PREDICTING MRI ABNORMALITIES WITH LONGITUDINAL DATA OF THE WHITEHALL II SUBSTUDY

Lead Research Organisation: University of Oxford
Department Name: Psychiatry

Abstract

With increasing age many people develop memory problems and depression. They are predicted by the same risk factors as heart attacks and strokes. We, therefore, believe that memory problems and depression in later life are found with brain changes typical of blood vessel disease. Typically, the brain white matter, where nerve fibre connections are located, is disturbed in its structure, and the grey matter shrinks, due to a loss of brain cells. Fortunately, the brain has a number of strategies to compensate for such damage. Interestingly, some areas of the brain become more active, as others, often nearby or connected, shrink. Brain plasticity thus seems to help keep the brain functioning, in spite of illness related shrinkage. This explains why brain shrinkage by itself does not help the diagnosis of depression or dementia: there is a large overlap in scan changes between patients and healthy volunteers. Only combining measures of brain damage and the amount of compensatory activity allows us to predict the actual deficit in brain function.
This general idea can be applied to dementia: initially areas in the brain responsible for memory (the hippocampus) start to shrink, memory is impaired, but people can still compensate for this by using strategies, such as memos or diaries. Later in the illness, as other (frontal) parts of the brain are affected, these compensation mechanisms fail, and dementia sets in. Similarly, higher quality fibre connections in people of high risk of depression appear to protect them from actually developing the illness.
We have developed a magnetic resonance scan lasting 45 minutes that allows us to collect information about brain shrinkage, white matter integrity, blood flow, resting and working brain networks. The Whitehall II study has examined 7000 civil servants over the last 25 years at yearly intervals, and has therefore information for all the risk factors mentioned above, as well as other information about social background, exercise and mental activity. This kind of information is usually not available for imaging studies, as people tend not to remember such information accurately. Combining long-term Whitehall II information from 800 people with our sensitive and informative MRI scanning sequence will allow us to examine the connection between risk factors and protective factors and brain changes. Furthermore, it will help us establish the effects of these brain changes on current mental state and performance, answering important questions about the natural history of depression and dementia.

Technical Summary

The programme will combine multi-modal imaging and cutting edge analysis of brain structure, brain perfusion, white matter integrity and brain function with a rich longitudinal data set, the Whitehall II cohort. Twenty-five year antecedent vascular and metabolic risk trajectories and morbidity, antecedent levels of physical and mental activity, baseline cognitive performance levels and 15-year slopes of memory decrement over time, history of depressed mood, genotype, and measured resilience will be used to model brain changes in 800 subjects. Hypotheses are predicated on the assumption that the brain responds adaptively to any age or illness-related lesion with compensating functional reorganization and repair that result in the restitution of cognitive and mental function and behaviour. Damage to this ?scaffolding structure?, e.g. by widespread vascular damage to executive brain networks, will lead to decompensation of function, and result in clinical presentation with e.g. dementia or depression. We would thus predict that highly functioning individuals may show structural or functional lesions in e.g. hippocampal networks, associated with an increase in activity in scaffolding (e.g. executive) networks. We further predict that such active protective mechanisms will be dependent on such antecedents as vascular risk related behaviour and (mental) activity, in addition to other factors less amenable to treatment and prevention. The presence of detailed and frequently sampled cohort data in the Whitehall II study allows for a unique prospective analysis of the effects of socio-demographic, physical and behavioural factors on brain integrity, and a powerful study design strategy that makes it possible to compare the two extreme expressions of a clinical feature (e.g. depression with first onset in the 60s versus no depressive symptoms over at least 25 years), by controlling and stratifying for potential confounders, such as the conventional variables age, gender and occupational level, but also crucial mechanistic factors, such as vascular risk. Short of a prospective interventional study this will be the most effective and efficient way of establishing time directed associations between socially important variables and brain structure and function in older age. Considering the crucial importance that the growing group of active over 60 year olds will have in society, and the effect that a small shift from disabled to able people will have in this part of society, this is important research.

Publications

10 25 50
 
Description Anya Topiwala - Alcohol and the Brain: Possible Policy Implications Behavioural Insights Team (Cabinet Office), London
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description EU Horizon 2020
Amount € 10,000,000 (EUR)
Funding ID 732592 - Lifebrain 
Organisation European Union 
Sector Public
Country European Union (EU)
Start 01/2017 
End 12/2021
 
Title Whitehall imaging protocol 
Description MRI protocol for Whitehall II study including brain structure, function and structural and functional connectivity 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2012 
Provided To Others? Yes  
Impact Use of protocol by other local research groups and adoption by UK biobank 
URL http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048583/
 
Description Collaboration within Lifebrain (Horizon 2020) 
Organisation University of Oslo
Department Centre for Lifespan Changes in Brain and Cognition
PI Contribution Expertise and scan/participant data
Collaborator Contribution This project is realized by a close collaboration of major European brain research centres and a small and medium-sized enterprise (SME). The 14 partners come from 8 countries: Denmark, Germany, Netherlands, Norway, Spain, Sweden, Switzerland and UK.
Impact A number of deliverables to the European Commission (http://www.lifebrain.uio.no/research/) -- Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain") European Psychiatry, Volume 47, January 2018, Pages 76-87
Start Year 2017
 
Description Controlling Structure Inducted Variations in Non-Invasive Perfusion MRI of Neurodegeneration 
Organisation University of Oxford
Department Oxford University Clinical Academic Graduate School (OUCAGS)
Country United Kingdom 
Sector Academic/University 
PI Contribution Summary of data requested from the Whitehall II study: • Multiple post labelling delay pseudo-continuous ASL datasets from 150 individuals. • Demographic information including: age, sex, educational level and cognitive scores. • T1 structural images from the same 150 individuals and the outputs from fsl_anat analysis, which has already been performed.
Collaborator Contribution Dr Flora Kennedy McConnell and Dr Michael Chappell (IBME - Department of Engineering Science) The Whitehall II dataset includes arterial spin labelling (ASL) data from 150 individuals, all of whom were over 60 years old at the time of scanning. As part of the EPSRC funded project 'Controlling Structure Inducted Variations in Non-Invasive Perfusion MRI of Neurodegeneration', we intend to perform analysis of the ASL data, and associated demographic information (age, sex, educational level and cognitive scores), both with and without the use of a partial volume correction (PVC) technique developed by Dr Michael Chappell. This work will be carried out to examine the sensitivity of partial volume corrected ASL analysis to differences in perfusion. The analysis will be performed both voxelwise and within pre-defined regions of interest to consider the utility of PVC in each case. From the Whitehall II data we will examine already established perfusion differences associated with age, sex etc. The outcome will contribute back to analysis of ASL within Whitehall II on novel hypotheses by providing a tested pipeline for group analysis which will include partial volume correction. Subsequently, we intend to use both the ASL data and associated T1 structural images to begin to understand and model the relationship between tissue structure and perfusion. The aim being to create atlases of normal perfusion and perfusion-structure models.
Impact not so far
Start Year 2018
 
Description Gait analysis Brookes 
Organisation Oxford Brookes University
Country United Kingdom 
Sector Academic/University 
PI Contribution Examination of study participants, Data sharing
Collaborator Contribution Provision of sensors, data analysis
Impact -
Start Year 2013
 
Description How do genes and lifestyle interact to maintoin youthful brains in older ages? 
Organisation McGill University
Department Stroke Prevention Clinic McGill University
Country Canada 
Sector Hospitals 
PI Contribution Provision of Whitehall II and imaging data.
Collaborator Contribution Prof Chakravarty Mallar (McGill University) Supervision of Dr Sana Suri in machine learning methods to analyse the above data.
Impact not yet
Start Year 2018
 
Description Inflammation Helsinki 
Organisation Finnish Institute of Occupational Health (FIOH)
Country Finland 
Sector Public 
PI Contribution Blood Collection and data sharing, hosting of doctoral RA
Collaborator Contribution Analysis of cellular inflammation response and -omics
Impact -
Start Year 2013
 
Description The association of carotid phenotypes and haemodynamics with cardiovascular, cognitive, MRI outcomes 
Organisation University College London
Department UCL Energy Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide outcome variables: - Cerebrovascular and cardiovascular events: similar to mortality data, cases of non-fatal coronary heart disease or non-fatal stroke are already available in the WHII study and have been recently validated (Kivimaki et al. Epidemiology. 2017 Sep; 28(5): 735-739). - Cognition: The cognitive test battery, introduced to the study in phase 5 and repeated in phases 7, 9, and 11 (27). The tests have good test-retest reliability (range 0.6-0.9), assessed in 556 participants and retested within three months in 1997-99. We will relate our exposure variable with the following cognitive domains: memory (assessed using a 20 word free recall test), executive function (assessed with the Alice Heim 4-I test), and fluency (assessed using measures of phonemic and semantic fluency (28)). In addition to three cognitive domains, a global cognitive score will be created incorporating all tests described above by firstly using the distribution of the first wave of cognitive data to standardise the raw scores for each domain to z scores (mean=0; standard deviation=1). We will summarise these z scores and restandardise them to yield the global score, an approach that minimises measurement error inherent in individual tests (29). - Brain outcomes: white matter hyperintensities, grey/white matter volume and microstructure, brain functional measures.
Collaborator Contribution John Deanfield (BHF Vandervell Professor of Cardiology at University College London) The scope of this study is to explore the relationship between carotid phenotypes, wave intensity analyses, and presence and burden of carotid plaques with the risk of cardiovascular events, cardiovascular outcomes, cognitive decline or MRI outcomes, as well as the ability of carotid parameters to modify the relationship between aortic stiffness and same outcomes. • Carotid phenotypes (carotid stiffness, distensibility, compliance, elastic modulus, wave intensity) are associated with the risk of cardiovascular events and mortality, as well as with the risk of cognitive decline or adverse brain outcomes • Carotid phenotypes modify the association between aortic pulse PWV and the risk of cardiovascular events, cardiovascular mortality and rate of cognitive decline
Impact None yet
Start Year 2018
 
Description Anya Topiwala - Alcohol and the Brain: Possible Policy Implications 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Anya Topiwala - Alcohol and the Brain: Possible Policy Implications Behavioural Insights Team (Cabinet Office), London
Year(s) Of Engagement Activity 2017
 
Description Anya Topiwala - Does Drinking Moderate Alcohol Harm Your Brain? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact International Congress, Royal College of Psychiatrists, Edinburgh
Year(s) Of Engagement Activity 2017
 
Description Anya Topiwala - Moderate Alcohol and Brain Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Junior Investigator Award at the 16th Congress of the European Society for Biomedical Research on Alcoholism (8th - 11th of October 2017), Heraklion, Crete, Greece.
Year(s) Of Engagement Activity 2017
URL http://www.esbra.com/
 
Description Anya Topiwala - White matter integrity implicated in cognitive resilience to hippocampal atrophy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Society of Biological Psychiatry Meeting "Networks and Complexity in Biology, Brain and Behaviour", San Diego, 18-20 May 2017
Year(s) Of Engagement Activity 2017
URL https://sobp.org/
 
Description Associations between Cognitive and Social Activity Engagement and the Ageing Brain 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Melis Anaturk - Associations between Cognitive and Social Activity Engagement and the Ageing Brain: a Systematic Review and Meta-Analysis of Structural MRI Studies. Alzheimer Research UK Annual Conference, London
Year(s) Of Engagement Activity 2018
URL https://www.alzheimersresearchuk.org/for-researchers/research-conference-2019/
 
Description Brain Image Banking Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The purpose of the workshop was to get key people who are already involved in brain image banks (or starting large scanning projects) or in health informatics, together, to foster further exchange and collaboration between image banks, discuss technical and ethical issues, core metadata, questions such as 'what is normal', to facilitate data sharing and discuss some of the interesting statistical information that is emerging about variation in brain structure with ageing, etc. In attendance about 50 people, including international and UK experts, imaging groups, researchers involved in the BraINS project from around Scotland and from local Informatics groups. The emphasis is on 'workshop' and all attendees will have a specific role, either as a speaker, chair, discussant, etc.

Development of various sharing guidelines and protocols
Year(s) Of Engagement Activity 2014
 
Description Dementia 2016 Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Annual Conference on clinical advances in dementia
Year(s) Of Engagement Activity 2016
URL http://www.dementiasconference.com/MAG/media/uploaded/EVMAG/event_139/MAH_Dementias16_4pp_REV_LR.pdf
 
Description Depression for not-yet medics 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Schools
Results and Impact Good student feedback 'didn't know psychiatry was so scientific'

Further requests for shadowing
Year(s) Of Engagement Activity 2014
 
Description Eniko Zsoldos - Mid-life composite physiological markers predict structural integrity measures in later life 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Organization for Human Brain Mapping, 25-29 June, Vancouver; funded by Guarantors of Brain Travel Grant
Year(s) Of Engagement Activity 2017
URL https://www.humanbrainmapping.org/i4a/pages/index.cfm?pageID=3734
 
Description Eniko Zsoldos Medium Blog 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact "A mindful approach to the year: will your brain thank you for it?" Medium Blog published as an attempt to answer questions submitted by members of the public to "The Big Brain Competition", part of the Oxford "Brain Diaries" exhibition.
Year(s) Of Engagement Activity 2018
URL https://medium.com/oxford-university/a-mindful-approach-to-the-year-will-your-brain-thank-you-for-it...
 
Description European Psychiatric Association Research Prizes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Anya Topiwala - Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study. Selected best in the category "Biological correlates and treatments of mental disorders" European Psychiatric Association Research Prizes 2018 at 26th European Congress of Psychiatry, Nice.
Year(s) Of Engagement Activity 2018
URL https://epa-congress.org/2018#.XF2l1TP7SCo
 
Description Karolinska/Calgary Symposium 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Prepared formal plans for collaboration

-
Year(s) Of Engagement Activity 2014
 
Description Klaus Ebmeier - Effects of life-long use of alcohol, sleep, diet & exercise on brains in 800 Whitehall scans acquired over the last 5 years. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact RCPsych Scottish Division, annual meeting
Year(s) Of Engagement Activity 2017
 
Description Klaus Ebmeier - Healthy Minds from 0-100 years: Optimising the use of European brain imaging cohorts - The LifeBrain 2017-2021 Project 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Talk at the Workshop on Schizophrenia and other mental disorders, University of Pisa 15-16 June 2017, University of Pisa, organised and supported by the EU
Year(s) Of Engagement Activity 2017
URL https://agenda.infn.it/conferenceDisplay.py?confId=12005
 
Description Klaus Ebmeier - Public engagement on Lifebrain Facebook page and interview 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Klaus Ebmeier - Public engagement see Lifebrain Facebook page (https://www.facebook.com/lifebrain.h2020), and interview (http://www.lifebrain.uio.no/about/lifebrain-researchers/klaus-p.-ebmeier/interview.html).
Year(s) Of Engagement Activity 2017
URL http://www.lifebrain.uio.no/about/lifebrain-researchers/klaus-p.-ebmeier/interview.html
 
Description Lille tripartite networks 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Recommendations on quality, feasibility and fundability of tripartite networks in the North of France

Funding of tripartite networks in the North of France
Year(s) Of Engagement Activity 2014
 
Description Mobility, brain structure and cognition in older adults 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact PhD student Naiara Demnitz selected to present a poster at STEM for Britain. House of Commons, London
Year(s) Of Engagement Activity 2018
URL http://www.setforbritain.org.uk/2018event.asp
 
Description Multiple Interviews (Anya Topiwala) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact BMJ Paper published 2017 with a current Altmetric Attention Score of 3204. This is the high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2018. For example, Altmetric has seen 291 news stories from 209 outlets. Altmetric has also seen 2586 tweets from 2340 users, with an upper bound of 5,669,781 followers. In comparison, the paper achieved rank 100 of all (9,010,248) Altmetric measured research outputs, rank 5 of 36,277 research outputs published in the BRITISH MEDICAL JOURNAL, rank 7 of all 259,882 research outputs of similar age, and rank 1 of 888 research outputs published in the BRITISH MEDICAL JOURNAL of similar age.
Year(s) Of Engagement Activity 2017,2018
URL http://www.bmj.com/content/357/bmj.j2353.long
 
Description Novel insights from structural and functional imaging in relation to dementia and cognitive decline 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact talk sparked questions and discussion afterwards

Invitation for further talks
Year(s) Of Engagement Activity 2014
 
Description Old Age Division Imaging Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact workshop sparked questions and discussion afterwards

invitations for similar workshops
Year(s) Of Engagement Activity 2014
 
Description Oxford Psychiatry Autumn School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Conference for junior doctors and medical students interest in psychiatry as a profession
Year(s) Of Engagement Activity 2016
URL https://www.psych.ox.ac.uk/news/oxford-psychiatry-autumn-school-2
 
Description Royal Society Voices of the Future 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Dr Sana Suri - invited to represent the Royal Society at "Voices of the Future" in Parliament, an event where early career scientists can discuss evidence-based policy with the UK's most senior policymakers.
Year(s) Of Engagement Activity 2018
URL https://www.rsb.org.uk/policy/policy-events/voice-of-the-future
 
Description Sana Suri - Awarded Alzheimer's Society's Rising Star in Dementia Research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Award Cermony: Alzheimer's Society's Rising Star in Dementia Research at the Alzheimer's Society's Conference, London on 18 May 2017
Year(s) Of Engagement Activity 2017
URL https://www.psych.ox.ac.uk/news/dr-sana-suri-awarded-alzheimer2019s-society-prize
 
Description Sana Suri - Cerebrovascular reactivity in young adults with a genetic risk for Alzheimer's disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk at Imaging Cerebral Physiology Conference, University of Cardiff
Year(s) Of Engagement Activity 2017
 
Description Sana Suri - Lifebrain interview 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sana Suri - Lifebrain interview on Website
Year(s) Of Engagement Activity 2017
URL http://www.lifebrain.uio.no/about/lifebrain-researchers/sana-suri/interview.html
 
Description Sana Suri - Public engagement see Lifebrain Facebook page 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sana Suri - Public engagement see Lifebrain Facebook page (https://www.facebook.com/lifebrain.h2020)
Year(s) Of Engagement Activity 2017
URL https://www.facebook.com/lifebrain.h2020
 
Description Sana Suri Medium Blog 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact "How is your lifestyle affecting your brain?" Medium Blog published as an attempt to answer questions submitted by members of the public to "The Big Brain Competition", part of the Oxford "Brain Diaries" exhibition.
Year(s) Of Engagement Activity 2017
URL https://medium.com/oxford-university/how-is-your-lifestyle-affecting-your-brain-43fb9d988a22
 
Description Sana Suri Oxford Curiosity Carnival 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Oxford Curiosity Carnival (https://www.psych.ox.ac.uk/news/department-of-psychiatry-researchers-join-the-curiosity-carnival)
Year(s) Of Engagement Activity 2017
URL https://www.psych.ox.ac.uk/news/department-of-psychiatry-researchers-join-the-curiosity-carnival
 
Description Sociodemographic and lifestyle risk and protective factors for dementia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Klaus Ebmeier - Sociodemographic and lifestyle risk and protective factors for dementia. International Congress Royal College of Psychiatrists, Birmingham NEC.
Year(s) Of Engagement Activity 2018
URL https://www.rcpsych.ac.uk/events/congress
 
Description Studienstiftung Greifswald Summer School 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Seminar format with 3 presentations by me and 17 by other (student) participants. Inreased understanding of psychiatry and depression and their relation to society in all participants

Several electives arranged.
Year(s) Of Engagement Activity 2014
URL http://en.wikipedia.org/wiki/Studienstiftung
 
Description Symposium "Predictors of clinical response in psychiatric disorders" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact talk sparked questions and discussion afterwards

invitation for further talks
Year(s) Of Engagement Activity 2014
 
Description Take care of your brain. A healthy brain in a lifespan perspective 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Dr Sana Suri - Take care of your brain. A healthy brain in a lifespan perspective. Annual Lifebrain Meeting Public Lecture, Oslo [http://litteraturhuset.no/arrangement/ta-vare-pa-hjernen/]
Year(s) Of Engagement Activity 2018
URL http://litteraturhuset.no/arrangement/ta-vare-pa-hjernen/
 
Description The Course on Dementia for European Psychiatric Association 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact talks sparked questions and discussion afterwards

requests for collaboration
Year(s) Of Engagement Activity 2013
 
Description The heart-brain link: mid-life cardiovascular risk for dementia predicts poor brain health 20 years later 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Dr Sana Suri - The heart-brain link: mid-life cardiovascular risk for dementia predicts poor brain health 20 years later. Alzheimer Society Annual Conference, London.
Year(s) Of Engagement Activity 2018
URL https://www.alzheimers.org.uk/dementia-professionals/conferences-and-events/alzheimers-society-annua...
 
Description Treating Depression 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Annual Conference on Treating Depression
Year(s) Of Engagement Activity 2016
URL http://www.magonlinelibrary.com/doi/abs/10.12968/hmed.2016.77.3.179
 
Description Using MRI scans as measures of biological ageing - the Whitehall II (Stress and Health) MRI Substudy Oxford Institute of Population Ageing Trinity Term 2017 Seminar Series 'Ageing, Wellbeing and Health', 25 May 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Interdisciplinary Talk Oxford Institute of Population Ageing Trinity Term 2017 Seminar Series 'Ageing, Wellbeing and Health', 25 May 2017
Year(s) Of Engagement Activity 2017
URL https://www.ageing.ox.ac.uk/
 
Description Verena Heise - APOE genotype affects volume but not iron content of subcortical structures in the UK Biobank population study (V Heise, F Alfaro-Almagro, K Miller, M Jenkinson, K P Ebmeier, S M Smith, C E Mackay) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk at Annual Conference of the Organization for Human Brain Mapping, 25-29 June, Vancouver.
Year(s) Of Engagement Activity 2017
URL https://www.humanbrainmapping.org/i4a/pages/index.cfm?pageID=3734