Mathematical modelling of mechanisms of multidrug resistance

Lead Research Organisation: University of Southampton
Department Name: School of Mathematics

Abstract

Cancer and malaria are two diseases, amongst many, that frequently become multidrug resistant and this can have a major impact on the survival rates from these diseases. The goal of this work is to investigate mechanisms for the development of multidrug resistance by using a combined experimental and mathematical modelling approach.

Technical Summary

The proposed research will investigate biophysical mechanisms for multidrug resistance by combining an in vivo experimental approach and a mathematical modelling approach. Mathematical models for drug transport via membrane transporters (e.g. PGP) will be developed alongside alternative potential mechanisms which rely on changes to the pH and membrane potential of the cell. These models will be analysed and assessed in comparison to the experimental results from this programme and other published data.

Publications

10 25 50
 
Description Cyril Rauch 
Organisation University of Nottingham
Department School of Veterinary Medicine and Science Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution This grant has funded a collaboration between Cyril Rauch (Veterinary Science, Nottingham) to investigate Multi-Drug resistance. We have worked on trying to formulate mathematical models of various hypotheses for this phenomenon.
Collaborator Contribution We have jointly authored a publication and hope to write others on the subject of multidrug resistance in the future.
Impact This has resulted in a paper (at preprint stage) on ``Evaluating the vacuum cleaner hypothesis of multidrug resistance''.
Start Year 2008