Antisocial behaviour in young people with ADHD: Identifying risk pathways

Lead Research Organisation: Cardiff University
Department Name: School of Medicine

Abstract

Antisocial behaviour is a major clinical and societal problem. However, there are many different types and causes of antisocial behaviour. One subgroup of children that shows very poor outcomes in adult life consists of children who show antisocial behaviour in childhood accompanied by problems with inattention, hyperactivity and impulsiveness (ADHD). Although inherited, family and social factors all contribute to antisocial behaviour, inherited factors seem to be especially important for this subgroup. Interestingly, a gene variant that affects a brain enzyme called COMT has been found to be associated with antisocial behaviour in this subgroup of children. Usually, there is a need to be cautious about such findings, but this link has now been reported in 5 different samples across the world. It is therefore time to understand how this gene affects this subgroup of antisocial children so we can get clues for better types of treatment. Unfortunately, existing treatments for these children do not seem to work in the longer term. We have some ideas as to how this gene might increase risk, because it has been linked to brain function and emotions in normal individuals. Some exploratory work that we have done suggests that reduced reaction to emotional stimuli might be important. However, to accurately test this we need to ask affected children to come into our laboratory so we can properly measure emotions and brain function by seeing how well these children do on specific tasks. The aim of this proposal is to test 274 male adolescents with ADHD to examine whether the COMT gene variant increases the risk of early onset antisocial behaviour through emotional or affective pathways. We will set the study up in such a way that once we have results, we will also be able to undertake research involving brain imaging to find out in a more direct way what happens in the brains of those affected.

Technical Summary

Childhood-onset conduct disorder (CD) problems accompanied by ADHD (Attention Deficit Hyperactivity Disorder) are clinically important because this subgroup shows greater clinical severity and worse outcomes than when either problem presents alone. CD problems are clinically and aetiologically heterogeneous, and influenced by both genetic and environmental risk factors. Family and twin studies show that inherited factors appear to be especially important for this subgroup. Five studies (3 UK, 1 New Zealand, 1 USA) and a pooled analysis have now found association between a gene variant affecting COMT enzyme activity and CD problems in those with ADHD. This relationship is not observed for CD alone or ADHD alone. There is now a need to move beyond simply observing association to testing likely risk mechanisms. Studies of normal individuals, those with CD and our own pilot work suggest that impaired affective response is an important link on the risk pathway, but this needs to be properly tested because executive functioning deficits might also contribute. Why is identifying risk pathways important? Despite ADHD being the most common reason for Child Mental Health Service follow-up, currently used treatment strategies (medication and behavioural treatment) appear to have limited long-term effectiveness on CD outcomes. There is thus a pressing need to identify appropriate targets for new types of psychological and pharmacological treatment. The aim of this proposal is to build on existing genetic and cognitive evidence and identify risk pathways that contribute to conduct problems in ADHD and targets for future intervention strategies. Specifically, we propose to capitalise on an existing sample of 274 clinically well-characterised adolescents with ADHD, who have been genotyped for the COMT risk variant, and to undertake laboratory testing of their cognitive function, affective response and associated psychophysiological reactivity. This is to test the hypothesis that impaired affective response is an intermediate phenotype that mediates the links between the COMT risk genotype and CD problems. Because different genetic and environmental risk factors could impact on similar risk pathways, we will also examine whether this intermediate phenotype distinguishes between those with and without CD problems regardless of genotype. The results of this study will enable us to undertake future research involving brain imaging to better understand how specific neurocognitive vulnerabilities may characterize different subtypes of children with antisocial behaviour.

Publications

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Agha SS (2017) Parent Psychopathology and Neurocognitive Functioning in Children With ADHD. in Journal of attention disorders

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Eyre O (2017) Irritability in ADHD: Associations with depression liability. in Journal of affective disorders

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Hubble K (2017) Oxytocin Reduces Face Processing Time but Leaves Recognition Accuracy and Eye-Gaze Unaffected. in Journal of the International Neuropsychological Society : JINS

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Martin J (2014) Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. in Journal of the American Academy of Child and Adolescent Psychiatry

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Martin J (2014) Factor structure of autistic traits in children with ADHD. in Journal of autism and developmental disorders

 
Description Appointed member of National Institute for Health Research Development of a Ten Year Strategy for Mental Health - Children and Young People
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL https://www.gov.uk/government/publications/a-framework-for-mental-health-research
 
Description British Association of Psychopharmacology
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Generating ADHD evidence
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Member of Welsh Assembly Government and CAMHS Together for Children and Young People Expert Reference Group
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Paper (2016) Thapar A, Cooper M, Rutter M, Neurodevelopmental Disorders: a personal view, The Lancet Psychiatry [Epub ahead of print]
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Paper in Archives of Disease in Childhood entitled "What causes attention deficit hyperactivity disorder?"
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Paper in Child Psychology Psychiatry entitled "What have we learnt about the causes of ADHD?"
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Paper in The Lancet entitled "Attention Deficit Hyperactivity Disorder" [In Press] 2016
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Rutter's child and adolescent pyschiatry textbook
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Speaking at the Together for Children and Young People Conference, Cardiff, 22 June 2015
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Neurodevelopmental Disorders: What happens when children grow up and why?
Amount £893,353 (GBP)
Funding ID 204895/Z/16/ZI 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2017 
End 01/2021
 
Description ADHD genetics 
Organisation Psychiatric GWAS Consortium (PGC)
Department ADHD Sub Group
Country United States 
Sector Academic/University 
PI Contribution joint papers, samples
Collaborator Contribution joint papers
Impact papers published
Start Year 2007
 
Description Child and Adolescent Research 
Organisation University of Sussex
Department School of Psychology Sussex
Country United Kingdom 
Sector Academic/University 
PI Contribution scientific input to design of grant and ongoing papers
Collaborator Contribution scientific input to design of grant and ongoing papers
Impact Multiple papers
Start Year 2013
 
Description Exome sequencing 
Organisation University of California, San Francisco
Department School of Medicine (UCSF)
Country United States 
Sector Academic/University 
PI Contribution Scientific collaboration-we collected ADHD samples and will provide intellectual input on ADHD
Collaborator Contribution They have funding to exome sequence trios
Impact None yet
Start Year 2018
 
Description PGC 
Organisation Psychiatric GWAS Consortium (PGC)
Country Global 
Sector Academic/University 
PI Contribution We contribute to the international Psychiatric Genetics Consortium PGC-data, analysis, initating new papers and helping with co-ordination. AThapar was the ADHD representative for the Cross Disorders Group for 2 years. We remain active contributors to the PGC ADHD group
Collaborator Contribution PGC involves the largest world wide psychiatric genetics collaboration and data set. This allows us access to the data set for hypothesis generation
Impact Research papers as recorded under publications. PhD studentship data.
Start Year 2008
 
Description PGC 
Organisation Psychiatric GWAS Consortium (PGC)
Country Global 
Sector Academic/University 
PI Contribution We contribute to the international Psychiatric Genetics Consortium PGC-data, analysis, initating new papers and helping with co-ordination. AThapar was the ADHD representative for the Cross Disorders Group for 2 years. We remain active contributors to the PGC ADHD group
Collaborator Contribution PGC involves the largest world wide psychiatric genetics collaboration and data set. This allows us access to the data set for hypothesis generation
Impact Research papers as recorded under publications. PhD studentship data.
Start Year 2008
 
Description Rutter text book 
Organisation National Institutes of Health (NIH)
Department National Institute of Mental Health (NIMH)
Country United States 
Sector Public 
PI Contribution Lead editor of the Rutter text book
Collaborator Contribution co lead editor of the Rutter text book
Impact The Rutter text book was published in 2015
Start Year 2012
 
Description 2014 Brain & Behavior Research Foundation Ruane Prize for Child and Adolescent Psychiatry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Education and Information
Year(s) Of Engagement Activity 2014
URL http://youtu.be/1k82NwFc2_Y
 
Description 6ADHD Genetic findings: What do they mean for clinical practice 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact ADHD Genetic findings: What do they mean for clinical practice - RcPsych - International Meeting - Liverpool, July 13 2012 - for Practitioners

unknown
Year(s) Of Engagement Activity 2012
 
Description ADHD Open Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact An event for the public to learn more about ADHD, latest findings and how parents and their families can help with research. Adult attendees were 98% satisfied with the event and there was a likelihood of 87% that they would take part in future research studies. 21.4% of the child attendees said the event was great fun, 21.4% said it was quite good and 57.1% said it was ok.
Year(s) Of Engagement Activity 2016
 
Description Advances in Genetics Research in ADHD 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact Advances in Genetics Research in ADHD - Dyscovery Centre - Newport - February 2012 for Practitioners

unknown
Year(s) Of Engagement Activity 2012
 
Description Advances in Genetics Research in ADHD 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact Advances in Genetics Research in ADHD - Child and Adolescent Group - Oxford for Practitioners

unknown
Year(s) Of Engagement Activity 2012
 
Description BNA Festival of Neuroscience 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact BNA Festival of Neuroscience - Barbican, London - Neurodevelopment and neuorgentics of ADHD within the symposium entitled Neuropsychiatry research in the 21st Century.

Increased awareness of ADHD
Year(s) Of Engagement Activity 2013
 
Description CALPDN Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Delivered a talk about Neurodevelopmental Disorders at the CALPDN Conference

Unknown
Year(s) Of Engagement Activity 2014
 
Description CAMHS Network Training Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Gave a talk about Tourette's Syndrome at the CAMHS Network Training Day

Unknown
Year(s) Of Engagement Activity 2014
 
Description Cardiff Univeristy Lab Talk - 26 January 2016 - Attention Deficit Hyperactivity Disorder: a developmental journey 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Talk to the Cardiff University MRC Centre staff and students - approximately 70 people attended with discussion time.
Year(s) Of Engagement Activity 2016
 
Description Cardiff University ADHD Day held on 28.10.2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Approximately 60 people attended an afternoon of talks and workshops to provide information and support to individuals and families with ADHD.
Year(s) Of Engagement Activity 2016
URL http://www.ncmh.info/2016/11/07/adhd-open-day-for-families-a-success/
 
Description Cardiff University Science in Health Public Lecture Talk given on Attention Deficit Hyperactivity Disorder: separating facts from fiction 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk given to school children, general public and undergraduates to inform on ADHD
Year(s) Of Engagement Activity 2014
URL http://ncmh.info/videos/adhd-facts-fiction/
 
Description Challenge Cardiff Magazine Interview and video 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact To inform and educate
Year(s) Of Engagement Activity 2015
URL https://youtu.be/OSBdjgNDAHE
 
Description Clinical Academic Showcase at Bristol University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Clinical Academic Showcase organised jointly by University of Bristol and NHS Health Education England, Severn Postgraduate Medical Education. Talk by Anita Thapar entitled Attention Deficit Hyperactivity Disorder: a Developmental Journey as a Clinical Academic.
Year(s) Of Engagement Activity 2017
 
Description Developmental Disorders - Cardiff University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Developmental Disorders - Cardiff University - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics - Departmental Retreat - June 2012 - for (Academics, students and staff.)

unknown
Year(s) Of Engagement Activity 2012
 
Description ESCR Festival: Debate 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact An event for schools to discuss psycho-social research into mental health disorders and how this relates to biological approaches.
Year(s) Of Engagement Activity 2016
 
Description Eunethydis Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Delivered a talk at the Eunethydis Conference entitled The origins of conduct problems in ADHD - causes and clinical implications

Unknown
Year(s) Of Engagement Activity 2014
 
Description Eunethydis Conference, Prague 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Delivered a talk on ADHD at the Eunethydis Conference, Prague

Unknown
Year(s) Of Engagement Activity 2013
 
Description Gene environment designs - Aarhus University, Denmark 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact Gene environment designs - Aarhus University, Denmark - 8 November 2012 for Researchers

unknown
Year(s) Of Engagement Activity 2012
 
Description Genetics Talk to SpRs 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Delivered a talk to SPRs on Genetics

Increased awareness of ADHD
Year(s) Of Engagement Activity 2012
 
Description Genetics and Child Psychiatry - ADHD as an Illustration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Genetics and Child Psychiatry - ADHD as an Illustration - CPRS 40th Anniversary 11th May 2012 - for National Research

unknown
Year(s) Of Engagement Activity 2012
 
Description Giving talk at South Staffordshire & Shropshire Healthcare NHS as part of the National Speaker Programme on 20 November 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A talk entitled "Attention Deficit Hyperactivity Disorder: what do research findings mean for clinical practice?" The audience comprised mainly medical students, trainees in psychiatry, SAS doctors and consultant staff from both general and specialities in psychiatry.
Year(s) Of Engagement Activity 2014
 
Description Giving talk on "ADHD: What next?" at the Royal College of Psychiatrists in Wales Faculty of Child & Adolescent Psychiatry meeting in Wales on 29 April 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Talk to clinical practitioner members of the Royal College of Psychiatrists in Wales Faculty of Child & Adolescent Psychiatry to discuss research into ADHD
Year(s) Of Engagement Activity 2016
 
Description ISPG Conference, Hamburg 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A shared polygenic contribution between ADHD and schizophrenia - ISPG Conference, Hamburg - October 20-12 for International Researchers


unknown
Year(s) Of Engagement Activity 2012
 
Description Interview for British Medical Journal - BMJ Careers Role Model feature 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Telephone interview with journalist from the British Medical Journal . Every four weeks they interview a doctor who has been nominated as a role model by another doctor. The article focuses on a doctor's career to date, their inspirations, motivations and highs and lows. It's meant to inspire others.
Year(s) Of Engagement Activity 2017
 
Description Introduction at Preventing Adolescent Depression: Starting Early in Schools, Communities and Primary Care 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Introduction at Preventing Adolescent Depression: Starting Early in Schools, Communities and Primary Care - All Nations Centre - 17 July 2012 - for Practitioners and Policy Makers

unknown
Year(s) Of Engagement Activity 2012
 
Description Last Chance Saloon (Part 6) - a series of short documentaries created by the Wellcome Trust in collaboration with NCMH 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Video interview with Neil "Twink" Tinning, formerly the official photographer for 1980s mod band The Jam, as he embarks on a year-long journey to understand mental illness while recording an album and performing live for the first time with his own band.
Year(s) Of Engagement Activity 2012
URL http://ncmh.info/videos/last-chance-saloon/
 
Description MRC Brain disorders summer school 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk titled 'Developmental disorders - child and adolescent psychiatry'. 83% of delegates rated the summer school as 'very good', with 100% saying they would recommend it to others.
Year(s) Of Engagement Activity 2016
URL http://www.cardiff.ac.uk/mrc-centre-neuropsychiatric-genetics-genomics/study/summer-school
 
Description NCMH Piece of Mind Podcast on ADHD 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Pod cast discussion with Anita Thapar and Zoe Piper of ADHD Connections Bridgend about ADHD, their relative experience as a researcher working on ADHD and as someone who has direct experience of ADHD. They talk about the science behind psychiatry, as well as somebody with lived experience of a mental health problem to bring a real-life perspective.
By combining people's personal experiences of mental health with an overview of the latest research in the field, Piece of Mind aims to help tackle stigma and encourage more people to get involved in research.
Year(s) Of Engagement Activity 2017
URL https://www.cardiff.ac.uk/mrc-centre-neuropsychiatric-genetics-genomics/get-involved/public-engageme...
 
Description Podcast: Piece of Mind 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interviewed for podcast on ADHD, along with a patient and past research participant
Year(s) Of Engagement Activity 2018
URL https://soundcloud.com/pieceofmindpodcast/adhd
 
Description Public lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Over 100 general public members and also 6th formers
I gave a talk on ADHD and myths- this is now provided on a web site and available for download.
I met with 8 sixth formers beforehand to discuss a career in clinical academic medicine

A patient support group wants to help with research and disseminate findings.
Year(s) Of Engagement Activity 2014
 
Description RCPsych Conf 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Delivered a talk entitled Current Research and Reflections on Child Psychiatry at the RCPsych Conference

Unknown
Year(s) Of Engagement Activity 2014
 
Description Research Features article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on "Identifying the impact of neuropsychiatric genetic risk scores in childhood - an insight"
Year(s) Of Engagement Activity 2017
 
Description Rudd Centre, Sussex 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Delivered a talk entitled Genes, Environment and Interplay at the Rudd Centre, Sussex

Unknown
Year(s) Of Engagement Activity 2014
 
Description St David's Day Lecture at Royal College of Paediatricians and Child Health (Wales) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Delivered a talk at the St David's Day Lecture at Royal College of Paediatricians and Child Health (Wales) St David's Day Trainee Conference Research Symposium - Radisson Blu Hotel, Cardiff

Increased awareness of ADHD
Year(s) Of Engagement Activity 2013
 
Description Summer School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Delivered a talk entitled Developmental Disorders / Child and Adolescent Psychiatry to MRC CNGG Summer School Participants

Unknown
Year(s) Of Engagement Activity 2010,2014,2015
 
Description Talk at ADHD event organised by Cardiff and Vale Parents' Federation, 24 February 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk entitled "What do we know about ADHD" given by Sharifah Syed to inform and educate
Year(s) Of Engagement Activity 2016
 
Description Talk at Cardiff University Summer School on 12 July 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Talk by Prof Thapar to 60 delegates of the Cardiff University Summer School on Developmental Disorders/Child & Adolescent Psychiatry
Year(s) Of Engagement Activity 2016
 
Description Talk at D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil on 24.11.2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk on the subject of ADHD: a developmental journey. A talk given to physicians (neurologists, psychiatrists and other specialities), psychologists, speech therapists and some PhD students from all areas. Followed by a discussion with the audience.
Year(s) Of Engagement Activity 2016
 
Description Talk at the XIV ProDAH Meeting at the University of Rio Grande Do Sul in Porto Alegre, Brazil on 25.11.2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk on ADHD: a developmental journey given to a mix of mater degree, doctoral degree and post-doc students, Professors and clinical instructors of psychiatry and genetics, including students of genetics.
Joint grant (Wellcome Trust) and joint paper.
Year(s) Of Engagement Activity 2016
 
Description Talk to Educational Psychology Students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Delivered a talk entitled "The genetic basis of Attention Deficit Hyperactivity Disorder - where next in neuroscience?" to Educational Psychology Students

Unknown
Year(s) Of Engagement Activity 2013
 
Description Talk to the Child Psychiatry Research Society on 6 May 2016 on Neurodevelopmental disorders: what happens when children grow up and why? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Approximately 30 members of the CPRS attended the meeting where new research activity was presented followed by a discussion. Talks also presented by three other members of the Cardiff University Child and Adolescent Group - Miriam Cooper, Olga Eyre and Rhys Bevan-Jones.
Year(s) Of Engagement Activity 2016
 
Description The genetic basis of attention Deficit Hyperactivity Disorder where next in Neuroscience? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Undergraduate Teaching - The genetic basis of attention Deficit Hyperactivity

unknown
Year(s) Of Engagement Activity 2011
 
Description WT and NMHR Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Delivered a talk to Wellcome Trust Students

Increased awareness of ADHD
Year(s) Of Engagement Activity 2012
 
Description Wales Online 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Zoe shares ADHD story, Prof Thapar comments
Year(s) Of Engagement Activity 2015,2016
URL http://www.walesonline.co.uk/news/health/mum-explains-what-its-like-11924647
 
Description Wellcome Trust PhD Training 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Delivered a talk on Childhood Disorders to the Wellcome Trust PhD Students from the NMHRI

Unknown
Year(s) Of Engagement Activity 2013
 
Description Western Mail and Echo 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact HCW: Zoe Piper on ADHD, Prof Anita Thapar comments
Year(s) Of Engagement Activity 2016
 
Description european adhd network meeting eunethydes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Provided a talk at the european adhd network meeting eunethydes

Unknown
Year(s) Of Engagement Activity 2013
 
Description medicalresearch.com 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Dr Lucy Riglin interviewed about research into Genetic Predisposition To Schizophrenia Associated With Childhood Impairments
Year(s) Of Engagement Activity 2016
URL https://medicalresearch.com/author-interviews/genetic-predisposition-to-schizophrenia-associated-wit...
 
Description new research which suggests that inner-ear problems could be a cause of hyperactive behaviour 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Professor Anita Thaper, School of Medicine comments on new research which suggests that inner-ear problems could be a cause of hyperactive behaviour. (BBC Online, 06.09.13)

Unknown
Year(s) Of Engagement Activity 2013
URL http://www.bbc.co.uk/news/health-23972137