Host determinants of malaria immunity and pathogenesis

Lead Research Organisation: University of Oxford
Department Name: Wellcome Trust Centre for Human Genetics

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Description PAMGEM 
Organisation Addis Ababa University
Country Ethiopia 
Sector Academic/University 
PI Contribution The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. Recently funded by the H3 Africa Initiative, PAMGEM is a natural evolution of the Centre for Genomics and Global Health capacity building activities. Several of the lead applicants have a longstanding involvement in CGGH and have received training, mentorship and practical support through it the bursary scheme supported by the MRC Centenary award, data clinics and advanced training workshops. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through CGGH developed web interfaces.
Collaborator Contribution PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa.
Impact The partnership has resulted in funding of $3m for PAMGEM.
Start Year 2017
 
Description PAMGEM 
Organisation Kenyan Institute for Medical Research (KEMRI)
Country Kenya 
Sector Public 
PI Contribution The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. Recently funded by the H3 Africa Initiative, PAMGEM is a natural evolution of the Centre for Genomics and Global Health capacity building activities. Several of the lead applicants have a longstanding involvement in CGGH and have received training, mentorship and practical support through it the bursary scheme supported by the MRC Centenary award, data clinics and advanced training workshops. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through CGGH developed web interfaces.
Collaborator Contribution PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa.
Impact The partnership has resulted in funding of $3m for PAMGEM.
Start Year 2017
 
Description PAMGEM 
Organisation Medical Research Council (MRC)
Department MRC Unit, The Gambia
Country Gambia 
Sector Public 
PI Contribution The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. Recently funded by the H3 Africa Initiative, PAMGEM is a natural evolution of the Centre for Genomics and Global Health capacity building activities. Several of the lead applicants have a longstanding involvement in CGGH and have received training, mentorship and practical support through it the bursary scheme supported by the MRC Centenary award, data clinics and advanced training workshops. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through CGGH developed web interfaces.
Collaborator Contribution PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa.
Impact The partnership has resulted in funding of $3m for PAMGEM.
Start Year 2017
 
Description PAMGEM 
Organisation Pasteur Institute of Madagascar
Country Madagascar 
Sector Academic/University 
PI Contribution The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. Recently funded by the H3 Africa Initiative, PAMGEM is a natural evolution of the Centre for Genomics and Global Health capacity building activities. Several of the lead applicants have a longstanding involvement in CGGH and have received training, mentorship and practical support through it the bursary scheme supported by the MRC Centenary award, data clinics and advanced training workshops. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through CGGH developed web interfaces.
Collaborator Contribution PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa.
Impact The partnership has resulted in funding of $3m for PAMGEM.
Start Year 2017
 
Description PAMGEM 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. Recently funded by the H3 Africa Initiative, PAMGEM is a natural evolution of the Centre for Genomics and Global Health capacity building activities. Several of the lead applicants have a longstanding involvement in CGGH and have received training, mentorship and practical support through it the bursary scheme supported by the MRC Centenary award, data clinics and advanced training workshops. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through CGGH developed web interfaces.
Collaborator Contribution PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa.
Impact The partnership has resulted in funding of $3m for PAMGEM.
Start Year 2017
 
Description PAMGEM 
Organisation University of Bamako
Department Malaria Research and Training Centre (MRTC) Bamako
Country Mali 
Sector Academic/University 
PI Contribution The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. Recently funded by the H3 Africa Initiative, PAMGEM is a natural evolution of the Centre for Genomics and Global Health capacity building activities. Several of the lead applicants have a longstanding involvement in CGGH and have received training, mentorship and practical support through it the bursary scheme supported by the MRC Centenary award, data clinics and advanced training workshops. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through CGGH developed web interfaces.
Collaborator Contribution PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa.
Impact The partnership has resulted in funding of $3m for PAMGEM.
Start Year 2017
 
Description PAMGEM 
Organisation University of Buea
Country Cameroon 
Sector Academic/University 
PI Contribution The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. Recently funded by the H3 Africa Initiative, PAMGEM is a natural evolution of the Centre for Genomics and Global Health capacity building activities. Several of the lead applicants have a longstanding involvement in CGGH and have received training, mentorship and practical support through it the bursary scheme supported by the MRC Centenary award, data clinics and advanced training workshops. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through CGGH developed web interfaces.
Collaborator Contribution PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa.
Impact The partnership has resulted in funding of $3m for PAMGEM.
Start Year 2017