Acute Brain Injury: herterogeneity of Mechanisms, Therapeutic Targets and Outcome Effects
Lead Research Organisation:
University of Cambridge
Department Name: Wolfson Brain Imaging Centre
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- University of Cambridge, United Kingdom (Collaboration, Lead Research Organisation)
- Antwerp University Hospital (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- Chemnitz Academic Teaching Hospital (Collaboration)
- International Neurotrauma Society (INTS) (Collaboration)
- University of Bath, Bath (Collaboration)
- Kiel University, Germany (Collaboration)
- Newcastle University, United Kingdom (Collaboration)
- Intensive Care Society (Collaboration)
- University of Groningen (Collaboration)
- Royal College of Physicians of London (Collaboration)
- Advion Biosciences, United Kingdom (Collaboration)
- Society of British Neurological Surgeons (Collaboration)
- University of Lisbon (Collaboration)
- Albert Ludwigs University of Freiburg (Collaboration)
- University of Calgary, Canada (Collaboration)
- Siemens Healthcare (Collaboration)
- University of Melbourne, Australia (Collaboration)
- University of Otago, New Zealand (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Cornell University (Collaboration)
- Medical Research Council (Collaboration)
- Memphis University (Collaboration)
- National Institutes of Health, United States (Collaboration)
- The Royal College of Anaesthetists (Collaboration)
- Queen's Medical Centre (Collaboration)
- European Brain Injury Consortium (EBIC) (Collaboration)
- University of Liege, Belgium (Collaboration)
- Charité - University of Medicine Berlin (Collaboration)
Publications
Abate MG
(2008)
Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity.
in Neurocritical care
Absalom AR
(2009)
BIS and spectral entropy monitoring during sedation with midazolam/remifentanil and dexmedetomidine/remifentanil.
in Critical care (London, England)
Achard S
(2006)
A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Achard S
(2007)
Efficiency and cost of economical brain functional networks.
in PLoS computational biology
Acosta-Cabronero J
(2010)
Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease.
in Brain : a journal of neurology
Acosta-Cabronero J
(2008)
The impact of skull-stripping and radio-frequency bias correction on grey-matter segmentation for voxel-based morphometry.
in NeuroImage
Al-Rawi PG
(2000)
Multiparameter brain tissue monitoring--correlation between parameters and identification of CPP thresholds.
in Zentralblatt fur Neurochirurgie
Allin D
(2008)
Laboratory testing of the Pressio intracranial pressure monitor.
in Neurosurgery
Allin DM
(2008)
Investigation of the hydrodynamic properties of a new MRI-resistant programmable hydrocephalus shunt.
in Cerebrospinal fluid research
| Description | Brain Death Guidelines |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | JDP - Brain Death Guidelines Working Party (Royal College of Anaesthetists); liason with Official Solicitor over implications of advances in functional brain imaging for the management of patients in the vegetative state. |
| Description | Chairman of Review of the assessment of cumulative severity and lifetime experience in non-human primates used in neuroscience research. Novemebr 2013. Report on behalf of the Animal Procedures Committee. |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Description | Clinical Leads |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | JPC is clinical lead for Critical Care & DKM is clinical lead for Anaesthesia within the West Anglian Comprehensive Local Research Network. Both are representatives on the National Speciality Groups. |
| Description | Demographics and Clinical Assessment Working Group |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Professor of Anaesthesia is member of Demographics and Clinical Assessment Working Group which participated in the NIH/NINDS initiative developing develop common data elements for TBI. The overall process leading to the workshop and the subsequent recommendations by the working groups are published in the Archives of Physical Medicine and Rehabilitation. (http://www.commondataelements.ninds.nih.gov/TBI.aspx |
| URL | http://www.springerlink.com/content/u028t28013214524/ |
| Description | Faculty of Intensive Care Medicine, and academic training |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | In June 2010, the creation of the Faculty of ICM which will henceforth represent the device for setting standards through education and training. |
| Description | Guidelines for clinical trials in TBI |
| Geographic Reach | National |
| Policy Influence Type | Participation in a national consultation |
| Description | Guidelines on application of Mental Health Capacity Act in critical care contexts. |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | This document has completed a period of consultation and is being finalised as Guidance for UK ICUs by the Intensive Care Society (UK) |
| Description | Home Office Animal Procedures Commitee and Primate Subcommittee |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | JDP - Home Office Animal Procedures Committee and Primate Subcommittee [Chairman]. Chairman of 'Pickard Report on Cumulative Severity and lifetime experience in non-human primates used in neuroscience research' published November 2013. |
| Description | Home Office Animal Procedures Committee and Primate Subcommittee |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guidance committee |
| Impact | JDP - Home Office Animal Procedures Committee and Primate Subcommittee [Chairman]. JDP chaired the 'Pickard' Report: Review of the assessment of cumulative severity and lifetime experience in non-human primates used in neuroscience research. |
| Description | House of Lords Pandemic influenza enquiry |
| Geographic Reach | National |
| Policy Influence Type | Gave evidence to a government review |
| URL | http://books.google.co.uk/books?id=gttFlHWv4FgC&pg=PA61&lpg=PA61&dq=Menon+pandemic+flu&source=bl&ots... |
| Description | London/GMEC PET Centre Feasibilty Working Group |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Membership of a guideline committee |
| Description | MHRA MRC NCRI Group on Regulatory Issues in PET Research |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | MRC MHRA PET Expert Panel |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Description | MRC PET Neuroscience postdoctoral tarining award: August 2009 |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Management of incidentalomas identified in research brain scans of volunteers. |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| Impact | This ethical problem has now become a major issue - see recent Wellcome/SINAPSE ,meeting 2010 and Wardlaw report in BMJ 2015 referenced above |
| Description | Membership of NIHR Integrated Academic Training review panel |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | The scheme is intended to provede research exposure and experience for academically gifted medical and dental trainees with potential to be independant researchers of the future. |
| Description | Mental Health Capacity |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Impact | • DKM - Intensive care society: development of new legislation and regulations concerning Mental Capacity, Human Tissue Act, Clinical Trials Directive, data Protection Act. |
| Description | Mental Health Capacity, Human Tissue Act, Clinical Trials Directive, Data Protection Act |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Impact | DKM - Intensive care society: development of new legislation and regulations concerning Mental Capacity, Human Tissue Act, Clinical Trials Directive, data Protection Act. |
| Description | Microdialysis |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a advisory committee |
| URL | http://europepmc.org/abstract/MED/15549254 |
| Description | NCRI PET Steering Committee |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Guideline Title | Head injury: assessment and early management |
| Description | NICE Guidelines for the management of TBI |
| Geographic Reach | National |
| Policy Influence Type | Citation in clinical guidelines |
| Impact | DKM was a member on the group revising NICE Guidelines for the management of TBI (Triage, assessment, investigation and early management of head injury in infants, children and adults. http://www.nice.org.uk/CG056; 2007). PJAH was a member of the updating committee 2014 |
| URL | http://www.nice.org.uk/CG176 |
| Description | National guidelines for the implementation of the Mental Capacity Act in Intensive Care Units |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | National guidelines for the implementation of the Mental Capacity Act in Intensive Care Units (see: http://www.ics.ac.uk/intensive_care_professional/standards_and_guidelines/mental_capacity_act) |
| URL | http://www.ics.ac.uk/intensive_care_professional/standards_and_guidelines/mental_capacity_act |
| Description | Neurosurgical Representative on the current NICE Committee revising the NICE guidelines for the early management of head injury in adults and children (due to be published published in 2013/4) |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Head injury guidelines |
| Description | SMART |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | The Division of Anaesthesia, University of Cambridge organises the SMART (Scientific Methods and Research Training) course for clinical trainees. This course is open to all trainees in Anaesthesia in the UK |
| Guideline Title | PROLONGED DISORDERS OF CONSCIOUSNESS - NATIONAL CLINICAL GUIDELINES (ROYAL COLLEGE OF PHYSICIANS OF LONDON) |
| Description | Using functional imaging to detect covert cognition in the vegetative state - mapping the translation from research finding to patient management framework |
| Geographic Reach | National |
| Policy Influence Type | Citation in clinical guidelines |
| Impact | There is a misdiagnosis rate of 40% in cases of vegetative state and other prolonged disorders of consciousness. Some of the key publications arising from our research are listed below, and are underpinned by research grants from the National Institute for Health Research (through the Neuroscience theme of the Cambridge Biomedical Research Centre), the Medical Research Council, the Royal College of Anaesthetists, the McDonnell Foundation, and the Henry Smith Charity. Perhaps even more relevant than individual publications or grant income is the establishment of strong and productive national and international networks that now address the scientific and clinical issues in this area through a common, integrated research program. These studies were conducted as part of a close collaboration with the MRC Cognition and Brain Sciences Unit, Cambridge, Our international collaborators include Liege University, Cornell University, and University of Western Ontario. Our national collaborators include the Royal National Hospital for Neurodisability, Putney; The Royal Leamington Spa Rehabilitation Hospital; The Coleman Centre, Norwich; The Jacob Centre, Sawbridgeworth; and Leicester Royal Infirmary. While this latter network may not have the scientific track record of our international partners, it has represented a key resource for research recruitment in the past, and will be an essential framework for disseminating best practice and new paradigms of patient management. There are likely to be less than 500 patients with VS in England and Wales at any time, and, if research is to progress, a close collaborative relationship is essential between academic centres and clinical units that care for these patients. These clinical networks will be widened to disseminate the clinical assessment and imaging paradigms that we have developed for adoption into regional and national protocols. These protocols, which have been trialled and refined within our research program, are already providing data that inform the management of patients who are referred to us. Over time, this will be disseminated to other centres to characterise such patients, and eventually select patients for clinical trials of novel therapies. Our research has also informed the debate on national legislation. Kate Bainbridge, who was the subject of our original Lancet paper on residual cognition in the vegetative state, has made a substantial cognitive recovery.a Kate has since published a book and two papersb,c describing her recovery, and is someone we turn to when considering difficult ethical issues. Her input during the Mental Capacity Act debate helped convince the Government that research in incapacitated individuals was clearly ethical. These contributions at parliamentary committee stages of the Mental Capacity Act and during the implementation of the Clinical Trials Regulations resulted in important modifications that ensured that research in critical care and emergency medicine could continue. Finally, our research has had substantial (and far broader) societal impact on perceptions of neurological recovery. Our contributions to national broadcast media have informed public knowledge and professional debate in this area. In 2010, we hosted a BBC team, who produced a program addressing the difficult area of poor quality survival from brain injury. The resulting program, "Between Life and Death",d,e,f was broadcast on BBC 1 on the 14th of July 2010, and won the Royal Television Society Awardg and the British Academy of Film and Television Arts (BAFTA) Awardh for best single documentary. More recently, our input has contributed to the public debate on management of patients with disorders of consciousness as part of the BMA Morals and Medicine series,i and our research has recently featured on BBC 1's Panorama program.j Sources to corroborate the impact (indicative maximum of 10 references) a. http://www.youtube.com/watch?v=A04AvsGH0FU b. Macniven JA, Poz R, Bainbridge K, Gracey F, Wilson BA. Emotional adjustment following cognitive recovery from 'persistent vegetative state': psychological and personal perspectives. Brain Inj 2003;17(6):525-33. PMID: 12745707. c. Wilson BA, Gracey F, Bainbridge K. Cognitive recovery from "persistent vegetative state": psychological and personal perspectives. Brain Inj 2001;15(12):1083-92. PMID: 11712954. d. http://www.bbc.co.uk/programmes/b00t3szs e. http://www.bbc.co.uk/blogs/tv/2010/07/between-life-and-death-why-med.shtml f. http://www.telegraph.co.uk/health/7868034/Unlocking-lives-trapped-in-limbo.html g. http://www.rts.org.uk/winners-rpa h. http://www.bafta.org/awards-database.html?year=2010&category=Television&award=Single+Documentary i. http://www.bbc.co.uk/programmes/b01ny377 j. http://bma.org.uk/practical-support-at-work/ethics/withdraw-withhold-artificial-nutrition-and-hydration Some key references from the Cambridge Research in to Impaired Consciousness Group that I have chaired for the past 20 years: 1. Menon DK, Owen AM, Williams EJ, Minhas PS, Allen CM, Boniface SJ, Pickard JD. Cortical processing in persistent vegetative state. Wolfson Brain Imaging Centre Team. Lancet. 1998;352: 200. PMID: 9683212. 2. Davis MH, Coleman MR, Absalom AR, Rodd JM, Johnsrude IS, Matta BF, Owen AM, Menon DK. Dissociating speech perception and comprehension at reduced levels of awareness. Proc Natl Acad Sci U S A 2007; 104: 16032-7. PMID:17938125. 3. Coleman MR, Davis MH, Rodd JM, Robson T, Ali A, Owen AM, Pickard JD. Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousness. Brain 2009;132: 2541-52. PMID: 19710182. 4. Owen AM, Coleman MR, Boly M, Davis MH, Laureys S, Pickard JD. Detecting awareness in the vegetative state. Science 2006; 313: 1402. PMID: 16959998. 5. Monti MM, Vanhaudenhuyse A, Coleman MR, Boly M, Pickard JD, Tshibanda L, Owen AM, Laureys S. Willful modulation of brain activity in disorders of consciousness. N Engl J Med 2010; 362: 579-89. PMID: 20130250. 6. Newcombe VF, Williams GB, Scoffings D, Cross J, Carpenter TA, Pickard JD, Menon DK. Aetiological differences in neuroanatomy of the vegetative state: insights from diffusion tensor imaging and functional implications. J Neurol Neurosurg Psychiatry 2010; 81:552-61. PMID: 20460593. 7. Cruse D, Chennu S, Chatelle C, Fernández-Espejo D, Bekinschtein TA, Pickard JD, Laureys S, Owen AM. Relationship between etiology and covert cognition in the minimally conscious state. Neurology 2012; 78:816-22. PMID: 22377810. 8. Cruse D, Chennu S, Chatelle C, Bekinschtein TA, Fernández-Espejo D, Pickard JD, Laureys S, Owen AM. Bedside detection of awareness in the vegetative state: a cohort study. Lancet 2011; 378: 2088-94.PMID: 22078855. |
| Description | international panel on guidelines for the intensive care management of subarachnoid haemorrhage |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Professor of Anaesthesia is a member of international panel on guidelines for the intensive care management of subarachnoid haemorrhage (http://www.springerlink.com/content/u028t28013214524/) |
| URL | http://www.springerlink.com/content/u028t28013214524/ |
| Description | Academy of Medical Sciences/PPP - Senior Surgical Scientist Scheme Fellowship |
| Amount | £426,210 (GBP) |
| Organisation | Academy of Medical Sciences (AMS) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Brain Injury and Repair Theme |
| Amount | £541,696 (GBP) |
| Funding ID | RG64341 |
| Organisation | National Institute for Health Research |
| Department | NIHR Cambridge Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2012 |
| End | 03/2017 |
| Description | British Journal of Anaesthesia/Royal College of Anaesthetists project grant: Imaging |
| Amount | £52,856 (GBP) |
| Organisation | The Royal College of Anaesthetists |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Cambridge PET Neurochemist Programme |
| Amount | £745,000 (GBP) |
| Funding ID | G0900903 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Cerebral Energy Metabolism in Injured and Uninjured Brain |
| Amount | £504,688 (GBP) |
| Funding ID | G1002277 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Cerebral Energy Metabolism in Injured and Uninjured Brain. |
| Amount | £504,688 (GBP) |
| Funding ID | G1002277 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Department of Health Technology Platform |
| Amount | £1,896,880 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Developing the WTCRF in Cambridge: Magnetic Resonance Spectroscopy an da Nutrition Resource & Appetite Laboratory. |
| Amount | £2,782,604 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | EU FP7 Program: Collaborative European NeuroTrauma Effectiveness REsearch in TBI: CENTER-TBI |
| Amount | € 30,000,000 (EUR) |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | EU Fellowship for Dr Jeroen Hermanides € |
| Amount | € 97,727 (EUR) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | EU Framework 7 |
| Amount | £422,817 (GBP) |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 02/2011 |
| End | 01/2014 |
| Description | EU Framework Program 7 |
| Amount | € 4,245,377 (EUR) |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | EU Multicentre Project grant |
| Amount | £300,000 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Engineering and Physical Science High Resolution Simultaneous PET-MR Scanner. Awarded |
| Amount | £1,082,585 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Evelyn Trust - Cognitive dysfunction after head injury: neuroanatomical correlates |
| Amount | £120,400 (GBP) |
| Organisation | The Evelyn Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Evelyn Trust - Role of inflammation and neovasculatirsation in expansion of small AAA. |
| Amount | £72,000 (GBP) |
| Organisation | The Evelyn Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Fellowship |
| Amount | £143,419 (GBP) |
| Organisation | National Institute of Academic Anaesthesia |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | |
| Description | Hyperoxic modulation of tissue lactate in head injury |
| Amount | £100,000 (GBP) |
| Organisation | The Royal College of Anaesthetists |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | IMAGEN Reinforcement-related behaviour in normal brain function and psychopathology |
| Amount | £600,000 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Imaging Theme co-applicant |
| Amount | £6,700,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Cambridge Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Imaging inflammation in atherosclerosis: An integrated multimodality approach |
| Amount | £1,139,380 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Imaging inflammation in atherosclerosis: an integrated multimodality approach |
| Amount | £591,252 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Imaging mechanisms of energy failure following head injury. |
| Amount | £220,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Imaging the surviving penumbra and recovery after stroke |
| Amount | £843,000 (GBP) |
| Funding ID | G0500874 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Impulsivity and compulsion in humans and other animals: neural and neurochemical substrates |
| Amount | £1,550,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Interrogating energy metabolism in human brain using 13C microdialysis and magnetic resonance spectroscopy |
| Amount | £475,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Lang Fellowship, Research Fellowship |
| Amount | £40,000 (GBP) |
| Organisation | Royal College of Surgeons of England |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | |
| Description | MICA: Detecting ictogenicity and epileptogenesis |
| Amount | £1,635,366 (GBP) |
| Funding ID | MR/L013215/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 03/2019 |
| Description | MICA: Training and Novel Probes Programme in PET Neurochemistry - PET Call |
| Amount | £1,016,892 (GBP) |
| Funding ID | MR/K02308X/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 12/2013 |
| End | 11/2017 |
| Description | MRC - Decompressive Craniectomy Study |
| Amount | £1,006,309 (GBP) |
| Funding ID | G0601025 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | MRC Acute Brain Imaging Collaborative Grant |
| Amount | £1,357,662 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | MRC Cambridge Centre for Behavioural and Clinical Neuroscience |
| Amount | £1,815,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | MRC programme Grant |
| Amount | £775,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | MRC/RCS Clinical Research Training Fellowship |
| Amount | £100,000 (GBP) |
| Organisation | Royal College of Surgeons of England |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | |
| Description | MRC/RCS Clinical Research Training Fellowship |
| Amount | £105,224 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Multi-level patient-specific artery and athero-genesis model for outcome prediction, decision support treatment, and virtual hands-on training. |
| Amount | £425,753 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | NIHR BRC |
| Amount | £1,892,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2017 |
| Description | NIHR Biomedical research Centre |
| Amount | £1,600,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Cambridge Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | NIHR Brain Injury MedTech Co-operative |
| Amount | £1,250,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2022 |
| Description | NIHR Clinician Scientist Award |
| Amount | £940,146 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | NIHR Global Health |
| Amount | £1,800,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 07/2020 |
| Description | NIHR HTC |
| Amount | £5,200 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2017 |
| Description | NIHR HTC for Brain Injury |
| Amount | £800,000 (GBP) |
| Organisation | Barts Health NHS Trust |
| Department | NIHR Biomedical Research Unit |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 12/2017 |
| Description | NIHR, Biomedical Research Unit in Dementia Capital Funding |
| Amount | £1,537,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | National Institute for Health Research Biomedical Research Centre |
| Amount | £720,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Cambridge Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Neurobiological correlates of trait impulsifvity an ddrug abuse vulnerability |
| Amount | £1,134,962 (GBP) |
| Funding ID | G0701500 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | New drugs for addiction: focus on attenuating core behavioural component of heroin, cocaine and alcohol addiction and relapse prevention. |
| Amount | £1,774,000 (GBP) |
| Funding ID | G1000018 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Novel Mitochondria-targeted PET probe |
| Amount | £82,500 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | RESCUEicp |
| Amount | £1,116,980 (GBP) |
| Funding ID | G0601025 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Research Fellowship |
| Amount | £46,014 (GBP) |
| Organisation | Royal College of Surgeons of England |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | |
| Description | Risk Adjustment in Neurocritical Care (RAIN)/Health Technology Agency |
| Amount | £617,028 (GBP) |
| Organisation | National Institute for Health Research |
| Department | Health Technology Assessment Programme (HTA) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | SPARCS - The Children Medical Research Charity |
| Amount | £117,124 (GBP) |
| Organisation | Sparks |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2013 |
| End | 09/2015 |
| Description | Sleep and circadian rhythms in moderate and severe traumatic brain injury |
| Amount | £420,000 (GBP) |
| Organisation | Canadian Institutes of Health Research |
| Sector | Public |
| Country | Canada |
| Start | |
| Description | Stroke Association |
| Amount | £139,500 (GBP) |
| Funding ID | TSA2011/08 |
| Organisation | Stroke Association |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Surgical Research Fellowship |
| Amount | £50,000 (GBP) |
| Organisation | Royal College of Surgeons of England |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | |
| Description | Temporal Pattern and Metabolic Correlates of Neuronal Loss After Head Injury (British Oxygen Professorship) |
| Amount | £351,074 (GBP) |
| Organisation | Academy of Medical Sciences (AMS) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | The British Oxygen Professorship: Imaging anaesthetic action in the brain. |
| Amount | £320,943 (GBP) |
| Organisation | The Royal College of Anaesthetists |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | The Evelyn Trust. Cognitive disfunction after head injury:Neuroanatomical correlates and drug therapy/Evelyn Trust |
| Amount | £120,400 (GBP) |
| Organisation | The Evelyn Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | The HIF system in traumatic brain injury. |
| Amount | £188,599 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Towards a biomechanics-based vulnerability assessment tool for carotid atherosclerotic plaque: mechanical property testing and MRI-based computaional modelling |
| Amount | £193,818 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Vegetative State |
| Amount | $500,000 (USD) |
| Organisation | James S. McDonnell Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 08/2013 |
| End | 07/2017 |
| Title | CAD&CAM for MRE |
| Description | In the process of developing the MRE method we have introduced computer added design software (SpaceClaim) combined with manufacturing on a 3D printer (HP Designjet 3D). This allows for assessment of structure strength and design flaws before manufacturing, considerably reducing the costs of manufacturing |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | We managed to design and manufacture actuation devices used for MRE and disseminate them across our partners |
| Title | ICM+ Sofware licensed |
| Description | Optimisation of real time analysis of multimodal monitoring data and its application to computer guided management of head injury patients In an established environment of neuro-intensive care large quantities of data can be captured from bed-side monitors. This data contains a wealth of information about the pathophysiology of the critically ill patient however the extraction of this information often requires sophisticated signal analysis. Such analysis is usually performed using universal data analysis packages like Matlab but requires engineering/mathematics expertise and is only available in off-line mode and as such in not applicable in a clinical setting. Our own software ICM+ (http://www.neurosurg.cam.ac.uk/icmplus), which is by now used in many clinical centres worldwide, attempts to bridge the gap between laboratory and clinical application. It collects data from bedside monitors, calculates in real time 'secondary' parameters defined using highly configurable signal processing formulae and produces continuously updated charts. This way complex information coming off the bedside monitors can be summarized in a concise fashion and presented to medical staff in a simple way that alerts them to the development of various pathological processes. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | The projects offered will include the following stages: 1. Development of new methodologies of analysis of physiological signals acquired in the Neuro Intensive Care, including time and frequency domain, stationary and non-stationary methods, linear and non-linear approaches. 2. Validation of the new methodologies against retrospective and prospective data from the Neuro Intensive Care unit 3. Implementation of the novel algorithms into ICM+ plugins, packaged as Windows dll libraries, so that they can be used in real time by the bed side |
| URL | http://www.neurosurg.cam.ac.uk/icmplus |
| Title | In-line MRE analysis |
| Description | This is an add-on to the image acquisition sequence that allows the calculation of elastograms at the point of acquisition without the need of additional materials of knowledge. |
| Type Of Material | Data analysis technique |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | The tool allows non-expert operators to acquire MRE data and assess data quality. This makes this a valuable clinical tool |
| Title | MICL |
| Description | Establishment of the Molecular Imaging Chemistry Laboratory at Forvie Site, Cambridge Biomedical Campus, Cambridge (2008): a dedicated facility for the development, synthesis and evaluation of novel imaging probes. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | Major new grants to support dementia initiative |
| Title | Microfluidic methods for PET radiopharmaceuticals |
| Description | Development of microfluidic methods for the preparation of PET radiopharmaceuticals |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | TBD |
| Title | Novel 11C-METHIONINE PET for pituitary micro adenomas |
| Description | Functioning pituitary micro adenomas can be very difficult to identify on conventional MR scanning. Dr Mark Gurnell, Dr Franklin AIgbirhio and Professor Pickard in collaboration with colleagues have developed a PET imaging technique based on 11C-Methionine based on an initial contribution of £10000 from JDP's Senior Investigator Award.The Cambridge Pituitary MDT Clinic now attracts tertiary referrals from throughout the UK and abroad for this technique. Oral/pleanry presentations have been given in San Francisco, Sydney and Munich. 3 major papers are in preparation. |
| Type Of Material | Model of mechanisms or symptoms - human |
| Provided To Others? | No |
| Impact | A very difficult group of patients with refractory functioning pituitary micoadenomas are now being offered highly selective endoscopic re-do pituitary operations thereby improving outcomes and reducing the need for expensive and ineffective drug therapies. |
| Title | Pneumatic Actuator for MRE |
| Description | This actuator consists of an loudspeaker connected to a drum-like element via a plastic tube. This is used for mechanical excitation of tissue. The device does not require additional filtering in the MR environment, is portable and versatile. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | The device is a complement to the existing equipment and has the advantage of being portable. This opens the opportunity to easily disseminate the method to other research partners worldwide. |
| Title | UK Neurocritical Care Network (NCCNet) |
| Description | DKM is the Research and Project Lead for the UK Neurocritical Care Network (NCCNet), a collaborative of 20 plus critical care units involved in the care of neurological patients. This provides the infrastructure for clinical research and trials |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2007 |
| Provided To Others? | Yes |
| Impact | as per above |
| Title | functional MR and EEG paradigms for assessment of covert awareness |
| Description | Study of patients in low awareness states requires the development of psychological paradigms that can be applied in brain scanners including PET and MR. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Major papers in Science, NEJM and worldwide publicity |
| Title | Outcome Registry, Intervention and Operation Network (ORION) |
| Description | ORION is a generic, cloud-based and temporally-specific application developed by Dr Alexis Joannides (Clinical Lecturer in Neurosurgery) as part of the NIHR Brain Injury HTC that allows secure and controlled access to structured healthcare information across multiple sites. It forms the basis for the NIHR Brain Injury HTC information hub and includes: National Prospective Databases - UK CSF Shunt Registry, Vestibular SChwannoma Registry and the DH-funded Children's Epilepsy Surgery Service Service tools - Major Trauma Rehabilitation Prescription, Neuroscience Emergency Referrrals, Ward tai list, NF-2 quality of life collection Studies and audits - Melatools-Q, EPIPEG, Neurooncology Quality of life (recent Innovate UK DAMSEL award), Chronic subdural hamatoma audit, Impaired consciousness Research database. |
| Type Of Material | Data handling & control |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | The UK shunt Registry was established some 20 years ago and now includes over 70,000 operations and 35,000 patients. It has been an invaluable authoritative and independent source of data for the MDA (now MHRA), neurosurgery units and for research (e.g. case control study of antibiotic impregnated shunt catheters). |
| Title | UK shunt registry |
| Description | The UK shunt registry was establish some 20 years ago and now includes data on over 70,000 hydrocephalus shunt operations in over 35,000 patients. |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Annual reports have confirmed that there are no neurosurgery units where the cumulative failure rate for shunts nor infection rates are persistent outliers. Case control studies have demonstrated the efficacy of antibiotic shunt catheters. The registry has been able to provide the data on which to power hydrocephalus shunt RCTs/ |
| Description | 13C-labelled microdialysis |
| Organisation | University of Calgary |
| Department | Section of Neurosurgery |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | 13C labelling studies of brain metabolism using microdialysis in traumatic brain injury patients. |
| Collaborator Contribution | Our collaborator has visited us in Cambridge on a Visiting Fellowship (awarded by the Canadian Institute of Health Research). The collaboration is ongoing and our collaborator is a Co-investigator on a current MRC Research Grant (PI: Peter Hutchinson, G1002277 ID 98489). |
| Impact | Publication: Gallagher CN, Carpenter KL, Grice P, Howe DJ, Mason A, Timofeev I, Menon DK, Kirkpatrick PJ, Pickard JD, Sutherland GR, Hutchinson PJ. The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study. Brain. 2009 Oct;132(Pt 10):2839-2849. PubMed PMID: 19700417. |
| Start Year | 2006 |
| Description | 13C-labelled microdialysis |
| Organisation | University of Calgary |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Division of nNeurosurgery (University of Cambridge) hosted Dr Clare Gallagher for a visitnig fellowship, funded by the Canadian Institure of Health Research. |
| Collaborator Contribution | Our collaborator has visited us in Cambridge on a Visting Fellowship (awarded by the CAnadian Institute of Health Research). The collaboration is ongoing and our collaborator is a Co-investigator on a current MRC Research Grant (PI: Peter Hutchinson, G1002277 ID 98489). |
| Impact | PMID: 19700417 |
| Start Year | 2006 |
| Description | Altered States of Consciousness - International Collaborations |
| Organisation | Cornell University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Pickard JD: Collaobrations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor. |
| Impact | See publications lists and new grants. |
| Description | Altered States of Consciousness - International Collaborations |
| Organisation | Royal College of Physicians of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Pickard JD: Collaobrations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor. |
| Impact | See publications lists and new grants. |
| Description | Altered States of Consciousness - International Collaborations |
| Organisation | The Royal College of Anaesthetists |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Pickard JD: Collaobrations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor. |
| Impact | See publications lists and new grants. |
| Description | Altered States of Consciousness - International Collaborations |
| Organisation | University of Liege |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | Pickard JD: Collaobrations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor. |
| Impact | See publications lists and new grants. |
| Description | Altered States of Consciousness - International Collaborations |
| Organisation | University of Melbourne |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Pickard JD: Collaborations with S Laureys (Liege Belgium) and N Schiff (Cornell, New York); national working parties on Vegetative State (Royal College of Physcicians) and Brain Death (Royal College of anaesthetists); liason with the Official Solicitor |
| Impact | See publications lists and new grants. |
| Description | Application of PET in addiction research |
| Organisation | University of Cambridge |
| Department | Department of Psychology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Application of PET in addiction research. |
| Impact | n/a |
| Start Year | 2010 |
| Description | British Neurosurgical Trainee Research Collaborative |
| Organisation | Society of British Neurological Surgeons |
| Country | United Kingdom |
| Sector | Learned Society |
| PI Contribution | AK and PH led the efforts to establish the British Neurosurgical Trainee Research Collaborative. The BNTRC is a research network for trainees which will aim to develop, run and support neurosurgical trials. |
| Collaborator Contribution | The SBNS has very generously supported this initiative since its inception. |
| Impact | PMID: 22583319 |
| Start Year | 2012 |
| Description | British Neurotrauma Group |
| Organisation | Society of British Neurological Surgeons |
| Country | United Kingdom |
| Sector | Learned Society |
| PI Contribution | Initiative to set up a special-interest group within the Society of British Neurological Surgeons |
| Collaborator Contribution | Increasing understanding of the issues surrounding decompressive craniectomy in head injury |
| Impact | The first academic meeting of the group took place in 2010 (October). The meeting was attended by neurosurgeons, neurorehabilitation consultants, endocrinologists, neurologists and specialist nurses. |
| Start Year | 2008 |
| Description | Council of Intensive Care Society |
| Organisation | Intensive Care Society |
| Country | United Kingdom |
| Sector | Learned Society |
| PI Contribution | D.K Menon: Council of the Intensive Care Society - special respnsibility for the development of new legislation and regulations concerning Menal Capacity, Human Tissue Act, Clinical trials Directive and Data Protection Act. 2003 - 2009 |
| Impact | Submission of input into grant from Department of Constitutional Affairs which led to a booklet being provided on the Society for Intensive Care Website. |
| Description | Council of Intensive Care Society |
| Organisation | Intensive Care Society |
| Country | United Kingdom |
| Sector | Learned Society |
| PI Contribution | D.K Menon: Council of the Intensive Care Society - special respnsibility for the development of new legislation and regulations concerning Menal Capacity, Human Tissue Act, Clinical trials Directive and Data Protection Act. 2003 - 2009 |
| Impact | Submission of input into grant from Department of Constitutional Affairs which led to a booklet being provided on the Society for Intensive Care Website. |
| Description | Development and application of microfluidics |
| Organisation | Advion BioSciences |
| Country | United States |
| Sector | Private |
| PI Contribution | Development and application of microfuidics methods in the preparation of PET radiopharmaceuticals |
| Impact | tba |
| Start Year | 2008 |
| Description | Development of novel fluorination method |
| Organisation | Newcastle University |
| Department | School of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of novel fluorination method using iodonium compounds |
| Impact | tba |
| Start Year | 2009 |
| Description | ERASMUS Exchange Programme |
| Organisation | University of Groningen |
| Department | Department of Biomedical Engineering |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We provided human resources and research infrastructure for MSc students |
| Collaborator Contribution | MSc students |
| Impact | Publications |
| Start Year | 2011 |
| Description | ERASMUS Exchange Programme |
| Organisation | University of Lisbon |
| Department | Institute of Biophysics and Biomedical Engineering |
| Country | Portugal |
| Sector | Academic/University |
| PI Contribution | We provided human resources and research infrastructure for MSc students |
| Collaborator Contribution | MSc students |
| Impact | Publications |
| Start Year | 2011 |
| Description | Engineering - finite element analysis of decompressive craniectomy |
| Organisation | University of Cambridge |
| Department | Department of Engineering |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Increasing the understanding of the clinical consequences of brain deformation after craniectomy |
| Collaborator Contribution | Finite element analysis of decompressive craniectomy |
| Impact | Publications |
| Start Year | 2010 |
| Description | European Brain Injury Consortium |
| Organisation | Antwerp University Hospital |
| Country | Belgium |
| Sector | Hospitals |
| PI Contribution | European Brain Injury Consortium: Professor of Anaesthesia is now Co-Chair of the European Brain Injury Consortium, which has successfully lobbied the Directorate General (Health) of the European Commission to generate a call for research in TBI. |
| Impact | The EU funding has now been agreed, and the Framework7 program will be issuing a € 30 million call in 2012. |
| Start Year | 2011 |
| Description | ICNARC and NCCnet |
| Organisation | Queen's Medical Centre |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | ICNARC and NCCnet: Professor of Anaesthesia serves on the Management Board of the UK Intensive Care National Audit and Research Centre (ICNARC), and is Project Lead for NCCNet (http://www.nccnet.org.uk) - a research collaborative of UK neurocritical care units. |
| Impact | A collaboration that included ICNARC and NCCNet was recently awarded a £595,000 grant from the HTA. |
| Start Year | 2011 |
| Description | International Fellows |
| Organisation | University of Melbourne |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Steiner (Basal), Abate (Milan), Owler (Sydney), Zegan (Calgary), Gallagher (Calgary), Lewis (Melbourne) University of Melbeurne (Phil Lewis), Eric Schmidt (Toulouse), Jager (Leipzig), Momjian (Geneva), Lavinio (Brescia), Petrella (Rome), Balestreri (Pavia), Soehle (Bonn). |
| Impact | See publication listing |
| Start Year | 2006 |
| Description | International Fellows |
| Organisation | University of Melbourne |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Steiner (Basal), Abate (Milan), Owler (Sydney), Zegan (Calgary), Gallagher (Calgary), Lewis (Melbourne) University of Melbeurne (Phil Lewis), Eric Schmidt (Toulouse), Jager (Leipzig), Momjian (Geneva), Lavinio (Brescia), Petrella (Rome), Balestreri (Pavia), Soehle (Bonn). |
| Impact | See publications listing |
| Start Year | 2006 |
| Description | International Multicentre Randomised Trial |
| Organisation | European Brain Injury Consortium (EBIC) |
| Country | European Union (EU) |
| Sector | Charity/Non Profit |
| PI Contribution | Study set-up, patient recruitment and data collection |
| Collaborator Contribution | Patient recruitment |
| Impact | Recruitment of 280 patients from 43 centres in 17 countries |
| Description | International Multicentre Randomised Trial |
| Organisation | International Neurotrauma Society (INTS) |
| Country | Hungary |
| Sector | Charity/Non Profit |
| PI Contribution | Study set-up, patient recruitment and data collection |
| Collaborator Contribution | Patient recruitment |
| Impact | Recruitment of 280 patients from 43 centres in 17 countries |
| Description | International Multicentre Randomised Trial |
| Organisation | Society of British Neurological Surgeons |
| Country | United Kingdom |
| Sector | Learned Society |
| PI Contribution | Study set-up, patient recruitment and data collection |
| Collaborator Contribution | Patient recruitment |
| Impact | Recruitment of 280 patients from 43 centres in 17 countries |
| Description | MR Elastography |
| Organisation | Charité - University of Medicine Berlin |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We implemented and tested MRE equipment and methods on a 3T system. Developed an add-on for the image acquisition that allows automatic in-line analysis. |
| Collaborator Contribution | Delivered the concept for equipment and method and offered expertise in the clinical use of the methods |
| Impact | Constant improve of image acquisition and analysis methods. |
| Start Year | 2009 |
| Description | MR Elastography |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We implemented and tested MRE equipment and methods on a 3T system. Developed an add-on for the image acquisition that allows automatic in-line analysis. |
| Collaborator Contribution | Delivered the concept for equipment and method and offered expertise in the clinical use of the methods |
| Impact | Constant improve of image acquisition and analysis methods. |
| Start Year | 2009 |
| Description | Mitochondrial PET Probes |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Mitochondrial Biology Unit |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Radiosynthesis and biological evaluation of the PET radioligands |
| Collaborator Contribution | Novel PET probes. Synthesis and biological evaluation of novel chemical entities. |
| Impact | PMID: 20621583 |
| Start Year | 2008 |
| Description | NIHR HTC for Brain Injury |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Professor J D Pickard: Director of new HTC for Brain Injury, in CUHNHSFT. |
| Collaborator Contribution | NIHR is providing funding through the invention for the Innovation funding programme, in partnership with the Technology STrategy Board, the Engineering and Physical Sciences Research Council and the Medical Research Council. |
| Impact | HTC - Brain Injury covers several theme areas around brain injury of acquired and developmental origin across the acute care pathway: acute care including bedside monitoring, imaging, stem cells, genomic profiling and biomarkers. |
| Start Year | 2013 |
| Description | NINDS Common Data Elements in TBI |
| Organisation | National Institutes of Health (NIH) |
| Country | United States |
| Sector | Public |
| PI Contribution | NINDS Common Data Elements in TBI: Professor of Anaesthesia was part of an international and interagency working group sponsored by the NIH, NINDS and US Dept of Defense, which developed new approaches to clinical research in traumatic brain injury, and produced Common data Elements (CDE) for such research. |
| Impact | This process resulted in guidelines which underpins all TBI research, and the Professor of Anaesthesia is lead author on the first international consensus definition of traumatic brain injury. (see: http://www.commondataelements.ninds.nih.gov/TBI.aspx) |
| Start Year | 2011 |
| Description | Non-invasive assessment of intracranial pressure |
| Organisation | Albert Ludwigs University of Freiburg |
| Country | Germany |
| Sector | Hospitals |
| PI Contribution | Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang). |
| Impact | See publications listing |
| Start Year | 2006 |
| Description | Non-invasive assessment of intracranial pressure |
| Organisation | Albert Ludwigs University of Freiburg |
| Country | Germany |
| Sector | Hospitals |
| PI Contribution | Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang). |
| Impact | see publication listing |
| Start Year | 2006 |
| Description | Non-invasive assessment of intracranial pressure |
| Organisation | Chemnitz Academic Teaching Hospital |
| Department | Department of Neurology |
| Country | Germany |
| Sector | Hospitals |
| PI Contribution | Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang). |
| Impact | See publications listing |
| Start Year | 2006 |
| Description | Non-invasive assessment of intracranial pressure |
| Organisation | Chemnitz Academic Teaching Hospital |
| Department | Department of Neurology |
| Country | Germany |
| Sector | Hospitals |
| PI Contribution | Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang). |
| Impact | see publication listing |
| Start Year | 2006 |
| Description | Non-invasive assessment of intracranial pressure |
| Organisation | University of Kiel |
| Department | Department of Neurosurgery |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang). |
| Impact | see publication listing |
| Start Year | 2006 |
| Description | Non-invasive assessment of intracranial pressure |
| Organisation | University of Kiel |
| Department | Department of Neurosurgery |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang). |
| Impact | See publications listing |
| Start Year | 2006 |
| Description | Non-invasive assessment of intracranial pressure |
| Organisation | University of Memphis |
| Department | Medical Engineering Memphis |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang). |
| Impact | See publications listing |
| Start Year | 2006 |
| Description | Non-invasive assessment of intracranial pressure |
| Organisation | University of Memphis |
| Department | Medical Engineering Memphis |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Marek Czosnyka: Non-invasive assessment of intracranial pressure (Dept of Neurology, University of Chemnitz, Germany. Dr Berhard Schmidt); Novel forms of assessment of autoregulation using TCD (Dept of Neurology, University of Freiburg, Germany. Dr Matthias Reinhard); Modelling of crebrovascular pressure-reactivity(Department of Meidcal Engineering, (University of Memphis, USA, Prof M. Daly); Nonlinear properties of CBF regulation (Department of Neurosurgery, UCLA, USA, Dr Hu X). Haemodynamic response to increase in arterial blood pressure after TBI (Department of Neurosurgery, University of Kiel, Germany, Dr. E. Lang). |
| Impact | see publication listing |
| Start Year | 2006 |
| Description | Novel Copper-64 |
| Organisation | University of Bath |
| Department | Department of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Novel Copper-65 molecular imaging probes |
| Impact | tba |
| Start Year | 2008 |
| Description | Novel PET probes |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Clinical Sciences Centre (CSC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of novel PET probes of mitochondirial dysfunction |
| Impact | tba |
| Start Year | 2009 |
| Description | Novel PET probes |
| Organisation | University of Otago |
| Country | New Zealand |
| Sector | Academic/University |
| PI Contribution | Development of novel PET probes of mitochondirial dysfunction |
| Impact | tba |
| Start Year | 2009 |
| Description | Novel copper-64 |
| Organisation | University of Oxford |
| Department | Department of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of Copper-64 hypoxia markers |
| Impact | tba |
| Start Year | 2007 |
| Description | PET in stroke research |
| Organisation | University of Cambridge |
| Department | School of Clinical Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Application of PET in Stroke Research with Prof Jean-Claude Baron of Neurology/Stroke |
| Impact | see publications listing |
| Description | Post traumatic pituitary function working group |
| Organisation | Society of British Neurological Surgeons |
| Country | United Kingdom |
| Sector | Learned Society |
| PI Contribution | Led group. |
| Collaborator Contribution | Production of guidance. |
| Impact | In submission |
| Start Year | 2015 |
| Description | Siemens MRI |
| Organisation | Siemens Healthcare |
| Department | Siemens Medical Solutions |
| Country | Germany |
| Sector | Private |
| PI Contribution | Development of pulse sequences for use on Siemens MRI systems |
| Collaborator Contribution | Provision of the software development environment. Access to collaboration manager. |
| Impact | Improved pulse sequences for diffusion modelling and real-time fMRI |
| Start Year | 2006 |
| Description | Siemens Molecular Imaging |
| Organisation | Siemens Healthcare |
| Department | Siemens Medical Solutions |
| Country | Germany |
| Sector | Private |
| PI Contribution | Research collaboration in the development of PET probes for neurodegeneration. |
| Impact | tba |
| Start Year | 2009 |
| Title | Cranial access device |
| Description | MRI compatible device to transmit monitoring probes into the brain. |
| IP Reference | 9822006.4 |
| Protection | Patent granted |
| Year Protection Granted | |
| Licensed | Yes |
| Impact | Use in clinical practice |
| Title | ICM+ |
| Description | Software to collect data from multimodlaity bedside monitors in intensive care for subsequent analysis in real time. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | |
| Licensed | Yes |
| Impact | Basis for multinational research collaboration between worldcalss neurointensive care units. |
| Title | ICM+ software |
| Description | Software that allows the collection of data from multimodlaity bedside monitors in neurointensive care and subsequent analysis in real time. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | |
| Licensed | Yes |
| Impact | ICM+ is the basis of a multinational collaboration of worldclass neurointensive care units. |
| Title | 18F labelled endothelin and urotensin-II |
| Description | Automated synthesis of the generic peptide labelling agent N-succinimidyl 4-[(18)F]fluorobenzoate for synthesis of 18F labelled peptides for clinical use and application to (18)F-label to vasoactive transmitters endothelin and urotensin-II as ligands for positron emission tomography. |
| Type | Diagnostic Tool - Imaging |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2007 |
| Development Status | On hold |
| Impact | Publication of method has been adopted by others for synthesis of peptides for clinical use. |
| Title | ICM+ Sofware |
| Description | ICM+ software [www.neurosurg.cam.ac.uk/icmplus]. ICM+ captures the enormous quantities of physiological data from each patient in an neurointensive care environment form which information about cerebral auto regulation, cerebral compensatory reserve, oxygenation, metabolite production and function can be obtained. Minute to minute decisions about appropriate management can be made based on detection of changing cerebrovacular haemodynaamics. The same software has a major role in tyne management of hydrocephalus and other csf disorders. |
| Type | Support Tool - For Medical Intervention |
| Year Development Stage Completed | 2016 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | ICM+ (http://www.neurosurg.cam.ac.uk/icmplus), which is by now used in many clinical centres worldwide, attempts to bridge the gap between laboratory and clinical application. It collects data from bedside monitors, calculates in real time 'secondary' parameters defined using highly configurable signal processing formulae and produces continuously updated charts. This way complex information coming off the bedside monitors can be summarized in a concise fashion and presented to medical staff in a simple way that alerts them to the development of various pathological processes. ICM+ software licensed by University of Cambridge Enterprise Ltd. [www.neurosurg.cam.ac.uk/icmplus Novel methods of measurement developed by Marek Czosnyka, Peter Hutchinson, David Menon and John Pickard have provided new insights into the pathophysiology of brain injury, led to commercial applications, and influenced patient care in terms of improved outcome for clinical trials. Multimodality brain monitoring of intracranial pressure (ICP), brain oxygen and microdialysis; PET/MRI imaging of critically ill patients; and computerised CSF infusion tests for shunt function in hydrocephalus have each impacted on the clinical practice and the ability to evaluate novel treatments and interventions in brain injury. This work has led directly to the establishment of a National Institute for Health Research (NIHR) Health Technology Cooperative for Brain Injury. Underpinning research In 1991 a research group was established across Departments in the Cambridge University Clinical School to undertake research in traumatic brain injury (TBI) and abnormalities of CSF. The group was led jointly by Marek Czosnyka (Senior Research Associate, 1991; Professor of Brain Physics, from 2013), Peter Hutchinson (Reader in Neurosurgery, 2008-date; NIHR Professor from 2013), David Menon (University Lecturer, 1993; Professor of Anaesthesia, from 2000) and John Pickard (Professor of Neurosurgery, from 1991). Central to the impact has been the introduction of technologies derived from brain physics for real-time measurement of brain function in the context of acute injury. Technology that combines monitoring and imaging techniques has been licensed and has increased understanding of the pathophysiology of TBI and CSF disorders; defined optimal physiological parameters associated with best outcome in clinical trials; and altered the care of patients in the neurosciences intensive care setting nationally and internationally. The research encompasses four domains: Brain physics: By applying multimodal brain monitoring1 (introduced 1991) novel indices of cerebrovascular physiology have been defined including autoregulation with the following major findings: • TBI: (1) cerebrovascular pressure reactivity independently associates with outcome; (2) extremes of cerebral perfusion pressure (CPP) contribute to worse outcome; and (3) optimal CPP is a valid therapeutic target (2012)2 • CSF: (1) non-invasive ICP can be estimated from cerebral blood flow velocity and arterial pressure (2000); (2) normal pressure hydrocephalus results from a dysfunction of CSF dynamics, white matter softening and dysautoregulation with aging (2008); and (3) idiopathic intracranial hypertension can be treated with venous stenting (2002)3 |
| URL | http://www.neurosurg.cam.ac.uk/icm+home |
| Title | ICMplus |
| Description | ICM+ software [www.neurosurg.cam.ac.uk/icmplus]. ICM+ captures the enormous quantities of physiological data from each patient in an neurointensive care environment form which information about cerebral auto regulation, cerebral compensatory reserve, oxygenation, metabolite production and function can be obtained. Minute to minute decisions about appropriate management can be made based on detection of changing cerebrovacular haemodynaamics. The same software has a major role in tyne management of hydrocephalus and other csf disorders. |
| Type Of Technology | Software |
| Year Produced | 2006 |
| Impact | ICM+ (http://www.neurosurg.cam.ac.uk/icmplus), which is by now used in many clinical centres worldwide, attempts to bridge the gap between laboratory and clinical application. It collects data from bedside monitors, calculates in real time 'secondary' parameters defined using highly configurable signal processing formulae and produces continuously updated charts. This way complex information coming off the bedside monitors can be summarized in a concise fashion and presented to medical staff in a simple way that alerts them to the development of various pathological processes. ICM+ software licensed by University of Cambridge Enterprise Ltd. [www.neurosurg.cam.ac.uk/icmplus |
| URL | http://www.neurosurg.cam.ac.uk/icm+home |
| Title | ICMplus |
| Description | ICU monitoring software. Developed by Marek Czosnyka and Peter Smielewski. |
| Type Of Technology | Software |
| Impact | Take up internationally |
| Company Name | ICMplus - Cambridge Enterprise. Led by Marek Czosnyka and Peter Smielewski. |
| Description | Medical software, |
| Impact | Improvement of monitoring and data capture in Intensive Care. |
| Company Name | Technicam and Medicam |
| Description | www.technicam.co.uk Technicam Limited, a British company, was established in 2000 by a group of neurosurgeons and Centrax Limited of Newton Abbot, a precision engineering company. The aim of the company is the development of innovative advances in the field of surgical devices. All Technicam products are patent protected and CE marked. The Technicam Cranial Access Device has received an award as a Millenium Product for innovatio |
| Impact | The indications for skull burr-holes include insertion of intra-cranial bolts, insertion of exterior ventricular drains(ventriculostomies) , insertion of ventricular catheters for shunts , drainage of chronic subdural haematomas and access for brain biopsies. Burr-holes have been traditionally performed either by using air-powered drills or by hand using a brace, perforator and spherical burr. Recently the demand for cranial access via burr-holes has increased due to the application of monitoring probes, (intra-cranial) pressure transducers, oxygen and multi-parameter sensors and micro-dialysis catheters, and the increasing use of external ventricular drains in patients with head injury and subarachnoid haemorrhage. Traditionally, burr-holes have been performed in the operating theatre. By undertaking them on the intensive care unit, however, the complications of transferring the patient to the operating theatre can be avoided. Technicam have therefore developed a new cranial access system designed to simplify burr-holes, and facilitate the insertion of monitoring probes and external ventricular drains for use in the intensive care unit or the operating theatre - the Technicam Cranial Access System. |
| Website | http://www.technicam.co.uk |
| Company Name | Technicam and Medicam |
| Description | www.technicam.co.uk Technicam Limited, a British company, was established in 2000 by a group of neurosurgeons and Centrax Limited of Newton Abbot, a precision engineering company. The aim of the company is the development of innovative advances in the field of surgical devices. All Technicam products are patent protected and CE marked. The Technicam Cranial Access Device has received an award as a Millenium Product for innovation The indications for skull burr-holes include insertion of intra-cranial bolts, insertion of exterior ventricular drains(ventriculostomies) , insertion of ventricular catheters for shunts , drainage of chronic subdural haematomas and access for brain biopsies. Burr-holes have been traditionally performed either by using air-powered drills or by hand using a brace, perforator and spherical burr. Recently the demand for cranial access via burr-holes has increased due to the application of monitoring probes, (intra-cranial) pressure transducers, oxygen and multi-parameter sensors and micro-dialysis catheters, and the increasing use of external ventricular drains in patients with head injury and subarachnoid haemorrhage. Traditionally, burr-holes have been performed in the operating theatre. By undertaking them on the intensive care unit, however, the complications of transferring the patient to the operating theatre can be avoided. |
| Impact | Technicam have therefore developed a new cranial access system designed to simplify burr-holes, and facilitate the insertion of monitoring probes and external ventricular drains for use in the intensive care unit or the operating theatre - the Technicam Cranial Access System. |
| Website | http://www.technicam.co.uk |
| Description | Between Life and Death |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The NCCU was the context for a recent BBC program on decision making in severe brain injury: "Between Life and Death" aired on BBCi on the 13th of July 2010. This program, and the accompanying blog by Professor of Anaesthesia have resulted in enormous public and media interest and discussion (see: http://www.bbc.co.uk/blogs/tv/2010/07/between-life-and-death-why-med.shtml#comments and http://www.bbc.co.uk/programmes/b00t3szs). An email to Professor of Anaesthesia from the Executive Producer of the program quotes the Head of BBC1 stating the film to be "one of the best uses of public service broadcasting" she has been involved with. Extremely well received.This year the BBC documentary "Between Life and Death", filmed in the Neurocritical Care Unit about three patients' journeys post neurotrauma (see: http://www.bbc.co.uk/programmes/b00t3szs), generated a BBC blog run by Professor of Anaesthesia (http://www.bbc.co.uk/blogs/tv/2010/07/between-life-and-death-why-med.shtml), and won a BAFTA television award (http://www.youtube.com/watch?v=8seN2xUwPxA) and a Royal Television Society Award. |
| Year(s) Of Engagement Activity | 2010,2011 |
| URL | http://www.bbc.co.uk/blogs/tv/2010/07/between-life-and-death-why-med.shtml#comments |
| Description | Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Over 30,000 members of the public attend. Open to families and school groups etc. B.Sahakian - patron 2007 Very successful event as it combines fun and education. The support of the MRC is emphasised ast every appropriate opportunity. |
| Year(s) Of Engagement Activity | 2007,2008,2009,2010 |
| Description | Headway support groups |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | TBI patients attended lectures by DKM, JDP and PJAH. Mind your head i a crowd sourcing pilot that involvs the general public, business angels and the new University Technical College Headway invited patient groups to the lectures the outcomes of Mind your head is under review |
| Year(s) Of Engagement Activity | 2006,2007,2008,2010,2014 |
| Description | Headway support groups |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | TBI patients attended lectures by DKM, JDP and PJAH Headway invited patient groups to the lectures. |
| Year(s) Of Engagement Activity | 2006,2007,2008 |
| Description | Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Professor of Anaesthesia lecture to Royal Grammar School Guildford and Queens College, Cambridge - at the request of patient groups, including Headway. HIgh interest from students |
| Year(s) Of Engagement Activity | 2008,2009,2010 |
| Description | National Science Week |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 25 students from Cambridge school attended open- day talks on MRI and PET. School reported high interest. |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | National debates |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | DKM contributed substantially to the debate on the Mental Capacity Act, the EU Clinical trials Directive, the Data Protection Act and the Human Tissue Act. JDP has contributed to the Royal College Working Parties on Brain Death, Vegetative State and Mental Incapacity as well as providing advice to the Official Solicitor. All amendments, suggested at the committee stage have been incorporated into the respective acts and regulations, ensuring that acute brain injury research can continue. |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009 |
| Description | New Frontiers in Science Exhibition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | national exhibition Press release for WBIC |
| Year(s) Of Engagement Activity | 2006 |
| Description | Open Days |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Cambridgeshire schools attended one day presentations of MRI and PET by the WBIC N/A |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | Physics at Work |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | over 200 students from Cambridge area schools participate high participation from high schools |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | Physics at Work programme |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | More than 200 pupils from Cambridge high schools attend. n/a |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | Physics at Work programme |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | More than 200 pupils from Cambridge high schools attend. n/a |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | Radio interview Today programme 28.11.2013 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | TODAY programme has a UK wide auience Times also reported the launch |
| Year(s) Of Engagement Activity | 2013 |
| Description | Regional conference lectures |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation at event showcasing the CenterTBI study in Sheffield sponsored by Irwin Mitchell and attended by health professionals, local support charities and the public - 19th June 2015 Oral presentation to the Eastern Region Brain Injury Forum concerning the CenterTBI study sponsored by Slater & Gordon In Cambridge to raise public & professional awareness of acquired brain injury and improve standards of care for patients - 21st October 2015 |
| Year(s) Of Engagement Activity | 2015 |
| Description | SCIENCE publication |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Our breakthrough publication (in Science) in collaboration with the MRC Cognition and Brain Sciences Unit demonstrated that it was possible to detect conscious awareness in patients suffering from persistent vegetative state (PVS) using neuro-imaging techniques (fMRI). This publication attracted an astonishing level of international attention from the news media and was widely discussed on TV, radio, in print and on line. Articles describing the work appeared in over 350 newspapers around the world and on multiple TV and radio reports. According to the MRC Press Office, this was the largest media response ever recorded to an MRC-funded scientific achievement. Editorial commentaries on the work were published in several scientific journals, including Science and Nature. |
| Year(s) Of Engagement Activity | 2006 |
| Description | SCIENCE publication |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Our breakthrough publication (in Science) in collaboration with the MRC Cognition and Brain Sciences Unit demonstrated that it was possible to detect conscious awareness in patients suffering from persistent vegetative state (PVS) using neuro-imaging techniques (fMRI). This publication attracted an astonishing level of international attention from the news media and was widely discussed on TV, radio, in print and on line. Articles describing the work appeared in over 350 newspapers around the world and on multiple TV and radio reports. According to the MRC Press Office, this was the largest media response ever recorded to an MRC-funded scientific achievement Editorial commentaries on the work were published in several scientific journals, including Science and Nature |
| Year(s) Of Engagement Activity | 2006 |
| Description | Society of British Neurological Surgeons |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | JD Pickard Presicent and National Selection Working Party; Formerly member of Council, Proceedings Editor, WFNS/EANS representative, formerly Chairman, Intercollegiate Board in Surgical Neurology, member Joint Committee of Intercollegiate Examinations, Surgical Advisory Committee for Neurosurgery (Royal College of Surgeons Representative), Higher Surgical Training Committee (Royal College of Surgeons of England). as above |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009 |
| Description | Specialised Print media |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Contributed articles in the popular press and children's science magazines as well as more specialised print media including MRC News, television, raido and press interviews - often prompted by scientific publications, released by the University and Addenbrookes Press Offices and University website. Schools and media ask to visit N/A |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | Specialised Print media |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Contributed articles in the popular press and children's science magazines as well as more specialised print media including MRC News, television, raido and press interviews - often prompted by scientific publications, released by the University and Addenbrookes Press Offices and University website. Schools and media ask to visit. |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | TV Documentary |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Poster Presentation |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Panorama Special programme. This programme was extremely well received and broadcast to many countries around the world. |
| Year(s) Of Engagement Activity | 2012 |
| URL | http://www.bbc.co.uk/news/health-20268044 |
| Description | TV News |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Pilot studies on Down's syndrome with PIB on Channel 4 news http://www.channel4.com/news/more-people_with_downs_syndrome-developing_dementia. na |
| Year(s) Of Engagement Activity | 2011 |
| Description | University Alumni annual visit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | average of 20 - 40 alumni visit annually. Professor Pickard's 2013 lecture was highly rated and attracted some 200 delegates Always well received. |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |