University of Newcastle Centre for Brain Ageing & Vitality supported by BBSRC, EPSRC, ESRC and MRC

Lead Research Organisation: Newcastle University
Department Name: Research and Enterprise Services

Abstract

In the UK there is a major change in the age of the population - we are all living much longer. Unfortunately old age is often associated with poor health. We still do not understand why this. What we want to understand is why the brain ages and how exercise and diet are helpful to healthy ageing of the brain and body.

As we get older the thing we often fear is getting dementia, Parkinson’s disease or other age related diseases. Whilst these diseases can also strike relatively young people, the majority of people with these diseases are elderly. What is it about our brains as they age that means that we are at much greater risk of these diseases?

Lots of different work has shown that exercise is good for us, but this is particularly true the older we get. It is really important to know how much exercise we should take to keep our muscles strong and make sure we keep mobile as we get older. There are similar findings with different diets, some seem to be much healthier than others – but what are the most important ingredients?

The new MRC Centre for Brain Ageing and Vitality in Newcastle is going to try and answer these questions about our ageing brain and our lifestyle.

Technical Summary

The MRC Centre for Brain Ageing and Vitality will develop innovative, world-class research and training related to brain ageing and frailty. The MRC Centre will be a partnership with Newcastle University and will be based in new purpose built laboratory space. The strategic added value from the MRC Centre for Brain Ageing and Vitality will come from targeted expansion of the interface between basic biogerontology and clinical brain ageing and by developing new programmes to address the relationship between the healthy ageing brain and the healthy ageing body. By focusing on vitality we will emphasise the considerable potential to deliver major benefits to patients and the general public, as well as reductions in the health and social care costs of an ageing population. The programme on brain ageing will address the following questions: what are the mechanisms of neuronal loss and dysfunction associated with age, how do these mechanisms vary between different neuronal populations and what role do mitochondria play in these processes; what are the links between mechanisms of intrinsic ageing and neurodegeneration/vascular disease, and how is this relationship affected by age-related changes in the neurovascular environment; what is the mechanism and importance of ageing of glial and stem cells? The programme on brain ageing will make use of the extensive (i) Newcastle Brain Tissue Resource (snap frozen and fixed tissue from 1000+ mostly older individuals) and (ii) a dedicated aged mouse unit. The programme on lifelong health and vitality will address the following research questions: what are the mechanisms involved in the protective effect of different forms of exercise on musculoskeletal ageing in terms of physiology, mitochondrial function and muscle/joint pathology; what is the impact of nutritional factors on musculoskeletal and brain ageing with particular emphasis on epigenetic and genetic modifications of nuclear and mitochondrial genomes? To achieve this we will build capacity in exercise physiology, magnetic resonance spectroscopy, in vitro biochemical and molecular methods and nutrition. The MRC Centre?s training programme will include integrated MRes/PhD for 12 students, development of an E-learning MRes, innovative workshops and public lectures. We will work closely with stakeholders and will build elements of research into the process of public engagement into our activities.

Publications

10 25 50
 
Description Brain Ageing and Dementia in Developing Countries
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
 
Description Capacity building in ageing research
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Department of Health Physical Activity Taskforce
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Diabetes UK Science and Research Advisory board
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Gave evidence to House of Lords on Mitochondrial Donation
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact Led to change in UK law to permit the mitochondrial donation technique to be offered to women suffering from mitochondrial disease to prevent transmission of the disease to their children.
 
Description HFEA public consultation
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a national consultation
 
Description House of Commons Select Committee on Mitochondrial Replacement
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL http://www.parliament.uk/business/committees/committees-a-z/commons-select/science-and-technology-co...
 
Description IAH Postgraduate Student training
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Increased number of trained researchers working in ageing research
 
Description International Diabetes Federation mHealth and diabetes global expert working group
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
URL http://www.gsma.com/connectedliving/idf-mou/
 
Description JCM Chair Cross- Council Food Nutrition and Health Steering Group
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description JCM Food Nutrition and Health initiative
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description MRC Nutrition and Health Review Workshop, 7th - 8th July 2016
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description MRC Review of Nutrition and Human Health Research, 14 Oct 2016
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description MRC Review of Nutrition and Human Health research - 17th March
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Mitochondrial Debate drop-in session
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description NU-AGE undergraduate module
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact As a result of participating in this module, undergraduates from faculties other than the Medical Sciences Faculty have chosen undergraduate degree projects to pursue a PhD in ageing research, The NU-AGE teaching module was shortlisted for a CATE by the Higher Education Academy.
URL http://www.ncl.ac.uk/module-catalogue/module.php?code=AGE2000
 
Description Parliamentary Office of Science and Technology
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL http://www.parliament.uk/business/committees/committees-a-z/commons-select/science-and-technology-co...
 
Description Postgraduate Teaching - Masters in Research
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Increased number of trained researchers working in ageing research.
 
Description Presentations to MPs and Peers at Houses of Parliament
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact Houses of Parliament voted to change the law to allow novel IVF techniques to prevent the transmission of mitochondrial disease. HFEA Licensing agreements are not yet confirmed, but once these are in place the technique could potentially benefit 152 women in the UK a year who are at risk of transmitting the disease. 2017 Update: HFEA licensed the treatment for use in the UK in March 2016. Further approval has to be granted by the HFEA for individual treatments.
 
Description Research with Older People e-learning module
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Undergraduate Teaching
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description 40th Annual meeting of the European Environmental Mutagen Society (EEMS), Oslo, Norway
Amount £433 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 09/2010 
End 10/2010
 
Description BMedSci - Intercalated degree Bursary for Amy McWhirter
Amount £5,000 (GBP)
Organisation Association of British Neurologists (ABN) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 08/2018
 
Description BRC Treating mitochondrial dysfunction- mechanisms underlying response to specific compounds
Amount £25,002 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2013 
End 09/2017
 
Description Biomedical Research Centre
Amount £16,600,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Newcastle Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2012 
End 03/2017
 
Description Biomedical Research Unit in Dementia
Amount £4,500,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Newcastle Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 01/2012 
End 03/2017
 
Description Bridging the Urban Divide - UK India initiative
Amount £2,100,000 (GBP)
Organisation Research Councils UK (RCUK) 
Sector Public
Country United Kingdom
Start  
 
Description Can we protect neurons against mitochondrial dysfunction?
Amount £163,787 (GBP)
Funding ID F-1401 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2017 
End 07/2019
 
Description Cancer stem cells in colorectal cancer/Northumbria Healthcare NHS Foundation Trust
Amount £51,980 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description Cardiac manifestations of mitochondrial disease - incidence, mechanisms and treatment
Amount £242,206 (GBP)
Organisation British Psychological Society (BPS) 
Sector Learned Society
Country United Kingdom
Start 04/2010 
End 03/2013
 
Description Clinical training fellowship
Amount £244,514 (GBP)
Organisation Royal College of Psychiatrists 
Sector Learned Society
Country United Kingdom
Start  
 
Description County Durham Primary Care Trust
Amount £450,000 (GBP)
Organisation County Durham and Darlington NHS Foundation Trust 
Sector Public
Country United Kingdom
Start  
 
Description Diagnosing Alzheimer's Disease by measuring proteins in blood
Amount £50,000 (GBP)
Funding ID 105 
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2009 
End 03/2010
 
Description EU Horizon 2020
Amount € 5,559,201 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2018 
End 03/2021
 
Description Gordon Research Conference Travel Award
Amount £800 (GBP)
Organisation European Environmental Mutagen Society (EEMS) 
Sector Charity/Non Profit
Country European Union (EU)
Start  
 
Description Keystone Scholarship/National Institutes of Health, National Institute on Aging Grant #1R13AG034755-01.
Amount £625 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start  
 
Description LLHW Industrial Link Supplement
Amount £242,880 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MORNINGSIDE Ventures
Amount £390,087 (GBP)
Organisation Morningside Venture Capital 
Start 10/2016 
End 09/2018
 
Description MRC Exercise Lab
Amount £759,103 (GBP)
Funding ID G0802536 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2009 
End 12/2013
 
Description Mechanisms of neurodegeneration and regeneration in post stroke dementia
Amount £87,970 (GBP)
Funding ID ARUK-PG2013-22 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2013 
End 09/2016
 
Description Mission Therapeutics
Amount £25,831 (GBP)
Organisation MISSION Therapeutics 
Sector Private
Country United Kingdom
Start 11/2016 
End 08/2017
 
Description NIHR Biomedical Research Centre
Amount £101,109 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 01/2016 
End 03/2017
 
Description NIHR Senior Investigator
Amount £60,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2009 
End 04/2012
 
Description NIHR Senior Investigator Award
Amount £45,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2015 
End 03/2018
 
Description NIHR Senior Research Fellowship
Amount £989,710 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description National Horizon Scanning Centre
Amount £8,000,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Central Commissioning Facility
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description Newcastle BRC
Amount £9,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Newcastle Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 01/2010 
End 12/2010
 
Description Newcastle Healthcare Charity
Amount £157,489 (GBP)
Organisation Newcastle upon Tyne Hospitals NHS Foundation Trust 
Department Newcastle Healthcare Charity
Sector Charity/Non Profit
Country United Kingdom
Start 09/2013 
End 08/2016
 
Description Parkinson's UK Fellowship
Amount £249,958 (GBP)
Funding ID F-1401 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2014 
End 06/2017
 
Description Participation fee for 17th ENLP Seminars, Luxembourg 2011
Amount £600 (GBP)
Organisation European Nutrition Leadership Programme (ENLP) 
Sector Learned Society
Country Netherlands
Start 03/2011 
End 04/2011
 
Description Public engagement funding
Amount £7,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2013 
End 04/2013
 
Description RCUK Lifelong Health and Wellbeing (LLHW)
Amount £2,907,201 (GBP)
Funding ID M501700 
Organisation Research Councils UK (RCUK) 
Sector Public
Country United Kingdom
Start 06/2014 
End 06/2019
 
Description Regional health Innovation and education cluster (Evaluation of the Movement as Medicine pathway in T2 diabetes)
Amount £100,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description Sport England
Amount £150,000 (GBP)
Organisation Sport England 
Sector Public
Country United Kingdom
Start 08/2013 
End 07/2015
 
Description Studentship:Monogenetic mitochondrial disorders
Amount £55,556 (GBP)
Organisation Novartis 
Sector Private
Country Global
Start 02/2013 
End 02/2017
 
Description Technical Training Fund/Newcastle University
Amount £500 (GBP)
Organisation Newcastle University 
Sector Academic/University
Country United Kingdom
Start  
 
Description UKEMS Conference Travel Award
Amount £500 (GBP)
Organisation United Kingdom Environmental Mutagen Society 
Sector Learned Society
Country United Kingdom
Start  
 
Description Understanding the Ageing Heart workshop
Amount £3,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust Centre for Mitochondrial Research
Amount £4,500,000 (GBP)
Funding ID 096919 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2012 
End 04/2017
 
Description adaption to the Movement as Medicine programme
Amount £155,000 (GBP)
Organisation Sport England 
Department County Durham Sport
Sector Private
Country United Kingdom
Start 10/2013 
End 06/2015
 
Description e-therapeutics collaboration - testing compounds
Amount £112,665 (GBP)
Organisation e-Therapeutics 
Sector Private
Country United Kingdom
Start 12/2013 
End 11/2014
 
Title Establishment of the Physical Activity and Exercise Research Group 
Description Funding allowed pump priming for the development of the laboratory and core staff. 
Type Of Material Improvements to research infrastructure 
Year Produced 2009 
Provided To Others? Yes  
Impact Significant increase in physical activity and exercise research. Prior to this program approximately 30 people per year took part in physical activity or exercise research in Newcastle.In 2010 over 400 people took part in physical activity and exercise research across ageing, metabolic and neuromuscular disease. 
 
Title Immunohistochemistry to diagnose mitochondrial disease 
Description Improving the diagnosis of mitochondrial disease in muscle biopsies using a quadruple immunofluorescence technique 
Type Of Material Biological samples 
Year Produced 2015 
Provided To Others? Yes  
Impact This research method has been adopted in our diagnostic protocol. 
 
Title MOVEeCloud 
Description An online open analytical method for the collection and assessment of movement and sleep. 
Type Of Material Improvements to research infrastructure 
Year Produced 2013 
Provided To Others? Yes  
Impact MOVEeCloud is the first scalable secure platform for the collection, sharing and analysis of movement data. It reduces analytical processing time by over 90% and also allows common use of processing techniques. 
URL http://www.moveecloud.com
 
Title Mito Disease Cohort UK 
Description A database of around 1503 patients with mitochondrial disease, 964 of which were collected in Newcastle. 
Type Of Material Database/Collection of data 
Year Produced 2011 
Provided To Others? No  
Impact All patient data collected is being used to develop clinical guidelines and enrolment in clinical trials. 
 
Description Collaboration with Harvard University 
Organisation Harvard University
Department Harvard Medical School
Country United States 
Sector Academic/University 
PI Contribution Analysis of single cells, laser microdissection
Collaborator Contribution Expertise in single molecule PCR
Impact Greaves LC, Beadle NE, Taylor GA, Commane D, Mathers JC, Khrapko K, Turnbull DM. Quantification of mitochondrial DNA mutation load. Aging Cell 2009a; 8: 566-72. Multidisciplinary involving molecular genetics, cell biology
Start Year 2008
 
Description Collaboration with Kyoto University 
Organisation University of Kyoto
Country Japan 
Sector Academic/University 
PI Contribution Expertise in characterisation of the pathology of white matter changes in a mouse model of cerebral hypoperfusion. The collaboration has led to the development of a modified version of the mouse model on site within the CBAV by Dr Lucy Craggs.
Collaborator Contribution Characterisation of a mouse model of brain hypoperfusion
Impact Kitaguchi H et al. Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice. Brain Res. 2009; 1294:202-10.
Start Year 2008
 
Description Collaboration with Munich University 
Organisation Ludwig Maximilian University of Munich (LMU Munich)
Country Germany 
Sector Academic/University 
PI Contribution Tissue resource from NBTR, single neuron analsyis
Collaborator Contribution Expertise in microarray analysis
Impact Elstner et al Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. Ann Neurol 2009; 66: 792-8. Multidisciplinary involving geentics and neuropathology
Start Year 2009
 
Description Collaboration with UCL 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in muscle disease and sarcopenia. This is close working between two MRC Centres. Professor Hanna directs the MRC Translational Centre for Neuromuscular Disorders
Collaborator Contribution Expertise in muscle disease
Impact Joint conference on Neuromuscular diseases
Start Year 2008
 
Description Collaboration with University of Calgary 
Organisation University of Calgary
Country Canada 
Sector Academic/University 
PI Contribution Expertise in mitochondrial analysis of muscle and spinal cord
Collaborator Contribution Animal model and expertise in animal exercise physiology
Impact New insights into sarcopenia, multidisciplinary involving clinical, histopathological, molecular genetics and exercise physiology
Start Year 2009
 
Description Collaboration with University of Edinburgh 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in mitochondrial genetics
Collaborator Contribution Expertise in genetics
Impact Wright AF, Murphy MP, Turnbull DM. Do organellar genomes function as long-term redox damage sensors? Trends Genet 2009; 25: 253-61
Start Year 2008
 
Description Collaboration with University of Edinburgh - Mouse Model 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution This collaboration is with Dr K Horsburgh of the Centre for Cognitive Ageing and Cognitive Epidemiology. Expertise in characterisation of the neuropathological changes in a mouse model of cerebral hypoperfusion. The collaboration is expected to lead to the development of another mouse model on site within the CBAV.
Collaborator Contribution Characterisation of mouse models of brain hypoperfusion
Impact Coltman R et al. Selective white matter pathology induces a specific impairment in spatial working memory. Neurobiol Aging, in press.
Start Year 2008
 
Description Collaboration with University of Liverpool 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in mitochondrial analysis of muscle and spinal cord
Collaborator Contribution Animal model and expertise in free radical biology
Impact New insights into sarcopenia, multidisciplinary involving clinical, histopathological and molecular genetics
Start Year 2009
 
Description Collaboration with University of Texas 
Organisation University of Texas
Country United States 
Sector Academic/University 
PI Contribution Analysis of muscle biopsies from patients undergoing exercise regimes
Collaborator Contribution Exercise physiology
Impact Murphy JL, Blakely EL, Schaefer AM, He L, Wyrick P, Haller RG, Taylor RW, Turnbull DM, Taivassalo T. Resistance training in patients with single, large-scale deletions of mitochondrial DNA. Brain 2008a; 131: 2832-40. Multidisciplinary involving exercise phsyiology, clinical and molecular genetics
Start Year 2007
 
Description Collaboration with University of Wisconsin USA 
Organisation University of Wisconsin-Madison
Country United States 
Sector Academic/University 
PI Contribution The mitochondrial mutator mice will be used as a model of stem cell aging and cancer.
Collaborator Contribution Wisconsin have provided the mitochondrial mutator mice and we are beginning a breeding programme in Newcastle.
Impact no output yet
Start Year 2011
 
Description Developing new drugs for mitochondrial dysfunction 
Organisation Novartis
Country Global 
Sector Private 
PI Contribution Novartis are funding a studentship within the Centre and we are helping their screening progamme
Collaborator Contribution They are funding a studentship
Impact No outcomes yet - just starting
Start Year 2012
 
Description Japan - RNK 
Organisation National Cerebral and Cardiovascular Centre
Department Department of Stroke and Cerebrovascular Diseases
Country Japan 
Sector Hospitals 
PI Contribution Developing an animal model of vascular dementia. My team provided the pathological reports on our dementia cases
Collaborator Contribution Developing and testing the model after assessing the pathological changes in brains from vascular dementia and post-stroke patients
Impact A publication describing a new animal model of vascular dementia [PubMed PMID: 22133276 Kitamura et al, 2012].
Start Year 2012
 
Description Lifestyle and metabolic control 
Organisation Unilever
Department Unilever Research and Development
Country United Kingdom 
Sector Private 
PI Contribution CASE PhD studentship - Unilever are providing expertise on analytics and big data analysis and skin.
Collaborator Contribution They provided the CASE studentship funding.
Impact No outputs yet
Start Year 2016
 
Description Liverpool Univeristy CIMA 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution We are collaborating with Liverpool University as part of the MRC / ARUK Centre for Integrated Musculoskeletal Ageing on a study looking at sedentary behaviour and muscle ageing.
Collaborator Contribution Both sites are contributing clinical facilities and support.
Impact Research still active.
Start Year 2013
 
Description Maastricht University 
Organisation Maastricht University (UM)
Country Netherlands 
Sector Academic/University 
PI Contribution Molecular studies on samples collected in Maastricht
Collaborator Contribution Maastricht provided samples for molecular studies
Impact No outputs yet. This is a multidisciplinary study involving molecular biologists, exercise physiologists and physicians.
Start Year 2011
 
Description Max Planck Institute 
Organisation Max Planck Society
Department Max Planck Institute for the Biology of Ageing
Country Germany 
Sector Academic/University 
PI Contribution assessment of the use of mitochondrial mutator mouse as a model of stem cell aging and development of a mouse model of a human mitochondrial myopathy. We have carried out comprehensive histochemical and molecular analysis of gut tissues at the single cell level. We are now performing single cell analyses of gut tissue from a mouse model of disease being developed at the Max Planck Institute.
Collaborator Contribution The collaborators provided heterozygous mutator mice.
Impact One publication in Mechanisms of Ageing and Development, 2014
Start Year 2011
 
Description NUTRIM 
Organisation Maastricht University (UM)
Department School for Nutrition, Toxicology and Metabolism (NUTRIM)
Country Netherlands 
Sector Academic/University 
PI Contribution We are supporting direct measurements of liver glycogen by NMR.
Collaborator Contribution Expertise on exercise and nutrition.
Impact None yet.
Start Year 2013
 
Description Understanding the interaction of alpha-synuclein with mitochondria 
Organisation University College London
Department Department of Molecular Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution cell lines
Collaborator Contribution alpha-synuclein and live cell imaging techniques
Impact Two research papers are currently in preparation.
Start Year 2013
 
Description Unilever - Physical activity monitoring platform 
Organisation Unilever
Country United Kingdom 
Sector Private 
PI Contribution One of the senior postdoctoral researchers is ocordinating the physicial activity monitoring platform.
Collaborator Contribution This is a joint project
Impact Joint project grant. This is a multidisciplinary project involving designers, software engineers, physiologists, physicians, physiotherapists and signal processors.
Start Year 2011
 
Description University of Southampton - RNK 
Organisation University of Southampton
Department Faculty of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research reagents and biological tissues from cases diagnosed in Newcastle
Collaborator Contribution Providing research reagents
Impact Joint publications [PubMed PMID: 23413811 Hawkes CA et al, 2013 and PubMed PMID: 23489283 Carare RO et al, 2013, NAN].
Start Year 2012
 
Description etherapeutics 
Organisation e-Therapeutics
Country United Kingdom 
Sector Private 
PI Contribution Experimental activities will be performed in the Mitochondrial Research Group lab.
Collaborator Contribution All pharmaceuticals to be provided by the collaborator.
Impact none yet
Start Year 2013
 
Title MOVEeCloud 
Description This is a cloud-internet based physical activity, function and sleep analysis platform developed in collaboration with the RCUK Social Inclusion through the Digital Economy hub in Newcastle. 
Type Support Tool - For Fundamental Research
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2011
Development Status Under active development/distribution
Impact none yet 
 
Title Movement as Medicine 
Description The UK's first professional and patient development pathway for physical activity in the care of Type 2 diabetes. 
Type Therapeutic Intervention - Physical
Current Stage Of Development Initial development
Year Development Stage Completed 2011
Development Status Under active development/distribution
Impact not known 
 
Description 2B North East Polish/English Newspaper 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Published interview with one of the CBAV postdoctoral researchers in a North East Polish/English newspaper.
http://translate.google.com/translate?js=y?v=_t&hl=en&ie=UTF-8&layout=1&eotf=1&u=2b.nepco.org.uk&sl=pl&tl=en

unknown
Year(s) Of Engagement Activity 2011
 
Description 5th Joint ESN & Biochemical Society Conference, Bath - ES 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PhD student was selected to give an Oral Presentation - Assessing Mitochondrial Dynamics in Newly Differentiated Neurons through Total Internal Reflection Microscopy (TIRF) and Surface.
5th Conference on Advances in Molecular mechanisms underlying neurological disorders. 23-26 June 2013,Bath, UK

the student was subsequently invited to write a review, "Monitoring mitochondrial dynamics and complex I dysfunction in neurons: implications for Parkinson's disease" which will be published in Biochem Transactions in November 2013.
Year(s) Of Engagement Activity 2013
URL http://www.jointesn-bs2013.org/Home.aspx
 
Description APPG Houses of Parliament 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Gave evidence to the APPG on Health about the proposed changes to the law to allow IVF procedures that will help to reduce the risk of passing on mitochondrial disease to children.
Year(s) Of Engagement Activity 2015
 
Description Alzheimer's Research Public Awareness Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact CBAV students and postdocs presented posters and spoke at the Annual ARUK Public Awareness Day in Newcastle on 19 September 2012. The event was well attended by the general public.

not known
Year(s) Of Engagement Activity 2012
 
Description Alzheimer's Research UK Supporters Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach Regional
Primary Audience Supporters
Results and Impact This event was held in Newcastle on 13 October 2012. CBAV postdocs and PhD students were invited to present posters and talks highlighting the work they are doing in collaboration with researchers funded by ARUK. The event was well attended by supporters of ARUK and their families and friends.

not known
Year(s) Of Engagement Activity 2012
 
Description Annual NCCR meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Kalaria gave the evening public lecture on hypertension and dementia

not known
Year(s) Of Engagement Activity 2009
 
Description BBC Documentary on Ageing 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact I led a three part documentary for the BBC on how to Age Well that was broadcast in 2017 and watched by in excess of 12million people in the UK and 5million overseas.
Year(s) Of Engagement Activity 2017,2018
URL http://www.bbc.co.uk/programmes/articles/2YTnV1QS0l6Gbkyf0FcKhM3/test-your-lifestyle-how-are-you-age...
 
Description Big Bang Fair 2012 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Two of our postdoc researchers applied and were accepted to participate in the MRC stand at the Big Bang Fair 2012.
The MRC Regional communications manager is meeting with the postdocs soon to discuss ideas for the stand.

not yet known
Year(s) Of Engagement Activity 2011
 
Description Big Bang Fair 2012, NEC Birmingham 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Postdocs and PhD students from CBAV provided input into the design of the MRC stand at the Big Bang Fair 2012. The activity is aimed at encouraging young people to consider careers in science and engineering.

not known
Year(s) Of Engagement Activity 2012
 
Description Biotechnology Yes - OR 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Two CBAV PhD students won a prize for the best presentation at the event.

none known
Year(s) Of Engagement Activity 2012,2013
URL http://www.biotechnologyyes.co.uk/
 
Description Brain Mind and Cognition Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Kalaria gave lecture on the brain ageing, stroke and dementia.

not known
Year(s) Of Engagement Activity 2009
 
Description British Science Festival 2013 - DMT 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CBAV Director led a public discussion, chaired by the Head of Communications at the Wellcome Trust, about the new IVF technique to prevent mitochondrial disease. The technique has generated huge international media interest.


UK Government have approved publication of revised draft regulations allowing this research to go ahead.
Year(s) Of Engagement Activity 2013
 
Description British Science Festival 2013 - Brain Hats 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Schools
Results and Impact The stand was very popular, with hundreds of schoolchildren participating in the activities over the course of the 4-day festival.

not yet known
Year(s) Of Engagement Activity 2013
URL http://www.britishscienceassociation.org/british-science-festival/newcastle-2013
 
Description British Science Festival 2013 - RNK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact CBAV co-director was a panel discussant (panel was chaired by another co-director) on 'Ageing - the challenge of our time'. The activity was organised by ARUK in conjunction with Newcastle University's initiative on Changing Age.

One in four children born today will
celebrate their 100th birthday. Tom
Kirkwood led a panel of experts in
exercise, technology and brain health to
explore how science is addressing the
challenges and opportunities that living
longer presents. The event generated lively discussion.
Year(s) Of Engagement Activity 2013
URL http://www.britishscienceassociation.org/british-science-festival/newcastle-2013
 
Description CBAV website - 'Spotlight on ..' 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Monthly 'spotlight on' articlespublished on the CBAV website to give information about our researchers and their work in an informal and friendly way.
A different profile is published each month.
http://www.ncl.ac.uk/cbav/engagement/SpotlightOn.htm

not known
Year(s) Of Engagement Activity 2012
 
Description Cafe Scientifique, Stockton on Tees 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Co-director of CBAV was invited to give a talk about, "Increasing human longevity," followed by a lively discussion with participants at the meeting.

not known
Year(s) Of Engagement Activity 2012
 
Description Canadian Health Institute for Research special emphasis panel 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Prof Kalaria delivered a current review on risk factors for brain ageing and neurodegeneration

not known
Year(s) Of Engagement Activity 2009
 
Description Cheltenham Literary Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Following a very positive response to a presentation made at the Cheltenham Science Festival, the Director of CBAV was invited to present a talk explaining the role of mitochondria in disease to a lay audience at the Cheltenham Literary Festival.

not known
Year(s) Of Engagement Activity 2012
 
Description Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Director of CBAV was invited to explain mitochondria and mitochondrial disease to a lay audience at the Cheltenham Science Festival on 15 June 2012.

Following a positive response from the public audience, the CBAV Director was invited to to present at the Cheltenham Literary Festival.
Year(s) Of Engagement Activity 2012
URL http://www.cheltenhamfestivals.com/literature/
 
Description Coming of Age event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Centre-funded researchers participated in the Art and Science of Ageing event at the Great North Museum - a dynamic exhibition bringing together the scientific and artistic communities by exploring aspects of ageing and life expectancy.
The exhibition, built around three themes of biology, frailty and vitality, ran from 12 Jan to 2 March 2011 and was inspired by Newcastle University's Changing Age campaign which seeks to challenge the negative perceptions about older people in society. Coming of Age used art to explore how and why we age, the effects of ageing and the lives of older people through the eyes of both artists and scientists.

The exhibition was very well attended throughout the whole period and received very positive reviews and comments in the national and regional press, including The Guardian, Grazia magazine, and The Journal.
Year(s) Of Engagement Activity 2011
 
Description DMT - British Myology Society talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk led to several questions and discussion afterwards.

none yet known
Year(s) Of Engagement Activity 2014
URL http://www.cnmd.ac.uk/seminars_courses_workshops/courses_workshops/current-conferences-workshop/annu...
 
Description DMT After dinner talk - British Myology Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact After dinner speech at the annual meeting of the British Myology Society stimulated much discussion afterwards.

Increased awareness of the research happening in Newcastle which could lead to future collaborations.
Year(s) Of Engagement Activity 2014
URL http://www.cnmd.ac.uk/seminars_courses_workshops/courses_workshops/current-conferences-workshop/annu...
 
Description DMT Max Planck Cologne 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote speech at the Max Planck Institute Symposium in Cologne. Talk generated a lot of questions and discussion.

continued collaboration with researchers at the Max Planck Institute
Year(s) Of Engagement Activity 2014
 
Description DUK National Patient Engagement Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Talk entitled, 'Standing up for Type 2 diabetes' to the Diabetes UK National Patient Engagement Day in June 2012

not known
Year(s) Of Engagement Activity 2012
 
Description Diabetes UK Science and Research Advisory Board 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Health professionals
Results and Impact Member of the Diabetes UK working group setting the scientific direction of research undertaken by DUK.

Links with Diabetes UK and other researchers as well as influencing research direction across the UK.
Year(s) Of Engagement Activity 2013
 
Description Diabetes UK Volunteer Group event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact This event followed earlier focus group meetings. The aim was to develop intervention materials for use in people with high risk of developing T2 diabetes.
A PhD student gave a presentation, followed by a discussion to a group of adults with Type 2 diabetes and their relatives, friends and carers.

Six individuals with T2 diabetes and their partners, friends and relatives agreed to review intervention materials.
Year(s) Of Engagement Activity 2012
 
Description Dutch Society for Research on Ageing conference, Lieden, Netherlands. May 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Preseantation of findings from ongoing research on personalised nutrition and opportunities for application to improve healthy ageing
Year(s) Of Engagement Activity 2017
URL http://www.nvvvo.nl/nvvvo.nl/?lang=en
 
Description Edinburgh Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact One of the PhD students took part in an interactive activity demonstrating various aspects of brain ageing at the Edinburgh Science Festival. http://www.sciencefestival.co.uk/

not known
Year(s) Of Engagement Activity 2012
 
Description Elders Council Radio interview 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Dr Gorman was interviewed for the Elders Council radio programme on a local Newcastle radio station about why an active lifestyle and its relationship to older people's quality of life, with particular reference to the effect of physical activity on cognitive ability.

not known
Year(s) Of Engagement Activity 2010
 
Description Eve's Curse: the art of mitochondrial research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact This was a week-long exhibition from 11-17 March 2013 held in the Great North Museum, a public art gallery in Newcastle, which allowed hundreds of members of the public and groups of schoolchildren to participate in the activity, as well as the community art groups that were involved in producing the art work for the event.
http://www.newcastle-mitochondria.com/testi/brain-awareness-week-exhibition/

The installation was a success largely due to the interaction of scientists, during February and early March, with professional artists, school children and community groups in the North East, discussing the many different facets of the research groups' interest in mitochondria and the brain. This resulted in the transformation of colourful and dramatic scientific images into vibrant artworks, including sculptures, paintings, models, and digital prints, of which over 200 were submitted. These were showcased alongside our scientific images to form the narrative of our exhibition.

The week culminated in a celebration and awards evening for over 100 guests, where we had the opportunity to congratulate everyone who had participated for their enthusiasm and support, and also to award the prize-winning artists!
Year(s) Of Engagement Activity 2013
 
Description Event celebrating the MRC Centenary Awards 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This event was organised by Newcastle University Graduate School to bring together all MRC-funded students as one 'cohort'. This included students awarded MRC studentships through the annual Faculty competition, CASE students, Clinical Training Fellows and CBAV students as well as students funded by N3CRs. All students were asked to provide a brief abstract to demonstrate how their PhD matches the MRC strategy. A series of presentations was given from MRC Centenary Winners and current PhD students, including some of the CBAV PhD students.

All delegates received a copy of the collected abstracts and these will also be presented to the MRC when they visit Newcastle University in November.
Year(s) Of Engagement Activity 2013
 
Description Fit as a Falcon 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Approximately 500 schoolchildren attended an event held at the Newcastle Falcons Rugby Club over two days. Our students and postdoctoral researchers demonstrated different aspects of our research using various activities. The Falcons Rugby Community Foundation team also hosted an activity. The children moved around the different activities and participated in them all. On the second day running alongside our event, there was an event organised in conjunction with Greggs Bakery around their 'Tackling Health' initiative teaching about healthy cooking and eating. Other local business people were invited to this event so they were also able to visit our activities and engage with the researchers.Feedback from the children was extremely positive and they all enjoyed the day. We also had excellent feedback from our students and researchers about how much they had gained from participating in the engagement event.
Year(s) Of Engagement Activity 2017
 
Description Geordie Sinatra 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact http://www.ncl.ac.uk/biomedicine/news/newsitem.htm?id=save
Newcastle University Changing Age team, researchers and patients worked with writers to better understand the experience of living with dementia. The result was a new play, Geordie Sinatra, which was performed at the Live Theatre in Newcastle in Apr/May 2012.

not known
Year(s) Of Engagement Activity 2012
 
Description HFEA public consultation 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Director of CBAV was invited to explain mitochondria and disease to a lay audience at an HFEA public consultation into a pioneering mitochondrial technique on 21 July 2012. http://www.ncl.ac.uk/iah/news/news/item/public-consultation-launched-into-pioneering-mitochondrial-technique

The HFEA has launched a public consultation debating the ethics of mitochondria replacement.
http://www.hfea.gov.uk/7517.html
Year(s) Of Engagement Activity 2012
URL http://www.ncl.ac.uk/iah/news/news/item/public-consultation-launched-into-pioneering-mitochondrial-t...
 
Description House of Commons Select committe on mitochondrial replacement 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Increased awareness of the mitochondrial transfer technique and what it involves.

No decision has been made to approve the technique or otherwise, but it is anticipated that the legislation will come before Parliament early in 2015.
Year(s) Of Engagement Activity 2014
URL http://www.parliament.uk/business/committees/committees-a-z/commons-select/science-and-technology-co...
 
Description I'm A Scientist get me out of here 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Schools
Results and Impact Three of the CBAV PhD students took part in the competition in which the school pupils get to ask questions of the scientists and vote off the least popular scientists.

not yet known
Year(s) Of Engagement Activity 2011
 
Description IAH-IGM Joint Postgraduate Research Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact PhD student presented her research, "Cognitive functioning in adult patients with mitochondrial disease," to peers at a Newcastle University cross-institute research day.

This is an annual event organised between the Institute of Ageing & Health and another research institute within the Faculty of Medical Sciences to encourage collaboration between institutes and raise awareness of other research within the Faculty.
Year(s) Of Engagement Activity 2013
 
Description ICM Schools Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Schools
Results and Impact A group of high school students visited the MoveLab exercise research facility. PhD students and postdoc researchers showed them round and explained the equipment to them and how it helped to find out the effect of exercise on health. The students were very interested and several expressed an interest in learning more about exercise science.
http://www.ncl.ac.uk/icm/news/engagement/mrvisit/index.htm

This was a follow-up activity following a very successful similar event run the previous year.
Year(s) Of Engagement Activity 2012
 
Description International Diabetes Federation mHealth Expert Working Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact I am a member of the IDF expert working group on mHealth developing policy advice on mobile technologies and their role in diabetes in partnership with the global mobile phone representative body (GSMA).

Links with policy forming groups and industry.
Year(s) Of Engagement Activity 2013
URL http://www.idf.org/
 
Description John Mathers TV interview - 9 November 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Prof Mathers was interviewed on Tyne Tees television about nutrition, lifestyle and healthy ageing.

not known
Year(s) Of Engagement Activity 2010
 
Description Keeping active matters 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Engagement event on the benefits of physical activity for members of our Voice North panel and members of the public. Researchers gave talks during a number of interactive sessions.

not yet known
Year(s) Of Engagement Activity 2014
 
Description Lab tours 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Supporters
Results and Impact We are happy to offer guided tours of our labs to any members of the public or patients who contact us. These are generally people who are in some way affected by mitochondrial disease and many are involved in fundraising activities on our behalf. They are interested to see how the funds are used for research and are able to ask the researchers questions.

Many people who have the opportunity to talk to researchers and visit the labs continue their involvement in raising awareness of mitochondrial disease and fundraising to support the research.
Year(s) Of Engagement Activity 2014
 
Description Latitude Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact All the sessions were well-attended and provoked lively and interesting discussions with the audience.



none known
Year(s) Of Engagement Activity 2013
URL http://www.latitudefestival.com/
 
Description Leading Edge 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Visits by groups of school children to our research laboratories as part of the 'Leading Edge' initiative to help students grasp basic scientific techniques and provide an insight into our research activities.
Year(s) Of Engagement Activity 2017
URL https://blogs.ncl.ac.uk/leadingedge/
 
Description Leading Edge 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Schools
Results and Impact Two different groups of Year 9 students and their teachers from local schools came into the lab on two separate occasions to work with researchers. Students also attended a presentation skills workshop and learned lab skills. We developed a 'Mitomag' cartoon magazine to help the students understand mitochondrial genetics.

The children and their teachers all reported they had enjoyed the day and said they didn't realise science was so much fun!
Year(s) Of Engagement Activity 2014
 
Description Led the mHealth tour 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact I led the worlds first mHealth bike ride from Brussels to Barcelona to raise awareness of type 1 diabetes and the role of technology.

Connection with patients and companies involved in digital health and diabetes.
Year(s) Of Engagement Activity 2013
URL http://www.mhealthtour.com
 
Description LibDem Party Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact This was an opportunity to present our work to Liberal Democrat MPs, Fellows of the Royal Academies and members of other Learned Societies during the Lib Dem conference in Glasgow at a meeting organised by the Academy of Medical Sciences. This was followed by a discussion about the challenges of influencing policy through research.

Raised awareness among policymakers about the research happening in Newcastle.
Year(s) Of Engagement Activity 2014
 
Description MRC Centenary Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact There were over 1800 visitors to the Centre for Life over the two days of the event and the majority of them seemed to find their way to the display. It was very busy and we had really positive feedback from everyone we spoke to.

Everyone who completed a form reported that they found the activities interesting and the researchers helpful and engaging. The feedback forms also showed that 42% of people who completed a feedback form had not previously met a research scientist and 63% were previously unaware of any research funded by the Medical Research Council. All respondents reported that they would attend a similar event in the future.

All the scientists who took part in the event enjoyed it as much as the members of the public who participated. Most of them commented on how rewarding it is to talk about their work and see that people are so interested in what they are doing.
Year(s) Of Engagement Activity 2013
URL http://www.ncl.ac.uk/cbav/engagement/MRCCentenaryEvent.htm
 
Description Marabou Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Prof Kalaria gave lecture on the vascular basis of neurodegeneration. A review of this lecture is 'in press' in Nutritional Reviews.

not known
Year(s) Of Engagement Activity 2009
 
Description Meet the Scientist Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Along with colleagues from the Centre for Brain Ageing & Vitality, one of our postdoctoral researchers organised and ran a 'Meet the Scientist' stand offering visitors to the Centre for Life an opportunity to hear about the research going on at Newcastle University. There were interactive displays which allowed the children to have a 'hands-on' experience of science.
The day was a resounding success and the stand attracted dozens of interested children and parents.


The following comments were received from the attraction engagement manager:

"Thank you so much for a really successful Meet the Scientist Event yesterday! We had over 800 visitors yesterday and I think lots of them found their way to your brain power zone! The
activities were great, from the sweetie DNA to real brain cells under the microscope, there seemed to be something for everyone. The best part of course was you and your team of
enthusiastic researchers! We're always thrilled when we can offer visitors the chance to talk to real scientists, as we know it's something that they really appreciate.
Please pass my thanks on to your colleagues too. I know that one or two of them mentioned having colleagues in other departments who would be interested in taking part in a Meet the Scientist Event, so please pass on my contact details too.
We love you to join us again sometime in the future. Just let us know which dates would suit you.
I thought you and your colleagues might also be interested in taking part Bright Club, where researchers take to the stage to talk about the funny side of their research.
http://www.life.org.uk/whats-on/events/bright-club-newcastle-3"
Year(s) Of Engagement Activity 2011
 
Description Mini Medical School for Older People 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 50 people attended a workshop at the Newcastle University Centre for Life.

Gave an insight into what research is happening in Newcastle and how the medical profession is involved in research.
Year(s) Of Engagement Activity 2011
 
Description Mito matters event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Members of the public were invited to discuss concepts in mitochondrial genetics and biology. The day included lectures using turning point, a world café style session and an interactive discussion, which involved a pre-event briefing and discussion for those members of the public who wanted to have their voice heard in issues surrounding mitochondrial donation.

Mitochondrial donation is a contentious issue which many people know little about. Those people who attended were keen to be involved in future events and learn more about mitochondrial disease and potential treatments.
Year(s) Of Engagement Activity 2014
 
Description Mitochondrial patient information day June 2010 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact A patient information day for Mitochondrial patients to find out more about their disease and the research that is being carried out to improve treatment and care was held in The Sage, Gateshead.

not known
Year(s) Of Engagement Activity 2010
 
Description NE Humanist Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presented a lecture on "New advances in medical research" to the North East Humanist Society which was followed by questions and a discussion

not known
Year(s) Of Engagement Activity 2010
 
Description NIHR Ageing Biomedical Research Centre lectures 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact One of 6 keynote lectures on ageing to a nationally representative group.

Links with other groups and awareness of ageing.
Year(s) Of Engagement Activity 2012,2013
 
Description Nature Neuroscience podcast 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact One of the CBAV postdocs was invited to discuss a recent review paper. The discussion was published as a podcast on the Nature website in May 2012 as part of their Neuropod series. http://www.nature.com/neurosci/neuropod/index-2012-05-28.html

not known
Year(s) Of Engagement Activity 2012
 
Description Neuro 2013 presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PhD student gave a talk at Neuro 2013, "Relationship between mutation load, EEG and cognitive functioning in patients with mitochondrial DNA disease." in Kyoto, Japan

impact not yet known
Year(s) Of Engagement Activity 2013
URL http://www.sfn.org/annual-meeting/neuroscience-2013
 
Description Newcastle Diabetes UK voluntary group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Over 40 people belonging to the Diabetes UK patient group attended a lecture about physical activity. There was a lengthy question and answer session and a good deal of discussion afterwards.

Provided information to people about how physical activity can be used as an effective 'medicine' to treat diabetes.
Year(s) Of Engagement Activity 2011
 
Description Newcastle Science Festival 2010 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presented a poster entitled, "Should you put all your eggs in one basket? Fitting another piece to the Parkinson's disease puzzle." Attendees asked questions and discussed the findings.

not known
Year(s) Of Engagement Activity 2010
 
Description Newcastle Science Festival 2012 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Postdocs and PhD students from CBAV participated in the Science Festival, manning stands and interacting with visitors.

not yet known
Year(s) Of Engagement Activity 2012
 
Description Newcastle University engagement activities 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Centre continues to provide funding towards the salary of Newcastle University's Public Engagement Team. The University has a broad programme of engagement activities. Over the last 12 months there have been over 15 events aimed at disseminating the University's research and activity to the general public. They communicate the activities of CBAV on a monthly basis through Voice North (the Regional Engagement Panel made up of a group of over 700 people reflecting the ag- structure and geographical and socioeconomic make-up of the North East) communications and events and through Years Ahead, the North East Regional Forum on Ageing.

The activities of the public engagement team raise awareness of the research being undertaken by the Centre and the University as a whole. Voice North provides focus groups which contribute to the development of research projects and provide participants for research projects.
Year(s) Of Engagement Activity 2008,2009,2010,2011
 
Description One-to-one discussions with patients from a primary care practice 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact The aim of the activity was to engage adults with T2 diabetes in the development of intervention materials. 12 adults with T2 diabetes contributed to developing the materials. Refinements were made based on feedback from the group.

Intervention materials were subsequently entered into an open pilot in primary care.
Year(s) Of Engagement Activity 2012
 
Description Parliamentary Office of Science and Technology 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presentation at the seminar sparked animated discussion about the pros and cons of the technique.

not yet known
Year(s) Of Engagement Activity 2014
URL http://www.parliament.uk/mps-lords-and-offices/offices/bicameral/post/post-events/preventing-mitocho...
 
Description Parliamentary debate on mitochondrial transfer techniques 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Researchers from Newcastle University together with patients suffering from mitochondrial disease held a drop-in session at the House of Commons prior to a parliamentary debate on the safety of mitochondrial transfer techniques. The session was to provide information to MPs on how the disease affects sufferers and how the replacement techniques could prevent transmission of the disease to future generations. A number of MPs attended the session.

A decision has not yet been made on whether the techniques should be approved, but it is anticipated the debate will go ahead early in 2015.
Year(s) Of Engagement Activity 2014
 
Description Patient Information Day - London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact A Patient Information Day was held in London for local patients, carers and relatives. The day included discussion about the cohort and how patients could get involved.

A number of patients were recruited to the study as a result of the information day, and awareness of the cohort study in general was increased.
Year(s) Of Engagement Activity 2009
 
Description Patient Information Day - Newcastle 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact A patient information day for patients, carers and relatives. This gave information on a range of subjects related to mitochondrial disease, with a specific section of the day devoted to providing information about this cohort.

We were able to recruit a number of patients as a result of the information provided, and raised awareness of the cohort in the patient gorup.
Year(s) Of Engagement Activity 2009
 
Description Patient Information Event Gateshead 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact One of the Principal Investigators on the project participated at a Patient Information Event held in Gateshead in June 2010/

not known
Year(s) Of Engagement Activity 2010
 
Description Patient feedback evening 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Around 30 participants in a post-stroke research study and individuals co-ordinating stroke care attended a meeting at Newcastle University. The research physiotherapist who ran the study and other members of the research team presented the results of the trial. Attendees were encouraged to ask questions about the findings and there was discussion about how the results will be used to inform post-stroke care. The event was very well received and a number of emails were received following the event saying how much the attendees had enjoyed hearing about the outcomes of the study.

not yet known
Year(s) Of Engagement Activity 2012
 
Description Patient information day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 84 patients and their families atended an information day covering research and clincial needs. The Cohort study was mentioned and patients were invited to join the cohort.
The session was recorded and placed on YouTube

Questionnaires at end of session showed great support for such a day
Year(s) Of Engagement Activity 2010
 
Description Pecha Kucha presentation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact a CBAV PhD student, gave a Pecha Kucha presentation at the Yorkshire & North East Public Engagement event.

not known
Year(s) Of Engagement Activity 2011
 
Description Pronuclear paper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The publication of this paper in April 2010 generated a huge amount of media interest both nationally and inernationally.
Articles appeared in the following newspapers: The Times - page 15 http://tinyurl.com/y625ewj; Daily Mail - page 4 http://tinyurl.com/y5wr6x8; The Telegraph - page 1 http://tinyurl.com/y62t89o; The Guardian - page 1 http://tinyurl.com/y3u4g3m; The Express - page 7 http://tinyurl.com/yyanlh6; Financial Times - page 4 http://tinyurl.com/y6kw2qo; The Sun - page 4 http://tinyurl.com/y6f96cu (The Mirror - page 22 http://tinyurl.com/y6mm3fa

There was also extensive coverage on radio and television, most notably: The story led the Six O'clock news with a 5-minute slot; Sky News ran the story all night; Channel Four did a nice piece and a mention on the ITV news. There were slots on Radio 5 Live and the Today programme and mentions on
most BBC regional stations.

The story was also reported by the following international organisations: ABC News
CBC (Canada)
Globe and Mail (Canada)
MSNBC/ NBC
San Francisco Chronicle
BBC News
Daily Mail
Daily Telegraph
Financial Times
Guardian
Herald
Independent
Sun
Times
AFP (France)
Bloomberg
EFE (Spain)
Reuters
UPI
Xinhua (China)
ABC (Australia)
The Australian
Sydney Morning Herald
China Daily
People's Daily (China)
Spiegel (Germany)
Corriere della Sera (Italy)
La Repubblica (Italy)
Times of India



HFEA launched a public consultation into the ethics of pronuclear research in 2012.
Year(s) Of Engagement Activity 2010
 
Description Public Lecture - Newcastle 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Open public lecture entitled, 'Getting Old - An energy crisis in my cells' given by Professor Nils-Goran Larsson, Professor in Mitochondrial Genetics, Karolinska Institute, Sweden

Not known
Year(s) Of Engagement Activity 2009
 
Description RCUK Research Careers Case Study Survey 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact http://www.rcuk.ac.uk/researchcareers/value/Pages/valueresearchcareer.aspx
In May 2012 one of the CBAV postdoctoral researchers provided one of the case studies for the RCUK 'Value of Research Career' survey aimed at informing young people of the diversity of research careers available.

not known
Year(s) Of Engagement Activity 2012
 
Description Regional primary care lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact 90 primary care team members attended to listen to my lecture of physical activity and diabetes.

Broader comments and feedback about why and how physical activity may be used in primary care.
Year(s) Of Engagement Activity 2013
 
Description Response to Science comment article on mitochondrial transfer 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The article on the mitochondrial transfer technique sparked a media frenzy with articles appearing in many newspapers and magazines worldwide as well as extensive coverage on TV, radio and the internet. Below is a selection of items.
http://www.sciencemediacentre.org/tag/mitochondrialdna/
http://theconversation.com/viewpoints-the-promise-and-perils-of-three-parent-ivf-18402
http://www.bbc.co.uk/news/health-24158049
BBC News (quotes Robin LovellBadge and Doug Turnbull)
http://www.bbc.co.uk/news/health24158049
New Scientist (quotes Doug Turnbull)
http://www.newscientist.com/article/dn24230warningsoundedoverthreeparentivfsafety.
html#.UjwUrz82nm4
Times (quotes Robin LovellBadge and Doug Turnbull)
http://www.thetimes.co.uk/tto/health/news/article3874038.ece
Science AAAS (quotes Robin LovellBadge)
http://news.sciencemag.org/biology/2013/09/newcontroversyoverexperimentalivfmethod
BBC News (quotes Robin LovellBadge and Doug Turnbull)
http://www.bbc.co.uk/news/health24158049


The extensive media coverage has increased awareness of mitochondrial disease and we have received an increased number of enquiries and hits on our website.
Year(s) Of Engagement Activity 2014
 
Description SET for Britain 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Postdoctoral researchers and PhD students presented a poster about their research to members of both Houses of Parliament at the SET for Britain event on 12 March 2012. http://www.setforbritain.org.uk/

not known
Year(s) Of Engagement Activity 2012
 
Description The Salon Project 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Two of our researchers took part in the Salon Project Revisited at the Citizens' Theatre in Glasgow on Thursday 21 March 2013.
Dressed in full period costume they presented their research into age-related brain diseases, such as Parkinson's Disease. Using a weather chart as an analogy, they demonstrated the impact of neuronal loss on the substantia nigra, the region of the brain associated with Parkinson's Disease.
The Salon Project Revisited recreates the exclusive meetings at the heart of what was French society's golden age - an era of change, excess and inquiry. The evening begins with a transformation into full period costume by a coterie of dressers and make-up artists, before guests emerge into a mirrored impression of a 19th-century Parisian salon. As guests mingle, pioneers in their fields provoke discussion, speaking on subjects at the vanguard of 21st-century thought on science, politics, technology and the arts.
http://www.ncl.ac.uk/cbav/engagement/SalonProject.htm

The researchers received excellent feedback from the group, but we do not know of any specific impacts that have arisen since.
Year(s) Of Engagement Activity 2013
 
Description Website 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact A website (http://www.mitochondrialncg.nhs.uk) for both patient and health professional use. This is to increase awareness and knowledge of the disease and disseminate good practice.

This website is providing information for clinicians about referral and diagnostic options for patients not currently seen at a specialist centre. Likewise, patients are also able to find out about options, and also to gain knowledge and information about their condition.
Year(s) Of Engagement Activity 2009
 
Description Winner of I'm a Scientist get me out of here 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Schools
Results and Impact one of our postdoctoral researchers, won the competition in the Healthy Ageing Zone. The prize was £500 to be used to communicate the scientist's work.

the £500 prize money was used to organise an event at the Centre for Life Visitor Centre in Newcastle. Along with colleagues from the Centre for Brain Ageing & Vitality, the prize winner organised and ran a 'Meet the Scientist' stand offering visitors to the Centre for Life an opportunity to hear about the research going on at Newcastle University.
The day was a resounding success and the stand attracted dozens of interested children.

The following comments were received from the attraction engagement manager:

"Thank you so much for a really successful Meet the Scientist Event yesterday! We had over 800 visitors yesterday and I think lots of them found their way to your brain power zone! The
activities were great, from the sweetie DNA to real brain cells under the microscope, there seemed to be something for everyone. The best part of course was you and your team of
enthusiastic researchers! We're always thrilled when we can offer visitors the chance to talk to real scientists, as we know it's something that they really appreciate.
Please pass my thanks on to your colleagues too. I know that one or two of them mentioned having colleagues in other departments who would be interested in taking part in a Meet the Scientist Event, so please pass on my contact details too.
We love you to join us again sometime in the future. Just let us know which dates would suit you.
I thought you and your colleagues might also be interested in taking part Bright Club, where researchers take to the stage to talk about the funny side of their research.
http://www.life.org.uk/whats-on/events/bright-club-newcastle-3"
Year(s) Of Engagement Activity 2011
 
Description Young Public Sector Programme 2012 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact One of the CBAV PhD students took part in the programme, which is designed to stretch the minds, broaden the horizons and develop the communication skills of people in the early years of their public sector careers. http://www.youngprogramme.org/

The delegate felt much more confident and able to communicate her research to others after the experience of the workshop.
Year(s) Of Engagement Activity 2012
 
Description mHealth Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact I gave a keynote lecture on mHealth solutions and data from our recent mHealth tour

Connections with policy makers and healthcare providers.
Year(s) Of Engagement Activity 2013
URL http://www.idf.org/worlddiabetescongress