Generic and hormonal determinants of male reproductive health and fertility

Lead Research Organisation: University of Edinburgh
Department Name: School of Clinical Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description BBSRC Project Grant
Amount £795,000 (GBP)
Funding ID BB/J015105/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 07/2012 
End 06/2015
 
Description British Heart Foundation Project Grant
Amount £298,015 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2012 
End 06/2015
 
Description British Heart Foundation Project Grant
Amount £98,018 (GBP)
Funding ID PG/07/105 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2008 
End 03/2010
 
Description Early Career Grants Programme (Dr Laura O'Hara)
Amount £9,980 (GBP)
Organisation Society for Endocrinology 
Sector Learned Society
Country United Kingdom
Start 11/2012 
End 10/2013
 
Description MRC Programme Grant
Amount £2,087,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2011 
End 10/2016
 
Description Michelson Project Grant
Amount $609,000 (USD)
Funding ID D1011-S05 
Organisation Found Animals Foundation 
Sector Charity/Non Profit
Country United States
Start 02/2013 
End 08/2015
 
Description Tenovus Scotland
Amount £10,000 (GBP)
Organisation Tenovus 
Department Tenovus Scotland
Sector Charity/Non Profit
Country United Kingdom
Start 04/2008 
End 04/2009
 
Description Vacation Scholarship
Amount £1,841 (GBP)
Funding ID Vac-707-2013 
Organisation Medical Research Scotland 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2013 
End 09/2013
 
Title Cre Recombinase Lentivirus 
Description We developed a lentivius contained a Cre Recombinase transgene. This permits use of the cre/lox system upon viral infection 
Type Of Material Technology assay or reagent 
Year Produced 2011 
Provided To Others? Yes  
Impact Manuscript in Preparation 
 
Title Cyp11a1-Cre mouse line 
Description we developed a mouse line expressing Cre Recombinase form the Cyp11a1 promoter - has utility for targeting floxed alleles in steroidogenic tissues 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2014 
Provided To Others? Yes  
Impact Defined sites of expression and targeted Androgen Receptor. Mouse deposited at the Jackson Laboratory and made freely available to others 
 
Title mouse model of vascular Ehlers Danlos Syndrome 
Description We developed a mouse model of vascular Ehlers Danlos Syndrome - a mutation in Col3a1 no other mouse model of this condition exists. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2011 
Provided To Others? Yes  
Impact Paper published in Cardiovascular Research 
 
Title mouse models of AR ablation 
Description Several mouse models of perturbed testosterone action 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2011 
Provided To Others? Yes  
Impact INititation of a collaborative project with the Beatson Institute Glasgow 
 
Description Androgens in the cardiovascular system 
Organisation University of Edinburgh
Department Centre for Cardiovascular Science
Country United Kingdom 
Sector Academic/University 
PI Contribution Lee Smith initiated the project and acted as Principal Investigator on a successful grant application to te British Heart Foundation, producing all of the mouse models and pilot data to support the application
Collaborator Contribution Intellectual contributionon how I could apply my unique models of AR ablation to the cardiovascular system
Impact Project ongoing
Start Year 2011
 
Description Genetic analysis of a novel aortic dissection mouse model 
Organisation University of Edinburgh
Department Centre for Cardiovascular Science
Country United Kingdom 
Sector Academic/University 
PI Contribution I wrote the Home Offfice project licence to permit breeding of the mice. I wrote the grant applicaiton which was funded by the BHF, and supervised the Postdoctoral scientist on the project.
Collaborator Contribution Provided cardiovascular physiology expertise to complement the genetic analysis i undertook
Impact Production of a novel animal model that is being taken forward for potential licencing by MRC-T.
Start Year 2008
 
Description Somatic cell androgen receptor knock outs 
Organisation Catholic University of Louvain
Country Belgium 
Sector Academic/University 
PI Contribution We have imported mice from Belgium and produced a series of AR knockout models in collaboration with Professor Verhoeven's group
Collaborator Contribution Professor Verhoeven's group have collaborated with us in producing and analysing several testis somatic cell androgen receptor knockouts.
Impact 19392831, 19587329, 16166195.
 
Description Vascular Androgen receptor knockouts 
Organisation University of Edinburgh
Department Centre for Cardiovascular Science
Country United Kingdom 
Sector Academic/University 
PI Contribution I wrote the grant application and designed the experiments.
Collaborator Contribution Obtained an external grant from Tenovus Scotland to generate and conduct preliminary characterisation of vascular AR knockout mouse lines.
Impact Strengthening of intra-institute collaborations, generation of novel models for future exploitation into the role of androgens in cardiovascular disease risk
Start Year 2007
 
Description Public lecture - University of Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 200 members of the public attended a lecture I gave on development of novel non-hormonal male contraceptives. This led to a 30 minute question and answer session.

Uptake in an ongoing clinical study was increased
Year(s) Of Engagement Activity 2010
 
Description Talk: Androgens and Male Fertility 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact Talk given to animal facility staff as part of their continuing education/training

Improved dialogue with support staff regarding needs of the project. Reduction/refinement of animal usage.
Year(s) Of Engagement Activity 2007
 
Description Talk: Cell selective ablation of androgen receptors 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Talk at Institute Inter Centres meeting - audience included wide range of scientists many of whom were not working on reproduction

Collaborations with colleagues interested in the impact of androgens on the cardiovascular system
Year(s) Of Engagement Activity 2007
 
Description Twitter account @MaleFertilityUK 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact My group now has over 200 followers

approached by members of the public for further information
Year(s) Of Engagement Activity 2011
 
Description public lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Public lecture on the importance of testosterone in men, 100+ audience of general public, plus publishing of video of talk on youtube to reacha wider audience
Year(s) Of Engagement Activity 2016