Impact of sex steroids on immune and vascular cell function in the reproductive system

Lead Research Organisation: University of Edinburgh
Department Name: School of Clinical Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Young VJ (2013) The role of the peritoneum in the pathogenesis of endometriosis. in Human reproduction update

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Thiruchelvam U (2013) The importance of the macrophage within the human endometrium. in Journal of leukocyte biology

 
Description Academy of Medical Sciences Careers Committee
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Endometriosis - James Lind PSP
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact Management group of priority setting partnership in endometriosis run under the auspices of the James Lind Alliance. Financial support provided as part of public engagement commitment from grants. Surveys were conducted nationally and results led to publication of a top 10 priority for research - this is being considered by funders including NIHR (phone calls and discussions). High profile publication in the Lancet. Social media activity and engagement with clinical and research community.
 
Description Asset Sharing Scheme
Amount £302,097 (GBP)
Funding ID MR/P00265X/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 12/2019
 
Description CRUK Edinburgh Centre Award
Amount £170,000 (GBP)
Organisation Cancer Research UK 
Department Edinburgh Cancer Research UK Centre
Sector Academic/University
Country United Kingdom
Start 09/2014 
End 08/2017
 
Description Developmental Clinical Studies
Amount £1,600,000 (GBP)
Funding ID MR/J003611/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 12/2012 
End 12/2016
 
Description MOMENDO
Amount € 1,000,000 (EUR)
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 07/2016 
End 07/2019
 
Description MRC Career Development Award (Erin Greaves)
Amount £900,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2015 
End 12/2020
 
Description MRC Development Clinical Studies
Amount £1,423,676 (GBP)
Funding ID MR/J003611/1 
Organisation Medical Research Council (MRC) 
Department MRC Clinical Sciences Centre (CSC)
Sector Academic/University
Country United Kingdom
Start  
 
Description Multiuser Equipment Grant
Amount £793,450 (GBP)
Funding ID 202794/Z/16/Z 
Organisation Wellcome Trust 
Department Wellcome Trust Bloomsbury Centre
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 09/2021
 
Description PhD studentship - Tissue Repair
Amount £67,700 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2015 
End 09/2018
 
Description Programme Grant
Amount £1,818,379 (GBP)
Funding ID MR/N024524/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 03/2021
 
Description QMRI FACS facility core funding
Amount £550,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description QMRI Mass Spectometry Facility
Amount £739,245 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Research Project Grant
Amount £144,337 (GBP)
Funding ID R42533 
Organisation Wellbeing of Women 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2012 
End 12/2014
 
Description Research Project Grant
Amount £125,788 (GBP)
Funding ID MR/L002647/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2013 
End 12/2015
 
Title Novel mouse model of endometriosis 
Description Model uses 'menstrual' uterine tissue injected into mouse peritoneum - lesions formed phenocopy those in patients. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2014 
Provided To Others? Yes  
Impact Inclusion of model in grant applications (Fellowship for Greaves, Grant for Australian collaborators); interest from Pharma with promise of funding 
URL http://www.ncbi.nlm.nih.gov/pubmed/24910298
 
Description Studies on Endometriosis 
Organisation Catholic University of Louvain
Country Belgium 
Sector Academic/University 
PI Contribution Academic collaboration sharing ideas for publications and so-supervision of PhD student
Collaborator Contribution Academic collaboration sharing ideas for publications and so-supervision of PhD student
Impact Publications Grant for PhD student
Start Year 2012
 
Description Studies on endometriosis associated pain 
Organisation Charité - University of Medicine Berlin
Country Germany 
Sector Academic/University 
PI Contribution Training of visiting PhD student; dissemination of animal model of endometriosis
Collaborator Contribution Provision of human patient samples; PhD student time
Impact Training of PhD student; invitation to give a talk in Berlin for postdoc; publication
Start Year 2013
 
Company Name Ichtus 
Description Spin out from our work on Endometriosis - set up to conduct small clinical trials related to use of fish oils to control pain 
Year Established 2013 
Impact None yet
 
Description Androgens 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Title of talk: 'Endometrial health and disease; impact of androgens'

Opportunity to interact with peers.

Raised profile internationally.
Year(s) Of Engagement Activity 2014
 
Description Departmental Seminar, Geissen Germany 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Title of Talk: Androgens: master regulators of male health

Opportunity to network with peers. Increase profile.
Year(s) Of Engagement Activity 2014
 
Description Departmental Seminar, Geissen, Germany 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Kolloquium, Des Hessischen Zentrums fur Reproduktionsmedizin (HZRM), 12th February 2014.

Title of Talk: 'Androgens - master regulators of male heath'



Opportunity to network with peers. Raise profile.
Year(s) Of Engagement Activity 2014
URL http://www.med.uni-giessen.de/hzrm
 
Description Edinburgh Science Festival, April 2014 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Chaired Talks at Edinburgh Science Festival in April 2014.

Edinburgh Science Festivals are held every year and are well attended by the public. Raises public awareness of reproductive health.

Raised profile. Excellent feedback from public.
Year(s) Of Engagement Activity 2014
 
Description Endometriosis Patient Awareness Day 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Opportunity for members of the public to share and contribute to discussions.

Good feedback from members of the public.
Year(s) Of Engagement Activity 2014
 
Description International Competition for Sixth form students sponsored by MRC and Pfizer 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Schools
Results and Impact Interaction with school pupils - raised awareness of reproductive health.

Raised profile. Media coverage and good feedback from schools, MRC and Pfizer.
Year(s) Of Engagement Activity 2009,2010,2011,2012
 
Description Manchester University 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Invited to give talk entitled 'Human endometrium: mechanisms of steroid dependent receptivity, scarless repair and malignancy'.
Year(s) Of Engagement Activity 2015
 
Description Public Talk, Edinburgh Science Festival 2012 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Title of talk 'Sex,steroids: bodies, babies and brains'. Edinburgh Science Festival. 2011. Wide media coverage.

Raised my profile and public awareness of reproductive science. Excellent feedback.
Year(s) Of Engagement Activity 2012
 
Description Research Methodology Course 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other audiences
Results and Impact The Research Methodology course took place at South Hall, Pollock Halls Campus, Edinburgh from 27-28 February 2014.

The title of my talk was 'How to write the perfect grant proposal'.

Allowed good networking/discussion with other colleagues in the field.

The Research Methodology Course is held every year.

The course is aimed at practitioners at all levels from all disciplines (including medical, allied health professionals, nursing and midwifery staff, and scientists) who have an interest in or are actively engaged in clinical research.

The course allows for interactive lectures and opportunities for delegates to network with distinguished researchers, all of whom are recognised experts in their field.
Year(s) Of Engagement Activity 2014
URL http://www.ecat.ed.ac.uk/research-methods/
 
Description San Diego USA Satelite Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Society for Gynecological Investigation Endometrial Satelite Meeting. Title of talk: 'Androgens and endometrial function - a role in regulation of endometrial bleeding?' 2012.

Opportunity to interact with other researchers at international level.
Year(s) Of Engagement Activity 2012
 
Description Satellite Meeting World Congress of Endometriosis, San Paulo Brazil 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Satellite meeting, World Congress of Endometriosis, San Paulo Brazil - 30th April - 3rd May 2014.

Opportunity to network on an international level with peers. Raise profile.
Year(s) Of Engagement Activity 2014
URL http://www.allcongress.com/congress/12th-world-congress-on-endometriosis-wce-2014/
 
Description Satellite meeting World Congress Reproduction 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Title of talk: Androgens and women's Health - new insights.

Opportunity to network.
Year(s) Of Engagement Activity 2014
 
Description Science Competition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact PhD Student (Gemma Sharp) won 'I'm a scientist get me out of here'.

Widely publicised on line and in both MRC and University of Edinburgh publications/websites
Year(s) Of Engagement Activity 2011
 
Description Uppsala University - Public Talk 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact Invited to give public talk on 'Introduction to Viva'.

Title of Talk 'Sex hormones, production, action and impact'
Year(s) Of Engagement Activity 2015