Improving outcome from hypertensive disorders of pregnancy: a programme of clinical trials and epidemiological studies

Lead Research Organisation: University of Oxford
Department Name: RDM Clinical Laboratory Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Abalos E (2018) Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. in The Cochrane database of systematic reviews

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Abalos E (2007) Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. in The Cochrane database of systematic reviews

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Churchill D (2013) Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. in The Cochrane database of systematic reviews

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Duley L (2010) Magnesium sulphate versus diazepam for eclampsia. in The Cochrane database of systematic reviews

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Duley L (2010) Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. in The Cochrane database of systematic reviews

 
Guideline Title Hypertension in pregnancy
Description Citation in Cochrane review
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact Change in policy and practice for women with pre-eclampsia
 
Description Cochrane review
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
Impact Supports use of magnesium sulphate for pre-eclampsi and eclampsia
 
Guideline Title NICE Hypertension in Pregnancy
Description NICE
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact Reduction in eclampsia
URL http://www.nice.org.uk/CG107
 
Guideline Title RCOG greentop guideline, treatment for women with pre-eclampsia
Description citation to trial report, citation in Cochrane review
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact Contributing to reduction in maternal mortality and morbidity
 
Description Improving quality of care and outcome at very preterm birth
Amount £1,821,977 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2011 
End 02/2016
 
Description MRC Global Health Joint call
Amount £153,852 (GBP)
Funding ID MR/M017397/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 11/2014 
End 12/2016
 
Description MRC Methodology
Amount £300,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2009 
End 09/2012
 
Title Short ASQ 
Description Shortened version of the Ages and Stages Questionnaire 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2006 
Provided To Others? Yes  
Impact Publication of our experience with the short ASQ. 
 
Description AMICABLE 
Organisation University of Adelaide
Department Discipline of Obstetrics and Gynaecology
Country Australia 
Sector Academic/University 
PI Contribution Data for mothers and babies born before 32 weeks gestation
Collaborator Contribution Co-ordination of individual patient data meta-analysis
Impact Collaborators meeting to agree protocol, and results
Start Year 2010
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Assuit University Hospital, Egypt
Department Department of Obstetrics and Gynaecology
Country Egypt 
Sector Hospitals 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Bangabandhu Sheikh Mujib Medical University
Department Obstetrics and Gynaecology
Country Bangladesh 
Sector Academic/University 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Center for Perinatal Studies, Rosarino (CREP)
Country Argentina 
Sector Charity/Non Profit 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Chris Hani Baragwanath Hospital
Department Obstetrics and Gynaecology Baragwanath
Country South Africa 
Sector Hospitals 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Christian Medical College, Vellore
Department Obstetrics and Gynaecology Christian Medical College
Country India 
Sector Academic/University 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Fundacion Clinica Valle del Lili, Cali
Department Department of Obstetrics and Gynaecology
Country Colombia 
Sector Hospitals 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Harare Hospital
Department Obstetrics and Gynaecology Harare
Country Zimbabwe 
Sector Academic/University 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Hospital das Clinicas da UFPE
Department Department of Obstetrics and Gynaecology
Country Brazil 
Sector Hospitals 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Jinnah Hospital
Department Jinnah Postgraduate Medical Centre (JPMC)
Country Pakistan 
Sector Hospitals 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation KK Women and Childrens Hospital, Singapore
Department Obstetrics and Gynaecology KK Women and Childrens
Country Singapore 
Sector Hospitals 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation King Edward VIII Hospital, Durban
Country South Africa 
Sector Hospitals 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Komfo Anokye Teaching Hospital (KATH)
Department Obstetrics and Gynaecology Directorate KATH
Country Ghana 
Sector Hospitals 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Obstetrics and Gynaecology Princess Christian
Country Sierra Leone 
Sector Hospitals 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Oregon Health and Science University
Department Department of Obstetrics and Gynaecology
Country United States 
Sector Academic/University 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Royal Brisbane & Women's Hospital
Department Perinatal Research Centre Royal Brisbane
Country Australia 
Sector Academic/University 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation University Hospital of San Ignacio
Department Department of Obstetrics and Gynaecology
Country Colombia 
Sector Hospitals 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation University of Cambridge
Department Department of Obstetrics & Gynaecology
Country United Kingdom 
Sector Academic/University 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation University of Pretoria
Department Obstetrics and Gynaecology Pretoria
Country South Africa 
Sector Academic/University 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description Magpie Trial Follow up study Collaborative Group 
Organisation Women's and Children's Hospital Foundation
Country Australia 
Sector Charity/Non Profit 
PI Contribution Overall co-ordination, protocol development, trial materials, data management, analysis, writing up.
Collaborator Contribution Follow up of women and childrenCo-ordination of the follow up study in ArgentinaFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenFollow up of women and childrenCo-ordination of follow up in South AfricaFollow up of women and childrenFollow up of women and children
Impact Support for magnesium sulphate as drug of choice for eclampsia and pre-eclampsia. Use of magneisum sulphate has now been implemented across the UK, and is incorporated into national and international guidelines - including the RCOG and WHO.
 
Description PARIS collaborative group 
Organisation Medical Research Council (MRC)
Department MRC Clinical Trials Unit
Country United Kingdom 
Sector Public 
PI Contribution protocol development, project management, supervision
Collaborator Contribution co-ordination and support for a systematic reivew and IPD meta analysistechincal support technical and software support
Impact Lancet publication. Included in guidelines for prevention of pre-eclampsia, such as NICE
 
Description PARIS collaborative group 
Organisation The Cochrane Collaboration
Department UK Cochrane Centre
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution protocol development, project management, supervision
Collaborator Contribution co-ordination and support for a systematic reivew and IPD meta analysistechincal support technical and software support
Impact Lancet publication. Included in guidelines for prevention of pre-eclampsia, such as NICE
 
Description PARIS collaborative group 
Organisation University of Sydney
Department NSW Centre for Perinatal Health Services Research
Country Australia 
Sector Academic/University 
PI Contribution protocol development, project management, supervision
Collaborator Contribution co-ordination and support for a systematic reivew and IPD meta analysistechincal support technical and software support
Impact Lancet publication. Included in guidelines for prevention of pre-eclampsia, such as NICE
 
Title Magpie Trial - magnesium sulphate 
Description magnesium sulphate for prevention of eclampsia 
Type Therapeutic Intervention - Drug
Current Stage Of Development Late clinical evaluation
Development Status Closed
Clinical Trial? Yes
Impact Changed practice in the UK - now standard care. Also wide impact internationallly 
 
Description postal newsletter - results for participants 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Results of research sent to participants in Magpie Trial

Previous expereince is that women value this feedback
Year(s) Of Engagement Activity 2006