Role of thyroid hormone receptors in osteoclast differentiation and function

Lead Research Organisation: Imperial College London
Department Name: Dept of Medicine

Abstract

Osteoporosis is a major health priority affecting half of women and one in five men over 50 and costing the NHS #1.7 billion a year. Thyrotoxicosis is an established cause of osteoporotic fracture but the underlying mechanism of bone loss has not been determined. Our recent studies, however, indicate that thyroid hormone receptor alpha (TRalpha) has a critical role in skeletal development, acquisition and maintenance of adult bone and thyrotoxic bone loss. Moreover, our studies suggest that TRalpha has an important role in regulating the activity of bone resorbing osteoclasts. Although the mechanism is unknown these studies identify TRalpha as a potential new drug target for the treatment and prevention of osteoporosis. Importantly, the therapeutic potential of TR-isofom specific compounds has already been demonstrated in patients with for high cholesterol. In the proposed studies Dr Bassett and Professor Williams at the MRC Clinical Sciences Centre, Imperial College London, will characterise the actions of T3 in osteoclasts and their subsequent effects on bone structure and strength. These studies are critical and timely as it is essential that the molecular mechanism of thyrotoxic bone loss is defined, before new drugs, acting on TRalpha are developed for the treatment of osteoporosis.

Technical Summary

Aims: Thyrotoxicosis is an established cause of osteoporosis and fracture but the mechanism of thyrotoxic bone loss is controversial as it is unclear whether thyroid hormone (T3) excess or TSH deficiency mediates bone loss. Although T3 receptors (TRs) and the TSH receptor (TSHR) are expressed in bone cells, our recent studies of TR and TSHR deficiency have directly addressed this controversy and established that the actions of TRs predominate. Furthermore, the skeletal phenotypes of TR deficient mice are characterised by abnormal osteoclastic bone resorption.

I hypothesis that accelerated bone loss in hyperthyroidism is mediated by the direct actions of thyroid hormone (T3) in osteoclasts.

Objectives: To address this hypothesis, I will:
1) Determine if T3 acts directly via TRs expressed in osteoclasts.
2) Determine the mechanism of T3-action in osteoclasts.

Experimental Design and Methodology:
The skeletal effects of TR deficiency restricted to the osteoclast-lineage will be determined in mice using cre-lox technology. Skeletal development in juveniles and bone structure in adult mice will be determined by light, confocal and back-scattered electron scanning electron microscopy. Bone strength will be determined by destructive three-point bending and compression studies. The molecular mechanism of T3-induced bone loss will be determined using gene expression profiling and quantitative RT-PCR analysis in primary cultures of wild type and TR-deficient osteoclasts. The role of TRs in osteoblastic regulation of osteoclast differentiation will be investigated in co-cultures of wild-type and TR-deficient calvarial osteoblasts and splenic osteoclast progenitor cells.

Scientific Opportunities: The project arises from our finding that TRalpha deficiency results in increased bone mass and reduced osteoclast activity, whereas TRbeta deficiency causes osteoporosis secondary to increased osteoclastic bone resorption. Although hyperthyroidism increases bone loss, the mechanisms are unclear and reports of TR expression and T3 responsiveness in osteoclasts are conflicting. It is now essential to demonstrate whether T3 regulates osteoclast activity directly.

Medical Opportunities: Osteoporotic fractures cost the NHS #1.7 billion each year. Our preliminary data identify TRalpha as a potential drug target for the prevention and treatment of osteoporosis. These studies will determine the mechanism of T3 action in bone and generate in vitro and in vivo models in which to evaluate the pharmacological manipulation of TRs.

Publications

10 25 50
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Bassett JH (2012) Quantitative X-ray imaging of rodent bone by Faxitron. in Methods in molecular biology (Clifton, N.J.)

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Bassett JH (2010) Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts. in Proceedings of the National Academy of Sciences of the United States of America

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Bassett JH (2009) The skeletal phenotypes of TRalpha and TRbeta mutant mice. in Journal of molecular endocrinology

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Combs CE (2011) Thyroid hormones and bone development. in Minerva endocrinologica

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Esapa CT (2012) Bone Mineral Content and Density. in Current protocols in mouse biology

 
Description ARUK Clinical Research Fellowship
Amount £251,784 (GBP)
Organisation Versus Arthritis 
Start 10/2011 
End 09/2014
 
Description Horizon 2020
Amount € 6,000,000 (EUR)
Funding ID THYRAGE-666869 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 12/2015 
End 11/2021
 
Description MRC
Amount £887,000 (GBP)
Funding ID MR/N01121X/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2016 
End 04/2020
 
Description Society for Endocrinology Early Career Grant
Amount £10,000 (GBP)
Organisation Society for Endocrinology 
Sector Learned Society
Country United Kingdom
Start 01/2013 
End 12/2013
 
Description Wellcome Trust Investigator Award
Amount £1,896,620 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Senior Investigator Award
Sector Private
Country United Kingdom
Start 10/2016 
End 09/2021
 
Description Wellcome Trust Stategic Award
Amount £2,824,022 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2014 
End 01/2019
 
Description Wellcome Trust project Grant
Amount £475,778 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2012 
End 03/2015
 
Title In vivo determination of osteoclast activity 
Description Endosteal and trabecular bone surface activities are quantified in high resolution back-scattered electron scanning electron microscopy images. The fraction of bone surface showing osteoclastic resorption is determined using bespoke imageJ software. 
Type Of Material Technology assay or reagent 
Year Produced 2009 
Provided To Others? Yes  
Impact This new methodology was presented at the European Calcified Tissue Society Advanced Training Course in Aberdeen 
 
Title Quantitative Faxitron analysis of the skeleton 
Description We purchased a Faxitron MX20 Digital X-ray unit and have developed a novel and rapid method to determine skeletal morphometric parameters and bone mineral content at a resolution of 10 micron. 
Type Of Material Technology assay or reagent 
Year Produced 2009 
Provided To Others? Yes  
Impact 1) We have used this novel methodology for skeletal analysis of many genetically modified mice generated by orselves and others. Furthermore, this method has been used in pilot studies to screen 100 unselected knockout mice from the International Knockout Mouse Consortium (IKMC) (see manuscript below) 2) This new methodology was presented at the European Calcified Tissue Society Advanced Training Course in Aberdeen 2) This method has been included in the 2nd edition of "Bone reseach Protocols" JHD Bassett, A van der Spek, AI Gogakos, GR Williams (2012) Quantitative X-ray imaging of rodent bone in "Methods in Molecular Medicine; Bone Research Protocols 2nd Edition" MH Helfrich and SH Ralston Eds (Humana Press. New York) 2011 (In Press) 3) This Quantitative Faxitron analysis has been used in 3 published articles and in 3 currently submitted manuscripts a) JHD Bassett, A. Boyde, PGT Howell, RH Bassett, TM Galliford, M Archanco, H Evans, MA Lawson, P Croucher, D St.Germain, VA Galton, GR Williams (2010) Optimal bone mineralization and strength requires the type 2 iodothyronine deiodinase in osteoblasts. Proc. Natl. Acad. Sci. USA 107:7604-7609 (PMID: 21088133) b) M Hu, JHD Bassett, L Danks, PGT Howell, K Xu, E Spanoudakis, I Kotsianidis, A Boyde, GR Williams, N Horwood, IAG Roberts, A Karadimitris (2011) Activated invariant NKT cells regulate osteoclast development and function. J. Immunol 186: 2910-2917 (PMID:21278350) c) CT Esapa, T Hough, S Testori, R Head, E Crane, C Chan, E McNally, A Carr, JHD Bassett, G Williams, M Brown, P Croucher, MA Nesbit, SDM Brown, R Cox, M Cheeseman, RV Thakker (2011) A Mouse Model for Spondyloepiphyseal Dysplasia Congenita with Secondary Osteoarthritis due to a Col2a1 Mutation. Journal of Bone and Mineral Research (DOI: 10.1002/jbmr.547) (PMID:22028304) d) JHD Bassett, A Boyd, H Evans, P Croucher, X Sun, S Xu, Y Murata, GR Williams. Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function. In revision at ENDOCRINOLOGY. e) A Karunaratne, CT Esapa, J Hiller, A Boyde, R Head, JHD Bassett, NJ Terrill, GR Williams, MA Brown, P Croucher, SDM Brown, RD Cox, AH Barber, RV Thakker, HS Gupta. Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging. Revised Mauscript at J Bone Miner Res. f) JHD Bassett, A Gogakos, JK White, H Evans, RM Jacques, AH van der Spek, Sanger Mouse Genetics Project, R Ramirez-Solis, E Ryde2, DSunter, A Boyde, MJ Campbell, PI Croucher, GR Williams. Phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. Submitted to SCIENCE. 
URL http://europepmc.org/abstract/MED/21088133
 
Title Skeletal mechanical testing 
Description We purchased an Instron 5543 load frame and have developed bespoke fittings to facilitate 3 point bending, compression and torsional analysis of specimens from in vivo models of skeletal disease. We have also designed custom software to calculate standard material strength parameters in these samples. 
Type Of Material Improvements to research infrastructure 
Year Produced 2009 
Provided To Others? Yes  
Impact Development of this new methodology has facilitated collaboration with the Kennedy Institute of Rheumatology and the detailed analysis of multiple in vivo models of fracture healing. Furthermore, we are using this methodology in a pilot project with the Sanger Institute screening 100 consecutive lines, from the Knockout Mouse Project. 
 
Title Origin of Bone and Cartilage Disease website and data base 
Description Our expertese in mouse skeletal phenotyping, that resulted from MRC funding, led to a wellcome Trust Strategic Award to persorm skeletal phenotyping in mice generated by the International Knockout Mouse Consortium 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? Yes  
Impact Acccess to comprehensive skeletal phenotype data for IKMC mice 
URL http://www.boneandcartilage.com/
 
Description Analysis of skeletal pehenoytype in PYY-KO mice 
Organisation University College London
Department Division of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Detailed skeletal analysis of the developing and adult PYY-KO mouse
Collaborator Contribution Dr Rachel Batterham generated the PYY-KO mouse
Impact Oral presentation at British Endocrine Societies Annual Meeting. OC4.8
Start Year 2012
 
Description Anita Boelen: Role of the type 3 deiodinase in macrophage activity 
Organisation Academic Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution Generation of the Rosa26/D3 mouse line and cross with LysM-Cre (monocyte/macrophage lineage specific)
Collaborator Contribution Established S. pneumoniae infection protocol
Impact Experiments in progress
Start Year 2011
 
Description Control of macrophage multinucleation in health and disease 
Organisation Imperial College London
Department Faculty of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Generation of genetically modified mice, provocation models in genetically modified mice and skeletal phenotyping of genetically modified mice Primary cell culture
Collaborator Contribution Primary culture and RNAseq analysis
Impact MRC Research grant: Control of macrophage multinucleation in health and disease (MR/N01121X/1) £887,000 Publication: H Kang, A Kerloc'h, M Rotival, X Xu, Q Zhang, Z D'Souza, M Kim, JC Scholz, J-H Ko, PK Srivastava, JR Genzen, W Cui, TJ Aitman, L Game, JE Melvin, A Hanidu, J Dimock, J Zheng, D Souza, A Behera, G Nabozny, HT Cook, JHD Bassett, GR Williams, J Li, A Vignery, E Petretto, J Behmoaras (2014) Kcnn4 is a new regulator of macrophage multinucleation in bone homeostasis and inflammatory disease. Cell Reports 8:1210-24. (PMID: 25131209)
Start Year 2015
 
Description Heike Heuer analysis of Oatp1c1KO mice 
Organisation Leibniz Association
Department Leibniz Institute for Age Research
Country Germany 
Sector Public 
PI Contribution Skeletal analysis of knockout mice
Collaborator Contribution generation of knockout mice
Impact None yet
Start Year 2012
 
Description Lutz Schomburg: Skeletal analysis of Selenoprotein P (SEPP1) defficient mice 
Organisation Charité - University of Medicine Berlin
Department Institute of Experimental Endocrinology
Country Germany 
Sector Academic/University 
PI Contribution Detailed skeletal phenotyping
Collaborator Contribution Generation of SEPP1 knockout mice
Impact Studies in progress
Start Year 2011
 
Description Peter Croucher Mellanby Centre for Bone Research 
Organisation University of Sheffield
Department Sheffield Medical School
Country United Kingdom 
Sector Hospitals 
PI Contribution 1) Professor Crouchers group has performed skletal micro CT alaysis on generated genetically modified mice generated by our group 2) We have performed x-ray microradiography and biomechanical testing on mice generated in Professor Crouchers laboratory 3) We have jointly analysed the skeletal phenotype of a series of genetically modified mice
Collaborator Contribution The collaboration allows us to combine state of the art skeletal phenotyping methods
Impact 1) ARC Programme Grant (3344) Under consideration Co-Applicants: Croucher, Bassett, Williams Programme Title: New gene targets for anabolic therapy in osteoporosis. 2) Welcome Trust Project Grant (94134) Awarded Co-Applicants: Williams, Bassett, Croucher Project Title: Characterization of low bone mass phenotypes in 3 knockout mouse strains from the Wellcome Trust Sanger Institute high throughput gene targeting pipeline. 3) Bassett et al 2010 ) Optimal bone mineralization and strength requires the type 2 iodothyronine deiodinase in osteoblasts. PNAS 107:7604-7609 (PMID: 21088133) 4) JHD Bassett, A Boyd, H Evans, P Croucher, X Sun, S Xu, Y Murata, GR Williams. Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function. In revision at ENDOCRINOLOGY. 5) JHD Bassett, A Gogakos, JK White, H Evans, RM Jacques, AH van der Spek, Sanger Mouse Genetics Project, R Ramirez-Solis, E Ryde2, DSunter, A Boyde, MJ Campbell, PI Croucher, GR Williams. Phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. Submitted to SCIENCE.
Start Year 2009
 
Description Raj Thakker, Academic Endocrine Unit, Nuffield Department of Clinical Medicine 
Organisation University of Oxford
Department Nuffield Department of Clinical Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution We have performed state of the are skeletal phenotyping on 3 different mouse models of skeletal disease. these include digital x-ray microradiogtraphy, electron microscopy, dyanmic and static histomorphometry and biomechanical analysis
Collaborator Contribution In collaboration with Professor Raj Thakker we have analysed a number of genetically modified mice with severe skeletal phenotypes.
Impact 1) Esapa C, Hough T, Testori S, Head R, Crane E, Chan C, Evans H, Bassett J, Tylzanowski P, McNally E, Carr A, Boyde A, Howell P, Clark A, Williams G, Brown M, Croucher P, Nesbit M, Brown S, Cox R, Cheeseman M, Thakker R. (2011) A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation. J Bone Miner Res. (doi: 10.1002/jbmr.547) (PMID:22028304) 2) A Karunaratne, CT Esapa, J Hiller, A Boyde, R Head, JHD Bassett, NJ Terrill, GR Williams, MA Brown, P Croucher, SDM Brown, RD Cox, AH Barber, RV Thakker, HS Gupta. Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging. Revised Mauscript at J Bone Miner Res.
Start Year 2009
 
Description Rrole of local thyroid hormone action in age related chronic disease 
Organisation Hungarian Academy of Sciences (MTA)
Department Department of Endocrine Neurobiology
Country Czech Republic 
Sector Academic/University 
PI Contribution Generation of essential genetically modified mouse models Performing provocation models of chronic skeletal disease Skeletal phenotyping Primary bone cell culture
Collaborator Contribution Human cohort studies Studies in neurological degenerative disease Studies in sarcopaenin and muscular degenerative disease
Impact 5 year European Commission Horizon 2020 grant for €6 million (THYRAGE-666869) Title: Resetting the THYRoid axis for prevention of AGE-related diseases and co-morbidities
Start Year 2014
 
Description Rrole of local thyroid hormone action in age related chronic disease 
Organisation Leiden University
Country Netherlands 
Sector Academic/University 
PI Contribution Generation of essential genetically modified mouse models Performing provocation models of chronic skeletal disease Skeletal phenotyping Primary bone cell culture
Collaborator Contribution Human cohort studies Studies in neurological degenerative disease Studies in sarcopaenin and muscular degenerative disease
Impact 5 year European Commission Horizon 2020 grant for €6 million (THYRAGE-666869) Title: Resetting the THYRoid axis for prevention of AGE-related diseases and co-morbidities
Start Year 2014
 
Description Rrole of local thyroid hormone action in age related chronic disease 
Organisation National Center for Scientific Research (Centre National de la Recherche Scientifique CNRS)
Department Centre for Developmental Biology
Country France 
Sector Charity/Non Profit 
PI Contribution Generation of essential genetically modified mouse models Performing provocation models of chronic skeletal disease Skeletal phenotyping Primary bone cell culture
Collaborator Contribution Human cohort studies Studies in neurological degenerative disease Studies in sarcopaenin and muscular degenerative disease
Impact 5 year European Commission Horizon 2020 grant for €6 million (THYRAGE-666869) Title: Resetting the THYRoid axis for prevention of AGE-related diseases and co-morbidities
Start Year 2014
 
Description Rrole of local thyroid hormone action in age related chronic disease 
Organisation Second University of Naples
Department Dipartimento di Medicina Clinica e Chirurgia
Country Italy 
Sector Academic/University 
PI Contribution Generation of essential genetically modified mouse models Performing provocation models of chronic skeletal disease Skeletal phenotyping Primary bone cell culture
Collaborator Contribution Human cohort studies Studies in neurological degenerative disease Studies in sarcopaenin and muscular degenerative disease
Impact 5 year European Commission Horizon 2020 grant for €6 million (THYRAGE-666869) Title: Resetting the THYRoid axis for prevention of AGE-related diseases and co-morbidities
Start Year 2014
 
Description Ulrich Schweizer Skeletal analysis of SBP2-KI mice 
Organisation University of Bonn
Country Germany 
Sector Academic/University 
PI Contribution We will analyse the developmental and adult skeletal phenotype of mice lacking selenoproteins. The mice have a point mutation in SBP2 preventing use of the aminoacid selenocystine.
Collaborator Contribution They generated the mutant mice
Impact None yet
Start Year 2013
 
Description Wellcome Trust Sanger Institute Mouse Genetics Programme skeletal phenotype screening 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution We have analysed the skeletal phenotype of more than 100 consecutive knockout lines from the WRSI Mouse genetics Programme
Collaborator Contribution identified that deletion of 6 genes not previously implicated in bone biology results in profound abnormalities of the skeleton
Impact 2) Welcome Trust Project Grant (94134) Awarded Co-Applicants: Williams, Bassett, Croucher Project Title: Characterization of low bone mass phenotypes in 3 knockout mouse strains from the Wellcome Trust Sanger Institute high throughput gene targeting pipeline. 2) JHD Bassett, A Gogakos, JK White, H Evans, RM Jacques, A van der Spek, , R Ramirez-Solis, E Ryder, D Sunter, A Boyde, MJ Campbell, PI Croucher, GR Williams (2012) Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS Genetics, e1002858 (PMID:22876197)
Start Year 2009
 
Description 60th British Thyroid Association Meeting, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Invited symposium speaker Title: "Thyroid hormone and the skeleton". Intensive discussion.


75% of the audience were heath care professionsional. This clinical symposium highlighted the current understanding of thyroid hormone actions in cancer, the skeleton and appetite.
Year(s) Of Engagement Activity 2010
 
Description Advanced Medicine Course, Royal College of Physicians, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation keynote/invited speaker
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Active discussion and improved understanding

Invitations to futher engagement events
Year(s) Of Engagement Activity 2014
URL https://www.rcplondon.ac.uk/events/advanced-medicine
 
Description Association for Multiple Endocrine Neoplasia Disorders 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Hammersmith Hospital Multidisciplinary Symposium
Association for Multiple Endocrine Neoplasia Disorders Group meeting with 20 attendees
Title "The Challenges of thyroid disease in MEN syndromes"

Raise profile amongst patient groups
Year(s) Of Engagement Activity 2009
 
Description British Endocrine Societes Annual Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact More than 200 people attended the session which resulted in agreat deal of interest in the area

increased awarness of thyroid hormone action and its critical role in multiple tissues
Year(s) Of Engagement Activity 2011
 
Description International Thyroid and Parathyroid Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Highlighting skeletal consequences of thyroid disease to more than 200 physicians and surgeons from across Europe

Invitation to speak to clinicians and patients groups at Royal Society of Medicine
Year(s) Of Engagement Activity 2011
 
Description Kings College School Wimbledon 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Meeting for prospective medical and veterinary students from Kings College Wimbledon and their parents to advice regarding university applications and future career possibilities in clinical medicine and academia

Opportunity to meet candidates prior to university interview for additional advice
Year(s) Of Engagement Activity 2015
URL https://www.kcs.org.uk/
 
Description Royal Society of Medicine 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Combined audience of doctors and patient groups highlighting the impotance of inherited genetic disease in Endocrinology.

Closer interaction with the AMEND patient group.
Year(s) Of Engagement Activity 2006,2011,2013
 
Description School Visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Meeting of >50 school children interested in a career in Medicine and Science meeting with physicians and scientists which resulted in discussions about opportunities for studying and pursuing a scientific research career in basic and clinical areas.
Year(s) Of Engagement Activity 2015,2016
URL https://www.kcs.org.uk/content/science-medics-networking
 
Description Short Film for Endo-TV 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Short films highlighting the research of 12 endocrinology laboratories from around the world have been commissioned by American Endocrine Society for their centennial meeting in Boston. The Molecular Endocrinology Laboratory was selected as one of the laboratories to highlight.
Year(s) Of Engagement Activity 2016
URL https://www.endocrine.org/meetings/endo-annual-meeting/endo-2016/endo-tv
 
Description Society for Endocrinology Clinical Update 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Increase awareness of the skeletal consequences of endocrine diseases in the next generation of consultant physicians.

Workshop for doctors in sub-speciality training. Update on Endocrinology and bone disease. The 120 attendees were divided into four groups of 30 and all groups were highly interactive and gave excellent feedback on these sessions.
Year(s) Of Engagement Activity 2012
URL http://www.endocrinology.org/meetings/2012/cu2012/
 
Description Society for Endocrinology Clinical Update 2011 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Workshop for doctors in sub-speciality training. Update on Endocrinology and bone disease. The 120 attendees were divided into four groups of 30 and all groups were highly interactive and gave excellent feedback on these sessions.


Increase awareness of the skeletal consequences of endocrine disease in the next generation of consultant physicians.
Year(s) Of Engagement Activity 2011
URL http://www.endocrinology.org/meetings/2011/cu2011/
 
Description St Bartholomew's Hospital Endocrine Society, London. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Health professionals
Results and Impact St Bartholomew's Hospital Endocrine Society, London.
Title; "Origins of Bone and Cartilage Disease"
Lecture resulting in detailed discussion and advice


Increased awareness of OBCD programme
Year(s) Of Engagement Activity 2009,2013
 
Description The Academy of Medical Sciences. Academic Career Development Meeting, UEA Norwich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact 50 academic trainees attended from the East Anglian region. Detailed discussion about persuing a career in academic medicine

Contacts for future Fellowship applications.
Year(s) Of Engagement Activity 2012
 
Description Treat osteoarthritis summer school, Harris manchester College Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Highlight the role of thyroid hormone and the deiodinase enzymes in the pathogenesis of osteoarthritis

Foster new collaboration
Year(s) Of Engagement Activity 2011
 
Description Treat-Osteoarthritis Summer School, Harris Manchester College Oxford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Translational Research in Europe Applied Technologies for OsteoArthritis URL http://www.treatoa.eu/news.html
Supported by EU FP7
Title: The role of the type 2 iodothyronine deiodinase enzyme in the skeleton

Raise profile of Molecular Endocrinology Group in Osteoarthritis research
Year(s) Of Engagement Activity 2011