MRC Network of UK Brain Banks: Support for the Coordinating Centre

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Molecular. Genetics & Pop Health

Abstract

The UK is facing a major challenge to health services, carers and the economy in dealing with the increasing numbers of individuals who are suffering from progressive neurological diseases such as Alzheimer?s disease and Parkinson?s disease. As the population ages, increasing numbers of individuals are likely to develop these diseases and this places a high priority on improving our knowledge of these diseases, the mechanisms through which the brain is damaged, and identifying new opportunities for treatment and for better diagnostic tests in living patients. The aim of the Network of UK brain banks is to support this vital research by making brain tissue samples of the highest quality available to researchers in the UK. The Network will also address the shortage of normal tissue samples that are required as control material for the disease tissue samples. The Network will allow its members to work together in a more co-ordinated way, resulting in a more flexible and cost-efficient operation. The benefits of the Network for researchers will also be increased by creating a website that allows easy access to information on the nature and type of brain tissue samples stored in the various banks across the UK. The Network will also use the website to provide new information to potential brain tissue donors, and will direct these towards the most appropriate donor scheme operating at one of the banks in the Network. This project will therefore enable more research, not just into Alzheimer?s disease but into a wider range of neurological and neuropsychiatric diseases, such as motor neurone disease and schizophrenia. These devastating disorders represent a major challenge for 21st century health care and have been identified as a priority area for the NHS. This Network will support the excellent research already being undertaken in the UK, and allow it to develop further at a faster rate than currently is possible. The Network will also provide a focus for the general public in understanding more about brain tissue donation, and this increased awareness will also help support research in the UK.

Technical Summary

This application seeks to secure support for the co-ordinating centre for the MRC Network of Brain Banks in the UK. This MRC initiative is designed to facilitate research into human neurological and psychiatric diseases by ensuring uniformly high standards of operation and the collection of samples fit for the purposes of 21st century science. The Network will also address the current shortage of control brain tissue samples, initially by facilitating exchange and use of current samples, and later by seeking to develop additional means of collection. The Network will develop a database and web site; the database will contain data from existing UK brain banks in order to allow researchers to identify whether samples required for their research are available and to quickly locate the most appropriate source. This data are very large (thousands of tissue samples) and complex in terms of information on clinical and pathological features, the anatomical regions of the brain sampled and the formats for storage. The construction of a searchable database that will include this complex data will require substantial input from a full time database manager, with additional programming support. The website will also contain information for potential donors and will facilitate donation by directing potential donors to the most appropriate banks for further information and registration. The Network Director runs the co-ordinating centre and will be responsible for the work of the support staff ? a database manager and a part-time personal assistant, essential for supporting the Director and acing as Network co-ordinator. The activities of the Network will be overseen by a Steering Group, and work of the Network will be informed by a scientific users group to ensure that the material collected and stored is suitable for the diverse scientific needs of researchers. A Management Group comprising the principal investigators from each bank will function as an operational body to agree and develop standards of operation on tissue sampling, storage, analysis and labelling, and ethics and governance mechanisms. The Network will support research in the UK funded not only by the MRC, but by other funding bodies and charities, in order to advance understanding of common neurodegenerative disorders and neuropsychiatric diseases that place an enormous burden on patients, their carers and the National Health Service. The co-ordinating centre is a key component of the Network and will act as a focal contact point for scientists, media and the public alike.

Publications

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Fairfoul G (2016) Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies. in Annals of clinical and translational neurology

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Giaccone G (2011) New lexicon and criteria for the diagnosis of Alzheimer's disease. in The Lancet. Neurology

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Klioueva NM (2015) BrainNet Europe's Code of Conduct for brain banking. in Journal of neural transmission (Vienna, Austria : 1996)

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Kovacs GG (2017) Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). in Journal of neuropathology and experimental neurology

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Peden AH (2012) Molecular pathology in neurodegenerative diseases. in Current drug targets

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Samarasekera N (2013) Brain banking for neurological disorders. in The Lancet. Neurology

 
Title MRC UK Brain Bank Network Database 
Description Construction of a common database in a format to allow researchers access to information on which type of brain tissue samples are available for research use, where the samples are held and how to access them. This will be in a web-based format and will be hoted on the MRC website. Data collection and database construction is currently in progress. 
Type Of Material Improvements to research infrastructure 
Year Produced 2009 
Provided To Others? Yes  
Impact Use of human brain tissue in neuroscience research in UK. 
URL https://www.mrc.ac.uk/research/facilities-and-resources-for-researchers/brain-banks/how-to-access-br...
 
Description MRC Network of UK Brain Banks 
Organisation Cambridge University Hospitals NHS Foundation Trust
Department Cambridge Brain Bank
Country United Kingdom 
Sector Public 
PI Contribution I have created a Network of Brain Banks in the UK, involving 10 different centres, to imrpove the standards of operation and to increase the use of huuman brain tissue in Neuroscience research
Collaborator Contribution Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.
Impact Creation of a Network with a Steering Committee, Management group, Users Group and Website. Interface with other UK funders of brain banks including Parkinson's UK, the Multiple Sclerosis Society, the Alzheimer Society and the Alzheimer Research Trust.
Start Year 2009
 
Description MRC Network of UK Brain Banks 
Organisation Imperial College London
Department Multiple Sclerosis and Parkinson's Tissue Bank
Country United Kingdom 
Sector Academic/University 
PI Contribution I have created a Network of Brain Banks in the UK, involving 10 different centres, to imrpove the standards of operation and to increase the use of huuman brain tissue in Neuroscience research
Collaborator Contribution Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.
Impact Creation of a Network with a Steering Committee, Management group, Users Group and Website. Interface with other UK funders of brain banks including Parkinson's UK, the Multiple Sclerosis Society, the Alzheimer Society and the Alzheimer Research Trust.
Start Year 2009
 
Description MRC Network of UK Brain Banks 
Organisation King's College London
Department Institute of Psychiatry, Psychology & Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution I have created a Network of Brain Banks in the UK, involving 10 different centres, to imrpove the standards of operation and to increase the use of huuman brain tissue in Neuroscience research
Collaborator Contribution Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.
Impact Creation of a Network with a Steering Committee, Management group, Users Group and Website. Interface with other UK funders of brain banks including Parkinson's UK, the Multiple Sclerosis Society, the Alzheimer Society and the Alzheimer Research Trust.
Start Year 2009
 
Description MRC Network of UK Brain Banks 
Organisation Newcastle University
Department Institute for Ageing and Health
Country United Kingdom 
Sector Academic/University 
PI Contribution I have created a Network of Brain Banks in the UK, involving 10 different centres, to imrpove the standards of operation and to increase the use of huuman brain tissue in Neuroscience research
Collaborator Contribution Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.
Impact Creation of a Network with a Steering Committee, Management group, Users Group and Website. Interface with other UK funders of brain banks including Parkinson's UK, the Multiple Sclerosis Society, the Alzheimer Society and the Alzheimer Research Trust.
Start Year 2009
 
Description MRC Network of UK Brain Banks 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution I have created a Network of Brain Banks in the UK, involving 10 different centres, to imrpove the standards of operation and to increase the use of huuman brain tissue in Neuroscience research
Collaborator Contribution Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.
Impact Creation of a Network with a Steering Committee, Management group, Users Group and Website. Interface with other UK funders of brain banks including Parkinson's UK, the Multiple Sclerosis Society, the Alzheimer Society and the Alzheimer Research Trust.
Start Year 2009
 
Description MRC Network of UK Brain Banks 
Organisation University of Bristol
Department School of Clinical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution I have created a Network of Brain Banks in the UK, involving 10 different centres, to imrpove the standards of operation and to increase the use of huuman brain tissue in Neuroscience research
Collaborator Contribution Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.
Impact Creation of a Network with a Steering Committee, Management group, Users Group and Website. Interface with other UK funders of brain banks including Parkinson's UK, the Multiple Sclerosis Society, the Alzheimer Society and the Alzheimer Research Trust.
Start Year 2009
 
Description MRC Network of UK Brain Banks 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution I have created a Network of Brain Banks in the UK, involving 10 different centres, to imrpove the standards of operation and to increase the use of huuman brain tissue in Neuroscience research
Collaborator Contribution Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.
Impact Creation of a Network with a Steering Committee, Management group, Users Group and Website. Interface with other UK funders of brain banks including Parkinson's UK, the Multiple Sclerosis Society, the Alzheimer Society and the Alzheimer Research Trust.
Start Year 2009
 
Description MRC Network of UK Brain Banks 
Organisation University of Manchester
Department Community-Based Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution I have created a Network of Brain Banks in the UK, involving 10 different centres, to imrpove the standards of operation and to increase the use of huuman brain tissue in Neuroscience research
Collaborator Contribution Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.
Impact Creation of a Network with a Steering Committee, Management group, Users Group and Website. Interface with other UK funders of brain banks including Parkinson's UK, the Multiple Sclerosis Society, the Alzheimer Society and the Alzheimer Research Trust.
Start Year 2009
 
Description MRC Network of UK Brain Banks 
Organisation University of Oxford
Department Oxford Centre for Human Brain Activity (OHBA)
Country United Kingdom 
Sector Academic/University 
PI Contribution I have created a Network of Brain Banks in the UK, involving 10 different centres, to imrpove the standards of operation and to increase the use of huuman brain tissue in Neuroscience research
Collaborator Contribution Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.
Impact Creation of a Network with a Steering Committee, Management group, Users Group and Website. Interface with other UK funders of brain banks including Parkinson's UK, the Multiple Sclerosis Society, the Alzheimer Society and the Alzheimer Research Trust.
Start Year 2009
 
Description MRC Network of UK Brain Banks 
Organisation University of Sheffield
Department Department of Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution I have created a Network of Brain Banks in the UK, involving 10 different centres, to imrpove the standards of operation and to increase the use of huuman brain tissue in Neuroscience research
Collaborator Contribution Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.Collaboration in Network activities.
Impact Creation of a Network with a Steering Committee, Management group, Users Group and Website. Interface with other UK funders of brain banks including Parkinson's UK, the Multiple Sclerosis Society, the Alzheimer Society and the Alzheimer Research Trust.
Start Year 2009
 
Description Brain banking Event, Edinburgh Science Festival 2010 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 85 members of the publci attended an interactive event with presentations and discussion and voting on questions on the toipic "What shoudl happen to your brain when you die"? in relation to research into neurological diseases.

Heightened awareness of brain donation for research in Scotland
Year(s) Of Engagement Activity 2010