North West HTMR
Lead Research Organisation:
University of Liverpool
Department Name: Medical Statistics and Health Evaluation
Abstract
The best method for finding out whether one treatment is better than another is to perform a research study known as a randomised controlled trial, in which treatments are allocated to patients at random, rather like throwing a dice to decide. Studies like this are not without their difficulties. For example, when drugs are first trialled, the research should proceed in stages with evaluation at each stage. As treatments move into the later phases of study, researchers must choose which outcomes are most important to measure, a decision ideally arrived at through consideration of both the clinical and patient perspective. This proposal is to create a world-class centre where issues such as these facing the clinical trials community can be investigated, the overall aim being to improve patient care by improving the evidence on which decisions about healthcare are based.
Technical Summary
The gold standard study design for determining efficacy of a treatment is the randomised controlled trial (RCT) but trials are not without their difficulties (Prescott et al, 1999). This proposal is to create a world-class centre where methodological issues facing the clinical trials community can be investigated, the overall aim being to improve patient care by improving the validity and relevance of the healthcare evidence base. This will include provision of a training programme that will deliver individuals with the capacity to be leading clinical trialists and methodologists.
The Hub will focus on selected methodological research themes, initially developing and translating the methods for application across four clinical areas. The methodological areas include the promotion, modification and implementation of recently devised methods for improving the efficiency of a wide variety of early phase trials, the enhancement of the link between the findings of systematic reviews and the design of later phase trials particularly in relation to outcome selection (Clarke 2007, Sinha 2008), the development and application of methods of adjustment for non-compliance in both clinical and cost effectiveness analyses, and ensuring that the design and conduct of trials over their entire lifecourse is informed by evidence on the perspectives of patients. This will enable the design, interpretation, and dissemination of the results of RCTs that are of greater relevance to stakeholders.
The Hub will focus on selected methodological research themes, initially developing and translating the methods for application across four clinical areas. The methodological areas include the promotion, modification and implementation of recently devised methods for improving the efficiency of a wide variety of early phase trials, the enhancement of the link between the findings of systematic reviews and the design of later phase trials particularly in relation to outcome selection (Clarke 2007, Sinha 2008), the development and application of methods of adjustment for non-compliance in both clinical and cost effectiveness analyses, and ensuring that the design and conduct of trials over their entire lifecourse is informed by evidence on the perspectives of patients. This will enable the design, interpretation, and dissemination of the results of RCTs that are of greater relevance to stakeholders.
Publications
Catt H
(2019)
Value Assessment and Quantitative Benefit-Risk Modelling of Biosimilar Infliximab for Crohn's Disease.
in PharmacoEconomics
Catt H
(2019)
Systematic review: outcomes and adverse events from randomised trials in Crohn's disease.
in Alimentary pharmacology & therapeutics
Richards DA
(2019)
Integrating quantitative and qualitative data and findings when undertaking randomised controlled trials.
in BMJ open
Hill-McManus D
(2019)
Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout.
in Clinical pharmacology and therapeutics
Razanskaite V
(2020)
P178 Variation in assessment of outcomes for inflammatory bowel disease in routine clinical practice: a mixed-methods study
in Journal of Crohn's and Colitis
| Description | An assessment of the impact of outcome reporting bias in randomised controlled trials within systematic trials |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Guideline Title | NICE Guideline |
| Description | Citation in clinical guidelines |
| Geographic Reach | National |
| Policy Influence Type | Citation in clinical guidelines |
| Description | HTA outline proposal form now includes reference to COMET |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Impact of outcome reporting bias |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Implications for driving |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Providing evidence to coincide with currently recognised UK guidance on driving for patients with epilepsy. From this a change in policy has resulted in the UK and it is planned to use this analysis to harmonise EU and UK driving regulations. This work is not directly related to trials methodology but this demonstrates added value since work benefited from methods applied to analysis of trials data. |
| Description | Methods referred to in Cochrane handbook |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | SPIRIT 2013 guidance for protocols of clinical trials now includes reference to COMET |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Butterfield Awards for UK-Japan Collaboration in Medicine and Health |
| Amount | £3,000 (GBP) |
| Organisation | The Great Britain Sasakawa Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2012 |
| End | 08/2013 |
| Description | Career Development Fellowship |
| Amount | £301,658 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Cochrane Programme Grant |
| Amount | £480,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2011 |
| End | 01/2014 |
| Description | Framework Programme 7 |
| Amount | € 497,368 (EUR) |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 09/2012 |
| End | 09/2014 |
| Description | MRC Trials Methodology Fellowship |
| Amount | £166,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2014 |
| End | 08/2017 |
| Description | MRC/ARUK Musculoskeletal Ageing Centre (Liverpool/Sheffield/Newcastle) |
| Amount | £1,875,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MRC/ARUK Musculoskeletal Ageing Centre (Liverpool/Sheffield/Newcastle) |
| Amount | £625,000 (GBP) |
| Organisation | Versus Arthritis |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Methodology Panel Award |
| Amount | £685,814 (GBP) |
| Funding ID | G0902155 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2011 |
| End | 05/2013 |
| Description | Methodology Research Panel |
| Amount | £549,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2012 |
| End | 03/2015 |
| Description | Methodology Research Panel |
| Amount | £173,273 (GBP) |
| Funding ID | MR/J004847/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2012 |
| End | 10/2014 |
| Description | NIHR |
| Amount | £30,000 (GBP) |
| Funding ID | RMOFS 2012/09 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 09/2014 |
| Description | NIHR HTA |
| Amount | £1,536,010 (GBP) |
| Funding ID | 12/127 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2014 |
| End | 08/2018 |
| Description | Network of Hubs for Trials Methodology Research R1 |
| Amount | £50,000 (GBP) |
| Funding ID | R1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2010 |
| End | 07/2011 |
| Description | Network of Hubs for Trials Methodology Research R13 |
| Amount | £2,300 (GBP) |
| Funding ID | R13 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2011 |
| End | 12/2011 |
| Description | Network of Hubs for Trials Methodology Research R14 |
| Amount | £15,712 (GBP) |
| Funding ID | R14 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2011 |
| End | 12/2012 |
| Description | Network of Hubs for Trials Methodology Research R18 |
| Amount | £46,220 (GBP) |
| Funding ID | R18 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2012 |
| End | 04/2013 |
| Description | Network of Hubs for Trials Methodology Research R19 |
| Amount | £36,314 (GBP) |
| Funding ID | R19 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2012 |
| End | 02/2013 |
| Description | Network of Hubs for Trials Methodology Research R24 |
| Amount | £16,052 (GBP) |
| Funding ID | R24 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2012 |
| End | 08/2013 |
| Description | Network of Hubs for Trials Methodology Research R30 |
| Amount | £49,082 (GBP) |
| Funding ID | R30 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2012 |
| End | 09/2013 |
| Description | Network of Hubs for Trials Methodology Research R31 |
| Amount | £12,721 (GBP) |
| Funding ID | R31 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2012 |
| End | 05/2013 |
| Description | Network of Hubs for Trials Methodology Research R46 |
| Amount | £7,000 (GBP) |
| Funding ID | R46 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 11/2014 |
| Description | Network of Hubs for Trials Methodology Research R5 |
| Amount | £32,523 (GBP) |
| Funding ID | R5 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2011 |
| End | 02/2012 |
| Description | Network of Hubs for Trials Methodology Research R7 |
| Amount | £12,941 (GBP) |
| Funding ID | R7 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2010 |
| End | 06/2011 |
| Description | Patient-centred trials: developing measures to improve the experience of people taking part in clinical trials |
| Amount | £149,827 (GBP) |
| Funding ID | PB-PG-0416-20033 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2018 |
| End | 07/2019 |
| Description | Post-doctoral Research Fellowship |
| Amount | £169,000 (GBP) |
| Funding ID | 095874/2/11/2 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2012 |
| End | 03/2015 |
| Description | Project Grant |
| Amount | £240,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2011 |
| End | 05/2013 |
| Description | Project grant |
| Amount | £2,000,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Research Fellowship Programme |
| Amount | CHF 280,000 (CHF) |
| Organisation | F. Hoffmann-La Roche AG |
| Department | Roche Diagnostics |
| Sector | Private |
| Country | Global |
| Start | |
| Description | Research Methods Fellowship |
| Amount | £91,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 09/2015 |
| Description | Research Methods Fellowship |
| Amount | £91,000 (GBP) |
| Funding ID | MET-2012-12-27 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 03/2015 |
| Description | Research Methods Fellowship |
| Amount | £91,000 (GBP) |
| Funding ID | MET-2012-18 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2012 |
| End | 09/2014 |
| Description | School for Primary Care Research Capacity |
| Amount | £42,251 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2014 |
| End | 06/2015 |
| Description | The Research for Patient Benefit Programme |
| Amount | £250,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | Research for Patient Benefit |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2010 |
| End | 01/2012 |
| Title | Joiner |
| Description | Novel methods for joint modelling combined repeated measurements and event-time data, or informative drop-out were developed and published. These methods were exploited fully in substantive applications over a range of medical settings including epilepsy treatment, cardio-thoracic surgery and renal medicine. Software for the new methods was developed as an add-on package ("JoineR") within the R environment so as to make the software freely available to researchers. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | Joint modelling approach provided the clinical research community with an awareness of the potential problems commonly occur in clinical and observational studies and the inefficiency of use of simple statistical methods which are often failing to take account of informative dropout during the intended follow-up period. Thereby we have improved current practice in the analysis of the complex longitudinal data structures that commonly arise in clinical and public health research. |
| Title | ORBIT |
| Description | Outcome reporting bias is an under-recognised problem which can affect the inference in a systematic review. Reviewers should address explicitly the issue of missing outcome data in order for reviews to be considered a reliable source of evidence about healthcare practice. We have proposed an outcome matrix be used for this purpose alongside the development of a new classification system for the assessment of selective outcome reporting. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | The main findings were that a third of Cochrane reviews contained at least one trial with high outcome reporting bias (ORB) suspicion for the review primary outcome. Considering meta-analyses with a statistically significant result only, just under a fifth were not robust to ORB and over a quarter would have overestimated the treatment effect by 20% or more. We found ORB to be an under-recognised problem which affects the inference in a substantial proportion of Cochrane reviews. |
| Description | COMET Initiative |
| Organisation | Medical Research Council (MRC) |
| Department | MRC All-Ireland Hub for Trials Methodology Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Led in the set up of the COMET Initiative with collaboration from colleagues in the All-Ireland HTMR, Conduct HTMR and University of Oxford. A joint grant application was made by the four collaborating centres to the MRC Network of Hubs for Trials Methodology Research and £50000 was awarded. |
| Collaborator Contribution | Member of the COMET Initiative Management GroupMember of the COMET Initiative Management GroupMember of the COMET Initiative Management Group |
| Impact | COMET Initiative Launch meeting, Liverpool 2010 2nd meeting of the COMET Initiative, Bristol 2011 Design and launch of the COMET Initiative website 2011 COMET Initiative blog series established with the BMJ Advice on core outcomes informed NICE 2011 epilepsy guidelines COMET featured on the homepage of the NIHR website Addition to NIHR HTA application form, explicitly referencing importance of core outcomes sets, the COMET Initiative and website |
| Start Year | 2010 |
| Description | COMET Initiative |
| Organisation | Medical Research Council (MRC) |
| Department | MRC ConDuCT Trials Methodology Hub |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Led in the set up of the COMET Initiative with collaboration from colleagues in the All-Ireland HTMR, Conduct HTMR and University of Oxford. A joint grant application was made by the four collaborating centres to the MRC Network of Hubs for Trials Methodology Research and £50000 was awarded. |
| Collaborator Contribution | Member of the COMET Initiative Management GroupMember of the COMET Initiative Management GroupMember of the COMET Initiative Management Group |
| Impact | COMET Initiative Launch meeting, Liverpool 2010 2nd meeting of the COMET Initiative, Bristol 2011 Design and launch of the COMET Initiative website 2011 COMET Initiative blog series established with the BMJ Advice on core outcomes informed NICE 2011 epilepsy guidelines COMET featured on the homepage of the NIHR website Addition to NIHR HTA application form, explicitly referencing importance of core outcomes sets, the COMET Initiative and website |
| Start Year | 2010 |
| Description | COMET Initiative |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Led in the set up of the COMET Initiative with collaboration from colleagues in the All-Ireland HTMR, Conduct HTMR and University of Oxford. A joint grant application was made by the four collaborating centres to the MRC Network of Hubs for Trials Methodology Research and £50000 was awarded. |
| Collaborator Contribution | Member of the COMET Initiative Management GroupMember of the COMET Initiative Management GroupMember of the COMET Initiative Management Group |
| Impact | COMET Initiative Launch meeting, Liverpool 2010 2nd meeting of the COMET Initiative, Bristol 2011 Design and launch of the COMET Initiative website 2011 COMET Initiative blog series established with the BMJ Advice on core outcomes informed NICE 2011 epilepsy guidelines COMET featured on the homepage of the NIHR website Addition to NIHR HTA application form, explicitly referencing importance of core outcomes sets, the COMET Initiative and website |
| Start Year | 2010 |
| Title | COMET Website |
| Description | The COMET website hosts a searchable database. The website is currently live. The website was developed using funding awarded by the MRC Network of Hubs for Trials Methodology Research. |
| Type | Support Tool - For Fundamental Research |
| Current Stage Of Development | Small-scale adoption |
| Year Development Stage Completed | 2011 |
| Development Status | Under active development/distribution |
| Impact | From its launch in August 2011 to date the website has had 56,893 database searches and 177,017 unique visitors from 199 countries. |
| URL | http://www.comet-initiative.org/ |
| Title | DIRUM website |
| Description | The DIRUM (Database of Instruments for Resource Use Measurement) website provides a practical, open-access database of resource-use questionnaires for use by trial health economists. The website is currently live. The website received funding from the MRC Network of Hubs for Trials Methodology Research. |
| Type | Support Tool - For Fundamental Research |
| Current Stage Of Development | Small-scale adoption |
| Year Development Stage Completed | 2011 |
| Development Status | Under active development/distribution |
| Impact | Since its launch on 6 June 2011 to 14 November 2011 the website has had 1971 visits and 440 downloads. |
| Title | Statistical software |
| Description | Shareware software to implement methods developed. |
| Type | Support Tool - For Fundamental Research |
| Current Stage Of Development | Small-scale adoption |
| Year Development Stage Completed | 2009 |
| Development Status | Under active development/distribution |
| Impact | Request for access from researchers. |
| Description | COMET talk, 2nd UK Clinical Trials Methodology Conference, Edinburgh, 2013 (LG) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Abstract accepted to present systematic review Not known yet. |
| Year(s) Of Engagement Activity | 2013 |
| Description | COMET talk, ECRIN 2013 PW |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The aims and progress of the COMET Initiative were described The talk raised awareness amongst international clinical research groups |
| Year(s) Of Engagement Activity | 2013 |
| Description | COMET talk, EQUATOR 2012 PW |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The aims and progress of the COMET Initiative were described The talk raised awareness amongst international clinical research groups |
| Year(s) Of Engagement Activity | 2012 |
| Description | COMET talk, Exploiting Existing Data for Health Research" 4th International Conference hosted by the Scottish Health Informatics Programme in association with the four UK Ehealth Informatics Research Centres, St Andrews, 2013 (PW) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Abstract accepted for oral presentation. Opened up a new area of interest. |
| Year(s) Of Engagement Activity | 2013 |
| Description | COMET talk, HSRN Symposium 2013, UK (PW) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Abstract selected for oral presentation. Not known yet. |
| Year(s) Of Engagement Activity | 2013 |
| Description | COMET talk, InFACT/ISF Outcome Measures Colloquium, Amsterdam, 2013 (PW) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk delivered and active participation in workshop. Ongoing collaboration. |
| Year(s) Of Engagement Activity | 2013 |
| Description | COMET talk, Network of Hubs for Trials Methodology Annual Meeting, Oxford, 2013 (LG) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk delivered. Question and answer session. Slides of presentation shared. |
| Year(s) Of Engagement Activity | 2013 |
| Description | COMET talk, PSI Annual conference, Glasgow, 2013 (PW) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Delivered to wider audience. Talk well received, audience participation and questions. Advice provided. |
| Year(s) Of Engagement Activity | 2013 |
| Description | COMET talk, Workshop on the methods for benefit-risk analysis in drug regulation and health technology assessment, Bangor, Jan 2013 (PW) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Delivered to specialist audience, increased awareness and interest in the COMET Initiative. Further discussions. |
| Year(s) Of Engagement Activity | 2013 |
| Description | COMET workshop, 21st Cochrane Colloquium, Canada, 2013 (PW) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Interactive workshop delivered, attended by 25 individuals. Feedback sought from systematic reviewers about suitability of workshop for this audience. |
| Year(s) Of Engagement Activity | 2013 |
| Description | COMET workshop, Kyoto, Japan, 2013 (PW, MC and LG) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | 2 day workshop delivered, attended by approximately 100 individuals from all over Japan. Introduced Japanese researchers to the COMET Initiative and the idea of core outcome sets. Recieved excellent feedback and was very well received. On-going discussion regarding possibility of future collaboration. |
| Year(s) Of Engagement Activity | 2013 |
| Description | COMET workshop, NICE 2011 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | A COMET workshop was delivered at a National Institute for Health and Clinical Excellence (NICE) National Collaborating Centres (NCC) Technical Meeting. This was attended by over 40 participants involved in the NICE guideline development process. The objectives of the workshop were to identify problems with outcomes in clinical trials and the subsequent impact for systematic reviews/reviewers and guidelines/guideline developers, and to consider core outcome sets as a solution to these problems. The workshop included formal presentation, group exercise and discussion. We were approached by the programme manager for the Patient and Public Involvement programme at NICE, who runs workshops with patients, who asked if they could use one of the examples from the group exercise in their workshops with patients, as it would be a great way of getting patients to think about outcomes. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Cochrane Conference presentations |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Consumers attended workshop. Well received. |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011 |
| Description | DIRUM workshop 2011 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | On 19th October 2011 a workshop was held in Birmingham where 40 people, mostly academic, contributed to discussions on methods for the collection of resource use data. Group and panel discussions resulted in a short listing of priority areas for defining a research agenda. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Grand Round 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Health professionals |
| Results and Impact | Presented findings from RECRUIT on parents' and practitioners' perspectives on recruitment to children's clinical trials at Alder Hey Children's Hospital, May 2011. Discussions following presentation led to funding application |
| Year(s) Of Engagement Activity | 2011 |
| Description | International Clinical Trials Day 2012 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Invited to speak about the COMET Initiative as part of the European Clinical Research Infrastructure Network's 2012 International Clinical Trials' Day Celebration in Dublin on 18th May 2012 http://www.ecrin.org/index.php?id=34 Participants at the meeting asked for details of the next meeting of the COMET Initiative. |
| Year(s) Of Engagement Activity | 2012 |
| Description | JLA teleconference 2012 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A teleconference was held following a request for advice from NICE and JLA about COMET and methods for core outcome set development. Agreement to work in partnership. |
| Year(s) Of Engagement Activity | 2012 |
| Description | JoineR Workshop 2013, Newcastle RKD |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | 13 participants. The workshop was interactive throughout where participants discuss applying the methods in their clinical data, and had hands-on experience in using the software JoineR. The workshop has received very positive feedback. All participants considered use of joint modelling in their future research and improved their understanding of the relevance of joint modelling ideas to substantive clinical research. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Joint modelling talk, Budapest 2013 RKD |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | 30-40 participants. The talk was followed by a lively discussion where participants discussed applying the methods in their clinical and biolomedical research. Requests for the software JoineR. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Joint modelling talk, London 2013 RKD |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | 50-60 participants. The talk was followed by a lively discussion where participants discussed applying the methods in their clinical and biolomedical research. Several participants approached to discuss their projects involving longitudinal data and requested the software JoineR. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Local COMET meeting 2012 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | A meeting was held in Liverpool on 17th January 2012 for those with interest in core outcome sets development projects that are being led from Liverpool. Individuals discussed their projects and shared their expertise and ideas. Some important methodological considerations were raised, including the necessity to define the scope of each core outcome set as each will be unique, the importance of the questions you ask to patients and clinicians and the differences in methods being used. |
| Year(s) Of Engagement Activity | 2012 |
| Description | NRES training day 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented findings from RECRUIT and CACE on children and young people's perspectives on recruitment to clinical trials at National Research Ethics Service Training Day, November 2011. Aimed to help ethics committee members understand what is (and is not) important to young people when they are approached about entering a clinical trial |
| Year(s) Of Engagement Activity | 2011 |
| Description | ORBIT workshop / presentations |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Members of the research team have presented the findings at several national and international research meetings. During the project, the ORBIT workshop was developed and delivered, usually by three of the team, at several Cochrane meetings (Dublin, Freiburg, Edinburgh, Halifax, Singapore). The workshop includes a small group exercise, in which participants read trial reports and use our classification system to determine the likelihood of outcome reporting bias. The examples we use are chosen to illustrate a variety of classifications and are taken from systematic reviews where we have obtained the information from the trialist themselves. The workshop also demonstrates how our classification of the risk of outcome reporting bias helps to assess the related dimension in the new 'Risk of bias' tool being used by the Cochrane Collaboration. The presentations have focussed on both the prevalence and impact of outcome reporting bias in a large unselected cohort of Cochrane systematic reviews (see BMJ publication) and interviews with trialists to understand the reasons for discrepancies between outcomes specified in the trial protocol and those reported in the study publication (submitted to BMJ). The feedback evaluations received from the most recent workshop have been extremely positive with all participants finding the workshop useful, and 60-75% finding it very useful. Recently, the Cochrane Bias Methods Group designated this a 'core' workshop which enabled one of our team to attend the Cochrane Colloquium in Singapore for free. |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009 |
| Description | PACT workshop, Manchester 2014 (PB) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | 20 participants knowledge exchange and identification of future methodological research to improve patient experience of trials Links with INVOLVE |
| Year(s) Of Engagement Activity | 2014 |
| Description | RSS meeting 2012 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Approx 50 people from a range of institutions attended a talk on a joint modelling approach to determine the predictive accuracy of a longitudinal biomarker. The talk was followed by a lively discussion where participants discussed applying the methods in their clinical data/settings Participants requested the software JoineR |
| Year(s) Of Engagement Activity | 2012 |
| Description | School visit - Wirral |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A talk about clinical trials Teacher fedback that it was well received by students. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Talk, 16th Annual J&J Pharma Statistics Conference (TJ) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wider dissemination of work Discussions about implementation of method with Janssen Pharmaceutica |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, 35th Conference of the International Society for Clinical Biostatistics (TJ) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wider dissemination of work Discussions about implementation of method with a CRO |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, 35th Conference of the International Society for Clinical Biostatistics 2014 (AC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wider dissemination of work None at present |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, 35th Conference of the International Society for Clinical Biostatistics 2014 (LH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Wider dissemination of work None |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, 35th Conference of the International Society for Clinical Biostatistics 2014 (WYY) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wider dissemination of work None at present |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, 36th Society for Clinical Trials Conference 2015 (TJ) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Raising profile of Hub; Dissemination of hub research NA |
| Year(s) Of Engagement Activity | 2015 |
| Description | Talk, 5th Annual Summit for Clinical Ops Executives 2014 (AHM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Dicussion No notable impacts |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, Barcelona Biomed 2012 LH |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Communicated research to broad audience of statisticians and received useful feedback from the audience Not measurable yet |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, Berlin 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Medical statisticians attended a talk presenting the results of methodological research. Methods have now been implemented in open-source R package upon request from audience. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Talk, Birmimgham 2013 RKD |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | 150 participants. The talk was followed by a lively discussion. Several participants approached to discuss their projects involving longitudinal biomarker data. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Talk, Cambridge 2012 LH |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Communicated research to a wider audience Subsequently approached to share presentation slides with members of audience |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, EMA 2012 LH |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Communicated research findings to PDCO and obtained their feedback on project Not measurable yet |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, Florence 2014 (TJ) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wider dissemination of work None at present |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, Germany 2014 (TJ) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wider dissemination of work None at present |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, Heidelberg 2012 DM |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | The talk contained some mathematical results concerning simultaneous confidence intervals for a multidimensional parameter, e.g., the treatment effect sizes in a multi-arm clinical study New methodology for analyzing clinical trials involving multiple comparisons |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, Heidelberg 2012 LH |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Communicated research to a wider audience Not yet measurable |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, Institute Gustave-Roussy 2014 (LH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Wider dissemination of work Developed a collaboration with Dr Marie-Cecile Le Deley which has culminated in joint supervision of a PhD student who started in October 2014 and is developing novel Bayesian designs for clinical trials in rare cancers |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, Institute of Population Health Postgraduate showcase 2014 (AHM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Discussion Not aware of any notable impacts |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, Liverpool 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk to a broad audience of basic researchers, clinicians, policy makers, industry and the public on a novel early phase trial design. Novel early phase trial design is currently being implemented in a CRUK trial. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Talk, London 2012 JW |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | The talk presented early ideas on eliciting opinion which, after refinement and improvement, has led to the methodology implemented for the MYPAN trial The meeting led to exchange of ideas and promotion of the Bayesian approach. There has been subsequent interest in using the methodology, but attribution to any particular meeting is difficult. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, MRC/NIHR Methods Fellows Meeting 2014 (RE) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Discussion with audience about MRC career's options, and stratified medicine research Collaboration with Newcastle around methodology work |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, Manchester 2012 BY |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Health professionals |
| Results and Impact | Practitioners are concerned about the burden posed to families by inviting children to participate in clinical trials but families report that they are happy to be approached about clinical trials Not known |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, Manchester 2012 KP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | This was a national talk for all MRC hub associated PhD students allowing communication between PhD students between different institutions The talk was well received and allowed communication between PhD students between different institutions. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, Manchester 2014 (PB) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Education and training Change in practice in attendants |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, Mini Symposium on alternative methods for dose-finding and dose-ranging trials 2015 (TJ) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Raising profile of Hub; Dissemination of hub research Has led to Merck adopting a model based approach to dose finding for the first time |
| Year(s) Of Engagement Activity | 2015 |
| Description | Talk, Neonatal and Midwifery Collaboration on Research Delivery meeting Birmingham 2015 (BY) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Health professionals |
| Results and Impact | Dissemination of Hub research particularly RECRUIT study |
| Year(s) Of Engagement Activity | 2015 |
| Description | Talk, Newcastle 2012 TJ |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | It has allowed wider dissemination of the work None known of |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, Norway 2012 KP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This was an international talk where the audience were International Biostatisticians from both academia and industry The talk was well received and some connections were made with industry professionals who offered advice about practical considerations |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, Novartis internal statistics seminar series 2014 (SS) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wider dissemination of work None |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, Oslo 2012 TJ |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | It has allowed wider dissemination of the work Some discussions on using our methods in different studies |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, PSI 2012 TJ |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | It has allowed wider dissemination of the work Some discussions on using our methods in different studies |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, RSS 2012 TJ |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | It has allowed wider dissemination of the work Some discussion on using our methods in a study |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, SMi Conference on Adaptive designs in Clinical Trials 2014 (LH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Wider dissemination of work to the pharmaceutical industry None |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk, Southampton 2012 DM |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | The talk contained some mathematical results concerning simultaneous confidence intervals for a multidimensional parameter, e.g., the treatment effect sizes in a multi-arm clinical study New methodology for analyzing clinical trials involving multiple comparisons |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, Southampton 2012 KP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | This was a national talk for all PhD students in Statistics, including some participants from Europe. This talk included students from outside of the medical statistics background to understand different contexts for methodology and input into the methodological aspects was offered. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, Symposium on Early Phase Dose Finding Methodology 2015 (TJ) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Raising profile of Hub; Dissemination of hub research NA |
| Year(s) Of Engagement Activity | 2015 |
| Description | Talk, Tokyo 2012 DH |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The presentation included an overview of the methods of health technology assessment of novel genetic predictors of drug response. The intention was to stimulate UK/Japan collaborative research in the area of personalised medicine |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, UK 2013 TJ |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | It has allowed wider dissemination of the work Some specific queries about implementing our methods |
| Year(s) Of Engagement Activity | 2013 |
| Description | Talk, Wales 2012 DH |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Health professionals |
| Results and Impact | The presentation concerned the cost-effectiveness of dabigatran, rivaroxaban, apixaban and warfarin for the management of patients with atrial fibrillation The research informed the development of the advice in Wales on the role of the new oral anticoagulants, and was submitted for consideration by NICE, of the cost-effectiveness of dabigatran |
| Year(s) Of Engagement Activity | 2012 |
| Description | Talk, Warwick 2012 TJ |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | It has allowed wider dissemination of the work Joint research with the Warwick group |
| Year(s) Of Engagement Activity | 2012 |
| Description | Visit to Vienna 2011 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | A visit was made to the Medical University in Vienna to work with experts in the field of adaptive designs. Many opportunities for collaborations and joint work were identified and the first joint project is nearing its finalisation. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Workshop, Bangor 2013 DH |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The aim of the workshop was to develop a research agenda on the assessment of benefits in relation to harm in the context of health technology assessment Draft paper in preparation |
| Year(s) Of Engagement Activity | 2013 |
| Description | Workshop, Canada 2012 BY |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Identification of key points of difference in models and areas for future research Lead to an idea for a paper, which has been drafted (by a workshop participant) and is expected to be submitted soon |
| Year(s) Of Engagement Activity | 2012 |
| Description | Workshop, Liverpool 2012 CTS |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | 50 delegates with 34 registered CTUs, 6 hubs and the MHRA represented attended a workshop on monitoring in Liverpool. As a result of the workshop an invitation was received to present a workshop at the Trial Managers Network conference. Since the workshop we have received a request for one of the CTUs to visit the Clinical Trials Research Centre to discuss monitoring practice further. Another CTU has requested further information about developing central statistical monitoring methods. A further CTU has requested information on the risk assessment approach used at CTRC. Another CTU has visited the CTRC to discuss monitoring approaches. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Workshop, Manchester 2012 PW |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | Regional |
| Primary Audience | Health professionals |
| Results and Impact | 38 leading trialists attended a workshop and explored greater clinical collaboration on methodological issues in trials Following the meeting suggestions were received from participants on how clinical engagement can be increased, in particular engagement with ACFs. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Workshop, Nuffield Council on Bioethics 2014 (BY) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | Discussion of wide range of ethical, methodological, PPI and practical issues related to children's research worldwide Nuffield Council report due April 2015 |
| Year(s) Of Engagement Activity | 2014 |