Mechanisms of expression of NMDA receptor-dependent LTP and LTD in the hippocampus

Lead Research Organisation: University of Bristol
Department Name: Anatomy

Abstract

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Publications

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Collett VJ (2004) Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells. in British journal of pharmacology

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Lauri SE (2005) Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus. in The Journal of neuroscience : the official journal of the Society for Neuroscience

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Massey PV (2004) Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. in The Journal of neuroscience : the official journal of the Society for Neuroscience

 
Description MRC Project Grant
Amount £1,866,640 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2008 
End 12/2012
 
Title Win LTP - software 
Description Software for the delivery of stimuli and e=analysis of electrophysiologigal data 
Type Of Material Technology assay or reagent 
Year Produced 2006 
Provided To Others? Yes  
Impact adding to the research ability of labs across the world 
 
Description DT Monaghan 
Organisation University of Nebraska–Lincoln
Department University of Nebraska Medical Centre
Country United States 
Sector Academic/University 
PI Contribution Initial synthesis of novel compounds that act as NMDA receptor allosteric modulators. Analysis of effects on plasticty in in vitro slice preparations.
Collaborator Contribution Initial pharmacological characterisation of allosteric modulators using Xenopus Oocyte preparations.
Impact Publications in relevant journals
Start Year 2012
 
Description Eli Lilly 
Organisation Eli Lilly & Company Ltd
Country United Kingdom 
Sector Private 
PI Contribution Screening of cloned receptors for KAR antagonists
Collaborator Contribution screening of cloned receptors
Impact New antagonists developed, eg UBP296
 
Description GSK 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Provision of transgenic animals
Collaborator Contribution provision of transgenic animals
Impact Publications
 
Description Novartis 
Organisation Novartis
Country Global 
Sector Private 
PI Contribution provision of antagonist
Collaborator Contribution provision of NR selective antagonist
Impact publications
 
Description Sari Lauri 
Organisation University of Helsinki
Country Finland 
Sector Academic/University 
PI Contribution produced principal experimental data for publications
Collaborator Contribution experimental data
Impact publications
 
Description YT Wang 
Organisation University of British Columbia
Country Canada 
Sector Academic/University 
PI Contribution Provision of experimental data
Collaborator Contribution Provision of experimental data
Impact publications
Start Year 2006
 
Title Win LTP software 
Description Software to deliver stimuli and to analyse electrophysiological recordings 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted
Licensed No
Impact Software is being used in laboratories across the world to further knowledge
 
Title WinLTP 
Description Software to perform electrophysiological experiments 
Type Of Technology Software 
Year Produced 2006 
Impact This software is currently in use in a range of laboratories throughout the world 
 
Description Brain Awareness Week/Science Alive 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Hands on activities in a local shopping centre where the general public could do activities and learn about the work we do.

Interest in our research
Year(s) Of Engagement Activity 2006
 
Description School visits - various 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact talks and activities about the brain and how memory works

Interst from school children
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description public talks - various 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talks to public audiences on aspects of our work

interst in our work
Year(s) Of Engagement Activity 2006,2007,2008,2014