Brain white matter imaging and cognitive ageing in the Lothian Birth Cohort of 1936: II

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Philosophy Psychology & Language

Abstract

There are more old people in our population, and they also make up a greater proportion of the society than previously. Losing thinking skills (cognitive functions) is the most feared aspect of growing older. Loss of cognitive functions is the cause for 40% of admissions to institutional care in the UK. There is a lot of research on different types of dementia. However, a larger problem?because it affects so many more people?is milder states of mental decline. Age itself has a detrimental effect on important mental skills, such as memory, reasoning, speed of thinking, and the organisation of thinking. Losing such skills has a serious detrimental effect on people?s everyday lives, lowers their quality of living, and heralds dementia and death. We do not yet know all the factors that make some people?s thinking skills hold up better with age than others?, but it is important to find out. We have a unique and time-limited opportunity to address this question. We are carrying out a large research project called The Disconnected Mind, of which the charity Age UK is the core supporter. The sample of human subjects in the Disconnected Mind is the Lothian Birth Cohort 1936 (LBC1936). They were all born in 1936. They took part in a Scottish national survey of intelligence at age 11; therefore, crucially, we know their cognitive skills from childhood. At age 70, they took a large numbers of different types of cognitive testing, and they underwent detailed medical and blood testing, and lifestyle questionnaires. We have published many scientific studies on their changes in cognition from age 11 to age 70. At age 73 they took all these cognitive and medical tests again. In addition, they also took a very detailed magnetic resonance imaging brain scan that concentrated on the brain?s connections: the whiter matter of the brain. Results are starting to emerge (we have only just finished taking the 725+ brain scans) which make it clear that: changes in the brain?s white matter are one of the key contributors to age-related cognitive decline; and intelligence from childhood is a significant contributor to the state of the brain?s white matter in old age. The MRC funding we received from 2008-2010 paid for the four researchers who analyse these vital brain imaging data. We are requesting similar support for 2011-2013, when the LBC1936 will have brain scans (and other tests) at age 76.

Technical Summary

Background: During the calendar years 2008-2011, MRC contributed cash-limited funds to the Disconnected Mind project team, for staff to analyse data from the first wave of brain magnetic resonance imaging (MRI) studies in the Lothian Birth Cohort 1936 (LBC1936). This has been done and has provided a cutting-edge examination of the brain?s white matter in over 725 people in the LBC1936. With further discussion with the relevant MRC programme manager (Rob Buckle) we have been permitted to apply for a similar complement of staff to analyse the next wave of brain imaging data in the Lothian Birth Cohort 1936, to cover the calender years 2011-2013. All other costs will be met by Age UK.

Science: In this proposal we seek to characterize longitudinal changes in brain white matter structure in old age, and to investigate relationships between brain biological ageing and cognitive ageing in a unique cohort of subjects in whom cognitive data are available in both youth and across old age, and who have just completed a first wave of detailed brain imaging. The average age of the cohort, which is ideal to study ageing affects, the narrow age range, longitudinal MRI, genetic and lifestyle information, and the availability of life-long measures of cognitive ability provide an unparalleled opportunity to study relationships between brain structural and cognitive ageing.

Organisations

Publications

10 25 50

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Aribisala BS (2014) Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects. in Cortex; a journal devoted to the study of the nervous system and behavior

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Aribisala BS (2013) Assessing the performance of atlas-based prefrontal brain parcellation in an aging cohort. in Journal of computer assisted tomography

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Booth T (2014) Personality, health, and brain integrity: the Lothian birth cohort study 1936. in Health psychology : official journal of the Division of Health Psychology, American Psychological Association

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Cole JH (2018) Brain age predicts mortality. in Molecular psychiatry

 
Title Artwork commissioned for the Edinburgh Imaging Facility RIE 
Description Prof Joanna Wardlaw commissioned artwork for the windows for a new neuroimaging suite a the Royal Infirmary of Edinburgh, called Edinburgh Imaging Facility RIE. The artwork incorporates a time line of neuroscience, neural networks, and Edinburgh. The artist, India Cawley Gelling, was an art student at the University of Edinburgh. 
Type Of Art Artwork 
Year Produced 2017 
Impact The artwork was installed in the windows of the main entrance and patient waiting area of the Edinburgh Imaging Facility RIE and is visible to all who visit the imaging suite. 
URL https://www.ed.ac.uk/clinical-sciences/edinburgh-imaging/for-patients-study-participants/finding-our...
 
Title Brain Box 
Description Brain Box is a portable workshop/festival resource to excite children and adults about the brain, how it works and the changes it goes through in a lifetime. It is a resource for guided workshops, festivals, exhibitions and events that would over time develop an online "personality" tweeting about its day with photo's, comments and quotes: see me on Twitter @brainboxone 
Type Of Art Artefact (including digital) 
Year Produced 2014 
Impact To date, the Brain Box has received funding from the MRC Regional Communications Fund and, despite still being at the development stage, is planned to appear at workshops as part of the Edinburgh International Science Festival 14-18 April 2015. 
URL http://www.twitter.com/brainboxone
 
Title Brain Training on Trial 
Description An hour-long show developed for the Edinburgh Festival Fringe 2014, involving audience participation and presentation of research on the usefulness of brain training. The show took the form of a 'trial' in which the audience was the jury and co-presenter the judge. 
Type Of Art Performance (Music, Dance, Drama, etc) 
Year Produced 2014 
Impact The trailer for the show was uploaded to You Tube and has been viewed 534 times as at 7th November 2014 (http://www.youtube.com/watch?feature=player_embedded&v=9g2puKGaE-E). The post-event summing up video has also been uploaded to You Tube on 20th October 2014 and has been viewed 70 times (http://www.youtube.com/watch?v=fROGW49Z81Q). A blog post was also written summarising the evidence for and against brain training. 
URL http://researchtheheadlines.org/2014/09/09/brain-training-on-trial/
 
Title LBC1936 Fast Facts Card 
Description Dr Simon Cox and Professor Ian Deary designed a 'Lothian Birth Cohort 1936 Fast Facts Card' - a 12 facet credit-card sized concertina leaflet containing information about the LBC1936 study for distribution to the general public at future KE events, interested academics / potential collaborators, LBC members etc. 
Type Of Art Artefact (including digital) 
Year Produced 2014 
Impact This has been distributed to interested academics and potential collaborators and will be distributed to participants in the Lothian Birth Cohort 1936. Age Scotland have requested 150 and an initial print run consisted of 2000 copies. 
 
Title Lifetimes book - Ann Lingard 
Description CCACE collaborated with a local author, Ann Lingard, to create a short book entitled 'Lifetimes - personal stories from the Lothian Birth Cohorts'. Ann interviewed several participants in both Lothian Birth Cohorts 1921 and 1936 and several members of staff, including the Centre director, creating this short collection of life stories. It has been professionally typeset with an attractive cover and introduction by CCACE/LBC director Ian Deary. It is heavily illustrated with photographs reflecting the life courses of the participants and scientists in the Lothian Birth Cohort studies. 
Type Of Art Creative Writing 
Year Produced 2014 
Impact The book has been sent to all CCACE collaborators and contacts, as well as being given out to participants at the Lothian Birth Cohort reunion in April 2014. It has been available to download as an e-book on various websites for many months. About 2000 physical copies of the book have been printed. It is free on iTunes, and there is a nominal cost (77p) on Amazon for a Kindle edition. 
URL https://itunes.apple.com/gb/book/lifetimes/id893954634?mt=11
 
Title Portraits - Fionna Carlisle 
Description CCACE has been collaborating with a local artist, Fionna Carlisle, who has painted portraits of the Centre director, Ian Deary, several of the Centre's staff, and a number of participants from the Lothian Birth Cohort studies. She is aiming to complete a collection of over 20 portraits of participants and scientists. 
Type Of Art Artwork 
Year Produced 2014 
Impact The artwork has been displayed at a number of prestigious local and national events, including as part of an exhibition at the British Library in London entitled Portraying Ageing on 28th April 2014, and at local events associated with the MRC Centenary. The CCACE knowledge exchange officer and Fionna Carlisle, along with Centre director Ian Deary, are in discussion with local art galleries and museums with regard to a full-scale exhibition of these portraits and the scientific programme of work which lies behind them. 
URL http://www.fionnacarlisle.com/
 
Title The Living Brain short film - Anne Milne 
Description CCACE collaborated with film maker Anne Milne to produce a short film describing the Lothian Birth Cohort 1921 and 1936 studies and charting the life course and current circumstances of one participant from each study. The film was premiered at the Lothian Birth Cohort reunion in April 2014 and has since been screened a number of times, including at the CCACE Annual Research Day in August 2014 and Midlothian Science Festival in October 2014. 
Type Of Art Film/Video/Animation 
Year Produced 2014 
Impact The film has been screened a number of times, both to research participants, collaborators and other academics, and members of the public attending a science festival talk. It has now been seen by, we estimate, many hundreds of people and Anne Milne has plans to submit it to film festivals and science festivals. The film is listed on www.imdb.com. 
URL http://www.imdb.com/name/nm3596775/
 
Description Age UK/AARP Global Council on Brain Health expert meeting (Gow)
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact The Global Council on Brain Health convenes experts who then produce reports on factors affecting cognitive and brain function. These are widely distributed so that people's knowledge and actions (e.g. lifestyle changes) are based upon the best available empirical evidence. This is done in part via Age UK, the largest UK ageing charity with a very wide reach to older people in the UK and internationally.
URL http://www.ageuk.org.uk/professional-resources-home/research/about-age-uk-research/the-global-counci...
 
Description Deary - AMRC Summer parliamentary Reception
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Deary - David Willetts, MP
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Deary - Resources for Democracy
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Deary - Scottish Parliament Cross Party Group on Older People Age and Ageing
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in advisory committee
 
Description Forum "Influencing the trajectories of ageing" - Ian Deary
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact The Academy of Medical Science brought together international experts on the influences on human and other animal ageing systems. These were presented in a forum conducted under Chatham House rules. There was an invited audience of about 60 experts in total. Each of the presentations-including Ian Deary's-was summarised and compiled in a report that was made available as an online PDF, communicated to the news media, and is intended to influence policy makers on the important issue of how to optimise the trajectories of human health across the full life course.
URL https://acmedsci.ac.uk/more/news/trajectories-of-ageing-balancing-longevity-and-health
 
Description Government Office for Science "Evidence and Options for Preserving Cognition Through Life" - Ian Deary
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL http://www.ccace.ed.ac.uk/node/336
 
Description ADRC - Scotland, ESRC
Amount £7,930,752 (GBP)
Funding ID ES/L007487/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 11/2013 
End 10/2018
 
Description Edinburgh Lothians Health Foundation BraINS - Shenkin Wardlaw Job
Amount £38,810 (GBP)
Organisation Edinburgh & Lothians Health Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2014 
End 03/2015
 
Description Evaluating Longitudinal Changes in the Human Structural Connectome in Relation to Cognitive Aging
Amount $502,543 (USD)
Funding ID 1R01AG054628-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2017 
End 04/2022
 
Description How do peripheral and central vascular markers relate to cognitive decline? - Deary
Amount £91,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2015 
End 01/2017
 
Description INTERpreting epigenetic signatires in Studies of Early Life Adversity (interSTELA) - Deary
Amount £199,512 (GBP)
Funding ID ES/N000382/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 09/2015 
End 08/2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)"
Amount € 49,855 (EUR)
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND) 
Sector Public
Country European Union (EU)
Start 01/2017 
End 12/2017
 
Description MRC Integrated dementia research environment
Amount £6,825,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2015 
End 03/2016
 
Description MRC UK Dementia Platform
Amount £5,639,037 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 03/2019
 
Description NIA - Human structural connectome
Amount $2,384,683 (USD)
Funding ID R01AG054628 
Organisation National Institute on Aging 
Sector Public
Country United States
Start 07/2017 
End 06/2022
 
Description Project grant - JPND (Deary)
Amount £592,325 (GBP)
Funding ID MR/N027558/1 
Organisation Medical Research Council (MRC) 
Department MRC Human Nutrition Research Unit
Sector Public
Country United Kingdom
Start 05/2016 
End 04/2019
 
Description Researcher Links, British Council - Aribisala / Gow
Amount £4,320 (GBP)
Organisation British Council 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2014 
End 10/2014
 
Description SFC SINAPSE Network development - Wardlaw et al
Amount £325,000 (GBP)
Organisation Government of Scotland 
Department Scottish Funding Council
Sector Public
Country United Kingdom
Start 10/2014 
End 09/2019
 
Description Seniors USP - LLHW
Amount £992,001 (GBP)
Organisation Medical Research Council (MRC) 
Department Lifelong Health and Wellbeing (LLHW)
Sector Public
Country United Kingdom
Start 05/2014 
End 04/2017
 
Description The Disconnected Mind: Phase 4
Amount £1,058,650 (GBP)
Organisation Age UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2019 
End 03/2022
 
Title 3D brain 
Description A 3D Brain based on MRI Scans has been developed. This Brain is true 3D in cyberspace and can be viewed and projected in anaglyph 3D and well as a higher quality rendition using a fast shuttered glasses system from Nvidia. Two Brains are available for viewing at the moment , a healthy young and a healthy old brain. The 3D brain can be rotated and zoomed in real time to allow the demonstration of anatomical features on the reconstructed models. The tools developed are capable of importing any 3D model and future developments may include tractography etc. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2013 
Provided To Others? Yes  
Impact This system was used as a demonstrator at the opening of CRIC by HRH Duke of Edinburgh. In 2011 it was demonstrated at the Edinburgh International Science Festival that attracted ~3000 visitors, at the Glasgow Science Centre, and has been taken around schools by CCACE employee Jack Nissan. In 2014 the 3D brain was demonstrated at the Edinburgh Neuroscience Day (March 12th 2014) and at a reception held by Age UK at St James's Palace and hosted by HRH Prince Charles (Jan 28th 2014). 
 
Title Brain Observer Microbleeds Scale (BOMBS) 
Description If the diagnostic and prognostic significance of brain microbleeds are to be investigated and used for these purposes in clinical practice, observer variation in BMB assessments must be minimised. This scale takes into account the main sources of inter-rater disagreement in rating microbleeds seen in brain imaging, especially in older people. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2009 
Provided To Others? Yes  
Impact This has been published in the journal Stroke and made available to international researchers. This provides a new, well-validated scale for an important aspect of often-ignored brain pathology to be assessed in the older brain. Cordonnier, C., et al (2009) . Improving interrater agreement about brain microbleeds: Development of the brain observer microbleed scale (BOMBS). Stroke, 40, 94-99. 
URL http://www.sbirc.ed.ac.uk/research/imageanalysis.html#bombs
 
Title CCACE - LBC Lifetimes website 
Description The professional writer Ann Lingard composed stories of the lives of members of the Lothian Birth Cohorts of 1921 and 1936 and some of the wscientists working on the research. Each life was "told" as a small online facsimilie book with pictures across the lifecourse of each person. The individual books are professional looking and they have been gathered on to a website. The CCACE Systems Analyst worked closely with the CCACE Knowledge Exchange Officer to develop a new website for a large CCACE arts project called LBC Lifetimes. The project was set up to create stories of the lives and lifetimes of some of the participants and scientists involved in the LBC1936 study. The site has been viewed over 2300 times. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact The stories are available internationally for those wishing to learn more about the personal backgrounds of participants and esearchers in the Lothian Birth Cohort studies. 
URL http://www.lbclifetimes.org
 
Title Cox - frontal lobe parcellation method 
Description Identified and developed a novel method for identifying frontal lobe sub-regions from gyral topography based on a synthesis of previous methods and data from cytoarchitecture and hodology. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2014 
Provided To Others? Yes  
Impact The method was published in Brain Structure and Function (Impact Factor: 7.84) and this paper has been made available with supporting documentation online in the Image Analysis Tool section of the Brain Imaging Research Centre website (http://www.bric.ed.ac.uk/research/imageanalysis.html). Other publications resulted from this method and are published Cortex and Intelligence. 
 
Title Image analysis method - hippocampal shape modelling 
Description In collaboration with the Korean Advanced Institute for Science and Technology, we have developed a novel method for hippocampal shape modelling. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Cox SR*, Valdés Hernández MC*, Kim J, Royle NA, MacPherson SE, Ferguson KJ, Muñoz Maniega S, Anglaban D, Aribisala BS, Bastin ME, Park J, Starr JM, Deary IJ, MacLullich AJM, Wardlaw JM. Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men. Psychoneuroendocrinology, doi: 10.1016/j.psyneuen.2017.01.027. Kim J, Valdés Hernández MC, Royle NA, Park J. Hippocampal shape modelling based on a progressive template surface deformation and its verification. IEEE Trans Med Imaging 2015 Jun;34(6):1242-61 Valdés Hernández MC, Cox SR, Kim J, Royle NA, Muñoz Maniega S, Gow AJ, Anglaban D, Bastin ME, Park J, Starr JM, Wardlaw JM, Deary IJ. Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936. Neurobiol Aging in press. 
URL http://ieeexplore.ieee.org/document/6990617/?reload=true
 
Title Image analysis method - new automated segmentation tool for multifocal basal ganglia hypointeisities 
Description A new tool for automated segmentation of multifocal basal ganglia T2*-weighted hypointensities 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Glatz A, Bastin ME, Kiker AJ, Deary IJ, Wardlaw JM, Valdés Hernández MC. Automated segmentation of multifocal basal ganglia T2*-weighted MRI hypointensities. Neuroimage 2015 Jan 105: 332-346. 
 
Title Image analysis methods - IXICO 
Description Wardlaw and colleagues have been involved in developing analysis method for older subjects with IXICO, a commercial imaging research group. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact A Technology Strategy Board grant has been applied for based on pilot work. 
 
Title Liewald - CCACE cluster 
Description The CCACE computer cluster has been designed to allow it to deal with large GWAS datasets held by CCACE such as 1000G, exome sequencing and also the Generation Scotland reference genome sets. In conjunction with this are new file handling and merging techniques and pipelines which had to be developed to allow researchers to access and utilise these huge data resources. 
Type Of Material Biological samples 
Provided To Others? No  
Impact We have the capability of conducting, securely, large scale genetic analyses for our team and of allowing access to collaborators internationally. 
 
Title New method of perivascular space segmentation on brain MRI 
Description MRC-funded imaging team on the LBC1936 developed a new method of perivascular space segmentation, which shows good concordance with neuroradiological assessments. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2016 
Provided To Others? Yes  
Impact Ballerini L, Lovreglio R, Valdés Hernández MC, Gonzalez-Castro V, Muñoz Maniega S, Pellegrini E, Bastin ME, Deary IJ, Wardlaw JM. Application of the ordered logit model to optimising Frangi filter parameters for segmentation of perivascular spaces. Procedia Comp Sci 2016 90:61-67. 
URL http://www.sciencedirect.com/science/article/pii/S1877050916311899
 
Title Wardlaw - Imaging-related research tools 
Description Wardlaw's group continues to develop a large number of imaging-related research tools for visual assessment of images and computational quantitative measurements. These include methods for measuring white matter hyperintensities, brain mineral deposition, perivascular space enlargement, and brain shrinkage. Links to these tools are available through the Brain Research Imaging Centre website (www.sbirc.ed.ac.uk/research/imageanalysis.html). 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact Members of the neuroimaging group have been invited to speak about their materials in London, Austria, North America, and at majpr conferences such as the European Society of Magnetic Resonance in Medicine. 
URL http://www.sbirc.ed.ac.uk/research/imageanalysis.html
 
Title Brain Images of Normal Subjects (BRAINS) Imagebank 
Description The Brain Images of Normal Subjects (BRAINS) imagebank is an integrated repository project sponsored by the University of Edinburgh and the Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE) collaborators. The purpose of BRAINS is to provide sharing and archiving of detailed normal human brain imaging and relevant phenotypic data, to create better estimates of the range of normal brain size and integrity across the life-course. The Lothian Birth Cohort 1921 and 1936 brain imaging data along with limited clinical data has been added to this resource. BRAINS is a living imagebank where new data will be added when available. Initially BRAINS will contain existing data from n=763 healthy volunteer subjects, range neonatal and 19-81 years of age, from projects in 3 centres. A further n=2119 subjects aged from prenatal to 90 years old with existing records from 15 other projects in Scotland are currently being collected, collated and quality control (QC) checked. Additional completed and ongoing studies of normal individuals will be uploaded as they become available. The data include several magnetic resonance imaging (MRI) sequences, including T1, T2, T2*, fluid attenuated inversion recovery (FLAIR), and Diffusion Tensor Imaging (DTI), in DICOM and NIfTI format, and a wide range of linked metadata, such as age, history, physiological measures (e.g. blood pressure), cognitive ability, and perinatal information (neonatal data). Data access is governed by a steering committee comprising the PIs of the contributing studies, experts in ethics, law and governance, and lay representatives. Applications for data access can be made online, and will be granted by the steering committee subject to the completion of a formal Data Access Agreement. http://www.brainsimagebank.ac.uk/ 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact The initial publication which describes the resource was: "A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)" Dominic E Job, David A Dickie, David Rodriguez, Andrew Robson, Cyril Pernet, Mark Bastin, James P Boardman, Alison D Murray, Trevor Ahearn, Gordon D Waiter, Roger T Staff, Ian J Deary, Susan D Shenkin, Joanna M Wardlaw. NeuroImage. doi: 10.1016/j.neuroimage.2016.01.027 PMID: 26794641. We have developed seven age-specific atlases of T1 brain MRI from 25 to 92 years, which have been made available on the BRAINS website. Dickie, David Alexander; Job, Dominic E.; Rodriguez, David; Robson, Andrew; Danso, Samuel; Pernet, Cyril; Bastin, Mark E.; Deary, Ian J.; Shenkin, Susan D.; Wardlaw, Joanna M.. (2016). Brain Imaging of Normal Subjects (BRAINS) age-specific MRI atlases from young adults to the very elderly (v1.0), [dataset]. University of Edinburgh, Edinburgh Imaging, CCBS, BRAINS Imagebank. http://dx.doi.org/10.7488/ds/1369. 
URL http://www.brainsimagebank.ac.uk
 
Description "Computational approach towards the characterisation of global and subregional brain changes with ageing and on the presence of cerebrovascular and neurodegenerative diseases" 
Organisation Korea Advanced Institute of Science and Technology (KAIST)
Department Computer Science Department
Country Korea, Republic of 
Sector Academic/University 
PI Contribution BRIC and Computer Graphics and Visualisation Research Lab, Computer Science Department We provided the reference segmentations (i.e. binary masks) of all the brain structures to be analysed within the context of this project, and on a visit done to KAIST on March we tested the hippocampal model previously developed by KAIST on a wider representative sample and together with KAIST collaborators we improved it incorporating alternative deformation procedures, and developed and tested a pipeline to determine the anatomical deformation to analyse shape variation on subgroups of the sample provided through the calculation of regional variations. The results showed that there are specific areas in the hippocampi for which the deformation is the opposite within each subgroup pair, strongly suggesting that these areas are related to the cognitive/biological parameter evaluated (i.e. general cognition, information processing speed, hypertension, etc). The analysis of the deformation in relation to gender revealed negligible differences between males and females, suggesting that the patterns seen in the analysis of the rest of the biological and cognitive parameters were independent and not determined/influenced by gender differences. We are currently drafting two manuscripts with these results. During the visit, we also agreed on a follow-up plan that includes the generation of the mesh models for other brain structures and evaluated alternatives to pursue them.
Collaborator Contribution Korea Advanced Institute of Science and Technology (KAIST
Impact Up to date, we have obtained 2 grants: one small grant for visiting KAIST (£2,240) and the grant that funds this collaboration for 2 years (£35,143.93) and are writing 2 publications.
Start Year 2011
 
Description Andrew McIntosh 
Organisation University of Edinburgh
Department Division of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution We provided brain imaging data and personality and mood variables.
Collaborator Contribution This has allowed the examination of brain imaging associations with additional phenotypes, in this case personality and mood states of anxiety and depression.
Impact A paper has been submitted to a journal.
Start Year 2010
 
Description Cox - Interconnectivity of Cerebral Sites - Colab. Pilot 
Organisation Lagos State University
Department Department of Computer Science
Country Nigeria 
Sector Academic/University 
PI Contribution Provided the concept and neuranatomical basis for development of a study specific method for identifying and measuring white matter connectivity between cerebral regions in older participants.
Collaborator Contribution The proposed study represents an international collaborative effort that marries expertise in neuropsychology, neuroanatomy, computer science and ageing research.
Impact A method for exploiting manual frontal lobe parcellations to measure specific site-to-site white matter connectivity in the brains of older persons. In addition to the method development, several manuscripts are planned which will examine the cognitive correlates of individual differences in intra-frontal and fronto-hippocampal connections. Preliminary results presented at two conferences (OHBM 2014 by Aribisala, and ISMRMB 2014 by Cox). Manuscript in preparation, collaboration with Psychiatry at UoE (Prof Lawrie) using this method in preliminary stages. Additional development work planned for use in the Lothian Birth cohorts.
Start Year 2013
 
Description EU Joint programme - Neurodegenerative Disease Research 
Organisation Lille University Hospital
Country France 
Sector Hospitals 
PI Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Collaborator Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Impact This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Start Year 2013
 
Description EU Joint programme - Neurodegenerative Disease Research 
Organisation Medical University of Graz
Country Austria 
Sector Academic/University 
PI Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Collaborator Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Impact This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Start Year 2013
 
Description EU Joint programme - Neurodegenerative Disease Research 
Organisation Paris Diderot University
Country France 
Sector Academic/University 
PI Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Collaborator Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Impact This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Start Year 2013
 
Description EU Joint programme - Neurodegenerative Disease Research 
Organisation Technical University of Munich
Country Germany 
Sector Academic/University 
PI Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Collaborator Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Impact This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Start Year 2013
 
Description Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) consortium 
Organisation National Center for Biotechnology Information (NCBI)
Country United States 
Sector Public 
PI Contribution The ENIGMA consortium aims to perform meta-analysis of brain imaging and genetics in ageing using data from the LBC1921 and LBC1936 studies with other international collaborators.
Collaborator Contribution Data from international collaborators has been brought together to perfom meta-analysis.
Impact Data from the LBC1921 and LBC1936 has been transferred for meta-analysis. Papers on brain imaging, genetics and ageing are currently being prepared. One paper is in revision with Nature Genetics titled "Common genetic polymorphisms contribute to the variation in human hippocampal and intracranial volume". Potentially this collaboration with ENIGMA will extend to include analysis of subcortical brain structures. Also, Deary has made a proposal to take a lead on the GWAS analysis of brain white matter integrity.
Start Year 2010
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Aarhus University
Country Denmark 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Alberta Health Services
Country Canada 
Sector Public 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Boston University
Country United States 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Chinese University of Hong Kong
Country Hong Kong 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Erasmus University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Lariboisière Hospital
Country France 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Leiden University Medical Center
Country Netherlands 
Sector Multiple 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Ludwig Maximilian University of Munich (LMU Munich)
Country Germany 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Maastricht University Medical Center+
Country Netherlands 
Sector Hospitals 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Massachusetts General Hospital
Country United States 
Sector Hospitals 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation McMaster University
Country Canada 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Medical University of Graz
Country Austria 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation National Institutes of Health (NIH)
Country United States 
Sector Public 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation National University of Singapore
Country Singapore 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Radboud University Nijmegen Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation The Otto-von-Guericke University Magdeburg
Country Germany 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University Hospital Carl Gustav Carus Dresden
Country Germany 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University Medical Center Rotterdam
Country Netherlands 
Sector Hospitals 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University Medical Center Utrecht (UMC)
Country Netherlands 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Bonn
Country Germany 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Bordeaux
Country France 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Calgary
Country Canada 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of California, Davis
Country United States 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Florence
Country Italy 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Iceland
Country Iceland 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Laval
Country Canada 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of New South Wales
Country Australia 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Western University
Country Canada 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description Network of Centres of Excellence in Neurodegeneration (COEN) 
Organisation German Centre for Neurodegenerative Diseases
Country Germany 
Sector Public 
PI Contribution MRC Centres of Excellence in Neurodegeneration. Worldwide collaborators in Germany, Italy, France, Canada, USA, Australia and the UK. Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver.
Collaborator Contribution International experts in neuro-imaging of ageing, small vessel disease, neurodegeneration and methodology of multimodel MRI across sites.Multiple skill sets of collaborators including small vessel disease; dementia, stroke and brain atrophy; MR physics sequence development for neuroimaging. Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver.
Impact COEN grant consortium established standards to SVD across two workshops in 2012. Main paper published 2013. A research fellow from Maastricht (COEN participant van Oostenbrugge) visited Edinburgh and performed further development of individual SVD features into a total sum score. One paper published (see publications) and one paper in review, publication pending.
Start Year 2010
 
Description Network of Centres of Excellence in Neurodegeneration (COEN) 
Organisation University of Calgary
Department Department of Clinical Neurosciences
Country Canada 
Sector Academic/University 
PI Contribution MRC Centres of Excellence in Neurodegeneration. Worldwide collaborators in Germany, Italy, France, Canada, USA, Australia and the UK. Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver.
Collaborator Contribution International experts in neuro-imaging of ageing, small vessel disease, neurodegeneration and methodology of multimodel MRI across sites.Multiple skill sets of collaborators including small vessel disease; dementia, stroke and brain atrophy; MR physics sequence development for neuroimaging. Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver.
Impact COEN grant consortium established standards to SVD across two workshops in 2012. Main paper published 2013. A research fellow from Maastricht (COEN participant van Oostenbrugge) visited Edinburgh and performed further development of individual SVD features into a total sum score. One paper published (see publications) and one paper in review, publication pending.
Start Year 2010
 
Description Normative Brain Image Bank - Ian Deary/ Joanna Wardlaw 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Normative Brain Image Bank: with Aberdeen, Glasgow, Dundee in creation of a normative brain image bank across the life course but specifically for older ages; including external collaboration with UCSF, California (Toga), Montreal Neurological Institute (Evans), Paris (Poline) -JM Wardlaw, M Bastin, I Deary).
Collaborator Contribution The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.
Impact The project is ongoing with the plan that it will create a bank of brain images. Grant application submitted.
Start Year 2010
 
Description Normative Brain Image Bank - Ian Deary/ Joanna Wardlaw 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution Normative Brain Image Bank: with Aberdeen, Glasgow, Dundee in creation of a normative brain image bank across the life course but specifically for older ages; including external collaboration with UCSF, California (Toga), Montreal Neurological Institute (Evans), Paris (Poline) -JM Wardlaw, M Bastin, I Deary).
Collaborator Contribution The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.
Impact The project is ongoing with the plan that it will create a bank of brain images. Grant application submitted.
Start Year 2010
 
Description Normative Brain Image Bank - Ian Deary/ Joanna Wardlaw 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Normative Brain Image Bank: with Aberdeen, Glasgow, Dundee in creation of a normative brain image bank across the life course but specifically for older ages; including external collaboration with UCSF, California (Toga), Montreal Neurological Institute (Evans), Paris (Poline) -JM Wardlaw, M Bastin, I Deary).
Collaborator Contribution The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.
Impact The project is ongoing with the plan that it will create a bank of brain images. Grant application submitted.
Start Year 2010
 
Description SPIRIT/SINAPSE - Joanna Wardlaw 
Organisation Bayer
Department Bayer HealthCare
Country Germany 
Sector Private 
PI Contribution GE Healthcare in collaborated project SPIRIT through SINAPSE. "Improved diagnostics for Magnetic Resonance imaging in microvascular stroke and ageing: quantification of brain mineralisation using MR imaging" started in 2010 (ME Bastin, MC Valdés Hernández and JM Wardlaw)
Collaborator Contribution The group provided expertise.
Impact Publication of papers is ongoing.
Start Year 2010
 
Description Sfc Brain Research Imaging Centre (SBIRC) 
Organisation University of Edinburgh
Department Brain Research Imaging Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution The SBIRC is the organisation which is responsible for housing the expertise and data management related to brain imaging of the LBC 1936. The CCACE database manager, Mr Dave Liewald, has formed a working partnership with the SBIRC team to write software for a new database for collecting brain imaging clinical data.
Impact This is a key collaborative group with which the Centre works and many joint publications related to brain imaging aspects of cognitive ageing have appeared, as listed below. Dave Liewald developed a software prototype for this group which has now been fully tested. 17624630 18931002 19095989 19451533 17869382 18690455 19344368 17719145 18340104 19536582 19346327 18931005 19131659 19850898 18617668 19064881 19213950 19341481 19211227 18309161 19260033
Start Year 2009
 
Description Shenkin - BraINS (Brain Imaging in Normal Subjects) 
Organisation University of Edinburgh
Department Brain Research Imaging Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution collaboration with multidisciplinary staff in Scottish Brain Imaging Centre (SBIRC) (neuroradiologists, image data managers, information technologists) to develop a searchable bank of normal brain images collected from previous research studies (several conducted by members of CCACE in geriatric medicine, psychology and psychiatry). No funding at present (application to CSO rejected, but encouraged international collaboration to set up resource).
Collaborator Contribution As above.
Impact No outputs yet. Aim is to develop a searchable database, and ultimately expand to an international, on-line, searchable resource.
Start Year 2011
 
Description Sherif Karama - McGill University, Montreal 
Organisation McGill University
Department Montreal Neurological Institute and Hospital
Country Canada 
Sector Hospitals 
PI Contribution We provided brain imaging data and cognitive phenotypes.
Collaborator Contribution They analysed our brain imaging data for brain cortical thickness and conducted statistical analyses.
Impact Published papers and papers in progress. Pub med IDs: 23732878, 21241809
Start Year 2008
 
Description Toshiba Medical Visualisation Systems 
Organisation Toshiba Medical Visualisation Systems
Country United Kingdom 
Sector Private 
PI Contribution - Supervising student project on a comparison of 4 unsupervised clustering algorithms for segmenting brain tissue in multi-spectral MR data. - Discussions are ongoing with Toshiba Medical Visualisation Systems regarding development of normative brain atlases and potential development of image processing tools.
Collaborator Contribution - Plans to develop normative brain atlases and potentially image processing tools. - ED student of the Institute for System Level Integration collaboratinmg for 2x8 weeks
Impact Talk at BIOSTEC 2010 (Third International Joint Conference on Biomedical Engineering Systems and Technologies).
Start Year 2008
 
Description Toshiba Medical Visualisation Systems - Joanna Wardlaw 
Organisation Toshiba Medical Visualisation Systems
Country United Kingdom 
Sector Private 
PI Contribution Toshiba Medical Visualisation Systems (TMVS) in collaborated projects through SINAPSE. "Neuroimage processing tools for studies of brain ageing" started in 2008 (MC Valdés Hernández and JM Wardlaw)
Collaborator Contribution They brought expertise to the group.
Impact Projects are currently ongoing.
Start Year 2008
 
Title LACunar Intervention (LACI-1) Trial-1: Preventing cognitive decline and dementia from cerebral small vessel disease 
Description A quarter of all ischaemic strokes are lacunar (small vessel) in type, about 35000 per annum in the United Kingdom, and due to an intrinsic, non-atheromatous, non-cardioembolic perforating cerebral arteriolar disease. 'Small vessel disease' also affects the brain diffusely, causing up to 40% of dementias, alone or mixed with Alzheimer's disease, 350,000+ patients estimated currently in the United Kingdom. There is no proven treatment: conventional antiplatelet drugs may be ineffective or even hazardous, antihypertensive treatment and statins have been disappointing. The disease mechanism is poorly understood but endothelial dysfunction, blood-brain barrier failure and vessel stiffness appear to contribute to the pathogenesis. Promising data available for licensed drugs with relevant modes of action, cilostazol (>6000 stroke patients in the Asia Pacific region) and isosorbide mononitrate (ISMN, widely used in cardiac disease) support their testing in small vessel disease. LACI-1 was a phase 2, randomised, dose-escalation, factorial trial to test short-term administration of cilostazol, Isosorbide Mononitrate, both, or neither, to provide data on patient tolerability of dose (including headache, dizziness), safety (including blood pressure, platelet function), provide mechanistic evidence of efficacy (cerebrovascular reactivity, arterial compliance), and to inform the design of a larger phase 2-3 trial. The trial recruited 57 patients with small vessel disease, in two expert stroke centres (Edinburgh and Nottingham) where there are suitable patients, expert stroke centres, established trials infrastructures and neuroimaging and platelet testing expertise. The trial will also advance methods to stratify patients by small vessel disease burden in routine practise and data on intermediary mechanistic outcomes to assist in planning future trials testing novel agents for either stroke or dementia. 
Type Therapeutic Intervention - Drug
Year Development Stage Completed 2015
Development Status Under active development/distribution
Clinical Trial? Yes
UKCRN/ISCTN Identifier EudraCT number: 2015-001953-33
Impact LACI-2 will be a follow-up to the the LACI-1 trial. LACI-2 will test whether a much larger scale study testing the effects of Cilostazol and ISMN on preventing brain damage from small vessel disease will be feasible. We will assess how easy is it to identify suitable patients, how many of them are willing to take part in the study and how many stay on the study for the full 12 months. Feedback from participants on study procedures/burden will also inform any future studies. We will also collect information on how many patients have another stroke, experience difficulties in independent daily living or in thinking skills, and on drug safety such as bleeding. 
URL http://www.isrctn.com/ISRCTN12580546
 
Title LACunar Intervention (LACI-2) Trial-2: Assessment of safety and efficacy of cilostazol and isosorbide mononitrate to prevent recurrent lacunar stroke and progression of cerebral small vessel disease 
Description The LACI-2 study is a follow-up from the LACI-1 trial. LACI-2's trial hypothesis is to test whether a much larger scale study testing the effects of Cilostazol and isosorbide mononitrate on preventing brain damage from small vessel disease will be feasible. We will assess how easy is it to identify suitable patients, how many of them are willing to take part in the study and how many stay on the study for the full 12 months. Feedback from participants on study procedures/burden will also inform any future studies. We will also collect information on how many patients have another stroke, experience difficulties in independent daily living or in thinking skills, and on drug safety such as bleeding. 
Type Therapeutic Intervention - Drug
Year Development Stage Completed 2018
Development Status Under active development/distribution
Clinical Trial? Yes
UKCRN/ISCTN Identifier EudraCT number: 2016-002277-35
Impact The LACI-2 study started recruitment in January 2018. On completion of the study a clinical study report will be prepared for publication in a peer reviewed journal in accordance with ICH guidelines. 
URL http://www.isrctn.com/ISRCTN14911850
 
Title MCMxxxVI Imaging Software - Maria Valdes Hernandez 
Description Maria Valdes Hernandez (CCACE member) has developed a new imaging software package. MCMxxxVI (1936) is a new versatile automatic technique for measuring volume biomarkers in the ageing brain. 
Type Support Tool - For Fundamental Research
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact The software is open source and available for downloading from www.sbirc.ed.ac.uk under the Apache License version 2.0, Jan 2004. 
URL http://www.sbirc.ed.ac.uk
 
Title Iron Deposits Segmentation Guidlines 
Description Detailed guidelines (manual) to use the software package Analyze 9.0 to identify and quantify brain microbleeds and hemosiderin deposits in T2*-weighted MR sequences. Uploaded to the internet in December 2009. 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2009 
Impact Novel MRI analysis tool, suitable for large samples. 
 
Title Software MCMxxxVI 
Description This software implements the Multispectral Colouring Modulation and Variance Identification method developed in the SFC Brain Image Research Centre for doing the Tissue Segmentation and Volume Analysis in MR images and incorporates some post-processing tools important for displaying and calculating the statistics of the features segmented. Four modules were uploaded to the internet in December 2009 (as open source software). 
Type Of Technology Software 
Year Produced 2009 
Open Source License? Yes  
Impact Novel MRI analysis technique, suitable for large samples. 
 
Description "Financial Abuse of Older People" - Stuart Ritchie 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact February 18 2016: took part in a seminar on Financial Abuse of Older People at Age UK, alongside members of the police, policymakers, and charity workers.
Year(s) Of Engagement Activity 2016
 
Description 'AgeWell' annual event - Stuart Ritchie 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact September 1 2016: gave a talk on the LBC1936 to the 'AgeWell' annual event (general public audience) at the University of Birmingham.
Year(s) Of Engagement Activity 2016
 
Description Adam Smith Institute's 'Forum' event - Stuart Ritchie 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact December 3 2016: gave a talk on intelligence generally, including LBC1936 data, for the Adam Smith Institute's 'Forum' event (audience: general public).
Year(s) Of Engagement Activity 2016
 
Description Age UK Bake Sale 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact CCACE core staff and members help a bake sale in aid of Age UK in February 2016. The charity event was held in the Department of Psychology and was open to anyone who wanted to buy. Prizes were awarded for the cake that best linked to an area of research or study, and the most amusing design.
Year(s) Of Engagement Activity 2017
 
Description Age UK staff on LBC1936 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Age UK is one of the main founders of Professor Deary's Lothian Birth Cohorts projects on healthy cognitive ageing. This talk was one of a number given by Professor Deary and team members to a large number of workers at Age UK in order to bring them up to date with the aims, findings, and practical applications of the teams research on cognitive ageing. It is used by Age UK in order to produce information, including books and website information, on the risks and protective factors for normal cognitive ageing which is highly important for their members.
Year(s) Of Engagement Activity 2015
 
Description Ageing brain, ageing mind. Senior men's group - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Presentation about cognitive and brain ageing for a senior men's group, followed by questions and discussion.
Year(s) Of Engagement Activity 2018
 
Description BBC1 television series "Holding back the years" 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Bill Turnbull, star of BBC's Breakfast News TV, Strictly Come Dancing, Classic FM etc., came to the Psychology department on 23rd January 2017 with a BBC film crew to find out about the Lothian Birth Cohort 1936 (LBC1936)/Disconnected Mind study.

BBC1 are planning a series in the Spring called 'Holding back the years'. Each programme will feature a celebrity revisiting a place that means a lot to them, and the programmes will have a focus on the processes of human ageing. Mr Turnbull was at the University of Edinburgh in the 1970's (he shared a flat with Gordon Brown for a term!), and so his programme is based here. It was natural that, to find out more about ageing, and with an Edinburgh locus, he and the BBC filming team visited the LBC1936. A busy afternoon's filming was filled with his interviewing LBC1936 Director Ian Deary, speaking with about a dozen of the LBC1936 participants, and seeing and taking part in some cognitive testing. Look out for the series, especially the Edinburgh-based Bill Turnbull programme in a few months' time.
Year(s) Of Engagement Activity 2017
URL http://www.ccace.ed.ac.uk/node/340
 
Description BMJ picture of the week 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The 'Picture of the Week' in the BMJ (Vol 348, issue 7964) showed two brain tractography images from the Brain Research Imaging Centre and from the Clinical Research Imaging Centre, both part of Edinburgh Neuroscience at the University of Edinburgh. The larger picture is from the LBC cohort (Lothian Birth Cohort) courtesy of Dr. Mark Bastin.

The image has now been seen by a wide variety of people including public and collaborators/peers. It raises awareness of our brain and cognitive work among healthy older people, and helps people understand the advances which imaging science have made in illustrating age-related brain changes.
Year(s) Of Engagement Activity 2014
 
Description BRAINS workshop August 2014 - Wardlaw 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The workshop in August 2014 aimed to introduce the "Brain images of normal subjects" bank, which is being developed by imaging centres across Scotland. the aim is to collect data from across the lifecourse in order to create BRAINS atlases and support image analysis research and clinical reporting of brain images.

Widened interest in the BRAINS bank and informed peers and public about its existence and usefulness.
Year(s) Of Engagement Activity 2014
 
Description Brain Box 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The CCACE Director and Knowledge Exchange Officer have been involved in the development of a 'Brain Box'. This is a portable workshop/festival resource to excite children and adults about the brain, how it works and the changes it goes through in a lifetime. It is a resource for guided workshops, festivals, exhibitions and events that would over time develop an online 'personality' tweeting about its day with photos, comments and quotes: see it on Twitter @brainboxone.

This project is still in the development phase and received £4956 from the MRC Regional Communications Fund. Workshops are being planned as part of the Edinburgh International Science Festival 14-18 April 2015.
Year(s) Of Engagement Activity 2014
 
Description British Academy debate 29th April 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Centre director, Ian Deary, presented the work of the Centre as part of a debate entitled The best years of our lives? on 29th April 2014. This was very well attended - around 300 people - and well publicised by the British Academy and beyond. The debate was chaired by well-known broadcaster Sally Magnusson (who recently wrote a book on dementia which had extended interviews with Ian Deary and John Starr), and also had contributions from Age UK's Professor James Goodwin, Alzheimers Scotland's Henry Simmons, and Professor Catharine Ward-Thompson.

The event was well publicised and recordings of the debate made available through social media and the British Academy website. There was a lively discussion after the debate.
Year(s) Of Engagement Activity 2014
 
Description CCACE - Artist collaboration article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The Psycholigts is sent to all membes of the British Psychologyical Society, so will be seen by a number that tsretches in to 6 figures.

Because of wide circulation, this will be seen by tens of thousands or over 100,000 people who will see the collaboration between the Centre's science and the portrait artist.
Year(s) Of Engagement Activity 2013
 
Description CCACE - Ednburgh International Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact 3000 people visited a CCACE stand on how we measure the brain at the Edinburgh International Science Festival.

Enthusiastic response to materials, many questions, and obvious intense interest in the Centre on cognitive ageing and cognitive epidemiology.
Year(s) Of Engagement Activity 2013
 
Description CCACE - Get Up and Go publication 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Get Up and Go 2012 - Article titled "Staying Sharp" in the magazine for the over 50s, published by the City of Edinburgh Council.

This is distributed to thousands of older people in the City of Edinburgh and surrounding area.
Year(s) Of Engagement Activity 2012
 
Description CCACE - Kickstart Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Schools
Results and Impact 20 pupils attended a workshop which introduced them to science and university life.

Greater awareness of possibility of going to University and studying ageing-related material among school pupils, especially from more deprived areas.
Year(s) Of Engagement Activity 2013
 
Description CCACE - London Science Museum 3D brain 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 400 individuals visitied a stand and attended a talk on the CCACE 3D brain and associated brain imaging research. The event sparked much interest and questions across the day.
Year(s) Of Engagement Activity 2013
 
Description CCACE - MRC Centenary open day and debate 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Over 550 members of the public attended the CCACE open day and debate, which sparked questions and discussion afterwards.

Huge amount of discussion about and enthusiasm for research in to cognitive and other aspects of ageing across the whole human lifecourse. The public appreciated the highly professional nature of the brain maze. The public appreciated the highly professional debate, with nationally-known figures (Sally Magnusson, Tam Dalyell) taking part. In the reception after the debate we hosted about 200 people and launched our LBC Lifetimes, which is a web site which contains "mini-books" telling the lifestories of some of the Lothian Birth Cohort members and some of the scientists. The aim of this is to explain further the research in the Centre and to bring in a wider public.
Year(s) Of Engagement Activity 2013
URL http://youtu.be/_5naEFwmqYs?a
 
Description CCACE - Still Life Dreaming 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Still Life Dreaming - a play about the Lothian Birth Cohort 1936 at the Edinburgh Festival Fringe reported by the BBC Arts correspondent Will Gompertz "The play reveals some of the results and explores the subject of cognitive aging. Which is interesting. But the human stories are better. The tales that emerged from the individuals who had taken the test back in 1947 are now re-told" . Over 700 people attended the play in its 5 day run.

http://bbc.in/r17M3f Also reported in the BBC Review Show and The Times.
Year(s) Of Engagement Activity 2011
URL http://bbc.in/r17M3f
 
Description CCACE - Training courses 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact In 2012, 2013 and 2014 CCACE ran a number of short taining courses. These included "introduction to R programming", "longitudinal modelling", and "systematic reviews and meta-analysis".

R programming course has run 7 times between 2012-2014 with over 200 attendees.

SR course - 2 sessions. Dec 2012 (n = 16), November 2013 (n = 18).

Longitudinal modelling - 1 session in November 2013 (n = 50).

We have increased the visibility of CCACE and the skills that we can offer to a wider academic audience.
Year(s) Of Engagement Activity 2012,2013,2014
URL http://www.ccace.ed.ac.uk/students-training/training
 
Description CCACE celebrates Scottish research cohorts 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Event held at Edinburgh's General Assembly Hall, June 2018. Hundreds of participants and researchers from Scottish cohort studies came together to celebrate their contribution to, and crucial role in, healthcare research. The day's programme covered research across the entire human lifespan, beginning with a presentation by Professor James Boardman on effects of premature birth, and ending with a talk from Professor David Batty on regional disparities in mortality. The event also offered a unique opportunity to survey the opinion of current Scottish cohort participants on future uses and sharing of their data.
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=GJBbqOq4qa8
 
Description Cambo Winter Talks Series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Professor Deary gave a talk on normal cognitive ageing followed by lively discussion at this small science festival. It was a accompanied by activities related to cognitive ageing that were conducted by him and other members of the CCACE Centre.
Year(s) Of Engagement Activity 2015
 
Description Cognition and a Mediterranean diet research paper - Luciano 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact There was considerable media interest in a paper examining the link between consuming a Mediterranean diet and brain shrinkage. CCACE member, Michelle Luciano, gave Live TV interview on BBC Breakfast, pre-recorded TV interview for a South Korean News Channel, 2 Live radio Broadcasts (BBC Reporting Scotland, BBC 3 Counties), and 1 pre-recorded radio broadcast (Radio Forth)

Various interviews were also given for print media:
5/01/17: (BBC online ) (i) (The Press and Journal) (The Belfast Telegraph) (The Daily Express) (The Sun) (Metro) (New Scientist online) (The Herald) (The LA Times online (USA)) (The Times) (The Independent) (The Daily Mail) (Huffington Post online) (NBC News online) (The Irish Examiner online (Ireland)) (The Edinburgh Evening News) (The Evening Express) (La Vanguardia (Spain)) (Indo-Asian New Service (India)) (U.S. Food Stafety (USA)) (herenciageneticayenfermedad blog (Argentina)) (Health News Review (USA)) (ForeignAffairs.co.nz (New Zealand)) (Yahoo! India) (Channel 3000 (USA)) (Proceso Digital (Honduras)) (Nutraceutical World (USA)) (Top Sante (France)) (Yahoo! Actualites (France)) (The Business Standard (India)) (MedIndia (India)) (Visao Online (Portugal)) (Slashdot (USA)) (WOAI (USA)) (The New York Times (USA)) (Radio-Canada (Canada)) (Carriere Adriatico (Italy)) (Expatica (Netherlands)) (Inc.com (USA)) (WWLP (USA)) (TVA Nouvelles (Canada)) (ladepeche.fr (France)) (China News Service (China)) (The New York Times online (USA)) (Adnkronos (Italy)) (CNN (USA)) (NBC News (USA)) (U.S. News & World Report (USA)) (EFE - International Service (Spain)) (The Irish Daily Mail (Ireland)) (MedIndia (India)) (Point (France)) (AGF (Netherlands)) (Gosalute (Italy)) (Panorama (Italy)) (The New Zealand Herald) (Health Daily Digest (India)) (International Business Times (USA)) (Newser (USA)) (El Semanario Limitless (Mexico)) (Tech Times (USA)) (Day (Argentina)) (NutraIngredients.com (France)) (Sunday World (Ireland)) (La Sicillia (Italy)) (Monthly Prescribing References (USA)) (ProHealth.com (USA)) (Courrier Picard (France)) (Digital Journal (USA)) (EMaxHealth (USA)) (Sarasota Herald-Tribune (USA))
Year(s) Of Engagement Activity 2016
 
Description Cox - Age UK - New Dynamics of Ageing 2013 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Age UK A New Dynamic of Ageing. Research from the Lothian Birth Cohort 1936 showcased at this lay-conference was amongst the 35 ageing research projects who shared their latest findings, evidence and insights on age-related issues through an interactive exhibition area, presentations and themed parallel sessions. I was one of 3 CCACE members to man the stall. The meeting was attended by c.500 delegates.

Exposure.
Year(s) Of Engagement Activity 2013
 
Description Cox - Cafe Scientifique, Cockermouth 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Dr. Simon Cox gave a talk to the Café Scientifique in Cockermouth entitled: 'Postcards from your brain; we wish we were there. On the (mis)uses of brain imaging'. Illustrations of brain imaging were distributed to attendees in postcard form, and examples from the Disconnected Mind study among others were discussed as instances of appropriate MRI data usage. Now developed, Simon will also give this talk at future knowledge exchange events.

The talk was very successful with a great deal of interest and enthusiasm shown by attendees. Dr Cox hopes that this will lead to further invitations to similar events.
Year(s) Of Engagement Activity 2014
 
Description Cox - Colinton Literary Society, Feb 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Simon Cox presented a talk entitled New Adventures in Cognitive Ageing Research: The Lothian Birth Cohorts of 1921 & 1936 at The Colinton Literary Society, Edinburgh, UK. February. (c.50 attendees).

The event was successful in disseminating information on the work of the Centre and Lothian Birth Cohort studies to members of the public.
Year(s) Of Engagement Activity 2014
 
Description Cox - MRC Centenary Event - Brain Maze 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact MRC Centenary Event - Brain Maze activity demonstration. Contributed to demonstration design, set up and a small piece in the introductory film. This was part of a series of nationwide events designed to celebrate the MRC Centenary. The primary audience was the general public .

Exposure
Year(s) Of Engagement Activity 2013
 
Description Deary - 'Glasgow Skeptics' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact 10 Quite Interesting Things About IQ". Public Talk to 'Glasgow Skeptics' Prof Ian Deary. 20 Feb 2012. This was attended by about 100 people. The audience was very interested and inteactive in discussing findings about human intelligence and how it ages.

1,900 views of YouTube video
http://youtu.be/MGnCYdr7dYE
Year(s) Of Engagement Activity 2012
URL http://youtu.be/MGnCYdr7dYE
 
Description Deary - AGE UK interview on Disconnected Mind / LBC1936 April 2014 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact This interview was a wide ranging description of the rationale for and achievements of the Disconnected Mind / Lothian Birth Cohort 1936 project for internal Age UK purposes. The aim was to inform a wide range of individuals within Age UK about the achievements of this cognitive ageing (and broader ageing) study in order that professionals within the Age UK charity organisation could be well informed when dealing with policy professionals external to the organisation and older people more generally.

Age UK is the largest older age-related charity in the UK. They provide evidence to the UK government and more broadly, for example to the G7 conference. One example of the reach of the Disconnected Mind project is that the Age UK CEO, Tom Wright, delivered a talk to the G7 conference in November 2014 in Tokyo, and used evidence from the Disconnected Mind project in his slides. Also, Age UK were influential in urging the current Conservative government to undertake a large dementia initiative which was announced at the G7/G8 conference and could be partly credited for the MRC's dementias platform UK initiative.
Year(s) Of Engagement Activity 2014
URL http://www.ageuk.org.uk/about-us/what-we-do/the-disconnected-mind/
 
Description Deary - AQMeN social mobility 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This was the opening/public lecture for a course on structural equation modelling aimed at people interested in social mobility.

Both the statistical methods and the practical findings with respect to social mobility were conveyed to a range of individuals from post-graduate students to senior researchers to members of the public.
Year(s) Of Engagement Activity 2012
 
Description Deary - Age and Brain keynote, Nottingham 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact About 50 people attended this inaugural meeting of ageing reseachers at Nottingham. This was the keynote talk and there was a good question session afterwards.

The broad range of ageing reseachers led to many 2-way suggestions for further biomarkers that could be studied with respect to cognitive ageing.
Year(s) Of Engagement Activity 2012
 
Description Deary - All-party Parliamentary Group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact The lLothian Birth Cohort 1936 study was presented as a poster at this high-profile gathering of Parliamentarians and research charities.

Many interested members of the House of Lords and some MPs came to discuss the findings on cognitive ageing, and were very interested.
Year(s) Of Engagement Activity 2012
 
Description Deary - Biomarkers workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The work was commissioned by the Medical Reseach Council. The result was a long, detailed and comprehensive set of guidelines for measuring ageing phenotypes in older people. From CCACE, Deary and Nissan did all the work which contributed to the cognitive assessment recommendations for older age.

The work has been written as an MRC report. Publication in peer-reviewed journal and wider distribution to scientists will follow.
Year(s) Of Engagement Activity 2012
 
Description Deary - British Academy British Psychological Society lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact British Academy Lecture - Intelligent Scotland-Godfrey Thomson and the Scottish Mental Surveys. Prof Ian Deary. 17 Oct 2012. This was attended by over 150 indivdiuals. The event was a sell-out and there was a spill over room used. The lecture is available on the Academy website.

The talk led to a lively question session dfrom both historians and scientific researchers. The talk has been viewd many times online and is being written up for the British Academy journal as a separate article.
Year(s) Of Engagement Activity 2012
 
Description Deary - British Academy Expert Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact With CCACE fellow-elect, Dr Stuart Ritchie, Ian Deary obtained funding for and organised this British Academy-funded workshop on processing speed and its importance for cognitive ageing in humans held in April 2014. Among the 13 attendees were international experts from the USA, Europe and the UK. Also, Professor James Goodwin for Age UK attended in order to achieve knowledge exchange and impact for the discussions.


All of the discussions were audio recorded and slides made available. There were several impacts. First, Ian Deary and Stuart Ritchie wrote a summary article for British Academy Review and this made available the questions and discussion on processing speed to other academics. Second, Professor James Thompson of University College London extensively reported several of the talks with their Powerpoint slides on his much-read psychology blog, which reaches academics and lay people. Third, Professor James Goodwin took the results and their impact back to Age UK with a view to discussing how these were relevant to Age UK's aims in helping older people.
Year(s) Of Engagement Activity 2014
 
Description Deary - COEN 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact About 50 people attended this 1 hour talk followed by about 20 minutes of questions.

There was a broad range of individuals interesetd in brain ageing, which led to several 2-way suggestions for additional work, some of which has resulted in further communication and collaboration.
Year(s) Of Engagement Activity 2012
 
Description Deary - Cafe Scientific 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact About 50 people attended for this discussion of ten issue to do with human cognitive ability. For each topic, Deary spoke for 5 minutes and took 5 monutes of discussion. All discussions had to be curtailed because of intense interest.

There was a clear high interest in the topics and the audience contributed much discussion. The overall result was excellent and increased awareness of new findings and research problems in the area of human cognitive function across the lifecourse.
Year(s) Of Engagement Activity 2012
 
Description Deary - Cafe Scientific 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Ten "quite interesting things" about human intelligence. Prof Ian Deary. Café Scientifique, Edinburgh. 18 Oct 2012. This was attended by about 60 people, filling the space available. Deary presented each of the 10 issues in a 5 minute presentation followed by 5 minutes of discussion.

The audience was very lively and interested, and learned a great deal about the measurement, consequences, and ageing of human intelligence.
Year(s) Of Engagement Activity 2012
 
Description Deary - Centre for Neuroscience, Strathclyde University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This broad talk on the Centre's research was attende by over 40 people, and followed by a lively question session for about 20 minutes.

This was an opporunity to discuss cognitive ageing and cognitive epidemilogy findings with a broad range of neuroscientists, who were interested in the findings.
Year(s) Of Engagement Activity 2012
 
Description Deary - David Bartholomew talk on Godfrey Thomson 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This was a talk in honour of David Bartholomew's research on statistics and intelligence. About 80 people attended.

There was a broad range of academics present, and the talk resultsed in an invitaiton for a further talk (at Winton Capital).
Year(s) Of Engagement Activity 2011
 
Description Deary - Edinburgh Alliance for Complex Trait Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact About 125 people attended this first meeting of Edinburgh's researchers on complex trait genetics. There was a good discussion after the talk and there were many conversations that followed as a wide range of genetics researchers came up with suggestions for other possible approaches.

The suggestions for further collaboration and approaches are being fololwed up. A subsequent meeting of this group has been help and there is strong momentum for it to conrinue.This means that the human work on genetics of cognitive ageing is informed by a wide range of geneticists who have pervously not been in contact.
Year(s) Of Engagement Activity 2012
 
Description Deary - Edinburgh Friendship centre 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact About 120 older people attended this 1 hour lecture, followed by 30 minutes of discussion.

Attendees were interested to hear about the factors that affect cognitive ageing in older people.
Year(s) Of Engagement Activity 2011
 
Description Deary - Fulbright Scholars 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Talk entitled "How intelligence affects life and vice versa" given to visiting Fulbright Scholars.

This very able group of individuals were interested to hear about CCACE's research and the Lothian Birth Cohorts. They asked many questions.
Year(s) Of Engagement Activity 2012
 
Description Deary - Garfield Weston Foundation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Supporters
Results and Impact The Garfield Weston Trustees were making decissions about which research projects to support. They decided to contribute £250,000 to the Disconnected Mind project.

Awareness among the Trustees of the importance of human cognitive ageing and the illiciting of a large monetary award for the research.
Year(s) Of Engagement Activity 2013
 
Description Deary - Genes and environment in cognition, Liverpool BNA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This was an invited talk followd by discussion attended by over 100 people.

This was part of a day aimed at examining environment-genetics interactions. The outcome was that it affected subsequent grant applications for Deary's cohorts.
Year(s) Of Engagement Activity 2012
 
Description Deary - Glasgow Centre for Population Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Invited seminar: Deary, I. J. (2014). Healthy cognitive ageing. Glasgow Centre for Population Health. Glasgow, UK, January. Ian Deary gave a talk on the follow-up studies of the Scottish Mental Surveys, especially the Lothian Birth Cohort studies of 1921 and 1936. It was described how these contribute to what we know about protective and risk factors for healthy cognitive ageing. The topic of dementia was also discussed. There was a lengthy question session afterwards and Professor Deary had drinks with the audience and had further discussion.

A video of the talk was placed on the GCPH website and has been viewed many times.
Year(s) Of Engagement Activity 2014
 
Description Deary - Healthy ageing LBC studies Inner Wheel Club Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Deary, I. J. (2014). Healthy ageing: clues from the Lothian Birth Cohorts of 1921 and 1936. The Inner Wheel Club of Edinburgh. Edinburgh, UK, February. Ian Deary gave a talk on the follow-up studies of the Scottish Mental Surveys, especially the Lothian Birth Cohort studies of 1921 and 1936. It was described how these contribute to what we know about protective and risk factors for healthy cognitive ageing. The topic of dementia was also discussed. There was a lengthy question session afterwards and Professor Deary took soup and sandwiches with the audience and had further discussion.

After this talk the organisers thought it was so important and successful that they passed on Professor Deary's details to other group organisers and subsequent invitations ensued.
Year(s) Of Engagement Activity 2014
 
Description Deary - Healthy cognitive ageing, York University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Ian Deary was invited to give a seminar on Healthy cognitive ageing at the University of York, October 2014.

Interest and enthusiasm shown by attendees, and increased knowledge of the work of the Centre and LBC studies. The host, Dr Gary Lewis, after discussion with Professor Deary, has established plans for a new collaboration with the Lothian Birth Cohort studies.
Year(s) Of Engagement Activity 2014
 
Description Deary - Humanist Society Scotland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Over 80 people attended a public lecture on the factors affecting social mobility. The talk lasted 1 hour and there was 1 hour of questions.

This important and topical issue was of great interest to the attendees, witnessed by the long discussion period.
Year(s) Of Engagement Activity 2012
 
Description Deary - LBC 1936 BBC Radio 4 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This was a long and clear story on the high-audience PM programme on radio 4. It gave a clear account of the Lothian Birth Cohort cognitive ageing research.

This programme has a large national and international audience. Even from the number of contacts we had from people who heard it, the feedback was very positive concerning how they conveyed our reseach and it prompted much discussion about cognitive ageing which we assume took place throughout the country.
Year(s) Of Engagement Activity 2013
URL http://www.bbc.co.uk/news/health-22767016
 
Description Deary - LBC1936 media stories 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact International interest from high-profile publications concerning the results which showed that brain grey matter-cognition associaiotns in old age could be explained by IQ tests taken 60 years ealier.

Stories in international publications which we assume have been read and discussed by very large numbers of individuals.
Year(s) Of Engagement Activity 2013
URL http://www.sciencedaily.com/releases/2013/06/130604135416.htm http://healthland.time.com/2013/06/06/...
 
Description Deary - Leith Probus Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Invited talk: Deary, I. J. (2013). The Lothian Birth Cohort 1936. Leith Probus Club. Edinburgh, UK, October. Ian Deary gave a talk on the follow-up studies of the Scottish Mental Surveys, especially the Lothian Birth Cohort studies of 1921 and 1936. It was described how these contribute to what we know about protective and risk factors for healthy cognitive ageing. The topic of dementia was also discussed. There was a lengthy question session afterwards and Professor Deary took tea with the audience and had further discussion.

After this talk the organisers thought it was so important and successful that they passed on Professor Deary's details to other group organisers and subsequent invitations ensued.
Year(s) Of Engagement Activity 2014
 
Description Deary - MRC Lifecourse Epidemiology Unit, Southampton 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Invited for a cross-Centre visit. This consisted of a 1-hour talk and a prolonged question session. Also, there were meetings with key scientists from the Unit.

This was a well-attended seminar and a lively question session. The meeting resulted in subsequent collaborations which have produced papers that originated in both Centres.
Year(s) Of Engagement Activity 2012
 
Description Deary - MRC Network spring 2014 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The MRC's publication, Network, published an article on Centre Director Ian Deary's workspace, which showcased the work of the Centre in spring 2014.

As is typical with these sorts of magazine-type articles, it attracted a lot of comment and attention, and many people, as a result, asked Professor Deary and colleagues about the history of the Scottish Mental Surveys and the work of the Lothian Birth Cohorts.
Year(s) Of Engagement Activity 2014
 
Description Deary - Marchmont St Giles Church Guild 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The audience were enthusiastic and asked many relevant questions about the cogntive ageing research.

Enthusiasm for and great awareness of the contributors to peoples differences in cognitive ageing and how these arise from across the full human lifecourse.
Year(s) Of Engagement Activity 2013
 
Description Deary - Nature - Genetic associations for human intelligence 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Press Release: Study Shows Genetic Associations for Human Intelligence. The first direct biological evidence for a genetic contribution to people's general cognitive abilities, reported in Molecular Psychiatry. Cconsiderable interest in the international press including the Guardian http://bit.ly/nXGcQT, Washington Post and New Deli Times.

Video: http://youtu.be/Y2ZXccfgWXk viewed 1,200 times in a year. Prof Ian Deary et al. Aug 2011.
Year(s) Of Engagement Activity 2012
 
Description Deary - Neuroscience Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This keynote talk was attended by about 300 neuroscience researchers, from undergraduate students to senior academics. There was a good question session after the talk.

This was an excellent opportunity to convey the genetic findings on cognitive ageing to the broadest range of neuroscience reseachers at Edinburgh, and led to further suggetions for possible candidate genes and genetic approaches to cognitive ageing which are being followed up.
Year(s) Of Engagement Activity 2012
 
Description Deary - Our Changing World lecture series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact To a sell-out audience of about 200, Deary described the changing demographic structure of the world, Europe, the UK, and Scotland. He described the incresae in dementia and cognitive delincearound the world. He described the research group's contribution to cognitive ageing research.

There was a lively discussion session which showed substantial interest and wished to know more about human cognitive ageing and its impact on the individual and society. This has been viewed on YouTube over 1300 times.
Year(s) Of Engagement Activity 2012
URL http://www.youtube.com/watch?v=DkCFXdt7Fhc
 
Description Deary - Pilrig St Paul's Guild 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Around 30 older people attended the talk and there were many questions and discussions after about successful cognitive ageing and the lifestyle associaioted with this.

Wider recognition of the contributions to healthy cognitive ageing. Appreciation of the unique nature of the research in Edinburgh.
Year(s) Of Engagement Activity 2013
 
Description Deary - Pilrig St Paul's Guild, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Invited talk: Deary, I. J. (2013). The Scottish Mental Surveys and healthy cognitive and brain ageing. Pilrig St Paul's Guild. Edinburgh, UK, November. Ian Deary gave a talk on the follow-up studies of the Scottish Mental Surveys, especially the Lothian Birth Cohort studies of 1921 and 1936. It was described how these contribute to what we know about protective and risk factors for healthy cognitive ageing. The topic of dementia was also discussed. There was a lengthy question session afterwards and Professor Deary took tea with the audience and had further discussion.

After this talk the organisers thought it was so important and successful that they passed on Professor Deary's details to other group organisers and subsequent invitations ensued.
Year(s) Of Engagement Activity 2014
 
Description Deary - PsySTAR annual summer school 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact This talk was attended by about 100 people, comprising medical doctors planning to do a PhD in psychiatry, and other researchers like Deary who were prospective supervisors.

Several attendees got in touch after the talk to discuss possible PhDs at the Centre and with the Lothian Birth Cohorts.
Year(s) Of Engagement Activity 2012
 
Description Deary - Reverse causation and psychological tests 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact About 50 cohort researchers attended this day-long series of talks on research methods for cohorts.

Researchers discussed the issues raised and used them to implement changes in cohort studies.
Year(s) Of Engagement Activity 2011
 
Description Deary - Roslin seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Attended by about 75 people, this braod-based talk on the Lothian Birth Cohorts was followed by about 20 minutes of questions.

A very interested audience from a range of disciplines, several of whom were in touch to talk about possible genetics collaborations.
Year(s) Of Engagement Activity 2012
 
Description Deary - Royal Society of Arts 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Royal Society of Arts Event: Life is a Marathon. Presentation of the "latest scientific thinking about increasing human longevity in terms of trends, training and persistence". Video of talk online. This was a sell-out event, attended by about 125 people. It was a pre olympics event looking at human ageing, including cognition.

>6,000 views on YouTube http://www.thersa.org/events/video/vision-videos/panel-discussion10. The wide range of attendees -- from scientist to general public -- made this a very effective forum for discussing human lifecourse issues, including the Centre's findings on cognition.
Year(s) Of Engagement Activity 2012
URL http://www.thersa.org/events/video/vision-videos/panel-discussion10
 
Description Deary - Scottish Parliament Cross-Party Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact The findings from the Birth Cohort Studies and the Centre for Cogntive Ageing and Cognitve Epidemiology are presented to this group and the implications for policy discussed. The group contains members of the Scottish Parliament, senior policy individuals from ageing-relevant charities, and a few academics.

This offers the Centre and its controbuting scientists a direct line to policy makers in Scotland with respect to issues affecting older people.
Year(s) Of Engagement Activity 2011,2012
 
Description Deary - Stewart Men's Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact To an audience of around 40 Deary described the cognitive ageing work using the Lothian Birth Cohorts. There were many quesiotns after the presentation.

There was obvious interest in and greater appreciation of the factors that contribute to peoples difference in cognitive and brain ageing.
Year(s) Of Engagement Activity 2013
 
Description Deary - Strictly Science exhibition 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Viewed to date by over 120 individuals, the video aims at novel ways to conduct human brain research in vivo.

The talk has now gained 120 video views on YouTube (http://youtu.be/hr91MTjuVFo).
Year(s) Of Engagement Activity 2013
 
Description Deary - The British Academy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The lecture was a sell out to about 200 people (including overflow). Deary addressed both organisation's audiences by talking about the history of his cognitive ageing work and also the most important findings have arisen from it.

From across the humanities and sciences divide it was clear that there was much interest in the Scottish Mental Surveys and their history and also the follow-up work on them that is contributing to our knowledge of cognitive ageing. There was a long quesiotn session afterwards and the lecture is online. It already has 265 views on YouTube.
Year(s) Of Engagement Activity 2012
URL http://www.britac.ac.uk/events/2012/An_Intelligent_Scotland.cfm
 
Description Deary - University of the Third Age 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact About 100 older people attended the talk to hear about the factors that affect cognitive ageing and wellbeing in old age. There was an extensive discussion session afterwards.

Information on cognitive ageing was conveyed to people for whom it was highly relevant.
Year(s) Of Engagement Activity 2012
 
Description Deary - Winton Capital Management 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact 'Professor Sir Godfrey Thomson and the Scottish Mental Surveys of 1932 and 1947.' Winton Capital. Oxford, UK, May. Prof Ian Deary. 11 May 2012. 60 employees.

This raised awareness among a group of highly quantitative workers in the finance industry about issues to do with cognitive ageing and the manipulation of datasets involved in the research.
Year(s) Of Engagement Activity 2012
 
Description Deary - World Congress on Active Ageing 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This was an invited symnposium on the work of the Lothian Birth Cohorts. Our work was given a 2-hour period, and the attendance was at capacity for the room (about 150). There were 5 talks from our group.

The audience was an excellent combination of researchers, practitioners, and general public. There was great interest in the cohort findings on cognitive ageing. The session resulted in a subsequent collaborative grant application to LLHW for a study on activity and sedentary behaviour and cognitive ageing.
Year(s) Of Engagement Activity 2012
 
Description Deary: invited keynote speaker, Aqmen Resources for Democracy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Deary, I. J. The Scottish Mental Surveys of 1932 and 1947: still important after all these years. Resources for Democracy: Celebrating Scottish Social Surveys (ESRC Festival of Social Science Event 2012), 9th November 2012, Scottish Parliament. Organised by AqMeN http://aqmen.ac.uk/.

Informed peers, parliamentarians, policymakers and potential collaborators from other social surveys across Scotland about the Lothian Birth Cohort and 6-Day Sample studies. Audience members showed great interest in the studies and several productive conversations were had as a result.
Year(s) Of Engagement Activity 2012
 
Description Disconnected Mind newsletter - 2013+ 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The Disconnected Mind project, which includes the Lothian Birth Cohort 1936 study and involves many of the Centre's members, produces a quarterly newsletter summarising study progress, impact and the latest research findings. This is distributed to approximately 126 funders and research collaborators across the UK.

The newsletter is sent to funders as well as research collaborators, and information on the study and its findings has been used by Age UK, the LBC1936 study's main funders, in their publications.
Year(s) Of Engagement Activity 2013,2014
 
Description Drop-in activity at the Edinburgh International Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Staff and students from CCACE hosted a drop-in activity stand at the National Museum of Scotland, with the theme: 'How Old Are You Really?' The aim was to draw attention to the many ways - other than chronological age - that researchers of ageing try to measure how old someone is. In a sign of how well received the stand was, there were queues to enter everyday due to reaching maximum visitor capacity.
Year(s) Of Engagement Activity 2009,2018
 
Description Edinburgh International Science Festival 2014 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CCACE held an interactive stall in the Museum of Scotland as part of the family drop-in activities at the Edinburgh International Science Festival 15th-19th April 2014. This was visited by over 2000 people over the course of the week, including Age UK's Chief Executive, Tom Wright. The stall and activities showcased the work of the Centre, particularly the Lothian Birth Cohort studies.

Children and parents were able to engage with many displays and objects relating to brain function and brain ageing. As in previous years many hundreds of people engaged with the Centre's representatives and illustrations of its work.
Year(s) Of Engagement Activity 2014
 
Description Edinburgh Speakers Festival - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The new Edinburgh Speakers Festival 2016 took place from 9th-11th September and our own CCACE Director was invited to be part of this year's prestigious line-up. Speakers covered a large variety of topics including cognitive ageing, devolution, politics, history, literature, fashion, Islam, capitalism, cycling, RBS, the Lockerbie bombing, whisky and women's equality, but all with a focus on Scotland. Ian's talk was entitled "Understanding Healthy Cognitive Ageing: Scotland's Unique Contribution" and took place on Saturday 10th September.

This is what Ian said about the event:

"Well" said Disconnected Mind Director Ian Deary, "That's the first time I have been on the same bill as Ken Livingstone and Ruth Davisdson! What an ecclectic programme." Ian spoke on healthy cognitive ageing to an audience at the Edinburgh Speakers Festival. Of course, the LBC1936's results were highlighted, with a focus on the likely protective factors for cognitive ageing. "There was a middle-aged finalist from this year's Brain of Britain Radio 4 show in the audience", said Ian, "so that was a good basis from which to explain how crystallised ability ages pretty well." As usual,the photos of Mr Scott and his brain images went down well with the enthusiastic attendees.
Year(s) Of Engagement Activity 2016
URL http://www.ccace.ed.ac.uk/node/327
 
Description Explorathon - Museum of Scotland 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The Centre was represented at Explorathon, an event at the Museum of Scotland held in September 2014. There were presentations about the human brain with a host of interactive objects and displays so that people understood about the brain function and ageing.

Interest and enthusiasm shown by members of the public at the event, including many young people, and increased awareness of the work of the Centre.
Year(s) Of Engagement Activity 2014
 
Description Frontiers BBC Radio 4 - LBC June 2014 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Results from the Lothian Birth Cohort studies were discussed by Ian Deary on BBC Radio 4's Frontiers programme, looking at the latest thinking about our brain power in old age. Robert Logie also discussed cognitive ageing on the programme.

The Lothian Birth Cohort studies were discussed alongside Cambridge studies and a provocative idea that there might be much less cognitive ageing than these studies suggest. As a result, there was discussion in the media, which reached the Centre, about the LBC studies.
Year(s) Of Engagement Activity 2014
 
Description Gow - Active Ageing conference talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Disconnected Mind. Presentation at the Active Ageing Conference, Hamilton, UK, 23rd May 2012.

Informed the public of our research.
Year(s) Of Engagement Activity 2012
 
Description Gow - Symposium presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact "Activity and cognitive ageing: a healthy mind in a healthy body?" Presentation in the symposium "What factors contribute to successful cognitive ageing?" (Organiser - I. J. Deary) at the 8th World Congress on Active Ageing, Glasgow, UK, 13th-17th August 2012.

Informed the public of current research.
Year(s) Of Engagement Activity 2012
 
Description Gow: Neuroprotective Lifestyles Press Coverage - 2012 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press coverage of published article. Including: BBC, Wall Street Journal, Dailymail, Scotsman, Fox News, CBS, New York Times, Medline.

International press coverage.
Year(s) Of Engagement Activity 2012
 
Description HMC conference - Stuart Ritchie 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact October 4 2016: gave a talk on intelligence generally, including LBC1936 data, to the HMC conference (audience: headteachers) in Stratford
Year(s) Of Engagement Activity 2016
 
Description Harris - DNA from peas 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Schools
Results and Impact ~50 children were involved in the workshop.

Increased interest in science among primary school pupils.
Year(s) Of Engagement Activity 2013
 
Description Healthy cognitive ageing - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Deary, I. J. (2016). Healthy cognitive ageing. Iain Whyte House Group. North Queensferry, UK, February.

Overview of general information on individual differences in human cognitive and brain ageing. Most examples taken from work on the Lothian Birth Cohorts of 1921 and 1936 and other cognitive ageing studies headed by Ian Deary at the University of Edinburgh. Followed by an extended question time raising additional points and ensuring understanding of the key messages.
Year(s) Of Engagement Activity 2016
 
Description Healthy cognitive ageing - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Deary, I. J. (2016). Healthy cognitive ageing. University of the Third Age Science Group. Edinburgh UK, March.

Overview of general information on individual differences in human cognitive and brain ageing. Most examples taken from work on the Lothian Birth Cohorts of 1921 and 1936 and other cognitive ageing studies headed by Ian Deary at the University of Edinburgh. Followed by an extended question time raising additional points and ensuring understanding of the key messages.
Year(s) Of Engagement Activity 2016
 
Description Healthy cognitive ageing and the Lothian Birth Cohorts of 1921 and 1936 - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Deary, I. J. (2016). Healthy cognitive ageing and the Lothian Birth Cohorts of 1921 and 1936. The Senior Fellows Club of the Royal Colleges of Physicians and Surgeons of Edinburgh. Edinburgh, UK, May.

Overview of general information on individual differences in human cognitive and brain ageing. Most examples taken from work on the Lothian Birth Cohorts of 1921 and 1936 and other cognitive ageing studies headed by Ian Deary at the University of Edinburgh. Followed by an extended question time raising additional points and ensuring understanding of the key messages.
Year(s) Of Engagement Activity 2016
 
Description Hosting work experience pupils 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact CCACE hosted a series of work experience placements for pupils in s5/6 (secondary school). Pupils were given the opportunity to meet with CCACE members and observe some of the work of the Centre, including brain imaging, cognitive testing, and public engagement.

These placements were a great success, with several schools expressing an interest in sending pupils to the Centre for work experience in the future.
Year(s) Of Engagement Activity 2014
 
Description Lifetimes event at Midlothian Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Discussion session about the history and current research relating to the Lothian Birth Cohorts, and a showing of the short film The Living Brainabout the Lothian Birth Cohorts. Followed by hands-on reaction time testing and demonstration of brain images/3D printouts.
~30 members of the public attended a talk and a Q and A session.

A great deal of interest in the Lothian Birth Cohort studies and multiple Q andA sessions with a very engaged audience.
Year(s) Of Engagement Activity 2014
URL http://midlothiansciencefestival.com/event/lifetimes/
 
Description Lothian Birth Cohort Study 1936 annual newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact The Lothian Birth Cohort Study 1936 produces and annual newsletter which is sent to a large mailing list of over 500 individuals. Most of those on the mailing list are study members of the LBC cohort. The newsletter lets them know of new results which their data has produced. It is sent out with the study Christmas card.
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,
 
Description Lothian Birth Cohort reunion April 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact A reunion for participants in the Lothian Birth Cohorts of 1921 and 1936 was held on April 17th 2014 in Edinburgh. Presentations were given by main Principal Investigators and study co-ordinator on the results of the study to date, and short presentations were given on offshoot studies including the 6-Day Sample study and the MRC-funded Seniors USP study from which Dr Philippa Dall presented. There was also a premiere of the film "The Living Brain" made by Anne Milne.

Participants enjoyed the day and were interested and engaged in the information presented. They were given the opportunity to ask questions towards the end of the day and a great range of questions were received and answered. Talks from the reunion are on YouTube http://youtu.be/v1v7mHGkkgI
Year(s) Of Engagement Activity 2014
URL http://youtu.be/v1v7mHGkkgI
 
Description Lyall - CCACE Stand 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Presented Centre for Cognitive Ageing and Cognitive Epidemiology stand at the World Conference on Active Ageing, August 2012

Attended by many at the conference, including general public, researchers, and policy makers and people from ageing charities.
Year(s) Of Engagement Activity 2012
 
Description Lyall - Edinburgh Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact MRC "Medical Detective" at Edinburgh Science Festival April 2012.

This was very well received by children and parents and raised awareness and discussion of how the mind works, including the effects of ageing.
Year(s) Of Engagement Activity 2012
 
Description MRC Festival of Medical Research 2016 - Brain Maze event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact In June 2016 CCACE opened its doors to the public for the second outing of our popular Brain Maze event. CCACE joined forces with the Centre for Regeneritive Medicine to put on the interactive open day event as part of the Medical Research Council's Festival of Medical Research.

The sell out event (around 50-60 people took part in some way) led people through the maze of corridors and rooms in the basement of the Department of Psychology, where CCACE is based. In each of the 11 rooms, the had 10 minutes to experience a different aspect of the ageing brain and body. Popular activities included a supermarket sweep game, shopping for the lifestyle factors which affect how our brain ages (like smoking) while busting a few myths (like the lack of effect of brain training). The Maze finished with a cafe where participants got the chance to speak with scientists and reflect on their experience of the Maze. One of the main comments was that, having spent 2 hours in the maze chatting to scientists, people would have liked more time in each room. A great endosement of the time and effort invested by CCACE and CRM staff and students.
Year(s) Of Engagement Activity 2016
URL http://www.ccace.ed.ac.uk/news-events/latest/maze2
 
Description MRC biomedical picture of the day Dec 2013 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The brain tractography image from a Lothian Birth Cohort participant and created by Dr Mark Bastin from CCACE and the Brain Research Imaging Centre at the University of Edinburgh and Dave Liewald from CCACE was featured as the Biomedical Picture of the Day on the MRC's website on 11th December 2013.

This website is the portal into the Medical Research Council's work and is seen by thousands of people from all over the world, including members of the public and policymakers as well as academics and funders.
Year(s) Of Engagement Activity 2013
 
Description Mad Hatters Grey Matter, Cambo Estate 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact CCACE was represented with a stall and activities at the Mad Hatters Grey Matter event held at Cambo Estate on 18th July 2014. Around 50-100 people participated in the hands-on activities available at the stall.

From the audience reaction, we judged that family groups of various ages were engaged with ideas about brain function and brain ageing. We have been invited back to conduct an event concerning the Centre's work with the Lothian Birth Cohorts in the new year 2015 and have agreed to do so.
Year(s) Of Engagement Activity 2014
 
Description Media coverage of EPSRC biomarkers for vascular dementia project, October 2014 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Publicity related to EPSRC biomarkers for vascular dementia project, October 27th 2014
Newspapers and online
o BBC News online (http://www.bbc.co.uk/news/uk-scotland-tayside-central-29758311)
o Guardian (http://www.theguardian.com/society/2014/oct/27/study-aims-to-spot-early-dementia-from-eye-exam)
o Times (https://www.thetimes.co.uk/tto/news/uk/scotland/article4248976.html)
o Daily Mail (http://www.dailymail.co.uk/health/article-2808897/Could-simple-eye-test-reveal-Alzheimer-s-Computer-software-analyses-changes-veins-arteries-spot-disease-early-stages.html?ITO=1490&ns_mchannel=rss&ns_campaign=1490)
o Daily Record
o Courier (http://www.thecourier.co.uk/news/health/eye-test-could-identify-alzheimer-s-1.648932)
o Scotsman (http://www.scotsman.com/news/health/eye-test-could-detect-early-stages-of-dementia-1-3584553)
o Herald (http://www.heraldscotland.com/news/home-news/viability-of-alzheimers-test-probed.25688100)
o Evening Telegraph (http://www.eveningtelegraph.co.uk/news/scotland/dundee-university-eye-test-could-identify-alzheimer-s-1.649011)
o STV News (http://news.stv.tv/east-central/297181-scottish-researchers-study-link-between-eye-tests-and-alzheimers/)
o Times of India (http://timesofindia.indiatimes.com/home/science/Eye-test-that-predicts-Alzheimers-years-before-its-symptoms-appear/articleshow/44947344.cms)
o OnMedica (http://www.onmedica.com/newsarticle.aspx?id=289fa059-e87c-46b3-abd4-2eaed1c470ff)
o Delhi Daily News (http://www.delhidailynews.com/news/Eye-test-to-predict-Alzheimers-years-before-its-appearance-1414410420/)
o E Canada Now (http://www.ecanadanow.com/health/2014/10/27/eye-tests-may-help-early-diagnose-alzheimers-disease/)
o Irish Independent (http://www.independent.ie/irish-news/health/eye-test-may-hold-the-key-to-detecting-alzheimers-30695237.html)
o Engineering & Technology magazine (http://eandt.theiet.org/news/2014/oct/alzheimers-software.cfm)
o Nursing Times (http://www.nursingtimes.net/nursing-practice/specialisms/neurology/simple-eye-test-could-speed-up-alzheimers-diagnosis/5076165.article)
o Huffington Post (http://www.huffingtonpost.co.uk/2014/10/27/alzheimers-disease-eye-test-_n_6052610.html)
o ITV News (http://www.itv.com/news/update/2014-10-27/eye-test-could-help-diagnose-alzheimers-disease/)

Television
o BCC Reporting Scotland
o STV News (http://player.stv.tv/programmes/news-at-six-dundee-tayside-full/)

Radio
o Wave 102
o Kingdom FM
o BBC Western Midlands
o BBC Gloucestershire
o BBC Herefordshire
o BBC 5Live
o BBC Radio Scotland Drivetime


There was considerable media coverage of this project, reaching a wide variety of public audiences.
Year(s) Of Engagement Activity 2014
 
Description National Museum of Scotland exhibition - LBC1936 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact From 8 July 2016, the National Museum of Scotland (Edinburgh) have unveiled a new exhibit, John Scott's brain.

LBC1936 participant, Mr John Scott saw his brain for the first time in January this year at the National Museum of Scotland's Collections Care Centre. STV and the LBC team were there to witness Mr Scott seeing a 3D print of his living brain, taken from MRI data captured as part of the Lothian Birth Cohort 1936 (LBC1936) study. The 3D print will go on display in the museum from 8 July 2016, along with a stunning representation of Mr Scott's white matter (tractography) etched in crystal glass. When asked how he felt about having his brain on display in the National Museum, Mr Scott said "It's great, I told my grandchildren, when I'm not here, you can go and see my brain!"


You can hear Mr Scott talking about his experience on STV News (from 15:30) at http://player.stv.tv/episode/36pt/news-at-six-edinburgh-east-full/thu-07-jan-6-00-pm/

Dr Simon Cox, MRC Imaging Fellow on the LBC1936 study, said "I am used to looking at brain images on the computer day-to-day, but seeing a real model of the brain's white matter connections in glass and the outer surface of the brain like this is a unique experience - they are incredibly striking objects".

The brain imaging in LBC1936 is overseen by CCACE Group Leaders Professor Joanna Wardlaw and Dr Mark Bastin of Edinburgh Imaging and suported by funding from Age UK and the MRC. The 3D models of the brain surface and white matter were developed by Dr Mark Bastin and Dave Liewald in collaboration with Sophie Goggins, Assistant Curator of Biomedicine at the National Museum of Scotland and the Edinburgh College of Art (3D printed model).

You can learn more about the exhibit and Mr Scott in an NMS blog by Sophie Goggins http://blog.nms.ac.uk/2016/01/08/the-lothian-birth-cohort-medical-imaging-in-our-new-galleries/
Year(s) Of Engagement Activity 2016
URL http://blog.nms.ac.uk/2016/01/08/the-lothian-birth-cohort-medical-imaging-in-our-new-galleries/
 
Description Penicuik University of the Third Age - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Penicuik U3A discuss healthy cognitive ageing
"It's always a good sign when they have to put out extra chairs," said Ian Deary, after his talk on 16th February to Penicuik's branch of the University of the Third Age. "They said they usually get 30-50 people, but I lost count after 60. It's great to see such enthusiasm for hearing about healthy cognitive ageing and the Lothian Birth Cohorts' contribution to that. I encouraged people in the audience to ask any questions as we went along, and they were good at that. However, there were lots more excellent questions and discussions at the end of the talk. They wanted to know the evidence about many things, including genetics, dementia, physical exercise, smoking, sleep and cognitive engagement. I was especially pleased, when I was having my tea and custard cream afterwards, when an audience member congratulated my team on demonstrating reverse causation for some potential factors in cognitive ageing!" We note that Ian cycled to and from Penicuik to give the talk, which we hope contributed a little towards keeping him sharp.
Year(s) Of Engagement Activity 2017
URL http://www.ccace.ed.ac.uk/node/342
 
Description Penke: Invited Talk - Berliner Kolloquium of the Daimler und Benz Stiftung on "Gene und Umwelt" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Genetische und neurowissenschaftliche Grundlagen der Entwicklung kognitiver Fähigkeiten. [Genetic and neuroscientific foundations of the development of cognitive abilities.]

NA
Year(s) Of Engagement Activity 2012
 
Description Penke: Invited Talk - DPPD 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Genetische und neurowissenschaftliche Grundlagen von Intelligenz und der Alterung kognitiver Fähigkeiten. [Genetic and neuroscientific foundations of intelligence and cognitive ageing.]

NA
Year(s) Of Engagement Activity 2011
 
Description Penke: Invited Talk - Deutschen Gesellschaft für Psychologie 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Genetische und neurostrukturelle Grundlagen von Intelligenz und der Alterung kognitiver Fähigkeiten. [Genetic and neurostructural foundations of intelligence and cognitive ageing.]

NA
Year(s) Of Engagement Activity 2012
 
Description Penke: Invited Talk - German Society of Human Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Genetic and neurostructural foundations of intelligence.

NA
Year(s) Of Engagement Activity 2012
 
Description Penke: Invited Talk - SPERN 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The evolutionary genetics of individual differences and the recalibration hypothesis.

NA
Year(s) Of Engagement Activity 2012
 
Description Penke: White Matter Integrity - Press Coverage - 2012 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact International press coverage in the media and printed press.

Additional radio interviews.
Year(s) Of Engagement Activity 2012
 
Description Prof Joanna Wardlaw feature in Health Matters magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A feature in Health Matters magazine, Winter 2018-2019 issue, P 24-25. Wardlaw, JM. "MRI scans of the brain".
Year(s) Of Engagement Activity 2019
 
Description Prof Joanna Wardlaw lecture "Brain Health: a small matter of the blood vessels" in Edinburgh, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Edinburgh Neuroscience Public Christmas Lecture 2018
Year(s) Of Engagement Activity 2018
 
Description Prof Joanna Wardlaw lecture "Where next for stroke research?" in Edinburgh, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact 6th Edinburgh Stroke Winter School, 18th-20th February 2019.
Year(s) Of Engagement Activity 2019
 
Description Professor Sir Godfrey Thomson exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A treasure trove of artefacts relating to this pioneering educational psychologist will be displayed at the Univeristy of Edinburgh from Friday 29th July until 29th October. Entrance to the exhibition is free, and it is open to the public.

Piles of intriguing ledgers and personal mementos will feature in an exhibition reconstructing the life and work of Professor Sir Godfrey Thomson. Sir Godfrey - who led the world's only nationwide IQ tests, in Scotland - was an innovative educator who firmly belived that educational opportunity should not be linked to social staus. From the 1920s onwards he advocated comprehensive education. Thomson was based at the Moray House School of Education, now part of the University of Edinburgh. His greatest legacy for today's researchers was to test the intelligence of almost every Scottish 11-year-old child in 1932, and again in 1947.

For the first time, the Scottish Mental Survey's unique ledgers will go on public view, with a selection of sample pages on show. The ledgers hold the world's only record of IQ-type scores from full national year-of-birth cohorts.

Sir Godfrey's findings have formed the basis of much of the cutting-edge research at the University of Edinburgh since the late 1990's into how the brain ages, led by Professor Ian Deary. His team studies the now-older people who took part in the Scottish Mental Surveys.

Ian has spent the past decade investigating Sir Godfrey's life, and in 2008 he rescued a mass of never-before-seen documents and objects from Thomson's family home in Edinburgh, just before it was demolished. A selection of those artefacts, portraits and documents feature in the exhibition, telling the story of who Sir Godfrey was and what his motivations were.

Ian Deary said: "Godfrey Thomson saw mental ability tests as an imperfect but useful means to give poor children a chance in life. He was determined to look past pupils' social status, and try to see their underlying ability. By all accounts he was modest, not motivated by money, and happy to share academic wins, which in part led him to fade from the history books. I'm delighted we are now able better to understand and evaluate the pioneering work of this multi-talented and elusive man."

8103 individuals visited the exhibition.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-36894717
 
Description QMRI Administrators Forum 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Professor Deary gave a talk on his research on human cognitive ageing to the senior administrative staff of various units in the University of Edinburgh's College of Medicine and Veterinary Medicine. It was a good opportunity to spread the word about the research to a group at the University who is neither academic nor student, but are important in helping the process of research to flow easily.
Year(s) Of Engagement Activity 2015
 
Description Ritchie - Infinite Monkey Cage, August 2014 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Centre member Stuart Ritchie participated as a panelist on BBC Radio 4's Infinite Monkey Cage programme, broadcast on 11 August 2014. In this, Ritchie discussed the nature, causes and consequences of people's intelligence differences, showcasing the work of the Centre and discussing causes of people's differences in cognitive ageing.

This programme has a large audience and the Centre's work on cognitive abilities and cognitive ageing will have been heard by a large number of people.
Year(s) Of Engagement Activity 2014
 
Description Roberts - PhD Autumn Training School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact In 2012, 2013 and 2014 the CCACE Scientific Administrator collaborated with Edinburgh Neuroscience to run an extremely successful PhD training school. The day long workshop was set up to introduce current PhD students to topics such as "writing up your research", "where to get funding after your PhD", "how to give a good presentation". Across the two years the workshop has been attended by around 100 PhD students. Several senior staff in CCACE and beyond took part, including a talk and panel discussion from the CCACE Director.

PhD students are now more confident in their research skills and have a better understanding of the options available to them once they have completed their studies. This includes new skills in grant application and fellowship application.
Year(s) Of Engagement Activity 2012,2013,2014
URL http://www.edinburghneuroscience.ed.ac.uk/autumnschool/2013/index.html
 
Description Royal College of Physicians 'Women in medicine: a celebration' project 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Royal College of Physicians (RCP)'s 'Women in medicine: a celebration' project is a free exhibition of specially commissioned photographic portraits to honour contemporary and historical women in medicine. The project showcased a number of today's leading female clinicians and the women from the history of medicine who have inspired them. Prof Joanna Wardlaw is featured in the project alongside someone who inspired her, Marie Sklodowska Curie: https://www.rcplondon.ac.uk/projects/outputs/women-medicine-joanna-wardlaw-and-marie-curie
Year(s) Of Engagement Activity 2017
URL https://www.rcplondon.ac.uk/events/women-medicine-celebration
 
Description STV coverage - LBC reunion 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact The LBC reunion, organised and facilitated by CCACE, was covered on STV news on 17th April 2014.

XXX
Year(s) Of Engagement Activity 2014
 
Description Science Magazine article 31st October 2014 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The work of the Centre, in particular the Lothian Birth Cohorts, was featured in a 4-page article in Science Magazine by Emily Underwood. This was published on 31st October 2014 and promoted through various social media outlets.

It is very unusual to have the world's top general science journal devote four pages to a single set of studies, i.e. our Lothian Birth Cohort studies. The prominence of this story meant that we obtained large numbers of national and international contacts indicating that they had seen and enjoyed the report, and wanted to know more about the studies.
Year(s) Of Engagement Activity 2014
URL http://www.sciencemag.org/content/346/6209/568.summary
 
Description Staying sharp in later life; your expert guide to ageing well 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 'Staying sharp in later life' is a plain-language guide developed by Age UK in collaboration with researchers at CCACE . It provides accessible summaries of the latest research on a range of subjects from exercise and brain training, to diet, smoking and alcohol. There is a print and online version of the guide.
Year(s) Of Engagement Activity 2015,2018
URL https://www.ageuk.org.uk/information-advice/health-wellbeing/mind-body/staying-sharp/
 
Description Sunday Morning With... the LBC1936 - Ian Deary 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Lothian Birth Cohort 1936 (LBC1936) got a good airing on BBC Radio Scotland on Sunday 26th February 2017. LBC1936 participant Margaret Macintosh and Study Director Ian Deary were interviewed by presenter Cathy MacDonald on the programme Sunday Morning With... "Cathy MacDonald was clearly very taken with the uniqueness and long-term nature of the LBC1936 sample and the importance and range of the findings", said Ian, "and so a piece that was planned to be 5-10 minutes long ran for about 20 minutes. It was great to hear Margaret's enthusiasm for the project, her reflections on what we do, and what we might add to the study." The radio piece was stimulated by the front-page article in The Times on 21st February 2017 which discussed the study on personality stability that was conducted on the LBC1936's sister study, the 6-Day Sample.
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/programmes/b08g5h5s#play
 
Description The Brain is wider than the sky exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The brain tractography image from a Lothian Birth Cohort participant and created by Dr Mark Bastin from CCACE and the Brain Research Imaging Centre at the University of Edinburgh and Dave Liewald from CCACE was featured at an outdoor exhibition of brain images in St. Andrews Square, Edinburgh called: 'The Brain - is wider than the sky'. This exhibition was curated by researchers from the University's Patrick Wild Centre for Research into Autism, Fragile X Syndrome and Intellectual Disabilities in partnership with the Scottish charity Mindroom.

The exhibition showcased world-leading research by Edinburgh University and it was an honour for the work of CCACE to be featured. It was on display in a prominent location in central Edinburgh from 7th June to 4th July 2014 from 8am to 8pm and was seen by thousands of people.
Year(s) Of Engagement Activity 2014
 
Description The Disconnected Mind quarterly newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Disconnected Mind newsletter is sent out quarterly to a mailing list of over 100 people. This details main results and highlights from the study.
Year(s) Of Engagement Activity 2008,2009,2010,2011,2012
 
Description The Scottish Mental Surveys and the Lothian Birth Cohorts - Judy Okely 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentation on factors related to healthy cognitive ageing to around 15 members of the Edinburgh Electrical Engineering Society, October 2018.
Year(s) Of Engagement Activity 2017,2018
 
Description Wardlaw - Invited Talk - Acute Stroke Imaging Event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact "Interpretation of the hyper-acute CT in stroke and how the imaging steps fit together in different locations" Better imaging and better outcomes for stroke patients: Acute Stroke Imaging Event, 17th May 2012, University of Stirling, Stirling.

NA
Year(s) Of Engagement Activity 2012
 
Description Wardlaw - Invited Talk - BrainStorm: The Interactive Neuro-Interventional Course 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact "State of the ART 2: Ischaemic Stroke" BrainStorm: The Interactive Neuro-Interventional Course, 19th June 2012, Edinburgh.

NA
Year(s) Of Engagement Activity 2012
 
Description Wardlaw - Invited Talk - Clinical Grand Round 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact "Small vessels in the brain cause big problems for society" Clinical Grand Round, 25th January 2012, Edinburgh Royal Infirmary, Edinburgh.

NA
Year(s) Of Engagement Activity 2012
 
Description Wardlaw - Invited Talk - European Confederation of Neuropathological Societie 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact "Neuroimaging of white matter disease" European Confederation of Neuropathological Societies CME Course "Leukoencephalopathies", 4th June 2012, Edinburgh


NA
Year(s) Of Engagement Activity 2012
 
Description Wardlaw - Invited Talk - Neuroscience Day 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact "One small vessel in the brain, one giant problem for Society?" Neuroscience Day 2012, 1st March 2012, Edinburgh.

NA
Year(s) Of Engagement Activity 2012
 
Description Wardlaw - Invited Talk - The Society of Radiologists in Training Annual Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact "New insights into the brain and vascular disease from imaging: why it's not just enough to be a radiologist" The Society of Radiologists in Training Annual Meeting, May 10th 2012, Edinburgh.

NA
Year(s) Of Engagement Activity 2012
 
Description Wardlaw - Invited Talk - UK Stroke Forum 2011 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact "Neuroradiological aspects of cerebral small vessel disease"

NA
Year(s) Of Engagement Activity 2011
 
Description Wardlaw - Physical activity and brain size 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Radio Scotland interview regarding Neurology paper on physical activity and brain size in October 2012.

Media interest.
Year(s) Of Engagement Activity 2012
 
Description Wardlaw: Invited Talk - British Society of Neuroradiologists 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact "Imaging in ageing. Common features, how do we interpret them and what do they mean?"

NA
Year(s) Of Engagement Activity 2011
 
Description What Keeps Us Sharp? - Alan Gow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact Presentation on factors related to brain health at the Age Scotland Edinburgh and Lothians Meeting of Older People's Groups and Organisations, Edinburgh, UK, 6th November 2018
Year(s) Of Engagement Activity 2018
 
Description What's in your head? schools workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact This was a workshop for 9-11 year olds called What's in your head? Staying connected, held between 17th and 19th March 2014. The workshops were attended by around 50 school pupils.

This importantly raised awareness of brain size and the ageing of the brain and mental skills among younger people.
Year(s) Of Engagement Activity 2014