAGLE website) |
| Start Year | 2010 |
| Description | EAGLE |
| Organisation | Erasmus University Rotterdam |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Early Genetics and Lifecourse Epidemiology Consortium (EAGLE) is a large collaboration of cohorts interested in genetic and early life determinants of childhood phenotypes. I make key contributions using data from ALSPAC and BiB in relation to determinants of cardiometabolic phenotypes and in relation to pregnancy phenotypes. |
| Collaborator Contribution | For projects that I lead partners to the collaborations follow analyses plans if they are contributing to discovery analyses and, where appropriate, help by obtaining new data (e.g. SNP data) and completing analyses for replication. |
| Impact | Formed in 2010 and ALSPAC has been a key contributing discovery cohort (unique in being the only cohort with GWAS in mothers and offspring) from the start. Large number of publications (see EAGLE website) |
| Start Year | 2010 |
| Description | EAGLE |
| Organisation | Harvard University |
| Department | Harvard T.H. Chan School of Public Health |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Early Genetics and Lifecourse Epidemiology Consortium (EAGLE) is a large collaboration of cohorts interested in genetic and early life determinants of childhood phenotypes. I make key contributions using data from ALSPAC and BiB in relation to determinants of cardiometabolic phenotypes and in relation to pregnancy phenotypes. |
| Collaborator Contribution | For projects that I lead partners to the collaborations follow analyses plans if they are contributing to discovery analyses and, where appropriate, help by obtaining new data (e.g. SNP data) and completing analyses for replication. |
| Impact | Formed in 2010 and ALSPAC has been a key contributing discovery cohort (unique in being the only cohort with GWAS in mothers and offspring) from the start. Large number of publications (see EAGLE website) |
| Start Year | 2010 |
| Description | EAGLE |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Early Genetics and Lifecourse Epidemiology Consortium (EAGLE) is a large collaboration of cohorts interested in genetic and early life determinants of childhood phenotypes. I make key contributions using data from ALSPAC and BiB in relation to determinants of cardiometabolic phenotypes and in relation to pregnancy phenotypes. |
| Collaborator Contribution | For projects that I lead partners to the collaborations follow analyses plans if they are contributing to discovery analyses and, where appropriate, help by obtaining new data (e.g. SNP data) and completing analyses for replication. |
| Impact | Formed in 2010 and ALSPAC has been a key contributing discovery cohort (unique in being the only cohort with GWAS in mothers and offspring) from the start. Large number of publications (see EAGLE website) |
| Start Year | 2010 |
| Description | EAGLE |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Early Genetics and Lifecourse Epidemiology Consortium (EAGLE) is a large collaboration of cohorts interested in genetic and early life determinants of childhood phenotypes. I make key contributions using data from ALSPAC and BiB in relation to determinants of cardiometabolic phenotypes and in relation to pregnancy phenotypes. |
| Collaborator Contribution | For projects that I lead partners to the collaborations follow analyses plans if they are contributing to discovery analyses and, where appropriate, help by obtaining new data (e.g. SNP data) and completing analyses for replication. |
| Impact | Formed in 2010 and ALSPAC has been a key contributing discovery cohort (unique in being the only cohort with GWAS in mothers and offspring) from the start. Large number of publications (see EAGLE website) |
| Start Year | 2010 |
| Description | EAGLE |
| Organisation | University of Southampton |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Early Genetics and Lifecourse Epidemiology Consortium (EAGLE) is a large collaboration of cohorts interested in genetic and early life determinants of childhood phenotypes. I make key contributions using data from ALSPAC and BiB in relation to determinants of cardiometabolic phenotypes and in relation to pregnancy phenotypes. |
| Collaborator Contribution | For projects that I lead partners to the collaborations follow analyses plans if they are contributing to discovery analyses and, where appropriate, help by obtaining new data (e.g. SNP data) and completing analyses for replication. |
| Impact | Formed in 2010 and ALSPAC has been a key contributing discovery cohort (unique in being the only cohort with GWAS in mothers and offspring) from the start. Large number of publications (see EAGLE website) |
| Start Year | 2010 |
| Description | EAGLE |
| Organisation | University of Western Australia |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Early Genetics and Lifecourse Epidemiology Consortium (EAGLE) is a large collaboration of cohorts interested in genetic and early life determinants of childhood phenotypes. I make key contributions using data from ALSPAC and BiB in relation to determinants of cardiometabolic phenotypes and in relation to pregnancy phenotypes. |
| Collaborator Contribution | For projects that I lead partners to the collaborations follow analyses plans if they are contributing to discovery analyses and, where appropriate, help by obtaining new data (e.g. SNP data) and completing analyses for replication. |
| Impact | Formed in 2010 and ALSPAC has been a key contributing discovery cohort (unique in being the only cohort with GWAS in mothers and offspring) from the start. Large number of publications (see EAGLE website) |
| Start Year | 2010 |
| Description | EGG/EAGLE |
| Organisation | University of Amsterdam |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Contribution to the development and running of the consortium along with leading a series of core projects for this consortium - including the longitudinal analysis of genetic effects on BMI, eczema, sensitisation and allergy, etc. |
| Collaborator Contribution | Development of the largest base of paediatric samples with gwas data for the analysis and exploration of the genetics of growth, development and child base epidemiology. |
| Impact | Sovio U, Bennett AJ, Millwood IY, Molitor J, O'Reilly PF, Timpson NJ et al. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. PLoS Genet 2009;5:e1000409. Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ et al. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics. 2010;42:430-5. Sovio U, Mook-Kanamori D, Warrington N, Lawrence R, Briollais L, Palmer C, et al. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: The complex nature of genetic association through growth and development. PLoS Genetics 2010; 7(2):e1001307. |
| Start Year | 2008 |
| Description | Examing the causal effects of breast feeding on IQ, obesity and blood pressure |
| Organisation | Federal University of Pelotas (UFPel) |
| Department | 1982 Pelotas Birth Cohort |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | To examine the role of cross-cohort comparisons for dealing with confounding and improving causal inference using breast-feeding and later outcomes as an example. Lead by ALSPAC |
| Impact | Paper under review |
| Start Year | 2008 |
| Description | Examining the causal association of maternal adiposity in pregnancy with offspring cognition & behaviour |
| Organisation | Erasmus University Rotterdam |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Aim is to compare different methods of examining causality and determine whether variation in maternal BMI in pregnancy is related to offspring cognitive function and behaviours. Led by ALSPAC |
| Impact | Advanced draft with co-authors |
| Start Year | 2009 |
| Description | Examining the causal association of maternal adiposity in pregnancy with offspring cognition & behaviour |
| Organisation | Federal University of Pelotas (UFPel) |
| Department | 1982 Pelotas Birth Cohort |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Aim is to compare different methods of examining causality and determine whether variation in maternal BMI in pregnancy is related to offspring cognitive function and behaviours. Led by ALSPAC |
| Impact | Advanced draft with co-authors |
| Start Year | 2009 |
| Description | Functional trajectories Across the Life Course (FALCon) |
| Organisation | University College London |
| Department | MRC Unit for Lifelong Health and Ageing |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Aim is to develop methods for describing functional trajectories across life course from birth to age 90s and exploring the determinants of these by using UK cohorts that cover different time periods in the life course. Joint Bristol/ lead |
| Impact | MRC funded project grant. 4 papers submitted and 3 conference presentations. |
| Start Year | 2007 |
| Description | GBPGen - Global BP Genome Wide Collaboration |
| Organisation | Queen Mary University of London |
| Department | Barts and The London School of Medicine and Dentistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | study design, analysis and paper writing |
| Collaborator Contribution | Sharing of intellectual ideas, data and analyses |
| Impact | Papers:- 1) Common variation in the WNK1 gene and blood pressure in childhood: evidence from the Avon Longitudinal Study of Parents and Children. Hypertension 2008; 52:974-979. doi: 10.1161/hybertensioaha.108.118414, PMID:18809789. 2. The International Collaboration for Blood Pressure Genome-wide Association Studies. Common Polymorphisms Impacting Blood Pressure and Cardiovascular Disease in Diverse Populations Highlight Novel Biological Pathways. Nature Genetics 2010 (in press |
| Start Year | 2008 |
| Description | GEoCoDE |
| Organisation | European Commission |
| Country | European Union (EU) |
| Sector | Public |
| PI Contribution | CAiTE leads GEoCoDE. |
| Collaborator Contribution | Data sharing |
| Impact | 1. G Davey Smith, L Molloy, SM Ring, AR Ness, J MacLeod, D Evans, A Emond, G Lewis, K Tilling, J Donovan, J Tobias, B Glaser, R Burton, CL Relton, N Timpson, AJ Henderson, L Peltonen, J Lynch. The Avon Longitudinal study of parents and children: An international resource for population genomics and lifecourse epidemiology core programme support. Jan 2011-Dec 2013 MRC & Wellcome Trust 2. DA Lawlor, S Nelson, N Sattar, K Tilling, J Tobias, CL Relton, A Owen-Smith, J Donovan, D Kuh, SM Ring, G Davey Smith, C Propper, S Smith, I Beesley, A Fraser. The menopausal transition and healthy ageing and wellbeing. Joint UK Research Council funded as part of the Lifelong Health and Wellbeing - Phase 3 initiative. Sep 2011-Sep 2016 3. DA Lawlor, A Fraser, G Davey Smith, K Tilling, J Tobias, SM Ring, S Nelson, N Sattar, CL Relton, TM Palmer. The relationship of the menopausal transition to healthy ageing and chronic disease risk. May 2011-Apr 2015 Wellcome Trust 4. G Davey Smith, CL Relton, SE Ozanne, T Gaunt, SM Ring, D Evans, A Wipat, T Kirkwood, W Reik. ARIES - Accessible Resource for Integrated Epigenomic Studies. Sep 2011-Aug 2013 BBSRC 6. L Zuccolo. Prenatal alcohol exposure, childhood development and teenage drinking: a study of transgenerational effects. Sep 2010-Aug 2014 MRC Postdoctoral Fellowship, [Relton, Sponsor] 2. Relton CL, Davey Smith G. Future potential for the application of epigenetics in the prevention and treatment of common complex disease. PLoS Med 7(10):e1000356, 2010. 5. Timofeeva M, McKay JD, Davey Smith G, Johansson M, Byrnes G, Chabrier A, Relton CL, Ueland PM, Vollet SE, Midttun Ø, Nygård O, Slimani N, Boffetta P, Clavel-Chapelon F, Boutron-Ruault MC,Fagherazzi G, Kaaks R, Teucher B, Boeing H, Weikert C, Bueno-de-Mesquita HB, van Gils C, Peeters PHM, Agudo A, Barricarte A, Huerta JM, Rodríguez L, Sánchez MJ, Larrañaga N, Khaw KT, Wareham N, Allen NE, Travis RC, Gallo V, Norat T, Krogh V, Masala G, Panico S, Sacerdote C, Tumino R, Trichopoulou A, Lagiou P, Trichopoulos D, Rasmuson T, Hallmans G, Riboli E, Vineis P, Brennan P. Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels and risk of lung cancer in EPIC. Cancer Epidemiol Biomarkers Prev 2011, In Press. 6. Brion MJ, Lawlor DA, Matijasevich A, Horta BL, Anselmi L, Araújo CL, Menezes AM, Victora CG, Davey Smith G. What are the causal effects of breastfeeding on IQ, obesity and blood pressure? Evidence from comparing high-income with middle-income cohorts. Int J Epidemiol, In Press 7. Brion MJ, Victora CG, Matijasevich A, Horta BL, Anselmi L, Steer C, Menezes AM, Lawlor DA, Davey Smith G. Maternal smoking and child psychological problems: disentangling causal and noncausal effects. Pediatrics. 2010 Jul;126(1):e57-65. 16. Timpson NJ, Forouhi NG, Brion M-J, Harbord RM, Cook DG, Johnson P, McConnachie A, Morris RW, Rodriguez S, Luan J, Ebrahim S, Padmanabhan S, Watt G, Bruckdorfer KR, Wareham NJ2, Whincup PH, Chanock S, Sattar N, Lawlor DA, Davey Smith G. Genetic variation at the SLC23A1 locus is associated with circulating levels of Lascorbic acid (Vitamin C). Evidence from 5 independent studies with over 15000 participants. American Journal of Clinical Nutrition 2010;92:375-382. 17. Kinra S, Bowen LJ, Lyngdoh T, Prabhakaran D, Reddy KS, Ramakrishnan L, Gupta R, Bharathi AV, Vaz M, Kurpad AV, Davey Smith G, Ben-Shlomo Y, Ebrahim S. Sociodemographic patterning of non-communicable disease risk factors in rural India: a cross-sectional study. BMJ 2010;341:c4974. doi:10.1136/bmj.c4974. 18. Matijasevich A, Victora CG, Lawlor DA, Golding J, Menezes AMB, Araújo CL, Barros AJD, Santos IS, Barros FC, Davey Smith G. Association of socioeconomic position with maternal pregnancy and infant health outcomes in birth cohort studies from Brazil and the UK. Journal of Epidemiology and Community Health 2010 on line. doi:10.1136/jech.2010.108605. 19. Timpson NJ, Nordestgaard BG, Harbord RM, Zaccho J, Frayling TM, Tybjaerg-Hansen A, Davey Smith G. C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. International Journal of Obesity 2011; 35, 300-308. 20. Davies NM, Windmeijer F, Martin RM, Abdollahi MR, Davey Smith G, Lawlor DA, Ebrahim S, Day INM. Use of genotype frequencies in medicated groups to investigate prescribing: APOE and statins as a proof of principle. Clinical Chemistry 2010; on line. DOI: 10.1373/clinchem.2010.156356. 21. Ebrahim S, Kinra S, Bowen L, Andersen E, Ben-Shlomo Y, Lyngdoh T, Ramakrishnan L, Ahuja RC, Joshi P, Mohan Das S, Mohan M, Davey Smith G, Prabhakaran D, Reddy KS, for the Indian Migration Study Group. The Effect of Rural-to-Urban Migration on Obesity and Diabetes in India: A Cross-Sectional Study. PLoS Medicine 2010;7: DOI: e1000268. 22. Munafo MR, Freathy RM, Ring SM, St Pourcain B, Davey Smith G. Association of COMT Val108/158 MET Genotype and cigarette smoking in pregnant women. Nicotine and Tobacco Research 2010, doi: 10.1093/ntr/ntq209. 23. Brion M-J, Zeegers M, Jaddoe V, Verhulst F, Tiemeier H, Lawlor DA, Davey Smith G. Intrauterine effects of maternal prepregnancy overweight on child cognition and behaviour in 2 cohorts. Pediatrics 2011;127:e202-e211. 24. De Silva NMG , Freathy RM, Palmer TM, Donnelly LA, Luan J, Gaunt T, Langenberg C,, Weedon MN, Shields B, Knight BA, Ward K, Sandhu MS, Harbord RM, McCarthy MI, Davey Smith G, Ebrahim S, Hattersley AT, Wareham N, Lawlor DA, Morris AD, Palmer CNA, Frayling TM. Mendelian Randomization Studies do not Support a Role for Raised Circulating Triglyceride Levels influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance. Diabetes 2011, doi: 10.2337/db10-1317. 25. Barker A, Sharp SJ, Timpson NJ, Bouatia-Naki N, Warrington NM, Kanoni S, Beilin LJ, Brage S, Deloukas P, Evans DM, Grantved A, Hassanali N, Lawlor DA, Lecoeur C, Loos RJF, Lye SJ, McCarthy MI, Mori TA, Ndiaye NC, Newnham JP, Ntalla I, Pennell CE, St Pourcain B, Prokopenko I, Ring SM, Sattar N, Visvikis-Siest S, Dedoussis GV, Palmer LJ, Froguel P, Davey Smith G, Ekelund U, Wareham NJ, Langenberg C. Association of genetic loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes 2011, doi: 10.2337/db10-1575. 26. Sovio U, Mook-Kanamori DO, Warrington NM, Lawrence R, Briollais L, Palmer CNA, Cecil J, Sandling JK, Syvänen AC, Kaakinen M, Beilin LJ, Millwood IY, Bennett AJ, Laitinen J, Pouta A, Molitor J, Davey Smith G, Ben-Shlomo Y, Jaddoe VWV, Palmer LJ, Pennell CE, Cole TJ, McCarthy MI, Järvelin MR, Timpson NJ for the EGG Consortium. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: The complex nature of genetic association through growth and development. PLoS Genetics 2011, February; 7(2): e1001307; doi:10.1371/journal.pgen.1001307 27. Zabaneh D, Gaunt TR, Kumari M, Drenos F, Shah S, Berry D, Power C, Hypponen E, Shah T, Palmen J,Pallas J, Talmud PJ, Casas JP, Sofat R, Lowe G, Rumley A, Morris RW, Whincup PH, Rodriguez S, Ebrahim S, Marmot MG, Davey Smith G, Lawlor DA. Genetic Variants associated with von Willebrand Factor Levels in Health Men and Women Identified Using the Human CVD BeadChip. Annuals of Human Genetics 2011;75:456-467. 28. Kinra S, Andersen E, Ben-Shlomo Y, Bowen L, Lyngdoh T, Prabhakaran D, Reddy KS, Ramakrishnan L, Bharathi A, Vaz M, Kurpad A, Davey Smith G, Ebrahim S. Association between urban life-years and cardio-metabolic risk. Am J Epidemiol 2011, in press. 29. Taylor AE, Sandeep MN, Janipalli C, Giambartolomei C, Evans D, Kranthi Kumar MV, Vinay DG, Smitha P, Gupta V, Aruna M, Kinra S, Sullivan R, Bowen L, Timpson N, Davey Smith G, Dudbridge F, Prabhakaran D, Ben-Shlomo Y, Reddy KS, Ebrahim S. Associations of FTO and MC4R variants with obesity traits in Indians and the role of rural/urban environment as a possible effect modifier, Journal of Obesity 2011; doi:10.1155/2011/307542 30. Soler Artigas M, Wain LV, Repapi E, Obeidat M, Sayers I, Burton PR, Johnson T, Zhao JH, Albrecht E, Dominiczak AF, Kerr SM, Smith BH, Cadby G, Hui J, Palmer LJ, Hingorani AD, Wannamethee SG, Whincup PH, Ebrahim S, Davey Smith G, Barroso I, Loos RJL, Wareham NJ, Cooper C, Dennison E, Shaheen SO, Liu JZ, Marchini J, The NSHD Respiratory Study Team, Dahgam S, Naluai AT, Olin A-C, Karrasch S, Heinrich J, Schulz H, McKeever TM, Pavord ID, Heliövaara M, Ripatti S, Surakka I, Blakey JD, Kähönen M, Britton JR, Nyberg F, Holloway JW, Lawlor DA, Morris RW, James AL, Jackson CM, Hall IP, Tobin MD, and SpiroMeta Consortium. Effect of 5 Genetic Variants Associated with Lung Function on the Risk of COPD, and their Joint Effects on Lung Function. American Journal of Respiratory and Critical Care Medicine 2011, doi:10.1164/rccm.201102-0192OC 31. Freathy RM, Kazeem GR, Morris RW, Johnson PCD, Paternoster LP, Ebrahim S, Hattersley AT, Hill A, Hingorani AD, Holst C, Jefferis BJ, Kring SII, Mooser V, Padmanabhan S, Preisig M, Ring SM, Sattar N, Upton MN, Vollenweider P, Waeber G, Sørensen TIA, Frayling TM, Watt G, Lawlor DA, Whincup PH, Tozzi F, Davey Smith G, Munafò M. Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence BMI. International Journal of Epidemiology 2011; doi:10.1093/ije/dyr077 41. A.E. Taylor, M. N. Sandeep, C. S. Janipalli, C. Giambartolomei, D. M. Evans, M. V. Kranthi Kumar, D. G. Vinay, P. Smitha, V. Gupta, M. Aruna, S. Kinra, R. M. Sullivan, L. Bowen, N. J. Timpson, G. Davey Smith, F. Dudbridge, D. Prabhakaran, Y. Ben-Shlomo, K. S. Reddy, S. Ebrahim, G. R. Chandak. Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier. J Obes. 2011; 2011: 307542. Published online 2011 May 17. doi: 10.1155/2011/307542. |
| Start Year | 2010 |
| Description | GIANT Consortium |
| Organisation | University of Oxford |
| Department | Wellcome Trust Centre for Human Genetics |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Provided Data and Analysis from our Cohort Studies |
| Impact | Contribution to Genome Wide Replication. Papers:- 1) Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genetics 2009;5: e1000508 2)Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics 2008; 41: 25 - 34 3)Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics 2008; 40:768-775, PMID: 18454148. |
| Start Year | 2008 |
| Description | GOYA |
| Organisation | Danish Ministry of Health |
| Department | Danish National Birth Cohort |
| Country | Denmark |
| Sector | Public |
| PI Contribution | Initial formulation of the funding application for this project and then overseeing the collection and analysis of genetic data. Bristol group also largely responsible for the writing and publication of core findings. |
| Collaborator Contribution | The initiation and undertaking of a genetic study within a sample composed of extremes of the BMI distribution. This looks at the genetics of obesity, but leaves behind a valuable genetic resource which is being used in further genetic studies. |
| Impact | Nohr EA, Timpson NJ, Anderson CS, Davey Smith G, Olsen J, Sorensen TI. Severe Obesity in Young Women and Reproductive Health: The Danish National Birth Cohort). PLoS One 4(12) e8444. Doi:10.1371/journal.pone.0008444. Paternoster L, Evans DM, Aagaard Nohr E, Holst C, Gaborieau V, et al. 2011 Genome-Wide Population-Based Association Study of Extremely Overweight Young Adults - The GOYA Study. PLoS ONE 6(9): e24303. doi:10.1371/journal.pone.0024303 |
| Start Year | 2008 |
| Description | HGMD Collaboration |
| Organisation | Cardiff University |
| Department | Cancer and Genetics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A PhD student, Hashem Shihab, who is funded from the MRC doctoral training centre, Bristol Centre for Systems Biomedicine, funded under the 2009 Maths and Stats Capacity Building call (PI Ian Day), is developing hidden Markov model based sequence alignment capitalising on the Superfamily resource run in Bristol by Julian Gough (Computer Sciences), to improve prediction of protein sequence mutations. |
| Collaborator Contribution | HGMD is a unique database resource which we need to access for the development of a predictive software for interpreting protein sequence mutations. |
| Impact | Draft manuscript soon to be submitted: Functional Analysis Through Hidden Markov Models: Predicting The Functional, Molecular & Phenotypic Consequences Of Amino Acid Substitutions. |
| Start Year | 2011 |
| Description | Indian cohort collaborations |
| Organisation | Public Health Foundation of India |
| Department | South Asia Network for Chronic Disease in India (SANCD) |
| Country | India |
| Sector | Public |
| PI Contribution | Intellectual input to establishment of Network Training exchange Prof G Davey Smith spent sabbatical 2009-10 in India, in part working on this Network |
| Collaborator Contribution | Grant Provision for Project undertaking |
| Impact | Network established Sharing of data beginning |
| Start Year | 2009 |
| Description | Investigation of relationship between habitual levels of physical activity |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Access to participants in order to gain new data |
| Impact | Publications |
| Start Year | 2006 |
| Description | KSU Population-based Consanguinity Research Study |
| Organisation | King Saud University |
| Department | Department of Clinical Laboratory Sciences |
| Country | Saudi Arabia |
| Sector | Academic/University |
| PI Contribution | We are guiding and leading the development of the programme (Ian Day has a programme grant full application currently under review with MRC MCMB), contribute the molecular and genetic analysis expertise and drive the writing of papers. Two co-applicants, Muslim Alsaadi, Vice Dean of Medicine, and Khalid Alharbi, represent the KSU arm of this proposal. |
| Collaborator Contribution | Access to human genetic material (offspring of first cousin and similar marriages) not available in the UK. Since these departments are investing staff and student time into development of this research resource, there is indirect financial contribution to our research goals. |
| Impact | First paper accepted subject to revisions: From a single whole exome read to notions of clinical screening: primary ciliary dyskinesia and RSPH9 p.Lys268del in the Arabian Peninsula. Muslim M AlSaadi, Tom R Gaunt, Christopher R Boustred, Philip AI Guthrie, Xuan Liu, Luca Lenzi, Lucille Rainbow, Neil Hall, Khalid K Alharbi and Ian NM Day |
| Start Year | 2010 |
| Description | Liverpool CGR Collaboration |
| Organisation | University of Liverpool |
| Department | Liverpool Centre for Genomic Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are guiding and leading the development of the programme (Ian Day has a programme grant full application currently under review with MRC MCMB), contribute the molecular and genetic analysis expertise and drive the writing of papers. A co-applicant (Neil Hall) represents Liverpool CGR. |
| Collaborator Contribution | The CGR have run pilot whole exome sequencing as part of our development of a population-based consanguinity research study involving multiple international partners. |
| Impact | First paper accepted subject to revisions: From a single whole exome read to notions of clinical screening: primary ciliary dyskinesia and RSPH9 p.Lys268del in the Arabian Peninsula. Muslim M AlSaadi, Tom R Gaunt, Christopher R Boustred, Philip AI Guthrie, Xuan Liu, Luca Lenzi, Lucille Rainbow, Neil Hall, Khalid K Alharbi and Ian NM Day. |
| Start Year | 2010 |
| Description | MAGIC Investigators |
| Organisation | University of Oxford |
| Department | Wellcome Trust Centre for Human Genetics |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Provided Data and Analysis from our Cohort Studies |
| Impact | Several GWAS publications and others planned: 1. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, et al. (200+ authors). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics 2010; 42:105-116 2. Chen W-M, Erdos MR, Jackson AU, Saxena R, Sanna S, Silver KD, Timpson NJ, Hansen T, Orru M, Piras MG, Bonnycastle LL, Willer CJ, Lyssenko V, Shen H, Kuusisto J, Ebrahim S, Sestu N, Duren WL, Spada MC, Stringham HM, Scott LJ, Olla N, Swift AJ, Najjar S, Mitchell HM, Lawlor DA, Davey Smith G, Ben-Shlomo Y, Andersen G, Borch-Johnsen K, Jorgensen T, Saramies J, Valle TT, Buchanan TA, Shildiner AR, Lakatta E, Bergman RN, Uda M, Toumilehto J, Pedersen O, Cao A, Groop L, Mohlke KL, Laakso M, Schlessinger D, Collins FS, Altshuler D, Abescasis GR, Boeknke M, Scuteri A, Wantanabe RM. Variatoions in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. Journal of Clinical Investigation 2008 ;118:2620-2628 3. Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, Voss LD, Jeffrey AN, Metcalf B, Ferrucci L, Corsi AM, Murray A, Melzer D, Knight B, Shields B, Davey Smith G, Hattersley AT, Di Rienzo A, Frayling T. A common haplotype in the glucokinase gene alters fasting glucose and birth weight: association using 20,902 subjects from 6 studies and assessment of natural selection. American Journal of Human Genetics 2006;79:991-1001 |
| Start Year | 2008 |
| Description | Maternal overnutrition and offspring fat mass and vascular function |
| Organisation | University of Bristol |
| Department | MRC Centre for Causal Analyses in Translational Epidemiology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data |
| Impact | Publications |
| Start Year | 2006 |
| Description | Maternal smoking in pregnancy and child psychological problems: disentangling causal & noncausal effects |
| Organisation | Federal University of Pelotas (UFPel) |
| Department | 1982 Pelotas Birth Cohort |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | To compare four different methods for assessing causality to explore whether maternal smoking in pregnancy is related to psychological problems. |
| Impact | Pediatrics paper: PubMed ref: 20587678 |
| Start Year | 2008 |
| Description | Obesity and depression in adolescents (B659) |
| Organisation | University of Bristol |
| Department | School for Policy Studies |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data |
| Collaborator Contribution | Provision of data |
| Impact | publications |
| Start Year | 2008 |
| Description | Pelotas |
| Organisation | Federal University of Pelotas (UFPel) |
| Department | 1982 Pelotas Birth Cohort |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Grants, Study Design, analysis and paper writing. Cross cohort comparisons |
| Collaborator Contribution | Analysis and paper writing |
| Impact | GRANS:- 1)Public health consequences of modifiable maternal exposures: offspring obesity and cognitive health in two cohorts in the UK and Brazil. Wellcome Trust (Sir Henry Wellcome Postdoctoral Fellowship). PAPERS:- 1) Maternal smoking in pregnancy and child psychological problems: disentangling causal and noncausal effects. Pediatrics 2010; doi:10.1542/peds.2009-2754. PMID: 20587678 2) Differentials and income-related inequalities in maternal depression during the first two years after childbirth: birth cohort studies from Brazil and the UK. Clinical Practice and Epidemiology in Mental Health 2009;5, 5-12, PMID:19500361. 3) Early life diarrhea and later blood pressure in a developing country: the 1982 Pelotas (Brazil) birth cohort study. Journal of Epidemiol Community Health 2009; 63:163-165, PMID:18801796. 4)Socioeconomic position and overweight among adolescents: data from birth cohort studies in Brazil and the UK. BMC Public Health 2009;9:105. PMID:19368733 |
| Start Year | 2007 |
| Description | Physical activity and childhood obesity |
| Organisation | University of Bristol |
| Department | School for Policy Studies |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data |
| Impact | Publications |
| Description | Raine Study |
| Organisation | University of Western Australia |
| Department | Obstetrics and Gynaecology |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | As noted above we have had an exchange of Postdoc/PhD students and via this shared knowledge and expertise and obtained grants and papers together |
| Collaborator Contribution | Post doc fellow - Marie-Jo Brion from MRC CAiTE has been working at UWA helping them to establish expertise in Mendelian Randomization studies Two of their PhD students have spent time at MRC CAiTE learning more about statistical analyses for causal mechanisms |
| Impact | GRANTS:- 1)Palmer L(PI), Pennell C, Beilin L, Lye S, Newnham J. Davey Smith G. A genome-wide search for genes underlying the developmental origins of health and disease. 1st January 2009 for 3 years. National Health and Medical Research Council (572613), Aus$989,500: 2009-2011. 2. Adams L (PI), Olynyh J, Beilin L, Pennell C, Oddy W, Mccaskie P, Lawlor DA. Risk factors for the development of NAFLD beyond insulin resistance: genetic, development and environmental influences (66445). Australian National Health and Medical Research Council Aus $641,125: 2010-2013 PAPERS:- 1)The association of C-reactive protein and CRP genotype with coronary heart disease: Findings from five studies with 4,610 cases amongst 18,637 participants. PloS One 2008; 3:e3011, PMID: 18714384. A number of others currently being drafted |
| Start Year | 2007 |
| Description | Ten Towns Heart Health Study |
| Organisation | St George's University of London |
| Department | Division of Population Health Sciences and Education |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We designed the study, were involved in the genotypic analyses, contributed to the statistical analyses and drafted the manuscript. |
| Collaborator Contribution | They have contributed DNA from Ten Towns Heart Health Study participants for SNP genotyping. They also contributed relevant phenotypes such as cotinine and also a large number of smoking phenotypes from questionnaires. They conducted statistical tests and contributed to drafting a paper. |
| Impact | Santiago Rodriguez, Derek G. Cook, Tom R. Gaunt, Claire M. Nightingale, Peter H. Whincup, Ian N. M. Day. 2011. Combined analysis of CHRNA5, CHRNA3 and CYP2A6 in relation to adolescent smoking behaviour. Journal of Psychopharmachology 25(7):915-923. Santiago Rodriguez. 2010. Smoking behaviour: contrasts and combinations of CHRNA5 and CYP2A6 genotype. Collaboration Development Workshop. Beijing, 29-30 March 2010. Oral presentation. |
| Start Year | 2006 |
| Description | The Hertfordshire Cohort Study |
| Organisation | University of Southampton |
| Department | MRC Lifecourse Epidemiology Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We participated in the study designs, contributed genotyping data, helped with the statistical analyses and were involved in manuscript writing. |
| Collaborator Contribution | They made available to us DNA from the Hertfordshire participants for SNP genotyping; also a large number of phenotypes including bone and anthropometric phenotypes, as well as blood biomarkers. |
| Impact | Mirjam A Lips, Holly E Syddall, Tom R Gaunt, Santiago Rodriguez, Ian NM Day, Cyrus Cooper, Elaine M Dennison and the Southampton Genetic Epidemiology Research Group. 2007. Interaction between birth-weight and polymorphism in the Calcium Sensing Receptor gene in determination of adult bone mass: The Hertfordshire Cohort Study. Journal of Rheumatology 34: 769-775. Elaine M. Dennison, Holly E. Syddall, Karen A. Jameson, Avan Aihie Sayer, Tom R. Gaunt, Santiago Rodriguez, Ian N.M. Day, Cyrus Cooper and Mirjam A. Lips, the Hertfordshire Cohort Study Group. 2009. A study of relationships between Single Nucleotide Polymorphisms from the Growth Hormone- Insulin Like Growth Factor axis and bone mass: the Hertfordshire Cohort Study. Journal of Rheumatology 36(7):1520-1526. Lips MA, Syddall HE, Day INM, Gaunt TR, Rodriguez S, Cooper C, Dennison EM. 2006. Evidence for an early life Calcium sensing receptor gene polymorphism interaction in determination of adult bone mass: The Hertfordshire cohort study. Abstract published in Osteoporosis International 17 Suppl. 2: S345. EM Dennison, HE Syddall, INM Day, TR Gaunt, S Rodriguez, M Lips, C Cooper. 2006. Early life-calcium sensing receptor gene polymorphism interaction in determination of adult bone mass: The Hertfordshire Cohort Study. Abstract published in the Journal of Bone and Mineral Research 21: 1156. |
| Start Year | 2006 |
| Description | The functional study of preterm birth |
| Organisation | Peninsula College of Medicine & Dentistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | ALSPAC provided biological samples, in order for new data to be generated. |
| Impact | Publications |
| Start Year | 2008 |
| Description | The longitudinal courses of depressive symptoms from late childhood to early adolescence and the association with socio-demographic and family factors |
| Organisation | University of Bristol |
| Department | School of Social and Community Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data |
| Impact | Publications |
| Start Year | 2007 |
| Description | The origins and outcomes of persisting phonological impairment. |
| Organisation | University of the West of England |
| Department | Department of Health and Social Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data |
| Impact | Publications |
| Description | The prevalence of dizziness and balance problems in childhood |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data |
| Impact | Publications |
| Start Year | 2007 |
| Description | The role of familial adiposity in explaining associations of hypertensive disorder of pregnancy with offspring blood pressure. |
| Organisation | Erasmus University Rotterdam |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Aim is to examine the association of gestational hypertension and pre-eclampsia with offspring blood pressure and to explore the extent to which any associations are explained by familial adiposity. |
| Impact | ALSPAC paper under review; Generation R paper drafted |
| Start Year | 2008 |
| Description | The role of genotype and maternal smoking during pregnancy on offspring smoking initiation |
| Organisation | University of Bristol |
| Department | School of Experimental Psychology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of existing data, Access to participants for new questionnaires to be sent and new samples taken |
| Impact | Publications |
| Start Year | 2007 |
| Description | To assess whether age at onset of puberty is influenced by intrauterine exposure to endocrine disrupting chemicals. |
| Organisation | Centers for Disease Control and Prevention (CDC) |
| Country | United States |
| Sector | Public |
| PI Contribution | Access to study participants via questionnaire |
| Impact | Publications |
| Description | UCL-Bristol-Leicester-QMUL CardioChip consortium |
| Organisation | Queen Mary University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data sharing within consortium. |
| Collaborator Contribution | Data sharing within the consortium.Data sharing within consortium.Data sharing within consortium. |
| Impact | Disciplines: Statistical genetics, Genetic epidemiology, Molecular Genetics, Bioinformatics. Shah S*, Nelson CP*, Gaunt TR* [* equal authorship], van der Harst P, Barnes T, Braund PS, Lawlor DA, Casas JP, Padmanabhan S, Drenos F, Kivimaki M, Talmud PJ, Humphries SE, Whittaker J, Morris RW, Whincup PH, Dominiczak A, Munroe PB, Johnson T, Goodall AH, Cambien F, Diemert P, Hengstenberg C, Ouwehand WH, Felix JF, Glazer NL, Tomaszewski M, Burton PR, Tobin MD, van Veldhuisen DJ, de Boer RA, Navis G, van Gilst WH, Mayosi BM, Thompson JR, Kumari M, Macfarlane PW, Day IN*, Hingorani AD*, Samani NJ*. Four Genetic Loci Influencing Electrocardiographic Indices of Left Ventricular Hypertrophy. Circ Cardiovasc Genet. 2011 Sep 30; [Epub ahead of print] International Consortium for Blood Pressure Genome-Wide Association Studies; [Author 61/839: Gaunt TR] Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-9. Zabaneh D*, Gaunt TR* [*equal authors], Kumari M, Drenos F, Shah S, Berry D, Power C, Hypponen E, Shah T, Palmen J, Pallas J, Talmud PJ, Casas JP, Sofat R, Lowe G, Rumley A, Morris RW, Whincup PH, Rodriguez S, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Kivimaki M, Whittaker J, Hingorani AD, Day IN*, Humphries SE*. Genetic Variants Associated with von Willebrand Factor Levels in Healthy Men and Women Identified Using the HumanCVD BeadChip. Ann Hum Genet. 2011 Apr 28; [Epub ahead of print] Talmud PJ, Cooper JA, Gaunt T, Holmes MV, Shah S, Palmen J, Drenos F, Shah T, Kumari M, Kivimaki M, Whittaker J, Lawlor DA, Day IN, Hingorani AD, Casas JP, Humphries SE. Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies. Diabetologia. 2011 Apr 1; [Epub ahead of print] Smart-Halajko MC, Robciuc MR, Cooper JA, Jauhiainen M, Kumari M, Kivimaki M, Khaw KT, Boekholdt SM, Wareham NJ, Gaunt TR, Day IN, Braund PS, Nelson CP, Hall AS, Samani NJ, Humphries SE, Ehnholm C, Talmud PJ. The Relationship Between Plasma Angiopoietinlike Protein 4 Levels, Angiopoietinlike Protein 4 Genotype, and Coronary Heart Disease Risk. Arterioscler Thromb Vasc Biol. 2010 Sep 9; [Epub ahead of print] Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD; ASCOT investigators; NORDIL investigators; BRIGHT Consortium. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet. 2009 Nov;85(5):628-42. ] |
| Start Year | 2009 |
| Description | UCL-Bristol-Leicester-QMUL CardioChip consortium |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data sharing within consortium. |
| Collaborator Contribution | Data sharing within the consortium.Data sharing within consortium.Data sharing within consortium. |
| Impact | Disciplines: Statistical genetics, Genetic epidemiology, Molecular Genetics, Bioinformatics. Shah S*, Nelson CP*, Gaunt TR* [* equal authorship], van der Harst P, Barnes T, Braund PS, Lawlor DA, Casas JP, Padmanabhan S, Drenos F, Kivimaki M, Talmud PJ, Humphries SE, Whittaker J, Morris RW, Whincup PH, Dominiczak A, Munroe PB, Johnson T, Goodall AH, Cambien F, Diemert P, Hengstenberg C, Ouwehand WH, Felix JF, Glazer NL, Tomaszewski M, Burton PR, Tobin MD, van Veldhuisen DJ, de Boer RA, Navis G, van Gilst WH, Mayosi BM, Thompson JR, Kumari M, Macfarlane PW, Day IN*, Hingorani AD*, Samani NJ*. Four Genetic Loci Influencing Electrocardiographic Indices of Left Ventricular Hypertrophy. Circ Cardiovasc Genet. 2011 Sep 30; [Epub ahead of print] International Consortium for Blood Pressure Genome-Wide Association Studies; [Author 61/839: Gaunt TR] Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-9. Zabaneh D*, Gaunt TR* [*equal authors], Kumari M, Drenos F, Shah S, Berry D, Power C, Hypponen E, Shah T, Palmen J, Pallas J, Talmud PJ, Casas JP, Sofat R, Lowe G, Rumley A, Morris RW, Whincup PH, Rodriguez S, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Kivimaki M, Whittaker J, Hingorani AD, Day IN*, Humphries SE*. Genetic Variants Associated with von Willebrand Factor Levels in Healthy Men and Women Identified Using the HumanCVD BeadChip. Ann Hum Genet. 2011 Apr 28; [Epub ahead of print] Talmud PJ, Cooper JA, Gaunt T, Holmes MV, Shah S, Palmen J, Drenos F, Shah T, Kumari M, Kivimaki M, Whittaker J, Lawlor DA, Day IN, Hingorani AD, Casas JP, Humphries SE. Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies. Diabetologia. 2011 Apr 1; [Epub ahead of print] Smart-Halajko MC, Robciuc MR, Cooper JA, Jauhiainen M, Kumari M, Kivimaki M, Khaw KT, Boekholdt SM, Wareham NJ, Gaunt TR, Day IN, Braund PS, Nelson CP, Hall AS, Samani NJ, Humphries SE, Ehnholm C, Talmud PJ. The Relationship Between Plasma Angiopoietinlike Protein 4 Levels, Angiopoietinlike Protein 4 Genotype, and Coronary Heart Disease Risk. Arterioscler Thromb Vasc Biol. 2010 Sep 9; [Epub ahead of print] Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD; ASCOT investigators; NORDIL investigators; BRIGHT Consortium. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet. 2009 Nov;85(5):628-42. ] |
| Start Year | 2009 |
| Description | UCL-Bristol-Leicester-QMUL CardioChip consortium |
| Organisation | University of Leicester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data sharing within consortium. |
| Collaborator Contribution | Data sharing within the consortium.Data sharing within consortium.Data sharing within consortium. |
| Impact | Disciplines: Statistical genetics, Genetic epidemiology, Molecular Genetics, Bioinformatics. Shah S*, Nelson CP*, Gaunt TR* [* equal authorship], van der Harst P, Barnes T, Braund PS, Lawlor DA, Casas JP, Padmanabhan S, Drenos F, Kivimaki M, Talmud PJ, Humphries SE, Whittaker J, Morris RW, Whincup PH, Dominiczak A, Munroe PB, Johnson T, Goodall AH, Cambien F, Diemert P, Hengstenberg C, Ouwehand WH, Felix JF, Glazer NL, Tomaszewski M, Burton PR, Tobin MD, van Veldhuisen DJ, de Boer RA, Navis G, van Gilst WH, Mayosi BM, Thompson JR, Kumari M, Macfarlane PW, Day IN*, Hingorani AD*, Samani NJ*. Four Genetic Loci Influencing Electrocardiographic Indices of Left Ventricular Hypertrophy. Circ Cardiovasc Genet. 2011 Sep 30; [Epub ahead of print] International Consortium for Blood Pressure Genome-Wide Association Studies; [Author 61/839: Gaunt TR] Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-9. Zabaneh D*, Gaunt TR* [*equal authors], Kumari M, Drenos F, Shah S, Berry D, Power C, Hypponen E, Shah T, Palmen J, Pallas J, Talmud PJ, Casas JP, Sofat R, Lowe G, Rumley A, Morris RW, Whincup PH, Rodriguez S, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Kivimaki M, Whittaker J, Hingorani AD, Day IN*, Humphries SE*. Genetic Variants Associated with von Willebrand Factor Levels in Healthy Men and Women Identified Using the HumanCVD BeadChip. Ann Hum Genet. 2011 Apr 28; [Epub ahead of print] Talmud PJ, Cooper JA, Gaunt T, Holmes MV, Shah S, Palmen J, Drenos F, Shah T, Kumari M, Kivimaki M, Whittaker J, Lawlor DA, Day IN, Hingorani AD, Casas JP, Humphries SE. Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies. Diabetologia. 2011 Apr 1; [Epub ahead of print] Smart-Halajko MC, Robciuc MR, Cooper JA, Jauhiainen M, Kumari M, Kivimaki M, Khaw KT, Boekholdt SM, Wareham NJ, Gaunt TR, Day IN, Braund PS, Nelson CP, Hall AS, Samani NJ, Humphries SE, Ehnholm C, Talmud PJ. The Relationship Between Plasma Angiopoietinlike Protein 4 Levels, Angiopoietinlike Protein 4 Genotype, and Coronary Heart Disease Risk. Arterioscler Thromb Vasc Biol. 2010 Sep 9; [Epub ahead of print] Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD; ASCOT investigators; NORDIL investigators; BRIGHT Consortium. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet. 2009 Nov;85(5):628-42. ] |
| Start Year | 2009 |
| Description | UCLEB |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data sharing within consortium. |
| Collaborator Contribution | Data sharing within consortium.Data sharing within consortium. |
| Impact | Disciplines: Statistical genetics, Genetic epidemiology, Molecular Genetics, Bioinformatics. BHF programme grant funding (PI Aroon Hingorani, UCL) |
| Start Year | 2011 |
| Description | UCLEB |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data sharing within consortium. |
| Collaborator Contribution | Data sharing within consortium.Data sharing within consortium. |
| Impact | Disciplines: Statistical genetics, Genetic epidemiology, Molecular Genetics, Bioinformatics. BHF programme grant funding (PI Aroon Hingorani, UCL) |
| Start Year | 2011 |
| Description | UK10K |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Co-applicants on successful grant application to Wellcome Trust. Will work with Sanger and other cohorts to establish sequence data (including in ALSPAC) and undertake appropriate analyses with these. |
| Collaborator Contribution | Grant Provision for Project undertaking |
| Impact | Successful grant Data collection will start in 2011 for this collaboration |
| Start Year | 2010 |
| Description | Wellcome Trust Case Control Consortium |
| Organisation | Peninsula College of Medicine & Dentistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided and Analysis from our cohort studies |
| Impact | Contribution to Genome Wide Replication, Papers:- Genome-wide association analysis identifies 20 loci that influence adult height.Nat Genet. 2008 May;40(5):575-83. Epub 2008 Apr 6 Comment in:- Nat Genet. 2008 May;40(5):489-90. PMID: 18391952 , A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894, PMID:17434869, A common variant of HMGA2 is associated with adult and childhood height in the general population. Nature genetics 2007; 39:1245-1250, PMID: 17767157, Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected, given its effect on BMI. Diabetes 2008;57: 1419-1426, PMID: 18346983, A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. Human Molecular Genetics 2009;18:2922-2927. PMID:19429911, Type 2 Diabetes Risk Alleles are Associated with Reduced Size at Birth. Diabetes 2009; 58:1428-1433, PMID: 19228808, Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight, Nature Genetics 2010,42:430-435. PMID:20372150, |
| Start Year | 2008 |
| Description | pQCT |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Analysis of genome-wide association data. |
| Collaborator Contribution | Provision of genome-wide association summary statistics for meta-analysis. |
| Impact | PMID: 21124946 ; PMID: 20534768 |
| Start Year | 2010 |
| Description | A seminar by a member of Science Media Centre was organised |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Dr Nicolas Timpson organised a seminar for the department by Dr Helen Jamieson of Science Media Centre whose talk was "Science and the Media: Experience from the front line" This generated interest to members of the department, and other parts of the faculty about scientists engaging with the public. |
| Year(s) Of Engagement Activity | 2009 |
| Description | 8th Mackenzie Lecture University of Dundee |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | Invited Speaker - "The Limits of Personalised Medicine: Epidemiological Reflections" Increased interest in Mendelian Randomization |
| Year(s) Of Engagement Activity | 2013 |
| Description | Article for Department of Education |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Suzi Gage, the PhD student who wrote the article, was invited to give a seminar on her paper at the Department for Education. This was broadcast across four of their sites. None so far. |
| Year(s) Of Engagement Activity | 2010 |
| Description | Article for FutureMorph website |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | FutureMorph is a website for teenagers about the exciting possibilities of studying STEM subjects. The article will have helped generate conversation and debate on this subject. None so far. |
| Year(s) Of Engagement Activity | 2011 |
| Description | BBC Radio 4 interview for the programme, 'Sick Society' , as part of the 'Analysis' series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The interview was broadcast as part of an established series on Radio 4 and would have reached a large national audience. The programme is likely to have provoked thought and stimulated discussion amongst the listeners and to have given rise to feedback. |
| Year(s) Of Engagement Activity | 2012 |
| Description | CIHR STAGE |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | CIHR STAGE International Speaker Seminar Series. The Hospital for Sick Children, Toronto Canada, 3rd May 2013 - "How Can Genetic Epidemiology Help Identify Causes of Disease?" Informed discussion |
| Year(s) Of Engagement Activity | 2013 |
| Description | Conference on diet and coronary heart disease Oslo |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Conference on diet and coronary heart disease. Hotel Bristol, Oslo, Norway 24-25 January 2013 - 'Causation and causal inference in epidemiology' Raised discussion on the relationship between epidemiology, diet and coronary heart disease |
| Year(s) Of Engagement Activity | 2013 |
| Description | Consultant to the Science Musem - update on Epidemiology section of the Health Matters modern medicine gallery |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor George Davey Smith to be Consultant to the Science Museum for described activity. Unknown |
| Year(s) Of Engagement Activity | 2008 |
| Description | Doc/Fest film festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The member of staff was able to discuss science with members of the public. A number of people who do not necessarily think about science will have been reached though their attendance at this Festival. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Helped at MRC stand at the Cheltenham Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Philip Guthrie and Ms Marie Elmhirst helped at the MRC stand in the Discover Zone over 5 days at the Cheltenham Science Festival in 2008. Unknown |
| Year(s) Of Engagement Activity | 2008 |
| Description | Helping with MRC stall at one day Oxford Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Many older and primary-school age children and their parents spent time at the stall; the children were able to paint pictures of cells, model different types of cell in clay and have a model of the human body dismantled and explained to them; their parents were able to ask questions about science and the work of the MRC. Students of GCSE age asked specific questions with a view to choosing science subjects to study at university. |
| Year(s) Of Engagement Activity | 2010 |
| Description | I'm a Scientist, Get Me Out of Here |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Suzi Gage, a PhD student, won the Brain Zone; her prize was £500 to spend on science communication. She received some extra funding from the MRC and is using that and her prize money to make a series of podcasts aimed at teenagers, explaining current evidence on the effects of taking recreational drugs. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Ian Day gave a lecture to Bristol Enterprise Network |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation titled, "The potential of genetics to enable personalization of healthcare" for an evening themed, "The Personalised Health Care Revolution". Unknown |
| Year(s) Of Engagement Activity | 2009 |
| Description | Integrative Comments |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | University of Sao Paulo Conference, Sao Paulo Brazil, 14-15 March 2013 Informed debate |
| Year(s) Of Engagement Activity | 2013 |
| Description | Interview as part of an article for 'New Scientist' magazine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Too early to say, but likely to be discussed on 'New Scientist' letters page and website. Too early to say, but likely to be feedback through 'New Scientist' letters page and website. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Interview for BBC Radio 4's programme, 'Science: From Cradle to Grave' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor George Davey Smith was able to widen listeners' understanding of longitudinal studies. None so far. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Interview for BBC Radio Bristol on ageing and genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor Ian Day was interviewed by Dr Phil Hammond on Saturday Surgery and was able to further the local public's understanding of this area of science. None so far. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Interview inputs about human genetics to a film documentary |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Film being made by Dan Lewis (3rd year UWE Media and Cultural Studies on the subject of 'Science Ideology and Society' Unknown |
| Year(s) Of Engagement Activity | 2009 |
| Description | Lecture to 6th form pupils at Redland School |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The lecture generated discussion and further debate. Invitations for further involvement with the school. |
| Year(s) Of Engagement Activity | 2010 |
| Description | MRC CAiTE staff and PhD Students Volunteered on the MRC Stand at the Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Ms Bhavna Mistry, Ms Anya Burton, Mr Chris Boustred, Mr Dylan Williams volunteered at the MRC Stand on various days throughout the Cheltenham Science Festival June 2010 Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | MRC CAiTE staff and PhD Students Volunteered on the MRC Stand at the Oxfordshire Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Dr Philip Guthrie and Mr Dylan Williams (PhD student) volunteered on the MRC Stand at the Oxfordshire Science Festival Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | MRC Population Cohort Strategy Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | Portfolio Balance. MRC Population Cohort Strategy Workshop 6th March 2013 Informed discussion |
| Year(s) Of Engagement Activity | 2013 |
| Description | MRC centenary showcase at M Shed Bristol |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor Debbie Lawlor gave a presentation to the entire audience (200) about ALSPAC, and two study participants led two round table sessions (each with 10-12 people) about their role in ALSPAC's teenage advisory panel. Event generated lots of stimulating discussion and debate. |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.bristol.ac.uk/news/2013/9471.html and http://www.centenary.mrc.ac.uk/open_days/mrcunivers... |
| Description | MRC stall, Cheltenham Science Festival, manned by Chris Boustred and Dylan Williams, PhD students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Schoolchildren of various ages and members of the general public learned about neuroscience through displays, demonstrations and hands-on activities. Students of GCSE age asked specific questions with a view to choosing science subjects to study at university. |
| Year(s) Of Engagement Activity | 2010 |
| Description | Manning MRC stand at Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The stand and Festival attracted a large audience from across the region. School-age children attending with their parents will have been stimulated to study science subjects at school and beyond. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Media coverage of research paper in Circulation, an American journal |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A press release was sent to specific contacts in the national press, including the science reporter on the Daily Mail; the latter printed a piece about the research on June 2nd. Abigail Fraser, the co-author of the paper, participated in a local radio programme in Bristol. Unknown |
| Year(s) Of Engagement Activity | 2010 |
| Description | OMICS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | OMICS Omics Conference,Bristol 19th June 2013 Discussion of the relationship between omics and nutrition |
| Year(s) Of Engagement Activity | 2013 |
| Description | PHD student became science correspondent for the University of Bristol's newspaper |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Current questions in science research are being brought to the attention of all staff and students at the University of Bristol by Suzi Gage's articles. None so far. |
| Year(s) Of Engagement Activity | 2011 |
| Description | PHRI Rounds Hamilton Canada |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | PHRI Rounds. Population Health Research Institute, Hamilton, Canada - 7th May 2013. "Mendelian randomization in cardiovascular disease: what does the future hold?" Informed discussion |
| Year(s) Of Engagement Activity | 2013 |
| Description | Participation in a Science Cafe at the Tobacco Factory in Bristol |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Laura Howe was able to discuss careers in science research with the attendees and to explain her research using the ALSPAC data. None so far. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Population Sciences Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Population Sciences Lecture - Population Health Research Institute, Hamilton, Canada, 7 May 2013. "The limits of personalized medicine: epidemiological reflections" Informed discussion |
| Year(s) Of Engagement Activity | 2013 |
| Description | Presentations at the Public Health Grand Round |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Oral Presentations by Professor Debbie Lawlor and Dr Nicolas Timpson Unknown |
| Year(s) Of Engagement Activity | 2008 |
| Description | Public Debate on the Future of Genomics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor George Davey Smith took part in this public discussion event held at 'Explore @ Bristol' The exhibition called "Inside DNA: A Genomic Revolution" is the UK's first major touring exhibition on genomics. Unknown |
| Year(s) Of Engagement Activity | 2007 |
| Description | Queensland Institute of Medical Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | External Seminar Series, Queensland Institute of Medical Research, Australia - 9th April 2013 - Mendelian Randomization: the next ten years Informed discussion |
| Year(s) Of Engagement Activity | 2013 |
| Description | SPark in the Science City Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Ms Marie Elmhirst attended the SPark in the Science City conference on 29th April 2008. SPark is the new £300 million science park for Bristol and Bath. Unknown |
| Year(s) Of Engagement Activity | 2008 |
| Description | School student was hosted at MRC CAiTE over a summer holiday period |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Professor Ian Day hosted a school student from Wessex Setpoint during summer 2008, and attended and made input to the Wessex Setpoint presentation day event in Bath in September 2008. The student learned about genocopy/phenocopy effects and applied this to analysis of pigmentation effects in age-related macular degeneration and to effects of smoking or nicotine across a wide range of diseases. This was under a Nuffield Bursary. In March 2009 the student was to present at the national UK Young scientists' and Engineers' Fair 2009. This Centre to a bright and ambitious national cadre of school students. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Science Alive 2008! |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Demonstrations and activities/poster displays about the University's research held in the public shopping area of Broadmead in Bristol. This is to allow school children and shoppers to explore the various activities. Unknown |
| Year(s) Of Engagement Activity | 2008 |
| Description | TEDx Bristol 2013 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | TEDx are making a film about Dr Rebecca Peason's work on depressogenic cognitive style in the cohort which will be shown at TEDx as part of the 'Psychology of Failure' theme in which George Davey Smith is a key participant. The resulting film will be available on the TEDx website and ALSPAC's YouTube channel. The event is taking place on 11 November so too earlier to report on impact. |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://tedxbristol.com/ |
| Description | Talk at Summer School for years 11 to 12 students |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Professor Debbie Lawlor gave a talk entitled "Detective Work in Medical Research". Unknown |
| Year(s) Of Engagement Activity | 2008 |
| Description | Techniquest lecture, Cardiff |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The lecture contributed to a public discussion about whether weight is destined by genes. Will have led to further debate. |
| Year(s) Of Engagement Activity | 2011 |
| Description | The Huxley Debate |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | Participant in the Huxley Debate on The Science of Epigenetics Enlightening the audience in the science of epigenetics |
| Year(s) Of Engagement Activity | 2013 |
| Description | The Legacy of John Snow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | University of Sao Paulo Conference, Brazil - Cholera Vaccination 1894: the first controlled medical trial. The legacy of John Snow: epidemiology yesterday, today and tomorrow Informed discussion |
| Year(s) Of Engagement Activity | 2013 |
| Description | Twilight talk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | 160 members of the public attended. The evening was a series of round table talks with members of the public selecting 3 of these from 'lay abstracts' that were submitted by the academics. After 40 minutes a bell sounded and the member of the public moved on to their next discussion topic. The academic was there to answer questions and facilitate discussion in a pre-specified area. Prof DA Lawlor supported a table discussion on the role of reproductive health in healthy ageing. Feedback was excellent with 90% reporting that they had enjoyed and learnt from the evening and 85% saying that they would definitely attend another similar event. |
| Year(s) Of Engagement Activity | 2006,2010 |
| Description | Two Page Spread in Bristol Evening Post |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A two page spread in the Bristol Evening Post of 4th June 2008 on the work of Professor Debbie Lawlor on the two year study to understand the causes, development and prevention of obesity, diabetes and heart disease in women. Unknown |
| Year(s) Of Engagement Activity | 2008 |