Omega-1, a novel immunomodulator with potential to prevent Type 1 diabetes?

Lead Research Organisation: University of Cambridge
Department Name: Pathology

Abstract

Type 1 diabetes is an autoimmune disease which is increasing dramatically
in incidence in the UK. The reasons behind this increase are unknown but
one explanation is that a reduced exposure to infectious agents may be
responsible.We have previously shown using a mouse model of type 1
diabetes that extracts of a parasite are able to inhibit development of
diabetes in this mouse strain. It is not necessary to have a live
infection to achieve diabetes prevention. Our studies furthermore show
that prevention is achieved by increasing regulation of the immune
response. We have preliminary data showing that a purified product of the
parasite is able to induce a population of cells involved in immune
regulation. We propose to see whether this product can inhibit diabetes in
our mice, whether it can also induce human regulatory cells and dissect
how a single molecule can do this. The importance of this work is that it
may lead to the development of a novel biomodulator that can be used to
prevent diabetes onset in humans.

Technical Summary

Omega-1 is a glycoprotein produced by the helminth Schistosoma mansoni. We find that this glycoprotein can induce Foxp3 expression, a marker of regulatory T cells, in na?ve CD4+T cells from NOD mice. As our previous studies have shown that extracts containing this glycoprotein can prevent diabetes onset in the NOD mouse model of T1D we propose to determine whether Omega-1 induces functional regulatory T cell activity in T cells from both NOD mice and T cells from diabetic patients. We will furthermore characterise the signalling pathways involved when Omega-1 interacts with the immune system. We will additionally determine whether Omega-1 is able to prevent diabetes onset in NOD mice.

Publications

10 25 50

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Cooke A (2012) Parasitic worms and inflammatory disease. in Current opinion in rheumatology

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Hall SW (2011) Autoimmunity and inflammation: murine models and translational studies. in Mammalian genome : official journal of the International Mammalian Genome Society

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Wållberg M (2013) Immune mechanisms in type 1 diabetes. in Trends in immunology

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Zaccone P (2011) Infectious triggers protect from autoimmunity. in Seminars in immunology

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Zaccone P (2013) Helminth mediated modulation of Type 1 diabetes (T1D). in International journal for parasitology

 
Description Annual Cogress British Society for Immunology Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This was given to an audience of 100s.

BSI Congress, LIverpool, December 2011
Parasite modulation of autoimmune diseases

Paola Zaccone,Oliver T Burton, Gabriele Schramm, Helmut Haas, Michael J Doenhoff, David W Dunne and Anne Cooke



Dr Zaccone has been asked to attend further conferences and present data.
Year(s) Of Engagement Activity 2011
URL http://www2.kenes.com/bsi2011/ScientificProgramme/Documents/BSI-WebSite-Prospectus.pdf
 
Description Beta cell workshop in Elsinore 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The conference was
,"Programming Beta Cell Development, Impairment and Regeneration," will be held at LO-Skolen in Helsingør (Elsinore), Denmark on October 23 to 26, 2011.
The talk was
How might infection modulate the onset of type 1 diabetes?
Anne Cooke, Oliver Burton and Paola Zaccone


Made contacts with beta cell biologists
Year(s) Of Engagement Activity 2011
 
Description Cambridge International Science Summer School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact The audience comprised around 70 people who were a mix of school children and others interested in continuing education.

Some of the students asked to see the laboratories and wanted advice about how to carry out a career in science.
Year(s) Of Engagement Activity 2010,2011
URL http://www.ice.cam.ac.uk/courses/summer-schools/summer-school-programmes/science
 
Description Helminth Conference in Hydra, Greece 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This was a selected meeting to discuss and present data related to the potential for immunotherapy of inflammatory diseases using helminths. The meeting was held on the Greek island of Hydra. The talk was entitled
S mansoni antigens and autoimmune diabetes; linking effects on the immune system with insulin resistence and glucose homeostasis.
Samuel H Hall, Paola Zaccone, Sarah Gibbs, David Dunne and Anne Cooke


This conference was partly funded by Coronado Biosciences a company that promotes helminth therapy for the treatment of autoimmune and inflammatory disease and has emerged from the studies of several of us in the field who have shown beneficial effects of exposure to helminths or their products.
Year(s) Of Engagement Activity 2013
URL http://hydra-themes.bio.ed.ac.uk/hydra-2013-registration
 
Description Keystone Symposium Type 1 Diabetes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact I was a meeting organiser and also gave a talk.
The meeting was Immunopathology of Type 1 Diabetes - Keystone Symposia , Whistler, Canada
The talk was entitled
Epigenetic modification of induced Tregs: implications for therapy L Bruno, J Phillips, M Merkenschlager and A Cooke

Established lots of new contacts
Year(s) Of Engagement Activity 2013
URL http://www.keystonesymposia.org/index.cfm%3Fe%3DWeb.Meeting.Registration%26meetingid%3D1236...
 
Description Pint of Science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact I gave a talk in The Panton Arms to the general public on 16th May 2013 entitled "Can we worm our way out of trouble?".The event was fully booked in terms of attendance with between 30-40 in the audience. there was a lively discussion after the talk. The audience seemed to fully engaged.

The questions from the lay audience were really very good and afterwards many came up to chat to me informally and register great interest.
Year(s) Of Engagement Activity 2013
 
Description Shanghai lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact I was invited to give a seminar in the prestigious Er Yi Innovation Forum at Faculty of Basic Medicine and Institutes of Medical Sciences at Shanghai Jiao Tong
University School of Medicine. The audience was a mix of students and scientists

It gave Anne Cooke the opportunity to interact with young Chinese scientists and students
Year(s) Of Engagement Activity 2013