Functional roles of the novel guanine-nucleotide exchange factors P-Rex1 and P-Rex2.

Lead Research Organisation: Babraham Institute
Department Name: Dept of Development & Signalling

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Donald S (2008) P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. in Proceedings of the National Academy of Sciences of the United States of America

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Lissanu Deribe Y (2016) Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma. in Proceedings of the National Academy of Sciences of the United States of America

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Pitchford S (2017) Platelets in neutrophil recruitment to sites of inflammation. in Current opinion in hematology

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Welch H (2008) Role of GEFs in Disease in Targeted Protein Database

 
Description BBSRC Tenureship
Amount £1,000,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2008 
End 10/2017
 
Title Collection of P-Rex-deficient and control tissues. 
Description This is available to interested research groups, mainly for testing of panels of new P-Rex antibodies. 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2006 
Provided To Others? Yes  
Impact Better characterised research tools for the P-Rex research field. 
 
Title P-Rex deficient mouse strains 
Description P-Rex deficient mouse strains 
Type Of Material Technology assay or reagent 
Year Produced 2006 
Provided To Others? Yes  
Impact Two publications, several more submitted or currently in preparation, many more expected in the future. Discovery unsuspected roles of P-Rex in cancer metastasis and in motor control. 
 
Title Role of P-Rex in cancer metastasis 
Description Our P-Rex deficeint mice crossed with mouse models of cancer metastasis 
Type Of Material Model of mechanisms or symptoms - non-mammalian in vivo 
Year Produced 2006 
Provided To Others? Yes  
Impact Provides the field with the research tools to investigate a role for P-Rex in metastasis formation 
 
Title Role of P-Rex in motor coordination 
Description P-Rex deficient mice in behaviour testing and electrophysiological experiments showed that P-Rex controls motor coordination. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2007 
Provided To Others? Yes  
Impact Publication currently submitted, further collaborations envisaged. 
 
Description Role of P-Rex in metastasis 
Organisation Beatson Institute for Cancer Research
Country United Kingdom 
Sector Academic/University 
PI Contribution We provide mice, reagents, and assay know-how. We meet and are in contact regularly.
Collaborator Contribution Our collaborators are using our P-Rex-deficient mice, constructs and antibodies to test the role of P-Rex in cancer cell migration.
Impact A joint publication is currently submitted.
 
Description Role of P-Rex in synaptic plasticity 
Organisation Babraham Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution We provided genetically modified mouse strains with an intruiging phenotype, and a publication describing them that formed the basis of this collaboration.
Collaborator Contribution New avenue of research for our lab. Successful project. Joint manuscript submitted
Impact A joint manuscript has been published in 2010 in PLOS One.
Start Year 2007
 
Description Career Advice Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Lecture to Babraham Research Campus Post Docs on career in academic biosciences.

Improved communication between post docs, more senior researchers and the Institute's executive committee.
Year(s) Of Engagement Activity 2008
 
Description Career Advice Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Gave a lecture to Cambridge University PhD students and post docs on a career in bioscience at a Research Institute.

Answered many questions from the audience who never had the chance to experience work in a Research Institute as opposed to University.
Year(s) Of Engagement Activity 2009
 
Description Phagocytes.Net 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Participants in your research and patient groups
Results and Impact Revived a website for fellow phagocyte researchers that provides information on phagocyte-related events, research groups, and jobs. www.phagcytes.net

Better communication among research groups in the phagocyte field. Markedly increased numbers of participants at the annual meetings of the European Phagocyte Workshop.
Year(s) Of Engagement Activity 2008,2009
URL http://www.phagcytes.net
 
Description School visits in Cambridgeshire 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact Given lessons on "bones", provided animal bones and conducted "bones" practical.

Raised image of "the scientist" among scholl chidren in the area over the past years (questionnaires).
Year(s) Of Engagement Activity 2006,2008
 
Description Schools Days at Babraham 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact We host 10 GCSE or A level students for one day every year to conduct experiments.

Rasied image of "science" as a profession and of "scientists" among young people in the area.
Year(s) Of Engagement Activity 2006,2007,2008,2009