Advanced Clinical Cardiovascular MR Imaging and Spectroscopy at 7 Tesla

Lead Research Organisation: University of Oxford
Department Name: RDM Cardiovascular Medicine

Abstract

Magnetic Resonance Imaging (MRI) allows us to image the inside of the human body non-invasively. Pioneered in the brain this technique has become invaluable over the last 5-10 years for imaging the heart in the clinic. MRI scanners operate at a magnetic field strength of 1.5 Tesla. Increasing the magnetic field strength can provide higher image quality and we have pioneered the use of 3 Tesla scanners. The highest commercially available human field strength is 7 Tesla, which is our next step.

Imaging at higher field strength results in more signal, and thus, the images are obtained quicker, or with higher spatial resolution. The areas that we will develop are those that are limited by low SNR (signal-to-noise ratio) at 1.5 and 3 Tesla. These include imaging the coronary arteries and the energy-rich metabolites in the human heart. Coronary artery imaging is important as these vessels are critical to supplying blood to the heart (blockages cause ?heart attack?). The higher SNR of 7T will allow us to image the blood and walls of these vessels at higher resolution than has previously been possible with MRI enabling us to visualise small plaques and subtle damage. The metabolic condition of the heart is another important area of research where we in Oxford are world leaders. A technique called MRS (magnetic resonance spectroscopy) shows the biochemistry of the heart. Levels of phosphocreatine and adenosine triphosphate, which are essential energy-providing metabolites, can give an indication of damage even before functional changes become apparent. At 7T, the higher spatial resolution enables the MRS examination of small regions in the heart, equivalent to those presently required in clinical examination (this is impossible at lower field). Additional projects will build on these methods to look at oxygen supply, the degree of fibrous scar tissue, and the blood supply from small vessels in the heart.

Clinically these developments have the potential to transform MR imaging of cardiac metabolism, oxygenation, and coronary plaque biology from a niche research tool into a mainstream diagnostic measure that can treat the patient as an individual, enabling doctors to monitor the progress of a disease or the response to therapy over time. These techniques would contribute significantly to improving cardiovascular health and to relieving the burden of cardiovascular disease. Our plans are highly novel, and we would be the first site in the UK, and probably in Europe, developing cardiac MR at 7T.

Technical Summary

MR imaging of the cardiovascular system (CMR imaging) has made a huge clinical and scientific impact. Currently, CMR is performed at field strengths of either 1.5 or 3 Tesla (T). Here, CMR allows analysis of cardiac anatomy, function, viability and perfusion. CMR can offer much deeper insight into cardiac pathophysiology, as it is capable of providing accurate information about cardiac metabolism and oxygenation, coronary lumen anatomy and atherosclerotic plaque. However, these advanced CMR applications currently are severely limited by their low resolution and reproducibility. While 3T, compared to 1.5T, provides resolution gains in the right direction, these are insufficient. Our understanding of the major epidemic diseases in Cardiology, ischemic heart disease and heart failure, would benefit greatly from reliable and highly reproducible non-invasive characterisation of these advanced parameters. This would allow fundamentally novel insights into disease mechanisms and treatment effects. We aim to be at the leading edge of this new development by obtaining a high-field (7T) imaging system as a platform from which these highly desirable goals can be made a reality. In a collaborative effort (with local, national and international MR Physics partners), we will develop CMR methods at 7T, the first such effort in the UK (and probably in Europe). MR physics research will initially focus on coil design, SAR and B1 management, RF pulse optimisation, regional shimming. High resolution quantitative MR spectroscopy (MRS) will be developed, to measure cardiac high-energy phosphates and the novel parameters CK flux and free energy change, regionally resolved, with high reproducibility, making true metabolic imaging of the heart by MRS a reality for the first time. Clinical research applications will include ischemic heart disease, heart failure and hypertrophic cardiomyopathy. Coronary lumen and wall imaging will be developed with unprecedented resolution, allowing reliable non-invasive serial assessment of coronary artery disease in application studies. The BOLD effect is greatly enhanced at 7T, and we will develop robust imaging of myocardial oxygenation, allowing assessment of the interrelations amongst cardiac function, perfusion, oxygenation and metabolism in patients. Such a development has the potential to transform CMR imaging of cardiac metabolism, oxygenation, and coronary plaque from a niche research tool into a mainstream diagnostic measure that can treat the patient as an individual, enabling doctors to monitor the progress of a disease or the response to therapy. Such new MR techniques would contribute significantly to improving cardiovascular health and to relieving the burden of cardiovascular disease.

Publications

10 25 50

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Biasiolli L (2013) In-vivo quantitative T2 mapping of carotid arteries in atherosclerotic patients: segmentation and T2 measurement of plaque components. in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

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Burton RA (2012) Microscopic magnetic resonance imaging reveals high prevalence of third coronary artery in human and rabbit heart. in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

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Clarke WT (2016) Bloch-Siegert B1+-mapping for human cardiac (31) P-MRS at 7 Tesla. in Magnetic resonance in medicine

 
Description Cardiac T1 imaging steering group (Robson, Piechnik, Neubauer)
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
 
Description Stefan Neubauer is member of an international expert group on Simplifying Cardiovascular MR Pulse Sequence Terminology
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description 7T Programme Grant
Amount £1,304,942 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2011 
End 12/2015
 
Description Chris Rodgers (travel)
Amount £600 (GBP)
Organisation International Society for Magnetic Resonance in Medicine (ISMRM) 
Sector Charity/Non Profit
Country United States
Start 05/2012 
End 03/2013
 
Description Chris Rodgers Welcome Fellowship
Amount £1,200,000 (GBP)
Funding ID WT098436MA 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2012 
End 10/2013
 
Description NIHR - Oxford AL
Amount £240,000 (GBP)
Funding ID Cardiac Theme, DNP project 
Organisation Oxford University Hospitals NHS Foundation Trust 
Sector Public
Country United Kingdom
Start 04/2012 
End 04/2015
 
Description NIHR - Oxford LT
Amount £350,000 (GBP)
Funding ID Cardiac Imaging Theme, Tissue Characterisation LT 
Organisation Oxford University Hospitals NHS Foundation Trust 
Sector Public
Country United Kingdom
Start 04/2012 
End 04/2017
 
Description NIHR - Oxford SP
Amount £300,000 (GBP)
Funding ID Translational Phsiology Theme (Piechnik) 
Organisation Oxford University Hospitals NHS Foundation Trust 
Sector Public
Country United Kingdom
Start 04/2012 
End 04/2017
 
Description Will Clarke Studentship
Amount £50,000 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 10/2012 
End 10/2015
 
Description travel scholarship
Amount £5,000 (GBP)
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start 02/2012 
End 03/2012
 
Title 4D flow acquisition and analysis tools 
Description Dr Aaron Hess has developed a series of acquisition and analysis tools that he has distributed locally to support the development of 4D flow work in Oxford. Further these have been adopted by Siemens for international distribution. The work comes under a research agreement with Siemens. 
Type Of Material Improvements to research infrastructure 
Year Produced 2012 
Provided To Others? Yes  
Impact Presentation at recent 4D flow meeting (in Oxford). Distribution of code to Siemens and to a research group in San Francisco 
URL http://www.siemens.com
 
Title 4D flow acquisition and analysis tools 
Description Dr Aaron Hess has developed a series of acquisition and analysis tools that he has distributed locally to support the development of 4D flow work in Oxford. Further these have been adopted by Siemens for international distribution. the work comes under a research agreement with Siemens. 
Type Of Material Improvements to research infrastructure 
Year Produced 2012 
Provided To Others? Yes  
Impact Presentation at recent 4D flow meeting in Oxford. Distribution of code to Siemens and to a research group in San Francisco 
URL http://www.siemens.com
 
Title Cardiac imaging under Step 2.1 of the Siemens 7T environment 
Description This set of tools and techniques have been developed to allow us to use this scanner to acquire the required cardiac MRI data. The implementation of the Step 2.1 software was not well suited to this purpose and we have worked with Siemens to rectify the not inconsiderable set of problems. The goal of this work is to allow clinically trained research fellows to use this 7T MRI scanner as they might a "normal" clinical 1.5T scanner. 
Type Of Material Improvements to research infrastructure 
Year Produced 2013 
Provided To Others? Yes  
Impact Publication in this area is on a steep upward curve from a number of group who can now run these methods in a practical manner. Previously this was not the situation owing to the technical limitations of the scanner software. 
 
Title Multi-channel RF coil combination for spectroscopy and spectroscopy fitting tools 
Description Software tools that apply algorithms that we have published on to data acquired on MRI scanners. Specifically algorithms to combine the signals from multiple MRI coils for use in magnetic resonance spectroscopy. Further we have developed open source versions of the JMRUI (aka AMARES) in matlab which allows accurate and precise fitting of spectroscopy data. 
Type Of Material Improvements to research infrastructure 
Year Produced 2015 
Provided To Others? Yes  
Impact The method is used at several sites and they are publishing using data processed using this algorithm. 
 
Description Advanced navigator methods 
Organisation Massachusetts General Hospital
Country United States 
Sector Hospitals 
PI Contribution We have provided software and assistance to get these methods working and helped evaluate and debug the associated problems.
Collaborator Contribution MGH have provided low level software for controlling the MRI scanner in a low level manner. fMRIB have provided the clinical questions and expertise in spectroscopy of the brain.
Impact 22213578 22246720 24201013 24488204 24655149 24924772 24999293 25255945
Start Year 2013
 
Description Advanced navigator methods 
Organisation University of Oxford
Department Oxford Centre for Functional MRI of the Brain (FMRIB)
Country United Kingdom 
Sector Academic/University 
PI Contribution We have provided software and assistance to get these methods working and helped evaluate and debug the associated problems.
Collaborator Contribution MGH have provided low level software for controlling the MRI scanner in a low level manner. fMRIB have provided the clinical questions and expertise in spectroscopy of the brain.
Impact 22213578 22246720 24201013 24488204 24655149 24924772 24999293 25255945
Start Year 2013
 
Description Botnar KCL Coronary MRA 
Organisation King's College London
Department Cardiovascular Division
Country United Kingdom 
Sector Academic/University 
PI Contribution We provide the hardware (scanner and RF coils), technical know-how and access to normals controls and patients.
Collaborator Contribution Rene Rotnar is a world expert in coronary MRA with 20 years of experience. He provides expert guidance on how to optimise these methods for coronary MRA at 7T.
Impact No formal outputs as yet
Start Year 2011
 
Description Dr James Moon, London Heart Hospital 
Organisation University College London Hospital
Country United Kingdom 
Sector Public 
PI Contribution We provide the shortened shMOLLI sequence to support the work at the London Heart into Extra-cellular Volume fraction (ECVF) that they are doing on cardiac patients. The also use our method in assessing the T1 before MR contrast agents are used in patient groups with whom we hav elittle or no access
Collaborator Contribution Our partners have provided training in the use of the ECV method that we can use this approach in Oxford. Most valuably they have provided data on a number of interesting patient groups to whom the shMOLLI method has been found to offer new insights into disease. These insights have strengthened our understanding of what our new T1 mapping methods are showing.
Impact Large number of abstracts that are moving into full papers. Single breath-hold Vd(m) calculation as good as multi breath-hold technique in Equilibrium Contrast CMR Daniel Sado, Stefan K Piechnik, Matthew D Robson, Viviana Maestrini, Andrew Flett, Steven K White, Sanjay M Banypersad, James Moon Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):P262 (1 February 2012) Age and gender dependence of pre-contrast T1-relaxation times in normal human myocardium at 1.5T using ShMOLLI Stefan K Piechnik, Vanessa Ferreira, Adam J Lewandowski, Ntobeko Ntusi, Daniel Sado, Viviana Maestrini, Steven K White, Merzaka Lazdam, Rajarshi Banerjee, Mark B Hofman, James Moon, Stefan Neubauer, Paul Leeson, Matthew D Robson Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):P221 (1 February 2012) Histological validation of ShMOLLI equilibrium contrast CMR for the measurement of diffuse myocardial fibrosis Steven K White, Stefan K Piechnik, Stefan Neubauer, Matthew D Robson, James Moon Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):O111 (1 February 2012) Pre-contrast T1 mapping for detection of myocardial fibrosis in asymptomatic and symptomatic aortic stenosis Sacha Bull, Steven K White, Stefan K Piechnik, Andrew Flett, Vanessa Ferreira, Margaret Loudon, Jane M Francis, Stefan Neubauer, James Moon, Saul Myerson Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):P93 (1 February 2012) Pre-contrast ShMOLLI T1 mapping in cardiac AL amyloidosis Theodoros Karamitsos, Sanjay M Banypersad, Daniel Sado, Viviana Maestrini, Vanessa Ferreira, Stefan K Piechnik, Matthew D Robson, Philip N Hawkins, Stefan Neubauer, James Moon Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):O76 (1 February 2012)
Start Year 2010
 
Description Minnesota cardiac function and coil collaboration 
Organisation University of Minnesota
Department Department of Biomedical Engineering
Country United States 
Sector Academic/University 
PI Contribution We have provided the clinical cardiac expertise to build and design an experiment to test whether 7Tesla MRI can deliver good image quality and accurate clinical metrics versus previous methods. Our MRI systems have been used in this comparison. We have provided the clinical cardiac perspective to them regarding what is necessary from 7T to assist clinical decision making.
Collaborator Contribution Technological benefits of their coil technology, and access to their software tools is of huge value to us. Additional conversations and site visits have moved forward our technology and understanding of these technologies immeasurably.
Impact One Oxford scicentist won a Royal Society Award to work in Minnesota on the back of this collaboration, and there have been over 10 visits between the two sites over the last year. Additionally we have generated 4 peer reviewed publications in highly respected journals. 1: Keith GA, Rodgers CT, Hess AT, Snyder CJ, Vaughan JT, Robson MD. Automated tuning of an eight-channel cardiac transceive array at 7 Tesla using piezoelectric actuators. Magn Reson Med. 2014 Jul 1. doi: 10.1002/mrm.25356. [Epub ahead of print] PubMed PMID: 24986525. 2: Rodgers CT, Clarke WT, Snyder C, Vaughan JT, Neubauer S, Robson MD. Human cardiac 31P magnetic resonance spectroscopy at 7 Tesla. Magn Reson Med. 2014 Aug;72(2):304-15. doi: 10.1002/mrm.24922. Epub 2013 Sep 4. PubMed PMID: 24006267; PubMed Central PMCID: PMC4106879. 3: Rodgers CT, Piechnik SK, Delabarre LJ, Van de Moortele PF, Snyder CJ, Neubauer S, Robson MD, Vaughan JT. Inversion recovery at 7 T in the human myocardium: measurement of T(1), inversion efficiency and B(1) (+). Magn Reson Med. 2013 Oct;70(4):1038-46. doi: 10.1002/mrm.24548. Epub 2012 Nov 29. PubMed PMID: 23197329; PubMed Central PMCID: PMC4134266. 4: Suttie JJ, Delabarre L, Pitcher A, van de Moortele PF, Dass S, Snyder CJ, Francis JM, Metzger GJ, Weale P, Ugurbil K, Neubauer S, Robson M, Vaughan T. 7 Tesla (T) human cardiovascular magnetic resonance imaging using FLASH and SSFP to assess cardiac function: validation against 1.5 T and 3 T. NMR Biomed. 2012 Jan;25(1):27-34. doi: 10.1002/nbm.1708. Epub 2011 Jul 19. PubMed PMID: 21774009; PubMed Central PMCID: PMC3440016.
Start Year 2009
 
Description Nijmegen 31P collaboration 
Organisation Radboud University Nijmegen Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution We have provided some software for the optimal combination of Magnetic Resonance Spectroscopy data when acquired with a multi-channel array coil. Work that we have pioneered and are experts at.
Collaborator Contribution We provide software to them, they use the methods and provide feedback on its utility to us. The Nijmegen group are very experienced with MRS and 31P so these conversations are very valuable.
Impact Internal testing reports and improved documentation.
Start Year 2013
 
Description Parallel Transmission between KCL and Oxford 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Starting at the beginning. This is a project between KCL, the Oxford cardiac MRI group and the Oxford brain MRI group. Each party supplies a post-doc. Oxford supply the MRI scanner. The Oxford cardiac MRI group provide the relevant MRI coil. KCL have some a priori Parallel Transmission expertise. The 3 post-docs have had dedicated MRI 7T scanner time (4 hours/week). So, I provide a 7T scanner, a small amount of my time, a post-doc (typically 2 days a week) and the use of my cardiac RF coil.
Collaborator Contribution KCL provide some prior experience of Parallel transmission and software tools in this area. In addition to the time that their post-doc engages in they have expertise to lend from senior scientists which has proved helpful at times.
Impact 2 publications are expected, one has been written but not yet submitted, the second is in an earlier formative phase.
Start Year 2013
 
Description Paul Bottomley 
Organisation Johns Hopkins University
Country United States 
Sector Academic/University 
PI Contribution We provide data and the ability to collect data on our 7Tesla MRI scanner
Collaborator Contribution Paul Bottomley is widely respected as the world expert on cardiac 31P spectroscopy (from a technical perspective), and provides advice and expert guidance on technical elements of these methods. Further he will host one of our researchers as part of a training programme.
Impact None as yet
Start Year 2010
 
Description University of Minnesota 
Organisation University of Minnesota
Department Centre for Magnetic Resonance Research
Country United States 
Sector Academic/University 
PI Contribution We have worked at their site and taught them how to collect high quality cardiac MRI images. We have assisted them in writing grant applications and helped educate them in the practical utility in cardiology of ultra-high field MRI of the heart. Included in this were a series of visits from which we have published 4 papers. Most recently one of our research fellows visited their site to collect data on 6 subject for one of their grant applications that will also help the collaboration from their end. This recent visit will result in an abstract and hopefully further papers in this area.
Collaborator Contribution The group at Minnesota have supplied components and assisted us in building TEM RF coil systems that are essential for imaging the human heart at 7 tesla and are not commercially available. They have worked with us on some novel designs for coil tuning from which we have published joint abstracts.
Impact 1: Keith GA, Rodgers CT, Hess AT, Snyder CJ, Vaughan JT, Robson MD. Automated tuning of an eight-channel cardiac transceive array at 7 Tesla using piezoelectric actuators. Magn Reson Med. 2014 Jul 1. doi: 10.1002/mrm.25356. [Epub ahead of print] PubMed PMID: 24986525. 2: Rodgers CT, Clarke WT, Snyder C, Vaughan JT, Neubauer S, Robson MD. Human cardiac 31P magnetic resonance spectroscopy at 7 Tesla. Magn Reson Med. 2014 Aug;72(2):304-15. doi: 10.1002/mrm.24922. Epub 2013 Sep 4. PubMed PMID: 24006267; PubMed Central PMCID: PMC4106879. 3: Rodgers CT, Piechnik SK, Delabarre LJ, Van de Moortele PF, Snyder CJ, Neubauer S, Robson MD, Vaughan JT. Inversion recovery at 7 T in the human myocardium: measurement of T(1), inversion efficiency and B(1) (+). Magn Reson Med. 2013 Oct;70(4):1038-46. doi: 10.1002/mrm.24548. Epub 2012 Nov 29. PubMed PMID: 23197329; PubMed Central PMCID: PMC4134266. 4: Suttie JJ, Delabarre L, Pitcher A, van de Moortele PF, Dass S, Snyder CJ, Francis JM, Metzger GJ, Weale P, Ugurbil K, Neubauer S, Robson M, Vaughan T. 7 Tesla (T) human cardiovascular magnetic resonance imaging using FLASH and SSFP to assess cardiac function: validation against 1.5 T and 3 T. NMR Biomed. 2012 Jan;25(1):27-34. doi: 10.1002/nbm.1708. Epub 2011 Jul 19. PubMed PMID: 21774009; PubMed Central PMCID: PMC3440016.
Start Year 2010
 
Description Vienna 31P collaboration 
Organisation University of Vienna
Country Austria 
Sector Academic/University 
PI Contribution We have provided software to allow them to combined Magnetic Resonance Spectroscopy data from a multi-coil system.
Collaborator Contribution Our partners have installed and evaluated the software and provided feedback. This is part of an ongoing conversation that we expect will result in the adoption of these methods by the MRI equipment manufacturers.
Impact Internal documentation, bug repors and feedback, but no external outputs.
Start Year 2014
 
Description fMRIB 7T collaboration 
Organisation John Radcliffe Hospital
Department Centre for Functional MRI of the Brain (fMRI)
Country United Kingdom 
Sector Hospitals 
PI Contribution We have developed the use of 7T scanning in collaboration with fMRIB. Our research team provide financial support for parts of the system and direct technical support for specific aspects of the RF system.
Collaborator Contribution fMRIB provide local infrasructure to host the equipment. Further they provide framework for safety, training and ethics which helps us use this equipment most efficiently. There is an area of common ground between the research groups on various aspects of MRI physics where we assist each other.
Impact 22498328 20110375 18093924 19603408 18093924 17406613 17023184 17000119 16381189 16271482 16192375 16120793 15340158
Start Year 2007
 
Title Rapid Imaging Assessment of the Liver 
Description By combining 3 imaging methods we can accurately stage liver disease using MRI. This technique can replace the use of an invasive biopsy which saves money and provides a better patient experience. 
IP Reference WO2013088149 
Protection Patent application published
Year Protection Granted 2011
Licensed Commercial In Confidence
Impact University spin-off company being formed
 
Title T1 mapping in abdominal visceral organs 
Description T1 mapping of the visceral organs (including the liver) is one important part of our liver imaging toolkit. This method uses an approach that we patented in the heart but applies it to the liver. 
IP Reference WO2013088151 
Protection Patent application published
Year Protection Granted 2011
Licensed Commercial In Confidence
Impact University spin-off company being formed
 
Title LiverMultiscan 
Description The LiverMultiscan method (described in the patents describes above) is a method for diagnosing liver disease. This work was supported by a BHF fellow. 
Type Diagnostic Tool - Imaging
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2010
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Company spun out (Perspectum Diagnostics Ltd). Successfully raised seed fund capital (~£500k). Won "Technology Strategy Board funding" (~£1.2m). 
 
Title shMOLLI method to Siemens 
Description We developed a T1 mapping method that we have used our 3T and 1.5T systems to validate. These methods have been taken on by Siemens Healthcare and have been incorporated into their clinical product (presently as a works-in-progress package, but this is likely to become part of their mainstream product). 
Type Diagnostic Tool - Imaging
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact The diagnostic imaging method that we have developed allows images to be collected faster that results in more reliable image quality. Further more we generate quantitative maps of relaxation parameters from these measurements in real-time which has been found to be a very useful tool in the clinic and appears to improve diagnosis on various clinical patient groups. 
 
Description Imaging sciences presentation day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact ~200 scientists from across the university and beyond attended this meeting which was designed to show what imaging methods are available.

Several MSc candidates contacted us about doing projects within our group.
Year(s) Of Engagement Activity 2010
 
Description Invited presentation at Imaging Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact 150 researchers and students working in the general field of imaging attended the workshop.

http://www.imaging.ox.ac.uk/activities/annual-festival/imagefest12/programme

Useful subsequent e-mail correspondence with a group who are interested in developing some clever processing methods on our 3D cardiac ex-vivo datasets. ....@inria.fr
Year(s) Of Engagement Activity 2012
 
Description Liz CSO Presentation 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presentation by one of our group on MRI cardiac imaging of an acute imaging centre to the CSO of the NHS. 20 minute presentaiton.

Talk was well received.
Year(s) Of Engagement Activity 2012
 
Description Liz MRC/SRC Summerville 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Presentation to a general academic College audience on the science that we do

Talk was well received
Year(s) Of Engagement Activity 2012
 
Description MDR Imaging Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact 200 people attended an imaging festival meeting and learned about what we do.

The talk was well received and we followed up contact from a group who are keen to use our ex-vivo diffusion data.
Year(s) Of Engagement Activity 2012
 
Description Oxford BioMedical Imaging Festival Organisation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact This is an annual meeting that I co-organise. It is often over subscribed (200 limit) and provides an excellent 1 day education forum for experts in oxford university to present and inspire with what they are doing. This extends over a large range of imaging modalities (microscopy in all its forms, MRI , ultrasound, x-ray, etc.) and multiple sample systems (from single atom up to whole people typically).

I have organised, presented and chaired sessions every year.

Lots of cross discipline conversations. For example we spawned a potential project relating to safety with a scientist who is investigating the use of magnetic micro-bubbles for local treatment targeting. Every year lots of cross-pollination occurs.
Year(s) Of Engagement Activity 2012,2013,2014,2015
URL http://www.imaging.ox.ac.uk/2015-imaging-festival/index.html
 
Description Oxford Open-Doors event. 7T show and tell 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact We demonstrated how 7 tesla scanners can image the brain and imaged thought processes in real time. This unsurprisingly stimulated considerable discussion and interest. There were 3 audience groups (of around 20) and each of them posed some interesting questions that will certainly affect how we write our ethics and volunteer forms in the future.

No specific interactions except a real "feel good" factor for the team running the demos.
Year(s) Of Engagement Activity 2014
URL http://www.oxfordopendoors.org.uk/
 
Description Summer School visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact 45 people visited who were involved in a summer school activities in Oxford. They spend 2 hours with us and we performed live demonstrations of MRI scanning on 2 different MRI systems, and discussed the usage of MRI from a clinical perspective.

We received very positive feedback both at the time and subsequent to the event from several of the attendees (actually it was pretty nice).
Year(s) Of Engagement Activity 2012
 
Description Summer School visit MDR 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact We hosted a site visit for a Summer School that focused on cardiac engineering. http://mpss.iop.org/index.html

This involved a 2 hour visit to our site where we performed live demonstrations on MRI scanning and presented talks on what the method could offer clinically.

The talks and presentations were very well received, and our scores in the end of course assessment were at the 80% level, which we were told was very high.
Year(s) Of Engagement Activity 2012