A pragmatic randomised controlled trial of screening for osteoporosis in older women

Lead Research Organisation: University of East Anglia
Department Name: Norwich Medical School

Abstract

Osteoporosis is a common disease affecting around 20% of women aged over 50 years. The condition causes a ?thinning? of the bones making a sufferer prone to fractures. These fractures, particularly hip fractures, can lead to disability, a loss of independent living and even death. Current treatment for osteoporosis can reduce the risk of fracture by around 35% to 50%. However, predicting which women are at high risk of fracture and therefore would most likely benefit from treatment has so far not been conducted in a comprehensive and systematic manner. This study sets out to trial a method of screening all women aged between 70 and 85 for risk of fracture. Women in that age group recruited to the study will either be screened or managed as usual. Those screened and considered at high risk will be offered treatment by their GPs. All women will be followed for 5 years and, at the end of that period, a comparison of the fractures in the screened group will be made with those in the non-screened group. It is hoped that screening will reduce the number of fractures by around 20%.

Technical Summary

The proposed randomised controlled trial aims to evaluate the effectiveness and cost-effectiveness of a community based screening program for osteoporosis in women aged 70 to 85. Those women randomised to the screening arm of the trial will provide information on clinical risk factors followed by bone mineral density (BMD) measurements where this information would be deemed useful. Based upon this information, a 10-year absolute risk for fracture will be calculated. This information will be given to study subjects? GPs with an indication of whether this risk exceeds a pre-determined treatment threshold or not. Those women in the control arm will be treated ?as usual?. The primary effiacy outcome, to be ascertained from hospital records will be fracture at any site. The follow up period will be 5 years and a sample size of 11 500 women will be sufficient to provided 90% power to detect a 18% relative reduction in fractures.

Publications

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Hiligsmann M (2019) Patients' preferences for osteoarthritis treatment: the value of stated-preference studies. in Aging clinical and experimental research

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Mitchell Natasha (2011) A controlled trial of envelope colour for increasing response rates in older women in AGING CLINICAL AND EXPERIMENTAL RESEARCH

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Moon RJ (2019) Vitamin D supplementation: are multivitamins sufficient? in Archives of disease in childhood

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Sletner L (2018) Childhood Fat and Lean Mass: Differing Relations to Vascular Structure and Function at Age 8 to 9 Years in Arteriosclerosis, thrombosis, and vascular biology

 
Description Efficacy and Mechanisms Evaluation
Amount £180,384 (GBP)
Funding ID G0601019 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 06/2015
 
Description NIHR Research for Patient Benefit
Amount £152,839 (GBP)
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start 01/2008 
End 06/2013
 
Title Fracture data collection methods 
Description The SCOOP RCT has used an approach to data collection for fracture outcome that is being duplicated in at least one other RCT. It makes use of self-report and readily available data through the NHS. 
Type Of Material Improvements to research infrastructure 
Year Produced 2011 
Provided To Others? Yes  
Impact Little at present. Now being used by another trial and, informally, suggested as the main method for the primary outcome data collection for a second. 
 
Title SCOOP cohort database 
Description The SCOOP trial has provide a database of over 12000 older women followed up for more than 5 years. These have been recruited from the general community (rather than disease or condition specific) and have comprehensive data on osteoporosis medications and fractures, amongst other things. This should prove a good asset for future work. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact None to date but this database will be of use to other groups once the trial and associated papers are complete. Data are now being released to the wider research team to pursue secondary research questions. In addition, an application has been submitted to the HTA for further funding to keep data collection going for a further five years. If successful this will be a very valuable database. 
 
Description "Meet the Expert Workshop" 2-4 December 2018, Kate Ward 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Kate Ward led a "Meet the Expert Workshop" at the 2018 National Osteoporosis Society Annual Conference which took place in Birmingham from 2nd to 4th December 2018
Year(s) Of Engagement Activity 2018
 
Description 2018 National Osteoporosis Society Annual Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A number of MRC LEU investigators attended the 2018 National Osteoporosis Society Annual Conference. Young Investigator Awards were received by Beth Curtis, Millie Parsons, Michael Clynes and Nick Fuggle. Kate Ward led a Meet the Expert Workshop and Professors Cyrus Cooper and Nick Harvey also gave major invited plenary presentations. Nick and Kate are also members of the Conference Organising Committee. There was a lot of social media activity surrounding this event.
Year(s) Of Engagement Activity 2018
 
Description 28th Seah Cheng Memorial Lecture, Singapore, 15-18th September 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cyrus was invited to give the keynote address at the Academy of Medicine, Singapore on 'Osteoarthritis - from paediatric days to geriatric times'.
Year(s) Of Engagement Activity 2018
 
Description Appointment to non-executive director of hospital trust 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact The University of Southampton Medicine News Page reported that Professor Cyrus Cooper has been appointed as non-executive director of hospital trust.
Year(s) Of Engagement Activity 2018
 
Description Arthritis Research Sub-Committee in Chesterfield on 23rd May 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Arthritis research sub-committee meeting in Chesterfield on 23rd May 2018
Year(s) Of Engagement Activity 2018
 
Description Article appeared in Healio with quotes by Nick Harvey regarding findings in his paper which was published in July 2018 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact An article appeared in healio with quotes by Nick Harvey regarding the findings in his paper which was published in July 2018
Year(s) Of Engagement Activity 2018
 
Description Article attracted great deal of media attention 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Hill WD, Marioni RE, Maghzian O, Ritchie SJ, Hagenaars SP, McIntosh AM, Gale CR, Davies GA combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence. Molecular psychiatry 2018/01/11 doi 10.1038/s41380-017-0001-5.
This article attracted a great deal of media attention - as well as appearing in a number of newspapers it was tweeted by 467 people, was on 7 facebook pages, mentioned in 3 Google+ posts, picked up by 14 news outlets, 4 Reddit and 2 videos, plus 54 readers on Mendeley.
Year(s) Of Engagement Activity 2018
 
Description Article entitled "higher inflammation in older age is linked to lower bone density" appeared in the University of Southampton medicine news and in the medicalexpress website 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Article entitled "higher inflammation in older age is linked to lower bone density" appeared in the University of Southampton medicine news and in the medicalexpress website
Year(s) Of Engagement Activity 2018
 
Description BBC Interview in Singapore for International News 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Cyrus Cooper gave an interview on BBC World News addressing recent advances in the risk assessment and treatment of osteoporosis.
Year(s) Of Engagement Activity 2018
 
Description Blog written by Cyrus Cooper and Nick Harvey which appeared in the Medically Spekaing section of the Unviersity of Southampton website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Cyrus Cooper and Nick Harvey wrote a blog which appeared in the "Medically Speaking" section of the University of Southampton website. Their blog was about the National Osteoporosis Society Annual Osteoporosis Conference, at which four members of the MRC LEU, Beth Curtis, Millie Parsons, Nick Fuggle and Michael Clynes all received young investigator awards.
Year(s) Of Engagement Activity 2018
 
Description Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: findings from the UK Biobank Cohort - press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Press release created a lot of media interest for this paper.
Year(s) Of Engagement Activity 2018
 
Description Cyrus Cooper and Keith Godfrey - Clarivate Highly Cited Researchers 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Both Cyrus Cooper and Keith Godfrey received congratulations for being among 2018s highly cited researchers. They were included in the Clarivate Analytics listings and also mentioned on the University of Southampton website.
Year(s) Of Engagement Activity 2018
 
Description Cyrus Cooper was interviewed for an article that was published in the Telegraph as a result of the paper that was published in the BMJ on Vitamin D. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Cyrus Cooper was interviewed for an article that was published in the Telegraph as a result of the paper that was published in the BMJ on Vitamin D. His comments included: Cyrus Cooper, Professor of Rheumatology at the University of Southampton and President of the International Osteoporosis Foundation who contributed to the study said that bone density was probably some two to three times better at predicting someone's risk of getting osteoporosis than their level of Vitamin D level. "I don't think this paper debunks the idea that Vitamin D is useful", he said. "It's just that it is a small determinant. You'd do some good if you make sure that your Vitamin D levels are okay." Commenting on the current UK advice for management and prevention of osteoporosis he said: "The current guidelines are appropriate however a bone density evaluation needs to be done as part of fracture risk screening".
Year(s) Of Engagement Activity 2018
 
Description Fake Food Event Feedback 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Sian Robinson was one of the six panellists at the Fake Food event which took place at Lecture Theatre 1, SAB, Southampton General Hospital. The panel were asked questions by groups of local sixth formers who had been invited to the event.
Year(s) Of Engagement Activity 2018
 
Description Findings from the paper 'Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death' appeared in the Hippocratic Post and other media 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Findings from the paper 'Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: Findings from the UK biobank cohort. J Bone Miner Res. 2018 May;33(5):803-811. doi: 10.1002/jbmr.3375, epub 2018 Feb 8'. appeared in the Hippocratic Post, on other websites, on 3 facebook pages, 34 tweets, and 1 blog.
Year(s) Of Engagement Activity 2018
 
Description Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial - press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact https://www.southampton.ac.uk/medicine/news/2018/11/vitamin-d-baby-genes.page; https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbmr.3603
Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial. Journal of Bone and Mineral Research. 2018 doi.10.1002/jbmr.3603
Curtis EM, Krstic N, Cook E, D'Angelo S, Crozier SR, Moon RJ, Murray R, Garratt Em, Costello P, Cleal J et al (inc Godfrey K, Cooper C and Harvey N).
Year(s) Of Engagement Activity 2018
 
Description Hertfordshire Public Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact Approximately 300 HLS participants and their families attended an open day, which led to discussion, questions and interest in future research studies.
Year(s) Of Engagement Activity 2018
 
Description High Commissioner, Singapore 17-18th September 2018 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact During the visit he was invited to a discussion on UK-Singapore research collaborations at Eden Hall, the residence of His Excellency Mr Scott Wightman, UK High Commissioner to Singapore.
Year(s) Of Engagement Activity 2018
 
Description Lister Research Prize 2017 in London on 22nd May 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation of the Lister Research Prize 2017
Year(s) Of Engagement Activity 2018
 
Description MRC Festival of Medical Research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact On 23rd June 2018 a number of MRC LEU staff (Prof Cyrus Cooper, Prof Hazel Inskip, Prof Elaine Dennison, Prof Sian Robinson, Gregorio Bevilcqua, Leo Westbury, Barbara Fariborz, Martin Stevens, Tina Horsfall, Holly Syddall, Kate Ward, Shirley Simmonds, Millie Parsons, Michael Clines, Vanessa Cox, Clare Harris, Harnish Patel and Ilsa Bloom) travelled to Hertfordshire for the MRC Festival of Medical Research where they held the Hertfordshire Cohort Study Open Day at Harpenden Public Halls. There were two sessions, one in the morning and the other in the afternoon. Many of the participants of the Hertfordshire study, their children and grandchildren attended the event which included a talk by Cyrus Cooper and hands on activities - refreshments were provided. An article appeared in MRC Life and another article about the open day was sent to Charlotte Campbell at UCL to be included in the CLOSER newsletter.
Year(s) Of Engagement Activity 2018
 
Description MRC Grant for £134K 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cyrus Cooper and Nick Harvey were successful in securing an MRC Grant to the value of £134k which will fund a new dual energy x-ray absorptiometry (DXA) instrument and Mechanograph technology.
Year(s) Of Engagement Activity 2018
 
Description Media attention from release of paper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact 'The impact of menopausal hormone therapy (MHT) on cardiac structure and function: insights from the UK biobank imaging enhancement study'. PLoS One 2018, March 8th.
Within a few days of being published this paper was within the top 5% of articles for this phenomenal almetrics score. The attention score showed 75 news outlets, 1 blog, 15 tweeters from around the world. Many newspapers picked up the story, including the Sun, The Daily Mirror, The Daily Mail, The Daily Star. It also appeared on a number of websites: Science Daily; Mayo Clinic, Queen Mary University of London, The Citizen and Deccan Chronicle, as well as those of the newspapers.
Year(s) Of Engagement Activity 2018
 
Description NEWS: Dr Christopher Bell led the largest sequencing based analysis to date of genetically driven epigenetic variation in the human genome. 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact NEWS: Dr Christopher Bell (MRC-LEU & IDS), in collaboration with King's College London and BGI Shenzhen, has led the largest sequencing-based analysis to date of genetically driven epigenetic variation in the human genome. This work, published in Nature Communications, has implications for the functional dissection of common disease associated regions, as well as the interpretation of DNA methylation population studies.
Year(s) Of Engagement Activity 2018
 
Description Osteoporosis Dorset Meeting (invited speaker), December 4th 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact This was a presentation of the main SCOOP results on invitation to the annual 'Osteoporosis Dorset' meeting. The group is a regional charity with a mixed audience of practitioner, patients and charity supporters, numbering around 100. A number of questions and discussions arose in light of the talk.
Year(s) Of Engagement Activity 2018
URL http://www.osteodorset.org.uk/
 
Description Osteoporosis Information Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Around 100 people for the local area with an interest in osteoporosis. Organised by the local trust and local NOS.

Impossible to say.
Year(s) Of Engagement Activity 2013
 
Description Osteoporosis Review Editorial 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Entry for PURE: Editorial work: Elaine wrote an editorial for Osteoporosis Review. The Journal of the National Osteoporosis Society.
Year(s) Of Engagement Activity 2018
 
Description Paget's Information Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact Approximately 50 patients attended for an information afternoon, with Professor Elaine Dennison, which sparked questions and discussion with patients reporting better knowledge of their condition.
Year(s) Of Engagement Activity 2018
 
Description Paper appeared online in December 2017 after its press release, further media attention on 1.2.18 in MIMS 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This paper first appeared online in December 2017 after its press release. However, in 2018 it received further media attention on 1.2.18 in MIMS with an article entitled GP-led screening reduces hip fracture risk in older women and on 2.3.18 in Medical Health News net an article entitled FRAX: a nuanced tool for predicting fracture risk. There were also 149 tweets and 28 retweets.
Year(s) Of Engagement Activity 2018
 
Description Paper received a great deal of media interest, appearing on a number of websites 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact McLachlan JJ, Gale CR.
The effects of psychological distress and its interaction with socioeconomic position on risk of developing four chronic diseases. Journal of Psychosomatic Research. 2018; 109: 79-85.
This paper received a great deal of media interest, appearing on a number of websites, including: University of Southampton, the Daily Mail, University Hospitals Southampton, the Sun, ITV News, Medical News Today, reachmd.com, managed health care executive.com, anxious minds, the star and archyworldys. An article also appeared in the Daily Echo.
Year(s) Of Engagement Activity 2018
 
Description Podcast on Sarcopenia 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Health practitioners and pharmaceutical industry professionals listened to a podcast leading to discussion and follow up emails
Year(s) Of Engagement Activity 2018
 
Description Presentations at St Swithans School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Approximately 10 sixth form students attended a talk about academic medicine which resulted in questions and discussion with follow up email correspondence, hosted by Professor Elaine Dennison on 3rd May 2018.
Year(s) Of Engagement Activity 2018
 
Description Press release followed by online publicity 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Gilbert T, Neuburger J, Kraindler J, Keeble E, Smith P, Arti C, Arora S, Street A, Parker S, Roberts HC, Bardsley M, Conroy S. Development and validation of a hospital frailty risk score focusing on older people in acute care settings using electronic hospital records: an observational study. Lancet 2018;391:1775-82.
Year(s) Of Engagement Activity 2018
 
Description Press release resulted in some media interest 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Pinedo-Villanueva R, Westbury LD, Syddall HE, Sanchez-Santos MT, Dennison EM, Robinson SM, Cooper C.
Health care costs associated with muscle weakness: a UK population based estimate. Calcified Tissue International. 2018; https://doi.org/10.1007/s00223-018-0478-1
A press release entitled "muscle weakness costs the UK £2.5 billion" resulted in some media attention, mostly on social media but also online and in the local press.
Year(s) Of Engagement Activity 2018
 
Description Press release resulting in online media attention 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact An atlas of genetic influences on osteoporosis in humans and mice. Nature Genetics https://doi.org/10. 1038/s41588-108-0302-x; https://www.uq.edu.au/news/article/2019/01/gene-map-offers-osteoporosis-hope

The paper was published on 31.12.18 and received a large amount of media attention. It is considered a ground breaking new study led by researchers from the Lady Davis Institute at the Jewish General Hospital. It has compiled an atlas of genetic factors associated with estimated bone mineral density.
Year(s) Of Engagement Activity 2018
 
Description Professor Cyrus Cooper, Director of the MRC Lifecourse Epidemiology Unit interviewed by Wessex Monthly Magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Professor Cyrus Cooper, Director of the MRC Lifecourse Epidemiology Unit was interviewed by the publication, Wessex Monthly Magazine, and explains how his research has translated into improvements in patient care and how continued exploration could lead to further discoveries in the next 70 years of the NHS. This was mentioned in the University e-news.
Year(s) Of Engagement Activity 2018
 
Description Social inequality and fractures - secular trends in the Danish population: a case control study. Osteoporosis International 2018;29:2243-50 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The findings of this paper received quite a bit of media attention with a number of comments being added to the online articles.
Year(s) Of Engagement Activity 2018
 
Description Southampton General Hospital Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We offered two activities suitable for adults and children - measuring grip strength and making an x-ray of the hand with clay. The open day was extremely well attended and we had great interest in both the activities and also our research ongoing within the Unit, particularly among undergraduate students and their parents. People reported changes in their views and opinions and asked for further information.
Year(s) Of Engagement Activity 2018
 
Description The MRC Festival Zone, 4-29th June 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact "I'm a Scientist get me out of here", part of the MRC Festival Zone from 4th-29th June 2018 with over 1,300 students and their teachers taking part. This involved a 30 minutes live webchat where pupils were able to ask any questions they wanted and there was also the ability for students to ask further questions via the ASK function of the website. During the 4 week event Millie took part in 30 of the 30 minute webchats (15 hours in total) and then responded to a further 58 questions. The intention of the event is to encourage children to consider the importance of science and demonstrate the career options open to them in science.
Year(s) Of Engagement Activity 2018
 
Description The Opening of Southampton Paget's Centre of Excellence 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact On Thursday 31st May 2018 the MRC Lifecourse Epidemiology Unit in Southampton hosted an event to celebrate being awarded Centre of Excellence status for the Paget's Association. There was a press release and the event was recorded online, in social media and had a two page spread in Paget's News (August 2018).
Year(s) Of Engagement Activity 2018
 
Description Twitter Tweets for Recurrent back pain during working life and exit from paid employment: a 28 year follow up of the Whitehall II study. 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Lallukka T, Many M, Cooper C, Fleischmann M, Kouvonen A, Walker-Bone KE, Head JA, Halonen JI. Recurrent back pain during working life and exit from paid employment: a 28 year follow up of the Whitehall II study. Occup Environ Med. 2018; 75: 786-91.
This paper received a number of tweets putting it in the top 25% of all research outputs scored by Altmetric.
Year(s) Of Engagement Activity 2018
 
Description Wearing white for World Cancer Day 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Media (as a channel to the public)
Results and Impact 16 members of staff took part in the University of Southampton's "Wear White for World Cancer Day" with more making donations. Altogether the MRC LEU donated £41.
Year(s) Of Engagement Activity 2018
 
Description Website and enews 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact McLachlan KJJ, Gale CR. The effects of pshychological distress and its interaction with socioeconomic position on risk of developing four chronic diseases. Journal of Psychosomatic Research. 2018; 109:79-85.
The findings of the paper co-authored by Catherine Gale received a lot of media attention appearing on a number of websites.
Year(s) Of Engagement Activity 2018
 
Description Wellcome Trust Award 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact £1.6 m Wellcome Trust award and using data from the UK Biobank, is intended to reduce the impact of these common musculoskeletal disorders by providing a basis for improved means of disease prediction, prevention and treatment. The project, led by Jon Tobias, Professor of Rheumatology at Bristol Medical School, will involve a collaboration between researchers from the University of Southampton, as well as Bristol, Manchester, Aberdeen, Cardiff and Queensland Universities.

News of this award attracted media attention and was on a number of websites.
Year(s) Of Engagement Activity 2018