An Immunological Toolkit for Clinical Application
Lead Research Organisation:
Newcastle University
Department Name: Institute of Cellular Medicine
Abstract
Patients with rheumatoid arthritis (RA) suffer with joint pain and stiffness, and joint damage which leads to a reduced ability to carry out everyday tasks. Although these are the most obvious features of the disease, the root cause of the disease lies within the human immune system. At the moment we don?t fully understand the immune abnormalities that lead to RA but, if we did, this should help us to manage the disease better. It would become easier to make a diagnosis, as well as to determine whether a patient?s RA is likely to damage their joints in the future. Perhaps most importantly it would help us to design better drugs to combat the disease, and to better use the drugs that already exist. Something that we would really like to be able to do is to decide the most appropriate drug for each patient and a better understanding of the immune abnormalities would also help here.
Therefore our plans are to study, in detail, the immune system of patients with RA. This will involve taking blood from patients and running a panel of advanced laboratory tests on their white blood cells. We will compare the results we obtain with the immune changes in healthy individuals responding to a vaccine ? expecting some to be the same and some to be different. Our work is in three phases and, during the phases, we plan to slowly ?home in? on simple laboratory tests that will allow us to measure what is happening to the immune system in patients with RA. An exciting aspect of the work is that what is relevant to RA may also relate to other diseases (diabetes, multiple sclerosis, asthma) and to patients with an organ transplant. Therefore our results could have wide-ranging influence beyond improving the care of patients with RA
Therefore our plans are to study, in detail, the immune system of patients with RA. This will involve taking blood from patients and running a panel of advanced laboratory tests on their white blood cells. We will compare the results we obtain with the immune changes in healthy individuals responding to a vaccine ? expecting some to be the same and some to be different. Our work is in three phases and, during the phases, we plan to slowly ?home in? on simple laboratory tests that will allow us to measure what is happening to the immune system in patients with RA. An exciting aspect of the work is that what is relevant to RA may also relate to other diseases (diabetes, multiple sclerosis, asthma) and to patients with an organ transplant. Therefore our results could have wide-ranging influence beyond improving the care of patients with RA
Technical Summary
Current management of rheumatoid arthritis (RA) is based upon measurement of inflammation and tissue damage. However these are downstream consequences of immune dysregulation, and sub-optimal guides for managing patients and designing disease-modifying drugs. Our aim is to identify the key immune abnormalities that define RA and to develop an immunological toolkit: a set of functional and flow cytometry-based assays to study and monitor the dysfunctional immune system. A UK-wide collaboration of academic and industrial scientists will develop the toolkit, using regular discussions and workshops. Although current theory suggests that key immune abnormalities in RA should reside within T- or B- lymphocytes, lessons from other diseases suggest a discovery approach to be most appropriate, encompassing deep immunophenotyping of major peripheral blood immune and inflammatory cell subsets. Therefore in phase I purified CD4+ and CD8+ T-cells, B-cells, monocytes, NK cells and neutrophils will undergo: multiparameter flow cytometry for cell surface phenotype, intracellular cytokine and lineage transcription factor expression, and signalling pathways; transcriptional analysis using Affymetrix U219 microarrays; and small RNA sequencing. A well-defined subset (n=30) will subsequently undergo ultra-deep RNA sequencing, providing a complete picture of the RA transcriptome. We will study three sets of individuals: 30 healthy controls during an evolving vaccination response; 200 established RA patients, stratified for disease activity and disease duration; and 30 RA patients receiving abatacept (costimulation blockade). Hypothesis-generating phase I will provide a detailed signature of cells and pathways that characterise the RA immune system, and inform the design of customised, low-density array(s) (LDA), alongside the initial development of relevant in vitro immune function assays. In phase II these will be applied to 100 patients with recent onset inflammatory arthritis, sampled longitudinally, alongside a refined panel of flow cytometry protocols. Signals that are consistent between phases I and II will lead to further refinement of the in vitro assays ready for phase III, which encompasses proof-of-concept studies with novel therapeutic compounds, provided by industrial partners. Here the final immune toolkit will be ?road tested?, providing a secondary outcome measure that predicts conventional efficacy parameters. Success in this challenging programme will provide a novel portfolio of immune function assays, potentially applicable to RA but also other immunopathologies. Their widespread adoption and application across diseases will reinforce the successful image of UK translational immunological research. Intellectual property generated by the work will be protected for future exploitation as appropriate.
Organisations
- Newcastle University, United Kingdom (Collaboration, Lead Research Organisation)
- University of Edinburgh, United Kingdom (Collaboration)
- Takeda Pharmaceutical Company (Collaboration)
- Amgen Inc (Collaboration)
- Manchester University (Collaboration)
- Hospital de Madrid (Collaboration)
- Oslo University Hospital (Collaboration)
- University of Amsterdam (Collaboration)
- Chiltern International (Collaboration)
- University of Cambridge (Collaboration)
- AstraZeneca plc (Collaboration)
- University Medical Centre Nijmegen (Collaboration)
- Leiden University Medical Center (Collaboration)
- Leibniz Association (Collaboration)
- University of Nottingham (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Abbott (Collaboration)
- University of Leuven (Collaboration)
- Reade (Collaboration)
- UCB Pharma, Belgium (Collaboration)
- Janssen Pharmaceutica NV (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- University of Glasgow, United Kingdom (Collaboration)
- University of Birmingham, United Kingdom (Collaboration)
- Royal Berkshire Hospital (Collaboration)
- Pfizer Ltd (Collaboration)
- Versus Arthritis (Collaboration)
- Pfizer, United States (Collaboration)
- University Hospital of Erlangen (Collaboration)
- Tepnel Pharma Services (Collaboration)
- St. George Hospital (Collaboration)
- Addenbrooke's Hospital (Collaboration)
- King's College London, United Kingdom (Collaboration)
- University of Southampton, United Kingdom (Collaboration)
- University College London, United Kingdom (Collaboration)
- University of Tours (Collaboration)
- Utrecht University (Collaboration)
- Protagen AG (Collaboration)
- NIHR CRN staff and facilities throughout the UK (Collaboration)
- SomaLogic (Collaboration)
- Queen Mary, University of London, United Kingdom (Collaboration)
- Cardiff University, United Kingdom (Collaboration)
- Schlosspark-Klinik (Collaboration)
- Johnson & Johnson Ltd, United Kingdom (Collaboration)
- University of Sheffield, United Kingdom (Collaboration)
- University of Queensland, Australia (Collaboration)
- F. Hoffmann-La Roche AG (Collaboration)
- Sanofi (Collaboration)
- University of Bath, United Kingdom (Collaboration)
- National Institute for Health Research, United Kingdom (Collaboration)
- Apitope (Collaboration)
- University of Warwick, United Kingdom (Collaboration)
- Karolinska Institute, Sweden (Collaboration)
- University of Hertfordshire, United Kingdom (Collaboration)
- Sanquin (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- University of Auckland, New Zealand (Collaboration)
- Viapath (Collaboration)
- University of Leiden, Netherlands (Collaboration)
- Regional University Hospital of Tours (Collaboration)
- University of Leeds, United Kingdom (Collaboration)
- University Hospital Schleswig-Holstein -Kiel (Collaboration)
- Simomics Ltd (Collaboration)
- Bristol-Myers Squibb (Collaboration)
- European Translational Information and Knowledge Management Services (eTRIKS) (Collaboration)
- NHS London, United Kingdom (Collaboration)
- University of Manchester, Manchester, United Kingdom (Collaboration)
Publications

Alunno A
(2021)
EULAR points to consider on pathophysiology and use of immunomodulatory therapies in COVID-19.
in Annals of the rheumatic diseases

Anderson AE
(2019)
Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis.
in Rheumatology (Oxford, England)

Anderson AE
(2016)
IL-6-driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anticitrullinated peptide antibody-negative rheumatoid arthritis.
in Annals of the rheumatic diseases

Baker Kenneth F.
(2021)
Biomarkers of tolerance in immune-mediated inflammatory diseases: a new era in clinical management?
in LANCET RHEUMATOLOGY

Baker KF
(2020)
Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission.
in Therapeutic advances in musculoskeletal disease

Baker KF
(2017)
Let's not fool ourselves. In RA, the ACR/EULAR remission criteria are not perfect!
in Annals of the rheumatic diseases

Baker KF
(2019)
Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study.
in Journal of autoimmunity

Baker KF
(2021)
Biomarkers of tolerance in immune-mediated inflammatory diseases: a new era in clinical management?
in Lancet Rheumatology


Bluett J
(2014)
Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort.
in The pharmacogenomics journal
Description | A: Arthritis Research UK Disease Subcommittee Meeting, Chesterfield, 2018 |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
URL | https://www.versusarthritis.org/research/research-funding-and-policy/our-charitable-subcommittees/ |
Description | A: CLUSTER Consortium, London 2018 - Stratified Medicine in JIA and associated Uveitis |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
URL | https://www.arthritisresearchuk.org/research/grant-tracker-items/2018/personalised-treatment-for-chi... |
Description | A: NIHR ARUK Musculoskeletal Experimental Medicine Conference 2018, Nottingham 2018 |
Geographic Reach | National |
Policy Influence Type | Participation in a national consultation |
URL | https://www.arthritisresearchuk.org/research/news-for-researchers/2018/july/maximising-msk-experimen... |
Description | Arthritis Research UK Strategic Workshop - Stacking the Odds Towards a Cure - Versus Arthritis London 2018 |
Geographic Reach | National |
Policy Influence Type | Participation in a national consultation |
Description | Associate Medical Director for Research, Newcastle upon Tyne Hospitals NHS Foundation Trust |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | As Associate Medical Director for Research, I (with my senior leadership team) am developing a new strategy for research for Newcastle Hospitals. This will embed research into everyday care, and provide opportunities for research participation for all levels of hospital staff, linked to training programmes. It is well recognised that research leads to improved healthcare outcomes, and this new strategy should therefore improve the health of our local and regional population, as well as improve th training and knowledge of our staff. |
Description | BBA Forum Meeting London 2016 British Biosimilar Association Clinical Faculty |
Geographic Reach | National |
Policy Influence Type | Participation in a national consultation |
Description | Chair - EULAR STUDY GROUP ON THERAPEUTIC DRUG MONITORING OF BIOLOGICS |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
URL | https://www.eular.org/myUploadData/files/publication_document_therapeutic_drug_monitoring_study_grou... |
Description | Chair of the EULAR Task Force on Therapeutic Drug Monitoring of Biopharmaceuticals |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
Impact | EULAR Task Forces comprise a panel of experts and exist to develop guidelines based upon systematic literature reviews of current evidence on a particular topic. These are subsequently published, either as guidance or 'points to consider' (where evidence is less robust) and influence rheumatological practice around the world . This particular Task Force, which I chair, was established to develop guidance around the use of therapeutic drug monitoring in inflammatory rheumatic disease. Ultimately this work will educate the workforce and improve the cost effectiveness of healthcare services by ensuring such testing is implemented only where it is likely to be clinically useful and cost effective. |
URL | https://www.eular.org/eular_taskforce_ongoing_initiatives.cfm |
Description | Chairperson, MRC Cluster Consortium, London, 2019 |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
URL | https://www.clusterconsortium.org.uk/ |
Description | DMARDs and Cost Effective Prescribing. |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guideline committee |
Description | DRFZ SAB |
Geographic Reach | Europe |
Policy Influence Type | Participation in a advisory committee |
URL | https://www.drfz.de/en/ |
Description | Department of Health and Social Care Visit to NIHR Newcastle Biomedical Research Centre - Tony Soteriou |
Geographic Reach | National |
Policy Influence Type | Participation in a national consultation |
Description | EULAR 2020 Pivotal Events |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | As Scientific Chair of EULAR 2020, I chaired the committee responsible for developing an education and scientific programme of high quality and value. More than 15000 delegates attended this virtual event, which received more than 2 million website 'hits' during the four days of the congress. |
URL | https://congress2020.eular.org/scientific_programme.cfm |
Description | EULAR Consensus Meeting, Vienna, 2019 |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
Impact | This committee generated guidance for the use of a new class of drugs in patients with rheumatic diseases. |
Description | EULAR Scientific Committee |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | EULAR'S scientific committee is responsible for developing an education and scientific programme of high quality and value. More than 15000 delegates attend the annual meeting, which is recognised as one of the top two rheumatology congresses annually. I was chair of this committee in 2020 and, as past chair in 2021, continue to play an active role in the activities of the committee. |
URL | https://congress.eular.org/ |
Description | EULAR Task Force on pathophysiology and use of immunomodulatory therapies in COVID-19 |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a advisory committee |
Impact | EULAR Task Forces comprise a panel of experts and exist to develop guidelines based upon systematic literature reviews of current evidence on a particular topic. These are subsequently published, either as guidance or 'points to consider' (where evidence is less robust) and influence rheumatological practice around the world . This particular Task Force was established to develop guidance around the pathophysiology and use of immunomodulatory therapies in COVID-19. Publication: Alessia Alunno, Aurélie Najm, Pedro M Machado, Heidi Bertheussen, Gerd R Burmester, Francesco Carubbi, Gabriele De Marco, Roberto Giacomelli, Olivier Hermine, John D Isaacs, Isabelle Koné-Paut, César Magro-Checa, Iain McInnes, Pier Luigi Meroni, Luca Quartuccio, Athimalaipet V Ramanan, Manuel Ramos-Casals, Javier Rodríguez Carrio, Hendrik Schulze-Koops, Tanja A Stamm, Sander W Tas, Benjamin Terrier, Dennis G McGonagle, Xavier Mariette. EULAR points to consider on pathophysiology and use of immunomodulatory therapies in COVID-19. Ann Rheum Dis 2021 Feb 5;annrheumdis-2020-219724. doi: 10.1136/annrheumdis-2020-219724. Online ahead of print. PMID: 33547062 PMCID: PMC7871226 DOI: 10.1136/annrheumdis-2020-219724 Updated 2021: https://ard.bmj.com/content/81/1/34.long |
URL | https://ard.bmj.com/content/81/1/34.long |
Description | EULAR Task Force on the management of rheumatic and musculoskeletal diseases in the context of SARS-CoV-2 (member). |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
Impact | LAUNCH MEETING 7 APR 2020 and WEEKLY meetings thereafter. EULAR Task Forces comprise a panel of experts and exist to develop guidelines based upon systematic literature reviews of current evidence on a particular topic. These are subsequently published, either as guidance or 'points to consider' (where evidence is less robust) and influence rheumatological practice around the world . This particular Task Force was established to develop guidance for rheumatologists on the management if patients with rheumatic and musculoskeletal diseases during the COVID-19 pandemic. Publication: Landewé RB, Machado PM, Kroon F, Bijlsma HW, Burmester GR, Carmona L, Combe B, Galli M, Gossec L, Iagnocco A, Isaacs JD, Mariette X, McInnes I, Mueller-Ladner U, Openshaw P, Smolen JS, Stamm TA, Wiek D, Schulze-Koops H. EULAR provisional recommendations for the management of rheumatic and musculoskeletal diseases in the context of SARS-CoV-2. Ann Rheum Dis 2020 Jul;79(7):851-858. doi: 10.1136/annrheumdis-2020-217877. Epub 2020 Jun 5. PMID: 32503854 Guidelines updated November 2021: https://ard.bmj.com/content/early/2022/02/22/annrheumdis-2021-222006.long |
URL | https://ard.bmj.com/content/early/2022/02/22/annrheumdis-2021-222006.long |
Description | EULAR Task Force on the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guideline committee |
Impact | EULAR Task Forces comprise a panel of experts and exist to develop guidelines based upon systematic literature reviews of current evidence on a particular topic. These are subsequently published, either as guidance or 'points to consider' (where evidence is less robust) and influence rheumatological practice around the world . This particular Task Force was established to develop guidance on the use of a new class of therapeutics across a range of immune-mediated inflammatory diseases. Publication: Nash P, Kerschbaumer A, Dörner T, Dougados M, Fleischmann RM, Geissler K, McInnes I, Pope JE, van der Heijde D, Stoffer-Marx M, Takeuchi T, Trauner M, Winthrop KL, de Wit M, Aletaha D, Baraliakos X, Boehncke WH, Emery P, Isaacs JD, Kremer J, Lee EB, Maksymowych WP, Voshaar M, Tam LS, Tanaka Y, van den Bosch F, Westhovens R, Xavier R, Smolen JS. Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a consensus statement. Ann Rheum Dis 2021 Jan;80(1):71-87. doi: 10.1136/annrheumdis-2020-218398. Epub 2020 Nov 6. PMID: 33158881 |
Description | EULAR Task Force, Zurich |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
Description | MATCH Study Annual DMC |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a advisory committee |
Description | MHRA CTBVAG |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
Description | MHRA GRID advisory group |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
Description | MRC Informatics Meeting London 2016 |
Geographic Reach | National |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | MRC Stratified Medicine Leads met to discuss big data and data sharing in medical research. |
Description | MRC Methodology for Stratified Medicine |
Geographic Reach | National |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Guidance produced for the methodology to use when conducting precision medicine research. |
URL | https://mrc.ukri.org/research/initiatives/precision-medicine/stratified-medicine-methodology-framewo... |
Description | MRC Methodology for Stratified Medicine |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
Description | MRC Population and Systems Medicine Board |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
Description | MRC Precision Medicine Group |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
URL | https://mrc.ukri.org/research/initiatives/precision-medicine/ |
Description | MRC Precision Medicine Meeting |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Description | MRC Translational Research Group |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
URL | https://mrc.ukri.org/ |
Description | MRC Translational Research Group London 2018 |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
URL | https://mrc.ukri.org/about/our-structure/strategy-board-overview-groups/translational-research-group... |
Description | MRC Translational Research Group, London |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Description | MRC Translational Research Group, London, 2019 |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
URL | https://mrc.ukri.org/about/our-structure/strategy-board-overview-groups/translational-research-group... |
Description | MRC/ABPI Steering Group |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Description | Member, UKRI/ DHSC Oversight Committee for Covid-19 Immunology in the UK |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
URL | https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/8958... |
Description | Model collaborative parterships with industry |
Geographic Reach | National |
Policy Influence Type | Citation in other policy documents |
Description | NICE Assessment Sub-Group Meeting for the Diagnostics Assessment Programme, Manchester 2018 |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
URL | https://www.nice.org.uk/about/what-we-do/our-programmes/nice-guidance/nice-diagnostics-guidance |
Description | NICE Diagnostic Advisory Committee |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
URL | https://www.nice.org.uk/guidance/dg36 |
Description | NICE Diagnostic Advisory Committee Technology Assessment - monitoring of biologic drugs in patients with inflammatory arthritis |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Impact | The committee concluded that it was premature for the NHS to fund therapeutic drug monitoring until more evidence was generated for its cost-effectiveness . |
URL | https://www.nice.org.uk/guidance/dg36 |
Description | NICE Meeting |
Geographic Reach | National |
Policy Influence Type | Participation in a national consultation |
Description | NIHR BRC Impact Showcase, Newcastle, 2018 |
Geographic Reach | National |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Influential meeting on Healthy Ageing as a research priority of national importance, as exemplified by our NIHR BRC. |
URL | https://www.newcastlebrc.nihr.ac.uk/nihr-newcastle-biomedical-research-centre-impact-showcase-presen... |
Description | NIHR Bioresource Meeting |
Geographic Reach | National |
Policy Influence Type | Participation in a national consultation |
Description | Newcastle Audit Meeting |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Influenced training of practitioners or researchers |
Description | Newcastle Health Innovation Partners - Chair of the Research, Innovation & Enterprise Strategy Executive |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Participation in a advisory committee |
Impact | Newcastle Health Innovation Partners is Newcastle's Academic Health Science Centre, a partnership between Newcastle University, Newcastle upon Tyne hospitals, Cumbria, Northumberland, Tyne and Weir NHS Mental Health Trust, the Academic Health Science Network NE North Cumbria and Newcastle City Council. The aim of the research and innovation strategy group is to develop partnerships that accelerate the adoption of healthcare innovations that have developed from altranslation research activity either within the partner organisations themselves or in partnership with external collaborators. The ultimate aim is to improve the health, wealth and wellbeing of our regional population. We are already making advances in areas such as healthy ageing, rare diseases, advanced therapies and diagnostics. The COVID hub NE is a good example of a partnership that has the potential to improve the health of the local population by the rapid diagnosis and appropriate management of COVID-19 infection. |
URL | https://www.newcastlehealthinnovation.org/ |
Description | Office for Life Life Sciences Visit (Kristen McLeod) |
Geographic Reach | National |
Policy Influence Type | Participation in a national consultation |
Description | Oslo anti-TNF Tendering Meeting 2017 |
Geographic Reach | Europe |
Policy Influence Type | Gave evidence to a government review |
Impact | Tendering meeting to determine anti-TNF tariffs for the next two years. Keynote speaker. |
Description | TRC Steering Committee, London, 2018 with VA and NOCRI |
Geographic Reach | National |
Policy Influence Type | Participation in a national consultation |
Description | Tocilizumab clinical guidelines for British Society for Rheumatology |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guideline committee |
URL | http://rheumatology.oxfordjournals.org/content/53/7/1344.long |
Description | Translational Research Collaboration for Joint & related inflammatory diseases- Steering Committee Meeting |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
URL | http://www.nihr.ac.uk/life-sciences-industry/access-to-expertise-and-collaborations/collaborations-f... |
Description | Trustee and Board Member, Versus Arthritis |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Impact | The charity has influenced availability of regional services by providing or supporting some of these in partnership with regional government and healthcare providers. It has influenced public attitudes towards arthritis and related conditions via media campaigns. |
URL | https://www.versusarthritis.org/about-us/who-we-are/how-were-managed/trustees/ |
Description | Versus Arthritis Fellowship Expert Group |
Geographic Reach | National |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | The Versus Arthritis Fellowships Group, in addition to overseeing the award of a variety of Fellowship types to outstanding candidates, also has an influence on the Charity's Strategy with regard to education and training. An example is to ensure that Fellows receive sufficient resource to perform the research that they are planning. We also review the portfolio of fellowships on offer and decide, with the Charity's senior leadership, whether this remains current and appropriate. The terms of reference are as follows: i. to help monitor the provision of UK musculoskeletal training and identify gaps in support, where additional career support activities could add value ii. to take the role of chair or vice chair of Fellowship Funding Panels from time to time, overseeing the award of individual fellowships and studentships iii. to advise the charity on the balance of career support activities across the three Subcommittees iv. to help devise strategies to attract the brightest and most enthusiastic scientists, clinicians, nurses and allied health professionals into musculoskeletal research v. to advise on strategies to support individuals at different stages of their careers, using knowledge of career paths for all relevant areas vi. to help Versus Arthritis engage and work with others to increase musculoskeletal research capacity in the UK through the identification of potential funding and/or strategic partnerships vii. to contribute to discussion papers and reports on career support for consideration by the Subcommittees, Charitable Purposes Committee and charity Executive viii. to take learnings from the three Subcommittees as well as their expert area in order to make recommendations to the charity ix. to support the annual fellows meeting and propose other career events as appropriate. |
URL | https://www.versusarthritis.org/media/19590/feg-terms-of-reference.pdf |
Description | Versus Arthritis Fellowship Expert Group |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
Impact | Discussion around support for Fellows at various stages of their careers |
URL | https://www.versusarthritis.org/ |
Description | Versus Arthritis Tissue Engineering Scientific Advisory Board, Cambridge |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
URL | http://arthritistissueengineering.org.uk/ |
Description | Wellcome Trust 4WARD Meeting 2016 - Clinical PhD Funding - Newcastle, Leeds, Manchester, Sheffield |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Consortium Clinical PhD Funding Meeting |
URL | http://www.4wardnorth.org.uk/ |
Description | Wellcome Trust Clinical Interview Committee |
Geographic Reach | National |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | I was an ad hoc member of the Wellcome Trust selection committee for intermediate clinical fellowships on two occasions in 2020. These highly competitive fellowships are awarded to outstanding individuals based in a supportive environment to work on cutting edge scientific projects, ultimately improving the education and skill level of the workforce - these particular fellowships are required to incorporate a training element. |
URL | https://wellcome.org/grant-funding/guidance/funding-application-advisory-committees/clinical-intervi... |
Description | APIPPRA |
Amount | £66,120 (GBP) |
Funding ID | BH149466 |
Organisation | King's College London |
Department | School of Medicine KCL |
Sector | Academic/University |
Country | United Kingdom |
Start | 03/2015 |
End | 02/2019 |
Description | Abbvie Investigator initiated funding |
Amount | £109,465 (GBP) |
Funding ID | BH137913 |
Organisation | AbbVie Inc |
Sector | Private |
Country | United States |
Start | 12/2013 |
End | 09/2015 |
Description | Artificial Intelligence Multimorbidity Development Award |
Amount | £119,923 (GBP) |
Funding ID | NIHR202635 |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 01/2021 |
End | 10/2021 |
Description | BIOFLARE - Biological factors that limit sustained remission in Rheumatoid Arthritis |
Amount | £2,825,228 (GBP) |
Funding ID | MR/N026977/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 03/2019 |
Description | BRC Clinical Training Fellowship |
Amount | £60,000 (GBP) |
Organisation | National Institute for Health Research |
Department | NIHR Biomedical Research Centre |
Sector | Public |
Country | United Kingdom |
Start | 09/2016 |
End | 09/2019 |
Description | Bridging the third translational gap between industry and academia, creating a strong innovation culture at NU industry. |
Amount | £250,000 (GBP) |
Funding ID | MC_PC_17198 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 09/2019 |
Description | Characterising CD4+ T cell mediated mechanisms of genetic risk in the pathogenesis of rheumatoid arthritis - A Pratt, J Isaacs, L Reynard. |
Amount | £125,828 (GBP) |
Organisation | The JGW Patterson Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2015 |
End | 09/2019 |
Description | Development of a diagnostic and therapeutic response biomarker for patients with rheumatoid arthritis - Anderson, Pratt, Isaacs |
Amount | £73,325 (GBP) |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 08/2017 |
End | 09/2020 |
Description | EMINENT: Experimental Medicine Initiative to Explore New Therapies Fellowship |
Amount | £413,942 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2021 |
End | 10/2024 |
Description | EMINENT: Investigating Oncostatin M as a Mediator of Seronegative Inflammatory Arthritis |
Amount | £127,200 (GBP) |
Funding ID | MR/S50239X/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2018 |
End | 10/2019 |
Description | EU IMI2 (Rheuma Tolerance for Cure [RTCure]) - KCL |
Amount | € 6,000,000 (EUR) |
Funding ID | 777357 |
Organisation | European Commission |
Department | Innovative Medicines Initiative (IMI) |
Sector | Public |
Country | Belgium |
Start | 05/2017 |
End | 05/2022 |
Description | EU IMI2 (Rheuma Tolerance for Cure [RTCure]) - Newcastle |
Amount | € 6,000,000 (EUR) |
Funding ID | 777357 |
Organisation | European Commission |
Department | Innovative Medicines Initiative (IMI) |
Sector | Public |
Country | Belgium |
Start | 05/2017 |
End | 05/2022 |
Description | Elucidating the role of synovial fibroblasts in contributing to the pathogenesis of psoriatic arthritis - Isaacs & Nwosu |
Amount | £48,000 (GBP) |
Organisation | The JGW Patterson Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2019 |
End | 09/2019 |
Description | Immune-mediated inflammatory disease biobanks in the UK - IMIDBio_UK |
Amount | £218,084 (GBP) |
Funding ID | MR/R014191/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2017 |
End | 09/2020 |
Description | Investigation into Serum Type 1 Interferon as a Prognostic Marker of Clinical response in Early Rheumatoid Arthritis - Cooles & Isaacs |
Amount | £29,995 (GBP) |
Organisation | Academy of Medical Sciences (AMS) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2018 |
End | 08/2020 |
Description | Investigation into serum interferon-a as a prognostic marker of clinical response in early RA |
Amount | £15,143 (GBP) |
Organisation | British Society for Rheumatology (BSR) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2018 |
End | 08/2019 |
Description | Investigation into serum interferon-a as a prognostic marker of clinical response in early RA |
Amount | £15,100 (GBP) |
Organisation | British Society for Rheumatology (BSR) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2018 |
End | 09/2019 |
Description | Investigation of methotrexate metabolites in CD4+ T-Lymphocytes as a predictor of response to treatment in Rheumatoid Arthritis |
Amount | £263,289 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2017 |
End | 09/2020 |
Description | MATURA |
Amount | £550,614 (GBP) |
Funding ID | BH137922 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2014 |
End | 03/2018 |
Description | MRC DiMeN DTP Studentiship: What fundamental dysregulation of the immune system underpins the development of rheumatoid arthritis? |
Amount | £76,000 (GBP) |
Funding ID | 2117973 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2018 |
End | 09/2019 |
Description | NIHR Newcastle Biomedical Research Centre in Ageing and Long-term conditions |
Amount | £17,460,811 (GBP) |
Organisation | National Institute for Health Research |
Department | NIHR Biomedical Research Centre |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 03/2022 |
Description | NIHR Senior Investigator Award |
Amount | £360,000 (GBP) |
Funding ID | NIHR200224 |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 03/2019 |
End | 03/2023 |
Description | NIHR Translational Research Partnership |
Amount | £159,422 (GBP) |
Funding ID | BH122579 |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 08/2012 |
End | 09/2018 |
Description | Proximity to Discovery |
Amount | £250,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2015 |
End | 12/2016 |
Description | The Rheumatoid Arthritis Muscle Study RAMUS: JAK inhibition and rheumatoid cachexia |
Amount | £255,650 (GBP) |
Organisation | Pfizer Ltd |
Sector | Private |
Country | United Kingdom |
Start | 11/2018 |
End | 10/2020 |
Description | The role of somatic mutation in immune dsyregulation in rheumatoid arthritis - Collin, Anderson, Isaacs |
Amount | £73,325 (GBP) |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 08/2017 |
End | 09/2020 |
Description | Translation and Diagnostics - bridging the third translational gap |
Amount | £100,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 08/2018 |
Description | Using artificial intelligence (AI) to characterize the dynamic inter-relationships between MUltiple Long-term condiTIons and PoLYpharmacy and across diverse UK populations and inform health care pathways (AI-MULTIPLY). |
Amount | £2,900,000 (GBP) |
Funding ID | 31672 |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 03/2022 |
End | 09/2024 |
Title | RA-MAP Systems Model |
Description | Network-based and cross-platform models of response to treatment in rheumatoid arthritis. |
Type Of Material | Model of mechanisms or symptoms - human |
Year Produced | 2018 |
Provided To Others? | No |
Impact | Currently in development the model and data to be made available by 2020. |
URL | https://research.ncl.ac.uk/ra-map/ |
Title | The RA-MAP Immunological Toolkit |
Description | This development of this suite of immune biomarkers - the toolkit - is the major objective of the RA-MAP Consortium. It will be developed from biological material derived at 3 monthly intervals from TACERA study participants. |
Type Of Material | Biological samples |
Year Produced | 2018 |
Provided To Others? | No |
Impact | In progress. Ongoing collaborations to 1) validate MATURA methotrexate responders and 2) validate Newcastle interferon gene signature. |
URL | https://research.ncl.ac.uk/ra-map/ |
Title | Autoantibodies measured in plasma samples from the TACERA Study |
Description | A Luminex bead-based antigen array (Protagen-AG) was used to measure the autoantibody response against 192 human protein antigens at baseline and 6 months in plasma samples in early Rheumatoid Arthritis (RA) patients and healthy controls.
RA Patients recieved methotrexate at baseline. |
Type Of Material | Database/Collection of data |
Year Produced | 2020 |
Provided To Others? | Yes |
URL | https://figshare.com/articles/dataset/Autoantibodies_measured_in_plasma_samples_from_the_TACERA_Stud... |
Title | Autoantibodies measured in plasma samples from the TACERA Study |
Description | A Luminex bead-based antigen array (Protagen-AG) was used to measure the autoantibody response against 192 human protein antigens at baseline and 6 months in plasma samples in early Rheumatoid Arthritis (RA) patients and healthy controls. RA Patients recieved methotrexate at baseline. |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | TBD |
URL | https://figshare.com/articles/dataset/Autoantibodies_measured_in_plasma_samples_from_the_TACERA_Stud... |
Title | Clinical phenotype information for Rheumatoid Arthritis Patients and Healthy controls |
Description | Clinical phenotype for RA-Map (Early RA) and Vaccine recipient samples.
Access to clinical data is regulated by the RA-Map access committee. Please email m.r.barnes@qmul.ac.uk |
Type Of Material | Database/Collection of data |
Year Produced | 2020 |
Provided To Others? | Yes |
URL | https://figshare.com/articles/dataset/Clinical_phenotype_information_for_Rheumatoid_Arthritis_Patien... |
Title | Clinical phenotype information for Rheumatoid Arthritis Patients and Healthy controls |
Description | Clinical phenotype for RA-Map (Early RA) and Vaccine recipient samples.Access to clinical data is regulated by the RA-Map access committee. Please email m.r.barnes@qmul.ac.uk |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | TBD |
URL | https://figshare.com/articles/dataset/Clinical_phenotype_information_for_Rheumatoid_Arthritis_Patien... |
Title | Ecological Diversity Analysis of flow cytometry data |
Description | A novel method to measure diversity of immune cells in RA patients, which can be used to detect changes in the immune profiling over time and to categorise RA patients into a number of subgroups (eg remission / non-remission at 6 months) |
Type Of Material | Data analysis technique |
Year Produced | 2017 |
Provided To Others? | Yes |
Impact | None yet. Ongoing. |
Title | FEMERA: Functional Endotyping Model for Early RA - with SimOmics |
Description | Projection of multi-dimensional data onto two dimensions for consistency scoring and identification of TNF-reactive and Lymphocytic RA endotypes. |
Type Of Material | Computer model/algorithm |
Year Produced | 2017 |
Provided To Others? | Yes |
Impact | Application of a method developed by SimOmics permitting identification of endotypes in RA and mapping them to a systems model of RA. |
Title | IMID-BIO UK Database |
Description | Cross-consortia collaboration bringing together databases across the immune-mediated inflammatory diseases. |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | No |
Impact | Validation of MATURA methotrexate responder signature. Validation of Newcastle interferon gene signature. |
URL | https://www.gla.ac.uk/research/az/imid/studies/ |
Title | MedSciNet Electronic Data Capture for TACERA study |
Description | A study specific Electronic Data Capture (EDC) system has been designed for the TACERA study. This will be the electronic Case Record Form (eCRF) for the study as well as forming part of the Study Management system. The system will also automatically enrol patients once they have been deemed eligible. The EDC system is designed to follow the order of the study assessments and include all the clinical data (incl. Medication history, lifestyle factors questionnaire, DAS28 etc). |
Type Of Material | Database/Collection of data |
Year Produced | 2016 |
Provided To Others? | No |
Impact | The clinical dataset will be archived after the TACERA study closure and data will be available to other researchers upon request. |
Title | PRE-RA: Predictors of Remission in Early RA. |
Description | A cross-platform multi-omics model of predictors of remission for stratification of early RA patients. |
Type Of Material | Computer model/algorithm |
Year Produced | 2017 |
Provided To Others? | Yes |
Impact | In preparation. |
Title | RA-MAP Predictors of Remission - Pharma Trials |
Description | We have amalgamated 19 datasets provided by the pharmaceutical industry into a single dataset. This required understanding and harmonisation of variables as well as re-anonymisation of the individual components of the dataset. |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | No |
Impact | The datasets will be provided to the MRC Biostatistics Unit at Cambridge. They are now working on identification of predictors of remission or a remission trajectory. Draft paper to be submitted Q2 2017. Second paper on transcriptomics data to be submitted Q2 2017. Multi-omics and additional papers in preparation for publication 2017-2018. |
Title | RA-MAP-UNIVERSE |
Description | The GitHub repository for the RA-MAP project. ALL data and code permitting prediction of remission in early arthritis patients to be made available to the wider research community. |
Type Of Material | Database/Collection of data |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | TBD |
URL | https://github.com/RA-MAP-UNIVERSE |
Title | Raw somascan abundances of proteins measured in plasma samples from the TACERA Study |
Description | Raw abundances of proteins measured at baseline and 6 months in plasma samples in early Rheumatoid Arthritis (RA) patients from the TACERA Study.Patients recieved methotrexate at baseline. |
Type Of Material | Database/Collection of data |
Year Produced | 2020 |
Provided To Others? | Yes |
URL | https://figshare.com/articles/dataset/Raw_somascan_abundances_of_proteins_measured_in_plasma_samples... |
Title | TranSMART RA-MAP Multiomics database. |
Description | The Innovative Medicines Initiative eTRIKS team have provided technical support to the RA-MAP informatics team (Mike Barnes lead) to assist in the deployment of an open source datamart (TranSMART) for the RA-MAP projects. The TranSMART provides a useful repository tool for important data (patient clinical data, transcriptomics, metabolomics etc) that are acquired from the RA-MAP projects. The RA-MAP TranSMART is now operational and enabling secure data sharing between consortium members. |
Type Of Material | Database/Collection of data |
Year Produced | 2014 |
Provided To Others? | Yes |
Impact | The Barnes team have propagated the support provided for RA-MAP to enable the deployment of additional TranSMART datamarts for the MRC-PSORT and MRC-MATURA projects. This has created a unique, common datamarts infrastructure across three closely related MRC projects investigating immune-inflammatory disease, creating opportunities for future data integration ad integrated analysis for stratified medicine and drug discovery. [Updates from March 2016] We are sharing curated public data in the database with the MRC-MATURA, MRC-PSORT and IMI-etriks projects Knowledge sharing and troubleshooting between these projects has enabled more rapid data curation and data infrastructure development for the project. We have also provided advice and troubleshooting on TranSMART configuration to the MRC-CHART (Juvenile Idiopathic Arthritis) and MRC-Masterplan (SLE) consortia [Updates from March 2017] As a complex, highly curated dataset, the RA-Map TranSMART is serving as an exemplar for development of TranSMART for the the MRC-MATURA, MRC-PSORT and MRC-MASTERPLANS projects. The project is also being used as a successful exemplar for multiple MRC stratified medicine applications. |
Description | ARUK Centre of Excellence in rheumatoid arthritis pathogenesis |
Organisation | University of Birmingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | WE have written a successful funding application to Arthritis Research UK for a Centre of Excellence in RA pathogenesis, value £2.5m over five years |
Collaborator Contribution | Each centre will provide a unique scientific contribution to the Centre |
Impact | Research grant, valu £2.5m spread across the three centres. Renewed 2019 with addition of KIR, Oxford University |
Start Year | 2013 |
Description | ARUK Centre of Excellence in rheumatoid arthritis pathogenesis |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | WE have written a successful funding application to Arthritis Research UK for a Centre of Excellence in RA pathogenesis, value £2.5m over five years |
Collaborator Contribution | Each centre will provide a unique scientific contribution to the Centre |
Impact | Research grant, valu £2.5m spread across the three centres. Renewed 2019 with addition of KIR, Oxford University |
Start Year | 2013 |
Description | ARUK-NIHR Newcastle Experimental Arthritis Treatment Centre 2016 |
Organisation | Versus Arthritis |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Clinical, imaging, statistical and bioinformatics support. |
Collaborator Contribution | Infrastructure support including laboratory technical support, research nurses, project management, biostatistical and database management support. This has been crucial in tendering for other awards and trials. |
Impact | See Publications |
Start Year | 2012 |
Description | ARUK/NIHR Musculoskeletal Experimental Medicine Conference, Nottingham, 2018 |
Organisation | NIHR CRN Staff and Facilities Throughout the UK |
Country | United Kingdom |
Sector | Public |
PI Contribution | Contributor to discussions on the UK experimental and translational medicine landscape for rheumatology. Useful networking platform whose major function was to identify potential bottlenecks across infrastructure, regulation and PPI. |
Collaborator Contribution | Contributor to discussions on the UK experimental and translational medicine landscape for rheumatology. |
Impact | Versus Arthritis are making a financial contribution to the NIHR NOCRI TRC in Inflammatory and Joint Diseases |
Start Year | 2018 |
Description | ARUK/NIHR Musculoskeletal Experimental Medicine Conference, Nottingham, 2018 |
Organisation | Versus Arthritis |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Contributor to discussions on the UK experimental and translational medicine landscape for rheumatology. Useful networking platform whose major function was to identify potential bottlenecks across infrastructure, regulation and PPI. |
Collaborator Contribution | Contributor to discussions on the UK experimental and translational medicine landscape for rheumatology. |
Impact | Versus Arthritis are making a financial contribution to the NIHR NOCRI TRC in Inflammatory and Joint Diseases |
Start Year | 2018 |
Description | COST consortium |
Organisation | University of Warwick |
Department | Health Sciences Research Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | This is a new European network on tolerogenic cell therapies. The network is funded by COST (European Cooperation in Science and Technology) and is called 'Action to Focus and Accelerate Cell-based Tolerance-inducing Therapies' (A FACTT). Co-applicant Hilkens was one of the initiators of this network, and she is leading the tolerogenic APC workgroup. The main objective of A FACTT is to coordinate European cell-based tolerogenic therapy efforts to minimise overlap and maximise comparison of the diverse approaches through establishment of consensus monitoring parameters. More information can be found on: http://www.afactt.eu/ |
Collaborator Contribution | Co-applicant Hilkens was one of the initiators of this network, and she is leading the tolerogenic APC workgroup. The main objective of A FACTT is to coordinate European cell-based tolerogenic therapy efforts to minimise overlap and maximise comparison of the diverse approaches through establishment of consensus monitoring parameters. |
Impact | Several workshops have been held to date. |
Start Year | 2013 |
Description | CRO Chiltern Programme |
Organisation | Chiltern International |
Country | United Kingdom |
Sector | Private |
PI Contribution | n/a |
Collaborator Contribution | In 2013 Chiltern Activate was employed to facilitate TACERA study (early RA longitudinal study, a part of RA-MAP consortium) set up, which resulted in significant improvement of recruitment process. From 1st April 2014 the Clinical Monitoring team at Chiltern has been re-engaged to support recruitment at poorly performing sites. |
Impact | The RA-MAP consortium benefitted from this professional partnership by Chiltern's experience in facilitation of clinical study set up and recruitment processes. |
Start Year | 2013 |
Description | EMINENT: Experimental Medicine Initiative to Explore New Therapies |
Organisation | GlaxoSmithKline (GSK) |
Country | Global |
Sector | Private |
PI Contribution | Fortnightly TCs to discuss strategy. Assessment of EoIs, leading to prioritization of experimental studies. Development of potential portfolio studies. Supervision of EMINENT clinical Fellow. Attendance at science days. |
Collaborator Contribution | University College London (UCL), the University of Cambridge, the University of Glasgow, the University of Newcastle, Imperial College London and GlaxoSmithKline (GSK), with unprecedented access to GSK's unlicenced clinic-ready asset portfolio to enable experimental medicine studies aimed at enhancing understanding of disease mechanisms and accelerating development of novel therapeutics for patients in under-served disease areas. |
Impact | Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities. Mehta P, Porter JC, Manson JJ, Isaacs JD, Openshaw PJM, McInnes IB, Summers C, Chambers RC. Lancet Respir Med. 2020 Aug;8(8):822-830. doi: 10.1016/S2213-2600(20)30267-8. Epub 2020 Jun 16. PMID: 32559419 |
Start Year | 2019 |
Description | EMINENT: Experimental Medicine Initiative to Explore New Therapies |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Fortnightly TCs to discuss strategy. Assessment of EoIs, leading to prioritization of experimental studies. Development of potential portfolio studies. Supervision of EMINENT clinical Fellow. Attendance at science days. |
Collaborator Contribution | University College London (UCL), the University of Cambridge, the University of Glasgow, the University of Newcastle, Imperial College London and GlaxoSmithKline (GSK), with unprecedented access to GSK's unlicenced clinic-ready asset portfolio to enable experimental medicine studies aimed at enhancing understanding of disease mechanisms and accelerating development of novel therapeutics for patients in under-served disease areas. |
Impact | Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities. Mehta P, Porter JC, Manson JJ, Isaacs JD, Openshaw PJM, McInnes IB, Summers C, Chambers RC. Lancet Respir Med. 2020 Aug;8(8):822-830. doi: 10.1016/S2213-2600(20)30267-8. Epub 2020 Jun 16. PMID: 32559419 |
Start Year | 2019 |
Description | EMINENT: Experimental Medicine Initiative to Explore New Therapies |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Fortnightly TCs to discuss strategy. Assessment of EoIs, leading to prioritization of experimental studies. Development of potential portfolio studies. Supervision of EMINENT clinical Fellow. Attendance at science days. |
Collaborator Contribution | University College London (UCL), the University of Cambridge, the University of Glasgow, the University of Newcastle, Imperial College London and GlaxoSmithKline (GSK), with unprecedented access to GSK's unlicenced clinic-ready asset portfolio to enable experimental medicine studies aimed at enhancing understanding of disease mechanisms and accelerating development of novel therapeutics for patients in under-served disease areas. |
Impact | Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities. Mehta P, Porter JC, Manson JJ, Isaacs JD, Openshaw PJM, McInnes IB, Summers C, Chambers RC. Lancet Respir Med. 2020 Aug;8(8):822-830. doi: 10.1016/S2213-2600(20)30267-8. Epub 2020 Jun 16. PMID: 32559419 |
Start Year | 2019 |
Description | EMINENT: Experimental Medicine Initiative to Explore New Therapies |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Fortnightly TCs to discuss strategy. Assessment of EoIs, leading to prioritization of experimental studies. Development of potential portfolio studies. Supervision of EMINENT clinical Fellow. Attendance at science days. |
Collaborator Contribution | University College London (UCL), the University of Cambridge, the University of Glasgow, the University of Newcastle, Imperial College London and GlaxoSmithKline (GSK), with unprecedented access to GSK's unlicenced clinic-ready asset portfolio to enable experimental medicine studies aimed at enhancing understanding of disease mechanisms and accelerating development of novel therapeutics for patients in under-served disease areas. |
Impact | Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities. Mehta P, Porter JC, Manson JJ, Isaacs JD, Openshaw PJM, McInnes IB, Summers C, Chambers RC. Lancet Respir Med. 2020 Aug;8(8):822-830. doi: 10.1016/S2213-2600(20)30267-8. Epub 2020 Jun 16. PMID: 32559419 |
Start Year | 2019 |
Description | EMINENT: Experimental Medicine Initiative to Explore New Therapies |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Fortnightly TCs to discuss strategy. Assessment of EoIs, leading to prioritization of experimental studies. Development of potential portfolio studies. Supervision of EMINENT clinical Fellow. Attendance at science days. |
Collaborator Contribution | University College London (UCL), the University of Cambridge, the University of Glasgow, the University of Newcastle, Imperial College London and GlaxoSmithKline (GSK), with unprecedented access to GSK's unlicenced clinic-ready asset portfolio to enable experimental medicine studies aimed at enhancing understanding of disease mechanisms and accelerating development of novel therapeutics for patients in under-served disease areas. |
Impact | Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities. Mehta P, Porter JC, Manson JJ, Isaacs JD, Openshaw PJM, McInnes IB, Summers C, Chambers RC. Lancet Respir Med. 2020 Aug;8(8):822-830. doi: 10.1016/S2213-2600(20)30267-8. Epub 2020 Jun 16. PMID: 32559419 |
Start Year | 2019 |
Description | EU IMI IDEA-FAST Consortium |
Organisation | Newcastle University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | This Consortium is studying fatigue across inflammatory diseases including rheumatoid arthritis, SLE and Sjogren's Syndrome |
Collaborator Contribution | We are co-investigators in studies of RA and SLE and will also recruit patients with Sjogren's to some studies |
Impact | This is a multi-partner consortium with involvement of industry and investigators across the EU under the leadership of Newcastle |
Start Year | 2019 |
Description | EULAR Task Force on Therapeutic Monitoring of Biologics |
Organisation | Hospital de Madrid |
Country | Spain |
Sector | Hospitals |
PI Contribution | Chair the Study Group. Proposed EULAR Task Force with multiple academic and industry partners. |
Collaborator Contribution | TBD |
Impact | TBD |
Start Year | 2019 |
Description | EULAR Task Force on Therapeutic Monitoring of Biologics |
Organisation | Manchester University |
Country | United States |
Sector | Academic/University |
PI Contribution | Chair the Study Group. Proposed EULAR Task Force with multiple academic and industry partners. |
Collaborator Contribution | TBD |
Impact | TBD |
Start Year | 2019 |
Description | EULAR Task Force on Therapeutic Monitoring of Biologics |
Organisation | NHS London |
Country | United Kingdom |
Sector | Public |
PI Contribution | Chair the Study Group. Proposed EULAR Task Force with multiple academic and industry partners. |
Collaborator Contribution | TBD |
Impact | TBD |
Start Year | 2019 |
Description | EULAR Task Force on Therapeutic Monitoring of Biologics |
Organisation | Oslo University Hospital |
Country | Norway |
Sector | Hospitals |
PI Contribution | Chair the Study Group. Proposed EULAR Task Force with multiple academic and industry partners. |
Collaborator Contribution | TBD |
Impact | TBD |
Start Year | 2019 |
Description | EULAR Task Force on Therapeutic Monitoring of Biologics |
Organisation | Reade |
Country | Netherlands |
Sector | Hospitals |
PI Contribution | Chair the Study Group. Proposed EULAR Task Force with multiple academic and industry partners. |
Collaborator Contribution | TBD |
Impact | TBD |
Start Year | 2019 |
Description | EULAR Task Force on Therapeutic Monitoring of Biologics |
Organisation | Regional University Hospital of Tours |
Country | France |
Sector | Hospitals |
PI Contribution | Chair the Study Group. Proposed EULAR Task Force with multiple academic and industry partners. |
Collaborator Contribution | TBD |
Impact | TBD |
Start Year | 2019 |
Description | EULAR Task Force on Therapeutic Monitoring of Biologics |
Organisation | Sanquin |
Country | Netherlands |
Sector | Private |
PI Contribution | Chair the Study Group. Proposed EULAR Task Force with multiple academic and industry partners. |
Collaborator Contribution | TBD |
Impact | TBD |
Start Year | 2019 |
Description | EULAR Task Force on Therapeutic Monitoring of Biologics |
Organisation | St. George Hospital |
Country | India |
Sector | Hospitals |
PI Contribution | Chair the Study Group. Proposed EULAR Task Force with multiple academic and industry partners. |
Collaborator Contribution | TBD |
Impact | TBD |
Start Year | 2019 |
Description | EULAR Task Force on Therapeutic Monitoring of Biologics |
Organisation | University of Amsterdam |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Chair the Study Group. Proposed EULAR Task Force with multiple academic and industry partners. |
Collaborator Contribution | TBD |
Impact | TBD |
Start Year | 2019 |
Description | GSK |
Organisation | Addenbrooke's Hospital |
Department | Addenbrooke's Centre for Clinical Investigation (ACCI) |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Analysis of biomarkers |
Collaborator Contribution | Funding of clinical trial |
Impact | nil yet |
Start Year | 2009 |
Description | IDEA-FAST EU IMI |
Organisation | Janssen Pharmaceutica NV |
Country | Belgium |
Sector | Private |
PI Contribution | Identifying Digital Endpoints to Assess Fatigue, Sleep and Activities of Daily Living in Neurodegenerative Disorders and Immune-mediated Inflammatory Diseases. Fatigue and Wearable Devices Trials |
Collaborator Contribution | IDEA-FAST is an IMI2 consortium that aims to identify digital endpoints that provide reliable, objective and sensitive evaluation of activities of daily life (ADL), disability and health related-quality of life (HRQoL) fort he following neurodegenrative diseases (NDD): Parkinson's Disease (PD), Huntington's Disease (HD) and the following immune-mediated inflammatory diseases (IMID): Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Primary Sjögren's Syndrome (PSS), and Inflammatory Bowel Disease (IBD). |
Impact | None yet |
Start Year | 2019 |
Description | IDEA-FAST EU IMI |
Organisation | Takeda Pharmaceutical Company |
Country | Japan |
Sector | Private |
PI Contribution | Identifying Digital Endpoints to Assess Fatigue, Sleep and Activities of Daily Living in Neurodegenerative Disorders and Immune-mediated Inflammatory Diseases. Fatigue and Wearable Devices Trials |
Collaborator Contribution | IDEA-FAST is an IMI2 consortium that aims to identify digital endpoints that provide reliable, objective and sensitive evaluation of activities of daily life (ADL), disability and health related-quality of life (HRQoL) fort he following neurodegenrative diseases (NDD): Parkinson's Disease (PD), Huntington's Disease (HD) and the following immune-mediated inflammatory diseases (IMID): Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Primary Sjögren's Syndrome (PSS), and Inflammatory Bowel Disease (IBD). |
Impact | None yet |
Start Year | 2019 |
Description | IDEA-FAST EU IMI |
Organisation | University Hospital Schleswig-Holstein -Kiel |
Country | Germany |
Sector | Academic/University |
PI Contribution | Identifying Digital Endpoints to Assess Fatigue, Sleep and Activities of Daily Living in Neurodegenerative Disorders and Immune-mediated Inflammatory Diseases. Fatigue and Wearable Devices Trials |
Collaborator Contribution | IDEA-FAST is an IMI2 consortium that aims to identify digital endpoints that provide reliable, objective and sensitive evaluation of activities of daily life (ADL), disability and health related-quality of life (HRQoL) fort he following neurodegenrative diseases (NDD): Parkinson's Disease (PD), Huntington's Disease (HD) and the following immune-mediated inflammatory diseases (IMID): Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Primary Sjögren's Syndrome (PSS), and Inflammatory Bowel Disease (IBD). |
Impact | None yet |
Start Year | 2019 |
Description | IMI consortium RT-CURE |
Organisation | Apitope |
Country | Belgium |
Sector | Private |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | Bristol-Myers Squibb |
Country | United States |
Sector | Private |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | GlaxoSmithKline (GSK) |
Country | Global |
Sector | Private |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | Johnson & Johnson |
Country | United States |
Sector | Private |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | Karolinska Institute |
Country | Sweden |
Sector | Academic/University |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | Leibniz Association |
Department | German Rheumatism Research Centre |
Country | Germany |
Sector | Charity/Non Profit |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | Leiden University Medical Center |
Department | Department of Rheumatology |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | Pfizer Inc |
Country | United States |
Sector | Private |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | Royal Berkshire Hospital |
Department | Rheumatology Department |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | Sanofi |
Country | Global |
Sector | Private |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | UCB Pharma |
Country | United Kingdom |
Sector | Private |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | University Hospital Erlangen |
Department | Department of Rheumatology and Immunology |
Country | Germany |
Sector | Academic/University |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | University of Bath |
Department | Rheumatology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | University of Birmingham |
Department | Institute of Cancer and Genomic Sciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | University of Glasgow |
Department | Department of Rheumatology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMI consortium RT-CURE |
Organisation | University of Queensland |
Country | Australia |
Sector | Academic/University |
PI Contribution | As a consequence of AuToDeCRA, we have been invited to partipicate in an EU-IMI proposal for tolerance-inducing therapies in rheumatic disease. Newcastle leads WP6 , the clinical trials work package, and contributes to all other WPs. In particular we contribute cohorts to WP2, and immunology/biomarker expertise to WPs 3 and 4. AuToDeCRA 2 is partly supported by RT-CURE. Attendance at scientific meetings. Recommendations in development for regulatory discussion. |
Collaborator Contribution | Active contributions from all partners. |
Impact | The initial output will be a funding application. Monograph of Tolerising Therapies in preparation. Regulatory position statement in development. |
Start Year | 2018 |
Description | IMID-BIO-UK |
Organisation | Queen Mary University of London |
Department | William Harvey Research Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | PROVISION OF DATA AND BIOBANKED SAMPLES FROM RA-MAP |
Collaborator Contribution | PROVISION OF DATA AND BIOBANKED SAMPLES FROM MATURA, UK-PBC, Primary Sjogren's Syndrome registry |
Impact | IMID-BIO Scientific Meeting - Nov 2020 IMID-BIO Academic Datathon - Jun 2020 IMID-BIO Joint Industry Datathon - Nov 2020 |
Start Year | 2018 |
Description | IMID-BIO-UK |
Organisation | University of Cambridge |
Department | School of Clinical Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | PROVISION OF DATA AND BIOBANKED SAMPLES FROM RA-MAP |
Collaborator Contribution | PROVISION OF DATA AND BIOBANKED SAMPLES FROM MATURA, UK-PBC, Primary Sjogren's Syndrome registry |
Impact | IMID-BIO Scientific Meeting - Nov 2020 IMID-BIO Academic Datathon - Jun 2020 IMID-BIO Joint Industry Datathon - Nov 2020 |
Start Year | 2018 |
Description | IMID-BIO-UK |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | PROVISION OF DATA AND BIOBANKED SAMPLES FROM RA-MAP |
Collaborator Contribution | PROVISION OF DATA AND BIOBANKED SAMPLES FROM MATURA, UK-PBC, Primary Sjogren's Syndrome registry |
Impact | IMID-BIO Scientific Meeting - Nov 2020 IMID-BIO Academic Datathon - Jun 2020 IMID-BIO Joint Industry Datathon - Nov 2020 |
Start Year | 2018 |
Description | IMID-BIO-UK |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | PROVISION OF DATA AND BIOBANKED SAMPLES FROM RA-MAP |
Collaborator Contribution | PROVISION OF DATA AND BIOBANKED SAMPLES FROM MATURA, UK-PBC, Primary Sjogren's Syndrome registry |
Impact | IMID-BIO Scientific Meeting - Nov 2020 IMID-BIO Academic Datathon - Jun 2020 IMID-BIO Joint Industry Datathon - Nov 2020 |
Start Year | 2018 |
Description | IMID-BIO-UK Immune Mediated Inflammatory Diseases consortium |
Organisation | King's College London |
Department | School of Biomedical Sciences KCL |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contributed to strategic planning for the IMID-Bio-UK consortium and prospective grant awards. |
Collaborator Contribution | All partners manage individual consortia researching immune-mediated inflammatory diseases. All partners contributed to further funding applications. |
Impact | EU IMI 'Big Data' grant submission - unsuccessful. MRC 'Comorbidities' grant submission - second stage though unsuccessful. |
Start Year | 2018 |
Description | IMID-BIO-UK Immune Mediated Inflammatory Diseases consortium |
Organisation | Queen Mary University of London |
Department | School of Biological and Chemical Science QMUL |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contributed to strategic planning for the IMID-Bio-UK consortium and prospective grant awards. |
Collaborator Contribution | All partners manage individual consortia researching immune-mediated inflammatory diseases. All partners contributed to further funding applications. |
Impact | EU IMI 'Big Data' grant submission - unsuccessful. MRC 'Comorbidities' grant submission - second stage though unsuccessful. |
Start Year | 2018 |
Description | IMID-BIO-UK Immune Mediated Inflammatory Diseases consortium |
Organisation | University of Cambridge |
Department | Cambridge-Africa |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contributed to strategic planning for the IMID-Bio-UK consortium and prospective grant awards. |
Collaborator Contribution | All partners manage individual consortia researching immune-mediated inflammatory diseases. All partners contributed to further funding applications. |
Impact | EU IMI 'Big Data' grant submission - unsuccessful. MRC 'Comorbidities' grant submission - second stage though unsuccessful. |
Start Year | 2018 |
Description | IMID-BIO-UK Immune Mediated Inflammatory Diseases consortium |
Organisation | University of Glasgow |
Department | Mental Health Rights Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contributed to strategic planning for the IMID-Bio-UK consortium and prospective grant awards. |
Collaborator Contribution | All partners manage individual consortia researching immune-mediated inflammatory diseases. All partners contributed to further funding applications. |
Impact | EU IMI 'Big Data' grant submission - unsuccessful. MRC 'Comorbidities' grant submission - second stage though unsuccessful. |
Start Year | 2018 |
Description | IMID-BIO-UK Immune Mediated Inflammatory Diseases consortium |
Organisation | University of Manchester |
Department | Mancester Breast Centre |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contributed to strategic planning for the IMID-Bio-UK consortium and prospective grant awards. |
Collaborator Contribution | All partners manage individual consortia researching immune-mediated inflammatory diseases. All partners contributed to further funding applications. |
Impact | EU IMI 'Big Data' grant submission - unsuccessful. MRC 'Comorbidities' grant submission - second stage though unsuccessful. |
Start Year | 2018 |
Description | Joint TRC-Janssen Collaboration |
Organisation | Johnson & Johnson |
Department | Janssen Pharmaceuticals |
Country | United States |
Sector | Private |
PI Contribution | Designed and performed a specific experimental medicine research study. |
Collaborator Contribution | Designed and performed the study; analysed samples from the study. |
Impact | Plans for future collaboration. |
Start Year | 2016 |
Description | King's Health Partners (Viapath) |
Organisation | Viapath |
Country | United Kingdom |
Sector | Private |
PI Contribution | n/a |
Collaborator Contribution | Partnership with King's Health Partners (Viapath) to undertake assays for rheumatoid factor and anti-CCP antibodies, and high sensitivity CRP assays in serum from the first 300 patients recruited to the PREVeNT RA cohort of first degree relatives of patients with RA. |
Impact | None yet. |
Start Year | 2014 |
Description | MATURA consortium |
Organisation | Cardiff University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | recruitment to the STRAP trial proteomic analyses |
Collaborator Contribution | The overarching mission of the MATURA Consortium is to improve patient care in rheumatoid arthritis (RA) by rationalising therapy decisions through the use of a stratified medicines approach. Background: RA provides the ideal setting for the introduction of a stratified medicine approach because, first, the treatment is standardised in England through National Institute of Health and Clinical Excellence (NICE) guidance such that methotrexate (MTX) is the first choice disease modifying anti-rheumatic drug (DMARD); patients who fail to respond to MTX and at least one other DMARD are eligible for biologic TNF pathway blocking drugs (anti- TNFs) or, more recently IL6 pathway blocking drugs, tocilizumab (TOC), and those who fail to respond to anti-TNF can then be switched to the biologic B-cell depleting therapy, rituximab (RTX). Second, it is well established that there is a significant non - response rate to each drug (MTX (45% by 2 years), anti-TNF (25% by 6 months) and RTX (40% by 6 months). Third, the biologic drugs (anti-TNF, TOC and RTX) are expensive and all 4 drugs are associated with serious adverse events; hence, identifying those patients least likely to respond would improve the cost-benefit analysis. Finally, introduction of early, effective therapy has consistently been shown to improve long-term outcomes including joint damage, disability and employment. Aim: To identify treatment response predictors which will allow the allocation of patients to strata defined by the therapy they are most likely to respond to, early in the disease process. Methods: Two parallel workstrands (WS) will investigate synovial tissue (WS.1) and peripheral blood (WS.2) to identify biomarkers of response. Thus, in WS.1 we shall search for tissue-driven biomarkers and blood correlates in the largest synovial tissue biobank of this type (2 time points 0 & 6 months biopsy) in the world & clinical datasets (over 200 patients immediately available). In addition, in a prospective randomised clinical trial (adaptive design) we will test the hypothesis that discrete cellular and molecular signatures in the synovial tissue ("pathotypes") will enrich for response to existing biologic therapies. In WS.2, we will take advantage of the large observational cohorts of patient samples either already collected or which could be collected for minimal cost to undertake a comprehensive analysis to identify genetic, genomic, transcriptomic, proteomic or, more likely, a combination of these factors that will reliably identify responders/non-responders to each of the drugs. These collections include biological samples from over 3,000 anti-TNF-, 1,500 MTX-, 1,200 RTX- and 200 TOC-treated subjects. The two WSs are fully integrated through "multi-omic" approaches that constitute cross-cutting themes (CTs) that will converge in a large analytical and modelling package driven by experts in Bioinformatics and Statistics and allow preliminary health economic assessments of identified biomarkers. Finally, in collaboration with our Industry partners we have drawn up plans to commercialize potential diagnostics for patient benefit and wealth generation. Outcome: By the end of the study, we will have identified biomarkers of response for four of the most commonly used drugs in the treatment of RA. The study design allows a comprehensive and cohesive assault on the problem of identifying, which patients will respond best to which treatments in RA and has the potential for enormous clinical and economic impact. |
Impact | Medicine statistics bioinformatics multiple industry partners |
Start Year | 2014 |
Description | MATURA consortium |
Organisation | King's College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | recruitment to the STRAP trial proteomic analyses |
Collaborator Contribution | The overarching mission of the MATURA Consortium is to improve patient care in rheumatoid arthritis (RA) by rationalising therapy decisions through the use of a stratified medicines approach. Background: RA provides the ideal setting for the introduction of a stratified medicine approach because, first, the treatment is standardised in England through National Institute of Health and Clinical Excellence (NICE) guidance such that methotrexate (MTX) is the first choice disease modifying anti-rheumatic drug (DMARD); patients who fail to respond to MTX and at least one other DMARD are eligible for biologic TNF pathway blocking drugs (anti- TNFs) or, more recently IL6 pathway blocking drugs, tocilizumab (TOC), and those who fail to respond to anti-TNF can then be switched to the biologic B-cell depleting therapy, rituximab (RTX). Second, it is well established that there is a significant non - response rate to each drug (MTX (45% by 2 years), anti-TNF (25% by 6 months) and RTX (40% by 6 months). Third, the biologic drugs (anti-TNF, TOC and RTX) are expensive and all 4 drugs are associated with serious adverse events; hence, identifying those patients least likely to respond would improve the cost-benefit analysis. Finally, introduction of early, effective therapy has consistently been shown to improve long-term outcomes including joint damage, disability and employment. Aim: To identify treatment response predictors which will allow the allocation of patients to strata defined by the therapy they are most likely to respond to, early in the disease process. Methods: Two parallel workstrands (WS) will investigate synovial tissue (WS.1) and peripheral blood (WS.2) to identify biomarkers of response. Thus, in WS.1 we shall search for tissue-driven biomarkers and blood correlates in the largest synovial tissue biobank of this type (2 time points 0 & 6 months biopsy) in the world & clinical datasets (over 200 patients immediately available). In addition, in a prospective randomised clinical trial (adaptive design) we will test the hypothesis that discrete cellular and molecular signatures in the synovial tissue ("pathotypes") will enrich for response to existing biologic therapies. In WS.2, we will take advantage of the large observational cohorts of patient samples either already collected or which could be collected for minimal cost to undertake a comprehensive analysis to identify genetic, genomic, transcriptomic, proteomic or, more likely, a combination of these factors that will reliably identify responders/non-responders to each of the drugs. These collections include biological samples from over 3,000 anti-TNF-, 1,500 MTX-, 1,200 RTX- and 200 TOC-treated subjects. The two WSs are fully integrated through "multi-omic" approaches that constitute cross-cutting themes (CTs) that will converge in a large analytical and modelling package driven by experts in Bioinformatics and Statistics and allow preliminary health economic assessments of identified biomarkers. Finally, in collaboration with our Industry partners we have drawn up plans to commercialize potential diagnostics for patient benefit and wealth generation. Outcome: By the end of the study, we will have identified biomarkers of response for four of the most commonly used drugs in the treatment of RA. The study design allows a comprehensive and cohesive assault on the problem of identifying, which patients will respond best to which treatments in RA and has the potential for enormous clinical and economic impact. |
Impact | Medicine statistics bioinformatics multiple industry partners |
Start Year | 2014 |
Description | MATURA consortium |
Organisation | Queen Mary University of London |
Department | William Harvey Research Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | recruitment to the STRAP trial proteomic analyses |
Collaborator Contribution | The overarching mission of the MATURA Consortium is to improve patient care in rheumatoid arthritis (RA) by rationalising therapy decisions through the use of a stratified medicines approach. Background: RA provides the ideal setting for the introduction of a stratified medicine approach because, first, the treatment is standardised in England through National Institute of Health and Clinical Excellence (NICE) guidance such that methotrexate (MTX) is the first choice disease modifying anti-rheumatic drug (DMARD); patients who fail to respond to MTX and at least one other DMARD are eligible for biologic TNF pathway blocking drugs (anti- TNFs) or, more recently IL6 pathway blocking drugs, tocilizumab (TOC), and those who fail to respond to anti-TNF can then be switched to the biologic B-cell depleting therapy, rituximab (RTX). Second, it is well established that there is a significant non - response rate to each drug (MTX (45% by 2 years), anti-TNF (25% by 6 months) and RTX (40% by 6 months). Third, the biologic drugs (anti-TNF, TOC and RTX) are expensive and all 4 drugs are associated with serious adverse events; hence, identifying those patients least likely to respond would improve the cost-benefit analysis. Finally, introduction of early, effective therapy has consistently been shown to improve long-term outcomes including joint damage, disability and employment. Aim: To identify treatment response predictors which will allow the allocation of patients to strata defined by the therapy they are most likely to respond to, early in the disease process. Methods: Two parallel workstrands (WS) will investigate synovial tissue (WS.1) and peripheral blood (WS.2) to identify biomarkers of response. Thus, in WS.1 we shall search for tissue-driven biomarkers and blood correlates in the largest synovial tissue biobank of this type (2 time points 0 & 6 months biopsy) in the world & clinical datasets (over 200 patients immediately available). In addition, in a prospective randomised clinical trial (adaptive design) we will test the hypothesis that discrete cellular and molecular signatures in the synovial tissue ("pathotypes") will enrich for response to existing biologic therapies. In WS.2, we will take advantage of the large observational cohorts of patient samples either already collected or which could be collected for minimal cost to undertake a comprehensive analysis to identify genetic, genomic, transcriptomic, proteomic or, more likely, a combination of these factors that will reliably identify responders/non-responders to each of the drugs. These collections include biological samples from over 3,000 anti-TNF-, 1,500 MTX-, 1,200 RTX- and 200 TOC-treated subjects. The two WSs are fully integrated through "multi-omic" approaches that constitute cross-cutting themes (CTs) that will converge in a large analytical and modelling package driven by experts in Bioinformatics and Statistics and allow preliminary health economic assessments of identified biomarkers. Finally, in collaboration with our Industry partners we have drawn up plans to commercialize potential diagnostics for patient benefit and wealth generation. Outcome: By the end of the study, we will have identified biomarkers of response for four of the most commonly used drugs in the treatment of RA. The study design allows a comprehensive and cohesive assault on the problem of identifying, which patients will respond best to which treatments in RA and has the potential for enormous clinical and economic impact. |
Impact | Medicine statistics bioinformatics multiple industry partners |
Start Year | 2014 |
Description | MATURA consortium |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | recruitment to the STRAP trial proteomic analyses |
Collaborator Contribution | The overarching mission of the MATURA Consortium is to improve patient care in rheumatoid arthritis (RA) by rationalising therapy decisions through the use of a stratified medicines approach. Background: RA provides the ideal setting for the introduction of a stratified medicine approach because, first, the treatment is standardised in England through National Institute of Health and Clinical Excellence (NICE) guidance such that methotrexate (MTX) is the first choice disease modifying anti-rheumatic drug (DMARD); patients who fail to respond to MTX and at least one other DMARD are eligible for biologic TNF pathway blocking drugs (anti- TNFs) or, more recently IL6 pathway blocking drugs, tocilizumab (TOC), and those who fail to respond to anti-TNF can then be switched to the biologic B-cell depleting therapy, rituximab (RTX). Second, it is well established that there is a significant non - response rate to each drug (MTX (45% by 2 years), anti-TNF (25% by 6 months) and RTX (40% by 6 months). Third, the biologic drugs (anti-TNF, TOC and RTX) are expensive and all 4 drugs are associated with serious adverse events; hence, identifying those patients least likely to respond would improve the cost-benefit analysis. Finally, introduction of early, effective therapy has consistently been shown to improve long-term outcomes including joint damage, disability and employment. Aim: To identify treatment response predictors which will allow the allocation of patients to strata defined by the therapy they are most likely to respond to, early in the disease process. Methods: Two parallel workstrands (WS) will investigate synovial tissue (WS.1) and peripheral blood (WS.2) to identify biomarkers of response. Thus, in WS.1 we shall search for tissue-driven biomarkers and blood correlates in the largest synovial tissue biobank of this type (2 time points 0 & 6 months biopsy) in the world & clinical datasets (over 200 patients immediately available). In addition, in a prospective randomised clinical trial (adaptive design) we will test the hypothesis that discrete cellular and molecular signatures in the synovial tissue ("pathotypes") will enrich for response to existing biologic therapies. In WS.2, we will take advantage of the large observational cohorts of patient samples either already collected or which could be collected for minimal cost to undertake a comprehensive analysis to identify genetic, genomic, transcriptomic, proteomic or, more likely, a combination of these factors that will reliably identify responders/non-responders to each of the drugs. These collections include biological samples from over 3,000 anti-TNF-, 1,500 MTX-, 1,200 RTX- and 200 TOC-treated subjects. The two WSs are fully integrated through "multi-omic" approaches that constitute cross-cutting themes (CTs) that will converge in a large analytical and modelling package driven by experts in Bioinformatics and Statistics and allow preliminary health economic assessments of identified biomarkers. Finally, in collaboration with our Industry partners we have drawn up plans to commercialize potential diagnostics for patient benefit and wealth generation. Outcome: By the end of the study, we will have identified biomarkers of response for four of the most commonly used drugs in the treatment of RA. The study design allows a comprehensive and cohesive assault on the problem of identifying, which patients will respond best to which treatments in RA and has the potential for enormous clinical and economic impact. |
Impact | Medicine statistics bioinformatics multiple industry partners |
Start Year | 2014 |
Description | MATURA consortium |
Organisation | University of Birmingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | recruitment to the STRAP trial proteomic analyses |
Collaborator Contribution | The overarching mission of the MATURA Consortium is to improve patient care in rheumatoid arthritis (RA) by rationalising therapy decisions through the use of a stratified medicines approach. Background: RA provides the ideal setting for the introduction of a stratified medicine approach because, first, the treatment is standardised in England through National Institute of Health and Clinical Excellence (NICE) guidance such that methotrexate (MTX) is the first choice disease modifying anti-rheumatic drug (DMARD); patients who fail to respond to MTX and at least one other DMARD are eligible for biologic TNF pathway blocking drugs (anti- TNFs) or, more recently IL6 pathway blocking drugs, tocilizumab (TOC), and those who fail to respond to anti-TNF can then be switched to the biologic B-cell depleting therapy, rituximab (RTX). Second, it is well established that there is a significant non - response rate to each drug (MTX (45% by 2 years), anti-TNF (25% by 6 months) and RTX (40% by 6 months). Third, the biologic drugs (anti-TNF, TOC and RTX) are expensive and all 4 drugs are associated with serious adverse events; hence, identifying those patients least likely to respond would improve the cost-benefit analysis. Finally, introduction of early, effective therapy has consistently been shown to improve long-term outcomes including joint damage, disability and employment. Aim: To identify treatment response predictors which will allow the allocation of patients to strata defined by the therapy they are most likely to respond to, early in the disease process. Methods: Two parallel workstrands (WS) will investigate synovial tissue (WS.1) and peripheral blood (WS.2) to identify biomarkers of response. Thus, in WS.1 we shall search for tissue-driven biomarkers and blood correlates in the largest synovial tissue biobank of this type (2 time points 0 & 6 months biopsy) in the world & clinical datasets (over 200 patients immediately available). In addition, in a prospective randomised clinical trial (adaptive design) we will test the hypothesis that discrete cellular and molecular signatures in the synovial tissue ("pathotypes") will enrich for response to existing biologic therapies. In WS.2, we will take advantage of the large observational cohorts of patient samples either already collected or which could be collected for minimal cost to undertake a comprehensive analysis to identify genetic, genomic, transcriptomic, proteomic or, more likely, a combination of these factors that will reliably identify responders/non-responders to each of the drugs. These collections include biological samples from over 3,000 anti-TNF-, 1,500 MTX-, 1,200 RTX- and 200 TOC-treated subjects. The two WSs are fully integrated through "multi-omic" approaches that constitute cross-cutting themes (CTs) that will converge in a large analytical and modelling package driven by experts in Bioinformatics and Statistics and allow preliminary health economic assessments of identified biomarkers. Finally, in collaboration with our Industry partners we have drawn up plans to commercialize potential diagnostics for patient benefit and wealth generation. Outcome: By the end of the study, we will have identified biomarkers of response for four of the most commonly used drugs in the treatment of RA. The study design allows a comprehensive and cohesive assault on the problem of identifying, which patients will respond best to which treatments in RA and has the potential for enormous clinical and economic impact. |
Impact | Medicine statistics bioinformatics multiple industry partners |
Start Year | 2014 |
Description | MATURA consortium |
Organisation | University of Edinburgh |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | recruitment to the STRAP trial proteomic analyses |
Collaborator Contribution | The overarching mission of the MATURA Consortium is to improve patient care in rheumatoid arthritis (RA) by rationalising therapy decisions through the use of a stratified medicines approach. Background: RA provides the ideal setting for the introduction of a stratified medicine approach because, first, the treatment is standardised in England through National Institute of Health and Clinical Excellence (NICE) guidance such that methotrexate (MTX) is the first choice disease modifying anti-rheumatic drug (DMARD); patients who fail to respond to MTX and at least one other DMARD are eligible for biologic TNF pathway blocking drugs (anti- TNFs) or, more recently IL6 pathway blocking drugs, tocilizumab (TOC), and those who fail to respond to anti-TNF can then be switched to the biologic B-cell depleting therapy, rituximab (RTX). Second, it is well established that there is a significant non - response rate to each drug (MTX (45% by 2 years), anti-TNF (25% by 6 months) and RTX (40% by 6 months). Third, the biologic drugs (anti-TNF, TOC and RTX) are expensive and all 4 drugs are associated with serious adverse events; hence, identifying those patients least likely to respond would improve the cost-benefit analysis. Finally, introduction of early, effective therapy has consistently been shown to improve long-term outcomes including joint damage, disability and employment. Aim: To identify treatment response predictors which will allow the allocation of patients to strata defined by the therapy they are most likely to respond to, early in the disease process. Methods: Two parallel workstrands (WS) will investigate synovial tissue (WS.1) and peripheral blood (WS.2) to identify biomarkers of response. Thus, in WS.1 we shall search for tissue-driven biomarkers and blood correlates in the largest synovial tissue biobank of this type (2 time points 0 & 6 months biopsy) in the world & clinical datasets (over 200 patients immediately available). In addition, in a prospective randomised clinical trial (adaptive design) we will test the hypothesis that discrete cellular and molecular signatures in the synovial tissue ("pathotypes") will enrich for response to existing biologic therapies. In WS.2, we will take advantage of the large observational cohorts of patient samples either already collected or which could be collected for minimal cost to undertake a comprehensive analysis to identify genetic, genomic, transcriptomic, proteomic or, more likely, a combination of these factors that will reliably identify responders/non-responders to each of the drugs. These collections include biological samples from over 3,000 anti-TNF-, 1,500 MTX-, 1,200 RTX- and 200 TOC-treated subjects. The two WSs are fully integrated through "multi-omic" approaches that constitute cross-cutting themes (CTs) that will converge in a large analytical and modelling package driven by experts in Bioinformatics and Statistics and allow preliminary health economic assessments of identified biomarkers. Finally, in collaboration with our Industry partners we have drawn up plans to commercialize potential diagnostics for patient benefit and wealth generation. Outcome: By the end of the study, we will have identified biomarkers of response for four of the most commonly used drugs in the treatment of RA. The study design allows a comprehensive and cohesive assault on the problem of identifying, which patients will respond best to which treatments in RA and has the potential for enormous clinical and economic impact. |
Impact | Medicine statistics bioinformatics multiple industry partners |
Start Year | 2014 |
Description | MATURA consortium |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | recruitment to the STRAP trial proteomic analyses |
Collaborator Contribution | The overarching mission of the MATURA Consortium is to improve patient care in rheumatoid arthritis (RA) by rationalising therapy decisions through the use of a stratified medicines approach. Background: RA provides the ideal setting for the introduction of a stratified medicine approach because, first, the treatment is standardised in England through National Institute of Health and Clinical Excellence (NICE) guidance such that methotrexate (MTX) is the first choice disease modifying anti-rheumatic drug (DMARD); patients who fail to respond to MTX and at least one other DMARD are eligible for biologic TNF pathway blocking drugs (anti- TNFs) or, more recently IL6 pathway blocking drugs, tocilizumab (TOC), and those who fail to respond to anti-TNF can then be switched to the biologic B-cell depleting therapy, rituximab (RTX). Second, it is well established that there is a significant non - response rate to each drug (MTX (45% by 2 years), anti-TNF (25% by 6 months) and RTX (40% by 6 months). Third, the biologic drugs (anti-TNF, TOC and RTX) are expensive and all 4 drugs are associated with serious adverse events; hence, identifying those patients least likely to respond would improve the cost-benefit analysis. Finally, introduction of early, effective therapy has consistently been shown to improve long-term outcomes including joint damage, disability and employment. Aim: To identify treatment response predictors which will allow the allocation of patients to strata defined by the therapy they are most likely to respond to, early in the disease process. Methods: Two parallel workstrands (WS) will investigate synovial tissue (WS.1) and peripheral blood (WS.2) to identify biomarkers of response. Thus, in WS.1 we shall search for tissue-driven biomarkers and blood correlates in the largest synovial tissue biobank of this type (2 time points 0 & 6 months biopsy) in the world & clinical datasets (over 200 patients immediately available). In addition, in a prospective randomised clinical trial (adaptive design) we will test the hypothesis that discrete cellular and molecular signatures in the synovial tissue ("pathotypes") will enrich for response to existing biologic therapies. In WS.2, we will take advantage of the large observational cohorts of patient samples either already collected or which could be collected for minimal cost to undertake a comprehensive analysis to identify genetic, genomic, transcriptomic, proteomic or, more likely, a combination of these factors that will reliably identify responders/non-responders to each of the drugs. These collections include biological samples from over 3,000 anti-TNF-, 1,500 MTX-, 1,200 RTX- and 200 TOC-treated subjects. The two WSs are fully integrated through "multi-omic" approaches that constitute cross-cutting themes (CTs) that will converge in a large analytical and modelling package driven by experts in Bioinformatics and Statistics and allow preliminary health economic assessments of identified biomarkers. Finally, in collaboration with our Industry partners we have drawn up plans to commercialize potential diagnostics for patient benefit and wealth generation. Outcome: By the end of the study, we will have identified biomarkers of response for four of the most commonly used drugs in the treatment of RA. The study design allows a comprehensive and cohesive assault on the problem of identifying, which patients will respond best to which treatments in RA and has the potential for enormous clinical and economic impact. |
Impact | Medicine statistics bioinformatics multiple industry partners |
Start Year | 2014 |
Description | MATURA consortium |
Organisation | University of Hertfordshire |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | recruitment to the STRAP trial proteomic analyses |
Collaborator Contribution | The overarching mission of the MATURA Consortium is to improve patient care in rheumatoid arthritis (RA) by rationalising therapy decisions through the use of a stratified medicines approach. Background: RA provides the ideal setting for the introduction of a stratified medicine approach because, first, the treatment is standardised in England through National Institute of Health and Clinical Excellence (NICE) guidance such that methotrexate (MTX) is the first choice disease modifying anti-rheumatic drug (DMARD); patients who fail to respond to MTX and at least one other DMARD are eligible for biologic TNF pathway blocking drugs (anti- TNFs) or, more recently IL6 pathway blocking drugs, tocilizumab (TOC), and those who fail to respond to anti-TNF can then be switched to the biologic B-cell depleting therapy, rituximab (RTX). Second, it is well established that there is a significant non - response rate to each drug (MTX (45% by 2 years), anti-TNF (25% by 6 months) and RTX (40% by 6 months). Third, the biologic drugs (anti-TNF, TOC and RTX) are expensive and all 4 drugs are associated with serious adverse events; hence, identifying those patients least likely to respond would improve the cost-benefit analysis. Finally, introduction of early, effective therapy has consistently been shown to improve long-term outcomes including joint damage, disability and employment. Aim: To identify treatment response predictors which will allow the allocation of patients to strata defined by the therapy they are most likely to respond to, early in the disease process. Methods: Two parallel workstrands (WS) will investigate synovial tissue (WS.1) and peripheral blood (WS.2) to identify biomarkers of response. Thus, in WS.1 we shall search for tissue-driven biomarkers and blood correlates in the largest synovial tissue biobank of this type (2 time points 0 & 6 months biopsy) in the world & clinical datasets (over 200 patients immediately available). In addition, in a prospective randomised clinical trial (adaptive design) we will test the hypothesis that discrete cellular and molecular signatures in the synovial tissue ("pathotypes") will enrich for response to existing biologic therapies. In WS.2, we will take advantage of the large observational cohorts of patient samples either already collected or which could be collected for minimal cost to undertake a comprehensive analysis to identify genetic, genomic, transcriptomic, proteomic or, more likely, a combination of these factors that will reliably identify responders/non-responders to each of the drugs. These collections include biological samples from over 3,000 anti-TNF-, 1,500 MTX-, 1,200 RTX- and 200 TOC-treated subjects. The two WSs are fully integrated through "multi-omic" approaches that constitute cross-cutting themes (CTs) that will converge in a large analytical and modelling package driven by experts in Bioinformatics and Statistics and allow preliminary health economic assessments of identified biomarkers. Finally, in collaboration with our Industry partners we have drawn up plans to commercialize potential diagnostics for patient benefit and wealth generation. Outcome: By the end of the study, we will have identified biomarkers of response for four of the most commonly used drugs in the treatment of RA. The study design allows a comprehensive and cohesive assault on the problem of identifying, which patients will respond best to which treatments in RA and has the potential for enormous clinical and economic impact. |
Impact | Medicine statistics bioinformatics multiple industry partners |
Start Year | 2014 |
Description | MATURA consortium |
Organisation | University of Leeds |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | recruitment to the STRAP trial proteomic analyses |
Collaborator Contribution | The overarching mission of the MATURA Consortium is to improve patient care in rheumatoid arthritis (RA) by rationalising therapy decisions through the use of a stratified medicines approach. Background: RA provides the ideal setting for the introduction of a stratified medicine approach because, first, the treatment is standardised in England through National Institute of Health and Clinical Excellence (NICE) guidance such that methotrexate (MTX) is the first choice disease modifying anti-rheumatic drug (DMARD); patients who fail to respond to MTX and at least one other DMARD are eligible for biologic TNF pathway blocking drugs (anti- TNFs) or, more recently IL6 pathway blocking drugs, tocilizumab (TOC), and those who fail to respond to anti-TNF can then be switched to the biologic B-cell depleting therapy, rituximab (RTX). Second, it is well established that there is a significant non - response rate to each drug (MTX (45% by 2 years), anti-TNF (25% by 6 months) and RTX (40% by 6 months). Third, the biologic drugs (anti-TNF, TOC and RTX) are expensive and all 4 drugs are associated with serious adverse events; hence, identifying those patients least likely to respond would improve the cost-benefit analysis. Finally, introduction of early, effective therapy has consistently been shown to improve long-term outcomes including joint damage, disability and employment. Aim: To identify treatment response predictors which will allow the allocation of patients to strata defined by the therapy they are most likely to respond to, early in the disease process. Methods: Two parallel workstrands (WS) will investigate synovial tissue (WS.1) and peripheral blood (WS.2) to identify biomarkers of response. Thus, in WS.1 we shall search for tissue-driven biomarkers and blood correlates in the largest synovial tissue biobank of this type (2 time points 0 & 6 months biopsy) in the world & clinical datasets (over 200 patients immediately available). In addition, in a prospective randomised clinical trial (adaptive design) we will test the hypothesis that discrete cellular and molecular signatures in the synovial tissue ("pathotypes") will enrich for response to existing biologic therapies. In WS.2, we will take advantage of the large observational cohorts of patient samples either already collected or which could be collected for minimal cost to undertake a comprehensive analysis to identify genetic, genomic, transcriptomic, proteomic or, more likely, a combination of these factors that will reliably identify responders/non-responders to each of the drugs. These collections include biological samples from over 3,000 anti-TNF-, 1,500 MTX-, 1,200 RTX- and 200 TOC-treated subjects. The two WSs are fully integrated through "multi-omic" approaches that constitute cross-cutting themes (CTs) that will converge in a large analytical and modelling package driven by experts in Bioinformatics and Statistics and allow preliminary health economic assessments of identified biomarkers. Finally, in collaboration with our Industry partners we have drawn up plans to commercialize potential diagnostics for patient benefit and wealth generation. Outcome: By the end of the study, we will have identified biomarkers of response for four of the most commonly used drugs in the treatment of RA. The study design allows a comprehensive and cohesive assault on the problem of identifying, which patients will respond best to which treatments in RA and has the potential for enormous clinical and economic impact. |
Impact | Medicine statistics bioinformatics multiple industry partners |
Start Year | 2014 |
Description | MATURA consortium |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | recruitment to the STRAP trial proteomic analyses |
Collaborator Contribution | The overarching mission of the MATURA Consortium is to improve patient care in rheumatoid arthritis (RA) by rationalising therapy decisions through the use of a stratified medicines approach. Background: RA provides the ideal setting for the introduction of a stratified medicine approach because, first, the treatment is standardised in England through National Institute of Health and Clinical Excellence (NICE) guidance such that methotrexate (MTX) is the first choice disease modifying anti-rheumatic drug (DMARD); patients who fail to respond to MTX and at least one other DMARD are eligible for biologic TNF pathway blocking drugs (anti- TNFs) or, more recently IL6 pathway blocking drugs, tocilizumab (TOC), and those who fail to respond to anti-TNF can then be switched to the biologic B-cell depleting therapy, rituximab (RTX). Second, it is well established that there is a significant non - response rate to each drug (MTX (45% by 2 years), anti-TNF (25% by 6 months) and RTX (40% by 6 months). Third, the biologic drugs (anti-TNF, TOC and RTX) are expensive and all 4 drugs are associated with serious adverse events; hence, identifying those patients least likely to respond would improve the cost-benefit analysis. Finally, introduction of early, effective therapy has consistently been shown to improve long-term outcomes including joint damage, disability and employment. Aim: To identify treatment response predictors which will allow the allocation of patients to strata defined by the therapy they are most likely to respond to, early in the disease process. Methods: Two parallel workstrands (WS) will investigate synovial tissue (WS.1) and peripheral blood (WS.2) to identify biomarkers of response. Thus, in WS.1 we shall search for tissue-driven biomarkers and blood correlates in the largest synovial tissue biobank of this type (2 time points 0 & 6 months biopsy) in the world & clinical datasets (over 200 patients immediately available). In addition, in a prospective randomised clinical trial (adaptive design) we will test the hypothesis that discrete cellular and molecular signatures in the synovial tissue ("pathotypes") will enrich for response to existing biologic therapies. In WS.2, we will take advantage of the large observational cohorts of patient samples either already collected or which could be collected for minimal cost to undertake a comprehensive analysis to identify genetic, genomic, transcriptomic, proteomic or, more likely, a combination of these factors that will reliably identify responders/non-responders to each of the drugs. These collections include biological samples from over 3,000 anti-TNF-, 1,500 MTX-, 1,200 RTX- and 200 TOC-treated subjects. The two WSs are fully integrated through "multi-omic" approaches that constitute cross-cutting themes (CTs) that will converge in a large analytical and modelling package driven by experts in Bioinformatics and Statistics and allow preliminary health economic assessments of identified biomarkers. Finally, in collaboration with our Industry partners we have drawn up plans to commercialize potential diagnostics for patient benefit and wealth generation. Outcome: By the end of the study, we will have identified biomarkers of response for four of the most commonly used drugs in the treatment of RA. The study design allows a comprehensive and cohesive assault on the problem of identifying, which patients will respond best to which treatments in RA and has the potential for enormous clinical and economic impact. |
Impact | Medicine statistics bioinformatics multiple industry partners |
Start Year | 2014 |
Description | MATURA consortium |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | recruitment to the STRAP trial proteomic analyses |
Collaborator Contribution | The overarching mission of the MATURA Consortium is to improve patient care in rheumatoid arthritis (RA) by rationalising therapy decisions through the use of a stratified medicines approach. Background: RA provides the ideal setting for the introduction of a stratified medicine approach because, first, the treatment is standardised in England through National Institute of Health and Clinical Excellence (NICE) guidance such that methotrexate (MTX) is the first choice disease modifying anti-rheumatic drug (DMARD); patients who fail to respond to MTX and at least one other DMARD are eligible for biologic TNF pathway blocking drugs (anti- TNFs) or, more recently IL6 pathway blocking drugs, tocilizumab (TOC), and those who fail to respond to anti-TNF can then be switched to the biologic B-cell depleting therapy, rituximab (RTX). Second, it is well established that there is a significant non - response rate to each drug (MTX (45% by 2 years), anti-TNF (25% by 6 months) and RTX (40% by 6 months). Third, the biologic drugs (anti-TNF, TOC and RTX) are expensive and all 4 drugs are associated with serious adverse events; hence, identifying those patients least likely to respond would improve the cost-benefit analysis. Finally, introduction of early, effective therapy has consistently been shown to improve long-term outcomes including joint damage, disability and employment. Aim: To identify treatment response predictors which will allow the allocation of patients to strata defined by the therapy they are most likely to respond to, early in the disease process. Methods: Two parallel workstrands (WS) will investigate synovial tissue (WS.1) and peripheral blood (WS.2) to identify biomarkers of response. Thus, in WS.1 we shall search for tissue-driven biomarkers and blood correlates in the largest synovial tissue biobank of this type (2 time points 0 & 6 months biopsy) in the world & clinical datasets (over 200 patients immediately available). In addition, in a prospective randomised clinical trial (adaptive design) we will test the hypothesis that discrete cellular and molecular signatures in the synovial tissue ("pathotypes") will enrich for response to existing biologic therapies. In WS.2, we will take advantage of the large observational cohorts of patient samples either already collected or which could be collected for minimal cost to undertake a comprehensive analysis to identify genetic, genomic, transcriptomic, proteomic or, more likely, a combination of these factors that will reliably identify responders/non-responders to each of the drugs. These collections include biological samples from over 3,000 anti-TNF-, 1,500 MTX-, 1,200 RTX- and 200 TOC-treated subjects. The two WSs are fully integrated through "multi-omic" approaches that constitute cross-cutting themes (CTs) that will converge in a large analytical and modelling package driven by experts in Bioinformatics and Statistics and allow preliminary health economic assessments of identified biomarkers. Finally, in collaboration with our Industry partners we have drawn up plans to commercialize potential diagnostics for patient benefit and wealth generation. Outcome: By the end of the study, we will have identified biomarkers of response for four of the most commonly used drugs in the treatment of RA. The study design allows a comprehensive and cohesive assault on the problem of identifying, which patients will respond best to which treatments in RA and has the potential for enormous clinical and economic impact. |
Impact | Medicine statistics bioinformatics multiple industry partners |
Start Year | 2014 |
Description | MATURA consortium |
Organisation | University of Sheffield |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | recruitment to the STRAP trial proteomic analyses |
Collaborator Contribution | The overarching mission of the MATURA Consortium is to improve patient care in rheumatoid arthritis (RA) by rationalising therapy decisions through the use of a stratified medicines approach. Background: RA provides the ideal setting for the introduction of a stratified medicine approach because, first, the treatment is standardised in England through National Institute of Health and Clinical Excellence (NICE) guidance such that methotrexate (MTX) is the first choice disease modifying anti-rheumatic drug (DMARD); patients who fail to respond to MTX and at least one other DMARD are eligible for biologic TNF pathway blocking drugs (anti- TNFs) or, more recently IL6 pathway blocking drugs, tocilizumab (TOC), and those who fail to respond to anti-TNF can then be switched to the biologic B-cell depleting therapy, rituximab (RTX). Second, it is well established that there is a significant non - response rate to each drug (MTX (45% by 2 years), anti-TNF (25% by 6 months) and RTX (40% by 6 months). Third, the biologic drugs (anti-TNF, TOC and RTX) are expensive and all 4 drugs are associated with serious adverse events; hence, identifying those patients least likely to respond would improve the cost-benefit analysis. Finally, introduction of early, effective therapy has consistently been shown to improve long-term outcomes including joint damage, disability and employment. Aim: To identify treatment response predictors which will allow the allocation of patients to strata defined by the therapy they are most likely to respond to, early in the disease process. Methods: Two parallel workstrands (WS) will investigate synovial tissue (WS.1) and peripheral blood (WS.2) to identify biomarkers of response. Thus, in WS.1 we shall search for tissue-driven biomarkers and blood correlates in the largest synovial tissue biobank of this type (2 time points 0 & 6 months biopsy) in the world & clinical datasets (over 200 patients immediately available). In addition, in a prospective randomised clinical trial (adaptive design) we will test the hypothesis that discrete cellular and molecular signatures in the synovial tissue ("pathotypes") will enrich for response to existing biologic therapies. In WS.2, we will take advantage of the large observational cohorts of patient samples either already collected or which could be collected for minimal cost to undertake a comprehensive analysis to identify genetic, genomic, transcriptomic, proteomic or, more likely, a combination of these factors that will reliably identify responders/non-responders to each of the drugs. These collections include biological samples from over 3,000 anti-TNF-, 1,500 MTX-, 1,200 RTX- and 200 TOC-treated subjects. The two WSs are fully integrated through "multi-omic" approaches that constitute cross-cutting themes (CTs) that will converge in a large analytical and modelling package driven by experts in Bioinformatics and Statistics and allow preliminary health economic assessments of identified biomarkers. Finally, in collaboration with our Industry partners we have drawn up plans to commercialize potential diagnostics for patient benefit and wealth generation. Outcome: By the end of the study, we will have identified biomarkers of response for four of the most commonly used drugs in the treatment of RA. The study design allows a comprehensive and cohesive assault on the problem of identifying, which patients will respond best to which treatments in RA and has the potential for enormous clinical and economic impact. |
Impact | Medicine statistics bioinformatics multiple industry partners |
Start Year | 2014 |
Description | MRC ABPI RA MAP Project |
Organisation | King's College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I am the UK Chief Investigator on the PREVeNT RA work stream in this MRC ABPI Award |
Collaborator Contribution | There are 6 core centres involved in this collaboration and in Manchester we lead on several of the Epidemiology Projects |
Impact | Studies are underway and early papers to follow |
Start Year | 2011 |
Description | MRC ABPI RA MAP Project |
Organisation | Newcastle University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I am the UK Chief Investigator on the PREVeNT RA work stream in this MRC ABPI Award |
Collaborator Contribution | There are 6 core centres involved in this collaboration and in Manchester we lead on several of the Epidemiology Projects |
Impact | Studies are underway and early papers to follow |
Start Year | 2011 |
Description | NIHR BioResource Steering Group |
Organisation | National Institute for Health Research |
Country | United Kingdom |
Sector | Public |
PI Contribution | Reviewing of applications to use the NIHR Bioresource Strategy development wrt to the NIHR Bioresource |
Collaborator Contribution | Reviewing of applications to use the NIHR Bioresource Strategy development wrt to the NIHR Bioresource |
Impact | Multiple studies have been supported by the NIHR Bioresource. |
Start Year | 2019 |
Description | NIHR IMID BioResource |
Organisation | University of Leeds |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Coordination and Collection of bioresource samples from regional IMID clinics |
Collaborator Contribution | Coordination and Collection of bioresource samples from regional IMID clinics |
Impact | Meetings leading to the IMID BioResource Launch Event - Jan 2021 |
Start Year | 2019 |
Description | NIHR IMID BioResource |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Coordination and Collection of bioresource samples from regional IMID clinics |
Collaborator Contribution | Coordination and Collection of bioresource samples from regional IMID clinics |
Impact | Meetings leading to the IMID BioResource Launch Event - Jan 2021 |
Start Year | 2019 |
Description | Partnership between University of Birmingham and Protagen |
Organisation | Protagen AG |
Country | Germany |
Sector | Private |
PI Contribution | Partnership between UoB and Protagen to look at autoantibody profiles in arthritis associated with anti-PD1 therapy. This arose in part through contacts made at RA-MAP. Transfer of samples governed by MTA. |
Collaborator Contribution | Partnership between UoB and Protagen to look at autoantibody profiles in arthritis associated with anti-PD1 therapy. This arose in part through contacts made at RA-MAP. Transfer of samples governed by MTA. |
Impact | None yet (autoantibody profiling in arthritis patients associated with anti-PD1 therapy) |
Start Year | 2016 |
Description | Protagen joins as a new RA-MAP partner |
Organisation | Protagen AG |
Country | Germany |
Sector | Private |
PI Contribution | Serum samples from early RA cohort (TACERA study, n=275) together with healthy controls (from Vaccine Study, n=50) will be provided to Protagen for autoantibody profiling by Protagen's SeroTag® platform. |
Collaborator Contribution | Protagen has examined autoantibodies to over 7,000 human proteins in the serum samples provided by the RA-MAP consortium. Protagen AG provided the technological platform, ran the analytical lab work, the statistical analysis and covered its own operational costs. |
Impact | None yet. |
Start Year | 2015 |
Description | RA-MAP Consortium |
Organisation | Abbott |
Department | Abbott UK |
Country | United Kingdom |
Sector | Private |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | Amgen Inc |
Country | United States |
Sector | Private |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | AstraZeneca |
Department | MedImmune |
Country | United Kingdom |
Sector | Private |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | AstraZeneca |
Country | United Kingdom |
Sector | Private |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | Bristol-Myers Squibb |
Country | United States |
Sector | Private |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | European Translational Information and Knowledge Management Services (eTRIKS) |
Country | European Union (EU) |
Sector | Charity/Non Profit |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | F. Hoffmann-La Roche AG |
Country | Global |
Sector | Private |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | GlaxoSmithKline (GSK) |
Country | Global |
Sector | Private |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | Johnson & Johnson |
Department | Janssen Pharmaceuticals |
Country | United States |
Sector | Private |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | King's College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | Pfizer Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | Queen Mary University of London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | UCB Pharma |
Country | United Kingdom |
Sector | Private |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | University of Birmingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | University of Cambridge |
Department | MRC Biostatistics Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | University of Leeds |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RA-MAP Consortium |
Organisation | University of Oxford |
Department | Kennedy Institute of Rheumatology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The collaboration is led and coordinated by Newcastle University. There are 2 Work Packages. Newcastle University lead and contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples. Newcastle University contribute to WP1, by recruiting early RA patients to the TACERA study. To eTRIKs the provision of clinically curated "omics" datasets to drive the development of a common KM platform to store data and allow the comparative analysis of clinical data |
Collaborator Contribution | 7 Academic partners contribute to WP2, "the development of an immunological toolkit" which is based on the development of assays and the identification of biomarkers from early RA clinical samples and will also contribute to WP1, by recruiting early RA patients to the TACERA study. * MRC Biostatistics Unit have provided SAPs for each of the studies *KCL lead the TACERA study *Glasgow lead the Vaccine Substudy on healthy vaccinees *Manchester lead PREVEnTRA to establish a cohort of First Degree Relatives of RA patients *Manchester University lead and coordinate the collation of RCT patient level data to identify Predictors of Remission. *Industry partners provide "in kind" support for 1. Study Operations and Coordination 2. Bioinformatics, statistics and data analysis expertise 3. Data analysis platforms and knowledge management In particular a Consortium of industrial partners (eTRIKs) have provided secure data storage via access to a KM platform (Transmart). Expertise in Knowledge Management. Namely provision of specialist expertise i) to develop the database to accept data types from various technology platforms and ii) to link data storage to specific analysis software Expertise as In kind contributions from company partners has been valued at £111,082 with personnel rates based on full loaded costings. This amounts to ~12.7% of the value of the MRC grant awarded to cover project work in the first year. |
Impact | N/A Too early in project to report outputs |
Start Year | 2012 |
Description | RACE 2 |
Organisation | University of Birmingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contribute to joint scientific efforts, as well as leading experimental medicine studies such as TRAFIC, BIO-FLARE and AuToDeCRA 2. |
Collaborator Contribution | Multiple collaborative scientific studies and grants. |
Impact | TBD |
Start Year | 2019 |
Description | RACE 2 |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contribute to joint scientific efforts, as well as leading experimental medicine studies such as TRAFIC, BIO-FLARE and AuToDeCRA 2. |
Collaborator Contribution | Multiple collaborative scientific studies and grants. |
Impact | TBD |
Start Year | 2019 |
Description | RACE 2 |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contribute to joint scientific efforts, as well as leading experimental medicine studies such as TRAFIC, BIO-FLARE and AuToDeCRA 2. |
Collaborator Contribution | Multiple collaborative scientific studies and grants. |
Impact | TBD |
Start Year | 2019 |
Description | RACE-2 Scientific Meeting, Glasgow |
Organisation | University of Birmingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | RACE is a four-partner academic consortium focussed on inflammatory arthritis pathogenesis. Our annual reports demonstrate multiple linked outputs in terms of publications, successful PhD studentships, industrial interactions and congress presentations. |
Collaborator Contribution | See above |
Impact | TBD |
Start Year | 2020 |
Description | RACE-2 Scientific Meeting, Glasgow |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | RACE is a four-partner academic consortium focussed on inflammatory arthritis pathogenesis. Our annual reports demonstrate multiple linked outputs in terms of publications, successful PhD studentships, industrial interactions and congress presentations. |
Collaborator Contribution | See above |
Impact | TBD |
Start Year | 2020 |
Description | RACE-2 Scientific Meeting, Glasgow |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | RACE is a four-partner academic consortium focussed on inflammatory arthritis pathogenesis. Our annual reports demonstrate multiple linked outputs in terms of publications, successful PhD studentships, industrial interactions and congress presentations. |
Collaborator Contribution | See above |
Impact | TBD |
Start Year | 2020 |
Description | RECORD: Strategies for cost-effective prescribing and use of biological and targeted synthetic DMARDs in inflammatory rheumatic diseases |
Organisation | François Rabelais University or University of Tours |
Country | France |
Sector | Academic/University |
PI Contribution | JDI was invited to be a partner in this consortium that will study, via systematic literature review, Delphi analyses, and discussions, ways to improve the cost-effective prescribing of targetted therapies for inflammatory rheumatic disease. |
Collaborator Contribution | This is an equal partnership, and all are contributing equally, although Radboud University Medical Centre is the coordinating site. |
Impact | Delphi questionnaire, one-to-one discussion and group discussion. Questions to be asked of the SLR have been formulated, and SLR has been completed. A manuscript is being developed for publication/dissemination. |
Start Year | 2020 |
Description | RECORD: Strategies for cost-effective prescribing and use of biological and targeted synthetic DMARDs in inflammatory rheumatic diseases |
Organisation | Karolinska Institute |
Country | Sweden |
Sector | Academic/University |
PI Contribution | JDI was invited to be a partner in this consortium that will study, via systematic literature review, Delphi analyses, and discussions, ways to improve the cost-effective prescribing of targetted therapies for inflammatory rheumatic disease. |
Collaborator Contribution | This is an equal partnership, and all are contributing equally, although Radboud University Medical Centre is the coordinating site. |
Impact | Delphi questionnaire, one-to-one discussion and group discussion. Questions to be asked of the SLR have been formulated, and SLR has been completed. A manuscript is being developed for publication/dissemination. |
Start Year | 2020 |
Description | RECORD: Strategies for cost-effective prescribing and use of biological and targeted synthetic DMARDs in inflammatory rheumatic diseases |
Organisation | King's College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | JDI was invited to be a partner in this consortium that will study, via systematic literature review, Delphi analyses, and discussions, ways to improve the cost-effective prescribing of targetted therapies for inflammatory rheumatic disease. |
Collaborator Contribution | This is an equal partnership, and all are contributing equally, although Radboud University Medical Centre is the coordinating site. |
Impact | Delphi questionnaire, one-to-one discussion and group discussion. Questions to be asked of the SLR have been formulated, and SLR has been completed. A manuscript is being developed for publication/dissemination. |
Start Year | 2020 |
Description | RECORD: Strategies for cost-effective prescribing and use of biological and targeted synthetic DMARDs in inflammatory rheumatic diseases |
Organisation | Radboud University Nijmegen Medical Center |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | JDI was invited to be a partner in this consortium that will study, via systematic literature review, Delphi analyses, and discussions, ways to improve the cost-effective prescribing of targetted therapies for inflammatory rheumatic disease. |
Collaborator Contribution | This is an equal partnership, and all are contributing equally, although Radboud University Medical Centre is the coordinating site. |
Impact | Delphi questionnaire, one-to-one discussion and group discussion. Questions to be asked of the SLR have been formulated, and SLR has been completed. A manuscript is being developed for publication/dissemination. |
Start Year | 2020 |
Description | RECORD: Strategies for cost-effective prescribing and use of biological and targeted synthetic DMARDs in inflammatory rheumatic diseases |
Organisation | Schlosspark-Klinik |
Country | Germany |
Sector | Hospitals |
PI Contribution | JDI was invited to be a partner in this consortium that will study, via systematic literature review, Delphi analyses, and discussions, ways to improve the cost-effective prescribing of targetted therapies for inflammatory rheumatic disease. |
Collaborator Contribution | This is an equal partnership, and all are contributing equally, although Radboud University Medical Centre is the coordinating site. |
Impact | Delphi questionnaire, one-to-one discussion and group discussion. Questions to be asked of the SLR have been formulated, and SLR has been completed. A manuscript is being developed for publication/dissemination. |
Start Year | 2020 |
Description | RECORD: Strategies for cost-effective prescribing and use of biological and targeted synthetic DMARDs in inflammatory rheumatic diseases |
Organisation | University of Auckland |
Country | New Zealand |
Sector | Academic/University |
PI Contribution | JDI was invited to be a partner in this consortium that will study, via systematic literature review, Delphi analyses, and discussions, ways to improve the cost-effective prescribing of targetted therapies for inflammatory rheumatic disease. |
Collaborator Contribution | This is an equal partnership, and all are contributing equally, although Radboud University Medical Centre is the coordinating site. |
Impact | Delphi questionnaire, one-to-one discussion and group discussion. Questions to be asked of the SLR have been formulated, and SLR has been completed. A manuscript is being developed for publication/dissemination. |
Start Year | 2020 |
Description | RECORD: Strategies for cost-effective prescribing and use of biological and targeted synthetic DMARDs in inflammatory rheumatic diseases |
Organisation | University of Leuven |
Country | Belgium |
Sector | Academic/University |
PI Contribution | JDI was invited to be a partner in this consortium that will study, via systematic literature review, Delphi analyses, and discussions, ways to improve the cost-effective prescribing of targetted therapies for inflammatory rheumatic disease. |
Collaborator Contribution | This is an equal partnership, and all are contributing equally, although Radboud University Medical Centre is the coordinating site. |
Impact | Delphi questionnaire, one-to-one discussion and group discussion. Questions to be asked of the SLR have been formulated, and SLR has been completed. A manuscript is being developed for publication/dissemination. |
Start Year | 2020 |
Description | RECORD: Strategies for cost-effective prescribing and use of biological and targeted synthetic DMARDs in inflammatory rheumatic diseases |
Organisation | Utrecht University |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | JDI was invited to be a partner in this consortium that will study, via systematic literature review, Delphi analyses, and discussions, ways to improve the cost-effective prescribing of targetted therapies for inflammatory rheumatic disease. |
Collaborator Contribution | This is an equal partnership, and all are contributing equally, although Radboud University Medical Centre is the coordinating site. |
Impact | Delphi questionnaire, one-to-one discussion and group discussion. Questions to be asked of the SLR have been formulated, and SLR has been completed. A manuscript is being developed for publication/dissemination. |
Start Year | 2020 |
Description | RTCure, Leiden |
Organisation | Leiden University |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Scientific Steering Group meeting. |
Collaborator Contribution | TBD |
Impact | TBD |
Start Year | 2020 |
Description | SOMAlogic (CRO) |
Organisation | SomaLogic |
Country | United States |
Sector | Private |
PI Contribution | Plasma samples from RA-MAP TACERA study and Vaccine study were provided for SOMAscan proteomics analysis, The resulting data have been extensively analysed by the industry members of the RA-MAP consortium. The cost of the analysis has been covered by crowd sourcing amongst the RA-MAP industry partners (£90K). |
Collaborator Contribution | Provision of SOMAscan proteomics analysis of TACERA baseline and 6 month plasma samples, and healthy control samples from the vaccine study. |
Impact | RA disease stratification of TACERA patients. |
Start Year | 2016 |
Description | Sensitivity and Specificity of RA Clinical Measurements |
Organisation | Newcastle University |
Department | Northern Institute for Cancer Research Newcastle |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | RA-MAP data on DAS28, SDAI, CDAI. Background to the analytical challenge. |
Collaborator Contribution | Statistical methods for clinical evaluations in which there is no gold-reference standard. |
Impact | Multidisciplinary - Medical Sciences, Mathematics & Statistics PhD thesis submitted. DRAFT paper in preparation as at 2021. |
Start Year | 2019 |
Description | SimOmics Ltd |
Organisation | Simomics Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Provision of RA-MAP omics dataset for systems immunology collaborative project |
Collaborator Contribution | SimOmics has been working closely with the team of systems immunologists in the RA-MAP consortium since Q1 2016. They contribute with systems analysis of RA-MAP RA omics database and metabolic flux analysis. |
Impact | None yet |
Start Year | 2016 |
Description | Tepnel Pharma Services |
Organisation | Tepnel Pharma Services |
Country | United Kingdom |
Sector | Private |
PI Contribution | Providing biological materials arising from TACERA clinical study cohort for RNA processing |
Collaborator Contribution | RNA processing and miicroarray services for samples deried from TACERA clinical study |
Impact | Tepnel has taken up the role of RNA processing and RNA microarray which feeds directly into Transcriptomics package of RA-MAP. |
Start Year | 2015 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | Cardiff University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | King's College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | National Institute for Health Research |
Country | United Kingdom |
Sector | Public |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | Queen Mary University of London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | University of Birmingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | University of Leeds |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | University of Nottingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | University of Southampton |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | Translational Research Collaboration for rheumatic and inflammatory diseases |
Organisation | Versus Arthritis |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Strategic Planning of experimental medicine studies. |
Collaborator Contribution | Strategic Planning of experimental medicine studies. |
Impact | A number of clinical trials have been completed and published |
Start Year | 2013 |
Description | WTCHG for NGS |
Organisation | University of Oxford |
Department | Oxford Genomics Centre |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | RA-MAP has provided RNA samples from TACERA clinical study cohort. |
Collaborator Contribution | Oxford Genomics has provided next generation sequencing of TACERA study RNA materials. |
Impact | Oxford Genomics has provided expertise in generating NGS data for RA-MAP consortium. |
Start Year | 2015 |
Description | 'Behind the scenes' - open evening event at the Manchester Royal Infirmary rheumatology department |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | "Behind the scenes" - open evening event was held at the Manchester Royal Infirmary rheumatology department, May 2015. Patients and carers were invited to meet staff and discuss research options - talks, examples of how research is conducted, opportunity to speak to research staff |
Year(s) Of Engagement Activity | 2015 |
Description | 'Platform for Investigation' Event at Manchester Muserum of Science and Industry |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Manchester researchers were involved in awareness-raising activities at the Manchester Museum of Science and Industry held in April 2015. One day event with 800+ visitors, mainly families with children. |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.cmft.nhs.uk/media-centre/latest-news/explore-joints-and-genes-at-the-museum-of-science-an... |
Description | 9th International Symposium on Uveitis Dublin 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Lecture on Biologics in Rheumatology |
Year(s) Of Engagement Activity | 2016 |
Description | ACR 2016 Abstract Selection Panel |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Co-chair of RA-aetiology and RA-pathogenesis categories. Reviewed 15 abstracts, selected those for presentation and ordered the session. |
Year(s) Of Engagement Activity | 2016 |
Description | ACR 2016 Washington |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Keynote address on 'Biologic Agents' |
Year(s) Of Engagement Activity | 2016 |
Description | APLAR 2021 - The important role of JAKs in the Treatment of Psoriatic Arthritis |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited to give a lecture at an industry-sponsored symposium at the Asia Pacific League of Associations for Rheumatology |
Year(s) Of Engagement Activity | 2021 |
URL | https://aplar2021.com/program/ |
Description | ARUK Arthritis Matters 2014 |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | There was useful discussion after my presentation about the reach of charitable funding Patients volunteered to join TRAFIC steering group |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.musculoskeletalresearch.com/2014/07/arthritis-matters-2014.html |
Description | ARUK Strategy Meeting Newcastle 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Strategy discussion with Liam O'Toole and Steve Simpson |
Year(s) Of Engagement Activity | 2016 |
Description | ARUK T-reg Workshop, London, 2018 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Supporters |
Results and Impact | A workshop that involved several charities and international experts. The goal to promote collaborative research and funding around the role of Tregs in autoimmune diseases. |
Year(s) Of Engagement Activity | 2018 |
Description | ARUK/CRUK Joint Planning Meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Joint planning meeting for symposium embracing common interests eg. checkpoint inhibitors. |
Year(s) Of Engagement Activity | 2016 |
Description | ASPIRE 2016 Research Awards |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Pfizer rheumatology research awards. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.aspireresearch.org/Rheumatology/index.html |
Description | Adherence Workshop - Manchester 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Organized by my ARUK CSG - workshop on treatment adherence. |
Year(s) Of Engagement Activity | 2016 |
Description | American College of Rheumatology (November 2015, California) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | PREVeNT RA Serum Biomarkers abstract was an abstract for a talk given by Prof Bruce at the ACR (American College of Rheumatology) November 2015 |
Year(s) Of Engagement Activity | 2015 |
Description | An Embrassment of Riches |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Participants in your research and patient groups |
Results and Impact | 100 individuals attended a session at BSR which I had organised, highlighting the importance of engaging patients in research This activity should improve recruitment to clinical trials, particularly from non-academic centres |
Year(s) Of Engagement Activity | 2013 |
Description | Antigen-Specific Immune Tolerance Europe, London, 2018 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Presented on RA-MAP and the TRC as examples of acadaemia-industry collaboration. Useful industry contacts on peptide therapeutics, CAR T-cells and other biotechnologies. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.as-immunetolerance-eu.com/ |
Description | BSI Immunotherapy Forum |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Third sector organisations |
Results and Impact | The British Society for Immunology Immunotherapy Forum white paper: The BSI Immunotherapy Forum (ITF): 1) Vision Embed the UK as a global superpower in next generation immunotherapy research and development to bring through life transforming treatments for patients 2) Mission The BSI Immunotherapy Forum will deliver a transformational shift in how the UK conducts immunotherapy research and development. Underpinned by the patient voice, we will exploit the unique ecosystem across academia, industry, the NHS and regulators, bringing together interdisciplinary stakeholders to facilitate and expedite research, translation and clinical delivery of next generation immunotherapies for patient benefit 3) Overarching aim of the ITF To establish an inclusive interdisciplinary Forum that brings together individuals and organisations involved in immunotherapy discovery, development and delivery within the UK to facilitate and expedite patient benefit across all diseases. Through providing a framework, Forum members will share their insight, expertise and networks to develop connections, collaborations, resources and advocacy to deliver against the following priority objectives on UK research: - Improve the effectiveness of discovery and translation research - Promote and facilitate 'team science' - Streamline the regulatory process - Optimise the use of treatments for patients to promote a holistic approach - Educate and train stakeholders in relevant topics - Advocacy through thought leadership The Forum will bring together academics, industry, clinicians, funding bodies, regulators and policy makers, and will have the patient voice at its heart. Bringing together immunotherapy researchers from different specialisms to learn from each other the Forum will focus on, and facilitate, the discovery and development of next generation immunotherapies as well as best clinical use of existing immunotherapies and combinations of immunotherapies. It will have a UK focus but keeping the global context in mind especially considering many UK based companies are global. The Forum as a whole will come together on a regular basis in a way that stimulates and facilitates scientific discussion and will be underpinned by topic-specific, impact-focussed, time-limited Task Forces. |
Year(s) Of Engagement Activity | 2021 |
Description | BSR 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Best practice in rheumatology research. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.rheumatology.org.uk/ |
Description | BSR 2016 Abstracts |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Reviewed 26 BSR Abstracts |
Year(s) Of Engagement Activity | 2016 |
Description | BSR 2016 Glasgow Signalling Pathways 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Chaired the Pfizer session on Signalling Pathways |
Year(s) Of Engagement Activity | 2016 |
Description | BSR Manipulating The Immune System - Birmingham |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | This was a lecture to rheumatologists in training on novel immunologically based therapies, at the annual BSR AGM. |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.eiseverywhere.com/ehome/rheumatology2017/423982/ |
Description | BT-CURE Workshop - Stockholm 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | AuToDeCRA Lecture and RT-CURE IMI proposal |
Year(s) Of Engagement Activity | 2016 |
Description | BT-CURE workshop May 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | This was a workshop of an existing EU-FP& consortium, which is now developing an IMI application for tolerogenic therapies in RA. I was invited to participate as a member of the proposed IMI academic/industry consortium |
Year(s) Of Engagement Activity | 2016 |
Description | Biomedical Research Unit Open Day (Manchester) - Disease Prevention |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | The Biomedical Research Unit (Musculoskeletal) in Manchester held its annual open day in May 2014, with this year's theme being on disease prevention. The open day provided staff from the regional institutions, hospitals and members of public to learn more about the research being carried out into disease prevention. This included a presentation given by Professor Ian Bruce on the PREVeNT RA study, introducing the study focussed on prevention of rheumatoid arthritis. Increased public awareness of currently on-going studies aimed at disease prevention, in particular rheumatoid arthritis. |
Year(s) Of Engagement Activity | 2014 |
Description | CLUSTER Consortium - London, 2018 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Study participants or study members |
Results and Impact | Strategic plans for MRC-funded stratified medicine programme in JIA and associated Uveitis. JDI chairs the external SAB. |
Year(s) Of Engagement Activity | 2018 |
URL | https://juvenilearthritisnews.com/2018/04/02/cluster-consortium-aims-improve-jia-uveitis-patients-li... |
Description | Cafe Scientifique (PREVeNT RA), Cockermouth, Cumbria |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | Professor Ian Bruce (PI for the PREVeNT RA study) gave a presentation of arthritis, based on his research. It provoked significant discussion about how lifestyle may influence arthritis development. |
Year(s) Of Engagement Activity | 2015 |
Description | Cafe Scientifique (PREVeNT RA), Pendle, Lancashire |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Professor Ian Bruce (PI for the PREVeNT RA study) gave a presentation of arthritis, based on his research. It provoked significant discussion about how lifestyle may influence arthritis development. Professor Bruce has been invited to give a further talk and the group sent a recording of his talk to other similar groups in England to raise awareness. |
Year(s) Of Engagement Activity | 2014 |
Description | Central & Eastern European Immunology Forum Bucharest 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | New Treatments for Immune Mediated Inflammatory Diseases |
Year(s) Of Engagement Activity | 2016 |
Description | Clinical Decision Making - Statistics and Health Economics |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Latent variable methods for clinical decision tools. |
Year(s) Of Engagement Activity | 2017 |
Description | Conservative Muslim Forum (London) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Professor Ian Bruce presented a talk to explore the question "Precision Medicine : An Achievable Goal?" He discussed how precisely can diseases be treated in a way that is specific to the individual patient. He gave an in depth analysis of research in Rheumatology and the fact that there are 8 million people affected by the disease. Despite the complexity of the subject, Professor Bruce managed to make it accessible to the layman. Professor Bruce alos talked about how research in the UK is fundedm and gave a breakdown of the various research being done by Medical Research Council and the National Institute of Health Research. Whilst the NHS's total budget is over £100 billion, the share devoted to research is under 3%. For most people, the most fascinating part of the evening was listening to Professor Bruce on the general theme of medication. He he talked about medicine being "partly art, partly science." Most drugs prescribing is on a trial and error / best guess basis, using the likely benefit to the average person. He talked about "personalised medicine" which would target the medicine to the individual patient, and "stratified medicine" which groups patients into categories to assess which medicine to use, being intermediate between using data for the average person and data for the specific individual. |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.conservativemuslimforum.com/news~events/news-&-past-events/health-event-precision-medicin... |
Description | DMC MATCH Macrophage Study Newcastle 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Study of macrophage therapy in liver cirrhosis. |
Year(s) Of Engagement Activity | 2016 |
Description | DRFZ Scientific Advisory Board Meeting Berlin 2016 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | DRFZ is Germany's premier Rheumatology Institute - Radbruch |
Year(s) Of Engagement Activity | 2016 |
Description | Drug Discovery Catapult - Alderley Park |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Third sector organisations |
Results and Impact | Discussions with the Medicines Discovery Catapult around access by SMEs to RA-MAP biobanked samples. |
Year(s) Of Engagement Activity | 2017 |
URL | https://md.catapult.org.uk/ |
Description | EMEUNET Meeting Lisbon 2016 Immune Tolerance - Where Next? |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Immune Tolerance: RA - Where Next? |
Year(s) Of Engagement Activity | 2016 |
Description | EMINENT GSK |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | To discuss a new funding stream from GSK and MRC for collaborative, experimental medicine research |
Year(s) Of Engagement Activity | 2015 |
Description | EMINENT Science Day and Scientific Co-ordinating Committee, Stevenage |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | EMINENT (Experimental Medicine Initiative to Explore New Therapies) is a consortium funded by GSK and MRC, with some contribution (eg towards fellowships) from NIHR. EMINENT brings together investigators from University College London (UCL), the University of Cambridge, the University of Glasgow, the University of Newcastle, Imperial College London and GlaxoSmithKline (GSK), with unprecedented access to GSK's unlicenced clinic-ready asset portfolio to enable experimental medicine studies aimed at enhancing understanding of disease mechanisms and accelerating development of novel therapeutics for patients in under-served disease areas. At this meeting our work on OSM< funded by EMINENT, was presented and discussed. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.ucl.ac.uk/eminent-consortium/ |
Description | EULAR - Cytokine Signalling Forum (CSF) presentation on JAK inhibitor selectivity |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Webinar at EULAR 2021 JAK inhibitors are advancing treatment and management options across immune-mediated inflammatory diseases. To understand the science of cytokine signalling and the effects of blocking different pathways, the CSF organised a symposium at the 2021 EULAR annual conference. The session explained the JAK-STAT pathway and described the mechanism of action of agents - both those approved and under investigation. We examined the clinical outcomes of JAK inhibition and invited the audience to submit questions to a live interactive discussion session. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.cytokinesignalling.com/en/publications/congress-highlights/590/#jak-selectivity |
Description | EULAR 2015 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Prospective collaboration with Pfizer |
Year(s) Of Engagement Activity | 2015 |
Description | EULAR 2016 London |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Chaired the satellite symposium on Biosimilars - Kweim, Dorner - presentation on Refractory RA |
Year(s) Of Engagement Activity | 2016 |
Description | EULAR 2019 Madrid |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | This symposium within the main congress focused on precision medicine It included updates on SLE, RA and psoriatic arthritis |
Year(s) Of Engagement Activity | 2019 |
Description | EULAR 2019 Organizing Committee |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Preparing for EULAR 2019 (Madrid). JDI is Abstracts Chair, a majpr role in the organising committee.. |
Year(s) Of Engagement Activity | 2018,2019 |
URL | https://www.congress.eular.org |
Description | EULAR 2020 Engagements |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Multiple contributions to EULAR 2020, as scientific chair of the organisation. >15000 attendees at this virtual event. "COVID-19 PARE" Presentation (PARE = People with Arthritis in Europe - an audience of patients) + Moderator "Dendritic Cells as Therapeutics" + Moderator "Arterial & Venous Risks in Inflammatory Rheumatic Diseases" + Moderator "Behcet's Disease" + Moderator "New Technologies in Translational Rheumatology" Additionally involved in a press conference/briefing |
Year(s) Of Engagement Activity | 2020 |
URL | https://rheumatology.medicinematters.com/eular-2020/coverage/17975292 |
Description | EULAR Research Centre, London, 2019 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Strategic discussions around a prospective, collaborative, virtual research centre for European Rheumatic and Musculoskeletal Disorders. |
Year(s) Of Engagement Activity | 2019 |
Description | EULAR Scientific Programme Committee |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Planning meeting for EULAR 2019 in Madrid. As Abstract Chair I play a major role in this meeting. |
Year(s) Of Engagement Activity | 2018 |
URL | http://congress.eular.org/index.cfm |
Description | EULAR Therapeutic Drug Monitoring Study Group, Amsterdam, 2018 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Chaired this EULAR Study Group reviewing therapeutic drug monitoring. Decision taken to apply for EULAR Task Force status in 2019. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.eular.org/clinical_affairs_study_groups.cfm |
Description | Efficient Medical Technology Development 2017 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Industry/Business |
Results and Impact | Facilitated workshop mapping roadblocks to the development pathway for new technologies. |
Year(s) Of Engagement Activity | 2017 |
Description | European Paediatric Rheumatology Congress - New Agents in RA |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | I gave a presentation to the annual Paediatric Rheumatology European Association (PRES) on "new agents being developed for inflammatory arthritis". Dear John Issacs, On behalf of the PReS Council and the Scientific Programme Committee, we would like to officially invite you to speak at the 27th European Paediatric Rheumatology Congress, from 19th to 21st September 2021. This year again PReS congress will be fully virtual, the Council and the Scientific Programme Committee wish to provide a high-quality e-congress and to pursue the PReS mission: Dedicated to advance the care and improve the health and well-being of children and young people with rheumatic conditions. We will be delighted to have your expertise and support on this adventure! You will find hereafter the details of your presentation: - Session title: (JIA) New Drugs/New Perspectives - Session date and time: Tuesday 21 September 2021, 09:00 - 10:00 - Duration of your talk: 20 minutes + 10 minutes Q&A (provisional) |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.pres.eu/pres2021/scientific-programme.html |
Description | European Workshop for Rheumatology Research, Lyon, 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Annual research workshop, provides the opportunity for postgrad students and ECRs to present their work to an international audience. One of our students had an oral presentation and another presented a poster. |
Year(s) Of Engagement Activity | 2019 |
URL | http://www.ewrr.org/ |
Description | Faculty visit to Dublin |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | THis was an information exchange between FMS at Newcastle and the equivalent at Trinity, Dublin. I presented our immunology portfolio and they did the same. Others talked about ageing and neuroscience research Successful meeting. |
Year(s) Of Engagement Activity | 2019 |
Description | GSK Industry Engagement Visit Newcastle 2016 |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Explored shared interests - potential for interaction - biopsy procedures |
Year(s) Of Engagement Activity | 2016 |
Description | Genesis Conference (London) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Mike Barnes presented a talk entitled: Technologies empowering Omics in the sessioin "Empowering Technologies" |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.cambridgeahead.co.uk/2015/12/genesis-2015-london-10th-december/ |
Description | Genomics Research in the NE Quadrant - York |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Participation in meeting on the future of genomics research in the NE Quadrant, as a component of NHS England's reorganisation of clinical genetics services. |
Year(s) Of Engagement Activity | 2018 |
Description | Great North Experimental Arthritis Treatment Centre website |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Participants in your research and patient groups |
Results and Impact | The activity is ongoing |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.greatneatcentre.com/ |
Description | IMID-BIO Cambridge, 2018 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | Annual scientific and strategic planning meeting for IMID-BIO UK. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.arthritisresearchuk.org/research/news-for-researchers/2017/december/our-role-in-the-worl... |
Description | IMID-BIO Science Day - Glasgow |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Scientific meeting of the IMID-BIO project, which brings together several stratified medicine consortia. |
Year(s) Of Engagement Activity | 2018 |
Description | IMID-BIO-UK 2020 Datathon Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | IMID-BIO-UK DATATHON with Industry and Academic Partners and Prospective Users. The purpose was to familiarise consortium members with the TransMART data warehouse that incorporates the various databases that make up IMID-BIO-UK |
Year(s) Of Engagement Activity | 2020 |
Description | IMID-BIO-UK Science Meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Scientific Meeting to discuss IMID-BIO-UK databases and biobanks and brainstorm research opportunities. |
Year(s) Of Engagement Activity | 2020 |
Description | Immune mediated Inflammatory Diseases Workshop: Wellcome Trust |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | This 2 day workshop brought together a wide spectrum of experts across immune mediated diseases to discuss challenges and future opportunities to learn more about immune mediated conditions. Several potential collaborations were discussed |
Year(s) Of Engagement Activity | 2017 |
Description | Immunogenicity Research Forum 2015 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Prospective collaborations |
Year(s) Of Engagement Activity | 2015 |
Description | International Forum for RA |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The International Forum for RA is a meeting focussed on cutting edge research in rheumatoid arthritis, with an emphasis on influencing future management strategies. I gave a presentation around 'smart trial designs'. This led to a new collaboration with Dana Orange (Rockefeller). |
Year(s) Of Engagement Activity | 2017 |
Description | International Psoriasis Council Symposium, Munich September 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | I spoke on P4 medicine in rheumatology and how such an approach can better address patient stratification |
Year(s) Of Engagement Activity | 2016 |
Description | Inventory of Trials Study Workshop on Predictors of Remission Study |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Participants in your research and patient groups |
Results and Impact | Workshop for the Predictors of Remission study was organised in Manchester by Prof Jane Worthington, Prof Deborah Symmons, Prof Ian Bruce and Ms Fiona Stirling. The workshop provided an opportunity to feed back information and analyses of the pooled clinical datasets from the 7 consortium member organisations. The meeting was successful, supported by approximately 20 participants contributing from these organisations (mixture of academic and industry partners). The findings of the study are planned to be incorporated into a manuscript under preparation by Prof Deborah Symmons. This workshop also promoted further data to be produced in order to strengthen the powering of the results. In addition, Brian Tom (study statistician for the RA-MAP consortium) was invited to speak at PSI (Statisticians in the Pharmaceutical Industry) conference in May 2015. |
Year(s) Of Engagement Activity | 2014 |
Description | JAKs in Rheumatology - Abbvie Webinar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presented overview of the potential role for JAK inhibition in the management of a variety of rheumatic diseases. |
Year(s) Of Engagement Activity | 2020 |
Description | JDRF Workshop - Common Mechanisms of Autoimmune Conditions |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Prospective collaborations |
Year(s) Of Engagement Activity | 2015 |
Description | Janssen Disease Area Stronghold Scientific Symposium Newark 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Featuring imaging presentations. |
Year(s) Of Engagement Activity | 2016 |
Description | Joint Effort Support Group, Alnwick |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | I gave a presentation entitled Modern Management of Rheumatoid Arthritis - a Cure is in Sight, to a regional National Rheumatoid Arthritis Society group Well received, lots of questions |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.nras.org.uk/groups/joint-effort-group-alnwick |
Description | Juvenile Diabetes Research Foundation Patrons Club Webinar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Date: Wednesday 29 April 2020 (World Immunology Day) Time: 6 - 7: 15pm Method: Online via Zoom Webinar Theme: Connect Immune Research Dress code: Business attire Number of guests: 120 (as of 24.04.20) Supported by: Insulet are the exclusive sponsor for the webinar Event Aims • To cultivate, steward and thank major donors including individuals (Patrons and Accelerator Programme donors) and representatives from companies that support JDRF • Act as a catalyst in encouraging donors (or would-be donors) to commit to multi-year gifts. There will be a 'call to action' (Urgent Patron Appeal) at the end of the panel discussion • Make guests feel energised and create a sense of excitement around the research JDRF is funding as well as the impact The Patrons' Club and Accelerator Programme have. Any guests that are not currently supporting us should feel motivated to start doing so. About The Patrons' Club The Patrons' Club is a giving club that raises significant funds that drive essential, world class research that will cure, treat or prevent type 1 diabetes. My discussion focussed on the overlap between different autoimmune diseases, and the potential for co-ordinated research into and management of a number of these conditions, including their associated comorbidities. There was significant interest in the event, which I understand led to significant fundraising for the charity. |
Year(s) Of Engagement Activity | 2020 |
URL | https://jdrf.org.uk/get-involved/corporate-trusts-philanthropy/philanthropy/ |
Description | Launch of the Medicines Discovery Catapult (January 2017, Alderley Park) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Industry/Business |
Results and Impact | The Catapult is an important partner for our BRC and this launch event introduced us to new collaborators and potential funding streams |
Year(s) Of Engagement Activity | 2018 |
Description | Lecture on "Stratified approaches to the treatment of rheumatoid arthritis" (Newcastle University MSc in Genomic Medicine) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Newcastle PI John Isaacs gave a lecture on stratified medicine in RA to the Genomics Medicine MSc at Newcastle University. This was provided to medical students who all work full time in the NHS. |
Year(s) Of Engagement Activity | 2016 |
Description | Leopoldina Symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | An invited seminar presented to an annual symposium, whose theme this year was precision medicine. The theme was 'The Precision Gap' - highlighting why inflammatory rheumatic disease is lagging behind oncology in the application of precision medicine. |
Year(s) Of Engagement Activity | 2020 |
URL | https://leopoldina-symposium.charite.de/en/ |
Description | MATURA Scientific Symposium - Manchester |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Scientific meeting bringing together the findings of the MATURA trial. Newcastle presented data on our proteomics analysis. |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.matura.whri.qmul.ac.uk/what_is_matura.php |
Description | MATURA Workshop 2017 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentations by ES and CMB |
Year(s) Of Engagement Activity | 2017 |
Description | MHRA 'visit' |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | As part of RT-CURE, myself and a colleague met with senior rheumatology advisers from the MHRA, to discuss our work, and prevention trials in general. We are already developing information for the EMA but, because of their move from London to Amsterdam, they are not currently seeking new activity, hence this visit. It was a fruitful exchange of information - they were v interested in our proposals for prevention trials and gave us some useful ideas as to what we will need to do before taking our document to EMA. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.gov.uk/government/organisations/medicines-and-healthcare-products-regulatory-agency |
Description | MRC DPFS Meeting - London |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | The DPFS scheme is a key part of the MRC's Translational Research Strategy and supports the translation of fundamental discoveries toward benefits to human health. It funds the pre-clinical development and early clinical testing of novel therapeutics, devices and diagnostics, including "repurposing" of existing therapies. Remit The scheme supports academically led projects whose goals are to improve prevention, diagnosis, prognosis, or treatment of significant health needs, or that focus on developing research tools that increase the efficiency of developing interventions. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.mrc.ac.uk/funding/browse/biomedical-catalyst-dpfs/biomedical-catalyst-developmental-path... |
Description | MRC DPFS Panel Meeting - London 2016 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Reviewed seven outline applications and two full applications for MRC Development Pathway Funding Scheme. |
Year(s) Of Engagement Activity | 2016 |
Description | MRC Newcastle University Visit |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Review and round table discussions of Newcastle University research outputs and statistics. |
Year(s) Of Engagement Activity | 2018 |
Description | MRC Platforms Workshop |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Michael Barnes presented a talk entitled "Platforms for Data integration" |
Year(s) Of Engagement Activity | 2015 |
Description | MRC RA-MAP CMB and PSG Meetings London 2016 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Strategic planning around future research directed at predictors of remission in RA. |
Year(s) Of Engagement Activity | 2016 |
Description | MRC Research Strategy Visit 2016 |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Reviewed medical research at Newcastle highlighting achievements in experimental medicine and translational research and identifying improvement opportunities. |
Year(s) Of Engagement Activity | 2016 |
Description | MRC Stratified Medicine Consortia in Immune-Inflammatory Diseases Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | This workshop explored common characteristics across a number of key consortia and has helped to better understand common challenges in the mechanisms of these conditions as well as common methodological challenges |
Year(s) Of Engagement Activity | 2016 |
Description | MRC Stratified Medicine Initiative - Strategy Workshop 2013 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | MRC Stratified Medicine Strategy Workshop 4th July 2013 London Science of Strat Med Consortia - Assisted the broader community in better understanding the opportunities and challenges posed by taking a stratified medicine approach |
Year(s) Of Engagement Activity | 2013 |
Description | MRC Stratified Medicine Meeting, London |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | This was a meeting to assess the MRC precision medicine portfolio and to make 'traffic light' decisions about progress to date, to be communicated to the grant holders. |
Year(s) Of Engagement Activity | 2019 |
Description | MRC Stratified Medicine, London, 2018 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | Review of progress for the MRC Stratified Medicine Consortia and Pathology Nodes. |
Year(s) Of Engagement Activity | 2018 |
Description | MRC TRG Meeting - London |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | The MRC Translational Research Group (TRG) is responsible for ensuring strong continued support for translational research across the MRC. It supports translational research across MRC funding Boards and Panels, through partnerships with other funders and major Higher Education Institutions and through dedicated funding schemes. Areas of particular focus for TRG include: The Biomedical Catalyst, an integrated translational funding programme jointly operated with Innovate UK (formerly the Technology Strategy Board). The Confidence in Concept scheme, supporting academically led feasibility research at the institutional level. The Developmental Pathway Funding Scheme, part of the Biomedical Catalyst, supporting translation of fundamental discoveries toward benefits to human health. The Methodology Research Programme, in partnership with the National Institute for Health Research (NIHR). Coordination with the MRC-NIHR Efficacy and Mechanism Evaluation Programme (EME) programme and other NIHR funding schemes to ensure suitable projects progress to late-stage trials. |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.mrc.ac.uk/about/our-structure/strategy-board-overview-groups/translational-research-grou... |
Description | MRC Technology Strategy Board Stratified Medicine Showcase |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | MRC Technology Strategy Board Stratified Medicine Showcase 30th Oct 2013 London Delivering the Impact To be reported |
Year(s) Of Engagement Activity | 2013 |
Description | MRC Translational Research Group 2016 Strategy Meeting |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Developing translational research strategy for the UK |
Year(s) Of Engagement Activity | 2016 |
Description | MRC/ABPI RA-MAP Final Meeting - London |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Sharing the research results of the RA-MAP project. |
Year(s) Of Engagement Activity | 2017 |
Description | MRCstratified medicine workshop April 2014 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Audience of approximately 20 PIs plus MRC staff - a view from the expert panel Enhanced recognition for Newcastle as a centre for translational medicine |
Year(s) Of Engagement Activity | 2014 |
Description | MSc Genomics Newcastle 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | Stratified Medicine in RA |
Year(s) Of Engagement Activity | 2016 |
Description | Manchester Rheumatology Forum: Therapeutic Tolerance - Myth or Reality? Curing autoimmune disease |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Online seminar with Q&A Dear Professor Isaacs, I am an academic clinical fellow in rheumatology working with Professor Ian Bruce at the University of Manchester. I arrange the monthly Manchester Rheumatology Afternoons (MRA) which is attended by North West rheumatology Specialist Trainees, regional consultants and university academics. I would like to take this opportunity to invite you to speak about a topic of your choice at one of the upcoming meetings. In my clinical work at the Royal Lancaster Infirmary, the consultants speak very highly of your 'difficult to treat RA' rheumatology clinics, and we would love to hear your insights into some of these cases; or some of the early phase experimental medicine studies you are working on presently. The afternoon provides both basic Specialist Trainee clinical teaching and continuing professional development for consultants. It usually begins with two case presentations, is followed by Consultant teaching and ends with the guest speaker. It is led by a North West rheumatology department and follows a theme. Due to the COVID-19 pandemic, we have cancelled all foreseeable face-to-face meetings. Moving forward, we would like to move to an online meeting using Zoom. |
Year(s) Of Engagement Activity | 2021 |
Description | Manchester postgraduate rheumatology meeting. Therapeutic Tolerance - Myth or Reality? Curing Autoimmune Disease |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation on advances in therapeutic tolerancing research to the Manchester postgraduate rheumatology meeting. |
Year(s) Of Engagement Activity | 2021 |
Description | Methodology for Stratified Medicine |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Prospective collaborations |
Year(s) Of Engagement Activity | 2015 |
Description | NE Inflammation Forum - Newcastle 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Pfizer chair - Coady, Goff, Sheikh, Taylor, Thompson. |
Year(s) Of Engagement Activity | 2016 |
Description | NHSA Meeting ( September 2017, Newcastle) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | NHSA meeting to plan collaborative work across the Northern BRCs |
Year(s) Of Engagement Activity | 2017 |
Description | NICE Diagnostic Advisory Committe, Manchester, 2019 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Development of draft recommendations on Therapeutic monitoring of TNF-alpha inhibitors in rheumatoid arthritis. These will be published for public consultation before formal recommendations are published. |
Year(s) Of Engagement Activity | 2019 |
Description | NIHR BRC Impact Showcase, Newcastle, 2018 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Showcase event attended by senior figures from the Department of Health and major charities including Versus Arthritis. The CEOs of the Trust and University attended. Musculoskeletal presentations included patient presentations and videos. Ken Baker was awarded a prize for best oral presentation. Sir John Burn and Dame Jackie Daniel presented their vision for Newcastle. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.newcastlebrc.nihr.ac.uk/events/nihr-newcastle-biomedical-research-centre-impact-showcase... |
Description | NIHR TRP Committee Meeting 2016 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | TRP strategic meeting. |
Year(s) Of Engagement Activity | 2016 |
Description | NIHR TRP Pipeline Meeting - London 2016 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Discussed pipeline and promotion of early stage trials - limitations of PIC sites - BRC roles |
Year(s) Of Engagement Activity | 2016 |
Description | NOVARTIS Biomedical Research Foundation (June 2017, Mayfair) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | A meeting between NIHR and Novartis to discuss potential engagement of Novartis in the UK |
Year(s) Of Engagement Activity | 2017 |
Description | NRAS magazine article |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Type Of Presentation | Paper Presentation |
Geographic Reach | National |
Primary Audience | Participants in your research and patient groups |
Results and Impact | Article on the importance of adherence to therapy for NRAS magazine This magazine has a wide circulation amongst patients with RA and is also available on-line |
Year(s) Of Engagement Activity | 2014 |
Description | Non-Pharmacological Interventions Workshop ARUK AIA CSG |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Prospective collaborations |
Year(s) Of Engagement Activity | 2015 |
Description | Open Innovation in the NHS workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | On the 2nd April 2014 the Academy of Medical Sciences hosted a workshop in partnership with the Centre for the Advancement of Sustainable Medical Innovation (CASMI) to bring together members of academia, industry, the NHS, funding bodies and IP experts. The discussion focused on the key issues and opportunities surrounding collaboration with the NHS, focusing particularly on 'open innovation' models of partnership. Professor Andrew Cope (PI of RA-MAP study) contributed by presenting the MRC/ABPI-funded RA-MAP consortium as an exemplar of open innovation in the NHS and model of academia-NHS-industry collaboration. Delegates enjoyed four case presentations that highlighted the advantages of open collaboration models and also some of the barriers and frustration involved with these partnerships. Following a candid and constructive period of discussion, delegates highlighted four areas that they considered to be the most significant barriers to open innovation. These were: lack of metrics, poor incentivisation and reward for innovation, cultural conflicts between sectors and poor use of existing structures. Delegates then worked in groups to consider novel solutions to overcoming these barriers and facilitate open innovation partnerships with the NHS. |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.acmedsci.ac.uk/policy/policy-projects/open-innovation-in-the-nhs/ |
Description | Personalized Medicine - Brazil 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Lecture tour presenting four talks on Personalized Medicine at three research centres in Brazil. |
Year(s) Of Engagement Activity | 2016 |
Description | Pfizer 2016 Berlin Meeting to develop educational materials around Tofactinib treatment. |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Meeting to develop educational materials to support Tofactinib treatment sponsored by Pfizer. |
Year(s) Of Engagement Activity | 2016 |
Description | Pfizer EARTH Ad Board - Paris 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Co-chaired the Ad Board |
Year(s) Of Engagement Activity | 2016 |
Description | Pfizer JAK Inhibition Symposium 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talks and informal discussions on RA pathophysiology and potential novel treatments. |
Year(s) Of Engagement Activity | 2016 |
Description | Pharmacology of Selectivity - Saudi Arabia Rheumatologists |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | I was invited to present at an industry-sponsored event. Small group discussion with Q&A. |
Year(s) Of Engagement Activity | 2021 |
Description | Portuguese Congress of Rheumatology 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Networking and strategic planning with international collaborators. |
Year(s) Of Engagement Activity | 2016 |
Description | Portuguese Society of Rheumatology - Algarve 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Keynote Lecture - New Treatments for IMID - invited paper to Annals Review |
Year(s) Of Engagement Activity | 2016 |
Description | Precision Medicine UK |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | NOCRI joined UK leaders in the research, development and commercialisation of precision medicine for a one-day event this week designed to encourage new partnerships and highlight new opportunities in the field. The Precision Medicine UK: Collaboration Nation event at De Vere Holborn Bars, London, on 9 December was organised on behalf of the Stratified Medicine Innovation Platform by Innovate UK,, National Institute for Health Research, Cancer Research UK,Medical Research Council, Invest Northern Ireland, Health and Care Research Wales and the Knowledge Transfer Network, with the NIHR Office for Clinical Research Infrastructure (NOCRI) coordinating the NIHR's involvement. The day formed part of a programme to make the UK a world leader in precision medicine and provided real-world examples of the discovery and development of precision medicine solutions, through talks, panel discussions, workshops and exhibitions with the opportunity to arrange one-to-one partnering meetings. Precision medicine is an emerging approach to the treatment and diagnosis of disease that takes into account variations in a patient's genes, environment and lifestyle. It aims to better target treatments to an individual's circumstances to improve outcomes for patients. Representatives from across the NIHR were involved in the day and presented on a range of projects and funding programmes. Professor Bryan Williams of NIHR UCLH Biomedical Research Centre joined the first panel of the day which highlighted UK investments in the invention and evaluation phase of research. Professor Williams' highlighted key NIHR's investments in this space and provided examples of exciting precision medicine projects from UCLH BRC. In addition, a number of NIHR precision medicine projects were presented during the disease area specific showcase sessions. This included Professor Costantino Pitzalis who presented the THERAPIST study on behalf of the NIHR Translational Research Partnership, Professor Simon Mead's who presented a project at NIHR Queen's Square Biomedical Research Unit on the "dementia chip" and Professor Tariq Sadiq's who presented on Capacity Building and Delivery of Precision Medicine in Sexual Health, through NIHR Funding. Mark Samuels, Managing Director of NOCRI, also chaired a discussion panel themed 'Enabling Collaboration', which highlighted the value of collaborative working between companies, academics, charities and patients. The event saw the launch by the chief executive of Innovate UK, Dr Ruth McKernan, of a new map of the precision medicine landscape. A whole range of organisations, including charities, health bodies and devolved administrations are coordinating their work under the umbrella of Innovate UK's Stratified Medicine Innovation Platform, with NOCRI representing the NIHR. |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.uk-pgx-stratmed.co.uk/index.php/event-calendar/icalrepeat.detail/2015/12/09/213/73/- |
Description | Presentation to Industrial partners at American Congress of Rheumatology meeting in San Diego |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Approximately 40 attendees from 18 different companies. Introduced the NHIR Translational Research Partnership to them. (Title: the NIHR Translational Research Partnership). Several contacts subsequent to the meeting with potential collaborative research ensuing. |
Year(s) Of Engagement Activity | 2013 |
Description | R&D conference. Health Research - partnerships for success |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | This was a conference at BMA House organised by ABPI, BIA and NOCRI - to explain largely to an industrial audience, how the collaborative landscape (Industry/academia) was evolving. Other speakers included Lord Howe and Sir John Savill. There were approximately 250 attendees. New contacts from potential industrial collaborative partners |
Year(s) Of Engagement Activity | 2012 |
Description | RA Expert Exchange Scientific Event |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presented at three successive daily events sponsored by Abbvie. The audience was Italian rheumatologists in different regions of Italy. The theme was the mode of action of JAK inhibition with a focus on selectivity. |
Year(s) Of Engagement Activity | 2021 |
Description | RA Expert Exchange Scientific Event with Italian Rheumatologists |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | This was a virtual industry-sponsored event, over three consecutive days, involving seminars from an international panel with Italian rheumatologists. I spoke about the mode of action of JAK inhibition and the remaining unmet need for people with RA. 6 seminars over three days (3 x 2). |
Year(s) Of Engagement Activity | 2021 |
Description | RA-MAP Biostatistics overview (presentation at MATURA meeting) |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | RA-MAP Biostatistics Overview was presented by Brian Tom (RA-MAP statistician PI) at MATURA Scientific Meeting, where the statistical approaches used in RA-MAP were outlined, which may be relevant to the MRC Stratified Medicine Initiative MATURA consortium |
Year(s) Of Engagement Activity | 2017 |
Description | RA-MAP Presentation at PSI Immunology Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Industry/Business |
Results and Impact | Brian Tom, the leading PI statistician of RA-MAP, provided RA-MAP project overview and statistical approaches taken in a presentation given at PSI (Promoting Statistical Insight) Immunology meeting to industry statisticians. |
Year(s) Of Engagement Activity | 2016 |
Description | RA-MAP data infrastructure and analysis strategy presented at Wellcome Trust Immune Modulated Inflammatory Disease Workshop (Feb 2017) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | RA-Map data infrastructure and analysis strategy was presented |
Year(s) Of Engagement Activity | 2017 |
Description | RA-MAP data infrastructure was presented as an exemlar at the MRC Stratified Medicine Applicats Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | RA-Map data infrastructure was presented as an exemplar at the MRC Stratified Medicine applicants workshop |
Year(s) Of Engagement Activity | 2017 |
Description | RA-MAP project presentation as a Startified Medicine exemplar at the MRC-eMedLab Stratified Medicine Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | The RA-Map project was presented as a Stratified Medicine exemplar at the MRC-eMedLab Stratified Medicine workshop |
Year(s) Of Engagement Activity | 2016 |
Description | RA-MAP website |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | The RA-MAP website is currently hosted by Newcastle University but serves the needs of Consortium members - the numerous industry and academic partners making up the RA-MAP consortium. |
Year(s) Of Engagement Activity | 2017 |
URL | http://research.ncl.ac.uk/ra-map/ |
Description | RA/MAP Closure meeting (June 2017, London) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Closure of the RA MAP consortium with presentations on relevant outputs and future plans |
Year(s) Of Engagement Activity | 2017 |
Description | RACE Scientific Advisory Board Meeting 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentations on TRAFIC and BIO-FLARE as worked examples of our experimental medicine approach. |
Year(s) Of Engagement Activity | 2016 |
Description | RACE Scientific Meetings |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Active participation in RACE Scientific Meetings bringing together arthritis researchers and patient partners. There are three or four meetings per year , attended by collaborators, students and patient partners. The patient partners form an important constituency and a major effort is made to ensure that presentations are suitable for such an audience |
Year(s) Of Engagement Activity | 2019,2020,2021 |
URL | https://www.race-gbn.org/news/ |
Description | RACE Second International Scientific Advisory Board Meeting, Glasgow, 2018 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Study participants or study members |
Results and Impact | Scientific presentations and patient-focused discussions. Excellent feedback from the panel, which has influenced.renewal plans. |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.race-gbn.org/communityengagement/ |
Description | RACE launch |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Participants in your research and patient groups |
Results and Impact | Interesting discussions, including with an Olympian None yet |
Year(s) Of Engagement Activity | 2014 |
Description | RT CURE annual meeting Visegrad |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | AGM of RT-CURE. I provided an update of WP6 (clnical trials), including AuTDeCRA 2. I also hosed a trial design workshop, where we determined that a platform trial would be the optimal design for RT-CURE trials. Patients were involved in all presentatons and, as an IMI consortium, there are several companies engaged. |
Year(s) Of Engagement Activity | 2016,2019 |
URL | https://www.rtcure.com/ |
Description | RT CURE-AMP meeting, Washington DC |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | This was a workshop attached to the IFRA (International Forum on Rheumatoi Arthritis) to foster collaboration between EU (RT-CURE), US (Accelerating Medicines Partnership), and Chinese rheumatologists. I presented two talks at the meeting, one on the RT-CURE consortium and one on experimental medicine trial designs, where I included AuToDeCRA 2, |
Year(s) Of Engagement Activity | 2019 |
URL | https://fnih.org/what-we-do/programs/ifra2019 |
Description | RT-CURE Annual Meeting, Beerse, 2018 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Study participants or study members |
Results and Impact | Annual meeting of the RT-CURE consortium. Excellent meeting with welcome patient partner participation. |
Year(s) Of Engagement Activity | 2018 |
Description | Remission Accomplished - Houses of Parliament |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | There was an active discussion around the therapy of inflammatory arthritis and its future direction. None yet |
Year(s) Of Engagement Activity | 2014 |
Description | Research Engagement Poster Campaign 2015 |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Poster campaign describing research in lay terms for public and patients audience. To promote engagement in research in the NE. Public and patients expressed interest in participating in research. |
Year(s) Of Engagement Activity | 2015 |
Description | Rheumatoid Arthritis - What Next? University of Washington Grand Rounds webinar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation, discussion and University of Washington webinar. I was invited to present a research seminar to the University of Washington Rheumatology Grand Rounds, and participate in several one:one meetings with Faculty members. Dear John, I think that we met briefly at one of the rheumatology meetings in the pre-COVID era (?). The reason that I am contacting you is that for the new academic year (beginning in September, 2021) , we are inviting distinguished international speakers to present at our UW Grand Rounds Series by Zoom. The Division of Rheumatology hosts its Grand Rounds on Tuesday mornings at 9 am PST (around 5 pm your time). We hope that you will accept the invitation to give a seminar on Rheumatoid Arthritis? If there are specific dates you prefer (preferably between September and February), please let us know. With best regards, Keith Keith Elkon, MD Mannik-Henderson Professor of Medicine Head, Division of Rheumatology Adjunct Professor of Immunology Associate Director, Center for Innate Immunity and Immune Diseases University of Washington Rm E541, Mailbox 358060 |
Year(s) Of Engagement Activity | 2021 |
URL | https://youtu.be/9e93k-zR9SE |
Description | Rheumatoid Arthritis Strategic Review, Newcastle, 2015 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Strategic realignment of research activities |
Year(s) Of Engagement Activity | 2015 |
Description | Rheumatoid Arthritis: What's New? Karolinska, Sweden 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Novel and targeted RA treatments. |
Year(s) Of Engagement Activity | 2016 |
Description | Rheumatology Research Patient Partnership (R2P2) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Education and empowernig Patient Partners to participate in research design and oversight. Education and empowering Patient Partners to participate in research design and oversight. The Rheumatology Research Group in Birmingham recognise the importance of involvement of patients and members of the general public in all aspects of the research process, including initial project development and grant applications, the design and implementation of the studies as well as their dissemination. |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.birmingham.ac.uk/research/activity/mds/projects/ii/R2P2/index.aspx |
Description | Roche Systems Pharmacology Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | A systems approach to investigating drug response variability in RA |
Year(s) Of Engagement Activity | 2015 |
Description | Royal College of Physicians of Edinburgh Therapeutic Drug Monitoring Conference, Edinburgh, 2018 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Workshop focussed on therapeutic drug monitoring for biologic therapies including round table discussion and establishment of a working group. |
Year(s) Of Engagement Activity | 2018 |
Description | Scandinavian Congress of Rheumatology - Therapeutic Monitoring of Biologics |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation, Q&A. Dear Professor John Isaacs Based on your expertise and scientific reputation, it is our great pleasure to invite you to contribute to the Scandinavian Congress of Rheumatology 2020, which will be held at Scandic Parken Hotel in Ålesund, Norway September 2nd - 5th 2020. Our main goal is to present an excellent scientific program. We would be honored if you accept this invitation to present as follows: Track: Treatment Session: Towards a more personalised treatment of arthritic diseases Title of the lecture: The role of therapeutic drug monitoring of biological drugs Date: Thursday September 3rd 2020 Time of lecture: 9:30 AM to 10:00 AM The SCR congress is organised by the Scandinavian Society of Rheumatology every other year, alternating between Denmark, Finland, Norway, Iceland and Sweden. The official congress language is English and the congress usually gathers 500-600 participants. |
Year(s) Of Engagement Activity | 2021 |
Description | Seminar at Altnagelvin Hospital |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Prof Ian Bruce provided a seminar about pevention of RA based on PREVENT RA study. |
Year(s) Of Engagement Activity | 2015 |
Description | South African Immunology Society - Autoimmunity in rheumatoid arthritis - can it be curtailed? |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Asked to give a lecture to the South African Immunology Society Dear Prof Isaacs I am part of the organising committee of the South African Immunology Society (SAIS) conference. I was referred by Prof Mohammed Tikly to approach you. Would you be able to speak for about 25 min on Auto-immunity and Rheumatology on Tuesday, 1 September? It will be a virtual conference so we will ask that you record the presentation before the conference and then be available for questions in the allocated time slot. I hope you will be amicable to share your knowledge with us. Kind Regards |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.saimmunology.org.za/conferences/2021/files/SAIS%20Programme%20-%20%2029%20Aug%20-%20Webs... |
Description | Stockholm - RA: What's Next - 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited Lecture |
Year(s) Of Engagement Activity | 2016 |