Wessex severe asthma cohort

Lead Research Organisation: University of Southampton
Department Name: Inflammation Infection and Repair

Abstract

Asthma is a common and disabling problem for many, particularly those with severe persistent disease that prevents them living a normal life. Standard asthma therapies are insufficient to control symptoms in these individuals and they live in fear of exacerbations that require emergency care and hospitalisation. There is thus an urgent need for the identification of novel therapeutic approaches that improve disease control and prevent disease exacerbation. To enable the more rapid conduct of trials with potential new treatments it is important to have well characterised patients, as it is recognised that severe asthma may arise from a range of causes and not all individuals are likely to benefit in the same way with specific interventions. With this in mind, this proposal will gather patients within the Wessex region with severe asthma, to form a Wessex severe asthma cohort, that can undergo detailed characterisation and be available to potentially take parts in trials of new therapies. This characterisation will involve documenting the impact of the disease on daily symptoms and quality of life, focusing on the presence and severity of nasal and sinus symptoms. Measures will be made of how well the lungs are working through a series of breathing tests. Biological samples, such as sputum, collected by inducing coughing, nasal washings, blood and urine will be collected and used to assess the nature, extent and severity of asthmatic inflammation within the airways and body. It is intended that the cohort would act as a focus for the evaluation of novel treatments that are being developed in the hope that they would lead to improvement in asthma in those with more severe disease. The characterisation would help determine which patients might best be selected for different interventions, dependent upon how these work, to give the best chance of identifying better treatments that can be developed to help improve the quality of life in those with severe asthma.

Technical Summary

This cohort of patients with persistent and severe asthma specifically responds to a significant unmet clinical need and is not duplicated within National Service Framework strategies or any Topic Specific Clinical Research Networks, as none exist for asthma. This will provide well characterised subjects that facilitate the proof of principle investigation of novel therapies with a sound rationale in this group of patients. The collection and characterisation of these patients reflects a strong partnership between NHS and academic respiratory physicians in Wessex and the close geographic localisation makes possible the potential conduct of sophisticated, mechanistic, translational, pharmacological studies that would not be possible in a widely disseminated cohort and for which Southampton has a proven track record.
Three hundred patients with asthma who, despite regular maintenance therapy at level 4 or level 5 of the British Thoracic Society asthma management guidelines, remain symptomatic and have unstable disease, in that they have a history of severe exacerbation necessitating a course of oral steroids or an increased in maintenance oral steroid dose, will be recruited. Characterisation, in addition to a detailed history which will include details of smoking habit and medication use, will consist of 1) patient centered questionnaires and diary card recording of upper and lower airway symptoms, to evaluate the impact of the disease on the individual, 2) physiological measures of lung function at home and in the laboratory before and after bronchodilator therapy, to assess lung function in relationship to the norm (predicted values), the natural diurnal variation and the short term pharmacological reversibility of any impairment, 3) biological sample collection to evaluate airway inflammation within the upper and lower airways and to store samples from induced sputum, nasal lavage, peripheral blood (serum and plasma) and urine for subsequent biomarker evaluation, for which separate funding would need to be applied for. Additional assessments include documentation of atopic status, measurement of BMI and measurement of urinary cotinine to verify tobacco smoking history.
A range of potential mechanistic proof of principle studies on novel therapies that could be undertaken on this cohort of patients with severe asthma are detailed, along with possible industrial collaborators. These focus on modifying the effect or exposure to trigger factors (viruses and bacteria), the underlying abnormal airway inflammation (eosinophilic and neutrophilic) or specific disease processes through molecular targeting.

Organisations

Publications

10 25 50
 
Description NHS Severe Asthma Commissioning
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description local asthma guidelines
Geographic Reach Local/Municipal/Regional - UK Only 
Policy Influence Type Membership of a guidance committee
 
Description 12/33 HTA CET Open Call
Amount £1,247,983 (GBP)
Funding ID PROJECT: 12/33/28 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 03/2014 
End 02/2018
 
Description IMI ENSO-3 award
Amount € 894,416 (EUR)
Funding ID Grant Agreement No 115010 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 05/2014 
End 10/2015
 
Description Innovate Medicines Innitiative/European Union/ European Federation of Pharmaceutical Industries
Amount £479,407 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 10/2010 
End 10/2015
 
Description Stratified Medicine
Amount £5,951,787 (GBP)
Funding ID MR/M016579/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2015 
End 04/2019
 
Description Stratified Medicine Pilot projects
Amount £25 (GBP)
Organisation National Institute for Health Research 
Department MRC-NIHR National Phenome Centre
Sector Academic/University
Country United Kingdom
Start 04/2016 
End 10/2016
 
Description AirProm 
Organisation University of Leicester
Department Institute for Lung Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Partner in application to EU FP7 for Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling (AirPROM). Contributing CT thorax scans from well characterised severe asthma patients
Impact None to date just started
Start Year 2010
 
Description Asthma UK Genetics of Severe Asthma (AUGOSA) 
Organisation University of Nottingham
Department School of Biomedical Sciences Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributing DNA from Wessex Severe Asthma Cohort for genome wide screen to define genetics of severe asthma
Impact (1)Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WO; GABRIEL Consortium. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010 Sep 23;363(13):1211-21.
Start Year 2009
 
Description GWAS and severe asthma 
Organisation National Institutes of Health (NIH)
Department Severe Asthma Research Programme
Country United States 
Sector Public 
PI Contribution The Wessex Severe Asthma Cohort (WSAC)characterisation included the collection of a sample for DNA analysis. There was no funding for this. Partners have been sought to enable this to happen.
Collaborator Contribution Collaboration has been set up with the US Severe Asthma Research Programme (SARP) and their centre for genetic analysis (Wake Forest University with Professors Eugen Bleecker and Debbie Meyers) to undertake a GWAS analysis similar to that conducted on the SARP population. This would serve as validatory data for SARP and novel data for WSAC. Novartis have funded the GWAS analysis through purchase of all the kits and reagents necessary for this to be undertaken. Payment has thus been in kind. Analysis will be in 2014 and interpretation in 2015.
Impact not yet
Start Year 2013
 
Description GWAS and severe asthma 
Organisation Novartis
Country Global 
Sector Private 
PI Contribution The Wessex Severe Asthma Cohort (WSAC)characterisation included the collection of a sample for DNA analysis. There was no funding for this. Partners have been sought to enable this to happen.
Collaborator Contribution Collaboration has been set up with the US Severe Asthma Research Programme (SARP) and their centre for genetic analysis (Wake Forest University with Professors Eugen Bleecker and Debbie Meyers) to undertake a GWAS analysis similar to that conducted on the SARP population. This would serve as validatory data for SARP and novel data for WSAC. Novartis have funded the GWAS analysis through purchase of all the kits and reagents necessary for this to be undertaken. Payment has thus been in kind. Analysis will be in 2014 and interpretation in 2015.
Impact not yet
Start Year 2013
 
Description Longitudinal follow up study of Wessex Severe Asthma Cohort 
Organisation Boehringer Ingelheim
Country Germany 
Sector Private 
PI Contribution PI led study (Professor Peter Howarth) in collaboration with Boehringer Ingelheim to provide follow up data on those participants of the Wessex Severe Asthma Cohort who had sputum and inflammatory mediator measures as part of their initial assessment, to understand phenotype stability and evaluate the relationship between change in inflammation and change in disease control in severe asthma.
Collaborator Contribution Boehringer Ingelheim will fund the clinical study and sample collection. Further funding will help support the sample analysis, the details of which have yet to be determined and will be undertaken in partnership.
Impact None as yet as just started
Start Year 2017
 
Description Respiratory Therapeutic Capability Cluster 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Actively involved in the establishment and application process to secure TCC status for Respiratory Medicine. The npresence of airways disease cohorts was a requirement for consideration for participation in this Capability Cluster so the Wessex Severe Asthma cohort was an important factor in Southampton's inclusion.
Impact Only recently formed so no output as yet. Respiratory with focus on asthma and COPD. Links with ABPI and large Pharma.
Start Year 2010
 
Description Respiratory Therapeutic Capability Cluster 
Organisation National Institute for Health Research
Department NIHR Biomedical Research Unit, Nottingham University Hospitals NHS Trust
Country United Kingdom 
Sector Learned Society 
PI Contribution Actively involved in the establishment and application process to secure TCC status for Respiratory Medicine. The npresence of airways disease cohorts was a requirement for consideration for participation in this Capability Cluster so the Wessex Severe Asthma cohort was an important factor in Southampton's inclusion.
Impact Only recently formed so no output as yet. Respiratory with focus on asthma and COPD. Links with ABPI and large Pharma.
Start Year 2010
 
Description Respiratory Therapeutic Capability Cluster 
Organisation Queen's University Belfast
Department Centre for Infection and Immunity
Country United Kingdom 
Sector Academic/University 
PI Contribution Actively involved in the establishment and application process to secure TCC status for Respiratory Medicine. The npresence of airways disease cohorts was a requirement for consideration for participation in this Capability Cluster so the Wessex Severe Asthma cohort was an important factor in Southampton's inclusion.
Impact Only recently formed so no output as yet. Respiratory with focus on asthma and COPD. Links with ABPI and large Pharma.
Start Year 2010
 
Description Respiratory Therapeutic Capability Cluster 
Organisation Royal Brompton & Harefield NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Actively involved in the establishment and application process to secure TCC status for Respiratory Medicine. The npresence of airways disease cohorts was a requirement for consideration for participation in this Capability Cluster so the Wessex Severe Asthma cohort was an important factor in Southampton's inclusion.
Impact Only recently formed so no output as yet. Respiratory with focus on asthma and COPD. Links with ABPI and large Pharma.
Start Year 2010
 
Description Respiratory Therapeutic Capability Cluster 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Actively involved in the establishment and application process to secure TCC status for Respiratory Medicine. The npresence of airways disease cohorts was a requirement for consideration for participation in this Capability Cluster so the Wessex Severe Asthma cohort was an important factor in Southampton's inclusion.
Impact Only recently formed so no output as yet. Respiratory with focus on asthma and COPD. Links with ABPI and large Pharma.
Start Year 2010
 
Description Respiratory Therapeutic Capability Cluster 
Organisation University of Leicester
Department Institute for Lung Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Actively involved in the establishment and application process to secure TCC status for Respiratory Medicine. The npresence of airways disease cohorts was a requirement for consideration for participation in this Capability Cluster so the Wessex Severe Asthma cohort was an important factor in Southampton's inclusion.
Impact Only recently formed so no output as yet. Respiratory with focus on asthma and COPD. Links with ABPI and large Pharma.
Start Year 2010
 
Description Respiratory Therapeutic Capability Cluster 
Organisation University of Manchester
Department School of Medicine Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Actively involved in the establishment and application process to secure TCC status for Respiratory Medicine. The npresence of airways disease cohorts was a requirement for consideration for participation in this Capability Cluster so the Wessex Severe Asthma cohort was an important factor in Southampton's inclusion.
Impact Only recently formed so no output as yet. Respiratory with focus on asthma and COPD. Links with ABPI and large Pharma.
Start Year 2010
 
Description Respiratory Therapeutic Capability Cluster 
Organisation University of Oxford
Department Oxford Centre for Respiratory Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Actively involved in the establishment and application process to secure TCC status for Respiratory Medicine. The npresence of airways disease cohorts was a requirement for consideration for participation in this Capability Cluster so the Wessex Severe Asthma cohort was an important factor in Southampton's inclusion.
Impact Only recently formed so no output as yet. Respiratory with focus on asthma and COPD. Links with ABPI and large Pharma.
Start Year 2010
 
Description U-BIOPRED 
Organisation Academic Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation Aix-Marseille University
Country France 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation Catholic University of the Sacred Heart
Country Italy 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation Fraunhofer Society
Country Germany 
Sector Private 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation Haukeland University Hospital
Country Norway 
Sector Hospitals 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation Hvidovre Hospital
Country Denmark 
Sector Hospitals 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation Imperial College London
Department National Heart & Lung Institute (NHLI)
Country United Kingdom 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation Jagiellonian University
Department Jagiellonian University Medical College
Country Poland 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation National Center for Scientific Research (Centre National de la Recherche Scientifique CNRS)
Country France 
Sector Public 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation Semmelweiss University
Country Hungary 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation Umea University
Country Sweden 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation University of Bern
Country Switzerland 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation University of Catania
Country Italy 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation University of Ghent
Country Belgium 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation University of Manchester
Department School of Medicine Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation University of Nottingham
Department School of Molecular Medical Sciences Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description U-BIOPRED 
Organisation University of Rome Tor Vergata
Country Italy 
Sector Academic/University 
PI Contribution The existance of the "Wessex severe asthma cohort" was an key component in Southampton's involvement and credibilty within this European Union and EFPIA funded IMI grant. Southampton is one of the three leading centres co-ordinating this pan-European consortium that involves 20 academic institutes, patient organisations, SMEs and industrial partners.
Collaborator Contribution Co-applicant on the IMI severe asthma U-BIOPRED application Co-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationCo-applicant on the IMI severe asthma U-BIOPRED applicationLead applicant on the IMI severe asthma grant application
Impact IMI severe asthma funding from EU/EFPIA for the consortium of €23 million Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6
Start Year 2009
 
Description serum periostin as a T2 biomarker in severe asthma 
Organisation Shino-Test Corporation
Country Japan 
Sector Private 
PI Contribution Wessex Severe asthma cohort serum samples
Collaborator Contribution measurement of serum periostin
Impact European Respiratory Society poster presentation Munich 2014 Serum periostin in asthma: A potential biomarker for stratification in severe treatment-resistant asthma H. Rupani, L. Lau, J. Ono, S. Ohta, C. Barber, S. Elliot, T. Brown, R. Kurukulaaratchy, A. Chauhan, K. Izuhara, P. Howarth (Southampton, Portsmouth, United Kingdom; Kanagawa, Saga, Japan)
Start Year 2013
 
Description somalogics anlaysis of induced sputum supernatants 
Organisation Johnson & Johnson
Country United States 
Sector Private 
PI Contribution supply of induced sputum supernatants and matching serum samples from Wessex Severe Asthma Cohort
Collaborator Contribution funding of SOMAscan™ assay of the samples by SomaLogic inc USA
Impact awaited
Start Year 2014
 
Title University of Southampton for MicroRNA Treatment for Asthma (11413 / BB Ref. JDM68318P.USP) 
Description Multiple targeting of microRNAs as a therapy for asthma Scientific Summary: Multiple targeting of microRNAs as a therapy for asthma and Inflammatory Bowel Disease. The idea is based on the results that we have obtained in our laboratory, where we have observed a dysregulation in the expression of several microRNAs, both in Asthma and Inflammatory Bowel Disease (IBD). We did not stop at this descriptive fact, but studied the implications of this dysregulation, focusing on different microRNAs in different cells types and processes. This approach has facilitated the discovery of synergies or collaborations between multiple microRNAs. We have found that multiple microRNAs may be used simultaneously as therapeutic targets, eliciting a more controlled response that individual microRNAs. Our initial experiments have shown that microRNAs that have a specific target mRNA (of therapeutic interest) in common tend to increase their affinity for this target when they are simultaneously manipulated in the cell. Having an increased preference for the common therapeutic target, these microRNAs seem to show less avidity for other targets of no therapeutic interest, reducing the potential off target effects of a potential microRNA therapy. Alveolar macrophages from asthmatics were found to significantly over express a range of miRs, including miR27, miR150, miR152, miR155 and miR375. All of these have seeding sites within the 3'UTRs of genes that lie within host defence pathways which may have a role in asthmatic exacerbation due to rhinoviral infection. MiR-150, miR-152 and miR-375, which were significantly increased in severe asthma (SA), putatively regulate TLR7 expression. Consistent with this we found TLR-7 mRNA and protein (Western blotting) to be significantly reduced in AM from volunteers with SA compared to HC (p<0.003). This was identified as functionally relevant, as AM from SA exhibited deficient interferon-beta (IFN-ß? responses to stimulation with both Imiquimod (TLR7 agonist) and HRV16 in comparison to those from HC (each p<0.05). Importantly we were able to reverse this defect using an anti-microRNA oligonucleotide mix that blocked miR-150, miR-152 and miR-375, indicative of the relevance of these miRs. This innate recognition defect will be compounded, as MiR-27, miR-152 and miR155 are predicted to target Ripk1 (which inhibits TNF-a secretion). Consistent with this we found that transfection with a mix of oligonucleotide mimics for these 3 miRs enhanced the gene expression of TNF-a in alveolar macrophages after their exposure to HRV16. Additional results also suggest the relevance of miRs to altered AM bacterial recognition in asthma. In epithelial cells from asthmatics we have found that several microRNAs are significantly downregulated (miR-18, miR19, miR-27a, miR-128 and miR-155). All of these microRNAs target the TGF-b pathway in epithelium (targeting SMAD2 and the receptor for TGF-b), an important pro-remodelling factor thought to be key in asthma pathogenesis. MicroRNA reduction in asthmatic epithelial cells increases their sensitivity to asthma, favouring expression of pro-fibrotic genes and facilitating rhinoviral replication. In samples from patients suffering of IBD we found that miR-31 and miR-155 were upregulated and that both microRNAs target IL13RA1, the mRNA for the receptor of IL13, a key cytokine in IBD. By using both pre-miR-31 and pre-miR-155 oligonucleotides simultaneously on clinical biopsies from inflamed colon, we were able to show that genes dependent on IL13 stimulation were reduced (CCL18, SOCS1). Importantly, using the pre-miR-155 oligonucleotide alone increased TNF-?, an undesired and dangerous off target effect. However, when miR-155 was combined with pre-miR-31 this effect disappeared and only the common effects (reduction of IL13 dependent genes) were apparent and further increased. We claim that, by using multiple microRNA therapy, specific to pathology related signalling pathways and to the affected cells (epithelium, macrophages, etc) we enhance the effect of a potential microRNA therapy an can reduce its off target effect. 
IP Reference United Kingdom Patent Application No: 1316651.7, Patent Application No. 14/490 280 in USA 
Protection Patent application published
Year Protection Granted 2014
Licensed No
Impact Work on going
 
Description Advisory board severe asthma 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Advisory board concerning drug development in severe asthma
Year(s) Of Engagement Activity 2015
 
Description Advisory board severe asthma 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Pharmaceutical company advisory board re drug development in severe asthma

help develop direction of drug development
Year(s) Of Engagement Activity 2012,2013,2014
 
Description Conference on Clincal and Pharmacological aspects of asthma management 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact lecture on "Pharmacological modulation of airway remodelling in asthma" highlighting the preventative strategies in asthma therapy to prevent long term decline in lung function and how this influences everyday practice in asthma management
Year(s) Of Engagement Activity 2016
 
Description EU grant review re severe asthma 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact IMI JU Interim Review Meeting for U-BIOPRED (project no 115010). Presentation as WP leader.

successful approval of grant progress
Year(s) Of Engagement Activity 2012
 
Description European Academy of Allergy, Asthma and Clinical Immunology Conference presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Presentation on "The Airway Microbiome and Asthma" at pleneray symposium on Wednesday 26 June
Presentation entitled "Pathology of the small airways in asthma" at the joint World Allergy Organisation and EAAACI symposium on Monday, 24 June 2013

Involvement in World Allergy Organisation publication on Small Airways and Asthma
Year(s) Of Engagement Activity 2013
 
Description Newspaper article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Article in local Southampton Echo newspaper about severe asthma needs and also a second outlining research activity in Southampton

general awareness of asthma
Year(s) Of Engagement Activity 2012
 
Description Wessex Asthma Network meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact presentation on "How can phenotyping guide our management? " to primary care physicians, secondary care specialists, physiotherapists, specialist nurses, specialist commissioners, psychologists and patient representatives. Part of network meeting to promote asthma care and delivery of specialist services within the Wessex Region.
Year(s) Of Engagement Activity 2015
 
Description Workshop severe asthma 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Workshop considering how to diagnose severe asthma and approaches to severe asthma management, complemented by clinical cases and group discussions
Year(s) Of Engagement Activity 2015
 
Description World Allergy Organisation conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Several presentations at International conference relating to aspects of severe asthma. Titles "Asthma therapy based on phenotypes and response to ICS of eosinophilic and non-eosinophilic type", "Impact of Environmental Factors on Modulating Epithelial Cell Function in Asthma" and "IL-17 and Th17 Cells in Asthma and Inflammation". These all included data derived from the Wessex Severe Asthma Cohort. Interactions with Korean workers interested in severe asthma.
Year(s) Of Engagement Activity 2015
 
Description World Asthma Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact lecture on "Non-Inflammatory mechanisms of airway remodelling" highlighting the importance of addressing bronchoconstriction as well as airway inflammation in management of asthma
Year(s) Of Engagement Activity 2016
 
Description preceptorship severe asthma meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact organisation and conduct of a one day workshop on severe asthma for respiratory specialists
Year(s) Of Engagement Activity 2015
 
Description talk for Netherlands Lung Foundation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/parliamentarians
Results and Impact talk and workshop for Netherlands Lung Foundation on "Current treatment of asthma and current medical needs" to help in their decision process re forward planning for funding strategy

appreciation of the help given
Year(s) Of Engagement Activity 2014