Investigation of the hypothalamic regulation of food intake, energy expenditure and body adiposity by neuropeptides

Lead Research Organisation: ICSTM at Hammersmith
Department Name: Medicine

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Alamshah A (2016) L-arginine promotes gut hormone release and reduces food intake in rodents. in Diabetes, obesity & metabolism

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Bloom S (2010) Control of appetite by gut hormones in Regulatory Peptides

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Bloom S (2010) Practical aspect of drug development in the peptide field in Regulatory Peptides

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Boughton CK (2010) Alarin stimulates food intake and gonadotrophin release in male rats. in British journal of pharmacology

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Cegla J (2010) Gut-brain cross-talk in appetite regulation. in Current opinion in clinical nutrition and metabolic care

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Choudhury SM (2016) Gastrointestinal hormones and their role in obesity. in Current opinion in endocrinology, diabetes, and obesity

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Curtis AE (2010) A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10. in American journal of physiology. Endocrinology and metabolism

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De Jonge C (2016) Impact of Duodenal-Jejunal Exclusion on Satiety Hormones. in Obesity surgery

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Falinska A (2014) Gut hormones and Type 2 diabetes mellitus in Diabetes Management

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Field BC (2010) Bowels control brain: gut hormones and obesity. in Nature reviews. Endocrinology

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Greenwood HC (2011) Peptides and their potential role in the treatment of diabetes and obesity. in The review of diabetic studies : RDS

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Hussain SS (2011) The pharmacological treatment and management of obesity. in Postgraduate medicine

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Jayasena CN (2009) Kisspeptin offers a novel therapeutic target in reproduction. in Current opinion in investigational drugs (London, England : 2000)

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Liu YL (2008) The effects of pancreatic polypeptide on locomotor activity and food intake in mice. in International journal of obesity (2005)

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McGowan BM (2008) Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis. in American journal of physiology. Endocrinology and metabolism

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McGowan BM (2009) Relaxin-3 and its role in neuroendocrine function. in Annals of the New York Academy of Sciences

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Papaioannou I (2011) Lack of association between impaired glucose tolerance and appetite regulating hormones in patients with obstructive sleep apnea. in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

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Parker JA (2012) Hypothalamic neuropeptides and the regulation of appetite. in Neuropharmacology

 
Company Name Thiakis 
Description Thiakis Ltd., an Imperial College spin out company was formed in 2004 to develop findings from Professor Bloom's laboratory into treatments for obesity and associated conditions. ; Acquired by Pfizer in 2008 
Year Established 2004 
Impact Thiakis raised £10 million funding in 2006, and was sold to Wyeth for £20 million followed by additional potential milestones payments totalling up to £80 million, in December 2008.
 
Description Knighthood honour for 'outstanding' obesity expert 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact http://www.bbc.co.uk/news/health-16363464

Publicity regarding laboratory's work.
Year(s) Of Engagement Activity 2012