An investigation of parent-child interactions in anxious adolescents and a pilot evaluation of a novel family treatment

Lead Research Organisation: University of Reading
Department Name: Sch of Psychology and Clinical Lang Sci

Abstract

One in twenty British adolescents has an anxiety disorder. These disorders are more common and severe than in younger children. There is a psychological treatment, cognitive-behaviour therapy, which is effective in treating anxiety disorders in young people generally. However, treatments do not adequately address the specific needs of adolescents. There is evidence that parents of anxious children are less likely to let their children do things for themselves, and also respond in fearful ways to challenging situations, compared to parents of non-anxious children. Early reports suggest similar patterns may occur within families of anxious adolescence. This research has the following aims: first, to understand the family processes experienced by anxious adolescents; second, to conduct experiments to establish whether parentsā€˜ behaviours lead to adolescent anxiety; and finally, to develop and test a new psychological treatment through a small clinical trial with anxious adolescents and their parents to target the key parental behaviours that contribute to adolescent anxiety. This research has the potential to have a significant impact on clinical practice by providing greater understanding of adolescent anxiety and improving therapeutic techniques to more effectively treat anxiety in adolescence.

Technical Summary

Aims

Anxiety disorders in adolescents are common and disabling; indeed they are known to be more common, severe and co-morbid than in younger children. However, although cognitive-behaviour therapy (CBT) has been demonstrated to be effective in treating anxiety disorders in young people, treatments have been developed principally for children and the specific needs of adolescents have not been adequately addressed. There is evidence that parents of anxious children are more controlling and model more avoidant behaviour than parents of non-anxious children. Family factors appear also to be a significant factor in relation to adolescent anxiety, however studies are limited in the extent to which causal associations can be concluded. The aims of the proposed research are to (i) clarify the family processes experienced by anxious adolescents, in comparison to anxious children and non-anxious adolescents; (ii) establish experimentally whether family processes have a causal influence on adolescent anxiety; (iii) develop and pilot a novel cognitive-behavioural treatment that targets the key parental processes which maintain adolescent anxiety.

Objectives

1. To conduct a systematic cross-sectional observational study to enhance understanding of the family processes associated with adolescent anxiety.

2. To conduct experimental studies to test the causal link between parenting behaviours identified in the observational study and anxiety in adolescents.

3. To conduct a pilot study of a parental-behaviour focused adjunct to standard CBT for adolescent anxiety.

Design

1. Three groups will be recruited (i) anxious adolescents, (ii) non-anxious adolescents, and (iii) anxious children. Assessments will be made of anxiety symptoms and diagnoses, common co-morbid disorders and parent-offspring interactions. Observational assessments of interactions between participants and their primary caregiver will be made and rated.

2. Experimental studies will be carried out with non-anxious adolescents and their primary caregiver. This will involve manipulating caregiver behaviour via training and then asking them to support their adolescent perform a challenging task. Adolescent response to the task will be assessed.

3. Clinically anxious adolescents will be randomised to receive either CBT + control family intervention or CBT + parent-focused intervention that targets behaviours identified in the observational and experimental studies.

Scientific and medical opportunities

The proposed research is of both scientific and clinical importance as it will (i) contribute to a greater understanding of the role of family factors in adolescent anxiety, and (ii) improve clinical interventions for anxious adolescents.

Publications

10 25 50

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Coleman JR (2016) Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders. in The British journal of psychiatry : the journal of mental science

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Creswell C (2014) Assessment and management of anxiety disorders in children and adolescents. in Archives of disease in childhood

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Creswell C (2020) Practitioner Review: Anxiety disorders in children and young people - assessment and treatment. in Journal of child psychology and psychiatry, and allied disciplines

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Hill C (2016) Anxiety disorders in children and adolescents in Paediatrics and Child Health

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Hudson JL (2015) Clinical Predictors of Response to Cognitive-Behavioral Therapy in Pediatric Anxiety Disorders: The Genes for Treatment (GxT) Study. in Journal of the American Academy of Child and Adolescent Psychiatry

 
Description Attentional control study 
Organisation University of Leuven
Country Belgium 
Sector Academic/University 
PI Contribution We are collaborating on research on attentional control deficits in adolescents with anxiety disorders, which has involved administering 2 measures of attentional control to adolescents pre and post-treatment.
Collaborator Contribution The design of the study, selection of measures
Impact No output as yet.
Start Year 2013
 
Description Berkshire Healthcare NHS Trust 
Organisation Berkshire Healthcare NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution This study provided rigorous clinical assessments and treatment of clinically anxious adolescents.
Collaborator Contribution Participants from clinical populations in the research and treatment trial were recruited from GPs, CAMHS and other services in Berkshire Healthcare NHS Trust.
Impact 60 clinically anxious adolescents have taken part in our randomised controlled trial evaluating an internet-based CBT treatment. We are in the process of completing assessments at 6-month follow-up. We have undertaken qualitative assessments of their satisfaction with the internet treatment. We have completed an evaluation of the clinical characteristics of the children and adolescents referred to the local NHS CAMHS. This has led to 2 published papers and a further 3 in preparation.
Start Year 2012
 
Description Genetic studies 
Organisation King's College London
Department MRC Social Genetic and Developmental Psychiatry Centre (SDGP)
Country United Kingdom 
Sector Academic/University 
PI Contribution The study has involved collection of DNA samples from participants with anxiety disorders and their parents as part of a large, multisite study.
Collaborator Contribution DNA data was analysed by a behavioural geneticist at KCL.
Impact The collaboration has contributed towards data that has been analyzed and disseminated through 3 publications in peer-reviewed journals (and a further 2 under review) and presentation at international conferences. Hudson, J.L., Keers, R., Roberts, S., Coleman, J.R.I., Breen, G., Arendt, K., Bogels, S., Cooper, P., Creswell, C., Hartman, C., Heiervang, E., Hötzel, K., In-Albon, T., Lavallee, K., Lyneham, H.J., Marin, C., McKinnon, A., Meiser-Stedman, R., Morris, T., Nauta, M., Rapee, R.M., Schneider, S., Silverman, W.K., Thastum, M., Thirlwall, K., Waite, P., Wergeland, G.K., Lester, K.J. & Eley, T.C. The Genes for Treatment study: A multi-site trial of clinical and genetic predictors of response to Cognitive Behaviour Therapy in paediatric anxiety disorders. (under review at the Journal of the American Academy of Child and Adolescent Psychiatry). Lester, K.J., Roberts, S., Coleman, J.R.I., Breen, G., Xu, X., Keers, R., Wong, C., Blatter-Meunier, J., Bogels, S., Cooper, P., Creswell, C., Hartman, C., Heiervang, E., Herren, C., Hudson, J.L., Jonsson, H., Krause, K., Lyneham, H.J., McKinnon, A., Morris, T., Nauta, M., Rapee, R.M., Rey, Y., Schneider, S., Silverman, W.K., Smith, P., Thastum, M., Thirlwall, K., Waite, P., Wergeland, G.J. & Eley, T.C. The 5HTTLPR and response to psychological therapy - an update. (accepted by British Journal of Psychiatry). Coleman, J.R.I., Lester, K.J., Curtis, C., Roberts, S., Keers, R., Arendt, K., Bogels, S., Cooper, P., Creswell, C., Dalgleish, T., Hartman, C., Heiervang, E., Hötzel, K., Hudson, J.L., In-Albon, T., Lavallee, K., Lyneham, H.J., Marin, C., Meiser-Stedman, R., Morris, T., Nauta, M., Rapee, R.M., Schneider, S., Silverman, W.K., Thastum, M., Thirlwall, K., Waite, P., Wergeland, G.J., Breen, G. & Eley, T.C. Genome-wide association study of response to cognitive behavioral therapy in children with anxiety disorders. (under review at Molecular Psychiatry).
Start Year 2006
 
Description Griffith University 
Organisation Griffith University
Country Australia 
Sector Academic/University 
PI Contribution Our study is extending the research undertaken at Griffith University, examining the clinical effectiveness of a computerised treatment for anxiety disorders in adolescence in a U.K., referred population.
Collaborator Contribution Researchers at Griffith University designed and developed the computerised treatment for anxiety disorders in adolescence that is being evaluated in this study.
Impact This has led to further collaboration, joint dissemination of research work through symposiums at international conferences.
Start Year 2012
 
Description SCAS evaluation in ASD 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution We have provided data for clinically anxious adolescents without autistic spectrum disorders, as a comparison group to study the Spence Child Anxiety Scale in young people with Autistic Spectrum Disorders (ASD)
Collaborator Contribution They have set up and designed the study and collected data for young people with ASD.
Impact No outcomes as yet.
Start Year 2013
 
Title A pilot randomised controlled trial of an internet-based Cognitive behavioral therapy (CBT) treatment for adolescent anxiety 
Description Internet delivered Cognitive Behaviour Therapy for adolescents with an anxiety disorder, developed and evaluated in Australia and now being evaluated with a UK, referred population 
Type Therapeutic Intervention - Psychological/Behavioural
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2011
Development Status Closed
Clinical Trial? Yes
Impact This treatment is now being used within the local CAMHS service. 
URL http://www.controlled-trials.com/ISRCTN79652741/ISRCTN79652741
 
Description 2 Day Workshop (Chessington TAMHS, 17-18/06/13, 03-04/03/14) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact 2 day workshop on psychological treatment of anxiety in children and adolescents for Chessington TAMHS with ~15 education professionals, involving questions, discussion and practice of treatment techniques

Increased awareness and improved treatment of anxiety disorders in children and adolescents.
Year(s) Of Engagement Activity 2013,2014
 
Description 2 Day Workshop (Copenhagen University, 27-28/05/13) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact The workshop involved questions, discussion and practice of treatment techniques

Increased awareness and improved treatment of anxiety disorders in children and adolescents
Year(s) Of Engagement Activity 2013
 
Description 2 Day Workshop (OCTC, 10-11/06/13, 12-13/05/14, 19-20/10/15; 15-16/09/16) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact The workshop involved participants asking questions, discussion and practice of treatment techniques.

Increased awareness and improved identification and treatment of anxiety disorders in children and adolescents
Year(s) Of Engagement Activity 2013,2014,2015,2016
 
Description ADAA conference (Miami, 08-11/04/15) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on research to group of practitioners and postgrad students. Questions and discussion followed.
Year(s) Of Engagement Activity 2015
 
Description BABCP Annual Conference (Leeds, 27/07/12, London, 18/07/13, Birmingham, 23/07/14, Warwick 22-25/07/15) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation paper presentation
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on research to group of practitioners and postgraduate students, involving questions and discussion.

Increased awareness among attendees of specific issues relating to anxiety in adolescence
Year(s) Of Engagement Activity 2013,2014,2015
 
Description BHFT Health Research Conference: Research Collaborations for Better Patient Care 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact 50-100 conference delegates attended the conference, which led to questions and discussion around possible further research collaborations.
Year(s) Of Engagement Activity 2018
 
Description Berkshire West Mental Health Support Teams School Development Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Berkshire West Mental Health Support Teams School Development Day, November 2019; Keynote speaker. Led to questions and discussion.
Year(s) Of Engagement Activity 2019
 
Description CAMHS conference (University of Northampton 02/07/14) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk sparked question and discussion afterwards

Increased knowledge of treatment interventions and adolescent/parent treatment satisfaction for adolescents with an anxiety disorder.
Year(s) Of Engagement Activity 2014
 
Description CATTS seminar (Amsterdam, 09/09/14) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Discussion with colleagues

Future collaborations discussed and planned
Year(s) Of Engagement Activity 2014
 
Description EABCT Annual Conference (Marrakech, 27/09/13; Stockholm, 2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation paper presentation
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk led to discussion and questions afterwards.

Increased awareness among attendees of specific issues relating to anxiety in adolescence.
Year(s) Of Engagement Activity 2013,2016
 
Description Emotional Literacy Support Assistants (ELSA) Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Emotional Literacy Support Assistants (ELSA) Conference, Windsor, June 2019; Keynote speaker. Led to questions and discussion.
Year(s) Of Engagement Activity 2019
 
Description Half-day Workshop (Bath Uni DClinPsy, 20/12/12, 13/12/13, 17/04/15) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Workshop sparked questions, discussion and allowed practice of treatment techniques

Increased awareness and improved identification and treatment of anxiety disorders in children and adolescents. Afterwards trainees got in touch about doing a placement in our clinic.
Year(s) Of Engagement Activity 2012,2013,2015
 
Description I led the organisation of and co-chaired an evening of workshops and a conference on 'Evidence-based Mental Health in Schools' in September 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact The conference brought together several high-profile experts from various disciplines and the event was aimed at key authority figures in schools, policy makers and researchers. There were around 300 delegates on the day. The conference brought together several high-profile experts from various disciplines and the event was aimed at key authority figures in schools, policy makers and researchers. It was live-streamed and reached an international audience, with over 17 million impressions on twitter.
Year(s) Of Engagement Activity 2017
 
Description International Association for Adolescent Health European Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 22nd International Association for Adolescent Health European Conference, organised by the UK Royal College of Paediatrics and Child Health (RCPCH) and the US Society for Adolescent Health and Medicine (SAHM), Ascot, September 2019; Keynote speaker. Led to questions and discussion.
Year(s) Of Engagement Activity 2019
 
Description Interview with BBC News Online (07/11/14) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Piece on BBC Website led to discussion in social media, e.g. twitter, on relevant health websites and among charities/user groups

Piece on BBC News Online was ranked the most popular article for 'health', 'education' and 'regional', was 'shared' from the BBC website 2,200 times and the link was tweeted/re-tweeted to approx. 20,000 people. A number of individuals have got in touch to request further information, via twitter and email following the piece.
Year(s) Of Engagement Activity 2014
 
Description Interview with BBC Radio Berkshire (10/11/14) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Interview was played in news bulletins throughout afternoon and evening, listened to by more than 100,000 people.

Since then people have got in touch to ask for more information
Year(s) Of Engagement Activity 2014
 
Description NIHR Blogs 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Two blogs on NIHR website on research project and findings.
Year(s) Of Engagement Activity 2015
 
Description Parent group workshop (PoCAD) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact I ran a 2-hour workshop for parents on 'supporting your child with anxiety', organised by a local organisation, the Parents of Children with Anxiety and Depression (PoCAD) Group, Reading, April 2019. This led to questions and discussion afterwards.
Year(s) Of Engagement Activity 2019
 
Description Personally asked as a invited speaker at IAPT Connect Conference (London, 2017) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 50 practitioners attended talk on using routine outcome measures and reported that they would change their practice
Year(s) Of Engagement Activity 2017
 
Description Personally asked as a keynote speaker at International Conference on Child and Adolescent Psychopathology (Roehampton, July 2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Gave presentation, followed by question and answer and discussion
Year(s) Of Engagement Activity 2016
 
Description Personally asked as an invited Speaker BPS CYF annual conference (Birmingham, 06/10/15) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on research to group of practitioners and postgrad students. Questions and discussion followed.
Year(s) Of Engagement Activity 2015
 
Description Personally asked as an invited speaker at ACAMH conference (Reading, 31/10/14) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk sparked question and discussion

Increased awareness and improved identification and treatment of anxiety disorders in adolescents
Year(s) Of Engagement Activity 2014
 
Description Personally asked to write an article for BACP Children and Young People Journal (March 2016) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Wrote review article on research project and findings.
Year(s) Of Engagement Activity 2016
 
Description Presentation at WCBCT, Melbourne (June 2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation to professional practitioners and postgraduate students, followed by question and answer session
Year(s) Of Engagement Activity 2016
 
Description Presentation to Psychology teachers (Leighton Park School, 12/02/13) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Talk led to questions and discussion and requests for further information.

School asked for clinic visit for sixth form pupil, who has now moved on to do a Psychology degree; teachers expressed interest in research and using some treatment approaches in their work with pupil
Year(s) Of Engagement Activity 2013
 
Description Public event (Mental Health Awareness Evening, 13/05/14; 10/06/15; 25/06/18) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Event aimed at parents and people who work with children and young people; (280 attendees). Presentations prompted extensive discussion. Parents and school staff provided excellent feedback.

Increased awareness of our research work
Year(s) Of Engagement Activity 2014,2015
 
Description Radio interview (Radio Verulam, 23/01/13) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact 20 minute interview on the Parent Show, which is broadcast regionally and then podcast is available internationally.

Increased awareness among members of the public of anxiety in childhood, ways that parents can help their child, resources and how to access professional help.
Year(s) Of Engagement Activity 2013
 
Description Radio interview for BBC Radio Berkshire 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact BBC Radio Berkshire - interview broadcast as part of news bulletins 14/12/17 (listenership - approx. 140,000)
Year(s) Of Engagement Activity 2017
 
Description School visit (Leweston school, 26/04/13) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Gave 3 20-minute presentations to pupils about clinical psychology and research, which led to questions and discussion

Teacher reported increase in pupils going on to do A-level Psychology, clinic visit by 2 pupils
Year(s) Of Engagement Activity 2013
 
Description TV Interview That's Thames Valley TV 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Interview for That's Thames Valley TV, freeview channel 7, YouTube
Year(s) Of Engagement Activity 2017
 
Description Teaching on child development course (BADCL, 08/02/13, 28/02/14) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Talk sparked questions and discussion

Increased awareness and improved identification of anxiety disorders in children and adolescents
Year(s) Of Engagement Activity 2013,2014
 
Description Top Tips for the Royal College of General Practitioners 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact I co-produced a set of Top Tips for the Royal College of General Practitioners, in collaboration with other clinical researchers, two GPs and a parent representative (2019) - not aware of what impact is has had at this point.
Year(s) Of Engagement Activity 2019
URL https://www.rcgp.org.uk/-/media/Files/CIRC/Toolkits-2017/Mental-Health-Toolkit-2017/2019-Documents/T...
 
Description Virtual Schools Event, Magdalen College Oxford, December 2019; Invited speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Virtual Schools Event, Magdalen College Oxford, December 2019; Invited speaker and Q&A panel member. Led to questions and discussion.
Year(s) Of Engagement Activity 2019
 
Description Workshop on dealing with adolescent anxiety in secondary schools at the Royal College of Psychiatrists/National Association of Head Teachers Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Around 20-30 teachers, psychiatrists and other professionals attended 2-hour workshop and reported at the end that this would led to changes in their professional practice.
Year(s) Of Engagement Activity 2018
 
Description World Congress of Behavioural and Cognitive Therapies (WCBCT), Berlin 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation to professional practitioners and postgraduate students, followed by question and answer session
Year(s) Of Engagement Activity 2019