Linking structure and function in the normal and in the disease human brain
Lead Research Organisation:
University of Oxford
Department Name: Medical Sciences Division
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Matthews PM
(2004)
Functional magnetic resonance imaging.
in Journal of neurology, neurosurgery, and psychiatry
Saini S
(2004)
Altered cerebellar functional connectivity mediates potential adaptive plasticity in patients with multiple sclerosis.
in Journal of neurology, neurosurgery, and psychiatry
Johansen-Berg H
(2004)
Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex.
in Proceedings of the National Academy of Sciences of the United States of America
Floyer-Lea A
(2004)
Changing brain networks for visuomotor control with increased movement automaticity.
in Journal of neurophysiology
Enzinger C
(2004)
Accelerated evolution of brain atrophy and "black holes" in MS patients with APOE-epsilon 4.
in Annals of neurology
Chen JT
(2004)
Relating neocortical pathology to disability progression in multiple sclerosis using MRI.
in NeuroImage
Arthurs OJ
(2004)
Attention differentially modulates the coupling of fMRI BOLD and evoked potential signal amplitudes in the human somatosensory cortex.
in Experimental brain research
Ciccarelli O
(2005)
Identifying brain regions for integrative sensorimotor processing with ankle movements
in Experimental Brain Research
Enzinger C
(2005)
Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects.
in Neurology
Schmidt R
(2005)
White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study.
in Annals of neurology
De Luca M
(2005)
Blood oxygenation level dependent contrast resting state networks are relevant to functional activity in the neocortical sensorimotor system.
in Experimental brain research
Pomeroy IM
(2005)
Demyelinated neocortical lesions in marmoset autoimmune encephalomyelitis mimic those in multiple sclerosis.
in Brain : a journal of neurology
Floyer-Lea A
(2005)
Distinguishable brain activation networks for short- and long-term motor skill learning.
in Journal of neurophysiology
Ciccarelli O
(2006)
Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis.
in Brain : a journal of neurology
Cader S
(2006)
Reduced brain functional reserve and altered functional connectivity in patients with multiple sclerosis.
in Brain : a journal of neurology
Floyer-Lea A
(2006)
Rapid modulation of GABA concentration in human sensorimotor cortex during motor learning.
in Journal of neurophysiology
De Luca M
(2006)
fMRI resting state networks define distinct modes of long-distance interactions in the human brain.
in NeuroImage
Devlin JT
(2006)
The role of the posterior fusiform gyrus in reading.
in Journal of cognitive neuroscience
Zarei M
(2006)
Functional anatomy of interhemispheric cortical connections in the human brain.
in Journal of anatomy
Ciccarelli O
(2006)
Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosis.
in Journal of neurology
Enzinger C
(2006)
Lesion probability maps of white matter hyperintensities in elderly individuals: results of the Austrian stroke prevention study.
in Journal of neurology
Tomassini V
(2007)
Diffusion-weighted imaging tractography-based parcellation of the human lateral premotor cortex identifies dorsal and ventral subregions with anatomical and functional specializations.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
David SP
(2007)
Effects of Acute Nicotine Abstinence on Cue-elicited Ventral Striatum/Nucleus Accumbens Activation in Female Cigarette Smokers: A Functional Magnetic Resonance Imaging Study.
in Brain imaging and behavior
Douaud G
(2007)
Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia.
in Brain : a journal of neurology
Blamire AM
(2007)
Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy.
in Magnetic resonance in medicine
Bhagwagar Z
(2007)
Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects.
in Biological psychiatry
Allen HA
(2008)
A neural marker of content-specific active ignoring.
in Journal of experimental psychology. Human perception and performance
Voets NL
(2008)
Evidence for abnormalities of cortical development in adolescent-onset schizophrenia.
in NeuroImage
Johansen-Berg H
(2008)
Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression.
in Cerebral cortex (New York, N.Y. : 1991)
Bosnell R
(2008)
Reproducibility of fMRI in the clinical setting: implications for trial designs.
in NeuroImage
Tamás Kincses Z
(2008)
Model-free characterization of brain functional networks for motor sequence learning using fMRI.
in NeuroImage
Giorgio A
(2008)
Changes in white matter microstructure during adolescence.
in NeuroImage
Stagg CJ
(2009)
Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Enzinger C
(2009)
Brain activity changes associated with treadmill training after stroke.
in Stroke
Stagg CJ
(2009)
Neurochemical effects of theta burst stimulation as assessed by magnetic resonance spectroscopy.
in Journal of neurophysiology
Zarei M
(2009)
Regional white matter integrity differentiates between vascular dementia and Alzheimer disease.
in Stroke
Stagg CJ
(2009)
Modulation of movement-associated cortical activation by transcranial direct current stimulation.
in The European journal of neuroscience
Menke RA
(2010)
Connectivity-based segmentation of the substantia nigra in human and its implications in Parkinson's disease.
in NeuroImage
Sloan HL
(2010)
Regional differences in neurovascular coupling in rat brain as determined by fMRI and electrophysiology.
in NeuroImage
Menke R
(2010)
Connectivity-based segmentation of the substantia nigra in human and its implications in Parkinson's disease
in NeuroImage
Zarei M
(2010)
Combining shape and connectivity analysis: an MRI study of thalamic degeneration in Alzheimer's disease.
in NeuroImage
Wise RG
(2010)
Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxia.
in Magnetic resonance imaging
Giorgio A
(2010)
Longitudinal changes in grey and white matter during adolescence
in NeuroImage
Tomassini V
(2011)
Structural and functional bases for individual differences in motor learning.
in Human brain mapping
Crofts JJ
(2011)
Network analysis detects changes in the contralesional hemisphere following stroke.
in NeuroImage
Bosnell RA
(2011)
Motor practice promotes increased activity in brain regions structurally disconnected after subcortical stroke.
in Neurorehabilitation and neural repair
| Description | Public consultation roll out of participant involvement in research- MRC/WT sponsorted |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Impact | Changes in perception of clinical trials |
| Description | Centre for Mathematics of Precision Healthcare |
| Amount | £1,899,999 (GBP) |
| Funding ID | EP/N014529/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 09/2019 |
| Description | Dementias Platform |
| Amount | £4,500,000 (GBP) |
| Funding ID | MR/L023784/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 03/2019 |
| Description | MRC Experimental Medicine |
| Amount | £897,903 (GBP) |
| Funding ID | MR/N026934/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2019 |
| Description | MS Society Project grant |
| Amount | £175,000 (GBP) |
| Organisation | Multiple Sclerosis Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2003 |
| End | 03/2006 |
| Description | OPTIMISE |
| Amount | € 725,000 (EUR) |
| Organisation | Biogen |
| Sector | Private |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 08/2017 |
| Description | Pilot Grant |
| Amount | € 74,995 (EUR) |
| Organisation | International Progressive MS Alliance |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2014 |
| End | 07/2015 |
| Description | Pilot Grant |
| Amount | £75,000 (GBP) |
| Organisation | Multiple Sclerosis Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2015 |
| End | 06/2016 |
| Description | Senior Investigator Award |
| Amount | £450,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2015 |
| End | 02/2020 |
| Description | WT-GSK Clinical Training Fellowships |
| Amount | £2,750,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2008 |
| End | 08/2017 |
| Title | FSL |
| Description | On line software analysis |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Widespread academic and pharmaceutical use |
| Description | Austrian Stroke Study |
| Organisation | Medical University of Graz |
| Department | Department of Neurology |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | Advanced analysis support; mentorship for trainees; interpretative framework |
| Collaborator Contribution | Data. fellow for analysis |
| Impact | Publications |
| Description | FMRIB Centre Oxford |
| Organisation | John Radcliffe Hospital |
| Department | Centre for Functional MRI of the Brain (fMRI) |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Collaborative supervision of fellows and research |
| Collaborator Contribution | Collaborative research, support for fellows and students, research environment |
| Impact | Papers since 2006 with FMRIB coauthors |
| Description | Stroke adaptive plasticity |
| Organisation | GlaxoSmithKline (GSK) |
| Department | Neurology and GI Centre of Excellence for Drug Discovery (CEDD) GSK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Proposed extenstion of current work as paradigm for evaluation of new drug targeting plasticity |
| Collaborator Contribution | Provision of leadership, target objectives |
| Impact | Publications |
| Start Year | 2006 |
| Description | UK Biobank |
| Organisation | UK Biobank |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Expert input as member of steering committee and chair of working group |
| Collaborator Contribution | Organisational structure and expertise |
| Impact | Open access to database 2013 Publications describing Imaging Enhancment Successful funding for imaging enhancement and set up of new centre |
| Start Year | 2008 |
| Description | Univ of Siena |
| Organisation | University of Siena |
| Department | Clinical Neurosciences |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Research training, software, guidance for new problems |
| Collaborator Contribution | Data, research support |
| Impact | Publications, support for R and D in GlaxoSmith Kline |
| Start Year | 2006 |
| Title | GlaxoSmithKline Early Development |
| Description | Over last 5 years, research and group have contributed to development of more than 18 different molecules in early development (see letter from Dr. Phil Murphy in 2013 REF submission). Here these contributions all have been "lumped" into a single entry |
| Type | Therapeutic Intervention - Drug |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2013 |
| Development Status | Actively seeking support |
| Impact | reducing costs for commercial development, increased competitiveness of UK environment |
| Description | Bard |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Wrote popular book to highlight brain research- "Bard on the Brain". Follow up lectures. Led to creation of Oxford Centre for the Creative Brain Multiple public presentation requests inUK, Europe and US |
| Year(s) Of Engagement Activity | 2006,2009,2015 |
| Description | Consortium of MS Centers Annual Meeting, Montreal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Consortium of MS Centers Annual Meeting, Montreal, Canada 1 June 2011 - Lessons from brain plasticity in multiple sclerosis Improved understanding for better care management especially by nurses |
| Year(s) Of Engagement Activity | 2011 |
| Description | European Dana Alliance |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Public lectures Contact for followup book |
| Year(s) Of Engagement Activity | 2006,2007,2008 |
| Description | London Health Forum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | 2013 London Health Forum, Korean Healthcare IDI, London, May 2013 - Opportunities for International Collaborative Healthcare Science Commercial engagement with UK academic base |
| Year(s) Of Engagement Activity | 2013 |
| Description | U3A Annual Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | U3A Annual Conference, East Grinstead, UK - Healthy brain aging Better informed lay audience |
| Year(s) Of Engagement Activity | 2013 |