Do steroid transporters regulate the effects of glucocorticoid hormones on the brain - in cells, in animals and humans?

Lead Research Organisation: King's College London
Department Name: Unlisted

Abstract

Major depression is the most prevalent of all psychiatric disorders and the single most burdensome disease in the world among people in the middle years of life. Moreover, currently available antidepressant treatments are effective in only 50-70 % of patients, and research into antidepressants has not yet identified a definitive biochemical system that is responsible for the clinical effects of these drugs. Recent studies have suggested that one possible biological mechanism involved in depression is the abnormal effect of glucocorticoid hormones, like cortisol, on the brain. Moreover, our own research has shown that antidepressant treatment may regulate the effects of cortisol on the brain.

The aim of this study is to examine, both in the laboratory and in a clinical setting, the physiology of the glucocorticoid action on the brain and the mechanisms behind its regulation by antidepressants. Therefore, this project will improve our knowledge of the causes of major depression and will lead to the development of new ideas for a better treatment, which will be the ultimate implementation of our research findings into clinical practice.

Technical Summary

My hypothesis is that membrane steroid transporters, on the blood-brain-barrier (BBB) and in neurones, regulate the effects of the glucocorticoids on brain function and are a target of antidepressant treatment.

My recent work has demonstrated that membrane steroid transporters, like the multidrug resistance (MDR) P-glycoprotein (Pgp), regulate the intracellular levels of glucocorticoids in fibroblasts and neurones. Moreover, I have shown that the transport of glucocorticoids across cell membranes in vitro, and across the BBB in guinea-pigs, occurs at physiological concentrations of hormones. Finally, I have found that antidepressants inhibit these transporters (Pariante et al. 2001a, 2001b, 2003a; 2003b, 2004).

In the course of this 5-year project, I will study the membrane transport of glucocorticoids and its inhibition by antidepressants.

In vitro: I will study the mechanisms of steroid membrane transport, and of its inhibition by antidepressants, using techniques assessing the function and the expression of these transporters in mouse fibroblasts, rat cortical neurones, and epithelial cells that have been used as in vitro models of the human BBB.

In animals: I will study the transport of cortisol and corticosterone into the brain and cerebrospinal fluid (CSF) of mice (FBV mice that are knockout for MDR1a and MDR1b Pgp genes, and FVB/Ntac control mice). Moreover, I will examine the effects of 21-day treatment with the antidepressants, clomipramine and citalopram, on the transport of glucocorticoids.

In humans: I will investigate the access of cortisol and corticosterone to the brain, and its regulation by citalopram, in healthy volunteers, using a cognitive task (executive function) together with event-related potential (ERP) recordings.

The in vitro work (at the Institute of Psychiatry) will be conducted with Professor R. Kerwin, Dr A. Makoff and Professor S. Lovestone. The animal experiments will take place in the laboratories of Dr S. Thomas, at Guy‘s, King‘s and St Thomas‘ School of Biosciences, and of Professor S. Lightman and Dr H. Reul, in the Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology at the University of Bristol. The research in humans will be conducted at the University of Newcastle, with Dr H. McAllister-Williams. Conclusions:

Publications

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Aiello G (2013) Citizen, interrupted: the 2011 English riots from a psychosocial perspective. in Epidemiology and psychiatric sciences

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Alboni S (2013) N-acetyl-cysteine prevents toxic oxidative effects induced by IFN-a in human neurons. in The international journal of neuropsychopharmacology

 
Title For all sad words 
Description Developed in collaboration with Prof Carmine Pariante, this work is a metaphorical blood exchange. It draws from Prof Pariante's research at King's College on blood inflammation in patients with depression, Stanford University's studies that show transfusion of young blood in old mice reversed aging, and Lund University's proposition that a protein found in beetroot (incidentally an anti-inflammatory food) could substitute human blood. The artist, Lynn Lu, invited participants to tell her about a significant personal regret. Then she pricked their finger and place a drop of blood in a petri dish. In exchange, she offers them a shot of anti-inflammatory beet juice. Over the weekend, the petri dishes fill with blood "inflamed" with lament, while vials of detoxifying beetroot empty one by one. 
Type Of Art Performance (Music, Dance, Drama, etc) 
Year Produced 2017 
Impact Engagement with the Science Gallery and other artistic organisation interested in using art to disseminate science 
URL https://lynnlu.info/for-of-all-sad-words-of-tongue-and-pen-the-saddest-are-these-it-might-have-been/...
 
Title Recording for live performance of artist Lynn Lu 
Description Drawing deeply from her personal experience, the artist Lynn Lu has spent some time during the development process of a performance for the CCLAP Festival with Professor Carmine Pariante, and his team at King's College London. Their research has found a clear link between mothers with postnatal depression not adequately nurturing their children and these children in time becoming themselves mothers who suffer from postnatal depression. At Deptford Lounge, the artist will create a safe space, one that she would have liked to have had, as a mother with postnatal depression. This safe space is offered to all mothers, as well as for anyone who might need an experience of nurturing. Together the artist and participants will put in words their darkest thoughts and feelings that have not been voiced. The anonymous texts will then be sealed in palm-sized clay envelops, and fired for strength / privacy / resilience. These accumulating tablets will be exhibited throughout the week. Participants will be invited to be cocooned and rocked in a wide fabric hammock for as long as they wish - as if in the womb, or a rockabye baby. In doing so, they will listen to a RECORDING OF THE INTERVIEW BETWEEN PROFESSOR PARIANTE AND THE ARTIST, which has been digitally modified so to make the words unintelligeble and similar to relaxing music. This performance will take place at Deptford Lounge. Full schedule for CCLAP 2015. 
Type Of Art Performance (Music, Dance, Drama, etc) 
Year Produced 2015 
Impact The recording was used in the performance, as above, so was publicly used. 
URL http://cclap.me/2015/10/26/cclap-2015-lynn-lu-the-hand-that-rocks-the-cradle/
 
Description 2013 CMO Report on Mental Health - Chapter on Neuroscience
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Improved understanding of neuroscience issues relevant to mental health
 
Description BAP Antidepressant Guideliness
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
Impact Improvement of prescription practice
 
Description British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017.
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Decisions about the use of psychotropic medication in pregnancy are an ongoing challenge for clinicians and women with mental health problems, owing to the uncertainties around risks of the illness itself to mother and fetus/infant, effectiveness of medications in pregnancy and risks to the fetus/infant from in utero exposure or via breast milk. These consensus guidelines aim to provide pragmatic advice regarding these issues. They are divided into sections on risks of untreated illness in pregnancy; general principles of using drugs in the perinatal period; benefits and harms associated with individual drugs; and recommendations for the management of specific disorders.
URL http://journals.sagepub.com/doi/pdf/10.1177/0269881117699361
 
Description AMBROSIAC - A Menu for Brain Responses Opposing Stress-Induced Alterations in Cognition
Amount £169,306 (GBP)
Funding ID MR/N029488/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 08/2018
 
Description APIRE award
Amount £24,000 (GBP)
Organisation American Psychiatric Institute for Research and Education 
Sector Charity/Non Profit
Country United States
Start 01/2007 
End 01/2009
 
Description BA Project Grant
Amount £100,000 (GBP)
Organisation The British Academy 
Sector Academic/University
Country United Kingdom
Start 01/2007 
End 01/2010
 
Description Biomedical Research Centre - Affective Disorder and Interface with Medicine Theme
Amount £50,000,000 (GBP)
Funding ID NIHR Biomedical Research Centre at the South London and Maudsley NHS Trust and King's College London 
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description Distinguished Investigator Award
Amount $100,000 (USD)
Organisation Brain & Behaviour Research Foundation 
Sector Charity/Non Profit
Country United States
Start 07/2018 
End 06/2019
 
Description EC FP7 Collaborative Project Grant (Agreement n°22963 (Mood Inflame))
Amount £484,000 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 01/2008 
End 01/2012
 
Description ECNP Young Researcher Grant/European College of Neuropsychopharmacology (ECNP) Studenstships
Amount £80,000 (GBP)
Organisation European College of Neuropsychopharmacology (ECNP) 
Sector Learned Society
Country European Union (EU)
Start 01/2009 
End 01/2011
 
Description FSID Project Grant
Amount £50,000 (GBP)
Organisation The Lullaby Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2010 
End 01/2011
 
Description Jannsen Investigator Initiated
Amount £680,000 (GBP)
Organisation Johnson & Johnson 
Department Janssen Pharmaceuticals
Sector Private
Country United States
Start 01/2013 
End 12/2017
 
Description King's College Development Trust Studentship
Amount £63,000 (GBP)
Organisation King's College London 
Sector Academic/University
Country United Kingdom
Start 01/2006 
End 01/2009
 
Description MRC Immunopsychiatry consortium
Amount £200,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2014 
End 09/2016
 
Description MRC Research Grant (Eurostress)
Amount £66,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2009 
End 01/2012
 
Description Marie Curie
Amount £180,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2013 
End 03/2015
 
Description NARSAD Young and Intermediate Investigator Awards
Amount £310,000 (GBP)
Organisation Autism Speaks 
Sector Charity/Non Profit
Country United States
Start 01/2006 
End 01/2011
 
Description NIHR Senior Investigator
Amount £45,000 (GBP)
Funding ID NF-SI-0616-10074 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2020
 
Description Persistent Fatigue Induced by Interferon-alpha: A New Immunological Model for Chronic Fatigue Syndrome
Amount £373,075 (GBP)
Funding ID MR/J002739/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 08/2012 
End 08/2016
 
Description Post-doctorate fellowship to Martin Egeland to study inflammation and neurogenesis in rodents
Amount £182,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 05/2013 
End 04/2015
 
Description South London and Maudsley NHS Foundation Trust & Institute of Psychiatry NIHR Biomedical Research Centre for Mental Health
Amount £250,000 (GBP)
Organisation South London and Maudsley (SLAM) NHS Foundation Trust 
Department NIHR Maudsley Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 01/2007 
End 01/2012
 
Description To investigate inflammation-related cellular models of depression
Amount £680,000 (GBP)
Organisation Johnson & Johnson 
Department Janssen Pharmaceutica
Sector Private
Country Global
Start 11/2013 
End 12/2016
 
Description Understanding the role of gender, inflammation and sex hormones in the prevention and treatment of affective disorders Psychiatry Research Trust
Amount £83,444 (GBP)
Funding ID Psychiatry Research Trust 
Organisation King's College London 
Department Psychiatry Research Trust
Sector Charity/Non Profit
Country United Kingdom
Start 10/2018 
End 09/2021
 
Description Wellcome Project grant
Amount £447,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2009 
End 01/2013
 
Description Wellcome Trust Neuroimmunology Consortium
Amount £1,100,000 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Institutional Strategic Support Fund
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 12/2019
 
Title Depression in a dish model 
Description We have used human neuronal stem cells and human neurones derived from iPSC cells and treated with a host of depressogenic stimuli (cortisol, Il-1, Il-6, interferon-alpha, oxidative stress) and antidepressant strategies (SSRIs, tricyclics, omega-3, anti-inflammatories). This model replicates well established brain cellular phenotypes associated with depression (or, conversely, antidepressant treatment) such as change sin neurogenesis and synaptogenesis, as well as changes in molecular mechanisms that can be replicated in the brain of animal subjected to stress/antidepressants as well as in clinical samples of depressed patients. 1: Egeland M, Zunszain PA, Pariante CM. Molecular mechanisms in the regulation of adult neurogenesis during stress. Nat Rev Neurosci. 2015 Apr;16(4):189-200. doi: 10.1038/nrn3855. Review. PubMed PMID: 25790864. 2: Horowitz MA, Wertz J, Zhu D, Cattaneo A, Musaelyan K, Nikkheslat N, Thuret S, Pariante CM, Zunszain PA. Antidepressant compounds can be both pro- and anti-inflammatory in human hippocampal cells. Int J Neuropsychopharmacol. 2014 Oct 31;18(3). pii: pyu076. doi: 10.1093/ijnp/pyu076. PubMed PMID: 25522414; PubMed Central PMCID: PMC4360247. 3: Anacker C, Cattaneo A, Musaelyan K, Zunszain PA, Horowitz M, Molteni R, Luoni A, Calabrese F, Tansey K, Gennarelli M, Thuret S, Price J, Uher R, Riva MA, Pariante CM. Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8708-13. doi: 10.1073/pnas.1300886110. Epub 2013 May 6. PubMed PMID: 23650397; PubMed Central PMCID: PMC3666742. 4: Anacker C, Cattaneo A, Luoni A, Musaelyan K, Zunszain PA, Milanesi E, Rybka J, Berry A, Cirulli F, Thuret S, Price J, Riva MA, Gennarelli M, Pariante CM. Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis. Neuropsychopharmacology. 2013 Apr;38(5):872-83. doi: 10.1038/npp.2012.253. Epub 2012 Dec 6. PubMed PMID: 23303060; PubMed Central PMCID: PMC3672002. 5: Zunszain PA, Anacker C, Cattaneo A, Choudhury S, Musaelyan K, Myint AM, Thuret S, Price J, Pariante CM. Interleukin-1ß: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis. Neuropsychopharmacology. 2012 Mar;37(4):939-49. doi: 10.1038/npp.2011.277. Epub 2011 Nov 9. PubMed PMID: 22071871; PubMed Central PMCID: PMC3280640. 6: Anacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S, Price J, Pariante CM. Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol Psychiatry. 2011 Jul;16(7):738-50. doi: 10.1038/mp.2011.26. Epub 2011 Apr 12. PubMed PMID: 21483429; PubMed Central PMCID: PMC3121947. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2015 
Provided To Others? Yes  
Impact Development of a platform for the potential development of novel antidepressants, with reduction in required use of animals. 
URL http://www.pnas.org/content/110/21/8708.long
 
Description Department of Psychiatry and Mind-Body Interface Research Centre, China Medical University Hospital, Taichung, Taiwan 
Organisation China Medical University Hospital
Department Department of Psychiatry and Mind-Body Interface Research Centre
Country Taiwan, Province of China 
Sector Hospitals 
PI Contribution Exchange visit between Dr. Su (Taiwan) and Dr. Pariante
Collaborator Contribution Research collaboration with Dr. Su
Impact Many publications have arisen from this collaboration, built on work conducted both in London and in Taiwan: PMID: 18370571; 17888811; 17591516; 17503999; 17070845; 17017838; 20034614.
Start Year 2006
 
Description Department of Psychiatry, Newcastle University, UK 
Organisation Newcastle University
Department Academic Psychiatry and Regional Affective Disorders Service
Country United Kingdom 
Sector Academic/University 
PI Contribution A study was conducted on EEG and cortisol in the collaborator's laboratory; the study was funded by this grant and was in the original research proposal.
Collaborator Contribution Collaboration with Dr. H. McAllister-Williams for a clinical study on EEG.
Impact The study has been completed and a publication is currently in preparation.
Start Year 2008
 
Description Erasmus University, Rotterdam 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Exchange of researchers and data
Collaborator Contribution Training in laboratory expertise and exchange of data
Impact Papers and new grant applications.
Start Year 2008
 
Description Janssen Pharmaceuticals 
Organisation Johnson & Johnson
Department Janssen Pharmaceuticals
Country United States 
Sector Private 
PI Contribution A joint academic-pharma collaboration that has brought approximately £680,000 in research funding
Collaborator Contribution Shared academic leadership and full funding of research programma
Impact - a fully funded research programme on depression and inflammation - additional grant applications to MRC and the Wellcome
Start Year 2012
 
Description MRC Immunopsychiatry Consortium 
Organisation GlaxoSmithKline (GSK)
Department Psychiatry (GSK)
Country United Kingdom 
Sector Private 
PI Contribution Design of studies, execution of studies and experiments
Collaborator Contribution Funding of studies, contribution to research strategy and design
Impact Data exchange, publications (in preparation)
Start Year 2014
 
Description MRC Immunopsychiatry Consortium 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Design of studies, execution of studies and experiments
Collaborator Contribution Funding of studies, contribution to research strategy and design
Impact Data exchange, publications (in preparation)
Start Year 2014
 
Description MRC Social Genetic and Developmental Psychiatry Centre (SDGP 
Organisation King's College London
Department MRC Social Genetic and Developmental Psychiatry Centre (SDGP)
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration with Dr. Aitchison and Professors Moffitt and Caspi.
Collaborator Contribution Development of a parallel clinical and pre-clinical research strategy linked with the current proposal.
Impact PMID 19751968, 19074533, 18458677, 19996051, 18391129, 17229839, 20157309
Start Year 2006
 
Description Pharmaceutical Science Research Division, Kings College London (KCL), UK 
Organisation King's College London
Department School of Medicine KCL
Country United Kingdom 
Sector Academic/University 
PI Contribution The experiments on blood-brain barrier permeability have been conducted in the collaborator's laboratory but funded by this grant.
Collaborator Contribution Collaboration with Dr. Sarah Thomas in joint supervision of a PhD student and conducting animal studies.
Impact PMID: 18556350, 17356567, 20881247
 
Description Queen's Medical Research Institute, University of Edinburgh, UK 
Organisation University of Edinburgh
Department Queen's Medical Research Institute Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution I have been in Edinburgh several times to plan the experiments with the collaborators. The collaborators have funded and conducted the study
Collaborator Contribution Collaboration with Professor Seckl in an animal study
Impact PMID: 17356567
Start Year 2006
 
Description Royal College of Surgeons in Ireland 
Organisation Royal College of Surgeons in Ireland
Department Department of Psychiatry
Country Ireland 
Sector Academic/University 
PI Contribution Scientific collaboration on in vitro models relevant to the present project
Collaborator Contribution Collaboration on in vitro models based on present grant
Impact PMID: 18562437, 17938637
 
Description University of Bristol 
Organisation University of Bristol
Department School of Clinical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution We have planned together animal and human research funded by this grant.
Collaborator Contribution Scientific collaboration with Professor Stafford Lightman
Impact PMID 19336786, 18675469, 17356567, 17016711, 20558006
 
Description Wellcome Trust Neuroimmunology Consortium 
Organisation H. Lundbeck A/S
Department Neuroscience; Lundbeck
Country Denmark 
Sector Private 
PI Contribution A research consortium; we recruit and select patients and deliver research
Collaborator Contribution They participate to the research strategy
Impact Data collection, publications (all still in preparation), novel potential targets for antidepressants discovery
Start Year 2014
 
Description Wellcome Trust Neuroimmunology Consortium 
Organisation Johnson & Johnson
Country United States 
Sector Private 
PI Contribution A research consortium; we recruit and select patients and deliver research
Collaborator Contribution They participate to the research strategy
Impact Data collection, publications (all still in preparation), novel potential targets for antidepressants discovery
Start Year 2014
 
Description Wellcome Trust Neuroimmunology Consortium 
Organisation Pfizer Ltd
Country United Kingdom 
Sector Private 
PI Contribution A research consortium; we recruit and select patients and deliver research
Collaborator Contribution They participate to the research strategy
Impact Data collection, publications (all still in preparation), novel potential targets for antidepressants discovery
Start Year 2014
 
Description Wellcome Trust Neuroimmunology Consortium 
Organisation Wellcome Trust
Department Wellcome Trust Strategic Award
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution A research consortium; we recruit and select patients and deliver research
Collaborator Contribution They participate to the research strategy
Impact Data collection, publications (all still in preparation), novel potential targets for antidepressants discovery
Start Year 2014
 
Title Gene expression levels of inflammatory cytokines as predictor of antidepressant response 
Description Validation in a second sample now completed; publication in submission 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2016
Development Status Under active development/distribution
Impact Improve prediction of antidepressant response and personalised medicine 
 
Title Prednisolone suppression test 
Description A test to assess stress hormones secretion that predicts treatment response in depressed patients. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact The relevant paper have been published: 19336786, 17016711, 20558006. 
 
Description Antidepressants may not be perfect, but they DO save lives: Expert reveals how life-changing the drug can be when used in the right way 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Professor Carmine Pariante has treated thousands of patients with depression Despite expert claims the pills have devastating side-effects, he stands by them
They work when used correctly, especially alongside psychological therapy

Read more: http://www.dailymail.co.uk/health/article-4243156/Antidepressants-not-perfect-save-lives.html#ixzz4awYvDP2Q
Year(s) Of Engagement Activity 2017
URL http://www.dailymail.co.uk/health/article-4243156/Antidepressants-not-perfect-save-lives.html
 
Description Article for The Independent 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact An opinion piece defending the safe use of antidepressants. As a psychiatrist, I know that Johann Hari is wrong to cast doubt on antidepressants
Suggesting that prescribing antidepressants to a patient who suffers from clinical depression is the equivalent of treating them as a 'machine with malfunctioning parts' is wrong, unhelpful and even dangerous

Carmine Pariante Wednesday 10 January 2018 14:00 GMT
Year(s) Of Engagement Activity 2018
URL http://www.independent.co.uk/voices/johann-hari-depression-anti-depressants-psychiatrists-pills-ther...
 
Description Blog on the Huffington Post 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A regular blog entry that I have on the Huffington Post on topics of mental health
Year(s) Of Engagement Activity 2012,2015,2016,2017
URL http://www.huffingtonpost.co.uk/author/carmine-pariante
 
Description Cheltenham Science festival 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Many questions and subsequent emails

I was reached by journalists for further interviews
Year(s) Of Engagement Activity 2012
 
Description Daily Mail 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview of perinatal depression

Attracted public interest
Year(s) Of Engagement Activity 2010
 
Description Inspire the Mind - a new online publication on mental health 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact InSPIre the Mind is new online publication on the Medium Platform, directed by Carmine Pariante. It will bring the point of view of a group of clinicians and researchers working in mental health. In this new publication, we want to complement people's accounts by discussing the clinical and the scientific evidence underpinning these personal experiences, while also sharing with the readers our research, our clinical work, and or our cultural and societal considerations. We are the members of the Stress, Psychiatry and Immunology (SPI) Lab at the Institute of Psychiatry, Psychology and Neuroscience, at King' College London, and these are our stories.
Year(s) Of Engagement Activity 2019
URL https://medium.com/inspire-the-mind
 
Description Interview for BBC Radio 4 Programme 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact BBC health reporter James Gallagher explores the increasing body of evidence that a dysfunctional immune system is responsible for the depression or psychotic illness experienced by hundreds of thousands, perhaps millions, of people in the UK. James talks to the psychiatrists investigating this new understanding of mental illness and to people who may benefit from treatments aimed at the immune systems rather than their brain cells.

"I believe this is one of the strongest discoveries in psychiatry in the last twenty years", says Professor Carmine Pariante of his and other research on the immune system and depression. "It allows us to understand depression no longer as just a disorder of the mind and not even a disorder of the brain, but a disorder of the whole body. It shifts conceptually what we understand about depression."

James also talks to New York journalist Susannah Cahalan. She began to experience paranoid delusions and florid hallucinations when her immune system made damaging antibodies against part of the molecular circuitry in her brain. Treatment to eliminate the antibodies prevented her committal to psychiatric hospital. Psychiatrist Professor Belinda Lennox at the University of Oxford says she has evidence that a significant proportion of people presenting for the first time with psychotic symptoms are victims of a similar autoimmune problem.

Producer: Rachael Buchanan and Andrew Luck-Baker.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/b07pj2pw
 
Description Personal blog on the Huffington Post 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact regular entry blogs on topics related to mental health
Year(s) Of Engagement Activity 2015,2016
URL http://www.huffingtonpost.co.uk/carmine-pariante/
 
Description Plenary Lecture at the Conference of Forensic Psychiatry of the Royal College of Psychiatrists 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A plenary lecture on my research on depression and inflammation
Year(s) Of Engagement Activity 2017
 
Description Plenary Lecture at the Italian Society for Psychopathology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A plenary lecture on my research on depression and the immune system
Year(s) Of Engagement Activity 2017
 
Description Press conference 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Press conference associated with a symposium on depression

Private interviews with a radio, description on news websites
Year(s) Of Engagement Activity 2009
 
Description Symposium at the Royal College of Psychiatrists 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact S33 Predicting response to antidepressants: Is it possible? Wednesday 1st of July 2015
Chair: Dr Hamish McAllister-Williams, Newcastle University

HPA axis and inflammatory cytokines *Professor Carmine Pariante, Institute of Psychiatry, London

Cognition and emotional processing Professor Catherine Harmer, University of Oxford EEG variables
Dr Hamish McAllister-Williams, Newcastle University


S54 Inflammation & Mental Health: An overview of perinatal and later life infection/inflammation on risk for common mental illnesses - - Thursday 2nd of July
Chair: Prof Hugo Critchley, Brighton & Sussex Medical School

Early-life infection alters glial function and increases susceptibility to cognitive and neuropsychiatric disorders including schizophrenia and
autism
Dr Staci Bilbo, Duke University

Can blood and brain MRI biomarkers be used to identify patients most likely to benefit from 'anti-inflammatory' treatments?
Dr Neil Harrison, University of Sussex

Update on the current evidence supporting a role for 'anti-inflammatory' agents in the management of treatment resistant depression *Professor Carmine Pariante, Kings College London
Year(s) Of Engagement Activity 2015
 
Description Visit of HRH The Duchess of Cambridge to Professor Pariante's laboratory 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Duchess of Cambridge visits King's College London's IoPPN and the Mother and Baby Unit at Bethlem Royal Hospital

The Duchess of Cambridge visited Professor Pariante's laboratory at the Maurice Wohl Clinical Neuroscience Institute at King's College London to find out more about the Institute of Psychiatry, Psychology & Neuroscience's (IoPPN) pioneering 'bench to bedside' mental health research and to meet leading scientists in the area. The Duchess continued to the Mother and Baby Unit, Royal Bethlem Hospital, South London and Maudsley NHS Foundation Trust, to meet clinicians and patients.
Year(s) Of Engagement Activity 2018
URL https://www.kcl.ac.uk/ioppn/news/records/2018/january/duchess-of-cambridge-visits-kings-college-lond...