A multi-site study of the genetics of child anxiety and predictors of treatment response

Lead Research Organisation: King's College London
Department Name: Social Genetic and Dev Psychiatry Centre

Abstract

Background: Anxiety is a common and debilitating problem for our youth, shows continuity into adulthood and is associated with wide-ranging difficulties. Those individuals who first experience an anxiety disorder during their childhood show the poorest long-term outcomes. For example, such children are much more likely than other children to be absent for significant portions of their schooling missing out on the opportunity for both social and academic development. Whilst it is clear that both genetic and environmental influences are important in the development of anxiety, we know relatively little about the specific factors and mechanisms involved. More is known about the genetics of depression, which has been shown to be genetically similar to anxiety, thus providing several useful starting points for genetic studies of anxiety. Finally, whilst child anxiety is most commonly treated using a ?talking treatment? called cognitive-behaviour therapy (CBT), around two-fifths of patients do not improve. Younger girls seem more likely to respond well, whereas those with worse symptoms or whose parents also have difficulties with anxiety and/or depression respond less well. These two factors suggest that these children may have a heavier genetic loading for anxiety, implying a possible genetic influence on treatment response. Research Plan: Genes for which there is theoretical and experimental evidence for involvement in anxiety or depression will be considered in this study. For example, genes involved in the serotonin system, the target of common anti-depressants such as Prozac, have been shown to play a role in the development and pharmacological treatment of depression, and in several anxiety-related characteristics such as extreme shyness in children. We will consider the role of these and other selected genes in the development and treatment of child anxiety. DNA (genetic material) collected from a sample of 2500 children with clinical anxiety, most of whom are being treated with CBT will be used to examine two core questions. First, are there specific genes associated with childhood anxiety disorders? Second, can we predict treatment outcome from factors such as age, sex, severity of anxiety, parental mental health and specific genes? Identifying genes relevant to the development of anxiety disorders could enable targeted prevention work, whilst knowledge of genes relevant to treatment response could allow for individualised treatment programmes.

Technical Summary

Background. Anxiety disorders are highly debilitating illnesses. They affect 5-10% of children at any time and show considerable continuity into adulthood. They are influenced by genetic and environmental factors, but the specific genes involved remain largely unknown. The most common treatment is cognitive-behaviour therapy (CBT), which leads to an improvement in around 60% of cases, thus 40% remain anxious. Younger girls tend to do well following CBT, whereas adolescents and males respond less well. Furthermore, those with more severe symptoms and a history of parental anxiety/depression, also respond poorly indicating that treatment response may be partially under genetic influence.

Objectives. The two key goals are: first, to identify associations between specific candidate genes and childhood anxiety disorder; second, to consider predictors of treatment response including age, sex, symptom severity, parental psychopathology and specific genetic markers.

Design. We will collect DNA from around 2500 children with clinically diagnosed anxiety, the majority of whom are undergoing cognitive-behaviour therapy. Controls consist of 4,000 children from a longitudinal study based at the SGDP Centre. DNA will be extracted from cheek swab samples, and selected markers will be genotyped.

Methodology. Anxiety will be assessed before and after treatment and at the 6-month follow-up. Assessment will be made dichotomously (i.e. diagnosis), and by use of questionnaire scales with both the child and parent as reporter. Furthermore, clinicians will complete a standardised improvement scale following treatment.

Analyses. Associations between genetic markers and anxiety will be considered first for all anxiety disorders as a single group, and then for each anxiety disorder sub-type individually. Comorbidity with depression and other covariates (e.g. sex) will also be considered. Associations will also be tested with respect to variation in symptom levels (i.e. is there a dose-response for the association such that two copies of a risk allele lead to even higher levels of anxiety). Associations with treatment response will be considered in terms of (a) presence/absence of disorder, (b) change in symptom level and (c) clinical rating of improvement. Again, important covariates such as age, sex, symptoms severity, and parental mental health will also be considered.

Scientific and medical opportunities. This programme of research provides the opportunity to collect a unique dataset that will have implications for understanding both the development and treatment of child anxiety. The possibility of predicting treatment outcomes and thus tailoring treatments for children with anxiety disorders is highly valuable in both financial and human cost terms.

Publications

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Brown HM (2013) Attentional threat avoidance and familial risk are independently associated with childhood anxiety disorders. in Journal of child psychology and psychiatry, and allied disciplines

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Coleman JR (2017) Separate and combined effects of genetic variants and pre-treatment whole blood gene expression on response to exposure-based cognitive behavioural therapy for anxiety disorders. in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

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Coleman JR (2016) Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders. in The British journal of psychiatry : the journal of mental science

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Coleman JRI (2017) Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

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Craske M (2017) Anxiety disorders in Nature Reviews Disease Primers

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Hudson JL (2015) Clinical Predictors of Response to Cognitive-Behavioral Therapy in Pediatric Anxiety Disorders: The Genes for Treatment (GxT) Study. in Journal of the American Academy of Child and Adolescent Psychiatry

 
Description Attention Bias Modification (ABM): Development and testing of a school-based "Cognitive Vaccine" for the reduction and prevention of child anxiety
Amount £238,927 (GBP)
Funding ID MR/J011762/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2012 
End 09/2014
 
Description Australian Research Council Linkage Grant
Amount $341,484 (AUD)
Funding ID LP130100576 
Organisation Australian Research Council 
Sector Public
Country Australia
Start 07/2013 
End 06/2016
 
Description BRC Travel award to attend and present research at World Congress of Psychiatric Genetics
Amount £1,000 (GBP)
Organisation King's College London 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start  
 
Description BRC funding to extract parental DNA samples
Amount £36,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2010 
End 09/2012
 
Description ESRC LISS DTP Case Studentship
Amount £100,000 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 10/2018 
End 10/2022
 
Description ESRC LISS DTP Case Studentship - Exploring social factors in the psychological treatment of anxiety and mood disorders
Amount £71,000 (GBP)
Funding ID 2105614 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 10/2017 
End 10/2021
 
Description Fondation Peters Studentship bid
Amount £140,000 (GBP)
Organisation King's College London 
Department Fondation Peters, King's College London
Sector Charity/Non Profit
Country United Kingdom
Start 10/2015 
End 10/2019
 
Description Genetics Society's Junior Scientist Travel Grant
Amount £662 (GBP)
Organisation The Genetics Society 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Genome-wide Association Studies of Anxiety Spectrum Phenotypes: Furthering the PGC Anxiety Disorders Working Group.
Amount £21,105 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 07/2018 
End 05/2019
 
Description International Study of Genetic Factors in Exposure Treatments of Anxiety Disorders.
Amount £301,248 (GBP)
Organisation Alexander von Humboldt Foundation 
Sector Public
Country Germany
Start 09/2011 
End 09/2017
 
Description Jacobs Foundation Young Researcher Grant
Amount £25,970 (GBP)
Organisation Jacobs Foundation 
Sector Charity/Non Profit
Country Switzerland
Start  
 
Description MRC Centenary Early Career Award
Amount £80,000 (GBP)
Funding ID G0901874 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2012 
End 08/2013
 
Description MRC Clinical Research Training Fellowship - The role of parental factors in the development and treatment of paediatric obsessive-compulsive disorder
Amount £294,798 (GBP)
Funding ID MR/N001400/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2016 
End 06/2019
 
Description MRC Population Health Scientist Fellowship
Amount £270,776 (GBP)
Funding ID MR/K021281/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2013 
End 07/2016
 
Description MRC travel grant: Medical Research Foundation to make awards to support the conference and travel costs of someone in the MRC SGDP Centre working on research for depression or a related condition in children.
Amount £985 (GBP)
Funding ID C0328 
Organisation Medical Research Council (MRC) 
Department Medical Research Foundation
Sector Charity/Non Profit
Country United Kingdom
Start 10/2011 
End 09/2013
 
Description NIHR Special Award (UK National Mental Health Biobank)
Amount £430,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 08/2019 
End 04/2022
 
Description UK National Mental Health Biobank
Amount £1,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2018 
End 03/2019
 
Description Understanding genetic and environmental risks of emotional disorders in childhood and adolescence.
Amount $794,124 (AUD)
Funding ID G0901874 
Organisation Australian Research Council 
Sector Public
Country Australia
Start 07/2012 
End 07/2016
 
Title GxT DNA samples 
Description DNA samples from over 2000 children participating in the GxT study. Data collection is ongoing so the numbers will increase. 
Type Of Material Biological samples 
Year Produced 2014 
Provided To Others? No  
Impact Our first publication came out on 25.10.11 in Molecular Psychiatry. All publications and talks that are linked to the grant G0901874 on ResearchFish are notable impacts resulting from these samples. 
 
Title Genes for Treatment study dataset 
Description We have collected DNA and data on 2,000 children with anxiety disorders undergoing cognitive behaviour therapy. 
Type Of Material Database/Collection of data 
Year Produced 2012 
Provided To Others? Yes  
Impact Please see publications listed against this award. This stud/research has led to a whole new area of research work in my group, which is indicated by the subsequent awards/funding and collaborations. 
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation Columbia University
Country United States 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation Creighton University
Country United States 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation Hunter College
Country United States 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation McLean Hospital
Country United States 
Sector Hospitals 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation National Institutes of Health (NIH)
Department National Institute of Mental Health (NIMH)
Country United States 
Sector Public 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation NewYork-Presbyterian Hospital
Country United States 
Sector Hospitals 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation Penn State University
Country United States 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation Tel Aviv University
Department Psychology Department (TAU)
Country Israel 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation Tel Aviv University
Department Psychology Department (TAU)
Country Israel 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation University College Dublin
Department School of Psychology
Country Ireland 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation University of California, San Francisco
Country United States 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation University of Colorado Denver
Department School of Medicine Colorado
Country United States 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation University of Sao Paulo
Department OCD Spectrum Disorders Clinic
Country Brazil 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description International Study of Genetic Factors in Exposure Treatments of Anxiety Disorders 
Organisation Ruhr University Bochum
Department Faculty of Psychology
Country Germany 
Sector Academic/University 
PI Contribution I am leading the genetic aspects of this project. All DNA samples will be sent to me and all genotyping and RNA analysis will be done within my group.
Collaborator Contribution They are conducting a large study of exposure therapy in adults with phobias and have asked me to lead the genetic component of the project. I will therefore have DNA on psychological treatment response, and funding to genotype, from a large sample of adults which can complement the child sample being obtained within this grant.
Impact We are just beginning to obtain DNA samples now.
Start Year 2010
 
Description Psychiatric Genomics Consortium Anxiety Group 
Organisation Psychiatric Genomics Consortium (PGC)
Country Global 
Sector Learned Society 
PI Contribution I have initiated, along with two other colleagues (Jack Hettema and Jurgen Deckert), an anxiety group for the Psychiatric Genomics Consortium.
Collaborator Contribution The three of us co-Chair this new PGC group
Impact We are working towards our first data freeze later this year, following which we will write our first paper.
Start Year 2017
 
Description 2014 Inaugural Lecture By Prof Thalia Eley- Something old, something new: Disentangling genetic and environmental influences on anxiety and depression 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Inspired discussion among the audience after the presentation.

After the talk, I received a lot of positive feedback of the talk.
Year(s) Of Engagement Activity 2014
 
Description 2014 Pint of science festival, talk on how genetics can inform treatment choices for anxiety 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Talk inspired discussion and talk among the audience

This talk helped spread the word about how genetics can influence treatment options for anxiety
Year(s) Of Engagement Activity 2014
 
Description 2015 Invited talk (Centre for Family Research, University of Cambridge, UK) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact 2015. Genetic and environmental influences on the development and treatment of anxiety. Centre for Family Research, University of Cambridge, UK.
Year(s) Of Engagement Activity 2015
 
Description 2015 Invited talk (Department of Experimental Psychology, University of Oxford, UK) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact 2015. Genetic and environment influences on the development and treatment of anxiety. Department of Experimental Psychology, University of Oxford, UK.
Year(s) Of Engagement Activity 2015
 
Description 2015 Invited talk (Department of Psychiatry, University of Cambridge, UK) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact 2015. Genetic and environmental influences on the development and treatment of anxiety. Department of Psychiatry, University of Cambridge, UK.
Year(s) Of Engagement Activity 2015
 
Description 2015 Invited talk (University of Sussex) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Lester, K.J. (2015): Invited talk. Clinical and Developmental Research in Progress Meeting. University of Sussex.
Year(s) Of Engagement Activity 2015
 
Description 2016 Keynote Lecture (International Conferences on Child and Adolescent Psychopathology, Roehampton, UK) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2016. Keynote Lecture. Gene-environment interplay in the development and treatment of anxiety and depression. International Conferences on Child and Adolescent Psychopathology, Roehampton, UK.
Year(s) Of Engagement Activity 2016
 
Description 2016 Keynote Lecture (World Congress in Behavioural and Cognitive ETherapy, Melbourne, Australia) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2016. Keynote Lecture: How genetic research can informal clinical research and practise. World Congress in Behavioural and Cognitive ETherapy, Melbourne, Australia.
Year(s) Of Engagement Activity 2016
URL http://www.wcbct2016.com.au/program/workshops/
 
Description 2016 Keynote Lecture (Youth Mental Health day, Hotchkiss Brain Institute, University of Calgary, Canada) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 2016. Therapygenetics: Taking gene-environment interactions into the clinic. Keynote lecture within the Youth Mental Health day, Hotchkiss Brain Institute, University of Calgary, Canada.
Year(s) Of Engagement Activity 2016
 
Description BBC Radio Three Counties 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 'Nadiya: Anxiety and Me' Radio programme about the causes and treatments of anxiety.
Year(s) Of Engagement Activity 2019
URL http://www.pressdata.co.uk/ViewBroadcast.asp?a_id=18288661
 
Description Curatorial Advisor for Science Gallery London (anxiety season) King's College London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Exhibition included screens about our genetic studies of anxiety and depression
Year(s) Of Engagement Activity 2019
URL https://london.sciencegallery.com/
 
Description Gene-environment interplay in the development and treatment of anxiety and depression. International Conferences on Child and Adolescent Psychopathology, Roehampton, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 2016. Keynote Lecture. Gene-environment interplay in the development and treatment of anxiety and depression. International Conferences on Child and Adolescent Psychopathology, Roehampton, UK.
Year(s) Of Engagement Activity 2016
 
Description How genetic research can informal clinical research and practise. World Congress in Behavioural and Cognitive Therapy, Melbourne, Australia. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2016. Keynote Lecture: How genetic research can informal clinical research and practise. World Congress in Behavioural and Cognitive Therapy, Melbourne, Australia.
Year(s) Of Engagement Activity 2016
 
Description Interview - therapygenetics research programme with motherboard 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Eley is interviewed about her hopes to find genetic factors that could help advise patients on the best psychological treatment for them.
Year(s) Of Engagement Activity 2016
URL http://motherboard.vice.com/read/a-psychologist-is-trying-to-use-genetics-to-predict-if-therapy-will...
 
Description Media interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact I was interviewed by Joshua Jacobs for an article in the Financial Times about personalised treatment for anxiety and depression. Joshua found the topic quite hard but very interesting and came back to me several times for further clarifications/explanations. I have now formed a strong relationship with him and he is interesting in reporting my next major paper individually.
Year(s) Of Engagement Activity 2018
URL https://www.ft.com/content/54b53350-de73-11e7-a0d4-0944c5f49e46
 
Description Press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Unfortunately relatively little happened in response to our press release but we hope it may yet be taken up as a story linked to the new Child IAPT intiative.

None to date.
Year(s) Of Engagement Activity 2011
 
Description Radio 4 interview (All in the Mind) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I was interviewed by Claudia Hammond on All in the Mind about the role of genetics in anxiety and psychological treatment response. We focused particularly on helping parents feel less to blame for their child's anxiety.
Year(s) Of Engagement Activity 2017
URL https://www.bbc.co.uk/programmes/b08sn975
 
Description Royal College of Psychiatrists Intellectual Disability Faculty Spring Conference, London, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture about the role of genetics in the development and treatment of anxiety and depression.
Year(s) Of Engagement Activity 2019
 
Description Sapienza Lecture. Therapygenetics: Taking gene-environment interactions into the clinic. Rome, Italy. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2016. European Molecular Biology Laboratory - Sapienza Lecture. Therapygenetics: Taking gene-environment interactions into the clinic. Rome, Italy.
Year(s) Of Engagement Activity 2016
URL http://www.embl.it/research/seminars/index.php?p_outstation=MR&p_type=0&p_timeRange=2016
 
Description Senior Clinicians' Update Course: Developments in Child & Adolescent Psychiatry. UCL, London, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture about the role of genetics in the development and treatment of anxiety and depression.
Year(s) Of Engagement Activity 2019
 
Description Started a blog from my team about our work and our life as researchers 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact My team now write a blog with pieces coming out every week during term time. We cover three areas: research on emotional health; a research perspective on topics related to emotional health that are current in the media; and our lives as researchers. Our blog has become one that attracts particularly high traffic relative to other blogs at KCL. I wrote one piece last year for Children's Mental Health week on recognising how often anxiety in children masquerades as anger, and how we need to understand children's behaviours before we can treat them, which was particularly widely read. https://blogs.kcl.ac.uk/editlab/2017/02/08/mad-bad-or-sad-a-parental-perspective-on-improving-well-being-in-our-children-and-young-people/ Similarly I wrote a piece for Children's Mental Health week this year highlighting how early these disorders begin. https://blogs.kcl.ac.uk/editlab/2018/02/14/__trashed/ Within the section on our lives as researchers I have written lots of pieces for early career researchers about balancing different areas of life, finding time to write, building a team, the transition from postdoc to PI etc.
Year(s) Of Engagement Activity 2016,2017,2018
URL https://blogs.kcl.ac.uk/editlab/
 
Description Student Mental Wellbeing: Policy into Practice Event, Woburn House, London. Keynote Lecture. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Talk about the role of genetics in mental health conditions and their treatment.
Year(s) Of Engagement Activity 2019
 
Description Therapygenetics: Taking gene-environment interactions into the clinic. Keynote lecture within the Youth Mental Health day, Hotchkiss Brain Institute, University of Calgary, Canada. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2016. Therapygenetics: Taking gene-environment interactions into the clinic. Keynote lecture within the Youth Mental Health day, Hotchkiss Brain Institute, University of Calgary, Canada.
Year(s) Of Engagement Activity 2016
 
Description Therapygenetics: how genes influence psychological treatment. Stockholm, Sweden 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2017 Karolinksa Institutet - Stockholm Psychiatry Lecture. Therapygenetics: how genes influence psychological treatment. Stockholm, Sweden
Year(s) Of Engagement Activity 2017
URL https://www.facebook.com/events/1412617172090328/