A general conceptual and statistical framework to model non-linear and delayed exposure-response relationships and combi

Lead Research Organisation: London Sch of Hygiene and Trop Medicine
Department Name: Public Health and Policy

Abstract

Scientific studies which assess the health effects of various risk factors usually depend on statistical models, used to quantify the relationship between the dose people are exposed to, and the health outcome. This relationship should concisely and reliably summarize the association, in order to correctly inform about the health consequences of specific risk factors. This association is usually estimated in multiple comparable studies, whose evidence needs then to be combined in order to improve the knowledge about related health risks.

Researchers at the London School of Hygiene and Tropical Medicine, in collaboration with the MRC-Cambridge and the University of Southern California, have promoted a project to provide the statistical tools suitable to describe complex relationships and combine them across studies. These methodologies will be implemented in statistical software, freely available and usable by all the researchers working in different biomedical fields. The aim of the project is to improve the analytical method to study the association between risk factors and human health.

Technical Summary

Background

Epidemiological multi-city studies on the health effects of environmental factors, such as air pollution and temperature, have known an intense development in the last few years. Within this study design, two methodological issues are prominent among those that need to be addressed: how to specify exposure-response relationships describing potentially non-linear and delayed effects in each city, and how to combine such complex associations across different cities.
Interestingly, the same problems apply in different research areas involving different study designs and data structures. The extension and further development of statistical methodologies already proposed in time series analysis would provide a valuable tool in a wide range of research fields.

Purpose

The aim of this project is to develop a general conceptual and statistical framework to model non-linear and delayed exposure-response relationships, and to propose appropriate approaches to combine such complex associations across studies.

Specific objectives:
1. to define a general conceptual framework to formalize the idea of delayed effects.
2. to provide a unified statistical approach to model non-linear and delayed effects by extending existing methods developed in time series analysis.
3. to review, compare and extend meta-analytic techniques to synthesize non-linear and/or delayed associations.
4. to provide a complete software implementation of the methodologies described above in the R statistical software, together with detailed and comprehensive documentation.

Research plan

This research is comprised of sub-projects Sub-P1 and Sub-P2.
Sub-P1 addresses objectives 1-2-4. Existing methods in time series analysis, based on distributed lag non-linear models, will be improved and extended, algebraically and conceptually, to different designs such as cohort and longitudinal analysis. The framework will be implemented by extending the R package dlnm developed by the applicant.
Sub-P2 addresses objectives 3-4. In particular, two existing techniques, meta-smoothing and multivariate meta-analysis, will be compared and extended, assessing their flexibility, applicability, and reliability of their results through simulations and applications to real data. A specific R package will be developed to implement these models.

Collaborations

The research involves collaborations with high-calibre and experienced researchers across three different institutions (LSHTM, MRC-Cambridge and University of Southern California).

Research outputs

The research project aims to provide a unified methodological approach to model and pool non-linear and delayed dependencies, through a general conceptual and statistical framework. The research project emphasizes generality and usability, specifying a systematic and widely applicable methodology, which encompasses different study designs and data structures, and providing a comprehensive software implementation and documentation.

Publications

10 25 50
 
Description Temperature, climate change and health
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Use of DLNMs in temperature-health studies
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
URL http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/10kxh85C77hGm5PFkch6qfQ/
 
Title Personal website 
Description The website provides access to the outputs of my research, such as pdf versions and supplemental material of the published papers, summaries and updates of my research activity, and other information. In particular, scripts and data for reproducing the results of methodological or substantive papers are made available thorough the website. 
Type Of Material Improvements to research infrastructure 
Year Produced 2012 
Provided To Others? Yes  
Impact The website is visited by 5-10 visitors each day. They download materials such as articles, scripts and data. 
URL http://www.ag-myresearch.com/
 
Title R package dlnm 
Description The package contains functions and data examples for running distributed lag non-linear models. It is provided within the free software R and downloadable from internet through the R program. 
Type Of Material Improvements to research infrastructure 
Year Produced 2009 
Provided To Others? Yes  
Impact The software implementation in a free program has boosted the use of DLNMs among researchers in different countries, primarily (but not only) for studies on temperature and air pollution. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians. 
URL http://cran.r-project.org/web/packages/dlnm/index.html
 
Title R package mvmeta 
Description The package contains functions and data examples for running univariate or multivariate meta-analysis and meta-regression. It is provided within the free software R and downloadable from internet through the R program. 
Type Of Material Improvements to research infrastructure 
Year Produced 2011 
Provided To Others? Yes  
Impact The software implementation in a free program facilitates the use of multivariate meta-analytical techniques in the research community. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians. 
URL http://cran.r-project.org/web/packages/mvmeta/index.html
 
Title Distributed lag non-linear models 
Description Flexible modelling technique for describing the temporal pattern of linear or non-linear exposure-response associations, termed exposure-lag-response associations. 
Type Of Material Data analysis technique 
Year Produced 2009 
Provided To Others? Yes  
Impact Huge impact on research on the health effects of temperature and other risk factors, certified by the use of the technique in several peer-reviewed articles by different research groups: http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/10kxh85C77hGm5PFkch6qfQ/ 
 
Title Multivariate meta-analysis 
Description Application of multivariate-meta-analysis to pool complex associations defined by multiple parameters 
Type Of Material Data analysis technique 
Year Produced 2012 
Provided To Others? Yes  
Impact Impact on applications of meta-analysis approaches, certified by the use of the technique in several peer-reviewed articles by different research groups: http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1bE6r3sM055G4oxSb_eqi8o/ 
 
Title Personal website 
Description The website provides access to the outputs of my research, such as pdf versions and supplemental material of the published papers, summaries and updates of my research activity, and other information. In particular, scripts and data for reproducing the results of methodological or substantive papers are made available thorough the website. 
Type Of Material Database/Collection of data 
Year Produced 2012 
Provided To Others? Yes  
Impact The website is visited by 5-10 visitors each day. They download materials such as articles, scripts and data. 
URL http://www.ag-myresearch.com/
 
Title R package dlnm 
Description The package contains functions and data examples for running distributed lag non-linear models. It is provided within the free software R and downloadable from internet through the R program. 
Type Of Material Computer model/algorithm 
Year Produced 2009 
Provided To Others? Yes  
Impact The software implementation in a free program has boosted the use of DLNMs among researchers in different countries, primarily (but not only) for studies on temperature and air pollution. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians. Huge impact on research on the health effects of temperature and other risk factors, certified by the use of the technique in several peer-reviewed articles by different research groups: http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1bE6r3sM055G4oxSb_eqi8o/ 
URL http://cran.r-project.org/web/packages/dlnm/index.html
 
Title R package mvmeta 
Description The package contains functions and data examples for running univariate or multivariate meta-analysis and meta-regression. It is provided within the free software R and downloadable from internet through the R program. 
Type Of Material Computer model/algorithm 
Year Produced 2011 
Provided To Others? Yes  
Impact The software implementation in a free program facilitates the use of multivariate meta-analytical techniques in the research community. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians. Impact on application of meta-analytical approaches, certified by the use of the technique in several peer-reviewed articles by different research groups: http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/10kxh85C77hGm5PFkch6qfQ/ 
URL http://cran.r-project.org/web/packages/mvmeta/index.html
 
Description Modelling health effects of environmental exposures 
Organisation Children's Hospital of Philadelphia
Department Center for Pediatric Clinical Effectiveness
Country United States 
Sector Hospitals 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Modelling health effects of environmental exposures 
Organisation Columbia University
Department Department of Environmental Health Sciences
Country United States 
Sector Academic/University 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Modelling health effects of environmental exposures 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Modelling health effects of environmental exposures 
Organisation Public Health Agency of Canada
Department Canada Prenatal Nutrition Program
Country Canada 
Sector Public 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Modelling health effects of environmental exposures 
Organisation University of Hasselt
Department Centre for Environmental Sciences
Country Belgium 
Sector Academic/University 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Modelling health effects of environmental exposures 
Organisation University of Leuven
Department Department of Public Health and Primary Care
Country Belgium 
Sector Academic/University 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Modelling health effects of environmental exposures 
Organisation University of Ottawa
Country Canada 
Sector Academic/University 
PI Contribution Technical contribution on statistical methods and software programs, intellectual contribution to publications
Collaborator Contribution Leading the development of the methodological research, leading on writing up of peer-review publications
Impact Peer-reviewed publications in international journals and oral presentations in international congresses
Start Year 2012
 
Description Multi-country analysis of temperature effects 
Organisation Fudan University
Country China 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Lazio Regional Health Service
Country Italy 
Sector Public 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Nagasaki University
Country Japan 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation National Taiwan University
Country Taiwan, Province of China 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Queensland University of Technology (QUT)
Country Australia 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Seoul National University
Country Korea, Republic of 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Spanish National Research Council (CSIC)
Country European Union (EU) 
Sector Public 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation Umea University
Country Sweden 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation University of Ottawa
Country Canada 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation University of Queensland
Country Australia 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation University of Sao Paulo
Country Brazil 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description Multi-country analysis of temperature effects 
Organisation University of Tsukuba
Country Japan 
Sector Academic/University 
PI Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact Peer-reviewed publications, oral contributions and workshops in international congresses
Start Year 2013
 
Description PHASE project 
Organisation Center for Research in Environmental Epidemiology
Country Spain 
Sector Academic/University 
PI Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact One peer-reviewed article: de' Donato FK, Leone M, Scortichini M, De Sario M, Katsouyanni K, Lanki T, Basagana X, Ballester F, Astrom C, Paldy A, Pascal M, Gasparrini A, Menne B, Michelozzi M. Changes in the effect of heat on mortality in the last 20 years in nine European cities. Results from the PHASE project. International Journal of Environmental Research and Public Health. 2015;12(12):15567-15583. Oral contributions in international conferences: Scortichini M, de'Donato F, Astrom DO, Basagana X, Gasparrini A, Iniguez C, Katsouyanni K, Lanki T, Paldy A, Pascal M, Michelozzi P, Analitis A. An annual comparison of the effects of summer temperatures on mortality for 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014. de'Donato F, Leone M, Analitis A, Paldy A, Lanki T, Gasparrini A, Pascal M, Astrom C, Ballester F, Basagana X, Michelozzi P. Temporal variations in the effect heat and cold, by age group and cause of death in 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014.
Start Year 2012
 
Description PHASE project 
Organisation Lazio Regional Health Service
Country Italy 
Sector Public 
PI Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact One peer-reviewed article: de' Donato FK, Leone M, Scortichini M, De Sario M, Katsouyanni K, Lanki T, Basagana X, Ballester F, Astrom C, Paldy A, Pascal M, Gasparrini A, Menne B, Michelozzi M. Changes in the effect of heat on mortality in the last 20 years in nine European cities. Results from the PHASE project. International Journal of Environmental Research and Public Health. 2015;12(12):15567-15583. Oral contributions in international conferences: Scortichini M, de'Donato F, Astrom DO, Basagana X, Gasparrini A, Iniguez C, Katsouyanni K, Lanki T, Paldy A, Pascal M, Michelozzi P, Analitis A. An annual comparison of the effects of summer temperatures on mortality for 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014. de'Donato F, Leone M, Analitis A, Paldy A, Lanki T, Gasparrini A, Pascal M, Astrom C, Ballester F, Basagana X, Michelozzi P. Temporal variations in the effect heat and cold, by age group and cause of death in 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014.
Start Year 2012
 
Description PHASE project 
Organisation National and Kapodistrian University of Athens
Country Greece 
Sector Academic/University 
PI Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact One peer-reviewed article: de' Donato FK, Leone M, Scortichini M, De Sario M, Katsouyanni K, Lanki T, Basagana X, Ballester F, Astrom C, Paldy A, Pascal M, Gasparrini A, Menne B, Michelozzi M. Changes in the effect of heat on mortality in the last 20 years in nine European cities. Results from the PHASE project. International Journal of Environmental Research and Public Health. 2015;12(12):15567-15583. Oral contributions in international conferences: Scortichini M, de'Donato F, Astrom DO, Basagana X, Gasparrini A, Iniguez C, Katsouyanni K, Lanki T, Paldy A, Pascal M, Michelozzi P, Analitis A. An annual comparison of the effects of summer temperatures on mortality for 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014. de'Donato F, Leone M, Analitis A, Paldy A, Lanki T, Gasparrini A, Pascal M, Astrom C, Ballester F, Basagana X, Michelozzi P. Temporal variations in the effect heat and cold, by age group and cause of death in 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014.
Start Year 2012
 
Description PHASE project 
Organisation Sorbonne University
Country France 
Sector Academic/University 
PI Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact One peer-reviewed article: de' Donato FK, Leone M, Scortichini M, De Sario M, Katsouyanni K, Lanki T, Basagana X, Ballester F, Astrom C, Paldy A, Pascal M, Gasparrini A, Menne B, Michelozzi M. Changes in the effect of heat on mortality in the last 20 years in nine European cities. Results from the PHASE project. International Journal of Environmental Research and Public Health. 2015;12(12):15567-15583. Oral contributions in international conferences: Scortichini M, de'Donato F, Astrom DO, Basagana X, Gasparrini A, Iniguez C, Katsouyanni K, Lanki T, Paldy A, Pascal M, Michelozzi P, Analitis A. An annual comparison of the effects of summer temperatures on mortality for 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014. de'Donato F, Leone M, Analitis A, Paldy A, Lanki T, Gasparrini A, Pascal M, Astrom C, Ballester F, Basagana X, Michelozzi P. Temporal variations in the effect heat and cold, by age group and cause of death in 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014.
Start Year 2012
 
Description PHASE project 
Organisation Umea University
Country Sweden 
Sector Academic/University 
PI Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact One peer-reviewed article: de' Donato FK, Leone M, Scortichini M, De Sario M, Katsouyanni K, Lanki T, Basagana X, Ballester F, Astrom C, Paldy A, Pascal M, Gasparrini A, Menne B, Michelozzi M. Changes in the effect of heat on mortality in the last 20 years in nine European cities. Results from the PHASE project. International Journal of Environmental Research and Public Health. 2015;12(12):15567-15583. Oral contributions in international conferences: Scortichini M, de'Donato F, Astrom DO, Basagana X, Gasparrini A, Iniguez C, Katsouyanni K, Lanki T, Paldy A, Pascal M, Michelozzi P, Analitis A. An annual comparison of the effects of summer temperatures on mortality for 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014. de'Donato F, Leone M, Analitis A, Paldy A, Lanki T, Gasparrini A, Pascal M, Astrom C, Ballester F, Basagana X, Michelozzi P. Temporal variations in the effect heat and cold, by age group and cause of death in 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014.
Start Year 2012
 
Description PHASE project 
Organisation University of Valencia
Country Spain 
Sector Academic/University 
PI Contribution Contributed to the definition of the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Collaborator Contribution Leading the collaborative project; formalized the collaboration; defined the collaboration format, the research directions and research outcomes; leading or contribution on specific sub-projects
Impact One peer-reviewed article: de' Donato FK, Leone M, Scortichini M, De Sario M, Katsouyanni K, Lanki T, Basagana X, Ballester F, Astrom C, Paldy A, Pascal M, Gasparrini A, Menne B, Michelozzi M. Changes in the effect of heat on mortality in the last 20 years in nine European cities. Results from the PHASE project. International Journal of Environmental Research and Public Health. 2015;12(12):15567-15583. Oral contributions in international conferences: Scortichini M, de'Donato F, Astrom DO, Basagana X, Gasparrini A, Iniguez C, Katsouyanni K, Lanki T, Paldy A, Pascal M, Michelozzi P, Analitis A. An annual comparison of the effects of summer temperatures on mortality for 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014. de'Donato F, Leone M, Analitis A, Paldy A, Lanki T, Gasparrini A, Pascal M, Astrom C, Ballester F, Basagana X, Michelozzi P. Temporal variations in the effect heat and cold, by age group and cause of death in 9 European cities. International Society for Environmental Epidemiology (ISEE) Conference - Seattle, 24-28 August 2014.
Start Year 2012
 
Title R package dlnm 
Description The package contains functions and data examples for running distributed lag non-linear models. The software is freely downloadable by everybody, and it is licensed under the GNU General Public License, meaning that, under appropriate reference and the assurance that novel material is provided under the same licence terms, it can be modified and extended by other researchers. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2009
Licensed Yes
Impact The software implementation in a free program has boosted the use of DLNMs among researchers in different countries, primarily (but not only) for studies on temperature and air pollution. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians.
 
Title R package mvmeta 
Description The package contains functions and data examples for running univariate or multivariate meta-analysis and meta-regression. The software is freely downloadable by everybody, and it is licensed under the GNU General Public License, meaning that, under appropriate reference and the assurance that novel material is provided under the same licence terms, it can be modified and extended by other researchers. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2011
Licensed Yes
Impact The software implementation in a free program facilitates the use of multivariate meta-analytical techniques in the research community. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians.
 
Title R package dlnm 
Description The package contains functions and data examples for running distributed lag non-linear models. It is provided within the free software R and downloadable from internet through the R program. 
Type Of Technology Software 
Year Produced 2009 
Open Source License? Yes  
Impact The software implementation in a free program has boosted the use of DLNMs among researchers in different countries, primarily (but not only) for studies on temperature and air pollution. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians. 
URL http://cran.r-project.org/web/packages/dlnm/index.html
 
Title R package mvmeta 
Description The package contains functions and data examples for running univariate or multivariate meta-analysis and meta-regression. It is provided within the free software R and downloadable from internet through the R program. 
Type Of Technology Software 
Year Produced 2011 
Open Source License? Yes  
Impact The software implementation in a free program facilitates the use of multivariate meta-analytical techniques in the research community. Also, the package, developed in parallel with the statistical framework, offer a vehicle to promote the methodology and its use among non-statisticians. 
URL http://cran.r-project.org/web/packages/mvmeta/index.html
 
Description Centre for Statistical Modelling (CSM) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact I am a member of the Steering Committee. I am the coordinator of two themes Time-series regression analysis and Statistical Computing within the CSM. These roles involves organizing activities and seminars on a regular basis.

Seminars and other activities are usually attended by 50-100 researchers, PhD or MSc students
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015
URL http://csm.lshtm.ac.uk/
 
Description Invited talks 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Series of invited talks and workshops in well-known research institutions, such as Harvard School of Public Health, Karolinska Institute, Royal Statistical Society, The Children Hospital of Philadelphia, Centre for Research in Environmental Epidemiology (CREAL), University of Pennsylvania, Ludwig Maximilians University, Swiss Tropical and Public Health Institute, Open University, St George's University of London
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014