BRAIN UK: accessing NHS tissue archives for neuroscience research
Lead Research Organisation:
University of Southampton
Department Name: Clinical Neurological Sciences
Abstract
The brain (and associated components including the spinal cord, nerves, muscle and eye) is important to us, essentially making us humans and giving us our identity and self awareness. It is composed of cells which, once formed in infancy, have to last us a lifetime. Inevitably, the brain is complex and may malfunction. Damage to, or disease of, any part of the nervous system is likely to result in physical disability, mental illness or may cause death. Study of brain tissue samples retained at post mortem examinations has led to many of the advances in our understanding of neurological disease in the last few decades, and led to new treatments. Animal models of human brain diseases have been helpful, but have the disadvantage that they are not the actual human disease itself, and therefore have in some instances been misleading. Work performed in the NHS by neuropathologists over the past 30-40 years across the UK, and which continues, has led to very substantial collections of stored brain tissue samples. The objective of BRAIN UK is to catalogue these samples and address ethical and legal issues, in order to allow release of appropriate samples for new research studies. The stream-lined application/review process and generic ethical approval has removed many of the bureaucratic hurdles until recently hindering researchers. Researchers can now access tissue for their studies from more than 60,000 cases through BRAIN UK. The ultimate aim, of course, is to further improve our understanding of the mechanisms involved in the development of neurological disease and eventually provide new forms of treatment or prevention for diseases of the nervous system.
Technical Summary
BRAIN UK is a virtual brain bank providing access to human tissue from more than 60,000 cases held in 13 NHS regional neuroscience centres across the UK. All ethical and NHS R&D permissions have been granted for blanket use of this tissue for researchers in the UK and overseas, so saving researchers considerable time and effort by removing these bureaucratic barriers to the use of human tissue. Many substantial advances in the understanding of neurological diseases have been made over the past decades from direct observations made on post mortem human tissue and further advances are to be anticipated. Animal models of disease have an important role, but also have their limitations. Types of tissue encompassed by BRAIN UK are the brain and associated components including the spinal cord, nerves, muscle, eye and samples of other organs when relevant to neurological disease. BRAIN UK is not limited to diseases that can attract sufficient funding for dedicated brain banks and is therefore complementary to them. For example, BRAIN UK has many hundreds of cases of head injury, stroke and mental health disorders and also examples of many rare conditions such as Progressive multifocal leucoencephalopathy and Neuromyelitis optica. The work in collecting, processing, categorising and archiving the samples has already been performed within the NHS; in providing a mechanism for access to this tissue for research BRAIN UK provides exceptional added value. With this proposal for continued funding for BRAIN UK we aim to: continue providing access to tissue for researchers, further refine the database for greater precision in access to information and put into place a mechanism to permit inclusion of new cases obtained now and into the future.
Organisations
- University of Southampton, United Kingdom (Lead Research Organisation)
- South Tees Hospitals NHS Foundation Trust, Middlesbrough (Collaboration)
- North Bristol NHS Trust, United Kingdom (Collaboration)
- University Hospitals Birmingham NHS Foundation Trust, Birmingham (Collaboration)
- Plymouth Hospitals NHS Trust (Collaboration)
- King's College University Hospital NHS Trust (Collaboration)
- Imperial College Healthcare NHS Trust (Collaboration)
- Great Ormond Street Hospital (GOSH) (Collaboration)
- Barking, Havering and Redbridge University Hospitals NHS Trust (Collaboration)
- Royal Free London NHS Foundation Trust, United Kingdom (Collaboration)
- Leeds Teaching Hospitals NHS Trust, United Kingdom (Collaboration)
- NHS Lothian, United Kingdom (Collaboration)
- Cardiff & Vale University Health Board, United Kingdom (Collaboration)
- Cambridge University Hospitals, Cambridge (Collaboration)
- Oxford University Hospitals NHS Trust, United Kingdom (Collaboration)
- Nottingham University Hospitals NHS Trust, Nottingham (Collaboration)
- Barts Health NHS Trust, London (Collaboration)
- NHS Greater Glasgow and Clyde (NHSGGC) (Collaboration)
- Salford Royal NHS Foundation Trust, Greater Manchester (Collaboration)
- Medical Research Council (Collaboration)
- University Hospital Southampton NHS Foundation Trust, Southampton (Collaboration)
- University College London Hospital (UCLH) NHS Foundation Trust (Collaboration)
- St George's Healthcare NHS Trust (Collaboration)
- The Walton Centre NHS Foundation Trust, Fazakerley (Collaboration)
- Lancashire Teaching Hospitals NHS Foundation Trust (Collaboration)
- Hull and East Yorkshire Hospitals NHS Trust (Collaboration)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (Collaboration)
- Sheffield Teaching Hospitals NHS Foundation Trust (Collaboration)
People |
ORCID iD |
| James Nicoll (Principal Investigator) | |
| David Hilton (Co-Investigator) |
Publications
Mitchell C
(2015)
PO81A LACK OF CONSENT TO DONATE BRAIN TUMOUR TISSUE FOR RESEARCH HAMPERS PROGRESS
in Neuro-Oncology
| Description | Brain UK biopsy extension |
| Amount | £90,000 (GBP) |
| Funding ID | 512921101 |
| Organisation | Brainstrust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2013 |
| End | 07/2016 |
| Description | Bridging funding from "Brain Tumour Research" |
| Amount | £27,031 (GBP) |
| Organisation | Brain Tumour Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 09/2017 |
| Title | BRAIN UK Database |
| Description | The construction of a linked anonymised electronic database containing details of the archival tissue holdings of UK neuropathology centres to form a virtual brain bank consisting of: ? Diagnostic category ? Diagnostic code (SNOMED CT or equivalent) ? Laboratory/Post Mortem Number ? Tissue format ? Age at death ? Age at operation ? Sex ? Geographical location |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Provided the project with a searchable dataset able to support applications for access to tissue. So far has supported 82 projects (2010 - 2016). |
| URL | http://www.southampton.ac.uk/brainuk/about/index.page? |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Barking, Havering and Redbridge University Hospitals NHS Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Barts Health NHS Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Cambridge University Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Cardiff and Vale University Health Board |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Great Ormond Street Hospital (GOSH) |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Hull and East Yorkshire Hospitals NHS Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Imperial College Healthcare NHS Trust |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | King's College University Hospital NHS Trust |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Lancashire Teaching Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Leeds Teaching Hospitals NHS Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | NHS Greater Glasgow and Clyde (NHSGGC) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | NHS Lothian |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Newcastle upon Tyne Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | North Bristol NHS Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Nottingham University Hospitals NHS Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Oxford University Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Plymouth Hospitals NHS Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Royal Free London NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Salford Royal NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Sheffield Teaching Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | South Tees Hospitals NHS Foundation Trust |
| Department | Department of Cellular Pathology |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | Southampton University Hospitals NHS Trust (SUHT) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | St George's Healthcare NHS Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | The Walton Centre NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | University College London Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | BRAIN UK network of participating neuropathology centres |
| Organisation | University Hospitals Birmingham NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Formation of BRAIN UK |
| Collaborator Contribution | Collaboration to provide data about archives and to satisfy requests for tissue. Supplying of tissue to ethically approved studies. |
| Impact | Formation of BRAIN UK database. Provision of brain tissue for research. Supported 82 projects, 29 of which have produced 52 platform presentations, 49 posters, 24 publications and 18 grants (generating over £1,300,000 income). Around 90 interactions or collaborations generated by applicants and Participating Centres working within the BRAIN UK network. |
| Start Year | 2008 |
| Description | MRC UK Brain Banks Network |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | BRAIN UK compliments the tissue that the other brain banks within the MRC network provide. BRAIN UK (through data supplied by the participating neuropathology centres) have identified very useful quantities of rare neurological diseases and disorders as well as larger quantities of common and medically important disorders (such as stroke) and tumours that are currently not catered for by existing brain banking facilities. Participation at meetings and training events ensures that BRAIN UK's experiences of working with researchers are represented and that the brain banks work towards common aims. |
| Collaborator Contribution | By 2015 BRAIN UK collaborating centres contributed data relating to over 130,000 available research cases to the centralised BRAIN UK database. |
| Impact | No formal outcomes. |
| Start Year | 2009 |
| Description | Annual report to the BRAIN UK Committee |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Annual meeting of BRAIN UK committee. Metrics data supplied to members to give an insight into how study is progressing, intention is to provide a support and challenge environment. As the study and the format of the meeting is well established good level of discussion around direction of the study with supportive suggestions for future direction and practical offers of support. |
| Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014 |
| Description | Annual report to the British Neuropathological Society |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Brief update delivered to the British Neuropathological Society Business Meeting as part of their annual meeting. Main aim is to keep the Neuropathology community aware of the work of BRAIN UK with the intention to keep receiving their support through the supply of data and tissue and for them to recommend the service to researchers. Also, to maintain engagement with neuropathologists and researchers and ensure that we are meeting their current and future needs. |
| Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014 |
| Description | BRAIN UK biopsy extension press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | BRAIN UK biopsy extension press release published on some trust websites and local news papers such as the Daily Echo in Southampton. |
| Year(s) Of Engagement Activity | 2014 |
| Description | BRAIN UK, the National Brain Tumour Bank Network Three Years On; Oncology News, Vol 11, Issue 5, Nov/Dec 2016. ISSN 1751-4975 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Article published highlighting achievements of the first three years of the study's extension to include surgical material. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://issuu.com/oncologynews/docs/011116 |
| Description | Development of BRAIN UK website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Improvements to BRAIN UK website - including improvements, extensions and new sections to website and creation of BRAIN UK branding. Aim was to give BRAIN UK a web presence, provide information to different stakeholders in the project and improve the efficiency of transfer of information. |
| Year(s) Of Engagement Activity | 2015,2016,2017 |
| URL | http://www.brain-uk.org |
| Description | Interview promoting the launch of BRAIN UK biopsy extension on JACK FM |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Radio interview promoting the launch of the BRAIN UK biopsy extension on Jack FM. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Interview promoting the launch of BRAIN UK biopsy extension on Wave 105 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Radio interview promoting the launch of the BRAIN UK biopsy extension on Wave 105. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Linkage from British Neuroscience Association (BNA) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | URL link established from ABN website (http://www.bna.org.uk/about/related-links.html) to BRAIN UK and dissemination of information in ABN e-Newsletter January 2012. |
| Year(s) Of Engagement Activity | 2012 |
| URL | http://www.bna.org.uk/about/related-links.html |
| Description | Linkage from MRC Brain Banks Network website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Link from the MRC Brain Banks Network http://www.mrc.ac.uk/research/facilities/brain-banks/access-for-research/ to promote the usage of BRAIN UK. |
| Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014 |
| URL | http://www.mrc.ac.uk/research/facilities/brain-banks/access-for-research/ |
| Description | Platform presentation to British Neuro-Oncology Society Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Platform presentation to describe the biopsy extension to conference participants to raise awareness and support for project. Questions and discussion afterwards and two enquiries for applications for tissues and additional centre request to participate in the project. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Platform presetation to British Neuro-Oncology Society Conference (Leeds) 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Platform presentation to describe the progress made with the biopsy extension to conference participants to raise awareness and support for project. Questions and discussion afterwards and enquiries for applications for tissues |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bnos.org.uk/wp-content/uploads/2015/06/BNOS-2016-Conference-Report.pdf |
| Description | Platform presetation to British Neuropathological Society Conference (London) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Platform presentation to describe the latest activities of BRAIN UK to conference participants to raise awareness and support for project. Questions and discussion afterwards and enquiries for applications for tissues. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://onlinelibrary.wiley.com/doi/10.1111/nan.2016.42.issue-S1/issuetoc |
| Description | Poster at British Neuropathological Society (London) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster to describe BRAIN UK to conference participants to raise awareness and support for project. Questions and discussion afterwards and enquiries for applications for tissues |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://onlinelibrary.wiley.com/doi/10.1111/nan.2015.41.issue-S1/issuetoc |
| Description | Poster at Society for Neuro-Oncology Conference on Meningioma ( June 17-18, 2016 in Toronto, Ontario, Canada) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Interest in BRAIN UK |
| Year(s) Of Engagement Activity | 2016 |
| Description | Poster at Southampton Neuroscience Group (SoNG) Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Poster to promote BRAIN UK project locally |
| Year(s) Of Engagement Activity | 2014,2015 |
| Description | Presentation to National Cancer Research Institute Brain Tumour Clinical Studies Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Describe the biopsy extension to National Cancer Research Institute Brain Tumour Clinical Studies Group to raise awareness and support for project. Questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Presentation to National Cancer Research Institute Brain Tumour Clinical Studies Group 'Hot Topics and New Directions' Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Describe the biopsy extension to National Cancer Research Institute Brain Tumour Clinical Studies Group organised meeting, mostly to wide group of neuro-oncologists and neurologists, to raise awareness and support for project, raise awareness of the issues around consent to research. Questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Promotion of Corsellis Collection for "All in the Mind" on Radio 4 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Involvement with making of an "All in the Mind" Radio 4 programme , highlighting the closure the Corsellis Collection and the benefits of brain banking and research on human tissue. This resulted in further press interest and funding opportunities. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.bbc.co.uk/programmes/b06r5d0h |
| Description | Raise awareness of BRAIN UK with the CCLG |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Raise awareness of BRAIN UK activities with the Children's Cancer and Leukaemia Group Biological Studies Steering Group. Discussion on how can work together and how BRAIN UK fits with other brain banks. |
| Year(s) Of Engagement Activity | 2014 |